#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56704	uniprotkb:Q6P988	intact:EBI-6173037|ensembl:ENSP00000284523|uniprotkb:Q3SY80|uniprotkb:Q969P2|uniprotkb:Q3SY79	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	psi-mi:wnt3a_human(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short)	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:"MI:0406"(deacetylase assay)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147081|imex:IM-24406-2|dip:DIP-199050E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000154342(gene)|ensembl:ENST00000284523(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0005576"(extracellular region)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-201681|reactome:R-HSA-3238698|reactome:R-HSA-373080|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588|refseq:NP_149122.1|dip:DIP-58592N	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:rYpTGWi5cUzJcIyzMor27nheDOE9606	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rigid:C2BT1jdvlipKKjGc8ElI/HrardM	false	sufficient binding region:205-215	sufficient binding region:81-451|mutation disrupting interaction rate:232-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51654-1	uniprotkb:Q6P988	intact:EBI-16147051|ensembl:ENSP00000359854	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	psi-mi:p51654-1(display_long)|uniprotkb:GPC3(gene name)|psi-mi:GPC3(display_short)|uniprotkb:OCI5(gene name synonym)|uniprotkb:GTR2-2(gene name synonym)|uniprotkb:Intestinal protein OCI-5(gene name synonym)|uniprotkb:MXR7(gene name synonym)	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147060|imex:IM-24406-1|dip:DIP-199048E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-5654198(isoform-parent)|ensembl:ENSG00000147257(gene)|ensembl:ENST00000370818(transcript)	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:+H2PtA0Y61S+2l56UPxwxBpCosc9606	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rigid:DpzkQUSSvwYN+ZZM8HJe4O0RiMM	false	sufficient binding region:31-538	sufficient binding region:81-451	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P988	uniprotkb:Q6P988	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147116|imex:IM-24406-3|dip:DIP-199053E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rigid:hIrzaXhzlQMwNEuVxS/W8+1uMog	false	sufficient binding region:81-451	sufficient binding region:81-451	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27467	uniprotkb:Q6P988	intact:EBI-2899665|ensembl:ENSMUSP00000010044	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym)	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:"MI:0406"(deacetylase assay)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147155|imex:IM-24406-5|dip:DIP-199049E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rigid:BF26icz9YFPaJn5zclbVBswfnDQ	false	-	sufficient binding region:81-451	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VUX3	uniprotkb:Q9VUX3	intact:EBI-3412154|uniprotkb:Q8T385|ensemblmetazoa:FBpp0075193	intact:EBI-3412154|uniprotkb:Q8T385|ensemblmetazoa:FBpp0075193	psi-mi:notum_drome(display_long)|uniprotkb:Notum(gene name)|psi-mi:Notum(display_short)|uniprotkb:wf(gene name synonym)|uniprotkb:CG13076(orf name)|uniprotkb:Protein Notum(gene name synonym)|uniprotkb:Protein wingful(gene name synonym)|uniprotkb:dNOTUM(gene name synonym)	psi-mi:notum_drome(display_long)|uniprotkb:Notum(gene name)|psi-mi:Notum(display_short)|uniprotkb:wf(gene name synonym)|uniprotkb:CG13076(orf name)|uniprotkb:Protein Notum(gene name synonym)|uniprotkb:Protein wingful(gene name synonym)|uniprotkb:dNOTUM(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147136|imex:IM-24406-4|dip:DIP-199051E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_730096.2|flybase:FBgn0044028|ensemblmetazoa:FBgn0044028(gene)|ensemblmetazoa:FBtr0075435(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006507"(GPI anchor release)|go:"GO:0007419"(ventral cord development)|go:"GO:0009986"(cell surface)|rcsb pdb:4UZJ|rcsb pdb:4UZK|go:"GO:0016055"(Wnt signaling pathway)|reactome:R-DME-381426|reactome:R-DME-5362798|reactome:R-DME-8957275|go:"GO:0035220"(wing disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|dip:DIP-61510N	refseq:NP_730096.2|flybase:FBgn0044028|ensemblmetazoa:FBgn0044028(gene)|ensemblmetazoa:FBtr0075435(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006507"(GPI anchor release)|go:"GO:0007419"(ventral cord development)|go:"GO:0009986"(cell surface)|rcsb pdb:4UZJ|rcsb pdb:4UZK|go:"GO:0016055"(Wnt signaling pathway)|reactome:R-DME-381426|reactome:R-DME-5362798|reactome:R-DME-8957275|go:"GO:0035220"(wing disc development)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048076"(regulation of compound eye pigmentation)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|dip:DIP-61510N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:ozOo4HHZ/o+xTX+2t0fwR/e8qrc7227	rogid:ozOo4HHZ/o+xTX+2t0fwR/e8qrc7227	rigid:ZS/FvejUDzZliQMs0rS+a6SJgZs	false	sufficient binding region:82-415,598-617	sufficient binding region:82-415,598-617	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00755	uniprotkb:Q6P988	intact:EBI-727198|uniprotkb:Q9Y560|uniprotkb:Q96H90|ensembl:ENSP00000285018	intact:EBI-16147014|ensembl:ENSP00000387310|uniprotkb:Q8N410|uniprotkb:Q8NI82	psi-mi:wnt7a_human(display_long)|uniprotkb:WNT7A(gene name)|psi-mi:WNT7A(display_short)	psi-mi:notum_human(display_long)|uniprotkb:NOTUM(gene name)|psi-mi:NOTUM(display_short)|uniprotkb:hNOTUM(gene name synonym)|uniprotkb:OK/SW-CL.30(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Kakugawa et al. (2015)	pubmed:25731175|doi:"https://doi.org/10.1038/nature14259"|imex:IM-24406	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16147175|imex:IM-24406-6|dip:DIP-199052E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004616.2|ensembl:ENSG00000154764(gene)|ensembl:ENST00000285018(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007548"(sex differentiation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045165"(cell fate commitment)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0045167"(asymmetric protein localization involved in cell fate determination)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0062009"(secondary palate development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048864"(stem cell development)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099068"(postsynapse assembly)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:1904861"(excitatory synapse assembly)|go:"GO:1904891"(positive regulation of excitatory synapse assembly)|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR005817(Wnt superfamily)|interpro:IPR013300(Wnt-7 protein)|interpro:IPR018161|interpro:IPR043158|rcsb pdb:4UZQ|reactome:R-HSA-3238698|reactome:R-HSA-373080|dip:DIP-61511N	ensembl:ENSG00000185269(gene)|ensembl:ENST00000409678(transcript)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0060348"(bone development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990697"(protein depalmitoleylation)|go:"GO:1990699"(palmitoleyl hydrolase activity)|interpro:IPR004963(Pectinacetylesterase)|rcsb pdb:4UYU|rcsb pdb:4UYW|rcsb pdb:4UYZ|rcsb pdb:4UZ1|rcsb pdb:4UZ5|rcsb pdb:4UZ6|rcsb pdb:4UZ7|rcsb pdb:4UZ9|rcsb pdb:4UZA|rcsb pdb:4UZL|rcsb pdb:4UZQ|rcsb pdb:4WBH|rcsb pdb:6R8P|rcsb pdb:6R8Q|rcsb pdb:6R8R|rcsb pdb:6T2H|rcsb pdb:6T2K|rcsb pdb:6TR5|rcsb pdb:6TR6|rcsb pdb:6TR7|rcsb pdb:6TUZ|rcsb pdb:6TV4|rcsb pdb:6YSK|rcsb pdb:6YUW|rcsb pdb:6YUY|rcsb pdb:6YV0|rcsb pdb:6YV2|rcsb pdb:6YV4|rcsb pdb:6YXI|rcsb pdb:6ZUV|rcsb pdb:6ZVL|rcsb pdb:6ZYF|reactome:R-HSA-381426|reactome:R-HSA-5362798|reactome:R-HSA-8957275|refseq:NP_848588.3|dip:DIP-61508N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:dydZ+HONRF0rd3v9Za9GTgBOlkU9606	rogid:CIVTrgrkqvEU9SZiwE2PCzN6xB49606	rigid:xgmaZ8GZeGgB9CnZuH7iyJ8wAnQ	false	sufficient binding region:202-209	sufficient binding region:81-451	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)