#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-15810615	uniprotkb:P0AEE3	dip:DIP-45824N	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	psi-mi:dnrdgnvyyf(display_short)|psi-mi:EBI-15810615(display_long)	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	de et al. (2015)	pubmed:25703375|doi:"https://doi.org/10.1016/j.str.2015.01.012"|imex:IM-24215	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145229|imex:IM-24215-1|dip:DIP-81438E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bGWaaOKOqg18OKDuq6vMACcRtSY-2	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rigid:PRhBFnPeU+EYEOmF5MoLjIRV5pw	false	fluorescein label:0-0	sufficient binding region:27-355	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AFX7	uniprotkb:P0AEE3	intact:EBI-1117560|uniprotkb:P38106|uniprotkb:Q2MAF8|ensemblbacteria:AAC75625|ensemblbacteria:BAE76748	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	psi-mi:rsea_ecoli(display_long)|uniprotkb:yfiJ(gene name synonym)|uniprotkb:rseA(gene name)|psi-mi:rseA(display_short)|uniprotkb:mclA(gene name synonym)|uniprotkb:b2572(locus name)|uniprotkb:JW2556(locus name)|uniprotkb:Regulator of SigE(gene name synonym)|uniprotkb:Sigma-E anti-sigma factor RseA(gene name synonym)|uniprotkb:Sigma-E factor negative regulatory protein(gene name synonym)	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	de et al. (2015)	pubmed:25703375|doi:"https://doi.org/10.1016/j.str.2015.01.012"|imex:IM-24215	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16145250|imex:IM-24215-2|dip:DIP-81439E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417067.1|ensemblbacteria:AAC75625(transcript)|ensemblbacteria:b2572(gene)|ensemblbacteria:BAE76748(gene)|ensemblbacteria:BAE76748(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016989"(sigma factor antagonist activity)|interpro:IPR005572(Anti sigma-E protein RseA, N-terminal)|interpro:IPR005573(Anti sigma-E protein RseA, C-terminal)|interpro:IPR026279|interpro:IPR036147|rcsb pdb:1OR7|rcsb pdb:1YFN|rcsb pdb:3M4W|refseq:WP_001168459.1|dip:DIP-39581N	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:tpuDQBjnIhDZEQzGSs4rw3+LLcg83333	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rigid:LGzzFprpA8Z0qrqvAPbASa1M3Fw	false	sufficient binding region:121-216	sufficient binding region:27-355|mutation increasing interaction rate:198-198|mutation disrupting interaction rate:161-161|mutation disrupting interaction rate:162-162|mutation disrupting interaction rate:164-164|mutation disrupting interaction rate:167-167|mutation disrupting interaction rate:169-169|mutation disrupting interaction rate:178-178|mutation decreasing interaction rate:179-179|mutation decreasing interaction rate:187-187|mutation decreasing interaction rate:191-191|mutation disrupting interaction rate:197-197|mutation decreasing interaction rate:220-220|mutation decreasing interaction rate:221-221|mutation increasing interaction rate:229-229|mutation decreasing interaction rate:230-230|mutation disrupting interaction rate:232-232|mutation disrupting interaction rate:234-234	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)