#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99257	uniprotkb:P34232	intact:EBI-11642|ensemblfungi:YPL169C|uniprotkb:D6W3J9	intact:EBI-11585|ensemblfungi:YKL186C|uniprotkb:D6VX14	psi-mi:mex67_yeast(display_long)|uniprotkb:MEX67(gene name)|psi-mi:MEX67(display_short)|uniprotkb:P2520(orf name)|uniprotkb:YPL169C(locus name)	psi-mi:mtr2_yeast(display_long)|uniprotkb:YKL186C(locus name)|uniprotkb:MTR2(gene name)|psi-mi:MTR2(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096507|wwpdb:4WWU|imex:IM-25762-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL169C(gene)|ensemblfungi:YPL169C_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|interpro:IPR032710|interpro:IPR040736|go:"GO:0015288"(porin activity)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|rcsb pdb:1OF5|rcsb pdb:2JP7|rcsb pdb:2KHH|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:4WWU|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0051168"(nuclear export)|rcsb pdb:6EXZ|go:"GO:0055085"(transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR005637(TAP, C-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR018222|interpro:IPR030217|interpro:IPR032675|refseq:NP_015156.1|sgd:S000006090|mint:Q99257|dip:DIP-3984N	go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0044613"(nuclear pore central transport channel)|interpro:IPR019488|interpro:IPR032710|rcsb pdb:1OF5|rcsb pdb:4WWU|ensemblfungi:YKL186C(gene)|ensemblfungi:YKL186C_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|refseq:NP_012735.1|sgd:S000001669|mint:P34232|dip:DIP-4856N	-	crc64:6CE55EEC6FA40B40	-	3d-resolution:3.3A|3d-r-factors:Rworking 0.228  Rfree 0.284|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/31	2017/05/31	rogid:nIu6N+mnZtRkH8psmpu1AyfB5uo559292	rogid:Ej3EjRsyjA8wdaZRIg1EQnP3uaM559292	rigid:PFdkz5YPamVu/kkl5Fq4HryxvOI	false	sufficient binding region:1-487	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99257	uniprotkb:P34232	intact:EBI-11642|ensemblfungi:YPL169C|uniprotkb:D6W3J9	intact:EBI-11585|ensemblfungi:YKL186C|uniprotkb:D6VX14	psi-mi:mex67_yeast(display_long)|uniprotkb:MEX67(gene name)|psi-mi:MEX67(display_short)|uniprotkb:P2520(orf name)|uniprotkb:YPL169C(locus name)	psi-mi:mtr2_yeast(display_long)|uniprotkb:YKL186C(locus name)|uniprotkb:MTR2(gene name)|psi-mi:MTR2(display_short)	psi-mi:"MI:0826"(x ray scattering)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096736|imex:IM-25762-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YPL169C(gene)|ensemblfungi:YPL169C_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|interpro:IPR032710|interpro:IPR040736|go:"GO:0015288"(porin activity)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|rcsb pdb:1OF5|rcsb pdb:2JP7|rcsb pdb:2KHH|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:4WWU|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0051168"(nuclear export)|rcsb pdb:6EXZ|go:"GO:0055085"(transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR005637(TAP, C-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR018222|interpro:IPR030217|interpro:IPR032675|refseq:NP_015156.1|sgd:S000006090|mint:Q99257|dip:DIP-3984N	go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0044613"(nuclear pore central transport channel)|interpro:IPR019488|interpro:IPR032710|rcsb pdb:1OF5|rcsb pdb:4WWU|ensemblfungi:YKL186C(gene)|ensemblfungi:YKL186C_mRNA(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|refseq:NP_012735.1|sgd:S000001669|mint:P34232|dip:DIP-4856N	-	crc64:6CE55EEC6FA40B40	-	figure legend:Fig 6A, 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/31	2017/06/01	rogid:nIu6N+mnZtRkH8psmpu1AyfB5uo559292	rogid:Ej3EjRsyjA8wdaZRIg1EQnP3uaM559292	rigid:PFdkz5YPamVu/kkl5Fq4HryxvOI	false	sufficient binding region:101-487	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15096752	wwpdb:4WWU	-	intact:EBI-15096767|wwpdb:1of5	psi-mi:polya_15(display_short)|psi-mi:EBI-15096752(display_long)	psi-mi:mex67-mtr2_yeast(display_short)|psi-mi:4WWU(display_long)|intact:mRNA nuclear export factor complex, MEX67-MTR2(complex recommended name)|intact:"MEX67:MTR2"(complex systematic name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096783|imex:IM-25762-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|intact:EBI-15096507(exp-evidence)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0005634"(nucleus)|complex portal:CPX-1142(complex-primary)	-	-	curated-complex:"Mediates the export of bulk mRNA through direct interactions with both the mRNA cargo and nuclear pore proteins that contain characteristic phenylalanine-glycine repeating sequence motifs (FG-nucleoporins or FG-nups). Also contributes to ribosomal subunit export."|complex-properties:The alignment of the leucine rich repeat and nuclear transport factor 2-like domains of MEX67 functions to generate an extensive positively-charged surface on the molecule that facilitates RNA binding and which positions the mRNA cargo.|complex-assembly:Heterodimer	figure legend:Figs. 7A, 7B, 7C, 7D, 8|comment:Mutations in the pre-alpha1 loop of the NTF2L domain of Mex67 reduce the binding affinity to polyA15 RNA.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.6x10^-7(molar)	2017/05/31	2017/06/01	-	-	-	false	-	sufficient binding region:1-487|sufficient binding region:101-487|sufficient binding region:264-487	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15096754	wwpdb:4WWU	-	intact:EBI-15096767|wwpdb:1of5	psi-mi:polyu_15(display_short)|psi-mi:EBI-15096754(display_long)	psi-mi:mex67-mtr2_yeast(display_short)|psi-mi:4WWU(display_long)|intact:mRNA nuclear export factor complex, MEX67-MTR2(complex recommended name)|intact:"MEX67:MTR2"(complex systematic name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096788|imex:IM-25762-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|intact:EBI-15096507(exp-evidence)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0005634"(nucleus)|complex portal:CPX-1142(complex-primary)	-	-	curated-complex:"Mediates the export of bulk mRNA through direct interactions with both the mRNA cargo and nuclear pore proteins that contain characteristic phenylalanine-glycine repeating sequence motifs (FG-nucleoporins or FG-nups). Also contributes to ribosomal subunit export."|complex-properties:The alignment of the leucine rich repeat and nuclear transport factor 2-like domains of MEX67 functions to generate an extensive positively-charged surface on the molecule that facilitates RNA binding and which positions the mRNA cargo.|complex-assembly:Heterodimer	figure legend:Fig. 7A, 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-7(molar)	2017/05/31	2017/06/01	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15096758	wwpdb:4WWU	-	intact:EBI-15096767|wwpdb:1of5	psi-mi:polyg_15(display_short)|psi-mi:EBI-15096758(display_long)	psi-mi:mex67-mtr2_yeast(display_short)|psi-mi:4WWU(display_long)|intact:mRNA nuclear export factor complex, MEX67-MTR2(complex recommended name)|intact:"MEX67:MTR2"(complex systematic name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096793|imex:IM-25762-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|intact:EBI-15096507(exp-evidence)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0005634"(nucleus)|complex portal:CPX-1142(complex-primary)	-	-	curated-complex:"Mediates the export of bulk mRNA through direct interactions with both the mRNA cargo and nuclear pore proteins that contain characteristic phenylalanine-glycine repeating sequence motifs (FG-nucleoporins or FG-nups). Also contributes to ribosomal subunit export."|complex-properties:The alignment of the leucine rich repeat and nuclear transport factor 2-like domains of MEX67 functions to generate an extensive positively-charged surface on the molecule that facilitates RNA binding and which positions the mRNA cargo.|complex-assembly:Heterodimer	figure legend:Fig. 7A, 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-7(molar)	2017/05/31	2017/06/01	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15096756	wwpdb:4WWU	-	intact:EBI-15096767|wwpdb:1of5	psi-mi:polyc_15(display_short)|psi-mi:EBI-15096756(display_long)	psi-mi:mex67-mtr2_yeast(display_short)|psi-mi:4WWU(display_long)|intact:mRNA nuclear export factor complex, MEX67-MTR2(complex recommended name)|intact:"MEX67:MTR2"(complex systematic name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Aibara et al. (2015)	imex:IM-25762|pubmed:25618852	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096798|imex:IM-25762-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:1302"(stable complex)	-	evidence ontology:"ECO:0000353"|intact:EBI-15096507(exp-evidence)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0042272"(nuclear RNA export factor complex)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0005634"(nucleus)|complex portal:CPX-1142(complex-primary)	-	-	curated-complex:"Mediates the export of bulk mRNA through direct interactions with both the mRNA cargo and nuclear pore proteins that contain characteristic phenylalanine-glycine repeating sequence motifs (FG-nucleoporins or FG-nups). Also contributes to ribosomal subunit export."|complex-properties:The alignment of the leucine rich repeat and nuclear transport factor 2-like domains of MEX67 functions to generate an extensive positively-charged surface on the molecule that facilitates RNA binding and which positions the mRNA cargo.|complex-assembly:Heterodimer	figure legend:Fig. 7A, 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.3x10^-7(molar)	2017/05/31	2017/06/01	-	-	-	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)