#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P62812 uniprotkb:O89050 intact:EBI-770691|uniprotkb:P18504|ensembl:ENSMUSP00000020707|ensembl:ENSMUSP00000146133 intact:EBI-11017656|ensembl:ENSMUSP00000026699 psi-mi:gbra1_mouse(display_long)|uniprotkb:"GABA(A) receptor subunit alpha-1"(gene name synonym)|uniprotkb:Gabra1(gene name)|psi-mi:Gabra1(display_short)|uniprotkb:Gabra-1(gene name synonym) psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:"MI:0065"(isothermal titration calorimetry) Delto et al. (2015) pubmed:25579817|doi:10.1016/j.str.2014.11.016|imex:IM-24198 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16138569|imex:IM-24198-1|dip:DIP-198719E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034380.1|refseq:XP_006532259.1|refseq:XP_017169748.1|refseq:XP_017169749.1|dip:DIP-32219N|ensembl:ENSMUSG00000010803(gene)|ensembl:ENSMUST00000020707(transcript)|ensembl:ENSMUST00000205546(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005237"(inhibitory extracellular ligand-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0016020"(membrane)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050809"(diazepam binding)|go:"GO:0050877"(nervous system process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902710"(GABA receptor complex)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:1904862"(inhibitory synapse assembly)|interpro:IPR001390(Gamma-aminobutyric-acid A receptor, alpha subunit)|interpro:IPR005431(Gamma-aminobutyric-acid A receptor, alpha 1 subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:5OSA|rcsb pdb:5OSB|rcsb pdb:5OSC|reactome:R-MMU-977443 refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:7l4wzGez8m0Cu7ImDN+J2BKurwg10090 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rigid:edEK3JNeDR3cvnWLZzez/nEc+lQ false sufficient binding region:334-420 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O89050 uniprotkb:O89050 intact:EBI-11017656|ensembl:ENSMUSP00000026699 intact:EBI-11017656|ensembl:ENSMUSP00000026699 psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:"MI:0114"(x-ray crystallography) Delto et al. (2015) pubmed:25579817|doi:10.1016/j.str.2014.11.016|imex:IM-24198 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16138589|imex:IM-24198-2|dip:DIP-198718E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rigid:rru6UkOz6YLwMVAf3LgO4pnZtY4 false sufficient binding region:12-205 sufficient binding region:12-205 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O89050 uniprotkb:O89050 intact:EBI-11017656|ensembl:ENSMUSP00000026699 intact:EBI-11017656|ensembl:ENSMUSP00000026699 psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:"MI:0030"(cross-linking study) Delto et al. (2015) pubmed:25579817|doi:10.1016/j.str.2014.11.016|imex:IM-24198 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16138607|imex:IM-24198-3|dip:DIP-198718E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rigid:rru6UkOz6YLwMVAf3LgO4pnZtY4 false sufficient binding region:1-205|sufficient binding region:157-735 sufficient binding region:1-205|sufficient binding region:157-735 - 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O89050 uniprotkb:O89050 intact:EBI-11017656|ensembl:ENSMUSP00000026699 intact:EBI-11017656|ensembl:ENSMUSP00000026699 psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:"MI:0067"(light scattering) Delto et al. (2015) pubmed:25579817|doi:10.1016/j.str.2014.11.016|imex:IM-24198 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16138627|imex:IM-24198-4|dip:DIP-198718E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rigid:rru6UkOz6YLwMVAf3LgO4pnZtY4 false sufficient binding region:1-205|sufficient binding region:157-735|mutation decreasing interaction strength:196-196,184-184|mutation decreasing interaction strength:183-183,182-182|necessary binding region:626-735|mutation disrupting interaction strength:196-196,184-184,144-144|mutation decreasing interaction strength:144-144 sufficient binding region:1-205|sufficient binding region:157-735|mutation decreasing interaction strength:196-196,184-184|mutation decreasing interaction strength:183-183,182-182|necessary binding region:626-735|mutation disrupting interaction strength:196-196,184-184,144-144|mutation decreasing interaction strength:144-144 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O89050 uniprotkb:O89050 intact:EBI-11017656|ensembl:ENSMUSP00000026699 intact:EBI-11017656|ensembl:ENSMUSP00000026699 psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:mkln1_mouse(display_long)|uniprotkb:Mkln1(gene name)|psi-mi:Mkln1(display_short) psi-mi:"MI:0071"(molecular sieving) Delto et al. (2015) pubmed:25579817|doi:10.1016/j.str.2014.11.016|imex:IM-24198 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16138665|imex:IM-24198-5|dip:DIP-198718E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N refseq:NP_038819.1|ensembl:ENSMUSG00000025609(gene)|ensembl:ENSMUST00000026699(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:4PQQ|dip:DIP-61380N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rogid:WcnTf3ZwW1/+dXqESVH/kKB4yns10090 rigid:rru6UkOz6YLwMVAf3LgO4pnZtY4 false sufficient binding region:1-205|sufficient binding region:157-735|mutation decreasing interaction strength:196-196,184-184|mutation decreasing interaction strength:183-183,182-182|necessary binding region:626-735|mutation disrupting interaction strength:196-196,184-184,144-144|mutation decreasing interaction strength:144-144 sufficient binding region:1-205|sufficient binding region:157-735|mutation decreasing interaction strength:196-196,184-184|mutation decreasing interaction strength:183-183,182-182|necessary binding region:626-735|mutation disrupting interaction strength:196-196,184-184,144-144|mutation decreasing interaction strength:144-144 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)