#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99ZW2	uniprotkb:Q99YS8	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146350|ensemblbacteria:AAK34348|uniprotkb:Q48XM2	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:q99ys8_strp1(display_long)|uniprotkb:cas2(gene name)|psi-mi:cas2(display_short)|uniprotkb:SPy_1561(locus name)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146368|imex:IM-24405-1|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK34348(transcript)|ensemblbacteria:SPy_1561(gene)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR019199|interpro:IPR021127|rcsb pdb:4QR0|rcsb pdb:4QR1|rcsb pdb:4QR2|dip:DIP-61507N|refseq:NP_269627.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:w2LHpbeU9fBqs9/qc0RtwfnTcWk301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZW2	uniprotkb:Q99ZW1	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146368|imex:IM-24405-1|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZW2	uniprotkb:Q99ZV9	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146368|imex:IM-24405-1|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:n-n	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZW2	uniprotkb:Q99ZV9	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:"MI:0226"(ion exchange chromatography)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146389|imex:IM-24405-2|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZW2	uniprotkb:Q99YS8	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146350|ensemblbacteria:AAK34348|uniprotkb:Q48XM2	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:q99ys8_strp1(display_long)|uniprotkb:cas2(gene name)|psi-mi:cas2(display_short)|uniprotkb:SPy_1561(locus name)	psi-mi:"MI:0226"(ion exchange chromatography)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146389|imex:IM-24405-2|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK34348(transcript)|ensemblbacteria:SPy_1561(gene)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR019199|interpro:IPR021127|rcsb pdb:4QR0|rcsb pdb:4QR1|rcsb pdb:4QR2|dip:DIP-61507N|refseq:NP_269627.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:w2LHpbeU9fBqs9/qc0RtwfnTcWk301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZW2	uniprotkb:Q99ZW1	intact:EBI-16146275|ensemblbacteria:AAK33936	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0226"(ion exchange chromatography)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146389|imex:IM-24405-2|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZV9	uniprotkb:Q99YS8	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146350|ensemblbacteria:AAK34348|uniprotkb:Q48XM2	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99ys8_strp1(display_long)|uniprotkb:cas2(gene name)|psi-mi:cas2(display_short)|uniprotkb:SPy_1561(locus name)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146408|imex:IM-24405-3|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK34348(transcript)|ensemblbacteria:SPy_1561(gene)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR019199|interpro:IPR021127|rcsb pdb:4QR0|rcsb pdb:4QR1|rcsb pdb:4QR2|dip:DIP-61507N|refseq:NP_269627.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:w2LHpbeU9fBqs9/qc0RtwfnTcWk301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZV9	uniprotkb:Q99ZW1	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146333|ensemblbacteria:AAK33937|uniprotkb:Q48Z30	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:q99zw1_strp1(display_long)|uniprotkb:cas1(gene name)|psi-mi:cas1(display_short)|uniprotkb:SPy_1047(locus name)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146408|imex:IM-24405-3|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33937(transcript)|ensemblbacteria:SPy_1047(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR002729(Protein of unknown function DUF48)|interpro:IPR019855|interpro:IPR042206|dip:DIP-61506N|refseq:NP_269216.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:EGMFI3jccjLiPk7Ogr9u5131AG0301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q99ZV9	uniprotkb:Q99ZW2	intact:EBI-16146316|ensemblbacteria:AAK33939|uniprotkb:Q48Z28	intact:EBI-16146275|ensemblbacteria:AAK33936	psi-mi:csn2_strp1(display_long)|uniprotkb:csn2(gene name)|psi-mi:csn2(display_short)|uniprotkb:M5005_Spy0772(locus name)|uniprotkb:SPy_1049(locus name)	psi-mi:cas9_strp1(display_long)|uniprotkb:cas9(gene name)|psi-mi:cas9(display_short)|uniprotkb:csn1(gene name synonym)|uniprotkb:SPy_1046(locus name)|uniprotkb:SpCas9(gene name synonym)|uniprotkb:SpyCas9(gene name synonym)	psi-mi:"MI:0096"(pull down)	Heler et al. (2015)	pubmed:25707807|doi:10.1038/nature14245|imex:IM-24405	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	taxid:301447(strp1)|taxid:301447(Streptococcus pyogenes serotype M1)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16146408|imex:IM-24405-3|dip:DIP-199047E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAK33939(transcript)|ensemblbacteria:SPy_1049(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR010146(CRISPR-associated protein, SAG0897)|interpro:IPR038600|rcsb pdb:3TOC|rcsb pdb:3V7F|dip:DIP-61505N|refseq:NP_269218.1	ensemblbacteria:AAK33936(transcript)|ensemblbacteria:SPy_1046(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0043571"(maintenance of CRISPR repeat elements)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003615(HNH nuclease)|interpro:IPR028629|interpro:IPR032237|interpro:IPR032239|interpro:IPR032240|interpro:IPR033114|interpro:IPR036397|rcsb pdb:4CMP|rcsb pdb:4CMQ|rcsb pdb:4OO8|rcsb pdb:4UN3|rcsb pdb:4UN4|rcsb pdb:4UN5|rcsb pdb:4ZT0|rcsb pdb:4ZT9|rcsb pdb:5B2R|rcsb pdb:5B2S|rcsb pdb:5B2T|rcsb pdb:5F9R|rcsb pdb:5FQ5|rcsb pdb:5FW1|rcsb pdb:5FW2|rcsb pdb:5VW1|rcsb pdb:5VZL|rcsb pdb:5XBL|rcsb pdb:5Y36|rcsb pdb:6AEB|rcsb pdb:6AEG|rcsb pdb:6AI6|rcsb pdb:6IFO|rcsb pdb:6K3Z|rcsb pdb:6K4P|rcsb pdb:6K4Q|rcsb pdb:6K4S|rcsb pdb:6K4U|rcsb pdb:6K57|rcsb pdb:6O0X|rcsb pdb:6O0Y|rcsb pdb:6O0Z|rcsb pdb:6O56|rcsb pdb:6VPC|rcsb pdb:5FW3|dip:DIP-61504N|refseq:NP_269215.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:5S8WEQT9NDkUSBDi+gQEM7L7kus301447	rogid:eTbuXzxdPaPSKSrVTZ3dVTCoZpI301447	rigid:jSIQAUVe7vrEJ4ghmi6Vlh1pTWM	false	his tag:c-c	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)