#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78423	uniprotkb:P69332	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-16147206|uniprotkb:P09704|uniprotkb:P32952|uniprotkb:Q7M6H3	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:us28_hcmva(display_long)|uniprotkb:US28(gene name)|psi-mi:US28(display_short)|uniprotkb:HHRF3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Burg et al. (2015)	pubmed:25745166|doi:10.1126/science.aaa5026|imex:IM-24334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10360(hcmva)|taxid:10360("Human cytomegalovirus (strain AD169) (HHV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147228|imex:IM-24334-1|dip:DIP-198960E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	go:"GO:0004950"(chemokine receptor activity)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|go:"GO:0044864"(positive regulation by virus of host cell division)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4XT1|rcsb pdb:4XT3|dip:DIP-61489N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:Mow2xKD1VMaZtOo/EtPRdSeMJ1w10360	rigid:bk1j1EXdhpIkzxIXXxrCdE3WekE	false	sufficient binding region:25-101|fc-igg tag:c-c	sufficient binding region:11-310	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78423	uniprotkb:P69332	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-16147206|uniprotkb:P09704|uniprotkb:P32952|uniprotkb:Q7M6H3	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:us28_hcmva(display_long)|uniprotkb:US28(gene name)|psi-mi:US28(display_short)|uniprotkb:HHRF3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Burg et al. (2015)	pubmed:25745166|doi:10.1126/science.aaa5026|imex:IM-24334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10360(hcmva)|taxid:10360("Human cytomegalovirus (strain AD169) (HHV-5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147274|imex:IM-24334-3|dip:DIP-198960E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	go:"GO:0004950"(chemokine receptor activity)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|go:"GO:0044864"(positive regulation by virus of host cell division)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4XT1|rcsb pdb:4XT3|dip:DIP-61489N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:Mow2xKD1VMaZtOo/EtPRdSeMJ1w10360	rigid:bk1j1EXdhpIkzxIXXxrCdE3WekE	false	sufficient binding region:25-101	sufficient binding region:11-310	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78423	uniprotkb:P69332	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-16147206|uniprotkb:P09704|uniprotkb:P32952|uniprotkb:Q7M6H3	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:us28_hcmva(display_long)|uniprotkb:US28(gene name)|psi-mi:US28(display_short)|uniprotkb:HHRF3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Burg et al. (2015)	pubmed:25745166|doi:10.1126/science.aaa5026|imex:IM-24334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10360(hcmva)|taxid:10360("Human cytomegalovirus (strain AD169) (HHV-5)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147251|imex:IM-24334-2|dip:DIP-198960E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	go:"GO:0004950"(chemokine receptor activity)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|go:"GO:0044864"(positive regulation by virus of host cell division)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4XT1|rcsb pdb:4XT3|dip:DIP-61489N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:Mow2xKD1VMaZtOo/EtPRdSeMJ1w10360	rigid:bk1j1EXdhpIkzxIXXxrCdE3WekE	false	sufficient binding region:25-101	sufficient binding region:11-310	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78423	uniprotkb:P69332	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-16147206|uniprotkb:P09704|uniprotkb:P32952|uniprotkb:Q7M6H3	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:us28_hcmva(display_long)|uniprotkb:US28(gene name)|psi-mi:US28(display_short)|uniprotkb:HHRF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Burg et al. (2015)	pubmed:25745166|doi:10.1126/science.aaa5026|imex:IM-24334	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10360(hcmva)|taxid:10360("Human cytomegalovirus (strain AD169) (HHV-5)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147295|imex:IM-24334-4|dip:DIP-198960E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	go:"GO:0004950"(chemokine receptor activity)|go:"GO:0006935"(chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|go:"GO:0044864"(positive regulation by virus of host cell division)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4XT1|rcsb pdb:4XT3|dip:DIP-61489N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:Mow2xKD1VMaZtOo/EtPRdSeMJ1w10360	rigid:bk1j1EXdhpIkzxIXXxrCdE3WekE	false	sufficient binding region:25-101	sufficient binding region:11-310|flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)