#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00629	uniprotkb:P31345	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-6051231	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140049|imex:IM-24202-1|dip:DIP-198727E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:kxjlV/htK3bl6iDniIilhPvLj7M	false	sufficient binding region:59-521	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52293	uniprotkb:P31345	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	intact:EBI-6051231	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140092|imex:IM-24202-3|dip:DIP-198726E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:X5LXm76Vq04W9pwhGnqk+mNqLFI	false	sufficient binding region:60-529|glutathione s tranferase tag:n-n	sufficient binding region:738-759|maltose binding protein tag:n-n|sufficient binding region:155-170	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P52293	uniprotkb:P31345	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	intact:EBI-6051231	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140071|imex:IM-24202-2|dip:DIP-198726E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:X5LXm76Vq04W9pwhGnqk+mNqLFI	false	sufficient binding region:60-529	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60684	uniprotkb:P31345	intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5	intact:EBI-6051231	psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140120|imex:IM-24202-4|dip:DIP-198728E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:m9T2L5N3f79MK7ATZxzPNaD5YIc	false	sufficient binding region:59-536	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60684	uniprotkb:P31345	intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5	intact:EBI-6051231	psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140141|imex:IM-24202-5|dip:DIP-198728E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:m9T2L5N3f79MK7ATZxzPNaD5YIc	false	sufficient binding region:59-536|glutathione s tranferase tag:n-n	sufficient binding region:738-759|sufficient binding region:155-170|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P52294	uniprotkb:P31345	intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93	intact:EBI-6051231	psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140168|imex:IM-24202-6|dip:DIP-57370E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:ykPbkM0neYan0MkzCMTGsFAKspU	false	glutathione s tranferase tag:n-n	sufficient binding region:678-759|sufficient binding region:155-170|maltose binding protein tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O60684	uniprotkb:P31345	intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5	intact:EBI-6051231	psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140235|imex:IM-24202-9|dip:DIP-198728E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:m9T2L5N3f79MK7ATZxzPNaD5YIc	false	sufficient binding region:59-536	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52293	uniprotkb:P31345	intact:EBI-3043908|ensembl:ENSMUSP00000018506|ensembl:ENSMUSP00000137310|uniprotkb:Q64292	intact:EBI-6051231	psi-mi:ima1_mouse(display_long)|uniprotkb:Kpna2(gene name)|psi-mi:Kpna2(display_short)|uniprotkb:Rch1(gene name synonym)|uniprotkb:Importin alpha P1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:Pendulin(gene name synonym)|uniprotkb:Pore targeting complex 58 kDa subunit(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140214|imex:IM-24202-8|dip:DIP-198726E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018362(gene)|ensembl:ENSMUSG00000066878(gene)|ensembl:ENSMUST00000018506(transcript)|ensembl:ENSMUST00000086423(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52293|rcsb pdb:1EJL|rcsb pdb:1EJY|rcsb pdb:1IAL|rcsb pdb:1IQ1|rcsb pdb:1PJM|rcsb pdb:1PJN|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1Y2A|rcsb pdb:2C1M|rcsb pdb:2YNR|rcsb pdb:3BTR|rcsb pdb:3KND|rcsb pdb:3L3Q|rcsb pdb:3OQS|rcsb pdb:3Q5U|rcsb pdb:3RZ9|rcsb pdb:3RZX|rcsb pdb:3TPM|rcsb pdb:3TPO|rcsb pdb:3UKW|rcsb pdb:3UKX|rcsb pdb:3UKZ|rcsb pdb:3UL0|rcsb pdb:3UL1|rcsb pdb:3UVU|rcsb pdb:3VE6|rcsb pdb:3ZIN|rcsb pdb:3ZIO|rcsb pdb:3ZIP|rcsb pdb:3ZIQ|rcsb pdb:3ZIR|rcsb pdb:4BA3|rcsb pdb:4HTV|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:4OIH|rcsb pdb:4U54|rcsb pdb:4U58|rcsb pdb:4U5L|rcsb pdb:4U5N|rcsb pdb:4U5O|rcsb pdb:4U5S|rcsb pdb:4U5U|rcsb pdb:4U5V|rcsb pdb:4UAF|rcsb pdb:4YI0|rcsb pdb:4ZDU|rcsb pdb:5B56|rcsb pdb:5CTT|rcsb pdb:5D5K|rcsb pdb:5E6Q|rcsb pdb:5EKF|rcsb pdb:5EKG|rcsb pdb:5FC8|rcsb pdb:5GXW|rcsb pdb:3UKY|rcsb pdb:5HHG|rcsb pdb:5HUW|rcsb pdb:5HUY|rcsb pdb:5K9S|rcsb pdb:5KLR|rcsb pdb:5SVZ|rcsb pdb:5U5P|rcsb pdb:5U5R|rcsb pdb:5UMZ|rcsb pdb:5V5O|rcsb pdb:5V5P|rcsb pdb:5W41|rcsb pdb:5W4E|rcsb pdb:5W4F|rcsb pdb:5W4G|rcsb pdb:5WUM|rcsb pdb:5WUN|rcsb pdb:5X8N|rcsb pdb:6BVT|rcsb pdb:6BW0|rcsb pdb:6BW1|rcsb pdb:6D7M|rcsb pdb:6D7N|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:5KLT|rcsb pdb:6IW8|rcsb pdb:6IWA|rcsb pdb:6K06|rcsb pdb:6MJL|rcsb pdb:6P6A|rcsb pdb:6P6E|rcsb pdb:6WX7|rcsb pdb:7JJM|rcsb pdb:7JK7|rcsb pdb:7JVO|rcsb pdb:7L04|reactome:R-MMU-5693548|refseq:NP_034785.1|dip:DIP-47774N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:qML5OVHqAJODiP+FSG9fTsiV3JQ10090	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:X5LXm76Vq04W9pwhGnqk+mNqLFI	false	sufficient binding region:60-529	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00629	uniprotkb:P31345	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-6051231	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140193|imex:IM-24202-7|dip:DIP-198727E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:kxjlV/htK3bl6iDniIilhPvLj7M	false	sufficient binding region:59-521	sufficient binding region:678-759	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00629	uniprotkb:P31345	intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2	intact:EBI-6051231	psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym)	psi-mi:pb2_i75a3(display_long)|uniprotkb:PB2(gene name)|psi-mi:PB2(display_short)|uniprotkb:RNA-directed RNA polymerase subunit P3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Pumroy et al. (2015)	pubmed:25599645|doi:"https://doi.org/10.1016/j.str.2014.11.015"|imex:IM-24202	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:392809(i75a3)|taxid:392809("Influenza A virus (strain A/Victoria/3/1975 H3N2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16140256|imex:IM-24202-10|dip:DIP-198727E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N	dip:DIP-29297N|go:"GO:0003723"(RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039523"(suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0075526"(cap snatching)|interpro:IPR001591(RNA polymerase, PB2 subunit, orthomyxoviridae)|interpro:IPR037258|rcsb pdb:2GMO|rcsb pdb:2JDQ|rcsb pdb:2VQZ|rcsb pdb:2VY6|rcsb pdb:2VY7|rcsb pdb:2VY8|rcsb pdb:4NCE|rcsb pdb:4NCM|rcsb pdb:4P1U|rcsb pdb:4UAD|rcsb pdb:4UAE|rcsb pdb:4UAF|rcsb pdb:6EUV|rcsb pdb:6EUY	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:/cng/xZ42E2juzHNOpuQTP+amx89606	rogid:vMHH6CyK4jxOxbv+xu+IqHVYi5A392809	rigid:kxjlV/htK3bl6iDniIilhPvLj7M	false	sufficient binding region:59-521|glutathione s tranferase tag:n-n	sufficient binding region:738-759|maltose binding protein tag:n-n|sufficient binding region:155-170	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)