#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P42566-1 uniprotkb:P26045 intact:EBI-15895294|ensembl:ENSP00000360798 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146671|imex:IM-24219-1|dip:DIP-198745E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:827/uAmI5eQwt2n9FmLaYNuyQPQ false sufficient binding region:846-854|O4'-phospho-L-tyrosine:849-849 sufficient binding region:628-909 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12923 uniprotkb:P42566-1 intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249 intact:EBI-15895294|ensembl:ENSP00000360798 psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym) psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146717|imex:IM-24219-3|dip:DIP-198747E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rigid:fD7ea6vKd01MRTkWtI/a8fqDgLg false sufficient binding region:2163-2467 sufficient binding region:846-854|O4'-phospho-L-tyrosine:849-849 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42566-1 uniprotkb:P26045 intact:EBI-15895294|ensembl:ENSP00000360798 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16146694|imex:IM-24219-2|dip:DIP-198745E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:827/uAmI5eQwt2n9FmLaYNuyQPQ false flag tag:?-? ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P53778 uniprotkb:P26045 intact:EBI-602406|uniprotkb:Q6IC53|uniprotkb:Q14260|uniprotkb:Q99588|uniprotkb:Q99672|ensembl:ENSP00000215659 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:mk12_human(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:MAPK12(gene name)|psi-mi:MAPK12(display_short)|uniprotkb:ERK6(gene name synonym)|uniprotkb:SAPK3(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146820|imex:IM-24219-7|dip:DIP-198748E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001290181.1|refseq:NP_002960.2|dip:DIP-34241N|ensembl:ENSG00000188130(gene)|ensembl:ENST00000215659(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|mint:P53778|rcsb pdb:1CM8|rcsb pdb:4QUM|rcsb pdb:6UNA|rcsb pdb:7CGA|reactome:R-HSA-168638|reactome:R-HSA-171007|reactome:R-HSA-2151209|reactome:R-HSA-376172|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5675221 refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:S+3tRoF9CGZSsMEsejxLUOpMN5g9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:zhV0Fr8vRYnd9bWTbqHcyhNKOkE false sufficient binding region:182-188|O4'-phospho-L-tyrosine:185-185|O-phospho-L-threonine:183-183 sufficient binding region:628-909|mutation disrupting interaction rate:676-676 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42566-1 uniprotkb:P26045 intact:EBI-15895294|ensembl:ENSP00000360798 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146793|imex:IM-24219-6|dip:DIP-198745E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:827/uAmI5eQwt2n9FmLaYNuyQPQ false sufficient binding region:846-854|O4'-phospho-L-tyrosine:849-849 sufficient binding region:628-909|mutation disrupting interaction rate:676-676 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06213-1 uniprotkb:P26045 intact:EBI-15558981|ensembl:ENSP00000303830 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146767|imex:IM-24219-5|dip:DIP-198749E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:AIsWLbOqfaJOaDNDY0gK+Dkh5Rw false sufficient binding region:1186-1198|O4'-phospho-L-tyrosine:1189-1189 sufficient binding region:628-909|mutation disrupting interaction rate:676-676 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P42566-1 uniprotkb:P26045 intact:EBI-15895294|ensembl:ENSP00000360798 intact:EBI-1047946|uniprotkb:A0AUW9|uniprotkb:E7EN99|uniprotkb:E9PGU7|ensembl:ENSP00000363667 psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:ptn3_human(display_long)|uniprotkb:Protein-tyrosine phosphatase H1(gene name synonym)|uniprotkb:PTPN3(gene name)|psi-mi:PTPN3(display_short)|uniprotkb:PTPH1(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146740|imex:IM-24219-4|dip:DIP-198745E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) refseq:NP_001138840.1|refseq:NP_001138843.1|refseq:NP_002820.3|refseq:NP_001138841.1|refseq:NP_001138842.1|refseq:XP_011517191.1|refseq:XP_016870444.1|refseq:XP_016870446.1|ensembl:ENSG00000070159(gene)|ensembl:ENST00000374541(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051117"(ATPase binding)|go:"GO:0097421"(liver regeneration)|go:"GO:0098902"(regulation of membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012151(Protein-tyrosine phosphatase, non-receptor type-3, -4)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041783|mint:P26045|rcsb pdb:2B49|rcsb pdb:4QUM|rcsb pdb:4QUN|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4RI4|rcsb pdb:4RI5|rcsb pdb:4S0G|rcsb pdb:6HKS|rcsb pdb:6T36|reactome:R-HSA-182971|reactome:R-HSA-5675221|refseq:XP_006717262.1|refseq:XP_006717267.1|dip:DIP-38839N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rogid:7LM4ANS9aclQf1SZfn/Jmxj2fUA9606 rigid:827/uAmI5eQwt2n9FmLaYNuyQPQ false sufficient binding region:846-854|O4'-phospho-L-tyrosine:849-849|fluorescein isothiocyanate label:?-? sufficient binding region:628-909 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18031 uniprotkb:P42566-1 intact:EBI-968788|ensembl:ENSP00000360683|uniprotkb:Q5TGD8|uniprotkb:Q9BQV9|uniprotkb:Q9NQQ4 intact:EBI-15895294|ensembl:ENSP00000360798 psi-mi:ptn1_human(display_long)|uniprotkb:PTPN1(gene name)|psi-mi:PTPN1(display_short)|uniprotkb:PTP1B(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1B(gene name synonym) psi-mi:p42566-1(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chen et al. (2015) pubmed:25728925|doi:10.1016/j.str.2015.01.017|imex:IM-24219 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16146848|imex:IM-24219-8|dip:DIP-198746E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196396(gene)|ensembl:ENST00000371621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097443"(sorting endosome)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:1990264"(peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P18031|rcsb pdb:1A5Y|rcsb pdb:1BZC|rcsb pdb:1BZH|rcsb pdb:1BZJ|rcsb pdb:1C83|rcsb pdb:1C84|rcsb pdb:1C85|rcsb pdb:1C86|rcsb pdb:1C87|rcsb pdb:1C88|rcsb pdb:1ECV|rcsb pdb:1EEN|rcsb pdb:1EEO|rcsb pdb:1G1F|rcsb pdb:1AAX|rcsb pdb:1G1G|rcsb pdb:1G1H|rcsb pdb:1G7F|rcsb pdb:1G7G|rcsb pdb:1GFY|rcsb pdb:1I57|rcsb pdb:1JF7|rcsb pdb:5QFV|rcsb pdb:5QFW|rcsb pdb:5QFX|rcsb pdb:5QFY|rcsb pdb:5QFZ|rcsb pdb:5QG0|rcsb pdb:5QG1|rcsb pdb:5QG2|rcsb pdb:5QG3|rcsb pdb:5QG4|rcsb pdb:5QG5|rcsb pdb:5QG6|rcsb pdb:5QG7|rcsb pdb:5QG8|rcsb pdb:5QG9|rcsb pdb:5QGA|rcsb pdb:5QGB|rcsb pdb:5QGC|rcsb pdb:5QGD|rcsb pdb:5QGE|rcsb pdb:5QGF|rcsb pdb:5T19|rcsb pdb:6B8E|rcsb pdb:6B8T|rcsb pdb:6B8X|rcsb pdb:6B8Z|rcsb pdb:6B90|rcsb pdb:6B95|rcsb pdb:6BAI|rcsb pdb:6CWU|rcsb pdb:6CWV|rcsb pdb:6NTP|rcsb pdb:6OL4|rcsb pdb:6OLQ|rcsb pdb:6OLV|rcsb pdb:1KAK|rcsb pdb:1KAV|rcsb pdb:1L8G|rcsb pdb:1LQF|rcsb pdb:1NL9|rcsb pdb:1NNY|rcsb pdb:1NO6|rcsb pdb:1NWE|rcsb pdb:1NWL|rcsb pdb:1NZ7|rcsb pdb:1OEM|rcsb pdb:1OEO|rcsb pdb:1OES|rcsb pdb:1OET|rcsb pdb:1OEU|rcsb pdb:1OEV|rcsb pdb:1ONY|rcsb pdb:1ONZ|rcsb pdb:1PA1|rcsb pdb:1PH0|rcsb pdb:1PTT|rcsb pdb:1PTU|rcsb pdb:1PTV|rcsb pdb:1PTY|rcsb pdb:1PXH|rcsb pdb:1PYN|rcsb pdb:1Q1M|rcsb pdb:1Q6J|rcsb pdb:1Q6M|rcsb pdb:1Q6N|rcsb pdb:1Q6P|rcsb pdb:1Q6S|rcsb pdb:1Q6T|rcsb pdb:1QXK|rcsb pdb:1SUG|rcsb pdb:1T48|rcsb pdb:1T49|rcsb pdb:1T4J|rcsb pdb:1WAX|rcsb pdb:1XBO|rcsb pdb:2AZR|rcsb pdb:2B07|rcsb pdb:2B4S|rcsb pdb:2BGD|rcsb pdb:2NT7|rcsb pdb:2BGE|rcsb pdb:2CM2|rcsb pdb:2NTA|rcsb pdb:2CM3|rcsb pdb:2CM7|rcsb pdb:2QBP|rcsb pdb:2CM8|rcsb pdb:2CMA|rcsb pdb:2QBQ|rcsb pdb:2QBR|rcsb pdb:2CMB|rcsb pdb:2CMC|rcsb pdb:2CNE|rcsb pdb:2QBS|rcsb pdb:2CNF|rcsb pdb:2CNG|rcsb pdb:2CNH|rcsb pdb:2CNI|rcsb pdb:2F6F|rcsb pdb:2F6T|rcsb pdb:2VEU|rcsb pdb:2F6V|rcsb pdb:2F6W|rcsb pdb:2F6Y|rcsb pdb:2VEV|rcsb pdb:2VEW|rcsb pdb:2VEX|rcsb pdb:2VEY|rcsb pdb:2F6Z|rcsb pdb:2ZMM|rcsb pdb:2F70|rcsb pdb:2F71|rcsb pdb:2ZN7|rcsb pdb:3A5J|rcsb pdb:2FJM|rcsb pdb:2FJN|rcsb pdb:2H4G|rcsb pdb:2H4K|rcsb pdb:2HB1|rcsb pdb:2HNP|rcsb pdb:2HNQ|rcsb pdb:3A5K|rcsb pdb:3CWE|rcsb pdb:6OMY|rcsb pdb:3D9C|rcsb pdb:3EAX|rcsb pdb:4QAP|rcsb pdb:4QBE|rcsb pdb:3EB1|rcsb pdb:4QBW|rcsb pdb:4Y14|rcsb pdb:4ZRT|rcsb pdb:5K9V|rcsb pdb:5K9W|rcsb pdb:5KA0|rcsb pdb:5KA1|rcsb pdb:5KA2|rcsb pdb:5KA3|rcsb pdb:5KA4|rcsb pdb:5KA7|rcsb pdb:5KA8|rcsb pdb:5KA9|rcsb pdb:5KAA|rcsb pdb:5KAB|rcsb pdb:5KAC|rcsb pdb:5KAD|rcsb pdb:5QDE|rcsb pdb:5QDF|rcsb pdb:5QDG|rcsb pdb:5QDH|rcsb pdb:5QDI|rcsb pdb:5QDJ|rcsb pdb:5QDK|rcsb pdb:5QDL|rcsb pdb:5QDM|rcsb pdb:5QDN|rcsb pdb:3EU0|rcsb pdb:3I7Z|rcsb pdb:3I80|rcsb pdb:3QKP|rcsb pdb:3QKQ|rcsb pdb:3SME|rcsb pdb:3ZMP|rcsb pdb:3ZMQ|rcsb pdb:3ZV2|rcsb pdb:4BJO|rcsb pdb:4I8N|rcsb pdb:4QAH|rcsb pdb:5QDO|rcsb pdb:5QDP|rcsb pdb:5QDQ|rcsb pdb:5QDR|rcsb pdb:5QDS|rcsb pdb:6PG0|rcsb pdb:6PGT|rcsb pdb:6PHA|rcsb pdb:6PHS|rcsb pdb:6PM8|rcsb pdb:6W30|rcsb pdb:7KEN|rcsb pdb:7L0C|rcsb pdb:7L0H|rcsb pdb:7LFO|rcsb pdb:7MM1|reactome:R-HSA-354192|reactome:R-HSA-6807004|reactome:R-HSA-877312|reactome:R-HSA-8849472|reactome:R-HSA-9022699|reactome:R-HSA-912694|reactome:R-HSA-982772|rcsb pdb:6PFW|rcsb pdb:5QDW|rcsb pdb:5QDX|rcsb pdb:5QDY|rcsb pdb:5QDZ|rcsb pdb:5QE0|rcsb pdb:5QE1|rcsb pdb:5QDT|rcsb pdb:5QDU|rcsb pdb:5QE2|rcsb pdb:5QE3|rcsb pdb:5QE4|rcsb pdb:5QE5|rcsb pdb:5QE6|rcsb pdb:5QE7|rcsb pdb:5QE8|rcsb pdb:5QE9|rcsb pdb:5QEA|rcsb pdb:5QEB|rcsb pdb:5QEC|rcsb pdb:5QED|rcsb pdb:5QEE|rcsb pdb:5QEF|rcsb pdb:5QEG|rcsb pdb:5QEH|rcsb pdb:5QEI|rcsb pdb:5QEJ|rcsb pdb:5QDV|rcsb pdb:5QEK|rcsb pdb:5QEL|rcsb pdb:5QEM|rcsb pdb:5QEN|rcsb pdb:5QEO|rcsb pdb:5QEP|rcsb pdb:5QEQ|rcsb pdb:5QER|rcsb pdb:5QES|rcsb pdb:5QET|rcsb pdb:5QEU|rcsb pdb:5QEV|rcsb pdb:5QEW|rcsb pdb:5QEX|rcsb pdb:5QEY|rcsb pdb:5QEZ|rcsb pdb:5QF0|rcsb pdb:5QF1|rcsb pdb:5QF2|rcsb pdb:5QF3|rcsb pdb:5QF4|rcsb pdb:5QF5|rcsb pdb:5QF6|rcsb pdb:5QF7|rcsb pdb:5QF8|rcsb pdb:5QF9|rcsb pdb:5QFA|rcsb pdb:5QFB|rcsb pdb:5QFC|rcsb pdb:5QFD|rcsb pdb:5QFE|rcsb pdb:5QFF|rcsb pdb:5QFG|rcsb pdb:5QFH|rcsb pdb:5QFI|rcsb pdb:5QFJ|rcsb pdb:5QFK|rcsb pdb:5QFL|rcsb pdb:5QFM|rcsb pdb:5QFN|rcsb pdb:5QFO|rcsb pdb:5QFP|rcsb pdb:5QFQ|rcsb pdb:5QFR|rcsb pdb:5QFS|rcsb pdb:5QFT|rcsb pdb:5QFU|refseq:NP_001265547.1|refseq:NP_002818.1|dip:DIP-38014N ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|intact:EBI-396684(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:yz+WjBWu7IXrpAfeMUJ2s0e0ACM9606 rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606 rigid:TNyD/amISN8nAD6ElhrvbaXQpKY false sufficient binding region:1-320 sufficient binding region:846-854|O4'-phospho-L-tyrosine:849-849 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)