#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6IQ20 uniprotkb:Q6IQ20 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Magotti et al. (2015) pubmed:25684574|doi:10.1016/j.str.2014.12.018|imex:IM-24211 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16143196|imex:IM-24211-1|dip:DIP-198734E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rigid:OllRYmtJp/r0IyDDsL18jh7r9rQ false mutation disrupting interaction strength:159-159,158-158|sufficient binding region:47-393 mutation disrupting interaction strength:159-159,158-158|sufficient binding region:47-393 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6IQ20 uniprotkb:Q6IQ20 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis) Magotti et al. (2015) pubmed:25684574|doi:10.1016/j.str.2014.12.018|imex:IM-24211 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16143218|imex:IM-24211-2|dip:DIP-198734E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rigid:OllRYmtJp/r0IyDDsL18jh7r9rQ false mutation disrupting interaction strength:159-159,158-158|sufficient binding region:47-393 mutation disrupting interaction strength:159-159,158-158|sufficient binding region:47-393 - 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q6IQ20 uniprotkb:Q6IQ20 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 intact:EBI-16143143|ensembl:ENSP00000340093|ensembl:ENSP00000392775|ensembl:ENSP00000407112|ensembl:ENSP00000412376|ensembl:ENSP00000419188|ensembl:ENSP00000481285|ensembl:ENSP00000482162|ensembl:ENSP00000487770|ensembl:ENSP00000488504|ensembl:ENSP00000488648|uniprotkb:Q5CZ87|uniprotkb:Q769K1 psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:napep_human(display_long)|uniprotkb:NAPEPLD(gene name)|psi-mi:NAPEPLD(display_short)|uniprotkb:C7orf18(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Magotti et al. (2015) pubmed:25684574|doi:10.1016/j.str.2014.12.018|imex:IM-24211 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16143241|imex:IM-24211-3|dip:DIP-198734E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N ensembl:ENST00000611100(transcript)|ensembl:ENST00000622712(transcript)|ensembl:ENST00000632159(transcript)|ensembl:ENST00000632703(transcript)|ensembl:ENST00000633783(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032052"(bile acid binding)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0070291"(N-acylethanolamine metabolic process)|go:"GO:0070292"(N-acylphosphatidylethanolamine metabolic process)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0102200"(N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity)|go:"GO:1903999"(negative regulation of eating behavior)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR024884|interpro:IPR036866|rcsb pdb:4QN9|reactome:R-HSA-2466712|ensembl:ENSG00000161048(gene)|ensembl:ENSG00000275723(gene)|ensembl:ENST00000341533(transcript)|ensembl:ENST00000417955(transcript)|ensembl:ENST00000422589(transcript)|ensembl:ENST00000427257(transcript)|ensembl:ENST00000465647(transcript)|refseq:NP_001116310.1|refseq:NP_945341.3|refseq:XP_005250271.2|refseq:XP_005250272.1|refseq:XP_005250275.1|refseq:XP_011514235.1|refseq:XP_016867343.1|refseq:XP_016867344.1|dip:DIP-61398N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rogid:uy8zKbMkhxjQaQ6QtC6HAmgR8yo9606 rigid:OllRYmtJp/r0IyDDsL18jh7r9rQ false sufficient binding region:47-393 sufficient binding region:47-393 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)