#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P68135 uniprotkb:Q93KQ6 intact:EBI-367540|uniprotkb:P02568|uniprotkb:P99020 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:acts_rabit(display_long)|uniprotkb:ACTA1(gene name)|psi-mi:ACTA1(display_short)|uniprotkb:ACTA(gene name synonym)|uniprotkb:Alpha-actin-1(gene name synonym) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142698|imex:IM-24436-3|dip:DIP-199130E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4B1Y|rcsb pdb:4B1Z|rcsb pdb:4EAH|rcsb pdb:4GY2|rcsb pdb:4H03|rcsb pdb:4H0T|rcsb pdb:4H0V|rcsb pdb:4H0X|rcsb pdb:4H0Y|rcsb pdb:4K41|rcsb pdb:4K42|rcsb pdb:4K43|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4PL8|rcsb pdb:4V0U|rcsb pdb:4WYB|rcsb pdb:4B1X|rcsb pdb:4Z94|rcsb pdb:5H53|rcsb pdb:5JLF|rcsb pdb:5KG8|rcsb pdb:5MVA|rcsb pdb:5MVY|rcsb pdb:5ONV|rcsb pdb:5OOC|rcsb pdb:5OOD|rcsb pdb:5OOE|rcsb pdb:5OOF|rcsb pdb:5YEE|rcsb pdb:5YPU|rcsb pdb:5ZZA|rcsb pdb:5ZZB|rcsb pdb:6AV9|rcsb pdb:6AVB|rcsb pdb:6BIH|rcsb pdb:6BNO|rcsb pdb:6BNP|rcsb pdb:6BNQ|rcsb pdb:6BNU|rcsb pdb:6BNV|rcsb pdb:5UBO|rcsb pdb:6BNW|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6FHL|rcsb pdb:6FM2|rcsb pdb:6GVC|rcsb pdb:6JBK|rcsb pdb:6JCU|rcsb pdb:6JH8|rcsb pdb:1T44|rcsb pdb:1UY5|rcsb pdb:1WUA|rcsb pdb:1Y64|rcsb pdb:1YXQ|rcsb pdb:2A3Z|rcsb pdb:2A40|rcsb pdb:2A41|rcsb pdb:2A42|rcsb pdb:2A5X|rcsb pdb:2ASM|rcsb pdb:2ASO|rcsb pdb:2ASP|rcsb pdb:2D1K|rcsb pdb:2FF3|rcsb pdb:2FF6|rcsb pdb:2FXU|rcsb pdb:2GWJ|rcsb pdb:2GWK|rcsb pdb:2HMP|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:2Q0R|rcsb pdb:2Q0U|rcsb pdb:2Q1N|go:"GO:0031432"(titin binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032432"(actin filament bundle)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0090131"(mesenchyme migration)|go:"GO:0098723"(skeletal muscle myofibril)|go:"GO:0120081"(obsolete positive regulation of microfilament motor activity)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1ALM|rcsb pdb:1ATN|rcsb pdb:1EQY|rcsb pdb:1ESV|rcsb pdb:1H1V|rcsb pdb:1IJJ|rcsb pdb:1J6Z|rcsb pdb:1KXP|rcsb pdb:1LCU|rcsb pdb:1M8Q|rcsb pdb:1MA9|rcsb pdb:1MVW|rcsb pdb:1NWK|rcsb pdb:1O18|rcsb pdb:1O19|rcsb pdb:1O1A|rcsb pdb:1O1B|rcsb pdb:1O1C|rcsb pdb:1O1D|rcsb pdb:1O1E|rcsb pdb:1O1F|rcsb pdb:1O1G|rcsb pdb:1P8Z|rcsb pdb:1QZ5|rcsb pdb:1QZ6|rcsb pdb:1RDW|rcsb pdb:1RFQ|rcsb pdb:1RGI|rcsb pdb:1LOT|rcsb pdb:1S22|rcsb pdb:1SQK|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001725"(stress fiber)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005884"(actin filament)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031013"(troponin I binding)|rcsb pdb:6KN8|rcsb pdb:6MGO|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6QRI|rcsb pdb:6RSW|rcsb pdb:6T1Y|rcsb pdb:6T20|rcsb pdb:6T23|rcsb pdb:6T24|rcsb pdb:6T25|rcsb pdb:6U96|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|rcsb pdb:6VAU|rcsb pdb:6VEC|rcsb pdb:6W17|rcsb pdb:6W7V|rcsb pdb:6WVT|rcsb pdb:6YP9|rcsb pdb:7AD9|rcsb pdb:7AHN|rcsb pdb:7AHQ|rcsb pdb:7C2F|rcsb pdb:7C2G|rcsb pdb:7C2H|rcsb pdb:7CCC|rcsb pdb:6KN7|rcsb pdb:6JH9|rcsb pdb:3J8K|rcsb pdb:2Q36|rcsb pdb:2Q97|rcsb pdb:2V51|rcsb pdb:2V52|rcsb pdb:2VCP|rcsb pdb:2VYP|rcsb pdb:2W49|rcsb pdb:2W4U|rcsb pdb:2Y83|rcsb pdb:2YJE|rcsb pdb:2YJF|rcsb pdb:2ZWH|rcsb pdb:3B5U|rcsb pdb:3BUZ|rcsb pdb:3CJB|rcsb pdb:2Q31|rcsb pdb:3CJC|rcsb pdb:3DAW|rcsb pdb:3FFK|rcsb pdb:3G37|rcsb pdb:3HBT|rcsb pdb:3J4K|rcsb pdb:3J8A|rcsb pdb:3J8I|rcsb pdb:3J8J|rcsb pdb:3JBJ|rcsb pdb:3JBK|rcsb pdb:3M1F|rcsb pdb:3M3N|rcsb pdb:3M6G|rcsb pdb:3MFP|rcsb pdb:3JBI|rcsb pdb:3MN5|rcsb pdb:3SJH|rcsb pdb:3TPQ|rcsb pdb:3TU5|rcsb pdb:3U8X|rcsb pdb:3U9Z|rcsb pdb:3UE5|rcsb pdb:4A7F|rcsb pdb:4A7H|rcsb pdb:4A7L|rcsb pdb:4A7N|rcsb pdb:4B1V|rcsb pdb:4B1W|mint:P68135|dip:DIP-29021N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:2vZu8ElmMe+6GjKBliCAatNGZR49986 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:kVO0RYTBUeNJc1KM/zWNNfUEo/Y false pyrene label:?-? sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142669|imex:IM-24436-2|dip:DIP-199128E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:2hMtitSf39iKU3slJhOVaapfMzU false pyrene label:?-? sufficient binding region:89-729|mutation disrupting interaction strength:596-596,592-592,588-588|mutation decreasing interaction strength:245-245 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0114"(x-ray crystallography) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142650|imex:IM-24436-1|dip:DIP-199128E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:2hMtitSf39iKU3slJhOVaapfMzU false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:P06396 intact:EBI-16142639 intact:EBI-351506|uniprotkb:Q8WVV7|ensembl:ENSP00000362924|uniprotkb:Q5T0I2|uniprotkb:A8MUD1|uniprotkb:B7Z373|uniprotkb:A2A418|uniprotkb:A8MYN7|uniprotkb:B7Z5V1|uniprotkb:F5H1A8 psi-mi:g3cka6_spofr(display_long) psi-mi:gels_human(display_long)|uniprotkb:GSN(gene name)|psi-mi:GSN(display_short)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:AGEL(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142719|imex:IM-24436-4|dip:DIP-199131E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N refseq:NP_000168.1|refseq:NP_001121134.1|refseq:NP_001121136.1|refseq:NP_001121137.1|refseq:NP_001121138.1|refseq:NP_001121139.1|refseq:NP_937895.1|refseq:XP_011516888.1|refseq:XP_011516889.1|refseq:XP_011516890.1|refseq:XP_011516891.1|refseq:XP_011516892.1|refseq:XP_011516893.1|refseq:XP_011516894.1|refseq:XP_011516895.1|ensembl:ENSG00000148180(gene)|ensembl:ENST00000373818(transcript)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P06396|rcsb pdb:1C0F|rcsb pdb:1C0G|rcsb pdb:1D4X|rcsb pdb:1DEJ|rcsb pdb:1EQY|rcsb pdb:1ESV|rcsb pdb:1H1V|rcsb pdb:1KCQ|rcsb pdb:1MDU|rcsb pdb:1NLV|rcsb pdb:1NM1|rcsb pdb:1NMD|rcsb pdb:1P8X|rcsb pdb:1SOL|rcsb pdb:1T44|rcsb pdb:1YAG|rcsb pdb:1YVN|rcsb pdb:2FF3|rcsb pdb:2FF6|rcsb pdb:2FH1|rcsb pdb:2FH2|rcsb pdb:2FH3|rcsb pdb:2FH4|rcsb pdb:3A5L|rcsb pdb:3A5M|rcsb pdb:3A5N|rcsb pdb:3A5O|rcsb pdb:3CI5|rcsb pdb:3CIP|rcsb pdb:3CJB|rcsb pdb:3CJC|rcsb pdb:3FFK|rcsb pdb:3FFN|rcsb pdb:3TU5|rcsb pdb:4PKG|rcsb pdb:4PKH|rcsb pdb:4PKI|rcsb pdb:4S10|rcsb pdb:4Z94|rcsb pdb:5DD2|rcsb pdb:5FAE|rcsb pdb:5FAF|rcsb pdb:5H3M|rcsb pdb:5H3N|rcsb pdb:5O2Z|rcsb pdb:5UBO|rcsb pdb:5ZZ0|rcsb pdb:6H1F|rcsb pdb:6JCO|rcsb pdb:6JEG|rcsb pdb:6JEH|rcsb pdb:6LJE|rcsb pdb:6LJF|rcsb pdb:6Q9R|rcsb pdb:6Q9Z|rcsb pdb:6QBF|rcsb pdb:1P8Z|rcsb pdb:6QW3|reactome:R-HSA-264870|reactome:R-HSA-6798695|reactome:R-HSA-9662361|reactome:R-HSA-977225|refseq:NP_001244958.1|refseq:NP_001244959.1|refseq:NP_001121135.2|refseq:XP_005252000.1|refseq:XP_005252001.1|refseq:XP_005252002.1|refseq:XP_006717142.1|refseq:XP_016870135.1|refseq:XP_016870136.1|refseq:XP_016870137.1|dip:DIP-2196N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:uACf9A+H6LAOAZSMGYqeDwUL1Mc9606 rigid:WZaL/Tk9SmC76oASlY3ZHll9NZE false - sufficient binding region:76-126 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142719|imex:IM-24436-4|dip:DIP-199131E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:WZaL/Tk9SmC76oASlY3ZHll9NZE false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P23528 uniprotkb:G3CKA6 intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660 intact:EBI-16142639 psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym) psi-mi:g3cka6_spofr(display_long) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142741|imex:IM-24436-5|dip:DIP-199133E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rigid:+ws5NUOWHzQ01mhBsg3PO3oNLnY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P23528 uniprotkb:Q93KQ6 intact:EBI-352733|uniprotkb:Q53Y87|uniprotkb:Q9UCA2|uniprotkb:B3KUQ1|ensembl:ENSP00000309629|ensembl:ENSP00000432660 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:cof1_human(display_long)|uniprotkb:CFL1(gene name)|psi-mi:CFL1(display_short)|uniprotkb:CFL(gene name synonym)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym)|uniprotkb:18 kDa phosphoprotein(gene name synonym) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142741|imex:IM-24436-5|dip:DIP-199133E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005498.1|ensembl:ENSG00000172757(gene)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P23528|rcsb pdb:1Q8G|rcsb pdb:1Q8X|rcsb pdb:3J0S|rcsb pdb:4BEX|rcsb pdb:5HVK|rcsb pdb:5L6W|rcsb pdb:6UBY|rcsb pdb:6UC0|rcsb pdb:6UC4|rcsb pdb:6VAO|reactome:R-HSA-114608|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-399954|reactome:R-HSA-5627117|reactome:R-HSA-8950505|ensembl:ENST00000308162(transcript)|ensembl:ENST00000525451(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0009615"(response to virus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0031258"(lamellipodium membrane)|dip:DIP-33000N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:wgBEUL55sE9G9Be1f/A1OA6KRb49606 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:+ws5NUOWHzQ01mhBsg3PO3oNLnY false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93KQ6 uniprotkb:Q8CIH5 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P18760 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-1183994|ensembl:ENSMUSP00000147514 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:cof1_mouse(display_long)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_031713.1|ensembl:ENSMUSG00000056201(gene)|ensembl:ENSMUST00000209469(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P18760|dip:DIP-38073N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:nw/9u2+2nq9Ef43SapV43MeOtjE10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P13020 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q8K1I7 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70315 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-644195|ensembl:ENSMUSP00000033505 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q0GNC1 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-6908712|uniprotkb:Q14C56|uniprotkb:Q499F7|uniprotkb:Q6P9T3 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:inf2_mouse(display_long)|uniprotkb:Inf2(gene name)|psi-mi:Inf2(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N go:"GO:0003779"(actin binding)|go:"GO:0030036"(actin cytoskeleton organization)|interpro:IPR042201|go:"GO:0031267"(small GTPase binding)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090140"(regulation of mitochondrial fission)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027649|refseq:NP_940803.2|dip:DIP-61548N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:aggZuhV3g76aRx4oCN3VSUPJVFM10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:O08808 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-1026445|ensembl:ENSMUSP00000111297 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70460 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-990384|uniprotkb:Q3UDF1|uniprotkb:Q91VD2|uniprotkb:Q9R214|uniprotkb:Q3TAP0|uniprotkb:Q3TCD2|uniprotkb:Q3U0C2|ensembl:ENSMUSP00000032561 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:vasp_mouse(display_long)|uniprotkb:Vasp(gene name)|psi-mi:Vasp(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N ensembl:ENSMUSG00000030403(gene)|ensembl:ENSMUST00000032561(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P70460|rcsb pdb:2V8C|reactome:R-MMU-376176|reactome:R-MMU-446353|refseq:NP_033525.2|refseq:NP_001268950.1|refseq:NP_001268951.1|dip:DIP-29360N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:AgIQZ6LcYTav4f8CrTLmaO9fpo410090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70429 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-9083035|uniprotkb:Q9ERU8|ensembl:ENSMUSP00000021689 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:evl_mouse(display_long)|uniprotkb:Evl(gene name)|psi-mi:Evl(display_short)|uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_001156866.1|refseq:NP_031991.3|dip:DIP-40886N|ensembl:ENSMUSG00000021262(gene)|ensembl:ENSMUST00000021689(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030168"(platelet activation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0045010"(actin nucleation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034319|interpro:IPR038023|rcsb pdb:1QC6|reactome:R-MMU-376176|reactome:R-MMU-5663220 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:/CnbUQjtMmlqkIf8NxYJIOicIYk10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P62962 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q05144 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-642680|uniprotkb:Q3TBC4|uniprotkb:Q9D8X9|ensembl:ENSMUSP00000036384 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:rac2_mouse(display_long)|uniprotkb:p21-Rac2(gene name synonym)|uniprotkb:Protein EN-7(gene name synonym)|uniprotkb:Rac2(gene name)|psi-mi:Rac2(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142761|imex:IM-24436-6|dip:DIP-199135E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_033034.1|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045453"(bone resorption)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060753"(regulation of mast cell chemotaxis)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q05144|reactome:R-MMU-114604|reactome:R-MMU-1222556|reactome:R-MMU-1257604|reactome:R-MMU-4086400|reactome:R-MMU-5668599|reactome:R-MMU-6811558|reactome:R-MMU-9013404|go:"GO:0043304"(regulation of mast cell degranulation)|ensembl:ENSMUSG00000033220(gene)|ensembl:ENSMUST00000043214(transcript)|dip:DIP-41834N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:e+jv1gu9ydUEvBgplFcRQ6APjw810090 rigid:hf1RWCZZp1ql1Y79GhZeGoW79Fg false sufficient binding region:89-729|his tag:n-n - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q9Z0P5 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-8319051|uniprotkb:Q3TZG2|intact:MINT-4131249|uniprotkb:Q8BN77|uniprotkb:Q9DCK8|uniprotkb:Q3TD06|ensembl:ENSMUSP00000024047 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:twf2_mouse(display_long)|uniprotkb:Twf2(gene name)|psi-mi:Twf2(display_short)|uniprotkb:Ptk9l(gene name synonym)|uniprotkb:Twinfilin-1-like protein(gene name synonym)|uniprotkb:A6-related protein(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_036006.1|dip:DIP-61549N|ensembl:ENSMUSG00000023277(gene)|ensembl:ENSMUST00000024047(transcript)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030016"(myofibril)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032420"(stereocilium)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028458|interpro:IPR029006|mint:Q9Z0P5|rcsb pdb:7DS3 psi-mi:"MI:0465"(dip) - function:Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles|comment:mint full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:RWaTqcv6iuuBNh78sOifPKdnvKc10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P15532 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-494506|ensembl:ENSMUSP00000117022 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:ndka_mouse(display_long)|uniprotkb:Tumor metastatic process-associated protein(gene name synonym)|uniprotkb:Metastasis inhibition factor NM23(gene name synonym)|uniprotkb:NDPK-A(gene name synonym)|uniprotkb:nm23-M1(gene name synonym)|uniprotkb:Nme1(gene name)|psi-mi:Nme1(display_short)|uniprotkb:Nm23(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_032730.1|dip:DIP-34130N|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|ensembl:ENSMUSG00000037601(gene)|ensembl:ENSMUST00000135884(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007595"(lactation)|mint:P15532|reactome:R-MMU-499943|interpro:IPR036850 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:W7YjLO1L9xpbyRWWFhmcqCT3y3E10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P40124 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP, C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P24452 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-12603150 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:capg_mouse(display_long)|uniprotkb:Capg(gene name)|psi-mi:Capg(display_short)|uniprotkb:Mbh1(gene name synonym)|uniprotkb:Actin regulatory protein CAP-G(gene name synonym)|uniprotkb:Actin-capping protein GCAP39(gene name synonym)|uniprotkb:Myc basic motif homolog 1(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N go:"GO:0001726"(ruffle)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|go:"GO:0030031"(cell projection assembly)|interpro:IPR029006|interpro:IPR029917|dip:DIP-61550N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:ADL2NrbHJsHiv+UcH6ES46LMyF010090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q91YR1 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-527441|uniprotkb:Q52L77|uniprotkb:Q80X09|uniprotkb:O09132|ensembl:ENSMUSP00000023087 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:twf1_mouse(display_long)|uniprotkb:Protein A6(gene name synonym)|uniprotkb:Twf1(gene name)|psi-mi:Twf1(display_short)|uniprotkb:Ptk9(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N dip:DIP-33923N|refseq:NP_032997.3|ensembl:ENSMUSG00000022451(gene)|ensembl:ENSMUST00000023087(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043538"(regulation of actin phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR028458|interpro:IPR029006|mint:Q91YR1|rcsb pdb:1M4J|rcsb pdb:2D8B|rcsb pdb:2HD7|rcsb pdb:3DAW|rcsb pdb:6RSW|rcsb pdb:6YP9|rcsb pdb:7DS2|rcsb pdb:7DS4|rcsb pdb:7DS6|rcsb pdb:7DS8|rcsb pdb:7DSB|reactome:R-MMU-9013418 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:GgCN343v3YPfA5sIWax5s80Yjuc10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P18760 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-1183994|ensembl:ENSMUSP00000147514 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:cof1_mouse(display_long)|uniprotkb:Cfl1(gene name)|psi-mi:Cfl1(display_short)|uniprotkb:Cofilin, non-muscle isoform(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_031713.1|ensembl:ENSMUSG00000056201(gene)|ensembl:ENSMUST00000209469(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001842"(neural fold formation)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030043"(actin filament fragmentation)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030426"(growth cone)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0030836"(positive regulation of actin filament depolymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031252"(cell leading edge)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048870"(cell motility)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051511"(negative regulation of unidimensional cell growth)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090732"(cofilin-actin rod)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902936"(phosphatidylinositol bisphosphate binding)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905873"(positive regulation of protein localization to cell leading edge)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000784"(positive regulation of establishment of cell polarity regulating cell shape)|go:"GO:2000814"(positive regulation of barbed-end actin filament capping)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR017904|interpro:IPR027234|interpro:IPR029006|mint:P18760|dip:DIP-38073N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:nw/9u2+2nq9Ef43SapV43MeOtjE10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P13020 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:Q8K1I7 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70315 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-644195|ensembl:ENSMUSP00000033505 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:O08808 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-1026445|ensembl:ENSMUSP00000111297 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:diap1_mouse(display_long)|uniprotkb:Diaphanous-related formin-1(gene name synonym)|uniprotkb:p140mDIA(gene name synonym)|uniprotkb:Diaph1(gene name)|psi-mi:Diaph1(display_short)|uniprotkb:Diap1(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_031884.1|ensembl:ENSMUSG00000024456(gene)|ensembl:ENSMUST00000115634(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007420"(brain development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O08808|rcsb pdb:1Z2C|rcsb pdb:2BAP|rcsb pdb:2BNX|rcsb pdb:2F31|rcsb pdb:2V8F|rcsb pdb:3EG5|rcsb pdb:3O4X|rcsb pdb:3OBV|rcsb pdb:4UWX|reactome:R-MMU-5663220|reactome:R-MMU-6785631|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013405|reactome:R-MMU-9035034|rcsb pdb:1V9D|dip:DIP-29028N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:cSWfzfilw9WnzAOYZE3i+0x9G5c10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70460 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-990384|uniprotkb:Q3UDF1|uniprotkb:Q91VD2|uniprotkb:Q9R214|uniprotkb:Q3TAP0|uniprotkb:Q3TCD2|uniprotkb:Q3U0C2|ensembl:ENSMUSP00000032561 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:vasp_mouse(display_long)|uniprotkb:Vasp(gene name)|psi-mi:Vasp(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N ensembl:ENSMUSG00000030403(gene)|ensembl:ENSMUST00000032561(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0051289"(protein homotetramerization)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034367|interpro:IPR038023|mint:P70460|rcsb pdb:2V8C|reactome:R-MMU-376176|reactome:R-MMU-446353|refseq:NP_033525.2|refseq:NP_001268950.1|refseq:NP_001268951.1|dip:DIP-29360N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:AgIQZ6LcYTav4f8CrTLmaO9fpo410090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P70429 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-9083035|uniprotkb:Q9ERU8|ensembl:ENSMUSP00000021689 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:evl_mouse(display_long)|uniprotkb:Evl(gene name)|psi-mi:Evl(display_short)|uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_001156866.1|refseq:NP_031991.3|dip:DIP-40886N|ensembl:ENSMUSG00000021262(gene)|ensembl:ENSMUST00000021689(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030168"(platelet activation)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0045010"(actin nucleation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034319|interpro:IPR038023|rcsb pdb:1QC6|reactome:R-MMU-376176|reactome:R-MMU-5663220 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:/CnbUQjtMmlqkIf8NxYJIOicIYk10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q93KQ6 uniprotkb:P62962 intact:EBI-16142618|ensemblbacteria:CNK41725 intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437 psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:630(yeren)|taxid:630(Yersinia enterocolitica) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16142792|imex:IM-24436-7|dip:DIP-199136E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090 rigid:mmJAOyyInrXCtkaQEKYRBLa1c70 false sufficient binding region:89-729|his tag:n-n|mutation:596-596,592-592,588-588 - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0424"(protein kinase assay) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142830|imex:IM-24436-8|dip:DIP-199128E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:2hMtitSf39iKU3slJhOVaapfMzU false - sufficient binding region:89-729|mutation disrupting interaction strength:727-727,723-723,376-376,374-374 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P60709 uniprotkb:Q93KQ6 intact:EBI-353944|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q64316|uniprotkb:Q75MN2|uniprotkb:Q96B34|uniprotkb:Q96HG5|ensembl:ENSP00000494269|ensembl:ENSP00000494750|ensembl:ENSP00000495995|ensembl:ENSP00000501862|ensembl:ENSP00000502821 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:actb_human(display_long)|uniprotkb:ACTB(gene name)|psi-mi:ACTB(display_short)|uniprotkb:Beta-actin(gene name synonym) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0017"(classical fluorescence spectroscopy) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142894|imex:IM-24436-11|dip:DIP-199129E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001092.1|ensembl:ENSG00000075624(gene)|ensembl:ENST00000493945(transcript)|ensembl:ENST00000642480(transcript)|ensembl:ENST00000646664(transcript)|ensembl:ENST00000674681(transcript)|ensembl:ENST00000675515(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000785"(chromatin)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043044"|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0051623"(positive regulation of norepinephrine uptake)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070160"(tight junction)|go:"GO:0070527"(platelet aggregation)|reactome:R-HSA-4420097|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072562"(blood microparticle)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60709|rcsb pdb:3BYH|rcsb pdb:3D2U|rcsb pdb:3J82|rcsb pdb:3LUE|rcsb pdb:6ANU|rcsb pdb:6ICT|rcsb pdb:6ICV|rcsb pdb:6LTJ|rcsb pdb:6MBJ|rcsb pdb:6MBK|rcsb pdb:6MBL|rcsb pdb:6NBW|rcsb pdb:6OX0|rcsb pdb:6OX1|rcsb pdb:6OX2|rcsb pdb:6OX3|rcsb pdb:6OX4|rcsb pdb:6OX5|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|rcsb pdb:7AS4|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3214847|reactome:R-HSA-389957|reactome:R-HSA-390450|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-446353|reactome:R-HSA-5250924|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-5689603|reactome:R-HSA-5696394|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9035034|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422|reactome:R-HSA-983231|reactome:R-HSA-445095|dip:DIP-29686N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc9606 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:JnZFNCRgNWw3rx5h2i3hadBfNdY false pyrene label:?-? sufficient binding region:89-729|mutation decreasing interaction strength:245-245 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40121 uniprotkb:G3CKA6 intact:EBI-4291044|uniprotkb:D6W5K8|uniprotkb:Q53SA7|ensembl:ENSP00000263867|ensembl:ENSP00000386315|ensembl:ENSP00000386965|uniprotkb:B8ZZS7 intact:EBI-16142639 psi-mi:capg_human(display_long)|uniprotkb:CAPG(gene name)|psi-mi:CAPG(display_short)|uniprotkb:AFCP(gene name synonym)|uniprotkb:MCP(gene name synonym)|uniprotkb:Actin regulatory protein CAP-G(gene name synonym) psi-mi:g3cka6_spofr(display_long) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142874|imex:IM-24436-10|dip:DIP-199134E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001738.2|refseq:XP_011531424.1|refseq:XP_011531425.1|refseq:NP_001243068.1|ensembl:ENSG00000042493(gene)|ensembl:ENST00000263867(transcript)|ensembl:ENST00000409670(transcript)|ensembl:ENST00000409724(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR029917|mint:P40121|rcsb pdb:1J72|rcsb pdb:1JHW|refseq:NP_001307661.1|refseq:NP_001307662.1|refseq:NP_001243069.1|dip:DIP-61547N interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:QgyN9LayNHJZaKZygTug8GAs6QE9606 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rigid:TC5sCx86uJfvfTJ6Ij+h6UHJjeA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40121 uniprotkb:Q93KQ6 intact:EBI-4291044|uniprotkb:D6W5K8|uniprotkb:Q53SA7|ensembl:ENSP00000263867|ensembl:ENSP00000386315|ensembl:ENSP00000386965|uniprotkb:B8ZZS7 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:capg_human(display_long)|uniprotkb:CAPG(gene name)|psi-mi:CAPG(display_short)|uniprotkb:AFCP(gene name synonym)|uniprotkb:MCP(gene name synonym)|uniprotkb:Actin regulatory protein CAP-G(gene name synonym) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142874|imex:IM-24436-10|dip:DIP-199134E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001738.2|refseq:XP_011531424.1|refseq:XP_011531425.1|refseq:NP_001243068.1|ensembl:ENSG00000042493(gene)|ensembl:ENST00000263867(transcript)|ensembl:ENST00000409670(transcript)|ensembl:ENST00000409724(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0007417"(central nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090543"(Flemming body)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR029917|mint:P40121|rcsb pdb:1J72|rcsb pdb:1JHW|refseq:NP_001307661.1|refseq:NP_001307662.1|refseq:NP_001243069.1|dip:DIP-61547N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:QgyN9LayNHJZaKZygTug8GAs6QE9606 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:TC5sCx86uJfvfTJ6Ij+h6UHJjeA false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16142855|imex:IM-24436-9|dip:DIP-199128E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:2hMtitSf39iKU3slJhOVaapfMzU false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:P07737 intact:EBI-16142639 intact:EBI-713780|ensembl:ENSP00000225655|uniprotkb:Q53Y44 psi-mi:g3cka6_spofr(display_long) psi-mi:prof1_human(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:PFN1(gene name)|psi-mi:PFN1(display_short)|uniprotkb:Epididymis tissue protein Li 184a(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142918|imex:IM-24436-12|dip:DIP-199132E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensembl:ENSG00000108518(gene)|ensembl:ENST00000225655(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0072562"(blood microparticle)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P07737|rcsb pdb:1AWI|rcsb pdb:1CF0|rcsb pdb:1CJF|rcsb pdb:1FIK|rcsb pdb:1FIL|rcsb pdb:1PFL|rcsb pdb:2PAV|rcsb pdb:2PBD|rcsb pdb:3CHW|rcsb pdb:4X1L|rcsb pdb:4X1M|rcsb pdb:4X25|rcsb pdb:6NAS|rcsb pdb:6NBE|rcsb pdb:6NBW|reactome:R-HSA-114608|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|reactome:R-HSA-4086400|reactome:R-HSA-5663220|reactome:R-HSA-376176|refseq:NP_005013.1|dip:DIP-30N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:CncaC5RMylvzFLhqzpS+VbhQn6I9606 rigid:ZcVVf/IIi7DALmcNLzlpuPTJ3Q8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:G3CKA6 uniprotkb:Q93KQ6 intact:EBI-16142639 intact:EBI-16142618|ensemblbacteria:CNK41725 psi-mi:g3cka6_spofr(display_long) psi-mi:q93kq6_yeren(display_long)|uniprotkb:yopO(gene name)|psi-mi:yopO(display_short)|uniprotkb:ypkA(gene name synonym)|uniprotkb:ERS008652_04012(orf name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2015) pubmed:25664724|doi:10.1038/nsmb.2964|imex:IM-24436 taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)") taxid:630(yeren)|taxid:630(Yersinia enterocolitica) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16142918|imex:IM-24436-12|dip:DIP-199132E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR043129|rcsb pdb:4CI6|rcsb pdb:5CE3|go:"GO:0005524"(ATP binding)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|dip:DIP-61546N ensemblbacteria:CNK41725(transcript)|ensemblbacteria:ERS137951_04034(gene)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003547(Serine/threonine protein kinase, yersinia)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR019093|interpro:IPR043119|interpro:IPR043120|rcsb pdb:4CI6|rcsb pdb:5CE3|refseq:NP_783721.1|refseq:NP_863565.1|refseq:WP_011100759.1|dip:DIP-61545N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:+xv2lgcxf6MjWDPCRNy4aU5IYrE7108 rogid:FqNA7kyspbucA76A65b/VQNfVME630 rigid:ZcVVf/IIi7DALmcNLzlpuPTJ3Q8 false - sufficient binding region:89-729 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)