#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-4399559	uniprotkb:P40087	dip:DIP-24261N	intact:EBI-5717|uniprotkb:D3DM50|ensemblfungi:YER143W	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ddi1_yeast(display_long)|uniprotkb:DDI1(gene name)|psi-mi:DDI1(display_short)|uniprotkb:v-SNARE-master 1(gene name synonym)|uniprotkb:VSM1(gene name synonym)|uniprotkb:YER143W(locus name)	psi-mi:"MI:0096"(pull down)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145330|imex:IM-24216-1|dip:DIP-198739E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	sgd:S000000945|refseq:NP_011070.3|dip:DIP-1216N|mint:P40087|rcsb pdb:2MRP|rcsb pdb:2MWS|rcsb pdb:2N7E|rcsb pdb:4Z2Z|rcsb pdb:5KES|ensemblfungi:YER143W(gene)|ensemblfungi:YER143W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:1904855"(proteasome regulatory particle binding)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019103|interpro:IPR021109|interpro:IPR033882|rcsb pdb:2I1A|rcsb pdb:2MR9|rcsb pdb:2MRO	psi-mi:"MI:0465"(dip)	no-uniprot-update:	crc64:B43425B029B7658B	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:DHcLrKv/gQNKEXCievX6k6ikKL0559292	rigid:iptUdsFYPn+RvtMjul9ngGHUaio	false	his tag:0-0	sufficient binding region:2-80|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:P40087	dip:DIP-24261N	intact:EBI-5717|uniprotkb:D3DM50|ensemblfungi:YER143W	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ddi1_yeast(display_long)|uniprotkb:DDI1(gene name)|psi-mi:DDI1(display_short)|uniprotkb:v-SNARE-master 1(gene name synonym)|uniprotkb:VSM1(gene name synonym)|uniprotkb:YER143W(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145373|imex:IM-24216-3|dip:DIP-198739E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	sgd:S000000945|refseq:NP_011070.3|dip:DIP-1216N|mint:P40087|rcsb pdb:2MRP|rcsb pdb:2MWS|rcsb pdb:2N7E|rcsb pdb:4Z2Z|rcsb pdb:5KES|ensemblfungi:YER143W(gene)|ensemblfungi:YER143W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:1904855"(proteasome regulatory particle binding)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019103|interpro:IPR021109|interpro:IPR033882|rcsb pdb:2I1A|rcsb pdb:2MR9|rcsb pdb:2MRO	psi-mi:"MI:0465"(dip)	no-uniprot-update:	crc64:B43425B029B7658B	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:DHcLrKv/gQNKEXCievX6k6ikKL0559292	rigid:iptUdsFYPn+RvtMjul9ngGHUaio	false	-	sufficient binding region:389-428	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:P40087	dip:DIP-24261N	intact:EBI-5717|uniprotkb:D3DM50|ensemblfungi:YER143W	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ddi1_yeast(display_long)|uniprotkb:DDI1(gene name)|psi-mi:DDI1(display_short)|uniprotkb:v-SNARE-master 1(gene name synonym)|uniprotkb:VSM1(gene name synonym)|uniprotkb:YER143W(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145393|imex:IM-24216-4|dip:DIP-198739E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	sgd:S000000945|refseq:NP_011070.3|dip:DIP-1216N|mint:P40087|rcsb pdb:2MRP|rcsb pdb:2MWS|rcsb pdb:2N7E|rcsb pdb:4Z2Z|rcsb pdb:5KES|ensemblfungi:YER143W(gene)|ensemblfungi:YER143W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:1904855"(proteasome regulatory particle binding)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019103|interpro:IPR021109|interpro:IPR033882|rcsb pdb:2I1A|rcsb pdb:2MR9|rcsb pdb:2MRO	psi-mi:"MI:0465"(dip)	no-uniprot-update:	crc64:B43425B029B7658B	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:DHcLrKv/gQNKEXCievX6k6ikKL0559292	rigid:iptUdsFYPn+RvtMjul9ngGHUaio	false	mutation decreasing interaction strength:72-72,6-6,42-42|mutation disrupting interaction strength:72-72,6-6,42-42	sufficient binding region:2-80	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-16145422	uniprotkb:P40087	dip:DIP-61299N	intact:EBI-5717|uniprotkb:D3DM50|ensemblfungi:YER143W	psi-mi:yub(display_short)|psi-mi:EBI-16145422(display_long)	psi-mi:ddi1_yeast(display_long)|uniprotkb:DDI1(gene name)|psi-mi:DDI1(display_short)|uniprotkb:v-SNARE-master 1(gene name synonym)|uniprotkb:VSM1(gene name synonym)|uniprotkb:YER143W(locus name)	psi-mi:"MI:0096"(pull down)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145426|imex:IM-24216-5|dip:DIP-198740E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	sgd:S000000945|refseq:NP_011070.3|dip:DIP-1216N|mint:P40087|rcsb pdb:2MRP|rcsb pdb:2MWS|rcsb pdb:2N7E|rcsb pdb:4Z2Z|rcsb pdb:5KES|ensemblfungi:YER143W(gene)|ensemblfungi:YER143W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:1904855"(proteasome regulatory particle binding)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019103|interpro:IPR021109|interpro:IPR033882|rcsb pdb:2I1A|rcsb pdb:2MR9|rcsb pdb:2MRO	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.	crc64:B43425B029B7658B	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:sUFDb7kGedoC/k80bI4sjOaMLHs559292	rogid:DHcLrKv/gQNKEXCievX6k6ikKL0559292	rigid:XDMAURT8Sm3G/NbR0XRC2cer1Q8	false	-	sufficient binding region:2-80|his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04511	intact:EBI-4399559	intact:EBI-20020|uniprotkb:D6W0J5|ensemblfungi:YML088W	dip:DIP-24261N	psi-mi:ufo1_yeast(display_long)|uniprotkb:UFO1(gene name)|psi-mi:UFO1(display_short)|uniprotkb:YML088W(locus name)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145353|imex:IM-24216-2|dip:DIP-198741E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013622.1|sgd:S000004553|reactome:R-SCE-8951664|reactome:R-SCE-983168|ensemblfungi:YML088W(gene)|ensemblfungi:YML088W_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0071406"(cellular response to methylmercury)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036047|interpro:IPR036322|dip:DIP-1953N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	crc64:10CA467CF9417FBC	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:D+TKd90xJ3SFedFC8rIqP/5c0uc559292	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:fFZTSyHGg9EfT9PrcS9BvfvLCRI	false	sufficient binding region:547-668	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:P40087	dip:DIP-24261N	intact:EBI-5717|uniprotkb:D3DM50|ensemblfungi:YER143W	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ddi1_yeast(display_long)|uniprotkb:DDI1(gene name)|psi-mi:DDI1(display_short)|uniprotkb:v-SNARE-master 1(gene name synonym)|uniprotkb:VSM1(gene name synonym)|uniprotkb:YER143W(locus name)	psi-mi:"MI:0888"(small angle neutron scattering)	Nowicka et al. (2015)	pubmed:25703377|doi:10.1016/j.str.2015.01.010|imex:IM-24216	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145447|imex:IM-24216-6|dip:DIP-198739E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	sgd:S000000945|refseq:NP_011070.3|dip:DIP-1216N|mint:P40087|rcsb pdb:2MRP|rcsb pdb:2MWS|rcsb pdb:2N7E|rcsb pdb:4Z2Z|rcsb pdb:5KES|ensemblfungi:YER143W(gene)|ensemblfungi:YER143W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0009306"(protein secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:1904855"(proteasome regulatory particle binding)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR019103|interpro:IPR021109|interpro:IPR033882|rcsb pdb:2I1A|rcsb pdb:2MR9|rcsb pdb:2MRO	psi-mi:"MI:0465"(dip)	no-uniprot-update:	crc64:B43425B029B7658B	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:DHcLrKv/gQNKEXCievX6k6ikKL0559292	rigid:iptUdsFYPn+RvtMjul9ngGHUaio	false	-	sufficient binding region:2-80	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)