#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13945996|imex:IM-25702-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Table 2|comment:B5701 allele|3d-resolution:2.3A|comment:The alanine substitution at residue 101 abolishes the only direct peptide interaction with KIR3DL1*001.|3d-r-factors:Rfree =0.257|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false sufficient binding region:25..25-308..308 mutation:101-101|sufficient binding region:94-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13945996|imex:IM-25702-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Table 2|comment:B5701 allele|3d-resolution:2.3A|comment:The alanine substitution at residue 101 abolishes the only direct peptide interaction with KIR3DL1*001.|3d-r-factors:Rfree =0.257|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false sufficient binding region:25..25-308..308 tag:n-n|sufficient binding region:22-320|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0114"(x-ray crystallography) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13945996|imex:IM-25702-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Table 2|comment:B5701 allele|3d-resolution:2.3A|comment:The alanine substitution at residue 101 abolishes the only direct peptide interaction with KIR3DL1*001.|3d-r-factors:Rfree =0.257|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false sufficient binding region:25..25-308..308 sufficient binding region:1-99 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946033|imex:IM-25702-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Table 2-2|comment:B5701 allele|3d-resolution:1.9A|3d-r-factors:Rfree =0.247|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:VC7kdxbCZDZwdnVqCfCsmDZk7HI false sufficient binding region:25..25-308..308 mutation:101-101|sufficient binding region:94-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0114"(x-ray crystallography) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946033|imex:IM-25702-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Table 2-2|comment:B5701 allele|3d-resolution:1.9A|3d-r-factors:Rfree =0.247|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:VC7kdxbCZDZwdnVqCfCsmDZk7HI false sufficient binding region:25..25-308..308 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:I4ENP2 uniprotkb:P04591 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-6163428 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946748|imex:IM-25702-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-2"|comment:B5701 allele;G9D Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:240-249|mutation disrupting interaction strength:242-242 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946748|imex:IM-25702-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-2"|comment:B5701 allele;G9D Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation disrupting interaction strength:184-184|mutation disrupting interaction strength:159-159|flag tag:n-n|mutation disrupting interaction strength:187-187|mutation increasing interaction strength:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946748|imex:IM-25702-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2C (D)-2"|comment:B5701 allele;G9D Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P04591 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-6163428 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946696|imex:IM-25702-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-3"|comment:B5701 allele;T3N Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:240-249|mutation disrupting interaction strength:238-238 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946696|imex:IM-25702-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-3"|comment:B5701 allele;T3N Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation disrupting interaction strength:184-184|mutation disrupting interaction strength:159-159|flag tag:n-n|mutation increasing interaction strength:187-187|mutation disrupting interaction strength:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946696|imex:IM-25702-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2C (D)-3"|comment:B5701 allele;T3N Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P43629 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946669|imex:IM-25702-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-2"|comment:A2402 allele;Y2F mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation decreasing interaction strength:184-184|mutation decreasing interaction strength:159-159|flag tag:n-n|mutation disrupting interaction strength:187-187|mutation decreasing interaction strength:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P04601 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946669|imex:IM-25702-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-2"|comment:A2402 allele;Y2F mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation decreasing interaction strength:135-135|sufficient binding region:134-141 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P61769-PRO_0000018779 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-13942645 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946669|imex:IM-25702-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV intact:EBI-714718(chain-parent) - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2A (B)-2"|comment:A2402 allele;Y2F mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P43629 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946642|imex:IM-25702-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-3"|comment:A2402 allele;W8A mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation decreasing interaction strength:184-184|mutation decreasing interaction strength:159-159|flag tag:n-n|mutation disrupting interaction strength:187-187|mutation increasing interaction strength:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P04601 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946642|imex:IM-25702-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-3"|comment:A2402 allele;W8A mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:141-141|sufficient binding region:134-141 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P61769-PRO_0000018779 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-13942645 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946642|imex:IM-25702-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV intact:EBI-714718(chain-parent) - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2A (B)-3"|comment:A2402 allele;W8A mutant NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P04591 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-6163428 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946775|imex:IM-25702-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-1"|comment:B5701 allele;WT Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:240-249 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946775|imex:IM-25702-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:"Figure 2C (D)-1"|comment:B5701 allele;WT Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:184-184|mutation with no effect:159-159|flag tag:n-n|mutation decreasing interaction strength:187-187|mutation increasing interaction strength:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946775|imex:IM-25702-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2C (D)-1"|comment:B5701 allele;WT Gag p24 fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:+kcbEC0YtAppmyhAErtzljaCzIc false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P43629 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946723|imex:IM-25702-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-1"|comment:A2402 allele;WT NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation decreasing interaction strength:184-184|mutation decreasing interaction strength:159-159|flag tag:n-n|mutation disrupting interaction strength:187-187|mutation with no effect:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P04601 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946723|imex:IM-25702-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. - figure legend:"Figure 2A (B)-1"|comment:A2402 allele;WT NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:134-141 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q95J06 uniprotkb:P61769-PRO_0000018779 intact:EBI-4289581|uniprotkb:Q29909|uniprotkb:Q95355|uniprotkb:Q29908|uniprotkb:Q29910|uniprotkb:P30449|uniprotkb:P30448 intact:EBI-13942645 psi-mi:1a24_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-24(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-9 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*24(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13946723|imex:IM-25702-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:P05534(see-also)|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:2BCK|rcsb pdb:3I6L|rcsb pdb:3NFN|rcsb pdb:3QZW|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|rcsb pdb:4WU5|rcsb pdb:4WU7|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|interpro:IPR036179|interpro:IPR037055|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0046977"(TAP binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|go:"GO:0042605"(peptide antigen binding)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|rcsb pdb:3WL9|rcsb pdb:3WLB|ensembl:ENSG00000224320|ensembl:ENSG00000229215|ensembl:ENSP00000404678|ensembl:ENSP00000406366|ensembl:ENST00000431930|ensembl:ENST00000443552|rcsb pdb:5XOV intact:EBI-714718(chain-parent) - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions. chain-seq-start:21|chain-seq-end:119 figure legend:"Figure 2A (B)-1"|comment:A2402 allele;WT NEF fragment|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/09 rogid:uFLABQPxYOVvi/ddEG9HslnbSnA9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:i+PICoBJpvXWT+SDbwFy8ZiMzwg false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947144|imex:IM-25702-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation increasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation increasing interaction strength:101-101|sufficient binding region:94-102|mutation with no effect:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947144|imex:IM-25702-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947144|imex:IM-25702-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5A-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947211|imex:IM-25702-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation decreasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation with no effect:101-101|sufficient binding region:94-102|mutation decreasing interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947211|imex:IM-25702-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947211|imex:IM-25702-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 3-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947399|imex:IM-25702-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-3|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation disrupting interaction strength:101-101|mutation increasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation increasing interaction strength:101-101|sufficient binding region:94-102|mutation disrupting interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947399|imex:IM-25702-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-3|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947399|imex:IM-25702-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 3-3|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947473|imex:IM-25702-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-4|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation increasing interaction strength:101-101|mutation increasing interaction strength:101-101|mutation with no effect:101-101|mutation disrupting interaction strength:101-101|mutation increasing interaction strength:101-101|sufficient binding region:94-102|mutation disrupting interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947473|imex:IM-25702-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-4|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947473|imex:IM-25702-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 3-4|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947506|imex:IM-25702-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation decreasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation with no effect:101-101|sufficient binding region:94-102|mutation decreasing interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947506|imex:IM-25702-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 3-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947506|imex:IM-25702-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 3-1|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947871|imex:IM-25702-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-2|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation decreasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation with no effect:101-101|sufficient binding region:94-102|mutation decreasing interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947871|imex:IM-25702-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-2|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|mutation:159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13947871|imex:IM-25702-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5A-2|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948172|imex:IM-25702-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-3|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation with no effect:101-101|mutation decreasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation with no effect:101-101|sufficient binding region:94-102|mutation decreasing interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948172|imex:IM-25702-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-3|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|mutation:184-184 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948172|imex:IM-25702-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5A-3|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948207|imex:IM-25702-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-4|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation disrupting interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation decreasing interaction strength:101-101|sufficient binding region:94-102|mutation disrupting interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948207|imex:IM-25702-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-4|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|mutation:220-220 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948207|imex:IM-25702-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5A-4|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948239|imex:IM-25702-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-5|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation increasing interaction strength:101-101|mutation increasing interaction strength:101-101|mutation decreasing interaction strength:101-101|mutation disrupting interaction strength:101-101|mutation increasing interaction strength:101-101|sufficient binding region:94-102|mutation decreasing interaction strength:101-101 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P43629 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948239|imex:IM-25702-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5A-5|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|mutation:187-187 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948239|imex:IM-25702-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5A-5|comment:B5701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/03/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:Lw9BHpGZP5P/Ow96iukM/ZrJQBI false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P01834 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-1054530|uniprotkb:A0A075B6H6|uniprotkb:A0A087X130 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:igkc_human(display_long)|uniprotkb:IGKC(gene name)|psi-mi:IGKC(display_short)|uniprotkb:Ig kappa chain C region(gene name synonym)|uniprotkb:Ig kappa chain C region AG(gene name synonym)|uniprotkb:Ig kappa chain C region CUM(gene name synonym)|uniprotkb:Ig kappa chain C region EU(gene name synonym)|uniprotkb:Ig kappa chain C region OU(gene name synonym)|uniprotkb:Ig kappa chain C region ROY(gene name synonym)|uniprotkb:Ig kappa chain C region TI(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948302|imex:IM-25702-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T rcsb pdb:2NY7|rcsb pdb:1N0X|rcsb pdb:4NM4|rcsb pdb:4NM8|rcsb pdb:6N2X|rcsb pdb:6N32|rcsb pdb:6N35|rcsb pdb:4XMP|rcsb pdb:4XNY|rcsb pdb:4XNZ|rcsb pdb:4XXD|rcsb pdb:4YDV|rcsb pdb:4D3C|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5ESV|rcsb pdb:5ESZ|reactome:R-HSA-5690714|rcsb pdb:6OGE|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1A4J|rcsb pdb:1A4K|rcsb pdb:1D5B|rcsb pdb:1D5I|rcsb pdb:1D6V|rcsb pdb:1HEZ|rcsb pdb:1HKL|rcsb pdb:1I7Z|rcsb pdb:1MIM|rcsb pdb:1UCB|rcsb pdb:2O5X|rcsb pdb:2O5Y|rcsb pdb:2O5Z|rcsb pdb:2QQK|rcsb pdb:2QQL|rcsb pdb:2QQN|rcsb pdb:2QSC|rcsb pdb:2R56|rcsb pdb:2VXQ|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BDY|rcsb pdb:3BE1|rcsb pdb:3BKY|rcsb pdb:3BN9|rcsb pdb:3BQU|rcsb pdb:3C08|rcsb pdb:3C09|rcsb pdb:3CFJ|rcsb pdb:3CFK|rcsb pdb:3CSY|rcsb pdb:3D0L|rcsb pdb:3D85|rcsb pdb:3DVG|rcsb pdb:3DVN|rcsb pdb:3EYF|rcsb pdb:3EYO|rcsb pdb:3EYQ|rcsb pdb:3U7W|rcsb pdb:3U7Y|rcsb pdb:3VH8|rcsb pdb:5B39|rcsb pdb:5B38|reactome:R-HSA-202733|rcsb pdb:3U0W|rcsb pdb:1DFB|rcsb pdb:3WUW|rcsb pdb:1HZH|rcsb pdb:3O11|rcsb pdb:3QCT|rcsb pdb:3QCU|rcsb pdb:3QCV|rcsb pdb:4D9R|rcsb pdb:4HIX|go:"GO:0001895"(retina homeostasis)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:1CLY|rcsb pdb:1GAF|rcsb pdb:2RFX|rcsb pdb:3IU3|rcsb pdb:3RU8|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-983695|rcsb pdb:6AU5|rcsb pdb:6AXP|rcsb pdb:6AYN|rcsb pdb:6AZK|rcsb pdb:6AZL|reactome:R-HSA-977606|rcsb pdb:7CZY|rcsb pdb:7CZZ|rcsb pdb:5VEB|rcsb pdb:5VIY|interpro:IPR036179|rcsb pdb:6B9Y|rcsb pdb:6B9Z|rcsb pdb:6BAE|rcsb pdb:6BAH|rcsb pdb:6DCV|rcsb pdb:6DCW|rcsb pdb:6OKP|reactome:R-HSA-9664323|reactome:R-HSA-9664422 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5D|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:TlqDc4NqqQkVNViyRU/dy+tYX2c9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 mutation increasing interaction strength:101-101|mutation increasing interaction strength:101-101|mutation increasing interaction strength:101-101|sufficient binding region:94-102 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948302|imex:IM-25702-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 5D|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948302|imex:IM-25702-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 5D|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:18hDL3UjdVtfHkhqw3Sk9E2yIUU false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948339|imex:IM-25702-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 6B-1|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:L/PMGJHAdcm+Aozejn/y0O4+SyM false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P24741 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13948365 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:nef_hv1u4(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11703(isolate U455)|taxid:11703(Human immunodeficiency virus type 1 group M subtype A) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948339|imex:IM-25702-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR027480|interpro:IPR027481|interpro:IPR001558(HIV negative factor Nef) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 6B-1|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:Vq0a26/GFgeulQ6xajGFtk3JJjI11703 rigid:L/PMGJHAdcm+Aozejn/y0O4+SyM false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:82-90 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948339|imex:IM-25702-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 6B-1|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:L/PMGJHAdcm+Aozejn/y0O4+SyM false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:Q14943 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-15316524|ensembl:ENSP00000481772|uniprotkb:A0A0G2JNN4|uniprotkb:Q5UCD2 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:ki3s1_human(display_long)|uniprotkb:NKAT10(gene name synonym)|uniprotkb:KIR3DS1(gene name)|psi-mi:KIR3DS1(display_short)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 10(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948384|imex:IM-25702-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T ensembl:ENSG00000275434(gene)|ensembl:ENST00000614217(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032393"(MHC class I receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-2172127|refseq:NP_001077008.1|refseq:NP_001269099.1|refseq:NP_001269100.1|refseq:XP_016885749.1 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 6B-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:R2J4hkTBY2PxIlk7zfIMrs2ej8o9606 rigid:w5Pq4xmfnmlDHyrQjybYiXEzaxY false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 flag tag:n-n|variant:13-13,157-157,159-159 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:P61769-PRO_0000018779 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13942645 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948384|imex:IM-25702-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T intact:EBI-714718(chain-parent) - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." chain-seq-start:21|chain-seq-end:119 figure legend:Figure 6B-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606 rigid:w5Pq4xmfnmlDHyrQjybYiXEzaxY false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1-99 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:I4ENP2 uniprotkb:O89940 intact:EBI-6163561|uniprotkb:O62917|uniprotkb:P30497|uniprotkb:P79496|uniprotkb:Q29679|uniprotkb:Q5QT24 intact:EBI-13948404 psi-mi:1b57_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:Bw-57(gene name synonym)|uniprotkb:HLAB(gene name synonym)|uniprotkb:MHC class I antigen B*57(gene name synonym) psi-mi:pol_hv1se(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:"MI:0054"(fluorescence-activated cell sorting) O'Connor et al. (2015) imex:IM-25702|pubmed:25740999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:388824(isolate SE6165)|taxid:388824(Human immunodeficiency virus type 1 group M subtype G) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-13948384|imex:IM-25702-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:5T6Y|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5U98|rcsb pdb:3WUW|ensembl:ENSG00000224608|ensembl:ENSP00000405178|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|uniprotkb:P01889(see-also)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:2HJL|rcsb pdb:2RFX|rcsb pdb:3VH8|go:"GO:0009986"(cell surface)|rcsb pdb:3UPR|rcsb pdb:3VRI|rcsb pdb:3VRJ|rcsb pdb:5T6W|rcsb pdb:5T6X|rcsb pdb:2YPK|rcsb pdb:2YPL|go:"GO:0042605"(peptide antigen binding)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6BXP|rcsb pdb:6BXQ|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000435618|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5V5M|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5VUF|rcsb pdb:6D29|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T go:"GO:0003723"(RNA binding)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0008289"(lipid binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0015074"(DNA integration)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075713"(establishment of integrated proviral latency)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0003677"(DNA binding)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR034170|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR018061|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR002156(Ribonuclease H)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|interpro:IPR043502|interpro:IPR043128 - no-uniprot-update:|caution:"The protein could not be merged with EBI-1046513 because of some conflicts with the protein sequence (features which cannot be shifted)." - figure legend:Figure 6B-2|comment:"B5701 allele;KIR3DS1 variant (3DS1*014) (Genbank:AY760033/AAV32446.1)"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/03/06 2017/10/30 rogid:x0dOWdHQKXpKleDLGPQxYfSGjLI9606 rogid:ELFfkcHRJrtWFT0dq11sLA4cnq0388824 rigid:w5Pq4xmfnmlDHyrQjybYiXEzaxY false red fluorescent protein tag:?-?|sufficient binding region:25..25-308..308 sufficient binding region:1269-1277 4 - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)