#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P88970 uniprotkb:Q14257 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q9NVI7 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q9HCN8 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q99470 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:B1PKZ2 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-5327925|uniprotkb:O19673|uniprotkb:O19695|uniprotkb:O19794|uniprotkb:O19795|uniprotkb:O43907|uniprotkb:O77938|uniprotkb:O98010|uniprotkb:P10315|uniprotkb:P79505|uniprotkb:Q9MYA5|uniprotkb:Q9MYC4|uniprotkb:Q9TQG7|uniprotkb:Q9TQN5|uniprotkb:Q9UIN2 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:1a68_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Aw-68(gene name synonym)|uniprotkb:HLA class I histocompatibility antigen, A-28 alpha chain(gene name synonym)|uniprotkb:MHC class I antigen A*68(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 rcsb pdb:4HWZ|rcsb pdb:4HX1|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005615"(extracellular space)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009986"(cell surface)|go:"GO:0030881"(beta-2-microglobulin binding)|rcsb pdb:6EI2|uniprotkb:P01891(see-also)|go:"GO:0042612"(MHC class I protein complex)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|rcsb pdb:1HSB|rcsb pdb:1TMC|rcsb pdb:2HLA|ensembl:ENST00000457879|rcsb pdb:4I48|go:"GO:0042605"(peptide antigen binding)|ensembl:ENSG00000235657|ensembl:ENSP00000403575|go:"GO:0000139"(Golgi membrane)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0005886"(plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR036179|interpro:IPR037055|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0006955"(immune response)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib) - - no-uniprot-update: figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:r6UnYO31dZgh/h+E2JiAhAmKj2Y9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q9UBS4 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q99623 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:Q15293 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88970 uniprotkb:P27797 intact:EBI-14032409|uniprotkb:O10382|uniprotkb:Q80ID7 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:p88970_hhv8(display_long)|uniprotkb:K1(gene name)|psi-mi:K1(display_short) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032407|imex:IM-26114-141 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR021022|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR004121(Human herpesvirus K1 glycoprotein, C-terminal)|interpro:IPR036179 refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/04/17 rogid:X6dTthGXXsxg6dETNoeaWttYNGU37296 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 rigid:rNNqisBUbTS6BF82+doPw9FfI1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P54132 intact:EBI-14061656 intact:EBI-621372|ensembl:ENSP00000347232|ensembl:ENSP00000506117|uniprotkb:Q52M96 psi-mi:o40939_hhv8(display_long) psi-mi:blm_human(display_long)|uniprotkb:RecQ protein-like 3(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 2(gene name synonym)|uniprotkb:BLM(gene name)|psi-mi:BLM(display_short)|uniprotkb:RECQ2(gene name synonym)|uniprotkb:RECQL3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|ensembl:ENST00000355112(transcript)|go:"GO:0003697"(single-stranded DNA binding)|ensembl:ENST00000680772(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0004386"(helicase activity)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0016363"(nuclear matrix)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0016605"(PML body)|go:"GO:0031297"(replication fork processing)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000800"(lateral element)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0061749"(forked DNA-dependent helicase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0090329"(regulation of DNA-dependent DNA replication)|go:"GO:0090656"(t-circle formation)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|go:"GO:0048478"(replication fork protection)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012532(BDHCT)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR032284|interpro:IPR032437|interpro:IPR032439|go:"GO:0051259"(protein complex oligomerization)|interpro:IPR036388|mint:P54132|rcsb pdb:2KV2|rcsb pdb:2MH9|rcsb pdb:2RRD|rcsb pdb:3WE2|rcsb pdb:3WE3|rcsb pdb:4CDG|rcsb pdb:4CGZ|rcsb pdb:4O3M|rcsb pdb:5LUP|rcsb pdb:5MK5|rcsb pdb:5U6K|rcsb pdb:7AUC|rcsb pdb:7AUD|reactome:R-HSA-174414|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR036390|ensembl:ENSG00000197299(gene)|refseq:NP_000048.1|refseq:NP_001274175.1|refseq:NP_001274176.1|refseq:NP_001274177.1|dip:DIP-33322N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:FQ+HJ2RwfvP7EwtDzFX7ESe/qEA9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q96DI7 intact:EBI-14061656 intact:EBI-538492|uniprotkb:O75938|uniprotkb:O95320|uniprotkb:B4DQJ1|ensembl:ENSP00000263694 psi-mi:o40939_hhv8(display_long) psi-mi:snr40_human(display_long)|uniprotkb:Prp8-binding protein(gene name synonym)|uniprotkb:U5 snRNP-specific 40 kDa protein(gene name synonym)|uniprotkb:38 kDa-splicing factor(gene name synonym)|uniprotkb:SNRNP40(gene name)|psi-mi:SNRNP40(display_short)|uniprotkb:PRP8BP(gene name synonym)|uniprotkb:SFP38(gene name synonym)|uniprotkb:WDR57(gene name synonym)|uniprotkb:WD repeat-containing protein 57(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_004805.2|ensembl:ENSG00000060688(gene)|ensembl:ENST00000263694(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q96DI7|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:AfLoHYSy0MlW+OqHyEULLcpwQhQ9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9BYC8 intact:EBI-14061656 intact:EBI-7825220|ensembl:ENSP00000223324|intact:MINT-6781284|uniprotkb:Q9P098|uniprotkb:Q96Q68 psi-mi:o40939_hhv8(display_long) psi-mi:rm32_human(display_long)|uniprotkb:Mitochondrial large ribosomal subunit protein bL32m(gene name synonym)|uniprotkb:HSPC283(orf name)|uniprotkb:MRPL32(gene name)|psi-mi:MRPL32(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000106591(gene)|ensembl:ENST00000223324(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR002677(Ribosomal protein L32p)|interpro:IPR011332(Ribosomal protein, zinc-binding)|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|refseq:NP_114109.1 - - comment:mint figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:Aep9jfRYJRd0huAmQeGO4pbd6eM9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9NVS2 intact:EBI-14061656 intact:EBI-7825353|ensembl:ENSP00000361206|intact:MINT-3075179|uniprotkb:Q5QPA4|uniprotkb:A6XND3 psi-mi:o40939_hhv8(display_long) psi-mi:rt18a_human(display_long)|uniprotkb:39S ribosomal protein S18-3, mitochondrial(gene name synonym)|uniprotkb:MRPS18A(gene name)|psi-mi:MRPS18A(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bS18a(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL66(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000096080(gene)|ensembl:ENST00000372133(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR001648(Ribosomal protein S18)|interpro:IPR036870|mint:Q9NVS2|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5389840|reactome:R-HSA-5419276|reactome:R-HSA-5368286|refseq:NP_001180272.1|refseq:NP_060605.1|refseq:XP_006715197.1 - - comment:mint figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:Qv26CehXGHVNy1T9ZFZGRLY65e89606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q96DE5 intact:EBI-14061656 intact:EBI-2555937|ensembl:ENSP00000299381|ensembl:ENSP00000477760 psi-mi:o40939_hhv8(display_long) psi-mi:apc16_human(display_long)|uniprotkb:C10orf104(gene name synonym)|uniprotkb:Cyclosome subunit 16(gene name synonym)|uniprotkb:ANAPC16(gene name)|psi-mi:ANAPC16(display_short)|uniprotkb:CENP-27(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001229475.1|refseq:NP_001229476.1|refseq:NP_775744.1|ensembl:ENSG00000166295(gene)|ensembl:ENST00000299381(transcript)|ensembl:ENST00000621663(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0051301"(cell division)|interpro:IPR029641|mint:Q96DE5|rcsb pdb:4RG6|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|dip:DIP-56449N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:THae4cAe47vuWr79Lo0BoGbQY/I9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q02952 intact:EBI-14061656 intact:EBI-2562430|intact:EBI-2680946|uniprotkb:O00310|uniprotkb:O00498|uniprotkb:Q4LE68|uniprotkb:Q5SZ80|uniprotkb:Q5TGN1|uniprotkb:Q68D82|uniprotkb:Q99970|ensembl:ENSP00000253332|ensembl:ENSP00000384537 psi-mi:o40939_hhv8(display_long) psi-mi:aka12_human(display_long)|uniprotkb:AKAP12(gene name)|psi-mi:AKAP12(display_short)|uniprotkb:AKAP250(gene name synonym)|uniprotkb:A-kinase anchor protein 250 kDa(gene name synonym)|uniprotkb:Gravin(gene name synonym)|uniprotkb:Myasthenia gravis autoantigen(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_005091.2|refseq:NP_653080.1|ensembl:ENSG00000131016(gene)|ensembl:ENST00000253332(transcript)|ensembl:ENST00000402676(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090036"(regulation of protein kinase C signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1900143"(positive regulation of oligodendrocyte apoptotic process)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR018459|interpro:IPR028540|mint:Q02952|reactome:R-HSA-9013405|reactome:R-HSA-9035034|refseq:XP_005267292.1|refseq:XP_016867006.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:vx4mziqb4PDChwfwSzb7mPrCn4w9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9UJX4 intact:EBI-14061656 intact:EBI-395994|uniprotkb:Q8N4H7|uniprotkb:Q9BQD4|uniprotkb:E9PFB2|ensembl:ENSP00000261819 psi-mi:o40939_hhv8(display_long) psi-mi:apc5_human(display_long)|uniprotkb:ANAPC5(gene name)|psi-mi:ANAPC5(display_short)|uniprotkb:APC5(gene name synonym)|uniprotkb:Cyclosome subunit 5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_057321.2|refseq:NP_001131031.1|refseq:NP_001317418.1|dip:DIP-32945N|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENSG00000089053(gene)|ensembl:ENST00000261819(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR026000|interpro:IPR037679|mint:Q9UJX4|rcsb pdb:4UI9|rcsb pdb:5A31 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:Bg/ZL1IEXYdO6XblNQvxjhVX9tI9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q13042 intact:EBI-14061656 intact:EBI-994830|uniprotkb:Q96AE6|uniprotkb:Q9Y564|uniprotkb:A2A365|uniprotkb:Q5T8C8|ensembl:ENSP00000348554|ensembl:ENSP00000353549|uniprotkb:Q7Z651 psi-mi:o40939_hhv8(display_long) psi-mi:cdc16_human(display_long)|uniprotkb:ANAPC6(gene name synonym)|uniprotkb:CDC16 homolog(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 6(gene name synonym)|uniprotkb:Cyclosome subunit 6(gene name synonym)|uniprotkb:CDC16(gene name)|psi-mi:CDC16(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001072113.1|refseq:NP_003894.3|reactome:R-HSA-2559582|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|rcsb pdb:5L9T|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|rcsb pdb:5L9U|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5LCW|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR011990(Tetratricopeptide-like helical)|rcsb pdb:6Q6G|interpro:IPR019734|rcsb pdb:3HYM|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:4UI9|rcsb pdb:6TNT|reactome:R-HSA-141430|rcsb pdb:5A31|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|reactome:R-HSA-69017|reactome:R-HSA-2467813|reactome:R-HSA-179409|ensembl:ENSG00000130177(gene)|ensembl:ENST00000356221(transcript)|ensembl:ENST00000360383(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|refseq:NP_001305446.1|refseq:NP_001305447.1|refseq:NP_001317030.1|refseq:NP_001317033.1|refseq:NP_001317034.1|refseq:XP_016876322.1|dip:DIP-36423N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:AAG0s18JHrn+M5dG7T/N6t0Y97w9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q12873 intact:EBI-14061656 intact:EBI-523590|uniprotkb:Q9Y4I0|intact:EBI-28978117|ensembl:ENSP00000332628|uniprotkb:D3DTQ9|uniprotkb:E9PG89 psi-mi:o40939_hhv8(display_long) psi-mi:chd3_human(display_long)|uniprotkb:ATP-dependent helicase CHD3(gene name synonym)|uniprotkb:Mi-2 autoantigen 240 kDa protein(gene name synonym)|uniprotkb:Mi2-alpha(gene name synonym)|uniprotkb:Zinc finger helicase(gene name synonym)|uniprotkb:CHD3(gene name)|psi-mi:CHD3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - interpro:IPR023780|interpro:IPR027417|interpro:IPR036910|interpro:IPR038718|mint:Q12873|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-4551638|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191|ensembl:ENSG00000170004(gene)|ensembl:ENST00000330494(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007051"(spindle organization)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016581"(NuRD complex)|go:"GO:0016605"(PML body)|go:"GO:0034451"(centriolar satellite)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0043044"|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|go:"GO:0070615"|interpro:IPR019787|interpro:IPR023779|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|ensembl:ENSP00000332628|ensembl:ENST00000358181|ensembl:ENSP00000350907|ensembl:ENST00000380358|ensembl:ENSP00000369716|refseq:NP_001005271.2|refseq:NP_001005273.1|refseq:NP_005843.2|dip:DIP-32496N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:UjefFUXiV28qhOP9BoIUansxl+k9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q12874 intact:EBI-14061656 intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110 psi-mi:o40939_hhv8(display_long) psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:fNjNguUOXqApr46rOAEpTs2geqY9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q92558 intact:EBI-14061656 intact:EBI-1548747|uniprotkb:E1P5F2|uniprotkb:Q5SZK7|ensembl:ENSP00000352425|ensembl:ENSP00000376365|ensembl:ENSP00000376366|ensembl:ENSP00000376367|ensembl:ENSP00000376368 psi-mi:o40939_hhv8(display_long) psi-mi:wasf1_human(display_long)|uniprotkb:WASF1(gene name)|psi-mi:WASF1(display_short)|uniprotkb:KIAA0269(gene name synonym)|uniprotkb:SCAR1(gene name synonym)|uniprotkb:WAVE1(gene name synonym)|uniprotkb:Protein WAVE-1(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001020105.1|refseq:NP_001020106.1|refseq:NP_001020107.1|refseq:NP_003922.1|refseq:XP_011534535.1|refseq:XP_011534536.1|refseq:XP_016866926.1|refseq:XP_016866927.1|refseq:XP_005267260.1|refseq:XP_005267262.1|refseq:XP_005267263.1|refseq:XP_005267264.1|dip:DIP-39391N|reactome:R-HSA-9013423|reactome:R-HSA-9664422|ensembl:ENSG00000112290(gene)|ensembl:ENST00000359451(transcript)|ensembl:ENST00000392586(transcript)|ensembl:ENST00000392587(transcript)|ensembl:ENST00000392588(transcript)|ensembl:ENST00000392589(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0097484"(dendrite extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098939"(dendritic transport of mitochondrion)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q92558|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:kDHL44b54o8tE3+OR+M2CC6zi/k9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P07478 intact:EBI-14061656 intact:EBI-14061700|ensembl:ENSP00000487952|ensembl:ENSP00000488338 psi-mi:o40939_hhv8(display_long) psi-mi:try2_human(display_long)|uniprotkb:PRSS2(gene name)|psi-mi:PRSS2(display_short)|uniprotkb:TRY2(gene name synonym)|uniprotkb:TRYP2(gene name synonym)|uniprotkb:Anionic trypsinogen(gene name synonym)|uniprotkb:Serine protease 2(gene name synonym)|uniprotkb:Trypsin II(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - go:"GO:0007586"(digestion)|go:"GO:0008236"(serine-type peptidase activity)|ensembl:ENSG00000275896(gene)|ensembl:ENSG00000282049(gene)|ensembl:ENST00000539842(transcript)|ensembl:ENST00000632112(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P07478|reactome:R-HSA-1442490|reactome:R-HSA-1462054|reactome:R-HSA-1592389|reactome:R-HSA-6798695|reactome:R-HSA-6803157|refseq:NP_002761.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:xP8rgMfzospYU202s9zSfkgHHzM9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9UDY2 intact:EBI-14061656 intact:EBI-1042602|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1|intact:EBI-10989219|ensembl:ENSP00000366453|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886 psi-mi:o40939_hhv8(display_long) psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001163886.1|refseq:NP_001163887.1|refseq:NP_004808.2|refseq:XP_011517508.1|refseq:XP_011517509.1|refseq:XP_011517510.1|refseq:XP_011517511.1|ensembl:ENSG00000119139(gene)|ensembl:ENST00000377245(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035598|interpro:IPR036028|interpro:IPR036034|mint:Q9UDY2|rcsb pdb:2OSG|rcsb pdb:3E17|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:iN/EF8QWKtekoj5eON764eKAdpg9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P46063 intact:EBI-14061656 intact:EBI-2823728|uniprotkb:A8K6G2|ensembl:ENSP00000395449|ensembl:ENSP00000416739 psi-mi:o40939_hhv8(display_long) psi-mi:recq1_human(display_long)|uniprotkb:RECQL(gene name)|psi-mi:RECQL(display_short)|uniprotkb:RECQ1(gene name synonym)|uniprotkb:RECQL1(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 1(gene name synonym)|uniprotkb:DNA-dependent ATPase Q1(gene name synonym)|uniprotkb:RecQ protein-like 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_002898.2|refseq:NP_116559.1|ensembl:ENSG00000004700(gene)|ensembl:ENST00000421138(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|mint:P46063|rcsb pdb:2V1X|rcsb pdb:2WWY|rcsb pdb:4U7D|rcsb pdb:6JTZ|ensembl:ENST00000444129(transcript)|refseq:XP_005253518.1|refseq:XP_005253519.1|refseq:XP_005253520.1|refseq:XP_005253521.1|dip:DIP-29216N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:zJXPLIWtbjvhAhWH0HN+qdkCCOg9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9BQ48 intact:EBI-14061656 intact:EBI-11158976|ensembl:ENSP00000252602|ensembl:ENSP00000469581|ensembl:ENSP00000471820 psi-mi:o40939_hhv8(display_long) psi-mi:rm34_human(display_long)|uniprotkb:MRPL34(gene name)|psi-mi:MRPL34(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein bL34m(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_076426.1|refseq:XP_011526491.1|ensembl:ENSG00000130312(gene)|ensembl:ENST00000252602(transcript)|ensembl:ENST00000594999(transcript)|ensembl:ENST00000600434(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR000271(Ribosomal protein L34)|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF2|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:n5D2hwAW3JAag8Io9FoH+HYZq4g9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:O95478 intact:EBI-14061656 intact:EBI-2852366|ensembl:ENSP00000483484 psi-mi:o40939_hhv8(display_long) psi-mi:nsa2_human(display_long)|uniprotkb:NSA2(gene name)|psi-mi:NSA2(display_short)|uniprotkb:TINP1(gene name synonym)|uniprotkb:Hairy cell leukemia protein 1(gene name synonym)|uniprotkb:TGF-beta-inducible nuclear protein 1(gene name synonym)|uniprotkb:HUSSY-29(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_055701.1|refseq:NP_001258594.1|ensembl:ENSG00000164346(gene)|ensembl:ENST00000610426(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR022309|interpro:IPR039411|mint:O95478 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:UHmCVn1q0LfipKMzSFQUzmVULD49606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q7L7X3 intact:EBI-14061656 intact:EBI-1384314|uniprotkb:Q96L75|uniprotkb:Q9H2K7|uniprotkb:Q9H7S5|uniprotkb:Q9P2I6|uniprotkb:A2RUT8|uniprotkb:B7ZLV6|ensembl:ENSP00000261716 psi-mi:o40939_hhv8(display_long) psi-mi:taok1_human(display_long)|uniprotkb:Prostate-derived sterile 20-like kinase 2(gene name synonym)|uniprotkb:Thousand and one amino acid protein kinase 1(gene name synonym)|uniprotkb:TAOK1(gene name)|psi-mi:TAOK1(display_short)|uniprotkb:KIAA1361(gene name synonym)|uniprotkb:MAP3K16(gene name synonym)|uniprotkb:MARKK(gene name synonym)|uniprotkb:MARK Kinase(gene name synonym)|uniprotkb:Kinase from chicken homolog B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:XP_011523362.1|refseq:NP_065842.1|refseq:NP_079418.1|dip:DIP-39709N|ensembl:ENSG00000160551(gene)|ensembl:ENST00000261716(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:tfE56A9/KSEBu1lgTyvfrGC9kn89606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q30KQ2 intact:EBI-14061656 intact:EBI-14061677 psi-mi:o40939_hhv8(display_long) psi-mi:db130_human(display_long)|uniprotkb:DEFB130(gene name)|psi-mi:DEFB130(display_short)|uniprotkb:DEFB30(gene name synonym)|uniprotkb:DEFB130L(gene name)|psi-mi:DEFB130L(display_short)|uniprotkb:Beta-defensin 30(gene name synonym)|uniprotkb:Defensin, beta 130(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001032893.1|refseq:NP_001182186.1|ensembl:ENST00000400079|ensembl:ENSP00000382951|ensembl:ENSG00000232948|reactome:R-HSA-1461957|reactome:R-HSA-1461973|go:"GO:0005576"(extracellular region)|go:"GO:0042742"(defense response to bacterium)|interpro:IPR001855(Beta defensin) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:bjNXAFgqCmVmpCT8Ft4QlBeIsoE9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P58107 intact:EBI-14061656 intact:EBI-297954|uniprotkb:Q76E58|ensembl:ENSP00000484472|uniprotkb:A0A087X1U6|uniprotkb:Q9NSU9 psi-mi:o40939_hhv8(display_long) psi-mi:epipl_human(display_long)|uniprotkb:EPPK1(gene name)|psi-mi:EPPK1(display_short)|uniprotkb:EPIPL(gene name synonym)|uniprotkb:450 kDa epidermal antigen(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000484472|ensembl:ENSG00000261150(gene)|ensembl:ENST00000615648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042995"(cell projection)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0071944"(cell periphery)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1905041"(regulation of epithelium regeneration)|go:"GO:1990254"(keratin filament binding)|interpro:IPR001101(Plectin repeat)|interpro:IPR035915|interpro:IPR043197|refseq:NP_112598.3|refseq:XP_016869379.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:5ThrRQj4JeRG4xjZxMgueWUrjuA9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P52756 intact:EBI-14061656 intact:EBI-714003|uniprotkb:Q93021|uniprotkb:Q9BU14|uniprotkb:Q9UKY8|uniprotkb:Q9UL24|ensembl:ENSP00000343054|uniprotkb:B2RA45|uniprotkb:B4DM16|uniprotkb:B4DMF9|uniprotkb:B4DZ63|uniprotkb:Q9HDA6|intact:EBI-16431417 psi-mi:o40939_hhv8(display_long) psi-mi:rbm5_human(display_long)|uniprotkb:RNA-binding motif protein 5(gene name synonym)|uniprotkb:Putative tumor suppressor LUCA15(gene name synonym)|uniprotkb:Protein G15(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-9(gene name synonym)|uniprotkb:RBM5(gene name)|psi-mi:RBM5(display_short)|uniprotkb:H37(orf name)|uniprotkb:LUCA15(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000003756(gene)|ensembl:ENST00000347869(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR033094|interpro:IPR034991|interpro:IPR034993|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036443|interpro:IPR041591|mint:P52756|rcsb pdb:2LK0|rcsb pdb:2LK1|rcsb pdb:2LKZ|rcsb pdb:5MF9|rcsb pdb:5MFY|reactome:R-HSA-72163|refseq:NP_005769.1|refseq:XP_016860992.1|dip:DIP-47277N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:LsPTpaKrGY2xtpYofHbFVXjSi/A9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q7Z478 intact:EBI-14061656 intact:EBI-719925|uniprotkb:O75549|uniprotkb:Q63HN0|uniprotkb:Q63HN3|uniprotkb:Q8IWW2|uniprotkb:Q8N3A1|uniprotkb:Q9UMH2|intact:EBI-28967230|ensembl:ENSP00000251636 psi-mi:o40939_hhv8(display_long) psi-mi:dhx29_human(display_long)|uniprotkb:DEAH box protein 29(gene name synonym)|uniprotkb:Nucleic acid helicase DDXx(gene name synonym)|uniprotkb:DHX29(gene name)|psi-mi:DHX29(display_short)|uniprotkb:DDX29(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000251636|refseq:NP_061903.2|ensembl:ENSG00000067248(gene)|ensembl:ENST00000251636(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008494"(translation activator activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR034730|refseq:NP_001332893.1|refseq:NP_001332894.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:T78lwkAmdyEefThCR1zDrVbTBYE9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9H8Y5 intact:EBI-14061656 intact:EBI-724848|uniprotkb:Q9NVZ4|intact:EBI-28979360|ensembl:ENSP00000321617|ensembl:ENSP00000386337 psi-mi:o40939_hhv8(display_long) psi-mi:ankz1_human(display_long)|uniprotkb:Zinc finger protein 744(gene name synonym)|uniprotkb:ANKZF1(gene name)|psi-mi:ANKZF1(display_short)|uniprotkb:ZNF744(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001035869.1|refseq:NP_060559.2|ensembl:ENSP00000321617|ensembl:ENSP00000386337|ensembl:ENSG00000163516(gene)|ensembl:ENST00000323348(transcript)|ensembl:ENST00000410034(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR002110(Ankyrin)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036770|interpro:IPR041175|interpro:IPR041540 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:ddIMBu8TTSoqw3EFEPgqx+F0BHA9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:A6NFI3 intact:EBI-14061656 intact:EBI-8837065|ensembl:ENSP00000477706 psi-mi:o40939_hhv8(display_long) psi-mi:zn316_human(display_long)|uniprotkb:ZNF316(gene name)|psi-mi:ZNF316(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001265488.1|refseq:XP_006715693.1|ensembl:ENSG00000205903(gene)|ensembl:ENST00000382252(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:30kkVY+rcogc0MwvKpOQ5TWC1X89606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9UPY6 intact:EBI-14061656 intact:EBI-3907133|uniprotkb:Q86VQ2|uniprotkb:O94974|intact:EBI-28988154|ensembl:ENSP00000335055 psi-mi:o40939_hhv8(display_long) psi-mi:wasf3_human(display_long)|uniprotkb:WASF3(gene name)|psi-mi:WASF3(display_short)|uniprotkb:KIAA0900(gene name synonym)|uniprotkb:SCAR3(gene name synonym)|uniprotkb:WAVE3(gene name synonym)|uniprotkb:Protein WAVE-3(gene name synonym)|uniprotkb:Verprolin homology domain-containing protein 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9664422|reactome:R-HSA-4420097|refseq:NP_001278894.1|refseq:XP_011533191.1|refseq:XP_011533192.1|refseq:NP_006637.2|ensembl:ENSP00000335055|ensembl:ENST00000361042|ensembl:ENSP00000354325|ensembl:ENSG00000132970(gene)|ensembl:ENST00000335327(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|reactome:R-HSA-2029482|dip:DIP-61425N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:k0Dx3KqlfsrKQy4snCmKLpONVTM9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9UM13 intact:EBI-14061656 intact:EBI-1266437|uniprotkb:Q2V500|uniprotkb:Q9UG51|uniprotkb:Q9Y5R0|uniprotkb:D3DNZ7|ensembl:ENSP00000310071|ensembl:ENSP00000403891|ensembl:ENSP00000423995|ensembl:ENSP00000478501 psi-mi:o40939_hhv8(display_long) psi-mi:apc10_human(display_long)|uniprotkb:ANAPC10(gene name)|psi-mi:ANAPC10(display_short)|uniprotkb:APC10(gene name synonym)|uniprotkb:Cyclosome subunit 10(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_055700.2|refseq:NP_001305296.1|refseq:NP_001243635.1|refseq:NP_001243636.1|refseq:NP_001243637.1|refseq:NP_001243638.1|refseq:NP_001243639.1|refseq:XP_011529826.1|dip:DIP-39885N|ensembl:ENSG00000164162(gene)|ensembl:ENST00000309439(transcript)|ensembl:ENST00000451299(transcript)|ensembl:ENST00000507656(transcript)|ensembl:ENST00000613466(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR016901(Anaphase-promoting complex, subunit 10, subgroup)|mint:Q9UM13|rcsb pdb:1JHJ|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|rcsb pdb:6TLJ - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:kKLo92DrTuOsaeowcNSWKe7xyn49606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9UJ70 intact:EBI-14061656 intact:EBI-372578|uniprotkb:Q53HD5|uniprotkb:Q6IA84|uniprotkb:Q9BVP0|uniprotkb:Q9NV37|uniprotkb:Q9BS29|uniprotkb:B4DLZ5|ensembl:ENSP00000244204 psi-mi:o40939_hhv8(display_long) psi-mi:nagk_human(display_long)|uniprotkb:GlcNAc kinase(gene name synonym)|uniprotkb:NAGK(gene name)|psi-mi:NAGK(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_060037.3|ensembl:ENSG00000124357(gene)|ensembl:ENST00000244204(transcript)|interpro:IPR043129|mint:Q9UJ70|rcsb pdb:2CH5|rcsb pdb:2CH6|reactome:R-HSA-446210|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006051"(N-acetylmannosamine metabolic process)|go:"GO:0019262"(N-acetylneuraminate catabolic process)|go:"GO:0045127"(N-acetylglucosamine kinase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002731(ATPase, BadF/BadG/BcrA/BcrD type)|interpro:IPR039758 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:ao/nyOFgPuF6H39ubvyWeOQv7sM9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q9H2K8 intact:EBI-14061656 intact:EBI-1384100|uniprotkb:Q9NZM9|uniprotkb:Q9UHG7|uniprotkb:Q9HC79|uniprotkb:Q658N1|uniprotkb:Q8IUM4|ensembl:ENSP00000376317|ensembl:ENSP00000416374 psi-mi:o40939_hhv8(display_long) psi-mi:taok3_human(display_long)|uniprotkb:DPK(gene name synonym)|uniprotkb:JIK(gene name synonym)|uniprotkb:KDS(gene name synonym)|uniprotkb:MAP3K18(gene name synonym)|uniprotkb:Thousand and one amino acid protein 3(gene name synonym)|uniprotkb:Jun kinase-inhibitory kinase(gene name synonym)|uniprotkb:JNK/SAPK-inhibitory kinase(gene name synonym)|uniprotkb:Dendritic cell-derived protein kinase(gene name synonym)|uniprotkb:Cutaneous T-cell lymphoma-associated antigen HD-CL-09(gene name synonym)|uniprotkb:Kinase from chicken homolog A(gene name synonym)|uniprotkb:TAOK3(gene name)|psi-mi:TAOK3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_057365.3|ensembl:ENSP00000376317|ensembl:ENSP00000416374|refseq:NP_001333417.1|refseq:NP_001333418.1|ensembl:ENSG00000135090(gene)|ensembl:ENST00000392533(transcript)|ensembl:ENST00000419821(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0016740"(transferase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6BDN|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:hiCQiP9wMhmpZs8JOcOtP+1w2iE9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q8IX15 intact:EBI-14061656 intact:EBI-10742083|uniprotkb:A1L445|uniprotkb:B4DZ80|uniprotkb:F8WCA3|uniprotkb:Q6P049|uniprotkb:Q86XB6|uniprotkb:Q9P2A5|ensembl:ENSP00000350049 psi-mi:o40939_hhv8(display_long) psi-mi:homez_human(display_long)|uniprotkb:HOMEZ(gene name)|psi-mi:HOMEZ(display_short)|uniprotkb:Homeodomain leucine zipper-containing factor(gene name synonym)|uniprotkb:KIAA1443(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSP00000350049|ensembl:ENST00000561013|ensembl:ENSP00000453979|refseq:NP_065885.2|ensembl:ENSG00000215271(gene)|ensembl:ENST00000357460(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR001356(Homeobox)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR024578|mint:Q8IX15|rcsb pdb:2ECC|rcsb pdb:2YS9 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:t/jhjPnrNTxtpwGbiBblgwul0209606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q6GYQ0 intact:EBI-14061656 intact:EBI-3957100|uniprotkb:A6NMA4|uniprotkb:C5NU19|uniprotkb:O94960|uniprotkb:Q6GYP9|uniprotkb:Q6ZT23|uniprotkb:Q86YF3|uniprotkb:Q86YF5|uniprotkb:Q8ND69|uniprotkb:B9EK38|ensembl:ENSP00000374348 psi-mi:o40939_hhv8(display_long) psi-mi:rgpa1_human(display_long)|uniprotkb:RALGAPA1(gene name)|psi-mi:RALGAPA1(display_short)|uniprotkb:GARNL1(gene name synonym)|uniprotkb:KIAA0884(gene name synonym)|uniprotkb:TULIP1(gene name synonym)|uniprotkb:GAP-related-interacting partner to E12(gene name synonym)|uniprotkb:GTPase-activating Rap/Ran-GAP domain-like 1(gene name synonym)|uniprotkb:Tuberin-like protein 1(gene name synonym)|uniprotkb:p240(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_001269972.1|refseq:NP_001269973.1|refseq:NP_055805.1|refseq:NP_919277.2|refseq:NP_001333172.1|refseq:NP_001333174.1|refseq:NP_001333175.1|refseq:NP_001333176.1|refseq:NP_001333177.1|refseq:NP_001333178.1|refseq:NP_001317004.1|ensembl:ENSG00000174373(gene)|ensembl:ENST00000389698(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027107|interpro:IPR035974|mint:Q6GYQ0|reactome:R-HSA-9013407 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:355FJfQ+hIi8gkQQ+IAsF6xHuKU9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:Q2NKX8 intact:EBI-14061656 intact:EBI-1042535|uniprotkb:Q8NCI1|uniprotkb:Q96H93|uniprotkb:Q9NXQ8|intact:EBI-2560904|ensembl:ENSP00000334675 psi-mi:o40939_hhv8(display_long) psi-mi:erc6l_human(display_long)|uniprotkb:ERCC6L(gene name)|psi-mi:ERCC6L(display_short)|uniprotkb:PICH(gene name synonym)|uniprotkb:ATP-dependent helicase ERCC6-like(gene name synonym)|uniprotkb:PLK1-interacting checkpoint helicase(gene name synonym)|uniprotkb:Tumor antigen BJ-HCC-15(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - refseq:NP_060139.2|ensembl:ENSG00000186871(gene)|ensembl:ENST00000334463(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0015616"(DNA translocase activity)|go:"GO:0016020"(membrane)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|rcsb pdb:5JNO|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:3HZtZq9pgDyQB+UcxtAQjHv7+7o9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:P30260 intact:EBI-14061656 intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530 psi-mi:o40939_hhv8(display_long) psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40939 uniprotkb:O95302 intact:EBI-14061656 intact:EBI-2906368|ensembl:ENSP00000242209|uniprotkb:B3KY35|uniprotkb:Q2M2A1|uniprotkb:Q3MIR7|uniprotkb:Q6IN76|uniprotkb:Q6P2N1|uniprotkb:Q96EX5|uniprotkb:Q96IJ9|uniprotkb:B7Z1G9|uniprotkb:B7Z6H3 psi-mi:o40939_hhv8(display_long) psi-mi:fkbp9_human(display_long)|uniprotkb:FKBP9(gene name)|psi-mi:FKBP9(display_short)|uniprotkb:FKBP60(gene name synonym)|uniprotkb:FKBP63(gene name synonym)|uniprotkb:FK506-binding protein 9(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:63 kDa FK506-binding protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061654|imex:IM-26114-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000122642(gene)|ensembl:ENST00000242209(transcript)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|reactome:R-HSA-390471|refseq:NP_009201.2|refseq:NP_001271270.1|refseq:NP_001271272.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:udX1RbCLhO8y5CpJZNEAnaUZe5Q37296 rogid:9PeB4FnsIjqdug53lgefYNAhpz09606 rigid:DgU1CyqFkSyASuSSElW/dIcC7eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9DUN1 uniprotkb:Q6PD62 intact:EBI-1647907|uniprotkb:Q2HR72 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:q9dun1_hhv8(display_long)|uniprotkb:vIRF-3(gene name)|psi-mi:vIRF-3(display_short)|uniprotkb:VIRF-3(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061750|imex:IM-26114-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|refseq:YP_001129413.1|interpro:IPR036388|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity) refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:D1UFtWRgdlBY44gXd7HSdW0kxK037296 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 rigid:qeErOTlaiJ7Aue9bjuM06oIRpbc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9DUN1 uniprotkb:Q9NVE7 intact:EBI-1647907|uniprotkb:Q2HR72 intact:EBI-726248|uniprotkb:Q53EU3|uniprotkb:Q5TA84|uniprotkb:Q7RTX3|uniprotkb:Q9H3X5|uniprotkb:B9DI84|ensembl:ENSP00000367727|ensembl:ENSP00000478189 psi-mi:q9dun1_hhv8(display_long)|uniprotkb:vIRF-3(gene name)|psi-mi:vIRF-3(display_short)|uniprotkb:VIRF-3(gene name synonym) psi-mi:pank4_human(display_long)|uniprotkb:PANK4(gene name)|psi-mi:PANK4(display_short)|uniprotkb:Inactive pantothenic acid kinase 4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061750|imex:IM-26114-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|refseq:YP_001129413.1|interpro:IPR036388|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity) refseq:NP_060686.2|ensembl:ENSG00000157881(gene)|ensembl:ENSG00000273494(gene)|ensembl:ENST00000378466(transcript)|ensembl:ENST00000615291(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016310"(phosphorylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR002791(Protein of unknown function DUF89)|interpro:IPR004567(Eukaryotic pantothenate kinase)|interpro:IPR015844(Pantothenate kinase, acetyl-CoA regulated, two-domain type)|interpro:IPR035073|interpro:IPR036075|interpro:IPR043129|reactome:R-HSA-196783 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:D1UFtWRgdlBY44gXd7HSdW0kxK037296 rogid:fkcF+SEQ2NhbGogc4l09ZgdAiP49606 rigid:qeErOTlaiJ7Aue9bjuM06oIRpbc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9DUM9 uniprotkb:P35556 intact:EBI-14061759 intact:EBI-6164392|ensembl:ENSP00000424571|ensembl:ENSP00000262464|uniprotkb:B4DU01|uniprotkb:Q59ES6 psi-mi:q9dum9_hhv8(display_long) psi-mi:fbn2_human(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061757|imex:IM-26114-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000976"(transcription cis-regulatory region binding)|interpro:IPR036388|interpro:IPR001346(Interferon regulatory factor) interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35556|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|interpro:IPR018097|ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|refseq:NP_001990.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:IIfJ1ue/shq9ujAJH6+UB0BnKjk37296 rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606 rigid:RWNOkEN7DKI5Ukpq3wu3P37BpjM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9DUM9 uniprotkb:Q9NW64 intact:EBI-14061759 intact:EBI-2602260|uniprotkb:A6NDM5|uniprotkb:O95607|uniprotkb:B4DLI9|ensembl:ENSP00000199814 psi-mi:q9dum9_hhv8(display_long) psi-mi:rbm22_human(display_long)|uniprotkb:RBM22(gene name)|psi-mi:RBM22(display_short)|uniprotkb:ZC3H16(gene name synonym)|uniprotkb:RNA-binding motif protein 22(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 16(gene name synonym)|uniprotkb:199G4(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061757|imex:IM-26114-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000976"(transcription cis-regulatory region binding)|interpro:IPR036388|interpro:IPR001346(Interferon regulatory factor) refseq:NP_060517.1|go:"GO:0035690"|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|interpro:IPR036855|interpro:IPR039171|rcsb pdb:2YTC|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|ensembl:ENST00000199814(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000086589(gene)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0033120"(positive regulation of RNA splicing) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:IIfJ1ue/shq9ujAJH6+UB0BnKjk37296 rogid:PjcPER8I/RBxwu3oACO1LHxzKAM9606 rigid:RWNOkEN7DKI5Ukpq3wu3P37BpjM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:P38646 intact:EBI-14061774 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:P48741 intact:EBI-14061774 intact:EBI-877656|uniprotkb:P19790 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:hsp77_human(display_long)|uniprotkb:Heat shock 70 kDa protein B(gene name synonym)|uniprotkb:HSPA7(gene name)|psi-mi:HSPA7(display_short)|uniprotkb:HSP70B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|reactome:R-HSA-3371453|interpro:IPR043129 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:ZXOhfWYdKdW1ek+VsKZyF/Zo84o9606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:O95816 intact:EBI-14061774 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:Q99615 intact:EBI-14061774 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:P22087 intact:EBI-14061774 intact:EBI-358318|uniprotkb:O75259|uniprotkb:Q6IAT5|uniprotkb:Q9UPI6|ensembl:ENSP00000221801|ensembl:ENSP00000487390|uniprotkb:B5BUE8 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:fbrl_human(display_long)|uniprotkb:FBL(gene name)|psi-mi:FBL(display_short)|uniprotkb:FIB1(gene name synonym)|uniprotkb:FLRN(gene name synonym)|uniprotkb:Histone-glutamine methyltransferase(gene name synonym)|uniprotkb:34 kDa nucleolar scleroderma antigen(gene name synonym)|uniprotkb:U6 snRNA 2'-O-methyltransferase fibrillarin(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) refseq:NP_001427.2|ensembl:ENSG00000105202(gene)|ensembl:ENSG00000280548(gene)|ensembl:ENST00000221801(transcript)|ensembl:ENST00000625241(transcript)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0001652"(granular component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0008649"(rRNA methyltransferase activity)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0031167"(rRNA methylation)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990258"(histone glutamine methylation)|go:"GO:1990259"(histone-glutamine methyltransferase activity)|interpro:IPR000692(Fibrillarin)|interpro:IPR020813|interpro:IPR029063|mint:P22087|rcsb pdb:2IPX|reactome:R-HSA-6790901|reactome:R-HSA-6791226|dip:DIP-27569N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:8m8FDRSxGNKNXpJMcWWbcHL3uss9606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:W6AVY5 uniprotkb:Q9Y6H1 intact:EBI-14061774 intact:EBI-2321769|uniprotkb:Q498C3|uniprotkb:Q6NZ50|ensembl:ENSP00000378812 psi-mi:w6avy5_hhv8(display_long)|uniprotkb:K12(gene name)|psi-mi:K12(display_short) psi-mi:chch2_human(display_long)|uniprotkb:CHCHD2(gene name)|psi-mi:CHCHD2(display_short)|uniprotkb:C7orf17(gene name synonym)|uniprotkb:HCV NS2 trans-regulated protein(gene name synonym)|uniprotkb:Aging-associated gene 10 protein(gene name synonym)|uniprotkb:AAG10(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061769|imex:IM-26114-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane) refseq:NP_057223.1|ensembl:ENSG00000106153(gene)|ensembl:ENST00000395422(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR010625(CHCH)|mint:Q9Y6H1|reactome:R-HSA-1268020 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:muaz7tGQHhIJzAFkDZ0qll2oLWY37296 rogid:fdx3lE51+yZ1k3uwh8/LDKJC+CQ9606 rigid:aIm2WPCQVIRjLyZ2ClyBOJqNnEM false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:O43615 intact:EBI-14061788 intact:EBI-861737|uniprotkb:Q8N193|uniprotkb:A8K0R9|uniprotkb:D6W664|ensembl:ENSP00000270538 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:tim44_human(display_long)|uniprotkb:TIMM44(gene name)|psi-mi:TIMM44(display_short)|uniprotkb:MIMT44(gene name synonym)|uniprotkb:TIM44(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_006342.2|ensembl:ENSG00000104980(gene)|ensembl:ENST00000270538(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0051087"(chaperone binding)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR017303(Import inner membrane translocase, TIM44 subunit, mitochondria)|interpro:IPR032710|interpro:IPR039544|mint:O43615|rcsb pdb:2CW9|reactome:R-HSA-1268020 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:Hwln5XuF3a9IMwVhP63Ud+LM5M09606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q9GZT4 intact:EBI-14061788 intact:EBI-9055653|uniprotkb:D3DTI5|uniprotkb:Q6IA55|ensembl:ENSP00000339435 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:srr_human(display_long)|uniprotkb:SRR(gene name)|psi-mi:SRR(display_short)|uniprotkb:D-serine ammonia-lyase(gene name synonym)|uniprotkb:D-serine dehydratase(gene name synonym)|uniprotkb:L-serine ammonia-lyase(gene name synonym)|uniprotkb:L-serine dehydratase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_068766.1|refseq:XP_011522276.1|refseq:XP_006721628.1|refseq:XP_006721629.1|ensembl:ENSG00000167720(gene)|ensembl:ENST00000344595(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003941"(L-serine ammonia-lyase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008721"(D-serine ammonia-lyase activity)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0016594"(glycine binding)|go:"GO:0018114"(threonine racemase activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030378"(serine racemase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043278"(response to morphine)|go:"GO:0045177"(apical part of cell)|go:"GO:0070179"(D-serine biosynthetic process)|interpro:IPR000634(Serine/threonine dehydratase, pyridoxal-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR036052|rcsb pdb:3L6B|rcsb pdb:3L6R|rcsb pdb:5X2L|rcsb pdb:6SLH|rcsb pdb:6ZSP|rcsb pdb:6ZUJ|rcsb pdb:7NBC|rcsb pdb:7NBD|rcsb pdb:7NBF|rcsb pdb:7NBG|rcsb pdb:7NBH|reactome:R-HSA-977347|go:"GO:0070178"(D-serine metabolic process) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:+ShZCHr1gA5qAEHIFyg2yqVQqw09606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q14574 intact:EBI-14061788 intact:EBI-6163585|intact:EBI-28985956|uniprotkb:A6NN35|uniprotkb:Q14200|uniprotkb:Q9HAZ9|ensembl:ENSP00000353608 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:dsc3_human(display_long)|uniprotkb:Cadherin family member 3(gene name synonym)|uniprotkb:DSC4(gene name synonym)|uniprotkb:Desmocollin-4(gene name synonym)|uniprotkb:HT-CP(gene name synonym)|uniprotkb:DSC3(gene name)|psi-mi:DSC3(display_short)|uniprotkb:CDHF3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001932.2|refseq:NP_077741.2|ensembl:ENSP00000392068|ensembl:ENST00000434452|ensembl:ENSP00000353608|ensembl:ENSG00000134762(gene)|ensembl:ENST00000360428(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q14574|reactome:R-HSA-6805567|reactome:R-HSA-6809371|interpro:IPR002126(Cadherin) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:2En63we0WgDfQQY2f4qQHK/clSI9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:P36507 intact:EBI-14061788 intact:EBI-1056930|ensembl:ENSP00000262948|intact:EBI-15586042 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:mp2k2_human(display_long)|uniprotkb:MAP2K2(gene name)|psi-mi:MAP2K2(display_short)|uniprotkb:MEK2(gene name synonym)|uniprotkb:MKK2(gene name synonym)|uniprotkb:PRKMK2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_109587.1|ensembl:ENSG00000126934(gene)|ensembl:ENST00000262948(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36507|rcsb pdb:1S9I|rcsb pdb:4H3Q|reactome:R-HSA-112411|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|go:"GO:0005634"(nucleus)|dip:DIP-29119N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:JnGMm7dA0eZgBV4A/n+ZjE8ATq49606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q9UI12 intact:EBI-14061788 intact:EBI-724719|uniprotkb:Q6PK44|uniprotkb:Q9H3E3|uniprotkb:Q9Y300|uniprotkb:B3KMR0|ensembl:ENSP00000352522|ensembl:ENSP00000379995 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:vath_human(display_long)|uniprotkb:Vacuolar proton pump subunit H(gene name synonym)|uniprotkb:V-ATPase 50/57 kDa subunits(gene name synonym)|uniprotkb:Vacuolar proton pump subunit SFD(gene name synonym)|uniprotkb:Protein VMA13 homolog(gene name synonym)|uniprotkb:Nef-binding protein 1(gene name synonym)|uniprotkb:ATP6V1H(gene name)|psi-mi:ATP6V1H(display_short)|uniprotkb:CGI-11(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_057025.2|refseq:NP_998784.1|refseq:NP_998785.1|ensembl:ENSG00000047249(gene)|ensembl:ENST00000359530(transcript)|ensembl:ENST00000396774(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004908(ATPase, V1 complex, subunit H)|interpro:IPR011987(ATPase, V1 complex, subunit H, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038497|mint:Q9UI12|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-167590|reactome:R-HSA-182218|reactome:R-HSA-917977|reactome:R-HSA-9636467|reactome:R-HSA-9639288|reactome:R-HSA-983712|reactome:R-HSA-77387|refseq:XP_006716518.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:n2fyA8m4qnlSmS3R1xBBE3RRV9A9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q9Y287 intact:EBI-14061788 intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:P35221 intact:EBI-14061788 intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:O14733 intact:EBI-14061788 intact:EBI-492605|uniprotkb:O14648|uniprotkb:O14816|uniprotkb:O60452|uniprotkb:O60453|uniprotkb:Q1PG43|uniprotkb:Q8IY10|uniprotkb:B2R9S5|uniprotkb:D6W659|ensembl:ENSP00000381066 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:mp2k7_human(display_long)|uniprotkb:MAPK/ERK kinase 7(gene name synonym)|uniprotkb:JNK-activating kinase 2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase kinase 2(gene name synonym)|uniprotkb:MAP2K7(gene name)|psi-mi:MAP2K7(display_short)|uniprotkb:JNKK2(gene name synonym)|uniprotkb:MKK7(gene name synonym)|uniprotkb:PRKMK7(gene name synonym)|uniprotkb:MEK7(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 4(gene name synonym)|uniprotkb:SKK4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_660186.1|ensembl:ENSG00000076984(gene)|ensembl:ENST00000397979(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008545"(JUN kinase kinase activity)|go:"GO:0009408"(response to heat)|go:"GO:0009411"(response to UV)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:O14733|rcsb pdb:2DYL|rcsb pdb:3WZU|rcsb pdb:4UX9|rcsb pdb:5B2K|rcsb pdb:5B2L|rcsb pdb:5B2M|rcsb pdb:5Y8U|rcsb pdb:5Y90|rcsb pdb:5Z1D|rcsb pdb:5Z1E|rcsb pdb:6IB0|rcsb pdb:6IB2|go:"GO:0000187"(obsolete activation of MAPK activity)|rcsb pdb:6QFL|rcsb pdb:6QFR|rcsb pdb:6QFT|rcsb pdb:6QG4|rcsb pdb:6QG7|rcsb pdb:6QHO|rcsb pdb:6QHR|rcsb pdb:6YFZ|rcsb pdb:6YG0|rcsb pdb:6YG1|rcsb pdb:6YG2|rcsb pdb:6YG3|rcsb pdb:6YG4|rcsb pdb:6YG5|rcsb pdb:6YG6|rcsb pdb:6YG7|rcsb pdb:6YZ4|rcsb pdb:7CBX|reactome:R-HSA-2559580|reactome:R-HSA-2871796|reactome:R-HSA-5210891|reactome:R-HSA-450321|refseq:NP_001284484.1|refseq:NP_001284485.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:fEJqQ+bmZXzL9rSHk/Z01SQJFKM9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q8WUD6 intact:EBI-14061788 intact:EBI-11337856|uniprotkb:Q7Z7H1|uniprotkb:Q8WYI4|uniprotkb:Q8IWQ5|uniprotkb:Q7Z7H0|uniprotkb:Q9NRQ6|uniprotkb:B3KQM2|uniprotkb:Q9Y6M6|uniprotkb:Q9NRQ7|uniprotkb:Q7Z7H2|uniprotkb:Q8IWQ4|ensembl:ENSP00000229266 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:chpt1_human(display_long)|uniprotkb:CHPT1(gene name)|psi-mi:CHPT1(display_short)|uniprotkb:AAPT1-like protein(gene name synonym)|uniprotkb:CPT1(gene name synonym)|uniprotkb:Diacylglycerol cholinephosphotransferase 1(gene name synonym)|uniprotkb:MSTP022(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_064629.2|ensembl:ENSG00000111666(gene)|ensembl:ENST00000229266(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004142"(diacylglycerol cholinephosphotransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006656"(phosphatidylcholine biosynthetic process)|go:"GO:0006657"(CDP-choline pathway)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014472(Choline/ethanolaminephosphotransferase)|interpro:IPR043130|mint:Q8WUD6|reactome:R-HSA-1483191 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:4RFBPd6zmk0NFjCdHC01wIXZd989606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q6P587 intact:EBI-14061788 intact:EBI-597013|uniprotkb:Q6FIC7|uniprotkb:Q96RY1|uniprotkb:Q9H0N6|uniprotkb:B1AK41|uniprotkb:B1AK40|ensembl:ENSP00000398053 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:fahd1_human(display_long)|uniprotkb:FAHD1(gene name)|psi-mi:FAHD1(display_short)|uniprotkb:C16orf36(gene name synonym)|uniprotkb:Fumarylacetoacetate hydrolase domain-containing protein 1(gene name synonym)|uniprotkb:YISKL(gene name synonym)|uniprotkb:YisK-like protein(gene name synonym)|uniprotkb:Oxaloacetate decarboxylase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001018114.1|refseq:NP_001135870.1|refseq:NP_112485.1|ensembl:ENSG00000180185(gene)|ensembl:ENST00000427358(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0018773"(acetylpyruvate hydrolase activity)|go:"GO:0034545"(fumarylpyruvate hydrolase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0047621"(acylpyruvate hydrolase activity)|interpro:IPR011234(Fumarylacetoacetase, C-terminal-related)|interpro:IPR036663|rcsb pdb:1SAW|rcsb pdb:6FOG|rcsb pdb:6FOH|reactome:R-HSA-71403 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:+TBWTaRxrIz2Y0dfwkSNf8VZEcw9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:P36897 intact:EBI-14061788 intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q13308 intact:EBI-14061788 intact:EBI-2803245|uniprotkb:Q8NFA6|uniprotkb:Q5T650|uniprotkb:Q8NFA8|uniprotkb:Q13417|uniprotkb:Q6IQ54|uniprotkb:Q8NFA5|uniprotkb:Q8NFA7|uniprotkb:A8K974|uniprotkb:B7Z477|uniprotkb:E9PFZ5|ensembl:ENSP00000230419 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:ptk7_human(display_long)|uniprotkb:CCK4(gene name synonym)|uniprotkb:Colon carcinoma kinase 4(gene name synonym)|uniprotkb:Protein-tyrosine kinase 7(gene name synonym)|uniprotkb:PTK7(gene name)|psi-mi:PTK7(display_short)|uniprotkb:Pseudo tyrosine kinase receptor 7(gene name synonym)|uniprotkb:Tyrosine-protein kinase-like 7(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001257327.1|refseq:NP_002812.2|refseq:NP_690619.1|refseq:NP_690620.1|refseq:NP_690621.1|ensembl:ENSG00000112655(gene)|ensembl:ENST00000230419(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003401"(axis elongation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042060"(wound healing)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060026"(convergent extension)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q13308|rcsb pdb:6VG3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:O4L3LFD0WvN1hDb1abqVBbW1gis9606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40948 uniprotkb:Q68D85 intact:EBI-14061788 intact:EBI-14061804|uniprotkb:Q7Z3M6|ensembl:ENSP00000341637|ensembl:ENSP00000434394 psi-mi:o40948_hhv8(display_long)|uniprotkb:K14(gene name)|psi-mi:K14(display_short)|uniprotkb:HHV8GK18_gp83(orf name) psi-mi:nr3l1_human(display_long)|uniprotkb:NCR3LG1(gene name)|psi-mi:NCR3LG1(display_short)|uniprotkb:B7 homolog 6(gene name synonym)|uniprotkb:B7H6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061786|imex:IM-26114-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0050776"(regulation of immune response)|interpro:IPR036179|interpro:IPR033321|refseq:YP_001129432.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set) refseq:NP_001189368.1|ensembl:ENSG00000188211(gene)|ensembl:ENST00000338965(transcript)|ensembl:ENST00000530403(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR036946|rcsb pdb:3PV6|rcsb pdb:3PV7|rcsb pdb:4ZSO|rcsb pdb:6YJP|reactome:R-HSA-198933|dip:DIP-59940N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/13 rogid:a748uf3Fjrk86SWL1qmRA2z8NYM37296 rogid:zxyF+bJz/qWtsilosYWPqwnDUw89606 rigid:ez0r6vzknKO0RAG2tZ2h5KC3zrg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40918 uniprotkb:P55084 intact:EBI-14061847 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:o40918_hhv8(display_long)|uniprotkb:K2(gene name)|psi-mi:K2(display_short) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061845|imex:IM-26114-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR003574(Interleukin-6)|interpro:IPR030474|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0030683"(mitigation of host immune response by virus) refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Fa3Go5t+hqauzofRYbtBLfdofsg37296 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 rigid:dAfIOqxYzsnRVQkEEMzNz37OHgI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40918 uniprotkb:P14314 intact:EBI-14061847 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:o40918_hhv8(display_long)|uniprotkb:K2(gene name)|psi-mi:K2(display_short) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061845|imex:IM-26114-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR003574(Interleukin-6)|interpro:IPR030474|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0030683"(mitigation of host immune response by virus) refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Fa3Go5t+hqauzofRYbtBLfdofsg37296 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 rigid:dAfIOqxYzsnRVQkEEMzNz37OHgI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40918 uniprotkb:Q14697 intact:EBI-14061847 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:o40918_hhv8(display_long)|uniprotkb:K2(gene name)|psi-mi:K2(display_short) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061845|imex:IM-26114-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR003574(Interleukin-6)|interpro:IPR030474|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0030683"(mitigation of host immune response by virus) ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Fa3Go5t+hqauzofRYbtBLfdofsg37296 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 rigid:dAfIOqxYzsnRVQkEEMzNz37OHgI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40918 uniprotkb:P40189 intact:EBI-14061847 intact:EBI-1030834|uniprotkb:Q9UQ41|ensembl:ENSP00000338799|ensembl:ENSP00000370698|ensembl:ENSP00000462158|uniprotkb:A0N0L4|uniprotkb:Q5FC04 psi-mi:o40918_hhv8(display_long)|uniprotkb:K2(gene name)|psi-mi:K2(display_short) psi-mi:il6rb_human(display_long)|uniprotkb:IL6ST(gene name)|psi-mi:IL6ST(display_short)|uniprotkb:Interleukin-6 signal transducer(gene name synonym)|uniprotkb:Membrane glycoprotein 130(gene name synonym)|uniprotkb:CDw130(gene name synonym)|uniprotkb:Oncostatin-M receptor subunit alpha(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061845|imex:IM-26114-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR003574(Interleukin-6)|interpro:IPR030474|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0030683"(mitigation of host immune response by virus) ensembl:ENSG00000134352(gene)|ensembl:ENST00000336909(transcript)|ensembl:ENST00000381298(transcript)|ensembl:ENST00000502326(transcript)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004897"(ciliary neurotrophic factor receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|refseq:NP_002175.2|refseq:NP_786943.1|rcsb pdb:1BJ8|rcsb pdb:1BQU|rcsb pdb:1I1R|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:1PVH|rcsb pdb:3L5H|rcsb pdb:3L5I|rcsb pdb:3L5J|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6788467|reactome:R-HSA-8984722|reactome:R-HSA-9020956|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045509"(interleukin-27 receptor activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|mint:P40189|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0005900"(oncostatin-M receptor complex)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0030425"(dendrite)|refseq:NP_001177910.1|dip:DIP-95N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Fa3Go5t+hqauzofRYbtBLfdofsg37296 rogid:0DhlsbEh3ZiKomQFf+5mjd6hUOM9606 rigid:dAfIOqxYzsnRVQkEEMzNz37OHgI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40918 uniprotkb:P27824 intact:EBI-14061847 intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3 psi-mi:o40918_hhv8(display_long)|uniprotkb:K2(gene name)|psi-mi:K2(display_short) psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061845|imex:IM-26114-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR003574(Interleukin-6)|interpro:IPR030474|go:"GO:0005125"(cytokine activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0030683"(mitigation of host immune response by virus) refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Fa3Go5t+hqauzofRYbtBLfdofsg37296 rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606 rigid:dAfIOqxYzsnRVQkEEMzNz37OHgI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96HA1 uniprotkb:D0UZL9 intact:EBI-739990|ensembl:ENSP00000405562|uniprotkb:A8MXF9|uniprotkb:O75115|uniprotkb:Q9Y4S7|intact:EBI-948778|uniprotkb:A6NFS9|uniprotkb:A8CDT4|uniprotkb:A8K933|uniprotkb:Q96DI0|uniprotkb:Q9H9X1|uniprotkb:Q9Y2N3 intact:EBI-14061868 psi-mi:p121a_human(display_long)|uniprotkb:POM121(gene name)|psi-mi:POM121(display_short)|uniprotkb:KIAA0618(gene name synonym)|uniprotkb:NUP121(gene name synonym)|uniprotkb:POM121A(gene name synonym)|uniprotkb:Pore membrane protein of 121 kDa(gene name synonym)|uniprotkb:Nuclear envelope pore membrane protein POM 121A(gene name synonym)|uniprotkb:Nucleoporin Nup121(gene name synonym) psi-mi:d0uzl9_hhv8(display_long)|uniprotkb:K3(gene name)|psi-mi:K3(display_short)|uniprotkb:HHV8GK18_gp11(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061866|imex:IM-26114-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000196313(gene)|ensembl:ENST00000434423(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051028"(mRNA transport)|interpro:IPR026054|interpro:IPR026090|rcsb pdb:5T6W|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|refseq:NP_001244119.1|ensembl:ENST00000358357|ensembl:ENSP00000351124|ensembl:ENST00000395270|ensembl:ENSP00000378687|ensembl:ENSP00000405562|ensembl:ENST00000446813|ensembl:ENSP00000393020|ensembl:ENST00000627934|ensembl:ENSP00000486504|reactome:R-HSA-165054|refseq:NP_742017.1|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005250783.1|refseq:XP_006716259.1|refseq:XP_016868342.1|refseq:XP_016868343.1 interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:lQ9VaBl42KMRJaM4UdF4ng9ZX549606 rogid:B4CoRcw5VgjZFXC88Q1c0gThUPI37296 rigid:pajgDKZwXLY/7tFpUNLQZFLeBx8 false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFL9 uniprotkb:Q8WV44 intact:EBI-14032776 intact:EBI-725997|uniprotkb:Q5BKT0|uniprotkb:Q7L484|uniprotkb:Q96Q10|intact:EBI-1551110|uniprotkb:Q9BSL8|uniprotkb:B3KNJ6|uniprotkb:D3DWR9|ensembl:ENSP00000320869 psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:tri41_human(display_long)|uniprotkb:TRIM41(gene name)|psi-mi:TRIM41(display_short)|uniprotkb:RINCK(gene name synonym)|uniprotkb:Tripartite motif-containing protein 41(gene name synonym)|uniprotkb:RING finger-interacting protein with C kinase(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM41(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061881|imex:IM-26114-105 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 refseq:NP_291027.3|refseq:NP_963921.1|ensembl:ENSG00000146063(gene)|ensembl:ENST00000315073(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0042802"(identical protein binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042828|interpro:IPR043136|mint:Q8WV44|rcsb pdb:2EGM|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rogid:BVqf0OHXPGsYe8F66mHzvD4XQ549606 rigid:UBhL4hJ7P7I3TUBPiTgbyRC60hw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFL9 uniprotkb:P62310 intact:EBI-14032776 intact:EBI-348239|ensembl:ENSP00000302160|uniprotkb:Q9Y4Z1|uniprotkb:Q6IAH0 psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:lsm3_human(display_long)|uniprotkb:MDS017(orf name)|uniprotkb:LSM3(gene name)|psi-mi:LSM3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061881|imex:IM-26114-105 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 ensembl:ENSG00000170860(gene)|ensembl:ENST00000306024(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0030629"(U6 snRNA 3'-end binding)|go:"GO:0033962"(P-body assembly)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034105|interpro:IPR040002|mint:P62310|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:NP_055278.1|dip:DIP-31218N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rogid:+OnRI9eJcsd1xJe+cUCP7Y/9tt09606 rigid:UBhL4hJ7P7I3TUBPiTgbyRC60hw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFL9 uniprotkb:O43172 intact:EBI-14032776 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061881|imex:IM-26114-105 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rigid:UBhL4hJ7P7I3TUBPiTgbyRC60hw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFL9 uniprotkb:O43395 intact:EBI-14032776 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061881|imex:IM-26114-105 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 rigid:UBhL4hJ7P7I3TUBPiTgbyRC60hw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFL9 uniprotkb:Q15020 intact:EBI-14032776 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061881|imex:IM-26114-105 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rigid:UBhL4hJ7P7I3TUBPiTgbyRC60hw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q9H4L4 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-2880236|ensembl:ENSP00000314029|ensembl:ENSP00000403712|uniprotkb:Q96PS4|uniprotkb:Q66K15|uniprotkb:Q86VS7|uniprotkb:Q9Y3W9 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:senp3_human(display_long)|uniprotkb:SENP3(gene name)|psi-mi:SENP3(display_short)|uniprotkb:SSP3(gene name synonym)|uniprotkb:SUSP3(gene name synonym)|uniprotkb:SUMO-1-specific protease 3(gene name synonym)|uniprotkb:Sentrin/SUMO-specific protease SENP3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 ensembl:ENSG00000161956(gene)|ensembl:ENST00000321337(transcript)|ensembl:ENST00000429205(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016926"(protein desumoylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003653(Peptidase C48, SUMO/Sentrin/Ubl1)|interpro:IPR037945|interpro:IPR038765|mint:Q9H4L4|reactome:R-HSA-6791226|refseq:NP_056485.2|dip:DIP-47511N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:sE4k87ORoxSjBkbccPsXLYzuqII9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q9Y2B0 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-1054195|uniprotkb:Q9UHE9|uniprotkb:B2R7B9|ensembl:ENSP00000273308 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:cnpy2_human(display_long)|uniprotkb:TMEM4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein Zsig9(gene name synonym)|uniprotkb:CNPY2(gene name)|psi-mi:CNPY2(display_short)|uniprotkb:MSAP(gene name synonym)|uniprotkb:ZSIG9(gene name synonym)|uniprotkb:UNQ1943/PRO4426(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 refseq:NP_001177920.1|refseq:NP_055070.1|ensembl:ENSG00000257727(gene)|ensembl:ENST00000273308(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9Y2B0|dip:DIP-50705N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:m8AFLt3+Fjh99ImqcKladnb00jU9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q9BV38 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-727429|uniprotkb:O60390|uniprotkb:Q9BWR2|intact:EBI-28969560|ensembl:ENSP00000476117 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:wdr18_human(display_long)|uniprotkb:WDR18(gene name)|psi-mi:WDR18(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 refseq:NP_077005.2|ensembl:ENSP00000476117|go:"GO:0097344"(Rix1 complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026987|interpro:IPR036322|mint:Q9BV38|reactome:R-HSA-6791226|ensembl:ENSG00000065268(gene)|ensembl:ENST00000585809(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:03RKz4c6MKJvOePaNrKeInnS6Lg9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q5SY16 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-1055462|uniprotkb:Q4VBY3|uniprotkb:Q6P472|uniprotkb:Q7L4D6|uniprotkb:Q96EE0|uniprotkb:Q9H5L4|uniprotkb:Q2NL84|ensembl:ENSP00000366934 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:nol9_human(display_long)|uniprotkb:NOL9(gene name)|psi-mi:NOL9(display_short)|uniprotkb:Nucleolar protein 9(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 refseq:NP_078930.3|refseq:XP_011540449.1|ensembl:ENST00000377705(transcript)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006396"(RNA processing)|go:"GO:0016020"(membrane)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051731"(polynucleotide 5'-hydroxyl-kinase activity)|interpro:IPR027417|interpro:IPR032319|mint:Q5SY16|reactome:R-HSA-6791226|ensembl:ENSG00000162408(gene)|refseq:XP_016857827.1|refseq:XP_016857828.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:IWGhuh/G+MlTxlSXEcIml8tvK7Y9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q8IZL8 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-716449|intact:EBI-28969510|ensembl:ENSP00000460300|ensembl:ENSP00000461625|uniprotkb:O15450|uniprotkb:Q5EGN3|uniprotkb:Q6NTE6|uniprotkb:Q96FT1|uniprotkb:Q9BU60 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:pelp1_human(display_long)|uniprotkb:Modulator of non-genomic activity of estrogen receptor(gene name synonym)|uniprotkb:Transcription factor HMX3(gene name synonym)|uniprotkb:PELP1(gene name)|psi-mi:PELP1(display_short)|uniprotkb:HMX3(gene name synonym)|uniprotkb:MNAR(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 ensembl:ENSG00000141456(gene)|ensembl:ENST00000572293(transcript)|ensembl:ENST00000574876(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016020"(membrane)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071391"(cellular response to estrogen stimulus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012583(NUC201)|interpro:IPR016024(Armadillo-type fold)|mint:Q8IZL8|reactome:R-HSA-6791226|reactome:R-HSA-8849473|interpro:IPR012980(Protein of unknown function NUC202)|ensembl:ENSP00000460300|ensembl:ENSP00000461625|refseq:NP_055204.3|refseq:NP_001265170.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:iu03DsintVoo3gWzZX14SlHE0ao9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q86XK2 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-1047804|uniprotkb:Q9H9L1|uniprotkb:Q9NR14|uniprotkb:Q9UFK1|uniprotkb:Q52ZP1|uniprotkb:Q53EP7|uniprotkb:Q8IXG3|uniprotkb:Q96E90|uniprotkb:Q9H6V8|uniprotkb:Q9UHI1|uniprotkb:Q9UKC2|uniprotkb:Q53RT5|uniprotkb:A1L491|ensembl:ENSP00000384823 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:fbx11_human(display_long)|uniprotkb:Vitiligo-associated protein 1(gene name synonym)|uniprotkb:FBXO11(gene name)|psi-mi:FBXO11(display_short)|uniprotkb:FBX11(gene name synonym)|uniprotkb:VIT1(gene name synonym)|uniprotkb:PRMT9(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 9(gene name synonym)|uniprotkb:UG063H01(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 refseq:NP_001177203.1|refseq:XP_016860506.1|refseq:NP_079409.3|refseq:XP_005264629.1|dip:DIP-35680N|ensembl:ENSG00000138081(gene)|ensembl:ENST00000403359(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR006633(Carbohydrate-binding and sugar hydrolysis)|interpro:IPR007742(Periplasmic copper-binding)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR022441|interpro:IPR029799|interpro:IPR036047|interpro:IPR039448|rcsb pdb:5VMD|reactome:R-HSA-8951664|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:7tSKElIYe8osUxG4NtKI0lWkLak9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P88968 uniprotkb:Q9NXF1 intact:EBI-14061893|uniprotkb:Q2HRC2 intact:EBI-2371062|uniprotkb:Q5T722|uniprotkb:Q5T723|uniprotkb:Q8NCN8|uniprotkb:Q8TDY0|uniprotkb:B4DYV2|ensembl:ENSP00000364037 psi-mi:p88968_hhv8(display_long)|uniprotkb:BCK(gene name)|psi-mi:BCK(display_short)|uniprotkb:K4.1(gene name synonym)|uniprotkb:HHV8GK18_gp15(orf name) psi-mi:tex10_human(display_long)|uniprotkb:TEX10(gene name)|psi-mi:TEX10(display_short)|uniprotkb:L18(orf name)|uniprotkb:Nbla10363(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061891|imex:IM-26114-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129363.1|interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048 refseq:NP_060216.2|refseq:NP_001155056.1|ensembl:ENSG00000136891(gene)|ensembl:ENST00000374902(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0071339"(MLL1 complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024679|interpro:IPR037947|mint:Q9NXF1|reactome:R-HSA-6791226 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:WpBYngjOiGwsWxQKWnrk+ubdytk37296 rogid:cQcRo1eExRkr/an7wvBN8Ttyatc9606 rigid:FXfecVhizCu/IemedeTVFA68Vvw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40921 uniprotkb:Q5T0T0 intact:EBI-14061916|uniprotkb:Q2HRC1 intact:EBI-14061946|uniprotkb:B2R8E7|uniprotkb:H0Y7C6|uniprotkb:Q5T0S8|uniprotkb:Q8TC72|ensembl:ENSP00000317087|ensembl:ENSP00000379116|ensembl:ENSP00000379118 psi-mi:o40921_hhv8(display_long)|uniprotkb:K4.2(gene name)|psi-mi:K4.2(display_short)|uniprotkb:KIE-3(gene name synonym)|uniprotkb:HHV8GK18_gp14(orf name) psi-mi:marh8_human(display_long)|uniprotkb:MARCHF8(gene name)|psi-mi:MARCHF8(display_short)|uniprotkb:Cellular modulator of immune recognition(gene name synonym)|uniprotkb:MARCH8(gene name synonym)|uniprotkb:MIR(gene name synonym)|uniprotkb:Membrane-associated RING finger protein 8(gene name synonym)|uniprotkb:Membrane-associated RING-CH protein VIII(gene name synonym)|uniprotkb:RING finger protein 178(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MARCHF8(gene name synonym)|uniprotkb:RNF178(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061914|imex:IM-26114-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129364.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001002266.1|refseq:NP_001269795.1|refseq:NP_659458.2|refseq:XP_005271861.1|refseq:XP_006717767.1|refseq:XP_011537794.1|refseq:XP_011537795.1|refseq:XP_011537796.1|refseq:XP_011537797.1|refseq:XP_016871383.1|ensembl:ENSG00000165406(gene)|ensembl:ENSG00000278545(gene)|ensembl:ENST00000319836(transcript)|ensembl:ENST00000395769(transcript)|ensembl:ENST00000395771(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002495"(antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042287"(MHC protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|rcsb pdb:2D8S - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:KRVxJIlO3p9g7UNh7k+B+MhdKNs37296 rogid:sa4MKZWpkXIIqtEfH27MkBTxFMY9606 rigid:otIU2X/RVPVws0EbMyhhQBJycos false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40921 uniprotkb:P10075 intact:EBI-14061916|uniprotkb:Q2HRC1 intact:EBI-14061927|uniprotkb:Q96CK9|ensembl:ENSP00000345024|ensembl:ENSP00000430987 psi-mi:o40921_hhv8(display_long)|uniprotkb:K4.2(gene name)|psi-mi:K4.2(display_short)|uniprotkb:KIE-3(gene name synonym)|uniprotkb:HHV8GK18_gp14(orf name) psi-mi:gli4_human(display_long)|uniprotkb:Krueppel-related zinc finger protein 4(gene name synonym)|uniprotkb:Protein HKR4(gene name synonym)|uniprotkb:GLI4(gene name)|psi-mi:GLI4(display_short)|uniprotkb:HKR4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061914|imex:IM-26114-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129364.1|go:"GO:0016021"(integral component of membrane) refseq:NP_612474.1|ensembl:ENSG00000250571(gene)|ensembl:ENST00000340042(transcript)|ensembl:ENST00000523522(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:KRVxJIlO3p9g7UNh7k+B+MhdKNs37296 rogid:yfpNQFDrSdD16QG1Snld8RhqUZ09606 rigid:otIU2X/RVPVws0EbMyhhQBJycos false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5H9K4 uniprotkb:O75787 intact:EBI-14061993 intact:EBI-2512037|ensembl:ENSP00000490083|uniprotkb:B7Z9I3|uniprotkb:Q8NG15|uniprotkb:Q8NBP3|uniprotkb:Q5QTQ7|uniprotkb:Q9UG89|uniprotkb:Q96FV6|uniprotkb:Q9H2P8|uniprotkb:Q96LB5|uniprotkb:Q6T7F5 psi-mi:f5h9k4_hhv8(display_long)|uniprotkb:K5(gene name)|psi-mi:K5(display_short)|uniprotkb:HHV8GK18_gp16(orf name) psi-mi:renr_human(display_long)|uniprotkb:ATP6AP2(gene name)|psi-mi:ATP6AP2(display_short)|uniprotkb:ATP6IP2(gene name synonym)|uniprotkb:CAPER(gene name synonym)|uniprotkb:ELDF10(gene name synonym)|uniprotkb:Renin/prorenin receptor(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal accessory protein 2"(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal-interacting protein 2"(gene name synonym)|uniprotkb:Vacuolar ATP synthase membrane sector-associated protein M8-9(gene name synonym)|uniprotkb:N14F(gene name synonym)|uniprotkb:Embryonic liver differentiation factor 10(gene name synonym)|uniprotkb:HT028(orf name)|uniprotkb:MSTP009(orf name)|uniprotkb:PSEC0072(orf name)|uniprotkb:ER-localized type I transmembrane adapter(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061991|imex:IM-26114-149 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001841(Zinc finger, RING-type)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|refseq:YP_001129365.1|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) ensembl:ENSG00000182220(gene)|ensembl:ENST00000636580(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048069"(eye pigmentation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR012493(Renin receptor-like)|mint:O75787|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:NP_005756.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Rkqad9bfs+NNV26Z2bkng1xQ+4I37296 rogid:v4lEPX23LdYqPi8dQX4MZG+tQZg9606 rigid:wK2pR75ioqd8KAbkhH4h530kprI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5H9K4 uniprotkb:Q7Z6M1 intact:EBI-14061993 intact:EBI-3914588|uniprotkb:Q69YR2|uniprotkb:Q86Y76|uniprotkb:Q9BWB1|uniprotkb:Q6IBG7|uniprotkb:Q6P092|uniprotkb:O00568|uniprotkb:Q6FHA4|uniprotkb:A8K403|intact:EBI-28977166|ensembl:ENSP00000362639|ensembl:ENSP00000377683 psi-mi:f5h9k4_hhv8(display_long)|uniprotkb:K5(gene name)|psi-mi:K5(display_short)|uniprotkb:HHV8GK18_gp16(orf name) psi-mi:rabek_human(display_long)|uniprotkb:RABEPK(gene name)|psi-mi:RABEPK(display_short)|uniprotkb:RAB9P40(gene name synonym)|uniprotkb:40 kDa Rab9 effector protein(gene name synonym)|uniprotkb:p40(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14061991|imex:IM-26114-149 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001841(Zinc finger, RING-type)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|refseq:YP_001129365.1|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) ensembl:ENST00000259460|ensembl:ENSP00000259460|ensembl:ENSP00000362639|ensembl:ENSP00000377683|refseq:NP_001167623.1|refseq:NP_001167624.1|refseq:NP_005824.2|refseq:XP_016869666.1|ensembl:ENSG00000136933(gene)|ensembl:ENST00000373538(transcript)|ensembl:ENST00000394125(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0032588"(trans-Golgi network membrane)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011498(Kelch repeat type 2)|interpro:IPR015915(Kelch-type beta propeller)|reactome:R-HSA-6811440 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:Rkqad9bfs+NNV26Z2bkng1xQ+4I37296 rogid:iL/f1TBleqK3UX0iazUKQDaFLd89606 rigid:wK2pR75ioqd8KAbkhH4h530kprI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q7Z7L7 uniprotkb:Q76RJ0 intact:EBI-1811449|uniprotkb:O00156|uniprotkb:Q5T272|uniprotkb:Q5T273|ensembl:ENSP00000291900 intact:EBI-14062010|uniprotkb:Q2HRB9 psi-mi:zer1_human(display_long)|uniprotkb:Zyg-11 homolog B-like protein(gene name synonym)|uniprotkb:Hzyg(gene name synonym)|uniprotkb:ZER1(gene name)|psi-mi:ZER1(display_short)|uniprotkb:C9orf60(gene name synonym)|uniprotkb:ZYG(gene name synonym)|uniprotkb:ZYG11BL(gene name synonym)|uniprotkb:Zyg11b-like protein(gene name synonym) psi-mi:q76rj0_hhv8(display_long)|uniprotkb:K6(gene name)|psi-mi:K6(display_short)|uniprotkb:HHV8GK18_gp17(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062008|imex:IM-26114-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006327.2|refseq:XP_011516424.1|refseq:XP_016869674.1|refseq:XP_005251702.1|ensembl:ENSG00000160445(gene)|ensembl:ENST00000291900(transcript)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR032675|interpro:IPR040368|mint:Q7Z7L7 go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|interpro:IPR036048|refseq:YP_001129366.1|rcsb pdb:1ZXT|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR039809 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/14 rogid:IWzURpjsw2cGVyaAkJhttRDlxzc9606 rogid:q6eUDbcLiFJU+7YLW7LsXT7Yvvc37296 rigid:YapvxYH/ChBmnCTWbdDr/Uagwvw false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q86T03 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6164623|uniprotkb:B2RA35|uniprotkb:Q86U09|uniprotkb:Q8WUC0|uniprotkb:Q9BU67|uniprotkb:Q9NSU8|ensembl:ENSP00000250489 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:pp4p1_human(display_long)|uniprotkb:PIP4P1(gene name)|psi-mi:PIP4P1(display_short)|uniprotkb:C14orf9(gene name synonym)|uniprotkb:PtdIns-4,5-P2 4-Ptase I(gene name synonym)|uniprotkb:TMEM55B(gene name synonym)|uniprotkb:Transmembrane protein 55B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSP00000250489|ensembl:ENST00000398020|ensembl:ENSP00000381102|refseq:NP_001094284.1|refseq:NP_653169.2|ensembl:ENSG00000165782(gene)|ensembl:ENST00000250489(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0070070"(proton-transporting V-type ATPase complex assembly)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR019178|reactome:R-HSA-6811555|reactome:R-HSA-8847453 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:nbc8AvBd7g6bpNjfhhK7aPZ0BYk9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9Y6C9 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6164522|ensembl:ENSP00000303222|ensembl:ENSP00000495027|uniprotkb:B2R7L8 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:mtch2_human(display_long)|uniprotkb:MTCH2(gene name)|psi-mi:MTCH2(display_short)|uniprotkb:MIMP(gene name synonym)|uniprotkb:Met-induced mitochondrial protein(gene name synonym)|uniprotkb:HSPC032(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) interpro:IPR018108|interpro:IPR023395|mint:Q9Y6C9|go:"GO:0070585"(protein localization to mitochondrion)|ensembl:ENSG00000109919(gene)|ensembl:ENSG00000285121(gene)|ensembl:ENST00000302503(transcript)|ensembl:ENST00000643223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|refseq:NP_001304160.1|refseq:NP_001304161.1|refseq:NP_001304162.1|refseq:NP_055157.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:Lbg7MBRn09cRzoYOiSt4g4FjsjA9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96QT4 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-8042878|uniprotkb:Q86VJ4|uniprotkb:Q8NBW2|uniprotkb:Q6ZMF5|uniprotkb:Q9NXQ2|uniprotkb:Q9BXB2|intact:MINT-2815126|intact:EBI-28970210|ensembl:ENSP00000495860 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:trpm7_human(display_long)|uniprotkb:TRPM7(gene name)|psi-mi:TRPM7(display_short)|uniprotkb:CHAK1(gene name synonym)|uniprotkb:LTRPC7(gene name synonym)|uniprotkb:Long transient receptor potential channel 7(gene name synonym)|uniprotkb:Channel-kinase 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSP00000495860|refseq:NP_001288141.1|refseq:NP_060142.3|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR004166(MHCK/EF2 kinase)|interpro:IPR005821(Ion transport)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029601|interpro:IPR032415|interpro:IPR037162|interpro:IPR041491|mint:Q96QT4|reactome:R-HSA-3295583|ensembl:ENSG00000092439(gene)|ensembl:ENST00000646667(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016340"(calcium-dependent cell-matrix adhesion)|go:"GO:0017022"(myosin binding)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070266"(necroptotic process)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0072507"(divalent inorganic cation homeostasis)|go:"GO:0098655"(cation transmembrane transport) - comment:mint function:"Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1)"|comment:mint|function:"Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual" figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:IS+9n5E30il3gw+TXN1nbwV4ORk9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O75431 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-7415268|uniprotkb:Q53SQ2|uniprotkb:Q5M7Z6|uniprotkb:A8JZZ4|intact:MINT-3001232|intact:MINT-4876050|uniprotkb:Q53S50|ensembl:ENSP00000249442|uniprotkb:Q8IZ68 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:mtx2_human(display_long)|uniprotkb:MTX2(gene name)|psi-mi:MTX2(display_short)|uniprotkb:Mitochondrial outer membrane import complex protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001306026.1|refseq:NP_001306027.1|refseq:NP_001006636.1|refseq:NP_006545.1|ensembl:ENSG00000128654(gene)|ensembl:ENST00000249442(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0015031"(protein transport)|interpro:IPR019564|interpro:IPR033468|interpro:IPR036282|interpro:IPR040079|mint:O75431|reactome:R-HSA-1268020|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex) - comment:mint comment:mint|function:Involved in transport of proteins into the mitochondrion figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:M4zfGX8gfFUFW7xYoXeEzA2UCSM9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q99735 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-11324706|uniprotkb:D6RBB5|uniprotkb:Q7Z5B8|ensembl:ENSP00000265498|ensembl:ENSP00000423008|ensembl:ENSP00000482639 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:mgst2_human(display_long)|uniprotkb:Glutathione peroxidase MGST2(gene name synonym)|uniprotkb:Leukotriene C4 synthase MGST2(gene name synonym)|uniprotkb:Microsomal glutathione S-transferase II(gene name synonym)|uniprotkb:MGST2(gene name)|psi-mi:MGST2(display_short)|uniprotkb:GST2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001191295.1|refseq:NP_001191297.1|refseq:NP_002404.1|ensembl:ENSG00000085871(gene)|ensembl:ENST00000265498(transcript)|ensembl:ENST00000503816(transcript)|ensembl:ENST00000616265(transcript)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004464"(leukotriene-C4 synthase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006750"(glutathione biosynthetic process)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043295"(glutathione binding)|go:"GO:0046466"(membrane lipid catabolic process)|go:"GO:0050729"(positive regulation of inflammatory response)|interpro:IPR001129("Membrane-associated, eicosanoid and glutathione metabolism (MAPEG)")|interpro:IPR001446(5-lipoxygenase-activating protein)|interpro:IPR018295|interpro:IPR023352|rcsb pdb:6SSR|rcsb pdb:6SSS|rcsb pdb:6SSU|rcsb pdb:6SSW|reactome:R-HSA-156590|reactome:R-HSA-5423646|refseq:XP_016863700.1|refseq:XP_016863701.1|refseq:XP_016863702.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:Jxxwq73wI9wwTlWwkDOJCe+W3lA9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96DZ1 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96P47 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6873422|uniprotkb:Q96RK3|uniprotkb:Q59EN0|uniprotkb:B3KNZ8|uniprotkb:E9PAL8|ensembl:ENSP00000480655 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:agap3_human(display_long)|uniprotkb:CENTG3(gene name synonym)|uniprotkb:CRAM-associated GTPase(gene name synonym)|uniprotkb:Centaurin-gamma-3(gene name synonym)|uniprotkb:MR1-interacting protein(gene name synonym)|uniprotkb:AGAP3(gene name)|psi-mi:AGAP3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001268229.1|refseq:XP_016867223.1|refseq:NP_114152.3|refseq:NP_001036000.1|ensembl:ENSG00000133612(gene)|ensembl:ENST00000622464(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0071944"(cell periphery)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q96P47|rcsb pdb:3IHW - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:kfyXrwC5SFjflXEMQ2wfKoB98Ig9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O94822 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1044684|uniprotkb:Q9H8M4|uniprotkb:Q9NUY5|uniprotkb:Q9P0E9|uniprotkb:A7E2D0|uniprotkb:B2RTS0|uniprotkb:C9J7U3|uniprotkb:Q05C47|uniprotkb:A6NL41|uniprotkb:J3KPL4|intact:EBI-11051127|ensembl:ENSP00000354977|ensembl:ENSP00000373846 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ltn1_human(display_long)|uniprotkb:LTN1(gene name)|psi-mi:LTN1(display_short)|uniprotkb:ZNF294(gene name synonym)|uniprotkb:C21orf10(gene name synonym)|uniprotkb:C21orf98(gene name synonym)|uniprotkb:KIAA0714(gene name synonym)|uniprotkb:HSPC087(orf name)|uniprotkb:Zinc finger protein 294(gene name synonym)|uniprotkb:RNF160(gene name synonym)|uniprotkb:RING finger protein 160(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase listerin(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_056380.2|refseq:NP_001307695.1|ensembl:ENSG00000198862(gene)|ensembl:ENST00000361371(transcript)|ensembl:ENST00000389194(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039795|interpro:IPR039804|rcsb pdb:3J92|reactome:R-HSA-983168 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:ysR3JH2PPNrc1EwOpusyQoGrYFw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q6YHU6 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2824523|uniprotkb:Q3KR04|uniprotkb:Q53RC6|uniprotkb:Q6ZU38|uniprotkb:Q9H6W7|uniprotkb:Q6YHU2|uniprotkb:Q9C096|uniprotkb:Q96I88|uniprotkb:Q8TAU8|uniprotkb:Q9H6U0|uniprotkb:B7WNS6|uniprotkb:Q53TB2|uniprotkb:A8K1V8|intact:EBI-3213832|uniprotkb:Q9BZF7|ensembl:ENSP00000385995|ensembl:ENSP00000386088|uniprotkb:Q8IY32 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:thada_human(display_long)|uniprotkb:THADA(gene name)|psi-mi:THADA(display_short)|uniprotkb:GITA(gene name synonym)|uniprotkb:KIAA1767(gene name synonym)|uniprotkb:Gene inducing thyroid adenomas protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001332854.1|ensembl:ENSG00000115970(gene)|ensembl:ENST00000405006(transcript)|ensembl:ENST00000405975(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0030488"(tRNA methylation)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1990845"(adaptive thermogenesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019442|rcsb pdb:5T6Y|reactome:R-HSA-6782315|refseq:XP_006712128.1|refseq:NP_001077422.1|refseq:NP_071348.3|refseq:NP_001258572.1|refseq:NP_001258573.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:HLP/DNXyeZkkWzwOjvl/6A+U6eU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9UPT5 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-720048|uniprotkb:Q96FF0|uniprotkb:Q9H8C3|uniprotkb:Q9H9X3|uniprotkb:Q9HA32|uniprotkb:Q8ND93|uniprotkb:Q8WV91|uniprotkb:B5MC69|uniprotkb:B8XXP2|ensembl:ENSP00000334100 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:exoc7_human(display_long)|uniprotkb:EXOC7(gene name)|psi-mi:EXOC7(display_short)|uniprotkb:EXO70(gene name synonym)|uniprotkb:KIAA1067(gene name synonym)|uniprotkb:Exocyst complex component Exo70(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001013861.1|refseq:NP_001138769.1|refseq:NP_001138770.1|refseq:NP_001138771.1|refseq:NP_056034.2|ensembl:ENSG00000182473(gene)|ensembl:ENST00000335146(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032584"(growth cone membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR004140(Exo70 exocyst complex subunit)|interpro:IPR016159(Cullin repeat-like)|mint:Q9UPT5|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_001269242.1|dip:DIP-37604N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:f/uwscxIcAuG96QZzNMQtrzTmeU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9BYC5 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2869363|uniprotkb:Q9P2U6|uniprotkb:Q9P2U5|uniprotkb:O00235|uniprotkb:Q9BYC6|uniprotkb:B4DFS7|uniprotkb:G3V5N0|uniprotkb:Q8IUA5|ensembl:ENSP00000353910|ensembl:ENSP00000501213|ensembl:ENSP00000378087 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:fut8_human(display_long)|uniprotkb:FUT8(gene name)|psi-mi:FUT8(display_short)|uniprotkb:Fucosyltransferase 8(gene name synonym)|uniprotkb:"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase"(gene name synonym)|uniprotkb:GDP-fucose--glycoprotein fucosyltransferase(gene name synonym)|uniprotkb:Glycoprotein 6-alpha-L-fucosyltransferase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004471.4|refseq:NP_835368.1|refseq:NP_835369.1|ensembl:ENSG00000033170(gene)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6VLE|go:"GO:1900407"(regulation of cellular response to oxidative stress)|interpro:IPR001452(Src homology-3)|rcsb pdb:6X5H|interpro:IPR015827("Alpha-(1,6)-fucosyltransferase, eukaryotic type")|interpro:IPR027350|interpro:IPR035653|interpro:IPR036028|mint:Q9BYC5|rcsb pdb:2DE0|rcsb pdb:6VLD|rcsb pdb:6X5R|rcsb pdb:6X5S|rcsb pdb:6X5T|rcsb pdb:6X5U|reactome:R-HSA-9694548|reactome:R-HSA-975578|ensembl:ENST00000360689(transcript)|ensembl:ENST00000394586(transcript)|ensembl:ENST00000673929(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006491"(N-glycan processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008424"(glycoprotein 6-alpha-L-fucosyltransferase activity)|go:"GO:0009312"(oligosaccharide biosynthetic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0019082"(viral protein processing)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033578"(protein glycosylation in Golgi)|go:"GO:0036071"(N-glycan fucosylation)|go:"GO:0042355"(L-fucose catabolic process)|go:"GO:0043112"(receptor metabolic process)|go:"GO:0046368"(GDP-L-fucose metabolic process)|go:"GO:0046921"("alpha-(1->6)-fucosyltransferase activity") - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:4ExQD5i1NzMB4ZN+jMDAgEDfXmg9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q07864 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P55084 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P78347 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-359622|uniprotkb:Q75M88|uniprotkb:O14743|uniprotkb:O15359|uniprotkb:O43546|uniprotkb:O43588|uniprotkb:O43589|uniprotkb:Q9BSZ4|uniprotkb:Q86U51|uniprotkb:Q75M85|uniprotkb:Q75M86|uniprotkb:Q75M87|ensembl:ENSP00000460070 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:gtf2i_human(display_long)|uniprotkb:GTF2I(gene name)|psi-mi:GTF2I(display_short)|uniprotkb:BAP135(gene name synonym)|uniprotkb:WBSCR6(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)|uniprotkb:SRF-Phox1-interacting protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 6 protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001509.3|refseq:NP_127492.1|refseq:NP_127493.1|refseq:NP_127494.1|ensembl:ENSG00000263001(gene)|ensembl:ENST00000573035(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|mint:P78347|rcsb pdb:2D9B|rcsb pdb:2DN4|rcsb pdb:2ED2|rcsb pdb:2EJE|interpro:IPR036647|refseq:NP_001157108.1|refseq:NP_001267729.1|dip:DIP-24252N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:DqfrIS0Ey+XvZfTXmk9KQzBtQo49606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q6IAA8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O43759 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6269521|ensembl:ENSP00000332287|uniprotkb:A6NP69|uniprotkb:A8K0E2|uniprotkb:O43757|uniprotkb:O43758|uniprotkb:Q53Y02|uniprotkb:Q96J56|uniprotkb:Q9UGZ4 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:sng1_human(display_long)|uniprotkb:SYNGR1(gene name)|psi-mi:SYNGR1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000100321(gene)|ensembl:ENST00000328933(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR008253(Marvel)|interpro:IPR016579(Synaptogyrin)|mint:O43759|reactome:R-HSA-6798695|refseq:NP_004702.2|refseq:NP_663783.1|refseq:NP_663791.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:1wEiG09j29FhN8v7ZGSOvuK2Ong9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O00471 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-949824|ensembl:ENSP00000484855|uniprotkb:B2R6C5|intact:EBI-10171392|uniprotkb:Q8IW24 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:exoc5_human(display_long)|uniprotkb:Exocyst complex component Sec10(gene name synonym)|uniprotkb:EXOC5(gene name)|psi-mi:EXOC5(display_short)|uniprotkb:SEC10(gene name synonym)|uniprotkb:SEC10L1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000070367(gene)|ensembl:ENST00000621441(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904019"(epithelial cell apoptotic process)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR009976(Exocyst complex component Sec10)|interpro:IPR033960|mint:O00471|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:NP_006535.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:UaEk0DAH+boE9+hl8z3VUUI78dM9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9Y5Q8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1045409|uniprotkb:Q8N2U7|uniprotkb:Q8N857|uniprotkb:Q96GD9|uniprotkb:Q9H4P2|uniprotkb:A6NI44|uniprotkb:A6NJB9|uniprotkb:Q5T7U2|uniprotkb:Q5T7U3|intact:EBI-2556713|ensembl:ENSP00000361169 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:tf3c5_human(display_long)|uniprotkb:Transcription factor IIIC subunit epsilon(gene name synonym)|uniprotkb:TF3C-epsilon(gene name synonym)|uniprotkb:Transcription factor IIIC 63 kDa subunit(gene name synonym)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short)|uniprotkb:CDABP0017(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001116295.1|refseq:NP_036219.2|ensembl:ENSG00000148308(gene)|ensembl:ENST00000372097(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|mint:Q9Y5Q8|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|refseq:NP_001273638.1|dip:DIP-50823N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:Cb1wPs3qn4+Up/g7WgOMDEFtp+M9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O14949 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-720294|uniprotkb:Q5FVE2|uniprotkb:Q9BV88|uniprotkb:Q9T2V7|ensembl:ENSP00000367934|ensembl:ENSP00000367936|ensembl:ENSP00000367939 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:qcr8_human(display_long)|uniprotkb:Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C(gene name synonym)|uniprotkb:Ubiquinol-cytochrome c reductase complex 9.5 kDa protein(gene name synonym)|uniprotkb:Complex III subunit VIII(gene name synonym)|uniprotkb:Complex III subunit 8(gene name synonym)|uniprotkb:UQCRQ(gene name)|psi-mi:UQCRQ(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_055217.2|go:"GO:0021854"(hypothalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0030901"(midbrain development)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR004205(UcrQ)|interpro:IPR036642|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|ensembl:ENST00000378665(transcript)|ensembl:ENST00000378667(transcript)|ensembl:ENST00000378670(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0021539"(subthalamus development)|go:"GO:0021548"(pons development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|ensembl:ENSG00000164405(gene)|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:z3gRHzrSJVEiHxsbAKU0jHYkMIc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P10606 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1053725|uniprotkb:Q96J18|uniprotkb:Q99610|uniprotkb:Q53YB7|ensembl:ENSP00000258424 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox5b_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Vb(gene name synonym)|uniprotkb:COX5B(gene name)|psi-mi:COX5B(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001853.2|ensembl:ENSG00000135940(gene)|ensembl:ENST00000258424(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0046872"(metal ion binding)|interpro:IPR002124(Cytochrome c oxidase, subunit Vb)|interpro:IPR020893|interpro:IPR036972|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:EG8kMS2jKMWzQQokTXS2bYk4fHc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P61421 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-954063|ensembl:ENSP00000290949|uniprotkb:P12953|uniprotkb:Q02547 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:va0d1_human(display_long)|uniprotkb:Vacuolar proton pump subunit d 1(gene name synonym)|uniprotkb:V-ATPase AC39 subunit(gene name synonym)|uniprotkb:V-ATPase 40 kDa accessory protein(gene name synonym)|uniprotkb:32 kDa accessory protein(gene name synonym)|uniprotkb:ATP6V0D1(gene name)|psi-mi:ATP6V0D1(display_short)|uniprotkb:ATP6D(gene name synonym)|uniprotkb:VPATPD(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000159720(gene)|ensembl:ENST00000290949(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)|go:"GO:0033181"(plasma membrane proton-transporting V-type ATPase complex)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR002843(ATPase, V0/A0 complex, subunit C/D)|interpro:IPR016727(ATPase, V0 complex, subunit D)|interpro:IPR035067|interpro:IPR036079|interpro:IPR044911|mint:P61421|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-381038|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712|go:"GO:0016324"(apical plasma membrane)|refseq:NP_004682.2|dip:DIP-47435N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:3a/yIxEF9LMwAZUR3npGQrw8xNo9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9BW72 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2867844|ensembl:ENSP00000274787 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:hig2a_human(display_long)|uniprotkb:HIGD2A(gene name)|psi-mi:HIGD2A(display_short)|uniprotkb:RCF1 homolog B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_620175.1|ensembl:ENST00000274787(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070469"(respirasome)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR007667(Hypoxia induced protein conserved region)|ensembl:ENSG00000146066(gene) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:slz4YrTa7zG05TU7zobaVsWuNHg9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8IWV8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q99873 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P31930 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1052596|uniprotkb:Q96DD2|uniprotkb:B2R7R8|ensembl:ENSP00000203407 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:qcr1_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 1(gene name synonym)|uniprotkb:Complex III subunit 1(gene name synonym)|uniprotkb:UQCRC1(gene name)|psi-mi:UQCRC1(display_short)|uniprotkb:Core protein I(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_003356.2|ensembl:ENSG00000010256(gene)|ensembl:ENST00000203407(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0008121"(ubiquinol-cytochrome-c reductase activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0014823"(response to activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P31930|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:7Yrm6OhOmgfHF5mAX3hT3DMGnkc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q92896 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-359610|uniprotkb:Q6P9D1|uniprotkb:Q13221|uniprotkb:D3DUJ7|uniprotkb:B7Z8Y4|ensembl:ENSP00000405984 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:gslg1_human(display_long)|uniprotkb:GLG1(gene name)|psi-mi:GLG1(display_short)|uniprotkb:CFR1(gene name synonym)|uniprotkb:ESL1(gene name synonym)|uniprotkb:MG160(gene name synonym)|uniprotkb:Golgi sialoglycoprotein MG-160(gene name synonym)|uniprotkb:E-selectin ligand 1(gene name synonym)|uniprotkb:Cysteine-rich fibroblast growth factor receptor(gene name synonym)|uniprotkb:CFR-1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001139138.1|refseq:NP_001139139.1|refseq:NP_036333.2|ensembl:ENSG00000090863(gene)|ensembl:ENST00000422840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001893(Cysteine rich repeat)|interpro:IPR017873|interpro:IPR039728|reactome:R-HSA-202733|dip:DIP-27582N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:FTlNQD3o/wkPVjXkbB/G73BoBhw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P00395 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2117234|uniprotkb:Q34770|ensembl:ENSP00000354499 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox1_human(display_long)|uniprotkb:MT-CO1(gene name)|psi-mi:MT-CO1(display_short)|uniprotkb:COI(gene name synonym)|uniprotkb:COXI(gene name synonym)|uniprotkb:MTCO1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide I(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:YP_003024028.1|ensembl:ENSG00000198804(gene)|ensembl:ENST00000361624(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007568"(aging)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0020037"(heme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045277"(respiratory chain complex IV)|go:"GO:0046688"(response to copper ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051602"(response to electrical stimulus)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR033944|interpro:IPR036927|mint:P00395|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:hPHsY8UxxIWcLFkR9oIoZH5vtls9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8IZT6 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1057621|uniprotkb:Q4G1H1|uniprotkb:Q86UX4|uniprotkb:Q8IUL2|uniprotkb:Q8IZJ7|uniprotkb:Q8IZJ8|uniprotkb:Q8IZJ9|uniprotkb:Q8N4D1|uniprotkb:Q9NVS1|uniprotkb:Q9NVT6|uniprotkb:Q5VYL3|ensembl:ENSP00000356379 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:aspm_human(display_long)|uniprotkb:ASPM(gene name)|psi-mi:ASPM(display_short)|uniprotkb:MCPH5(gene name synonym)|uniprotkb:Abnormal spindle protein homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001193775.1|refseq:NP_060606.3|go:"GO:0048477"(oogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0051445"(regulation of meiotic cell cycle)|go:"GO:0051653"(spindle localization)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090306"(meiotic spindle assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027417|interpro:IPR029955|interpro:IPR031549|interpro:IPR036872|go:"GO:0045769"(negative regulation of asymmetric cell division)|ensembl:ENSG00000066279(gene)|ensembl:ENST00000367409(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007051"(spindle organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021873"(forebrain neuroblast division)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030496"(midbody)|go:"GO:0036449"(microtubule minus-end)|go:"GO:0045665"(negative regulation of neuron differentiation) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:DQbMaRaMAJI7beVJKAmBgsXgeCo9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P14406 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2606666|uniprotkb:Q5TF59|uniprotkb:Q6FGI2|uniprotkb:Q3MIH5|uniprotkb:B2R5E1|ensembl:ENSP00000506727 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cx7a2_human(display_long)|uniprotkb:COX7AL(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIIa-liver/heart(gene name synonym)|uniprotkb:COX7A2(gene name)|psi-mi:COX7A2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001856.2|ensembl:ENSG00000112695(gene)|ensembl:ENST00000684430(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR036539|interpro:IPR039297|mint:P14406|rcsb pdb:5Z62 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:krjTK658npBV4G6gH28GJhVqBkY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9Y2R0 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6570446|uniprotkb:A8K498|ensembl:ENSP00000354762 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:coa3_human(display_long)|uniprotkb:COA3(gene name)|psi-mi:COA3(display_short)|uniprotkb:CCDC56(gene name synonym)|uniprotkb:MITRAC12(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)|uniprotkb:Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa(gene name synonym)|uniprotkb:HSPC009(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001035521.1|ensembl:ENSG00000183978(gene)|ensembl:ENST00000328434(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:xDKgvGxvOS7YMkleFm3VAQgfcOU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q12789 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-357956|uniprotkb:B2RP21|uniprotkb:Q12838|uniprotkb:Q6DKN9|uniprotkb:Q9Y4W9|ensembl:ENSP00000348510 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:tf3c1_human(display_long)|uniprotkb:GTF3C1(gene name)|psi-mi:GTF3C1(display_short)|uniprotkb:Transcription factor IIIC subunit alpha(gene name synonym)|uniprotkb:TF3C-alpha(gene name synonym)|uniprotkb:Transcription factor IIIC 220 kDa subunit(gene name synonym)|uniprotkb:TFIIIC box B-binding subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001511.2|refseq:NP_001273171.1|dip:DIP-38212N|ensembl:ENSG00000077235(gene)|ensembl:ENST00000356183(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009304"(tRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007309(B-block binding subunit of TFIIIC)|interpro:IPR035625|interpro:IPR044210|mint:Q12789|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:1celgxr5g9oKbPr0x1SvI6S7hNE9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96QD8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-723083|uniprotkb:Q6ZMG2|uniprotkb:Q9HAV3|uniprotkb:Q9NVA8|uniprotkb:Q9P2G5|uniprotkb:Q6IA88|ensembl:ENSP00000256689 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:s38a2_human(display_long)|uniprotkb:ATA2(gene name synonym)|uniprotkb:KIAA1382(gene name synonym)|uniprotkb:SAT2(gene name synonym)|uniprotkb:SNAT2(gene name synonym)|uniprotkb:Amino acid transporter A2(gene name synonym)|uniprotkb:System A amino acid transporter 2(gene name synonym)|uniprotkb:System N amino acid transporter 2(gene name synonym)|uniprotkb:System A transporter 1(gene name synonym)|uniprotkb:Solute carrier family 38 member 2(gene name synonym)|uniprotkb:Protein 40-9-1(gene name synonym)|uniprotkb:SLC38A2(gene name)|psi-mi:SLC38A2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_061849.2|go:"GO:0030425"(dendrite)|go:"GO:0031460"(glycine betaine transport)|go:"GO:0032328"(alanine transport)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903841"("cellular response to arsenite(3-)")|interpro:IPR013057(Amino acid transporter, transmembrane)|reactome:R-HSA-210500|reactome:R-HSA-352230|go:"GO:0030424"(axon)|ensembl:ENSG00000134294(gene)|ensembl:ENST00000256689(transcript)|go:"GO:0003333"(amino acid transmembrane transport)|go:"GO:0005295"("neutral amino acid:sodium symporter activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0007565"(female pregnancy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0015825"(L-serine transport)|go:"GO:0021987"(cerebral cortex development)|refseq:NP_001294865.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:2L7TtYR3hQkSrpC/Ig4ODtgCad09606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O95260 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1043378|uniprotkb:O95261|uniprotkb:Q8WW04|ensembl:ENSP00000224652|uniprotkb:Q5SQQ3 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ate1_human(display_long)|uniprotkb:Arginine-tRNA--protein transferase 1(gene name synonym)|uniprotkb:ATE1(gene name)|psi-mi:ATE1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000107669(gene)|ensembl:ENST00000224652(transcript)|interpro:IPR007471(Arginine-tRNA-protein transferase, N-terminal)|interpro:IPR007472(Arginine-tRNA-protein transferase, C-terminal)|go:"GO:0004057"(arginyltransferase activity)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017137(Arginine-tRNA--protein transferase 1, eukaryotic)|go:"GO:0005634"(nucleus)|interpro:IPR030700|mint:O95260|go:"GO:0005737"(cytoplasm)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016598"(protein arginylation)|refseq:NP_001001976.1|refseq:NP_008972.2|refseq:NP_001275663.1|refseq:NP_001275664.1|refseq:NP_001275665.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:vK21nNxx2fa9ct7O5WG0LqtD9u09606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P13073 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8WUA4 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1237062|uniprotkb:D6W557|ensembl:ENSP00000264720|ensembl:ENSP00000352536|uniprotkb:Q16632|uniprotkb:Q9BWI7 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:tf3c2_human(display_long)|uniprotkb:GTF3C2(gene name)|psi-mi:GTF3C2(display_short)|uniprotkb:KIAA0011(gene name synonym)|uniprotkb:Transcription factor IIIC subunit beta(gene name synonym)|uniprotkb:TF3C-beta(gene name synonym)|uniprotkb:Transcription factor IIIC 110 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000115207(gene)|ensembl:ENST00000264720(transcript)|ensembl:ENST00000359541(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q8WUA4|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|refseq:NP_001030598.1|refseq:NP_001512.1|refseq:NP_001305838.1|dip:DIP-38213N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:D2SnUgtDMoh8axZsIMskwjmNW1c9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9UBU6 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6309101|intact:EBI-28967558|ensembl:ENSP00000259963|uniprotkb:B2R725 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:fa8a1_human(display_long)|uniprotkb:FAM8A1(gene name)|psi-mi:FAM8A1(display_short)|uniprotkb:AHCP(gene name synonym)|uniprotkb:Autosomal highly conserved protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSP00000259963|ensembl:ENSG00000137414(gene)|ensembl:ENST00000259963(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|interpro:IPR010432(RDD)|interpro:IPR039871|refseq:NP_057339.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:0HV6qye10bMGdnt9CiGztIacrHM9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9UKN8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1237240|uniprotkb:Q5VZJ7|ensembl:ENSP00000361219 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:tf3c4_human(display_long)|uniprotkb:GTF3C4(gene name)|psi-mi:GTF3C4(display_short)|uniprotkb:Transcription factor IIIC subunit delta(gene name synonym)|uniprotkb:TF3C-delta(gene name synonym)|uniprotkb:Transcription factor IIIC 90 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_036336.2|ensembl:ENSG00000125484(gene)|ensembl:ENST00000372146(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0042791"(5S class rRNA transcription by RNA polymerase III)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR024761|interpro:IPR024764|interpro:IPR036322|interpro:IPR044230|mint:Q9UKN8|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:OFldz80WMs7KQ59Of0rkkj80lyc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O95470 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1046170|uniprotkb:Q7Z732|uniprotkb:Q9ULG8|uniprotkb:Q9UN89|uniprotkb:B2RBD4|ensembl:ENSP00000362298 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:sgpl1_human(display_long)|uniprotkb:Sphingosine-1-phosphate aldolase(gene name synonym)|uniprotkb:SGPL1(gene name)|psi-mi:SGPL1(display_short)|uniprotkb:KIAA1252(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_003892.2|refseq:XP_011538618.1|refseq:XP_011538619.1|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|ensembl:ENSG00000166224(gene)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENST00000373202(transcript)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|go:"GO:0001553"(luteinization)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008117"(sphinganine-1-phosphate aldolase activity)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:4Q6R|reactome:R-HSA-1660661|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|refseq:XP_005270320.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:hGut7nnomGA7QJhsV4lHBNm+kEE9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9BZF1 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2684038|uniprotkb:Q52LQ3|uniprotkb:Q9P277|uniprotkb:Q8WXP8|uniprotkb:A8K1T2|uniprotkb:E9PE66|uniprotkb:E9PE68|uniprotkb:Q68D75|ensembl:ENSP00000261183 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:osbl8_human(display_long)|uniprotkb:KIAA1451(gene name synonym)|uniprotkb:ORP8(gene name synonym)|uniprotkb:OSBP10(gene name synonym)|uniprotkb:OSBPL8(gene name)|psi-mi:OSBPL8(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001003712.1|refseq:NP_065892.1|refseq:NP_001306581.1|refseq:NP_001306584.1|ensembl:ENSG00000091039(gene)|ensembl:ENST00000261183(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0140343"(phosphatidylserine transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BZF1|rcsb pdb:1V88|rcsb pdb:5U77|rcsb pdb:5U78|reactome:R-HSA-1482801|refseq:XP_005268678.1|refseq:XP_006719287.1|dip:DIP-56130N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:KwZ5DFeGTIM3p/yP3XBNgr/v3O09606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8NB49 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-11279131|uniprotkb:Q5JT69|uniprotkb:Q5JT70|uniprotkb:Q5JT71|uniprotkb:Q5JT72|uniprotkb:Q5JT73|uniprotkb:Q6ZND5|uniprotkb:Q6ZU50|uniprotkb:Q6ZUP7|uniprotkb:Q70IJ9|uniprotkb:Q70IK0|uniprotkb:Q8WX24|ensembl:ENSP00000332756 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:at11c_human(display_long)|uniprotkb:ATP11C(gene name)|psi-mi:ATP11C(display_short)|uniprotkb:ATPIG(gene name synonym)|uniprotkb:ATPIQ(gene name synonym)|uniprotkb:ATPase IQ(gene name synonym)|uniprotkb:ATPase class VI type 11C(gene name synonym)|uniprotkb:P4-ATPase flippase complex alpha subunit ATP11C(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001010986.1|refseq:NP_775965.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0090555"(phosphatidylethanolamine flippase activity)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:0140346"(phosphatidylserine flippase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR006539(Phospholipid-translocating P-type ATPase, flippase)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030363|interpro:IPR032630|interpro:IPR032631|interpro:IPR036412|interpro:IPR044492|rcsb pdb:6LKN|rcsb pdb:7BSP|rcsb pdb:7BSQ|rcsb pdb:7BSS|rcsb pdb:7BSU|rcsb pdb:7BSV|rcsb pdb:7BSW|reactome:R-HSA-936837|ensembl:ENSG00000101974(gene)|ensembl:ENST00000327569(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:U7oKi+71kYBQFF3+M1CePoEnXx09606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9ULF5 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2823223|uniprotkb:B4DGU0|uniprotkb:A8K5C6|uniprotkb:Q3MJA4|uniprotkb:Q6DKH6|uniprotkb:Q68CR5|uniprotkb:Q9Y3Z1|ensembl:ENSP00000352655|ensembl:ENSP00000386766 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:s39aa_human(display_long)|uniprotkb:SLC39A10(gene name)|psi-mi:SLC39A10(display_short)|uniprotkb:KIAA1265(gene name synonym)|uniprotkb:ZIP10(gene name synonym)|uniprotkb:Solute carrier family 39 member 10(gene name synonym)|uniprotkb:Zrt- and Irt-like protein 10(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:XP_011509806.1|refseq:XP_011509807.1|refseq:XP_011509808.1|refseq:XP_005246746.2|refseq:NP_001120729.1|refseq:NP_065075.1|ensembl:ENSG00000196950(gene)|ensembl:ENST00000359634(transcript)|ensembl:ENST00000409086(transcript)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0071578"(zinc ion import across plasma membrane)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|interpro:IPR003689(Zinc/iron permease)|reactome:R-HSA-442380 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:j7A/tPe/lJCOscfBZhF1mSe99k09606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P35610 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6621955|ensembl:ENSP00000356591|uniprotkb:A6NC40|uniprotkb:A8K3P4|uniprotkb:A9Z1V7|uniprotkb:B4DU95|uniprotkb:Q5T0X4|uniprotkb:Q8N1E4 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:soat1_human(display_long)|uniprotkb:SOAT1(gene name)|psi-mi:SOAT1(display_short)|uniprotkb:ACACT(gene name synonym)|uniprotkb:ACACT1(gene name synonym)|uniprotkb:ACAT(gene name synonym)|uniprotkb:ACAT1(gene name synonym)|uniprotkb:SOAT(gene name synonym)|uniprotkb:STAT(gene name synonym)|uniprotkb:"Acyl-coenzyme A:cholesterol acyltransferase 1"(gene name synonym)|uniprotkb:Cholesterol acyltransferase 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) go:"GO:0010878"(cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0034736"(cholesterol O-acyltransferase activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|ensembl:ENSG00000057252(gene)|interpro:IPR014371(Sterol O-acyltransferase, ACAT/DAG/ARE types)|interpro:IPR030687|mint:P35610|rcsb pdb:6L47|rcsb pdb:6L48|rcsb pdb:6P2J|rcsb pdb:6P2P|rcsb pdb:6VUM|reactome:R-HSA-8964038|ensembl:ENST00000367619(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004772"(sterol O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010742"(macrophage derived foam cell differentiation)|refseq:XP_011508213.1|refseq:NP_001239440.1|refseq:NP_001239441.1|refseq:NP_003092.4 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:jX8d8x9ZYOdpE2Vg+C5ECuX9zQQ9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9Y6M9 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-713654|uniprotkb:Q9UQE8|uniprotkb:B2R8M6|ensembl:ENSP00000276689|ensembl:ENSP00000504235 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ndub9_human(display_long)|uniprotkb:LYRM3(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase B22 subunit(gene name synonym)|uniprotkb:Complex I-B22(gene name synonym)|uniprotkb:LYR motif-containing protein 3(gene name synonym)|uniprotkb:NDUFB9(gene name)|psi-mi:NDUFB9(display_short)|uniprotkb:UQOR22(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) rcsb pdb:5XTH|rcsb pdb:5XTD|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000147684(gene)|ensembl:ENST00000276689(transcript)|ensembl:ENST00000677021(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008011(Complex 1 LYR protein)|interpro:IPR033034|mint:Q9Y6M9|rcsb pdb:5XTC|refseq:NP_001298097.1|refseq:NP_004996.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:sNQcYhIFMHZA5T6MeeiwAeAJ5Gs9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8N1B4 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O96000 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q93050 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2891238|ensembl:ENSP00000342951|uniprotkb:Q8N5G7|uniprotkb:Q9NSX0|intact:EBI-4324496|uniprotkb:B7Z3B7 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:vpp1_human(display_long)|uniprotkb:ATP6V0A1(gene name)|psi-mi:ATP6V0A1(display_short)|uniprotkb:ATP6N1(gene name synonym)|uniprotkb:ATP6N1A(gene name synonym)|uniprotkb:VPP1(gene name synonym)|uniprotkb:Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1(gene name synonym)|uniprotkb:Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit(gene name synonym)|uniprotkb:Vacuolar proton pump subunit 1(gene name synonym)|uniprotkb:Vacuolar adenosine triphosphatase subunit Ac116(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000033627(gene)|ensembl:ENST00000343619(transcript)|go:"GO:0000220"(vacuolar proton-transporting V-type ATPase, V0 domain)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901998"(toxin transport)|interpro:IPR002490(ATPase, V0/A0 complex, 116-kDa subunit)|mint:Q93050|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-6798695|reactome:R-HSA-77387|interpro:IPR026028|reactome:R-HSA-917977|reactome:R-HSA-983712|refseq:NP_001123492.1|refseq:NP_001123493.1|refseq:NP_005168.2 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:3htDhXCA9potj7i32HoA2j3Sfqw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q86YS7 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1051086|uniprotkb:Q17RY7|uniprotkb:O60280|uniprotkb:Q7Z619|uniprotkb:Q86SU3|uniprotkb:B4DRN7|uniprotkb:B4DJ03|uniprotkb:B7ZLL0|uniprotkb:F5H2A1|uniprotkb:F5H5R1|ensembl:ENSP00000334229 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:c2cd5_human(display_long)|uniprotkb:C2CD5(gene name)|psi-mi:C2CD5(display_short)|uniprotkb:C2 domain-containing phosphoprotein of 138 kDa(gene name synonym)|uniprotkb:CDP138(gene name synonym)|uniprotkb:KIAA0528(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001273102.1|refseq:NP_001273103.1|refseq:NP_001273104.1|refseq:NP_001273105.1|refseq:NP_001273106.1|refseq:NP_055617.1|ensembl:ENSG00000111731(gene)|ensembl:ENST00000333957(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR035892|interpro:IPR037785|interpro:IPR038983|reactome:R-HSA-1445148 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:gfc4mjq83/Mu1V+v0w/S5BCuocA9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9BRQ6 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2557895|ensembl:ENSP00000290913|uniprotkb:D6R9U0|uniprotkb:D6RIB4|uniprotkb:H8Y0Y7 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:mic25_human(display_long)|uniprotkb:CHCHD6(gene name)|psi-mi:CHCHD6(display_short)|uniprotkb:CHCM1(gene name synonym)|uniprotkb:Coiled-coil-helix cristae morphology protein 1(gene name synonym)|uniprotkb:Coiled-coil-helix-coiled-coil-helix domain-containing protein 6(gene name synonym)|uniprotkb:MIC25(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_115719.1|refseq:NP_001307539.1|ensembl:ENSG00000159685(gene)|ensembl:ENST00000290913(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0042407"(cristae formation)|go:"GO:0061617"(MICOS complex)|go:"GO:0140275"(MIB complex)|interpro:IPR042860|mint:Q9BRQ6|reactome:R-HSA-8949613 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:6jrzreYX6MJWPfMKh2EKqiEca1s9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O95167 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1246131|ensembl:ENSP00000398290|ensembl:ENSP00000418438|ensembl:ENSP00000477783|ensembl:ENSP00000477919|ensembl:ENSP00000478119|ensembl:ENSP00000480437|ensembl:ENSP00000481545|ensembl:ENSP00000482015|ensembl:ENSP00000483002|ensembl:ENSP00000483683|ensembl:ENSP00000483934|ensembl:ENSP00000484436 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ndua3_human(display_long)|uniprotkb:NDUFA3(gene name)|psi-mi:NDUFA3(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B9 subunit(gene name synonym)|uniprotkb:Complex I-B9(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004533.1|refseq:XP_016882322.1|ensembl:ENSG00000170906(gene)|ensembl:ENSG00000273642(gene)|ensembl:ENSG00000274359(gene)|ensembl:ENSG00000275605(gene)|ensembl:ENSG00000275724(gene)|ensembl:ENSG00000276061(gene)|ensembl:ENSG00000276220(gene)|ensembl:ENSG00000276766(gene)|ensembl:ENSG00000277722(gene)|ensembl:ENSG00000278365(gene)|ensembl:ENST00000419113(transcript)|ensembl:ENST00000485876(transcript)|ensembl:ENST00000610406(transcript)|ensembl:ENST00000612327(transcript)|ensembl:ENST00000617282(transcript)|ensembl:ENST00000618338(transcript)|ensembl:ENST00000619253(transcript)|ensembl:ENST00000619966(transcript)|ensembl:ENST00000620289(transcript)|ensembl:ENST00000621307(transcript)|ensembl:ENST00000622523(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR026626|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENST00000613276(transcript) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:12DLltKnKM9F+jax3k6NKJu+suQ9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O43920 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1246091|ensembl:ENSP00000362058|ensembl:ENSP00000362060 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ndus5_human(display_long)|uniprotkb:NDUFS5(gene name)|psi-mi:NDUFS5(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 15 kDa subunit(gene name synonym)|uniprotkb:Complex I-15 kDa(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001171908.1|refseq:NP_004543.1|ensembl:ENSG00000168653(gene)|ensembl:ENST00000372967(transcript)|ensembl:ENST00000372969(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR019342|mint:O43920|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:q74OuEXKdyCuxrUujwHeZjkW2gY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P11233 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1036803|uniprotkb:A4D1W3|ensembl:ENSP00000005257 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:rala_human(display_long)|uniprotkb:RAL(gene name synonym)|uniprotkb:RALA(gene name)|psi-mi:RALA(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_005393.2|refseq:XP_006715825.1|go:"GO:0019003"(GDP binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051665"(membrane raft localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090543"(Flemming body)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR028412|rcsb pdb:1UAD|rcsb pdb:1ZC3|rcsb pdb:1ZC4|rcsb pdb:2A78|mint:P11233|rcsb pdb:2A9K|rcsb pdb:2BOV|rcsb pdb:6P0I|rcsb pdb:6P0J|rcsb pdb:6P0K|rcsb pdb:6P0L|rcsb pdb:6P0M|rcsb pdb:6P0N|rcsb pdb:6P0O|reactome:R-HSA-1445148|reactome:R-HSA-171007|reactome:R-HSA-8950505|ensembl:ENSG00000006451(gene)|ensembl:ENST00000005257(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0017022"(myosin binding)|go:"GO:0017157"(regulation of exocytosis)|refseq:XP_011513768.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:41WF1UoYnYZvwC0OPpYwCEqIg2E9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P49821 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-748312|uniprotkb:Q6IBR3|uniprotkb:O60924|uniprotkb:O60940|uniprotkb:Q16104|uniprotkb:Q96BF8|uniprotkb:Q96HS7|ensembl:ENSP00000322450|ensembl:ENSP00000497587 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:nduv1_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 51 kDa subunit(gene name synonym)|uniprotkb:Complex I-51kD(gene name synonym)|uniprotkb:NADH dehydrogenase flavoprotein 1(gene name synonym)|uniprotkb:NDUFV1(gene name)|psi-mi:NDUFV1(display_short)|uniprotkb:UQOR1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001159574.1|refseq:NP_009034.2|ensembl:ENSG00000167792(gene)|ensembl:ENST00000322776(transcript)|ensembl:ENST00000647561(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0010181"(FMN binding)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001949(NADH-ubiquinone oxidoreductase, 51 kDa subunit, conserved site)|interpro:IPR011537(NADH-ubiquinone oxidoreductase, F subunit)|interpro:IPR011538(NADH-ubiquinone oxidoreductase, 51 kDa subunit)|interpro:IPR019554|interpro:IPR019575|interpro:IPR037207|interpro:IPR037225|mint:P49821|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:0pEd6isDBEamZQJ5QNo5yJ7rKu89606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O95169 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-716238|uniprotkb:Q5W144|uniprotkb:Q9UG53|uniprotkb:Q9UJR4|uniprotkb:Q9UQF3|uniprotkb:A8K0L4|intact:EBI-11021395|uniprotkb:Q5W143|uniprotkb:Q5W145|intact:EBI-28971189|ensembl:ENSP00000299166 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:ndub8_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase ASHI subunit(gene name synonym)|uniprotkb:Complex I-ASHI(gene name synonym)|uniprotkb:NDUFB8(gene name)|psi-mi:NDUFB8(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSP00000299166|ensembl:ENST00000370320|ensembl:ENSP00000359344|ensembl:ENST00000370322|ensembl:ENSP00000359346|refseq:NP_004995.1|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-1268020|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR008699(NADH-ubiquinone oxidoreductase ASHI subunit)|interpro:IPR016551("NADH dehydrogenase [ubiquinone] (complex I), beta subcomplex, subunit 8")|rcsb pdb:5XTC|rcsb pdb:5XTD|ensembl:ENSG00000166136(gene)|ensembl:ENST00000299166(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|refseq:NP_001271296.1|refseq:NP_001271297.1 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:iHF93OOQynl/ZBrUOOp9sAbDZkw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P09669 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-715040|uniprotkb:B2R4D7|ensembl:ENSP00000297564|ensembl:ENSP00000428150|ensembl:ENSP00000428702|ensembl:ENSP00000428895|ensembl:ENSP00000428965|ensembl:ENSP00000429410|ensembl:ENSP00000429707|ensembl:ENSP00000429714|ensembl:ENSP00000429755|ensembl:ENSP00000429991 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox6c_human(display_long)|uniprotkb:COX6C(gene name)|psi-mi:COX6C(display_short)|uniprotkb:Cytochrome c oxidase polypeptide VIc(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004365.1|refseq:XP_016868509.1|ensembl:ENSG00000164919(gene)|ensembl:ENST00000297564(transcript)|ensembl:ENST00000517682(transcript)|ensembl:ENST00000518171(transcript)|ensembl:ENST00000520271(transcript)|ensembl:ENST00000520468(transcript)|ensembl:ENST00000520517(transcript)|ensembl:ENST00000522934(transcript)|ensembl:ENST00000522940(transcript)|ensembl:ENST00000523016(transcript)|ensembl:ENST00000524245(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004204(Cytochrome c oxidase subunit VIc)|interpro:IPR034884|interpro:IPR037169|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0006091"(generation of precursor metabolites and energy) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:Zha4dqasvkWw3ACebJNflgxCVKo9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q86TM6 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-947849|uniprotkb:Q8N3K3|uniprotkb:Q8N6E8|uniprotkb:Q96JL5|uniprotkb:Q96PK3|ensembl:ENSP00000366395 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:syvn1_human(display_long)|uniprotkb:Synovial apoptosis inhibitor 1(gene name synonym)|uniprotkb:SYVN1(gene name)|psi-mi:SYVN1(display_short)|uniprotkb:HRD1(gene name synonym)|uniprotkb:KIAA1810(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase synoviolin(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_115807.1|refseq:NP_757385.1|refseq:XP_011543605.1|dip:DIP-43982N|ensembl:ENSG00000162298(gene)|ensembl:ENST00000377190(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR032832|mint:Q86TM6|rcsb pdb:6A3Z|reactome:R-HSA-381038|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-901032 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:O4/BJg+TtC9t/YmKWsf4FrSW8yo9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9Y512 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-748409|uniprotkb:Q969Y9|uniprotkb:Q96I46|uniprotkb:Q9NW85|uniprotkb:Q9UQM9|ensembl:ENSP00000345445|uniprotkb:Q53HC4|uniprotkb:Q56VW7 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:sam50_human(display_long)|uniprotkb:SAMM50(gene name)|psi-mi:SAMM50(display_short)|uniprotkb:CGI-51(orf name)|uniprotkb:Transformation-related gene 3 protein(gene name synonym)|uniprotkb:TRG3(orf name)|uniprotkb:SAM50(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000100347(gene)|refseq:NP_056195.3|ensembl:ENST00000350028(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033108"(mitochondrial respiratory chain complex assembly)|go:"GO:0034622"|go:"GO:0042407"(cristae formation)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140275"(MIB complex)|interpro:IPR000184("Bacterial surface antigen (D15)")|interpro:IPR034746|interpro:IPR039910|mint:Q9Y512|rcsb pdb:6YOO|rcsb pdb:6YOP|reactome:R-HSA-1268020|reactome:R-HSA-8949613|reactome:R-HSA-9013404 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:wpqEL4ia/LUNdXSlQBRZxPfwCcY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96N66 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-6116499|ensembl:ENSP00000245615|ensembl:ENSP00000478041|ensembl:ENSP00000478088|ensembl:ENSP00000478965|ensembl:ENSP00000481455|ensembl:ENSP00000482252|ensembl:ENSP00000482625|ensembl:ENSP00000484199|ensembl:ENSP00000484933|ensembl:ENSP00000484954|uniprotkb:A9C4B6|uniprotkb:B0V3I5|uniprotkb:B4DQ87|uniprotkb:Q05DF0|uniprotkb:Q7L5N2|uniprotkb:Q99908|uniprotkb:Q9BPV2|uniprotkb:Q9BRE9 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:mboa7_human(display_long)|uniprotkb:MBOAT7(gene name)|psi-mi:MBOAT7(display_short)|uniprotkb:BB1(gene name synonym)|uniprotkb:LENG4(gene name synonym)|uniprotkb:OACT7(gene name synonym)|uniprotkb:1-acylglycerophosphatidylinositol O-acyltransferase(gene name synonym)|uniprotkb:Bladder and breast carcinoma-overexpressed gene 1 protein(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 4(gene name synonym)|uniprotkb:Lysophosphatidylinositol acyltransferase(gene name synonym)|uniprotkb:Membrane-bound O-acyltransferase domain-containing protein 7(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:XP_011525601.1|refseq:XP_011525602.1|ensembl:ENSG00000125505(gene)|ensembl:ENSG00000273592(gene)|ensembl:ENSG00000274194(gene)|ensembl:ENSG00000275118(gene)|ensembl:ENSG00000276935(gene)|ensembl:ENSG00000277025(gene)|ensembl:ENSG00000277733(gene)|ensembl:ENSG00000277923(gene)|ensembl:ENSG00000278322(gene)|ensembl:ENSG00000278519(gene)|refseq:NP_001139528.1|refseq:NP_001139554.1|refseq:NP_001139555.1|refseq:NP_077274.3|ensembl:ENST00000245615(transcript)|ensembl:ENST00000613506(transcript)|ensembl:ENST00000613746(transcript)|ensembl:ENST00000615453(transcript)|ensembl:ENST00000617012(transcript)|ensembl:ENST00000618378(transcript)|ensembl:ENST00000619842(transcript)|ensembl:ENST00000619855(transcript)|ensembl:ENST00000621612(transcript)|ensembl:ENST00000621875(transcript)|go:"GO:0003841"(1-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0021591"(ventricular system development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030258"(lipid modification)|go:"GO:0036149"(phosphatidylinositol acyl-chain remodeling)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0047144"(2-acylglycerol-3-phosphate O-acyltransferase activity)|go:"GO:0071617"(lysophospholipid acyltransferase activity)|go:"GO:0090207"(regulation of triglyceride metabolic process)|interpro:IPR004299(Membrane bound O-acyl transferase, MBOAT)|mint:Q96N66|reactome:R-HSA-1482922 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:NdxbWV63CtA/flzPPhYadlBQksU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9ULK5 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1054279|uniprotkb:Q5T212|uniprotkb:D3DVE9|ensembl:ENSP00000357040 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:vang2_human(display_long)|uniprotkb:Van Gogh-like protein 2(gene name synonym)|uniprotkb:Strabismus 1(gene name synonym)|uniprotkb:Loop-tail protein 1 homolog(gene name synonym)|uniprotkb:VANGL2(gene name)|psi-mi:VANGL2(display_short)|uniprotkb:KIAA1215(gene name synonym)|uniprotkb:STB1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_065068.1|refseq:XP_011508106.1|refseq:XP_005245414.1|ensembl:ENSG00000162738(gene)|ensembl:ENST00000368061(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0035787"(cell migration involved in kidney development)|go:"GO:0045176"(apical protein localization)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR009539(Strabismus)|mint:Q9ULK5|rcsb pdb:6XA6|rcsb pdb:6XA7|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:x6JAZMeK90S/m6+oSp/W1tN1Cjc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O14548 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-743578|uniprotkb:Q9P118|ensembl:ENSP00000234301|ensembl:ENSP00000367938 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox7r_human(display_long)|uniprotkb:Cytochrome c oxidase subunit VIIa-related protein(gene name synonym)|uniprotkb:COX7a-related protein(gene name synonym)|uniprotkb:EB1(gene name synonym)|uniprotkb:COX7RP(gene name synonym)|uniprotkb:COX7A2L(gene name)|psi-mi:COX7A2L(display_short)|uniprotkb:COX7AR(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004709.2|refseq:NP_001305965.1|refseq:NP_001305969.1|ensembl:ENSG00000115944(gene)|ensembl:ENST00000234301(transcript)|ensembl:ENST00000378669(transcript)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR003177(Cytochrome c oxidase, subunit VIIa)|interpro:IPR017267(Cytochrome c oxidase subunit VIIa-related, mitochondrial)|interpro:IPR036539|interpro:IPR039297|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:qJHxwSXSwyenuqJmKPhQ3R76aqE9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q96KP1 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-465715|uniprotkb:Q5JPC8|uniprotkb:Q96AN6|uniprotkb:Q9NUZ8|uniprotkb:Q9UJM7|ensembl:ENSP00000230449|uniprotkb:B2RBE6 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:exoc2_human(display_long)|uniprotkb:EXOC2(gene name)|psi-mi:EXOC2(display_short)|uniprotkb:SEC5(gene name synonym)|uniprotkb:SEC5L1(gene name synonym)|uniprotkb:Exocyst complex component Sec5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000112685(gene)|ensembl:ENST00000230449(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0090543"(Flemming body)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR029175|interpro:IPR039481|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016866507.1|refseq:XP_016866508.1|refseq:XP_016866509.1|refseq:XP_016866510.1|refseq:XP_016866511.1|refseq:XP_016866512.1|refseq:XP_016866513.1|refseq:NP_060773.3|dip:DIP-31795N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:7p+4vZ18z6u2PJY0GzbHY+ro0v89606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9NV70 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-1045313|uniprotkb:Q504V4|uniprotkb:Q8WUE7|uniprotkb:Q96T15|uniprotkb:Q9NZE4|ensembl:ENSP00000326514|ensembl:ENSP00000370695 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:exoc1_human(display_long)|uniprotkb:Exocyst complex component Sec3(gene name synonym)|uniprotkb:EXOC1(gene name)|psi-mi:EXOC1(display_short)|uniprotkb:SEC3(gene name synonym)|uniprotkb:SEC3L1(gene name synonym)|uniprotkb:BM-012(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001020095.1|refseq:NP_060731.2|refseq:NP_839955.1|ensembl:ENSG00000090989(gene)|ensembl:ENST00000346134(transcript)|ensembl:ENST00000381295(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051607"(defense response to virus)|go:"GO:0090543"(Flemming body)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|interpro:IPR019160|interpro:IPR028258|mint:Q9NV70|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|refseq:XP_016863898.1|dip:DIP-37579N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:DKEfnn4CJkBSIdGRfVy+znSPOrc9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q6ZPD9 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2871931|uniprotkb:Q68DC7|uniprotkb:Q6ZTS2|uniprotkb:Q6ZTB7|ensembl:ENSP00000376081|ensembl:ENSP00000344937 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:d19l3_human(display_long)|uniprotkb:DPY19L3(gene name)|psi-mi:DPY19L3(display_short)|uniprotkb:Dpy-19-like protein 3(gene name synonym)|uniprotkb:Protein dpy-19 homolog 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:XP_011524828.1|refseq:NP_001166245.1|refseq:NP_997208.2|ensembl:ENST00000342179(transcript)|ensembl:ENST00000392250(transcript)|go:"GO:0000030"(mannosyltransferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018406"(protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan)|interpro:IPR018732|interpro:IPR030039|ensembl:ENSG00000178904(gene) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:N+hLBwy/nP3zdNXbr/GXW3V8AqI9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P15954 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2606678|uniprotkb:Q6NR81|ensembl:ENSP00000247655|ensembl:ENSP00000425759 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox7c_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide VIIc(gene name synonym)|uniprotkb:COX7C(gene name)|psi-mi:COX7C(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001858.1|ensembl:ENST00000247655(transcript)|ensembl:ENST00000509578(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004202(Cytochrome c oxidase subunit VIIc)|interpro:IPR036636|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|ensembl:ENSG00000127184(gene) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:hBYR7f5I8aE5H8JreIvHF8tg1HU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8TAA9 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-682393|uniprotkb:Q86WG8|uniprotkb:Q8N559|uniprotkb:Q5T1D3|uniprotkb:Q5T1D4|ensembl:ENSP00000310800|ensembl:ENSP00000347672|ensembl:ENSP00000358522 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:vang1_human(display_long)|uniprotkb:Van Gogh-like protein 1(gene name synonym)|uniprotkb:Strabismus 2(gene name synonym)|uniprotkb:Loop-tail protein 2 homolog(gene name synonym)|uniprotkb:VANGL1(gene name)|psi-mi:VANGL1(display_short)|uniprotkb:STB2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001165882.1|refseq:NP_001165883.1|refseq:NP_620409.1|ensembl:ENSG00000173218(gene)|ensembl:ENST00000310260(transcript)|ensembl:ENST00000355485(transcript)|ensembl:ENST00000369509(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0043473"(pigmentation)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR009539(Strabismus)|mint:Q8TAA9|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9035034|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:TRLqwMf+W5eZcgW8gT5S1zM9VzU9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q9BRX8 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-4399402|uniprotkb:B2RD81|uniprotkb:Q6UW08|uniprotkb:Q8N2K3|uniprotkb:Q8NBK9|uniprotkb:Q96JR0|ensembl:ENSP00000361254|ensembl:ENSP00000361261|ensembl:ENSP00000361262|ensembl:ENSP00000478152|ensembl:ENSP00000482445 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:pxl2a_human(display_long)|uniprotkb:C10orf58(gene name synonym)|uniprotkb:PAMM(gene name synonym)|uniprotkb:Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes(gene name synonym)|uniprotkb:PRXL2A(gene name)|psi-mi:PRXL2A(display_short)|uniprotkb:FAM213A(gene name synonym)|uniprotkb:Redox-regulatory protein FAM213A(gene name synonym)|uniprotkb:PRO2290(orf name)|uniprotkb:PSEC0139(orf name)|uniprotkb:UNQ611/PRO1198(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_115709.3|refseq:NP_001230707.1|refseq:NP_001230708.1|refseq:NP_001230709.1|refseq:NP_001230710.1|refseq:XP_011538567.1|refseq:XP_011538568.1|refseq:NP_001230711.1|ensembl:ENSG00000122378(gene)|ensembl:ENST00000372181(transcript)|ensembl:ENST00000372187(transcript)|ensembl:ENST00000372188(transcript)|ensembl:ENST00000606162(transcript)|ensembl:ENST00000615554(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0016209"(antioxidant activity)|go:"GO:0045670"(regulation of osteoclast differentiation)|interpro:IPR032801|interpro:IPR032802|mint:Q9BRX8 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:qAvv/5+5HfPHe6kqNCdbmDQvvMw9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q8N4L2 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-2820617|uniprotkb:B2R9H4|uniprotkb:Q68CU2|intact:EBI-28987610|ensembl:ENSP00000285419 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:pp4p2_human(display_long)|uniprotkb:PIP4P2(gene name)|psi-mi:PIP4P2(display_short)|uniprotkb:PtdIns-4,5-P2 4-Ptase II(gene name synonym)|uniprotkb:TMEM55A(gene name synonym)|uniprotkb:Transmembrane protein 55A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_061180.1|ensembl:ENSP00000285419|ensembl:ENSG00000155099(gene)|ensembl:ENST00000285419(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR019178 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:w2OC8ZXfJRHs5PFzU26DLFAWudM9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:Q5VT98 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-14062561|ensembl:ENSP00000473584 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:pra20_human(display_long)|uniprotkb:PRAMEF20(gene name)|psi-mi:PRAMEF20(display_short)|uniprotkb:PRAMEF21(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001093322.2|ensembl:ENSG00000204478(gene)|ensembl:ENST00000602960(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR026271|interpro:IPR032675 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:/VQz+KHgxtYAXXiwYUzjEwNI3Qg9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P19404 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-713665|uniprotkb:Q9BV41|ensembl:ENSP00000327268 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:nduv2_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 24 kDa subunit(gene name synonym)|uniprotkb:NDUFV2(gene name)|psi-mi:NDUFV2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000178127(gene)|ensembl:ENST00000318388(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005829"(cytosol)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|interpro:IPR002023("NADH dehydrogenase (ubiquinone), 24 kDa subunit")|interpro:IPR036249|interpro:IPR041921|interpro:IPR042128|mint:P19404|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|refseq:NP_066552.2 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:5cG/vsBAIJGKAkWlM0S/rmqJqGM9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P17152 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-723946|ensembl:ENSP00000319992|intact:EBI-749474|uniprotkb:Q53YB2 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:tmm11_human(display_long)|uniprotkb:TMEM11(gene name)|psi-mi:TMEM11(display_short)|uniprotkb:C17orf35(gene name synonym)|uniprotkb:PM1(gene name synonym)|uniprotkb:Protein PM1(gene name synonym)|uniprotkb:Protein PMI(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_003867.1|ensembl:ENSG00000178307(gene)|ensembl:ENST00000317635(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR026120|mint:P17152|reactome:R-HSA-8949613 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:tQM/J4n5m5/8PH2niEtjBQY2xoY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:P10176 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-3904738|uniprotkb:P15955|ensembl:ENSP00000321260 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:cox8a_human(display_long)|uniprotkb:COX8A(gene name)|psi-mi:COX8A(display_short)|uniprotkb:COX8(gene name synonym)|uniprotkb:COX8L(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide VIII-liver/heart(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit 8-2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004065.1|ensembl:ENSG00000176340(gene)|ensembl:ENST00000314133(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003205(Cytochrome c oxidase, subunit VIII)|interpro:IPR036548|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:MoHZWOFwMGQo80x6kXBUMM5bhxY9606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O36551 uniprotkb:O43427 intact:EBI-7922178|uniprotkb:Q2HR81|intact:MINT-2824596 intact:EBI-724809|uniprotkb:Q6IBQ3|uniprotkb:Q9HD65|uniprotkb:Q27Q85|uniprotkb:A8K0J7|ensembl:ENSP00000344572 psi-mi:o36551_hhv8(display_long)|uniprotkb:K8.1(gene name)|psi-mi:K8.1(display_short)|uniprotkb:HHV8GK18_gp55(orf name) psi-mi:fibp_human(display_long)|uniprotkb:FGF-1 intracellular-binding protein(gene name synonym)|uniprotkb:FIBP(gene name)|psi-mi:FIBP(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062552|imex:IM-26114-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129404.1|go:"GO:0016021"(integral component of membrane) refseq:NP_004205.2|refseq:NP_942600.1|ensembl:ENSG00000172500(gene)|ensembl:ENST00000338369(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0070527"(platelet aggregation)|interpro:IPR008614(Acidic fibroblast growth factor binding) - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:LDD1/tjXA2B0fFyVRFxeYHdqlYw37296 rogid:ejFo8TLe0Ep7XxbwAY7EijdiY609606 rigid:mfKFTahrfnHu7/5vGjvjUGqxZE8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:P20719 intact:EBI-14062647 intact:EBI-8470697|uniprotkb:Q96CY6|intact:MINT-2801671|uniprotkb:O43367|uniprotkb:A4D179|ensembl:ENSP00000222726 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:hxa5_human(display_long)|uniprotkb:HOXA5(gene name)|psi-mi:HOXA5(display_short)|uniprotkb:HOX1C(gene name synonym)|uniprotkb:Homeobox protein Hox-1C(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_061975.2|ensembl:ENSG00000106004(gene)|ensembl:ENST00000222726(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003016"(respiratory system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030878"(thyroid gland development)|go:"GO:0033599"(regulation of mammary gland epithelial cell proliferation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060435"(bronchiole development)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060480"(lung goblet cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0060638"(mesenchymal-epithelial cell signaling)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060764"(cell-cell signaling involved in mammary gland development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR001827(Homeobox protein, antennapedia type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR017995|interpro:IPR020479|mint:P20719 - - comment:mint|comment:homomint|function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:1W+oOoovKja439tdjkg3QjmSB9Q9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q6ZN17 intact:EBI-14062647 intact:EBI-2462592|uniprotkb:B2RPN6|uniprotkb:A1L165|uniprotkb:Q5TCM4|ensembl:ENSP00000344401 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:ln28b_human(display_long)|uniprotkb:LIN28B(gene name)|psi-mi:LIN28B(display_short)|uniprotkb:CSDD2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001004317.1|ensembl:ENSG00000187772(gene)|ensembl:ENST00000345080(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0050779"(RNA destabilization)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|go:"GO:2000632"(negative regulation of pre-miRNA processing)|go:"GO:2000635"(negative regulation of primary miRNA processing)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR036875|rcsb pdb:4A4I - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:fsajK9bTHAkQUEfwVbobY9jrS9M9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q1ED39 intact:EBI-14062647 intact:EBI-9977982|uniprotkb:O43328|uniprotkb:Q5FWF3|ensembl:ENSP00000219837 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:knop1_human(display_long)|uniprotkb:KNOP1(gene name)|psi-mi:KNOP1(display_short)|uniprotkb:C16orf88(gene name synonym)|uniprotkb:FAM191A(gene name synonym)|uniprotkb:TSG118(gene name synonym)|uniprotkb:Protein FAM191A(gene name synonym)|uniprotkb:Testis-specific gene 118 protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001013009.2|refseq:NP_001335457.1|refseq:NP_001335458.1|refseq:NP_001335459.1|refseq:NP_001335460.1|ensembl:ENSG00000103550(gene)|ensembl:ENST00000219837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|interpro:IPR028124 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:DbTowYDo0km0cUlAS8TTL5JIyyQ9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9NUL7 intact:EBI-14062647 intact:EBI-2560229|ensembl:ENSP00000332340 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:ddx28_human(display_long)|uniprotkb:DDX28(gene name)|psi-mi:DDX28(display_short)|uniprotkb:MDDX28(gene name synonym)|uniprotkb:Mitochondrial DEAD box protein 28(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_060850.2|ensembl:ENSG00000182810(gene)|ensembl:ENST00000332395(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019843"(rRNA binding)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902775"(mitochondrial large ribosomal subunit assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:aq2jUV+jvcoBIROUedWr86FxEl89606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9P031 intact:EBI-14062647 intact:EBI-1047110|uniprotkb:Q9H2V5|uniprotkb:Q9NW62|ensembl:ENSP00000256151 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:tap26_human(display_long)|uniprotkb:TTF-1-associated protein BR2(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 59(gene name synonym)|uniprotkb:CCDC59(gene name)|psi-mi:CCDC59(display_short)|uniprotkb:BR22(gene name synonym)|uniprotkb:TAP26(gene name synonym)|uniprotkb:HSPC128(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_054886.2|ensembl:ENSG00000133773(gene)|ensembl:ENST00000256151(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR013730(rRNA processing)|reactome:R-HSA-5683826 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:p0UHejV9vxOkT8NrUysz7hmdOW49606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q14493 intact:EBI-14062647 intact:EBI-2696402|uniprotkb:B3KRJ5|ensembl:ENSP00000417686 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001293003.1|refseq:NP_001293004.1|refseq:NP_006518.1|ensembl:ENSG00000163950(gene)|ensembl:ENST00000489418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR026502|interpro:IPR029344|interpro:IPR038294|mint:Q14493|rcsb pdb:2KJM|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-159230|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-57045N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q8N567 intact:EBI-14062647 intact:EBI-5235536|uniprotkb:B2RAE7|uniprotkb:Q9H027|ensembl:ENSP00000254037|ensembl:ENSP00000369546|ensembl:ENSP00000385047|ensembl:ENSP00000412637 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:zchc9_human(display_long)|uniprotkb:ZCCHC9(gene name)|psi-mi:ZCCHC9(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001124507.1|refseq:NP_001124508.1|refseq:NP_115656.1|ensembl:ENSG00000131732(gene)|ensembl:ENST00000254037(transcript)|ensembl:ENST00000380199(transcript)|ensembl:ENST00000407610(transcript)|ensembl:ENST00000438268(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|interpro:IPR042246 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:M/NIA60lFfPQAjGBMtHILP1zw/s9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:O15211 intact:EBI-14062647 intact:EBI-712355|ensembl:ENSP00000372691|ensembl:ENSP00000390098|ensembl:ENSP00000407088|ensembl:ENSP00000412152|ensembl:ENSP00000420211|uniprotkb:Q9Y3F3|uniprotkb:Q5STK0|uniprotkb:B4DG72 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:rgl2_human(display_long)|uniprotkb:RAB2L(gene name synonym)|uniprotkb:RalGDS-like factor(gene name synonym)|uniprotkb:RGL2(gene name)|psi-mi:RGL2(display_short)|uniprotkb:Ras-associated protein RAB2L(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001230667.1|refseq:NP_004752.1|ensembl:ENSG00000206282(gene)|ensembl:ENSG00000224841(gene)|ensembl:ENSG00000228736(gene)|ensembl:ENSG00000237441(gene)|ensembl:ENSG00000237825(gene)|ensembl:ENST00000383204(transcript)|ensembl:ENST00000413136(transcript)|ensembl:ENST00000416548(transcript)|ensembl:ENST00000452084(transcript)|ensembl:ENST00000497454(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0032485"(regulation of Ral protein signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR030749|interpro:IPR036964|reactome:R-HSA-5673001|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:SAyeE2O2Y/3UBRtupBnEUORpglg9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q96GY0 intact:EBI-14062647 intact:EBI-5458880|uniprotkb:Q9Y372|ensembl:ENSP00000263849 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:zc21a_human(display_long)|uniprotkb:ZC2HC1A(gene name)|psi-mi:ZC2HC1A(display_short)|uniprotkb:C8orf70(gene name synonym)|uniprotkb:FAM164A(gene name synonym)|uniprotkb:CGI-62(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_057094.2|ensembl:ENSG00000104427(gene)|ensembl:ENST00000263849(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR026319 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:5QYEwHhPJBrdqbU1jKnxdZFYC7c9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q6ZSJ8 intact:EBI-14062647 intact:EBI-3942447|uniprotkb:Q56A71|uniprotkb:A2RQF4|uniprotkb:E9PQ13|ensembl:ENSP00000362133 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:ca122_human(display_long)|uniprotkb:C1orf122(gene name)|psi-mi:C1orf122(display_short)|uniprotkb:Protein ALAESM(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001136198.1|refseq:NP_940848.2|ensembl:ENSG00000197982(gene)|ensembl:ENST00000373042(transcript)|interpro:IPR031714 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:WMt8x9aS0RWRiSE7ckfKGm4KzPA9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q8TBK6 intact:EBI-14062647 intact:EBI-597063|uniprotkb:Q9NXR4|ensembl:ENSP00000423276 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:zch10_human(display_long)|uniprotkb:ZCCHC10(gene name)|psi-mi:ZCCHC10(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_060135.1|refseq:NP_001287746.1|refseq:NP_001287747.1|refseq:NP_001287748.1|refseq:NP_001287751.1|refseq:NP_001295056.1|refseq:NP_001295057.1|refseq:NP_001295058.1|refseq:NP_001295059.1|refseq:NP_001287745.1|ensembl:ENSG00000155329(gene)|ensembl:ENST00000509437(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR036875|interpro:IPR039715 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:WcCfa6tnoaA9NGta4vXKUY3VnxI9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9P2N5 intact:EBI-14062647 intact:EBI-2801823|uniprotkb:Q8IYW9|ensembl:ENSP00000265271 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:rbm27_human(display_long)|uniprotkb:KIAA1311(gene name synonym)|uniprotkb:RNA-binding motif protein 27(gene name synonym)|uniprotkb:RBM27(gene name)|psi-mi:RBM27(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_061862.1|ensembl:ENSG00000091009(gene)|ensembl:ENST00000265271(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034451|interpro:IPR035979 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:TOeh1JAElLGeLfz+YkgWIsS4V0k9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9BQ04 intact:EBI-14062647 intact:EBI-715531|uniprotkb:B3KT83|ensembl:ENSP00000310471|ensembl:ENSP00000433071 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:rbm4b_human(display_long)|uniprotkb:RNA-binding motif protein 4B(gene name synonym)|uniprotkb:RNA-binding protein 30(gene name synonym)|uniprotkb:RNA-binding motif protein 30(gene name synonym)|uniprotkb:RBM4B(gene name)|psi-mi:RBM4B(display_short)|uniprotkb:RBM30(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001273064.1|refseq:NP_113680.1|refseq:XP_011543599.1|ensembl:ENSG00000173914(gene)|ensembl:ENST00000310046(transcript)|ensembl:ENST00000525754(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034897|interpro:IPR034898|interpro:IPR035979|mint:Q9BQ04|rcsb pdb:2DGT|refseq:XP_016873891.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:3EzHpurWDZlPeaLV0EFAAAo2MO09606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9UL40 intact:EBI-14062647 intact:EBI-2462313|uniprotkb:B7Z367|uniprotkb:Q68CV9|uniprotkb:Q6ZMW1|ensembl:ENSP00000350869 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:zn346_human(display_long)|uniprotkb:ZNF346(gene name)|psi-mi:ZNF346(display_short)|uniprotkb:JAZ(gene name synonym)|uniprotkb:Just another zinc finger protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001295142.1|refseq:NP_001295143.1|refseq:NP_001295148.1|refseq:NP_001295152.1|refseq:NP_036411.1|refseq:XP_016864784.1|refseq:XP_016864785.1|ensembl:ENSG00000113761(gene)|ensembl:ENST00000358149(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0035198"(miRNA binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2MKD|rcsb pdb:2MKN - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:bK/y4NYSSsa1tcNjtbmsEmkSp7Q9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:P16278 intact:EBI-14062647 intact:EBI-989638|uniprotkb:B7Z6B0|intact:EBI-1018741|uniprotkb:P16279|ensembl:ENSP00000306920|ensembl:ENSP00000382333|uniprotkb:B2R7H8 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:bgal_human(display_long)|uniprotkb:ELNR1(gene name synonym)|uniprotkb:Acid beta-galactosidase(gene name synonym)|uniprotkb:Elastin receptor 1(gene name synonym)|uniprotkb:GLB1(gene name)|psi-mi:GLB1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_000395.2|refseq:NP_001073279.1|refseq:NP_001129074.1|ensembl:ENSG00000170266(gene)|ensembl:ENST00000399402(transcript)|go:"GO:0004565"(beta-galactosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0016936"(galactoside binding)|go:"GO:0019388"(galactose catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042340"(keratan sulfate catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044262"(cellular carbohydrate metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051413"(response to cortisone)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001944(Glycoside hydrolase, family 35)|interpro:IPR008979(Galactose-binding like)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR019801|interpro:IPR025300|interpro:IPR026283|interpro:IPR031330|mint:P16278|rcsb pdb:3THC|rcsb pdb:3THD|rcsb pdb:3WEZ|rcsb pdb:3WF0|rcsb pdb:3WF1|rcsb pdb:3WF2|rcsb pdb:3WF3|rcsb pdb:3WF4|reactome:R-HSA-1660662|reactome:R-HSA-2022857|reactome:R-HSA-2024096|reactome:R-HSA-2206308|reactome:R-HSA-4085001|ensembl:ENST00000307363(transcript)|reactome:R-HSA-4341670|reactome:R-HSA-6798695|refseq:NP_001303969.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:L/REQ2uBBZimHZnDpo3URvdGTdA9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9ULM3 intact:EBI-14062647 intact:EBI-2795509|uniprotkb:A7E2B9|uniprotkb:Q641P6|uniprotkb:Q9NW96|uniprotkb:D3DNS9|ensembl:ENSP00000306983 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:yets2_human(display_long)|uniprotkb:YEATS2(gene name)|psi-mi:YEATS2(display_short)|uniprotkb:KIAA1197(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_060493.3|refseq:XP_016862298.1|refseq:XP_016862299.1|reactome:R-HSA-3214847|rcsb pdb:6LSD|ensembl:ENST00000305135(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0072686"(mitotic spindle)|go:"GO:0140030"(modification-dependent protein binding)|interpro:IPR005033(YEATS)|interpro:IPR038704|mint:Q9ULM3|rcsb pdb:5IQL|ensembl:ENSG00000163872(gene)|rcsb pdb:5XNV - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:dbdCDssB6o5aHKaRdnvITi8b/v09606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q8N5P1 intact:EBI-14062647 intact:EBI-5280267|uniprotkb:Q9BZ75|ensembl:ENSP00000272570|ensembl:ENSP00000386488 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:zc3h8_human(display_long)|uniprotkb:ZC3H8(gene name)|psi-mi:ZC3H8(display_short)|uniprotkb:ZC3HDC8(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_115883.2|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|mint:Q8N5P1|reactome:R-HSA-6807505|ensembl:ENSG00000144161(gene)|ensembl:ENST00000272570(transcript)|ensembl:ENST00000409573(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0035327" - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:ltW8I583M/LV8XKPzLRvojXc+AA9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92597 uniprotkb:Q9BRP8 intact:EBI-14062647 intact:EBI-2352802|uniprotkb:Q8IXJ8|uniprotkb:Q8N8E7|uniprotkb:B6ZDM5|ensembl:ENSP00000386156 psi-mi:o92597_hhv8(display_long)|uniprotkb:k8(gene name)|psi-mi:k8(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:K8(gene name synonym) psi-mi:pym1_human(display_long)|uniprotkb:PYM1(gene name)|psi-mi:PYM1(display_short)|uniprotkb:PYM(gene name synonym)|uniprotkb:PYM homolog 1 exon junction complex-associated factor(gene name synonym)|uniprotkb:Protein wibg homolog(gene name synonym)|uniprotkb:WIBG(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062645|imex:IM-26114-107 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001137325.1|refseq:NP_115721.1|dip:DIP-48413N|ensembl:ENSG00000170473(gene)|ensembl:ENST00000408946(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1903259"(exon-exon junction complex disassembly)|interpro:IPR015362(Exon junction complex, Pym)|interpro:IPR036348|interpro:IPR039333|mint:Q9BRP8 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:VzLZzYqkCnsYlIjlKVUBNSUwNIM37296 rogid:REnCXPEpBBYprj7V0RQLJecl+Ug9606 rigid:ZOnEl2HU8PlK8Ikuf2iMBdqENek false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:P28370 intact:EBI-14062676 intact:EBI-2822460|uniprotkb:Q5JV41|uniprotkb:Q5JV42|ensembl:ENSP00000360163 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:smca1_human(display_long)|uniprotkb:SMARCA1(gene name)|psi-mi:SMARCA1(display_short)|uniprotkb:SNF2L(gene name synonym)|uniprotkb:SNF2L1(gene name synonym)|uniprotkb:ATP-dependent helicase SMARCA1(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit SNF2L(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_003060.2|refseq:NP_001269804.1|refseq:XP_006724845.1|refseq:XP_016885239.1|refseq:XP_005262518.1|dip:DIP-57685N|ensembl:ENSG00000102038(gene)|ensembl:ENST00000371122(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007420"(brain development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016589"(NURF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0090537"(CERF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR009057(Homeodomain-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015194(Nucleosome remodelling ATPase ISWI, HAND)|interpro:IPR015195(SLIDE)|interpro:IPR017884|interpro:IPR020838|interpro:IPR027417|interpro:IPR036306|interpro:IPR038718|interpro:IPR044755|mint:P28370 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:BBDJMLUdqadz6iXLKjLJto+XF5s9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q12899 intact:EBI-14062676 intact:EBI-2341136|intact:EBI-2802887|uniprotkb:A6NG96|uniprotkb:Q5SRL2|ensembl:ENSP00000331131|ensembl:ENSP00000373102|ensembl:ENSP00000379806|ensembl:ENSP00000389203|ensembl:ENSP00000390258|ensembl:ENSP00000391879|ensembl:ENSP00000392805|ensembl:ENSP00000393011|ensembl:ENSP00000394371|ensembl:ENSP00000394421|ensembl:ENSP00000395491|ensembl:ENSP00000396188|ensembl:ENSP00000398545|ensembl:ENSP00000402395|ensembl:ENSP00000406707|ensembl:ENSP00000407294|ensembl:ENSP00000407876|ensembl:ENSP00000408233|ensembl:ENSP00000409182|ensembl:ENSP00000410446|ensembl:ENSP00000414248|ensembl:ENSP00000415328|ensembl:ENSP00000415755|ensembl:ENSP00000416737 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:tri26_human(display_long)|uniprotkb:TRIM26(gene name)|psi-mi:TRIM26(display_short)|uniprotkb:RNF95(gene name synonym)|uniprotkb:ZNF173(gene name synonym)|uniprotkb:Zinc finger protein 173(gene name synonym)|uniprotkb:Acid finger protein(gene name synonym)|uniprotkb:RING finger protein 95(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:XP_006715243.1|refseq:NP_001229712.1|refseq:NP_003440.1|refseq:XP_005249431.1|refseq:XP_005249432.1|refseq:XP_005249433.1|refseq:XP_005249434.1|refseq:XP_005249435.1|dip:DIP-52853N|ensembl:ENSG00000137313(gene)|ensembl:ENSG00000226060(gene)|ensembl:ENSG00000228881(gene)|ensembl:ENSG00000230230(gene)|ensembl:ENSG00000231002(gene)|ensembl:ENSG00000231641(gene)|ensembl:ENSG00000234046(gene)|ensembl:ENSG00000234127(gene)|ensembl:ENST00000327357(transcript)|ensembl:ENST00000383607(transcript)|ensembl:ENST00000396558(transcript)|ensembl:ENST00000415923(transcript)|ensembl:ENST00000422349(transcript)|ensembl:ENST00000425523(transcript)|ensembl:ENST00000425831(transcript)|ensembl:ENST00000427535(transcript)|ensembl:ENST00000428486(transcript)|ensembl:ENST00000432326(transcript)|ensembl:ENST00000433314(transcript)|ensembl:ENST00000436219(transcript)|ensembl:ENST00000437089(transcript)|ensembl:ENST00000438384(transcript)|ensembl:ENST00000438908(transcript)|ensembl:ENST00000439094(transcript)|ensembl:ENST00000445259(transcript)|ensembl:ENST00000447711(transcript)|ensembl:ENST00000450392(transcript)|ensembl:ENST00000453195(transcript)|ensembl:ENST00000454678(transcript)|ensembl:ENST00000455000(transcript)|ensembl:ENST00000456093(transcript)|ensembl:ENST00000456770(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR043136|mint:Q12899|reactome:R-HSA-877300 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:GPu3YgJ3xR1pN/MM9IKU3unCj1A9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q9BY44 intact:EBI-14062676 intact:EBI-1776615|uniprotkb:Q5QTR2|uniprotkb:Q7Z4E9|uniprotkb:Q8NFM1|uniprotkb:Q96EW9|uniprotkb:Q96K81|uniprotkb:A8MPS6|uniprotkb:B4DF96|uniprotkb:B4DQ14|uniprotkb:D3DNI9|ensembl:ENSP00000417229 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:eif2a_human(display_long)|uniprotkb:EIF2A(gene name)|psi-mi:EIF2A(display_short)|uniprotkb:CDA02(orf name)|uniprotkb:MSTP004(orf name)|uniprotkb:MSTP089(orf name)|uniprotkb:65 kDa eukaryotic translation initiation factor 2A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_114414.2|refseq:NP_001305972.1|refseq:NP_001305973.1|refseq:NP_001305974.1|refseq:NP_001305975.1|dip:DIP-40272N|ensembl:ENSG00000144895(gene)|ensembl:ENST00000460851(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0042255"(ribosome assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1990928"(response to amino acid starvation)|interpro:IPR011387(Translation initiation factor eIF-2A)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9BY44 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:67hYEz0CrhoQ7SfXxZdOWqKzil89606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q66PJ3 intact:EBI-14062676 intact:EBI-2683099|uniprotkb:Q9NR05|uniprotkb:Q4F966|uniprotkb:Q9P2R9|uniprotkb:Q96BI2|uniprotkb:Q504R8|uniprotkb:A4UCR8|uniprotkb:B3V0L0|uniprotkb:B3V0L1 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:ar6p4_human(display_long)|uniprotkb:HSP-975(gene name synonym)|uniprotkb:HSVI-binding protein(gene name synonym)|uniprotkb:SR-15(gene name synonym)|uniprotkb:SRp25(gene name synonym)|uniprotkb:Splicing factor SRrp37(gene name synonym)|uniprotkb:ARL6IP4(gene name)|psi-mi:ARL6IP4(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) interpro:IPR019532|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|refseq:NP_001002251.2|refseq:NP_001002252.2|refseq:NP_001265307.1|refseq:NP_001265308.1|refseq:NP_001265309.1|refseq:NP_061164.3|refseq:NP_057722.3|mint:Q66PJ3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:ZNWWhsvMwbPRZb3BlP50N3hc4Ls9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q5VWQ0 intact:EBI-14062676 intact:EBI-1210591|uniprotkb:Q6AI21|uniprotkb:Q8TC33|uniprotkb:Q9HA80|uniprotkb:Q9NUP6|uniprotkb:A8K937|intact:EBI-28967842|ensembl:ENSP00000261441|ensembl:ENSP00000479490 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:rsbn1_human(display_long)|uniprotkb:RSBN1(gene name)|psi-mi:RSBN1(display_short)|uniprotkb:Round spermatid basic protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_060834.2|ensembl:ENSP00000261441|ensembl:ENSP00000479490|refseq:XP_016857007.1|ensembl:ENSG00000081019(gene)|ensembl:ENST00000612242(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|interpro:IPR026306|ensembl:ENST00000261441(transcript) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:Mf1J8EtFQGLQvNao9oFZv3oy0ek9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q9NP64 intact:EBI-14062676 intact:EBI-746345|uniprotkb:Q6PKH4|uniprotkb:Q9NYG4|uniprotkb:Q9P0M8|uniprotkb:D3DPN4|ensembl:ENSP00000343557|ensembl:ENSP00000362819|uniprotkb:B4DY38 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:no40_human(display_long)|uniprotkb:Zinc finger CCHC domain-containing protein 17(gene name synonym)|uniprotkb:Putative S1 RNA-binding domain protein(gene name synonym)|uniprotkb:Pnn-interacting nucleolar protein(gene name synonym)|uniprotkb:ZCCHC17(gene name)|psi-mi:ZCCHC17(display_short)|uniprotkb:HSPC243(orf name)|uniprotkb:HSPC251(orf name)|uniprotkb:LDC4(orf name)|uniprotkb:PS1D(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001269495.1|refseq:NP_001269496.1|refseq:NP_001269497.1|refseq:NP_001269498.1|refseq:NP_001269499.1|refseq:NP_001269500.1|refseq:NP_001269501.1|refseq:NP_001269502.1|refseq:NP_001269503.1|refseq:XP_006710744.1|refseq:NP_057589.2|refseq:XP_011539869.1|ensembl:ENSG00000121766(gene)|ensembl:ENST00000344147(transcript)|ensembl:ENST00000373714(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR003029(S1, RNA binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR037320|mint:Q9NP64|rcsb pdb:2CQO - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:e71wAulRWX6cM59s3g8R42PWXeU9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q9HCM4 intact:EBI-14062676 intact:EBI-1047162|uniprotkb:Q8IZ12|uniprotkb:Q9H975|uniprotkb:Q7Z5S1|ensembl:ENSP00000263713 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:e41l5_human(display_long)|uniprotkb:KIAA1548(gene name synonym)|uniprotkb:EPB41L5(gene name)|psi-mi:EPB41L5(display_short)|uniprotkb:Erythrocyte membrane protein band 4.1-like 5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001171866.1|refseq:NP_001171867.1|refseq:NP_001171868.1|refseq:NP_065960.2|refseq:NP_001317239.1|ensembl:ENSG00000115109(gene)|ensembl:ENST00000263713(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001839"(neural plate morphogenesis)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003383"(apical constriction)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006931"(substrate-dependent cell migration, cell attachment to substrate)|go:"GO:0007398"(ectoderm development)|go:"GO:0007492"(endoderm development)|go:"GO:0007509"(mesoderm migration involved in gastrulation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009826"(unidimensional cell growth)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032587"(ruffle membrane)|go:"GO:0048319"(axial mesoderm morphogenesis)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030694|interpro:IPR035963|reactome:R-HSA-6794361 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:CJuB1zHpmsK3te4K5lBNrL5tyxc9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:A4D1E9 intact:EBI-14062676 intact:EBI-5453796|uniprotkb:B4DFY6|uniprotkb:Q3B7A6|uniprotkb:Q5H9V2|uniprotkb:Q8IXG8|uniprotkb:Q8N982|uniprotkb:Q8WU16|uniprotkb:Q9BSP1|uniprotkb:Q9Y6T6|ensembl:ENSP00000222511 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:gtpba_human(display_long)|uniprotkb:GTPBP10(gene name)|psi-mi:GTPBP10(display_short)|uniprotkb:OBGH2(gene name synonym)|uniprotkb:Protein obg homolog 2(gene name synonym)|uniprotkb:UG0751c10(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001036182.1|refseq:NP_149098.2|ensembl:ENSG00000105793(gene)|ensembl:ENST00000222511(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR006169(GTP1/OBG subdomain)|interpro:IPR027417|interpro:IPR031167|interpro:IPR035101|interpro:IPR036726 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:rxJN6IWcF54XIXy3AvOt9JN9m/U9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q8IVS2 intact:EBI-14062676 intact:EBI-1210664|uniprotkb:B0QY72|uniprotkb:O95510|uniprotkb:O95511|ensembl:ENSP00000290429 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:fabd_human(display_long)|uniprotkb:MCAT(gene name)|psi-mi:MCAT(display_short)|uniprotkb:MT(gene name synonym)|uniprotkb:Mitochondrial malonyltransferase(gene name synonym)|uniprotkb:[Acyl-carrier-protein] malonyltransferase(gene name synonym)|uniprotkb:"Mitochondrial malonyl CoA:ACP acyltransferase"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_055322.1|refseq:NP_775738.3|ensembl:ENSG00000100294(gene)|ensembl:ENST00000290429(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004312"(fatty acid synthase activity)|go:"GO:0004314"([acyl-carrier-protein] S-malonyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|interpro:IPR001227(Acyl transferase region)|interpro:IPR014043(Acyl transferase)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR016036(Malonyl-CoA ACP transacylase, ACP-binding)|rcsb pdb:2C2N|reactome:R-HSA-77289 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:6Uw/NgJstPl1ycA9jOFqnocYyPM9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:Q9NUQ6 intact:EBI-14062676 intact:EBI-5280638|uniprotkb:A8K381|uniprotkb:B7WNZ7|uniprotkb:Q53T22|uniprotkb:Q8WV53|uniprotkb:Q8WYG1|uniprotkb:Q9NTW4|uniprotkb:B4DRE6|uniprotkb:B4DT67|ensembl:ENSP00000351503|ensembl:ENSP00000386336|ensembl:ENSP00000386730|ensembl:ENSP00000386931|ensembl:ENSP00000391467 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:sps2l_human(display_long)|uniprotkb:SPATS2L(gene name)|psi-mi:SPATS2L(display_short)|uniprotkb:DNAPTP6(gene name synonym)|uniprotkb:DNA polymerase-transactivated protein 6(gene name synonym)|uniprotkb:Stress granule and nucleolar protein(gene name synonym)|uniprotkb:SP1224(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_001269664.1|refseq:NP_001269672.1|refseq:XP_011509240.1|refseq:XP_011509241.1|refseq:NP_001093892.1|refseq:NP_001093893.1|refseq:NP_001093894.1|refseq:NP_056350.2|refseq:XP_005246513.1|refseq:XP_005246514.1|refseq:XP_005246515.1|refseq:XP_005246516.1|refseq:NP_001269673.1|refseq:XP_016859272.1|refseq:XP_016859274.1|refseq:XP_016859275.1|refseq:XP_016859276.1|ensembl:ENSG00000196141(gene)|ensembl:ENST00000358677(transcript)|ensembl:ENST00000409140(transcript)|ensembl:ENST00000409718(transcript)|ensembl:ENST00000409988(transcript)|ensembl:ENST00000451764(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|mint:Q9NUQ6 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:B+nzSpiu2ECSVNxsajBSZrk6dhA9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:P16278 intact:EBI-14062676 intact:EBI-989638|uniprotkb:B7Z6B0|intact:EBI-1018741|uniprotkb:P16279|ensembl:ENSP00000306920|ensembl:ENSP00000382333|uniprotkb:B2R7H8 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:bgal_human(display_long)|uniprotkb:ELNR1(gene name synonym)|uniprotkb:Acid beta-galactosidase(gene name synonym)|uniprotkb:Elastin receptor 1(gene name synonym)|uniprotkb:GLB1(gene name)|psi-mi:GLB1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) refseq:NP_000395.2|refseq:NP_001073279.1|refseq:NP_001129074.1|ensembl:ENSG00000170266(gene)|ensembl:ENST00000399402(transcript)|go:"GO:0004565"(beta-galactosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0016936"(galactoside binding)|go:"GO:0019388"(galactose catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042340"(keratan sulfate catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044262"(cellular carbohydrate metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051413"(response to cortisone)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001944(Glycoside hydrolase, family 35)|interpro:IPR008979(Galactose-binding like)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR019801|interpro:IPR025300|interpro:IPR026283|interpro:IPR031330|mint:P16278|rcsb pdb:3THC|rcsb pdb:3THD|rcsb pdb:3WEZ|rcsb pdb:3WF0|rcsb pdb:3WF1|rcsb pdb:3WF2|rcsb pdb:3WF3|rcsb pdb:3WF4|reactome:R-HSA-1660662|reactome:R-HSA-2022857|reactome:R-HSA-2024096|reactome:R-HSA-2206308|reactome:R-HSA-4085001|ensembl:ENST00000307363(transcript)|reactome:R-HSA-4341670|reactome:R-HSA-6798695|refseq:NP_001303969.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:L/REQ2uBBZimHZnDpo3URvdGTdA9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9WRJ7 uniprotkb:P10619 intact:EBI-14062676 intact:EBI-989654|uniprotkb:Q9BW68|uniprotkb:Q561W6|uniprotkb:Q5JZH1|uniprotkb:Q96KJ2|uniprotkb:Q9BR08|ensembl:ENSP00000361537|ensembl:ENSP00000475524|ensembl:ENSP00000493613|ensembl:ENSP00000191018|uniprotkb:B2R798 psi-mi:q9wrj7_hhv8(display_long)|uniprotkb:KIE-1(gene name)|psi-mi:KIE-1(display_short)|uniprotkb:K8(gene name synonym) psi-mi:ppgb_human(display_long)|uniprotkb:Cathepsin A(gene name synonym)|uniprotkb:Carboxypeptidase C(gene name synonym)|uniprotkb:Protective protein for beta-galactosidase(gene name synonym)|uniprotkb:CTSA(gene name)|psi-mi:CTSA(display_short)|uniprotkb:PPGB(gene name synonym)|uniprotkb:Carboxypeptidase L(gene name synonym)|uniprotkb:Protective protein cathepsin A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062674|imex:IM-26114-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR010805(Kaposi s sarcoma-associated herpesvirus K8) ensembl:ENSG00000064601(gene)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR029058|interpro:IPR033124|rcsb pdb:1IVY|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BXN|rcsb pdb:4AZ0|rcsb pdb:4AZ3|rcsb pdb:4CI9|rcsb pdb:4CIA|rcsb pdb:4CIB|rcsb pdb:4MWS|rcsb pdb:4MWT|rcsb pdb:6WIA|reactome:R-HSA-1660662|reactome:R-HSA-2132295|reactome:R-HSA-4085001|reactome:R-HSA-4341670|reactome:R-HSA-6798695|ensembl:ENST00000191018(transcript)|ensembl:ENST00000372459(transcript)|ensembl:ENST00000607482(transcript)|ensembl:ENST00000646241(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006508"(proteolysis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904715"(negative regulation of chaperone-mediated autophagy)|refseq:NP_000299.2|refseq:NP_001161066.1|refseq:NP_001121167.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:hkUKPHqeEbAYfJbJZXjVoZvMQwg37296 rogid:l/CZaKjZTuZu1ROoJJZVsxobYrQ9606 rigid:so6CLfp8mK5jNWMRwiIrUNNf4ZE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q9NZI7 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-2795133|uniprotkb:Q68CT0|uniprotkb:Q86Y57|uniprotkb:Q9H8V0|uniprotkb:Q9UD76|uniprotkb:Q9UD78|ensembl:ENSP00000283628|ensembl:ENSP00000283629 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:ubip1_human(display_long)|uniprotkb:UBP1(gene name)|psi-mi:UBP1(display_short)|uniprotkb:LBP1(gene name synonym)|uniprotkb:Transcription factor LBP-1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_001121632.1|refseq:NP_001121633.1|refseq:NP_055332.3|ensembl:ENSG00000153560(gene)|ensembl:ENST00000283628(transcript)|ensembl:ENST00000283629(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037600|interpro:IPR041418|mint:Q9NZI7|go:"GO:0032897"(negative regulation of viral transcription) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:aMcHSKF2w0CPIYmoyowV2a3I9Tk9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q12800 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-717422|uniprotkb:Q12801|uniprotkb:Q9UD77|uniprotkb:A8K5E9|uniprotkb:Q9UD75|ensembl:ENSP00000257915 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:tfcp2_human(display_long)|uniprotkb:Transcription factor LSF(gene name synonym)|uniprotkb:SAA3 enhancer factor(gene name synonym)|uniprotkb:TFCP2(gene name)|psi-mi:TFCP2(display_short)|uniprotkb:LSF(gene name synonym)|uniprotkb:SEF(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_001166923.1|refseq:NP_001166924.1|refseq:NP_005644.2|ensembl:ENSG00000135457(gene)|ensembl:ENST00000257915(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR007604(CP2 transcription factor)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037599|interpro:IPR041418|mint:Q12800 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:M7mQ08NDYxuawmUEKRgjSdIr+Og9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:O75487 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-3050469|uniprotkb:B4E2C0|ensembl:ENSP00000359864|uniprotkb:B2R6J7|uniprotkb:Q9UPD9|uniprotkb:Q96L43|uniprotkb:Q9NU08|uniprotkb:Q6ZMA6|uniprotkb:Q9UJN1 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:gpc4_human(display_long)|uniprotkb:GPC4(gene name)|psi-mi:GPC4(display_short)|uniprotkb:K-glypican(gene name synonym)|uniprotkb:UNQ474/PRO937(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 ensembl:ENSG00000076716(gene)|ensembl:ENST00000370828(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|mint:O75487|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045202"(synapse)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1904929"(coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR001863(Glypican)|interpro:IPR019803|interpro:IPR031180|go:"GO:0016055"(Wnt signaling pathway)|refseq:NP_001439.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:6IC3ItqIRoNTmnS+hi/U34DlXN09606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q92901 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-2514377|ensembl:ENSP00000268661 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:rl3l_human(display_long)|uniprotkb:RPL3L(gene name)|psi-mi:RPL3L(display_short)|uniprotkb:Large ribosomal subunit protein uL3-like(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 ensembl:ENSG00000140986(gene)|ensembl:ENST00000268661(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_005052.1|ensembl:ENSP00000268661 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:hG1wpRH7DNIbNB4zCONsF22W3zc9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:P06400 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-491274|uniprotkb:P78499|uniprotkb:Q5VW46|uniprotkb:Q8IZL4|uniprotkb:A8K5E3|ensembl:ENSP00000267163 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:rb_human(display_long)|uniprotkb:pRb(gene name synonym)|uniprotkb:pp110(gene name synonym)|uniprotkb:p105-Rb(gene name synonym)|uniprotkb:RB1(gene name)|psi-mi:RB1(display_short)|uniprotkb:p110-RB1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 go:"GO:1903055"(positive regulation of extracellular matrix organization)|refseq:NP_000312.2|go:"GO:1904028"(positive regulation of collagen fibril organization)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR036915|mint:P06400|rcsb pdb:1AD6|rcsb pdb:1GH6|rcsb pdb:1GUX|rcsb pdb:1H25|rcsb pdb:1N4M|rcsb pdb:1O9K|rcsb pdb:1PJM|rcsb pdb:2AZE|rcsb pdb:2QDJ|rcsb pdb:2R7G|rcsb pdb:3N5U|rcsb pdb:3POM|rcsb pdb:4CRI|rcsb pdb:4ELJ|rcsb pdb:4ELL|reactome:R-HSA-113501|reactome:R-HSA-174178|reactome:R-HSA-2299718|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69656|reactome:R-HSA-8940973|reactome:R-HSA-9661069|reactome:R-HSA-9661070|reactome:R-HSA-9682706|reactome:R-HSA-9687136|reactome:R-HSA-9694686|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016605"(PML body)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0019900"(kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031134"(sister chromatid biorientation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035189"(Rb-E2F complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042551"(neuron maturation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048565"(digestive tract development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071922"(regulation of cohesin loading)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090230"(regulation of centromere complex assembly)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|ensembl:ENSG00000139687(gene)|ensembl:ENST00000267163(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-582N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:xidCNX96KlQzu160polvT61k4Zw9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:P34741 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-1172957|uniprotkb:Q9H6V1|uniprotkb:B3KQA3|ensembl:ENSP00000307046|uniprotkb:Q6PIS6 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:sdc2_human(display_long)|uniprotkb:SDC2(gene name)|psi-mi:SDC2(display_short)|uniprotkb:HSPG1(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_002989.2|reactome:R-HSA-975634|reactome:R-HSA-8957275|ensembl:ENSG00000169439(gene)|ensembl:ENST00000302190(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|mint:P34741|rcsb pdb:6ITH|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-381426|reactome:R-HSA-3928662|reactome:R-HSA-4420332|dip:DIP-29943N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:dUYGfiWzMHbYLZdV/ibV6RmeYUA9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:P28749 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-971402|uniprotkb:Q4VXA0|uniprotkb:Q8N5K6|uniprotkb:Q9H1L5|uniprotkb:Q9H1M1|uniprotkb:A8K2W5|ensembl:ENSP00000362768 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:rbl1_human(display_long)|uniprotkb:RBL1(gene name)|psi-mi:RBL1(display_short)|uniprotkb:pRb1(gene name synonym)|uniprotkb:107 kDa retinoblastoma-associated protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_002886.2|refseq:NP_899662.1|interpro:IPR002720(Retinoblastoma-associated protein, A-box)|interpro:IPR013763(Cyclin-related)|interpro:IPR015030(Rb C-terminal)|interpro:IPR024599|interpro:IPR028309|interpro:IPR028310|interpro:IPR036915|mint:P28749|rcsb pdb:1H28|rcsb pdb:4YOO|rcsb pdb:4YOS|rcsb pdb:4YOZ|rcsb pdb:5TUV|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-2173796|reactome:R-HSA-6804114|reactome:R-HSA-69205|reactome:R-HSA-69231|ensembl:ENSG00000080839(gene)|ensembl:ENST00000373664(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0043550"(regulation of lipid kinase activity)|go:"GO:0051302"(regulation of cell division)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002719(Retinoblastoma-associated protein, B-box)|dip:DIP-148N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:1tVe9Uv2ltXGbEc8qC1fNPEAYiE9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q92793 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q96IZ0 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-595869|uniprotkb:O75796|uniprotkb:Q6FHY9|uniprotkb:Q8N700|intact:EBI-2561293|ensembl:ENSP00000328088 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:pawr_human(display_long)|uniprotkb:Prostate apoptosis response 4 protein(gene name synonym)|uniprotkb:PAWR(gene name)|psi-mi:PAWR(display_short)|uniprotkb:PAR4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_002574.2|refseq:XP_016874866.1|refseq:XP_006719498.1|dip:DIP-29003N|ensembl:ENSG00000177425(gene)|ensembl:ENST00000328827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR026117|rcsb pdb:2JK9 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid://McqfeFZjywd7Ew+WWk0eCzfNw9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q09472 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-447295|intact:EBI-3908041|uniprotkb:B1AKC2|intact:EBI-28987257|ensembl:ENSP00000263253 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:ep300_human(display_long)|uniprotkb:Histone butyryltransferase p300(gene name synonym)|uniprotkb:Histone crotonyltransferase p300(gene name synonym)|uniprotkb:Protein propionyltransferase p300(gene name synonym)|uniprotkb:EP300(gene name)|psi-mi:EP300(display_short)|uniprotkb:P300(gene name synonym)|uniprotkb:E1A-associated protein p300(gene name synonym)|uniprotkb:Protein 2-hydroxyisobutyryltransferase p300(gene name synonym)|uniprotkb:Protein lactyltransferas p300(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_001420.2|ensembl:ENSP00000263253|dip:DIP-257N|go:"GO:0140068"(histone crotonyltransferase activity)|go:"GO:0140069"(histone butyryltransferase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q09472|rcsb pdb:1L3E|rcsb pdb:1P4Q|rcsb pdb:2K8F|rcsb pdb:2MH0|rcsb pdb:2MZD|rcsb pdb:3BIY|rcsb pdb:3I3J|rcsb pdb:3IO2|go:"GO:0140067"(peptidyl-lysine butyrylation)|rcsb pdb:3P57|rcsb pdb:3T92|rcsb pdb:4PZR|rcsb pdb:4PZS|rcsb pdb:4PZT|rcsb pdb:5BT3|rcsb pdb:5KJ2|rcsb pdb:5LKT|rcsb pdb:5LKU|rcsb pdb:5LKX|rcsb pdb:5LKZ|rcsb pdb:5LPK|rcsb pdb:5LPM|rcsb pdb:5NU5|rcsb pdb:5XZC|rcsb pdb:6DS6|rcsb pdb:6FGN|rcsb pdb:6FGS|rcsb pdb:6GYR|rcsb pdb:6GYT|rcsb pdb:6K4N|rcsb pdb:6PF1|rcsb pdb:6PGU|rcsb pdb:6V8B|rcsb pdb:6V8K|rcsb pdb:6V8N|rcsb pdb:6V90|rcsb pdb:7LJE|reactome:R-HSA-1234158|reactome:R-HSA-1368082|reactome:R-HSA-156711|reactome:R-HSA-1912408|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-5250924|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-5689901|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-6804758|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-8866907|reactome:R-HSA-8936459|reactome:R-HSA-8939243|reactome:R-HSA-8941856|reactome:R-HSA-8941858|reactome:R-HSA-8951936|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9031628|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|reactome:R-HSA-9616222|reactome:R-HSA-9617629|reactome:R-HSA-9707616|rcsb pdb:4BHW|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|ensembl:ENSG00000100393(gene)|ensembl:ENST00000263253(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001756"(somitogenesis)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002039"(p53 binding)|go:"GO:0002209"(behavioral defense response)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0004468"(lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030324"(lung development)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0006473"(protein acetylation)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0006915"(apoptotic process)|go:"GO:0036268"(swimming)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043627"(response to estrogen)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043969"(histone H2B acetylation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0061920"(protein propionyltransferase activity)|go:"GO:0061921"(peptidyl-lysine propionylation)|go:"GO:0090043"(regulation of tubulin deacetylation)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0106226"(peptide 2-hydroxyisobutyryltransferase activity)|go:"GO:0120301"(histone lactyltransferase activity)|go:"GO:0140065"(peptide butyryltransferase activity)|go:"GO:0140066"(peptidyl-lysine crotonylation)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:7XzMU6kWdFN0GiLox7RamD9pZeM9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77Q82 uniprotkb:Q9H0I2 intact:EBI-14062698|uniprotkb:Q2HR74 intact:EBI-744099|uniprotkb:Q6UWD7|ensembl:ENSP00000243878 psi-mi:q77q82_hhv8(display_long)|uniprotkb:vIRF(gene name)|psi-mi:vIRF(display_short)|uniprotkb:vIRF-1(gene name synonym)|uniprotkb:HHV8GK18_gp62(orf name) psi-mi:enkd1_human(display_long)|uniprotkb:ENKD1(gene name)|psi-mi:ENKD1(display_short)|uniprotkb:C16orf48(gene name synonym)|uniprotkb:UNQ6410/PRO21183(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062696|imex:IM-26114-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129411.1|rcsb pdb:4HLX|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR019471|interpro:IPR017855(SMAD domain-like)|interpro:IPR008984(SMAD/FHA domain)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|interpro:IPR036388|interpro:IPR036390 refseq:NP_115516.1|ensembl:ENSG00000124074(gene)|ensembl:ENST00000243878(transcript)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0097546"(ciliary base)|interpro:IPR027012|interpro:IPR027710|mint:Q9H0I2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:GR1vQ73Rww0U0PV79AOq+y5GMVs37296 rogid:kLnlpnGpF+sgQ+umqiN1CIK/7wc9606 rigid:bbBCjvobdvCPBXu+kEpRMzxF25o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q9UKV8 intact:EBI-14033439 intact:EBI-528269|uniprotkb:Q8TCZ5|uniprotkb:Q8WV58|uniprotkb:Q96ID1|ensembl:ENSP00000220592 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:ago2_human(display_long)|uniprotkb:AGO2(gene name)|psi-mi:AGO2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:EIF2C2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:PAZ Piwi domain protein(gene name synonym)|uniprotkb:Protein slicer(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_001158095.1|refseq:NP_036286.2|rcsb pdb:5T7B|rcsb pdb:5WEA|rcsb pdb:6CBD|rcsb pdb:6MDZ|rcsb pdb:6MFN|rcsb pdb:6MFR|rcsb pdb:6N4O|rcsb pdb:6NIT|rcsb pdb:6RA4|rcsb pdb:7C6B|rcsb pdb:7D7U|reactome:R-HSA-1912408|reactome:R-HSA-203927|reactome:R-HSA-4086398|reactome:R-HSA-426486|reactome:R-HSA-426496|reactome:R-HSA-5578749|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8934593|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|rcsb pdb:4F3T|rcsb pdb:4OLA|rcsb pdb:4OLB|rcsb pdb:4W5N|rcsb pdb:4W5O|rcsb pdb:4W5Q|rcsb pdb:4W5R|rcsb pdb:4W5T|rcsb pdb:4Z4C|rcsb pdb:4Z4D|rcsb pdb:4Z4E|rcsb pdb:4Z4F|rcsb pdb:4Z4G|rcsb pdb:4Z4H|rcsb pdb:4Z4I|rcsb pdb:5JS1|rcsb pdb:3QX9|rcsb pdb:5JS2|rcsb pdb:5KI6|ensembl:ENSG00000123908(gene)|ensembl:ENST00000220592(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9UKV8|rcsb pdb:3LUC|rcsb pdb:3LUD|rcsb pdb:3LUG|rcsb pdb:3LUH|rcsb pdb:3LUJ|rcsb pdb:3LUK|rcsb pdb:3QX8|dip:DIP-29194N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:8GU8wsz9kTG2ViT7pP7uQyYTVsc9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P52948 intact:EBI-14033439 intact:EBI-295727|uniprotkb:Q8IUT2|uniprotkb:Q8WYB0|uniprotkb:Q96E54|uniprotkb:Q9H3Q4|uniprotkb:Q9NT02|uniprotkb:Q9UF57|uniprotkb:Q9UHX0|uniprotkb:Q9Y6J4|uniprotkb:Q9Y6J5|ensembl:ENSP00000352091 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:nup98_human(display_long)|uniprotkb:NUP98(gene name)|psi-mi:NUP98(display_short)|uniprotkb:ADAR2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_005378.4|refseq:NP_057404.2|refseq:NP_624357.1|refseq:NP_624358.2|ensembl:ENST00000324932|ensembl:ENSP00000316032|ensembl:ENST00000355260|ensembl:ENSP00000347404|ensembl:ENSP00000352091|ensembl:ENST00000397004|ensembl:ENSP00000380199|ensembl:ENST00000397007|ensembl:ENSP00000380202|dip:DIP-32484N|ensembl:ENSG00000110713(gene)|ensembl:ENST00000359171(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007230(Peptidase S59, nucleoporin)|interpro:IPR021967|interpro:IPR036903|interpro:IPR037637|interpro:IPR037665|mint:P52948|rcsb pdb:1KO6|rcsb pdb:2Q5X|rcsb pdb:2Q5Y|rcsb pdb:3MMY|rcsb pdb:4OWR|rcsb pdb:5A9Q|rcsb pdb:6BZM|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:aW9NaKgLZti0wLEiVQogGukcWdE9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P35658 intact:EBI-14033439 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q9Y3E2 intact:EBI-14033439 intact:EBI-1049556|uniprotkb:Q5QNY0|uniprotkb:B2R7K2|uniprotkb:D3DUZ4|ensembl:ENSP00000358146|ensembl:ENSP00000358148|ensembl:ENSP00000358149 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:bola1_human(display_long)|uniprotkb:BOLA1(gene name)|psi-mi:BOLA1(display_short)|uniprotkb:CGI-143(orf name)|uniprotkb:hBolA(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_057158.1|ensembl:ENSG00000178096(gene)|ensembl:ENST00000369150(transcript)|ensembl:ENST00000369152(transcript)|ensembl:ENST00000369153(transcript)|go:"GO:0005739"(mitochondrion)|interpro:IPR002634(BolA-like protein)|interpro:IPR036065|mint:Q9Y3E2|rcsb pdb:5LCI|refseq:NP_001307954.1|refseq:NP_001307955.1|refseq:XP_006711411.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:zwuatrT4uNhiEo9giPSvjsyUu0w9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:O75390 intact:EBI-14033439 intact:EBI-487493|ensembl:ENSP00000342056|uniprotkb:Q71UT9|uniprotkb:Q7KZH0|uniprotkb:Q96FZ8|uniprotkb:Q9BWN8 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:cisy_human(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) go:"GO:0006101"(citrate metabolic process)|refseq:NP_004068.2|ensembl:ENSG00000062485(gene)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000351328(transcript)|rcsb pdb:5UZQ|rcsb pdb:5UZR|reactome:R-HSA-1268020|reactome:R-HSA-71403|go:"GO:0070062"(extracellular exosome)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:5UZP - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:XKpnEsGOlGRNIAXMk4tTBH2okzo9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q96EE3 intact:EBI-14033439 intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:O75592 intact:EBI-14033439 intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:O43148 intact:EBI-14033439 intact:EBI-877832|uniprotkb:D3DUJ5|uniprotkb:O94996|uniprotkb:Q9UIJ9|uniprotkb:B0YJ90|ensembl:ENSP00000262173|ensembl:ENSP00000372804|ensembl:ENSP00000446426|ensembl:ENSP00000466252 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:mces_human(display_long)|uniprotkb:RG7MT1(gene name synonym)|uniprotkb:mRNA cap methyltransferase(gene name synonym)|uniprotkb:RNMT(gene name)|psi-mi:RNMT(display_short)|uniprotkb:KIAA0398(gene name synonym)|uniprotkb:"mRNA (guanine-N(7))-methyltransferase"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_001295192.1|refseq:XP_005258219.1|refseq:NP_003790.1|refseq:XP_016881550.1|ensembl:ENSG00000101654(gene)|ensembl:ENST00000262173(transcript)|ensembl:ENST00000383314(transcript)|ensembl:ENST00000543302(transcript)|ensembl:ENST00000589866(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0031533"(mRNA cap methyltransferase complex)|go:"GO:0043235"(receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR004971(mRNA capping enzyme, large subunit)|interpro:IPR016899("mRNA (guanine-N(7))-methyltransferase")|interpro:IPR029063|interpro:IPR039753|rcsb pdb:3BGV|rcsb pdb:3EPP|rcsb pdb:5E8J|rcsb pdb:5E9J|rcsb pdb:5E9W|reactome:R-HSA-167160|reactome:R-HSA-72086|reactome:R-HSA-77075 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:DvRhHkYsM0OpIOtO/H/OtFkgkl09606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q7Z739 intact:EBI-14033439 intact:EBI-2849837|uniprotkb:Q659A3|uniprotkb:B3KXL4|uniprotkb:Q63Z37|ensembl:ENSP00000473496 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:ythd3_human(display_long)|uniprotkb:YTHDF3(gene name)|psi-mi:YTHDF3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_689971.4|refseq:NP_001264742.1|refseq:NP_001264743.1|refseq:NP_001264744.1|refseq:NP_001264745.1|refseq:NP_001264746.1|refseq:NP_001264747.1|ensembl:ENSG00000185728(gene)|ensembl:ENST00000539294(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1901163"(regulation of trophoblast cell migration)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q7Z739|rcsb pdb:6ZOT - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:M1/1RMOQiQ7kD+J9KMmEq9RZebw9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q9BYJ9 intact:EBI-14033439 intact:EBI-1051237|uniprotkb:Q8N3G5|uniprotkb:Q8TBT1|uniprotkb:Q96AN4|uniprotkb:Q96S57|uniprotkb:Q9BTI7|uniprotkb:Q9NX79|ensembl:ENSP00000359364 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:ythd1_human(display_long)|uniprotkb:Dermatomyositis associated with cancer putative autoantigen 1(gene name synonym)|uniprotkb:YTHDF1(gene name)|psi-mi:YTHDF1(display_short)|uniprotkb:C20orf21(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_060268.2|ensembl:ENSG00000149658(gene)|ensembl:ENST00000370339(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002376"(immune system process)|go:"GO:0002577"(regulation of antigen processing and presentation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q9BYJ9|rcsb pdb:4RCI|rcsb pdb:4RCJ - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:uzNKPfwF7I+6hLk6l8iiDOhuBcQ9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q99567 intact:EBI-14033439 intact:EBI-726178|uniprotkb:Q9BWE5|uniprotkb:D3DTM2|intact:EBI-28967918|ensembl:ENSP00000458954 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:nup88_human(display_long)|uniprotkb:Nucleoporin Nup88(gene name synonym)|uniprotkb:88 kDa nucleoporin(gene name synonym)|uniprotkb:NUP88(gene name)|psi-mi:NUP88(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSP00000458954|refseq:NP_002523.2|refseq:NP_001307582.1|ensembl:ENSG00000108559(gene)|ensembl:ENST00000573584(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005215"(transporter activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|interpro:IPR019321|interpro:IPR037700|mint:Q99567|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:4e7YTurNWkXUn9zj0JiD2muc94A9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P78332 intact:EBI-14033439 intact:EBI-2692323|uniprotkb:O75524|uniprotkb:O60549|uniprotkb:B4E0G6|uniprotkb:Q86SS3|ensembl:ENSP00000266022 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:rbm6_human(display_long)|uniprotkb:DEF3(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-12(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:RNA-binding motif protein 6(gene name synonym)|uniprotkb:RNA-binding protein DEF-3(gene name synonym)|uniprotkb:RBM6(gene name)|psi-mi:RBM6(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_005768.1|refseq:NP_001161054.1|refseq:XP_005264843.1|refseq:XP_005264844.1|ensembl:ENSG00000004534(gene)|ensembl:ENST00000266022(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006396"(RNA processing)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028806|interpro:IPR034123|interpro:IPR034125|interpro:IPR035617|interpro:IPR035979|interpro:IPR041591|mint:P78332|refseq:XP_016860988.1|refseq:XP_016860989.1|refseq:XP_016860990.1|refseq:XP_016860991.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:qNU439nvkG+dQNbzNI+F2JI3B049606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P78406 intact:EBI-14033439 intact:EBI-724495|uniprotkb:O15306|uniprotkb:Q3SYL7|uniprotkb:Q5TCH8|uniprotkb:Q6V708|uniprotkb:Q9H100|uniprotkb:Q9NQM6|ensembl:ENSP00000360286|ensembl:ENSP00000379181|ensembl:ENSP00000379182|uniprotkb:A8K882 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:rae1l_human(display_long)|uniprotkb:mRNA-associated protein mrnp 41(gene name synonym)|uniprotkb:Rae1 protein homolog(gene name synonym)|uniprotkb:RAE1(gene name)|psi-mi:RAE1(display_short)|uniprotkb:MRNP41(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_001015885.1|refseq:NP_003601.1|ensembl:ENSG00000101146(gene)|ensembl:ENST00000371242(transcript)|ensembl:ENST00000395840(transcript)|ensembl:ENST00000395841(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037631|mint:P78406|rcsb pdb:3MMY|rcsb pdb:4OWR|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|interpro:IPR019775|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|refseq:XP_011527390.1|refseq:XP_011527391.1|refseq:XP_005260639.2|dip:DIP-41063N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:JK4Y5p3WUcHFXBXyhhqCnDnG49c9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P37198 intact:EBI-14033439 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q9NR28 intact:EBI-14033439 intact:EBI-517508|uniprotkb:Q96LV0|uniprotkb:Q9BT11|uniprotkb:Q9HAV6|uniprotkb:B2RDQ0|ensembl:ENSP00000442360|ensembl:ENSP00000499058|uniprotkb:Q6W3F3 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:dbloh_human(display_long)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_620308.1|refseq:NP_063940.1|ensembl:ENST00000464942(transcript)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000650715(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|rcsb pdb:1FEW|dip:DIP-27627N|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1OXQ|rcsb pdb:1TW6|rcsb pdb:1XB0|rcsb pdb:1XB1|rcsb pdb:3D9U|rcsb pdb:3UIH|rcsb pdb:3UIJ|rcsb pdb:4TX5|rcsb pdb:6JX6|reactome:R-HSA-111457|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-9627069 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q9UPU5 intact:EBI-14033439 intact:EBI-1642365|uniprotkb:Q6ZSY2|uniprotkb:Q8N2Y4|uniprotkb:Q9NXD1|ensembl:ENSP00000294383 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:ubp24_human(display_long)|uniprotkb:USP24(gene name)|psi-mi:USP24(display_short)|uniprotkb:KIAA1057(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 24(gene name synonym)|uniprotkb:Deubiquitinating enzyme 24(gene name synonym)|uniprotkb:Ubiquitin thioesterase 24(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000162402(gene)|ensembl:ENST00000294383(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|refseq:NP_056121.2|interpro:IPR029071|interpro:IPR033382|mint:Q9UPU5|reactome:R-HSA-5689880|interpro:IPR038765 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:JJq+mHZKczkuP54nocU+Y9HXaQ49606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P13798 intact:EBI-14033439 intact:EBI-723792|ensembl:ENSP00000296456|uniprotkb:Q9BQ33|uniprotkb:Q9P0Y2 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:acph_human(display_long)|uniprotkb:Acyl-peptide hydrolase(gene name synonym)|uniprotkb:Acylaminoacyl-peptidase(gene name synonym)|uniprotkb:Oxidized protein hydrolase(gene name synonym)|uniprotkb:APEH(gene name)|psi-mi:APEH(display_short)|uniprotkb:D3F15S2(gene name synonym)|uniprotkb:D3S48E(gene name synonym)|uniprotkb:DNF15S2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:XP_011531962.1|refseq:NP_001631.3|ensembl:ENSG00000164062(gene)|ensembl:ENST00000296456(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006508"(proteolysis)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR029058|reactome:R-HSA-6798695|reactome:R-HSA-72764 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:vkyLSLi3WpS01GRu7YwDpq+yMsI9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:P04066 intact:EBI-14033439 intact:EBI-2512153|ensembl:ENSP00000363603|uniprotkb:Q14335|uniprotkb:Q8NAC2|uniprotkb:Q3LID0|uniprotkb:Q14334|uniprotkb:B2RBG3 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:fuco_human(display_long)|uniprotkb:FUCA1(gene name)|psi-mi:FUCA1(display_short)|uniprotkb:Alpha-L-fucoside fucohydrolase 1(gene name synonym)|uniprotkb:Alpha-L-fucosidase I(gene name synonym)|uniprotkb:Nbla10230(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000179163(gene)|ensembl:ENST00000374479(transcript)|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018526|interpro:IPR028755|interpro:IPR031919|mint:P04066|reactome:R-HSA-6798695|reactome:R-HSA-975578|refseq:NP_000138.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:hzGxBObvRAGMJxL+I9shJUo+nLg9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:O15504 intact:EBI-14033439 intact:EBI-2515057|ensembl:ENSP00000258742|uniprotkb:Q49AE7|uniprotkb:Q9BS49|uniprotkb:A4D143|uniprotkb:B4DP42|intact:EBI-13077614 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:nup42_human(display_long)|uniprotkb:NUP42(gene name)|psi-mi:NUP42(display_short)|uniprotkb:CG1(gene name synonym)|uniprotkb:NLP-1(gene name synonym)|uniprotkb:NUP42 homolog(gene name synonym)|uniprotkb:NUPL2(gene name synonym)|uniprotkb:Nucleoporin hCG1(gene name synonym)|uniprotkb:Nucleoporin-42(gene name synonym)|uniprotkb:Nucleoporin-like protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000136243(gene)|ensembl:ENST00000258742(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|interpro:IPR000571(Zinc finger, CCCH-type)|mint:O15504|rcsb pdb:6B4F|rcsb pdb:6B4I|rcsb pdb:6B4J|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-3108214|refseq:NP_031368.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:31NO/6++LYM1UsI/mSVr0bsM1to9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBS6 uniprotkb:Q96B36 intact:EBI-14033439 intact:EBI-720593|ensembl:ENSP00000341698|ensembl:ENSP00000375707|ensembl:ENSP00000375708|ensembl:ENSP00000375709|ensembl:ENSP00000375710|uniprotkb:J3KPM3|uniprotkb:Q96BI4|uniprotkb:Q96IK7|uniprotkb:Q96NG2|uniprotkb:Q9BWR5|uniprotkb:A8MTQ1|uniprotkb:B2RE93 psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:akts1_human(display_long)|uniprotkb:40 kDa proline-rich AKT substrate(gene name synonym)|uniprotkb:AKT1S1(gene name)|psi-mi:AKT1S1(display_short)|uniprotkb:PRAS40(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062727|imex:IM-26114-151 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000204673(gene)|ensembl:ENST00000344175(transcript)|ensembl:ENST00000391831(transcript)|ensembl:ENST00000391832(transcript)|ensembl:ENST00000391833(transcript)|ensembl:ENST00000391834(transcript)|refseq:NP_001092102.1|refseq:NP_001092103.1|refseq:NP_001265088.1|refseq:NP_001265089.1|refseq:NP_115751.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|interpro:IPR026682|mint:Q96B36|rcsb pdb:5WBL|rcsb pdb:5WBU|rcsb pdb:5WBY|go:"GO:0043523"(regulation of neuron apoptotic process)|rcsb pdb:6SB0|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-198323|reactome:R-HSA-3371571|reactome:R-HSA-5674400 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/07/05 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rogid:Capqfe8k0cG3E3nLJskNIEAkBfI9606 rigid:lQdQA3gITTrkPhj8AKlncD15JuY false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40917 uniprotkb:Q9HD23 intact:EBI-2608578 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 psi-mi:o40917_hhv8(display_long)|uniprotkb:ORF11(gene name)|psi-mi:ORF11(display_short)|uniprotkb:HHV8GK18_gp08(orf name) psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062752|imex:IM-26114-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:OG7cAidPXyGxKWuSTdorWqzH8Eg37296 rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 rigid:/iiCd3a2sq6GwITE3hvPwfDnW5g false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40917 uniprotkb:O00505 intact:EBI-2608578 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 psi-mi:o40917_hhv8(display_long)|uniprotkb:ORF11(gene name)|psi-mi:ORF11(display_short)|uniprotkb:HHV8GK18_gp08(orf name) psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062752|imex:IM-26114-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:OG7cAidPXyGxKWuSTdorWqzH8Eg37296 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 rigid:/iiCd3a2sq6GwITE3hvPwfDnW5g false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40917 uniprotkb:O00629 intact:EBI-2608578 intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2 psi-mi:o40917_hhv8(display_long)|uniprotkb:ORF11(gene name)|psi-mi:ORF11(display_short)|uniprotkb:HHV8GK18_gp08(orf name) psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062752|imex:IM-26114-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:OG7cAidPXyGxKWuSTdorWqzH8Eg37296 rogid:/cng/xZ42E2juzHNOpuQTP+amx89606 rigid:/iiCd3a2sq6GwITE3hvPwfDnW5g false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40917 uniprotkb:Q9UQ13 intact:EBI-2608578 intact:EBI-993879|uniprotkb:O76063|uniprotkb:A8K9W8|uniprotkb:B3KR23|uniprotkb:Q5VZS8|uniprotkb:Q5VZS9|ensembl:ENSP00000358464 psi-mi:o40917_hhv8(display_long)|uniprotkb:ORF11(gene name)|psi-mi:ORF11(display_short)|uniprotkb:HHV8GK18_gp08(orf name) psi-mi:shoc2_human(display_long)|uniprotkb:Protein soc-2 homolog(gene name synonym)|uniprotkb:SHOC2(gene name)|psi-mi:SHOC2(display_short)|uniprotkb:KIAA0862(gene name synonym)|uniprotkb:Protein sur-8 homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062752|imex:IM-26114-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006882(Herpesvirus ORF11 protein) refseq:NP_031399.2|refseq:NP_001311265.1|refseq:NP_001311266.1|refseq:NP_001255968.1|refseq:XP_016872191.1|refseq:XP_016872192.1|refseq:XP_016872193.1|ensembl:ENSG00000108061(gene)|ensembl:ENST00000369452(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027036|interpro:IPR032675|mint:Q9UQ13|reactome:R-HSA-5673000|reactome:R-HSA-9660537 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:OG7cAidPXyGxKWuSTdorWqzH8Eg37296 rogid:0RkCETF3NG59IZjnJevXVYkzBJU9606 rigid:/iiCd3a2sq6GwITE3hvPwfDnW5g false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q53GT1 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-1996072|uniprotkb:D3DX30|uniprotkb:Q96B68|uniprotkb:Q96KC6|uniprotkb:A8MTV3|uniprotkb:A8K3Q4|ensembl:ENSP00000331682|uniprotkb:B7Z2G1 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:klh22_human(display_long)|uniprotkb:KLHL22(gene name)|psi-mi:KLHL22(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_116164.2|refseq:XP_016884510.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030575|mint:Q53GT1|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000099910(gene)|ensembl:ENST00000328879(transcript) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:EC3vXSWYpde+ZCa6lm86DF+sfM89606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q5T2T1 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-2514004|ensembl:ENSP00000337907|ensembl:ENSP00000364871|ensembl:ENSP00000364884|ensembl:ENSP00000507917|uniprotkb:B2RCC9|uniprotkb:Q5T2T0|uniprotkb:B5MDZ3|uniprotkb:Q8IY28|uniprotkb:B4DWL9|uniprotkb:D3DRW3 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:mpp7_human(display_long)|uniprotkb:MPP7(gene name)|psi-mi:MPP7(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 ensembl:ENSG00000150054(gene)|ensembl:ENST00000337532(transcript)|ensembl:ENST00000375719(transcript)|ensembl:ENST00000375732(transcript)|ensembl:ENST00000683449(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071896"(protein localization to adherens junction)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035599|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q5T2T1|rcsb pdb:3LRA|rcsb pdb:3O46|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|reactome:R-HSA-9013409|reactome:R-HSA-9013423|refseq:XP_011517639.1|refseq:NP_001305099.1|refseq:NP_775767.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:QYVCkD5zsnTsCd7YsYsbQY8L7fU9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q969S3 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-2687480|ensembl:ENSP00000310042 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:zn622_human(display_long)|uniprotkb:ZPR9(gene name synonym)|uniprotkb:Zinc finger-like protein 9(gene name synonym)|uniprotkb:ZNF622(gene name)|psi-mi:ZNF622(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_219482.1|ensembl:ENSG00000173545(gene)|ensembl:ENST00000308683(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR022755|interpro:IPR036236|interpro:IPR040025|interpro:IPR041661|mint:Q969S3|rcsb pdb:6LQM|rcsb pdb:6LSR - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:WUzJA1E/Gz78ud7PgHYxKxUSvU49606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q13618 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:xI/8pHB9nckOW629STOqKba4KzQ9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q9P2J3 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q9H4A6 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q9H4A5 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-4403434|uniprotkb:B7Z6N3|uniprotkb:B1AN09|uniprotkb:Q9NVK0|ensembl:ENSP00000271732 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:glp3l_human(display_long)|uniprotkb:GOLPH3L(gene name)|psi-mi:GOLPH3L(display_short)|uniprotkb:GPP34R(gene name synonym)|uniprotkb:GPP34-related protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_060648.2|ensembl:ENSG00000143457(gene)|ensembl:ENST00000271732(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A5 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:E+0Ru85nv0KoO/LW0kZLN1vpbFc9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI8 uniprotkb:Q9NW15 intact:EBI-14062763|uniprotkb:Q2HRB7 intact:EBI-11349452|uniprotkb:B7WP12|uniprotkb:A8K8K3|uniprotkb:Q8IXX9|uniprotkb:C9JHS1|uniprotkb:B4DNK2|uniprotkb:B3KY93|uniprotkb:B4DJ83|uniprotkb:B3KTZ1|uniprotkb:A8MV74|ensembl:ENSP00000292246 psi-mi:q76ri8_hhv8(display_long)|uniprotkb:ORF16(gene name)|psi-mi:ORF16(display_short)|uniprotkb:HHV8GK18_gp19(orf name) psi-mi:ano10_human(display_long)|uniprotkb:ANO10(gene name)|psi-mi:ANO10(display_short)|uniprotkb:TMEM16K(gene name synonym)|uniprotkb:Transmembrane protein 16K(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062761|imex:IM-26114-129 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0033668"(negative regulation by symbiont of host apoptotic process)|interpro:IPR036834|refseq:YP_001129368.1|rcsb pdb:1K3K|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298 refseq:NP_001191760.1|refseq:NP_001191761.1|refseq:NP_001191762.1|refseq:NP_001191763.1|refseq:NP_060545.3|refseq:NP_001333392.1|refseq:NP_001333393.1|refseq:NP_001333394.1|refseq:NP_001333395.1|refseq:NP_001333396.1|refseq:NP_001333397.1|refseq:NP_001333398.1|refseq:XP_016862211.1|ensembl:ENSG00000160746(gene)|ensembl:ENST00000292246(transcript)|go:"GO:0005227"(calcium activated cation channel activity)|go:"GO:0005229"(intracellular calcium activated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006821"(chloride transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055085"(transmembrane transport)|interpro:IPR007632(Protein of unknown function DUF590)|interpro:IPR031291|rcsb pdb:5OC9|rcsb pdb:6R65|rcsb pdb:6R7X|rcsb pdb:6R7Y|rcsb pdb:6R7Z|reactome:R-HSA-2672351 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:W3jDI6xAFUNPa6+oSng0mOgLTSA37296 rogid:XRfkrBqltkpquCUp5CyaWn7pKJo9606 rigid:WPil2lCgdbTeaN5tlXz+LH+ynec false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBT9 uniprotkb:Q9NZC7 intact:EBI-14033452 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062785|imex:IM-26114-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 rigid:JIAKoWWCk+Q+MegZhcDOURVnoe0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBT9 uniprotkb:P52294 intact:EBI-14033452 intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93 psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062785|imex:IM-26114-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606 rigid:JIAKoWWCk+Q+MegZhcDOURVnoe0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBT9 uniprotkb:O15131 intact:EBI-14033452 intact:EBI-540602|uniprotkb:Q86X23|uniprotkb:B2RAI5|ensembl:ENSP00000348704|ensembl:ENSP00000357552 psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:ima6_human(display_long)|uniprotkb:Karyopherin subunit alpha-5(gene name synonym)|uniprotkb:KPNA5(gene name)|psi-mi:KPNA5(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062785|imex:IM-26114-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 refseq:NP_002260.2|reactome:R-HSA-1169408|reactome:R-HSA-168276|rcsb pdb:4U2X|ensembl:ENSG00000196911(gene)|ensembl:ENST00000356348(transcript)|ensembl:ENST00000368564(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O15131|refseq:XP_016866328.1|refseq:XP_016866329.1|dip:DIP-33405N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rogid:ixGSmHZKndxkY0NFF1Adu+7SmEA9606 rigid:JIAKoWWCk+Q+MegZhcDOURVnoe0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBT9 uniprotkb:O60684 intact:EBI-14033452 intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5 psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062785|imex:IM-26114-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606 rigid:JIAKoWWCk+Q+MegZhcDOURVnoe0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBT9 uniprotkb:Q9UIL1 intact:EBI-14033452 intact:EBI-2686537|uniprotkb:Q7L2Y0|uniprotkb:Q9BZB2|uniprotkb:Q96JY9|uniprotkb:Q7Z4P2|uniprotkb:B7WPH7|uniprotkb:Q6P5T9|intact:EBI-2812448|uniprotkb:D3DNY7|uniprotkb:E9PB65 psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:scoc_human(display_long)|uniprotkb:SCOCO(gene name synonym)|uniprotkb:HRIHFB2072(orf name)|uniprotkb:SCOC(gene name)|psi-mi:SCOC(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062785|imex:IM-26114-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 refseq:NP_001146918.1|refseq:NP_001146956.1|refseq:NP_001147024.1|refseq:NP_001147057.1|refseq:NP_001147107.1|refseq:NP_001147135.1|refseq:NP_001147162.1|refseq:NP_115936.2|interpro:IPR019357|reactome:R-HSA-6811440|rcsb pdb:4BWD|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0000139"(Golgi membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rogid:l1hHXnWtTNJbZZBNyDtExzt5SSQ9606 rigid:JIAKoWWCk+Q+MegZhcDOURVnoe0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:Q96LA8 intact:EBI-14062797 intact:EBI-912440|uniprotkb:Q5T5Y5|uniprotkb:Q6DKI4|uniprotkb:Q9NVR8|uniprotkb:A3KME1|uniprotkb:B4DID8|ensembl:ENSP00000359095 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:anm6_human(display_long)|uniprotkb:Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6(gene name synonym)|uniprotkb:PRMT6(gene name)|psi-mi:PRMT6(display_short)|uniprotkb:HRMT1L6(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_060607.2|ensembl:ENSG00000198890(gene)|ensembl:ENST00000370078(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0019919"(peptidyl-arginine methylation, to asymmetrical-dimethyl arginine)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042393"(histone binding)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0070611"("histone methyltransferase activity (H3-R2 specific)")|go:"GO:0070612"("histone methyltransferase activity (H2A-R3 specific)")|go:"GO:0090398"(cellular senescence)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q96LA8|rcsb pdb:4HC4|rcsb pdb:4QPP|rcsb pdb:4QQK|rcsb pdb:4Y2H|rcsb pdb:4Y30|rcsb pdb:5E8R|rcsb pdb:5EGS|rcsb pdb:5HZM|rcsb pdb:5WCF|rcsb pdb:6P7I|rcsb pdb:6W6D|rcsb pdb:6WAD|rcsb pdb:7NR4|reactome:R-HSA-3214858|reactome:R-HSA-8936459 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:0c6pV8lui9y+iXrlrOvxWjEZMf49606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:O60547 intact:EBI-14062797 intact:EBI-746373|uniprotkb:O75357|uniprotkb:Q5T954|uniprotkb:Q6FH09|uniprotkb:Q9UGZ3|uniprotkb:Q9UJK9|ensembl:ENSP00000370194|intact:EBI-10968896|uniprotkb:E9PI88 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:gmds_human(display_long)|uniprotkb:GDP-D-mannose dehydratase(gene name synonym)|uniprotkb:GMDS(gene name)|psi-mi:GMDS(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_001491.1|ensembl:ENSG00000112699(gene)|ensembl:ENST00000380815(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008446"(GDP-mannose 4,6-dehydratase activity)|go:"GO:0019673"(GDP-mannose metabolic process)|go:"GO:0042351"('de novo' GDP-L-fucose biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070401"(NADP+ binding)|interpro:IPR006368(GDP-mannose 4,6-dehydratase)|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1T2A|rcsb pdb:5IN4|rcsb pdb:5IN5|rcsb pdb:6GPJ|rcsb pdb:6GPK|rcsb pdb:6GPL|rcsb pdb:6Q94|reactome:R-HSA-6787639|refseq:NP_001240775.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:phGw3/m75gYQcBlRP3OXK4mQvhM9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:O00308 intact:EBI-14062797 intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:P07093 intact:EBI-14062797 intact:EBI-10195168|ensembl:ENSP00000258405|uniprotkb:Q5D0C4|uniprotkb:B2R6A4|uniprotkb:Q53S15|uniprotkb:B4DIF2 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:gdn_human(display_long)|uniprotkb:SERPINE2(gene name)|psi-mi:SERPINE2(display_short)|uniprotkb:PI7(gene name synonym)|uniprotkb:PN1(gene name synonym)|uniprotkb:Peptidase inhibitor 7(gene name synonym)|uniprotkb:Protease nexin 1(gene name synonym)|uniprotkb:Protease nexin I(gene name synonym)|uniprotkb:Serpin E2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 ensembl:ENSG00000135919(gene)|ensembl:ENST00000258405(transcript)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|refseq:NP_001130000.1|refseq:NP_001130002.1|refseq:NP_006207.1|refseq:XP_016859818.1|refseq:XP_016859819.1|refseq:XP_016859821.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0021683"(cerebellar granular layer morphogenesis)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032940"(secretion by cell)|go:"GO:0033363"(secretory granule organization)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042628"(mating plug formation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0061108"(seminal vesicle epithelium development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042185|rcsb pdb:4DY0|rcsb pdb:4DY7|reactome:R-HSA-140837|reactome:R-HSA-140875|reactome:R-HSA-75205|interpro:IPR042178|refseq:XP_016859820.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:/bldmCPraMzS/9fpQs7Xxx2xoQU9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:P14735 intact:EBI-14062797 intact:EBI-2556886|uniprotkb:Q5T5N2|uniprotkb:D3DR35|ensembl:ENSP00000265986|uniprotkb:B2R721|uniprotkb:B7ZAU2 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:ide_human(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)|uniprotkb:Abeta-degrading protease(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_004960.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0043559"(insulin binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:P14735|rcsb pdb:2G47|rcsb pdb:2G48|rcsb pdb:2G49|rcsb pdb:2G54|rcsb pdb:2G56|rcsb pdb:2JBU|rcsb pdb:2JG4|rcsb pdb:2WBY|rcsb pdb:2WC0|rcsb pdb:2WK3|rcsb pdb:2YPU|rcsb pdb:3CWW|rcsb pdb:3E4A|rcsb pdb:3E4Z|rcsb pdb:3E50|rcsb pdb:3H44|rcsb pdb:3N56|rcsb pdb:3N57|rcsb pdb:3OFI|rcsb pdb:3QZ2|rcsb pdb:4DTT|rcsb pdb:4DWK|rcsb pdb:4GS8|rcsb pdb:4GSC|rcsb pdb:4GSF|rcsb pdb:4IFH|rcsb pdb:4IOF|rcsb pdb:4LTE|rcsb pdb:4M1C|rcsb pdb:4NXO|rcsb pdb:4PES|rcsb pdb:4PF7|rcsb pdb:4PF9|rcsb pdb:4PFC|rcsb pdb:4QIA|rcsb pdb:4RAL|rcsb pdb:4RE9|rcsb pdb:5CJO|rcsb pdb:3HGZ|rcsb pdb:5UOE|rcsb pdb:5WOB|rcsb pdb:6B3Q|rcsb pdb:6B70|rcsb pdb:6B7Y|rcsb pdb:6BF6|rcsb pdb:6BF7|rcsb pdb:6BF8|rcsb pdb:6BF9|rcsb pdb:6BFC|rcsb pdb:6BYZ|rcsb pdb:6EDS|rcsb pdb:6MQ3|reactome:R-HSA-5689880|reactome:R-HSA-9033241|rcsb pdb:6B7Z|refseq:NP_001159418.1|dip:DIP-55771N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:dwngN3kUOExC5qapSgF01YhBNAM9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:Q13438 intact:EBI-14062797 intact:EBI-725454|intact:EBI-1174342|uniprotkb:A6NDD1|uniprotkb:A6NFR7|uniprotkb:A6NLB2|uniprotkb:A8K5Q9|uniprotkb:B4DPX1|uniprotkb:B4E1I6|uniprotkb:E7ENT8|uniprotkb:F8VUH2|uniprotkb:O00579|uniprotkb:Q6IBL2|uniprotkb:Q8IZ58|uniprotkb:Q9BW99|uniprotkb:B4DE28|ensembl:ENSP00000318165|uniprotkb:E7EW91|uniprotkb:G3XA88 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:os9_human(display_long)|uniprotkb:OS9(gene name)|psi-mi:OS9(display_short)|uniprotkb:Amplified in osteosarcoma 9(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_006803.1|refseq:NP_001017956.1|refseq:NP_001017957.1|refseq:NP_001017958.1|refseq:NP_001248349.1|refseq:NP_001248350.1|refseq:NP_001248351.1|refseq:NP_001248352.1|ensembl:ENSG00000135506(gene)|ensembl:ENST00000315970(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0002020"(protease binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006605"(protein targeting)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|interpro:IPR044865|rcsb pdb:3AIH|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-37493N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:Ntc3geE7th+rBeIp0MxuUuu/28Y9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:Q9H0M0 intact:EBI-14062797 intact:EBI-742157|uniprotkb:O00307|uniprotkb:Q96BP4|ensembl:ENSP00000265428|ensembl:ENSP00000427793|uniprotkb:Q5YLC1 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:wwp1_human(display_long)|uniprotkb:WWP1(gene name)|psi-mi:WWP1(display_short)|uniprotkb:WW domain-containing protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 5(gene name synonym)|uniprotkb:TGIF-interacting ubiquitin ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase WWP1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_008944.1|interpro:IPR035892|go:"GO:0045732"(positive regulation of protein catabolic process)|interpro:IPR035983|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR036020|mint:Q9H0M0|rcsb pdb:1ND7|rcsb pdb:2OP7|rcsb pdb:5HPS|rcsb pdb:5HPT|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|rcsb pdb:6J1X|rcsb pdb:6J1Y|reactome:R-HSA-1253288|reactome:R-HSA-2672351|reactome:R-HSA-8939902|reactome:R-HSA-983168|interpro:IPR024928|ensembl:ENSG00000123124(gene)|ensembl:ENST00000265428(transcript)|ensembl:ENST00000517970(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007417"(central nervous system development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_005250817.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:a+aRHHhwu3pCkmlkDNqcN1PJ7LI9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:O15131 intact:EBI-14062797 intact:EBI-540602|uniprotkb:Q86X23|uniprotkb:B2RAI5|ensembl:ENSP00000348704|ensembl:ENSP00000357552 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:ima6_human(display_long)|uniprotkb:Karyopherin subunit alpha-5(gene name synonym)|uniprotkb:KPNA5(gene name)|psi-mi:KPNA5(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_002260.2|reactome:R-HSA-1169408|reactome:R-HSA-168276|rcsb pdb:4U2X|ensembl:ENSG00000196911(gene)|ensembl:ENST00000356348(transcript)|ensembl:ENST00000368564(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O15131|refseq:XP_016866328.1|refseq:XP_016866329.1|dip:DIP-33405N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:ixGSmHZKndxkY0NFF1Adu+7SmEA9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:Q9UIL1 intact:EBI-14062797 intact:EBI-2686537|uniprotkb:Q7L2Y0|uniprotkb:Q9BZB2|uniprotkb:Q96JY9|uniprotkb:Q7Z4P2|uniprotkb:B7WPH7|uniprotkb:Q6P5T9|intact:EBI-2812448|uniprotkb:D3DNY7|uniprotkb:E9PB65 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:scoc_human(display_long)|uniprotkb:SCOCO(gene name synonym)|uniprotkb:HRIHFB2072(orf name)|uniprotkb:SCOC(gene name)|psi-mi:SCOC(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_001146918.1|refseq:NP_001146956.1|refseq:NP_001147024.1|refseq:NP_001147057.1|refseq:NP_001147107.1|refseq:NP_001147135.1|refseq:NP_001147162.1|refseq:NP_115936.2|interpro:IPR019357|reactome:R-HSA-6811440|rcsb pdb:4BWD|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0000139"(Golgi membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:l1hHXnWtTNJbZZBNyDtExzt5SSQ9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:P52294 intact:EBI-14062797 intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:O60684 intact:EBI-14062797 intact:EBI-359923|uniprotkb:Q5VVU3|uniprotkb:B2RDC7|ensembl:ENSP00000362728|uniprotkb:D3DPP5 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:ima7_human(display_long)|uniprotkb:KPNA6(gene name)|psi-mi:KPNA6(display_short)|uniprotkb:IPOA7(gene name synonym)|uniprotkb:Karyopherin subunit alpha-6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_036448.1|ensembl:ENSG00000025800(gene)|ensembl:ENST00000373625(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O60684|rcsb pdb:4UAD|dip:DIP-27609N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:3NsSIcE6BHIqYlvfGRolUKD/5uc9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HE15 uniprotkb:Q9NZC7 intact:EBI-14062797 intact:EBI-4320739|uniprotkb:A8K323|uniprotkb:Q5MYT5|uniprotkb:Q96KM3|uniprotkb:Q96RF2|uniprotkb:Q9BTT8|uniprotkb:Q9NPC9|uniprotkb:Q9NRF4|uniprotkb:Q9NRF5|uniprotkb:Q9NRF6|uniprotkb:Q9NRK1|uniprotkb:Q9NZC5|ensembl:ENSP00000457230 psi-mi:f5he15_hhv8(display_long)|uniprotkb:ORF17.5(gene name)|psi-mi:ORF17.5(display_short)|uniprotkb:HHV8GK18_gp21(orf name) psi-mi:wwox_human(display_long)|uniprotkb:WWOX(gene name)|psi-mi:WWOX(display_short)|uniprotkb:FOR(gene name synonym)|uniprotkb:WOX1(gene name synonym)|uniprotkb:Fragile site FRA16D oxidoreductase(gene name synonym)|uniprotkb:SDR41C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 41C member 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062795|imex:IM-26114-153 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129370.1 refseq:NP_057457.1|refseq:NP_570607.1|refseq:NP_001278926.1|ensembl:ENST00000566780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036020|interpro:IPR036291|interpro:IPR042732|mint:Q9NZC7|rcsb pdb:1WMV|reactome:R-HSA-1251985|reactome:R-HSA-8866904|reactome:R-HSA-8866907|ensembl:ENSG00000186153(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:889lXj1kiffIvdHwu1yPoSPHpvI37296 rogid:YMGESSlld4QIPoFrcPX3zhwIy2E9606 rigid:5RsjLERLiJfipiI2eRKusNNj3Fo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:Q13162 intact:EBI-14032793 intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:Q07666 intact:EBI-14032793 intact:EBI-1364|uniprotkb:Q6PJX7|uniprotkb:Q8NB97|uniprotkb:Q99760|uniprotkb:D3DPP3|ensembl:ENSP00000313829 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:khdr1_human(display_long)|uniprotkb:SAM68(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:KHDRBS1(gene name)|psi-mi:KHDRBS1(display_short)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:p68(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_006550.1|refseq:NP_001258807.1|dip:DIP-29007N|ensembl:ENSG00000121774(gene)|ensembl:ENST00000327300(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q07666|rcsb pdb:2XA6|rcsb pdb:3QHE|reactome:R-HSA-8849468 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:po7jC4Nxu+Aoz6T8K6VRWHp6MKQ9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:P63151 intact:EBI-14032793 intact:EBI-1048931|uniprotkb:P50409|uniprotkb:Q00007|uniprotkb:B2RBU8|intact:EBI-2556013|uniprotkb:B4E1T7|ensembl:ENSP00000370113 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:2aba_human(display_long)|uniprotkb:PPP2R2A(gene name)|psi-mi:PPP2R2A(display_short)|uniprotkb:PP2A subunit B isoform alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-alpha(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-alpha(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_001171062.1|refseq:NP_002708.1|ensembl:ENSG00000221914(gene)|ensembl:ENST00000380737(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0043278"(response to morphine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:P63151|rcsb pdb:3DW8|reactome:R-HSA-2995383|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-975957|dip:DIP-29398N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:evS6klM2alZXtMthVsshKkrNgiA9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:P22234 intact:EBI-14032793 intact:EBI-712261|ensembl:ENSP00000264221|ensembl:ENSP00000421096|uniprotkb:E9PDH9|uniprotkb:Q68CQ5|intact:EBI-21352784 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:pur6_human(display_long)|uniprotkb:PAICS(gene name)|psi-mi:PAICS(display_short)|uniprotkb:ADE2(gene name synonym)|uniprotkb:AIRC(gene name synonym)|uniprotkb:PAIS(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) ensembl:ENSG00000128050(gene)|ensembl:ENST00000264221(transcript)|ensembl:ENST00000512576(transcript)|go:"GO:0004639"(phosphoribosylaminoimidazolesuccinocarboxamide synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043727"(5-amino-4-imidazole carboxylate lyase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000031("1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase")|interpro:IPR018236|interpro:IPR028923|interpro:IPR033626|mint:P22234|rcsb pdb:2H31|rcsb pdb:6YB8|go:"GO:0004638"(phosphoribosylaminoimidazole carboxylase activity)|rcsb pdb:6YB9|reactome:R-HSA-73817|refseq:NP_001072992.1|refseq:NP_001072993.1|refseq:NP_006443.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:aR4Xj14ZQrPiY8cldw5o9AvjkAo9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:O60678 intact:EBI-14032793 intact:EBI-2809009|uniprotkb:B4DUC7|uniprotkb:A0A0A0MSN7|ensembl:ENSP00000331879 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:anm3_human(display_long)|uniprotkb:PRMT3(gene name)|psi-mi:PRMT3(display_short)|uniprotkb:HRMT1L3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_005779.1|ensembl:ENSG00000185238(gene)|ensembl:ENST00000331079(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1900053"(negative regulation of retinoic acid biosynthetic process)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR036236|mint:O60678|rcsb pdb:2FYT|rcsb pdb:3SMQ|rcsb pdb:4HSG|rcsb pdb:4QQN|rcsb pdb:4RYL|reactome:R-HSA-3214858|reactome:R-HSA-8876725 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:XtFHON3qMCvjDhtN8RpXJo9KODU9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:Q9H5V9 intact:EBI-14032793 intact:EBI-1053419|uniprotkb:A8MPX7|uniprotkb:B4DQN2|uniprotkb:F5GWL7|uniprotkb:O43351|uniprotkb:D3DWH9|ensembl:ENSP00000494123 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:steep_human(display_long)|uniprotkb:STEEP1(gene name)|psi-mi:STEEP1(display_short)|uniprotkb:CXorf56(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_001164040.1|refseq:NP_001164041.1|refseq:NP_071384.1|ensembl:ENSG00000018610(gene)|ensembl:ENST00000644802(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0044297"(cell body)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR029704 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:24LR5Wy5GnADosh247l7Yqfr4aQ9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:Q96C92 intact:EBI-14032793 intact:EBI-717093|uniprotkb:A6NCP1|uniprotkb:O60525|uniprotkb:Q5SXN1|uniprotkb:Q5SXN2|uniprotkb:Q5SXN3|uniprotkb:Q5SXN4|uniprotkb:Q5SXN8|uniprotkb:Q9NVY5|uniprotkb:Q6V704|ensembl:ENSP00000349929 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:entr1_human(display_long)|uniprotkb:ENTR1(gene name)|psi-mi:ENTR1(display_short)|uniprotkb:Antigen NY-CO-3(gene name synonym)|uniprotkb:SDCCAG3(gene name synonym)|uniprotkb:Serologically defined colon cancer antigen 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_001034796.1|refseq:NP_001034797.1|refseq:NP_006634.3|ensembl:ENSG00000165689(gene)|ensembl:ENST00000357365(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0007049"(cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR026757 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:DSgzbp57wLtRY2EX7zoT5jNuTrI9606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76S40 uniprotkb:Q66LE6 intact:EBI-14032793 intact:EBI-717262|uniprotkb:A8KAK0|uniprotkb:Q5SQJ2|uniprotkb:Q9P1Y7|intact:EBI-2556023|ensembl:ENSP00000399970 psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:2abd_human(display_long)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PPP2R2D(gene name)|psi-mi:PPP2R2D(display_short)|uniprotkb:KIAA1541(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062817|imex:IM-26114-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) refseq:NP_060931.2|ensembl:ENSG00000175470(gene)|ensembl:ENST00000455566(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q66LE6|reactome:R-HSA-2465910|refseq:NP_001278239.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rogid:rqczFHaYgyv+qEbwD4SjcdXrjR49606 rigid:YTcVmotwS7PJW7YlhFPQLkH6feo false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9H6F5 uniprotkb:E5LBU3 intact:EBI-721289|uniprotkb:B4DY99|ensembl:ENSP00000227520 intact:EBI-14062832 psi-mi:ccd86_human(display_long)|uniprotkb:Cytokine-induced protein with coiled-coil domain(gene name synonym)|uniprotkb:CYCLON(gene name synonym)|uniprotkb:CCDC86(gene name)|psi-mi:CCDC86(display_short) psi-mi:e5lbu3_hhv8(display_long)|uniprotkb:ORF20(gene name)|psi-mi:ORF20(display_short)|uniprotkb:ORF19(gene name synonym)|uniprotkb:HHV8GK18_gp23(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062830|imex:IM-26114-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077003.1|ensembl:ENSG00000110104(gene)|ensembl:ENST00000227520(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|interpro:IPR005579(Cgr1)|interpro:IPR026570|mint:Q9H6F5 refseq:YP_001129373.1|interpro:IPR002580(Herpes virus protein UL24) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:dRd5UWPzAehh8OFqkWrMMCnYYug9606 rogid:x5PAFunLaCnccuQpLIrOHeX4p+c37296 rigid:I4lHs2QRhhKS9Slmf9YLgdK1I/o false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q5SYE7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-9640051|uniprotkb:Q5SYE8|uniprotkb:Q3ZCS5|uniprotkb:Q9P2J0|ensembl:ENSP00000394546 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:nhsl1_human(display_long)|uniprotkb:NHSL1(gene name)|psi-mi:NHSL1(display_short)|uniprotkb:C6orf63(gene name synonym)|uniprotkb:KIAA1357(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENST00000343505|ensembl:ENSP00000344672|ensembl:ENSP00000394546|refseq:NP_001137532.1|refseq:NP_065197.1|dip:DIP-47303N|ensembl:ENSG00000135540(gene)|ensembl:ENST00000427025(transcript)|go:"GO:0030154"(cell differentiation)|interpro:IPR024845|mint:Q5SYE7 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:fSt25Mtm6KgIdpf9rD+jhzp4rqo9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9UKF6 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1044699|uniprotkb:O14769|uniprotkb:Q96F36|uniprotkb:Q53RS2|ensembl:ENSP00000238112 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:cpsf3_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 73 kDa subunit(gene name synonym)|uniprotkb:mRNA 3'-end-processing endonuclease CPSF-73(gene name synonym)|uniprotkb:CPSF3(gene name)|psi-mi:CPSF3(display_short)|uniprotkb:CPSF73(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_057291.1|ensembl:ENSG00000119203(gene)|ensembl:ENST00000238112(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|interpro:IPR021718|interpro:IPR022712|interpro:IPR036866|mint:Q9UKF6|rcsb pdb:2I7T|rcsb pdb:2I7V|rcsb pdb:6M8Q|rcsb pdb:6V4X|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|dip:DIP-42501N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:lpTAUhlcFjFt2tHErN9igCjWTzs9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q02809 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-357174|ensembl:ENSP00000196061|uniprotkb:Q96AV9|uniprotkb:Q9H132|uniprotkb:B4DR87|intact:EBI-21357524 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:plod1_human(display_long)|uniprotkb:PLOD(gene name synonym)|uniprotkb:PLOD1(gene name)|psi-mi:PLOD1(display_short)|uniprotkb:LLH(gene name synonym)|uniprotkb:Lysyl hydroxylase 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000083444(gene)|ensembl:ENST00000196061(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902494"(catalytic complex)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR029044|mint:Q02809|reactome:R-HSA-1650814|refseq:NP_000293.2|refseq:NP_001303249.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:q0eJHb8L3qTbN1PnjQ8L0PcpOLw9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9NXV2 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1056857|uniprotkb:D3DU96|ensembl:ENSP00000301738 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:kctd5_human(display_long)|uniprotkb:KCTD5(gene name)|psi-mi:KCTD5(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_061865.1|interpro:IPR011333(BTB/POZ fold)|mint:Q9NXV2|rcsb pdb:3DRX|rcsb pdb:3DRY|rcsb pdb:3DRZ|ensembl:ENSG00000167977(gene)|ensembl:ENST00000301738(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:KzXA4jgTKUY/EE1ORX+nMLCPfro9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9NQH7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1171467|uniprotkb:Q6I9V9|uniprotkb:Q8NDA6|uniprotkb:Q9BV27|uniprotkb:Q9BVH0|uniprotkb:B7Z790|uniprotkb:B7Z7B2|uniprotkb:B2R9G1|intact:EBI-2562323|ensembl:ENSP00000349658 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:xpp3_human(display_long)|uniprotkb:Aminopeptidase P3(gene name synonym)|uniprotkb:XPNPEP3(gene name)|psi-mi:XPNPEP3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_071381.1|ensembl:ENSG00000196236(gene)|ensembl:ENST00000357137(transcript)|go:"GO:0003094"(glomerular filtration)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016485"(protein processing)|go:"GO:0030145"(manganese ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070006"(metalloaminopeptidase activity)|interpro:IPR007865(Peptidase M24B, X-Pro dipeptidase/aminopeptidase P N-terminal)|interpro:IPR029149|interpro:IPR036005|rcsb pdb:5X49|interpro:IPR000994(Peptidase M24, catalytic core) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:hRjwsoqTVtJ1YTaVzYWomQGmJOE9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q14681 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-2556480|ensembl:ENSP00000312814 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:kctd2_human(display_long)|uniprotkb:Potassium channel tetramerization domain-containing protein 2(gene name synonym)|uniprotkb:KIAA0176(gene name synonym)|uniprotkb:KCTD2(gene name)|psi-mi:KCTD2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_056168.1|ensembl:ENSG00000180901(gene)|ensembl:ENST00000322444(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:haz8y1ey8Z+TaMeIsI2kyTetnLs9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9C0J8 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-712637|uniprotkb:Q6NUQ0|uniprotkb:Q587J1|uniprotkb:Q05DP8|uniprotkb:Q53FG9|uniprotkb:Q9NUL1|uniprotkb:Q69YF7|ensembl:ENSP00000325377 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:wdr33_human(display_long)|uniprotkb:WDR33(gene name)|psi-mi:WDR33(display_short)|uniprotkb:WDC146(gene name synonym)|uniprotkb:WD repeat-containing protein 33(gene name synonym)|uniprotkb:WD repeat-containing protein of 146 kDa(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:XP_011509738.1|refseq:NP_001006623.1|refseq:NP_060853.3|refseq:NP_001006624.1|ensembl:ENSG00000136709(gene)|ensembl:ENST00000322313(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005581"(collagen trimer)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006301"(postreplication repair)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007283"(spermatogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9C0J8|rcsb pdb:6BLY|rcsb pdb:6BM0|rcsb pdb:6DNH|rcsb pdb:6F9N|rcsb pdb:6FBS|rcsb pdb:6FUW|rcsb pdb:6URG|rcsb pdb:6URO|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:FzGeASJyKaYaqFQfFBYby692REg9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q93008 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-302524|intact:EBI-1058656|intact:EBI-28978998|ensembl:ENSP00000367558|uniprotkb:O75550|uniprotkb:Q8WWT3|uniprotkb:Q8WX12 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:usp9x_human(display_long)|uniprotkb:USP9X(gene name)|psi-mi:USP9X(display_short)|uniprotkb:DFFRX(gene name synonym)|uniprotkb:USP9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:FAM(gene name synonym)|uniprotkb:Fat facets in mammals(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000124486(gene)|ensembl:ENST00000378308(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007292"(female gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-2173795|reactome:R-HSA-5689880|reactome:R-HSA-8866652|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9033241|reactome:R-HSA-977225|go:"GO:0048675"(axon extension)|refseq:NP_001034679.2|refseq:NP_001034680.2|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR031226|interpro:IPR038765|mint:Q93008|rcsb pdb:5VBD|rcsb pdb:5WCH|ensembl:ENST00000324545|ensembl:ENSP00000316357|ensembl:ENSP00000367558|dip:DIP-27562N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:f9AWz8rAV8rMTqcQ46VrYYLTHq89606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9Y2W1 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-352039|uniprotkb:Q5VTK6|uniprotkb:D3DPS5|ensembl:ENSP00000346634|ensembl:ENSP00000433825 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:tr150_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 2(gene name synonym)|uniprotkb:BCLAF2(gene name synonym)|uniprotkb:THRAP3(gene name)|psi-mi:THRAP3(display_short)|uniprotkb:TRAP150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_005110.2|ensembl:ENSG00000054118(gene)|ensembl:ENST00000354618(transcript)|ensembl:ENST00000469141(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026667|interpro:IPR029199|mint:Q9Y2W1|reactome:R-HSA-1989781|reactome:R-HSA-381340|refseq:NP_001308400.1|refseq:NP_001308402.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:pPyZVG1IXg/+QDpHngwzUX09cBM9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q06190 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-949190|ensembl:ENSP00000264977|uniprotkb:Q06189|uniprotkb:Q9NPQ5|uniprotkb:A8KAE7|uniprotkb:B7ZAE3|uniprotkb:B4DNU1 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:p2r3a_human(display_long)|uniprotkb:PPP2R3A(gene name)|psi-mi:PPP2R3A(display_short)|uniprotkb:PPP2R3(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B(gene name synonym)|uniprotkb:PP2A subunit B isoforms B''-PR72/PR130(gene name synonym)|uniprotkb:PP2A subunit B isoforms B72/B130(gene name synonym)|uniprotkb:PP2A subunit B isoform PR72/PR130(gene name synonym)|uniprotkb:PP2A subunit B isoform R3 isoform(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000073711(gene)|ensembl:ENST00000264977(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007525"(somatic muscle development)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061053"(somite development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090249"(regulation of cell migration involved in somitogenic axis elongation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR041534|mint:Q06190|rcsb pdb:4I5J|rcsb pdb:4I5K|refseq:XP_006713749.1|dip:DIP-29397N|refseq:NP_001177376.1|refseq:NP_002709.2|refseq:NP_871626.1|refseq:XP_011511258.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:JUs8mW7xbB1i6e6vYMBfXFupA389606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q16630 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-358410|uniprotkb:Q53ES1|uniprotkb:Q9BSJ7|uniprotkb:Q9BW18|intact:EBI-740029|uniprotkb:A8K7K9|ensembl:ENSP00000391774 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:cpsf6_human(display_long)|uniprotkb:CPSF6(gene name)|psi-mi:CPSF6(display_short)|uniprotkb:CFIM68(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 68 kDa subunit(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym)|uniprotkb:Protein HPBRII-4/7(gene name synonym)|uniprotkb:Cleavage factor Im complex 68 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_008938.2|refseq:NP_001287876.1|ensembl:ENSG00000111605(gene)|ensembl:ENST00000435070(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042382"(paraspeckles)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990448"(exon-exon junction complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034769|interpro:IPR034772|interpro:IPR035979|mint:Q16630|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:4B4N|rcsb pdb:4U0A|rcsb pdb:4U0B|rcsb pdb:4WYM|rcsb pdb:6AY9|rcsb pdb:6GX9|reactome:R-HSA-1839117|reactome:R-HSA-5655302|dip:DIP-34501N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:nvZBuI+X/m+5MGIsfh2ToVe5nFs9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:O00507 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-2322142|uniprotkb:O14601|intact:EBI-28977565|ensembl:ENSP00000342812|ensembl:ENSP00000498372 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:usp9y_human(display_long)|uniprotkb:USP9Y(gene name)|psi-mi:USP9Y(display_short)|uniprotkb:DFFRY(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-Y(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-Y(gene name synonym)|uniprotkb:Fat facets protein-related, Y-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, Y chromosome(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-Y(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_004645.2|ensembl:ENSP00000342812|ensembl:ENSP00000498372|ensembl:ENSG00000114374(gene)|ensembl:ENST00000338981(transcript)|ensembl:ENST00000651177(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0070410"(co-SMAD binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR038765|mint:O00507 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:hUnNhsQfcbxhAccrjno5b0wRSSA9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:O95232 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-395671|uniprotkb:Q6PHR9|uniprotkb:Q9NUY0|uniprotkb:Q9P2S7|uniprotkb:B3KN54|uniprotkb:D3DTY1|ensembl:ENSP00000240304|ensembl:ENSP00000425092 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:lc7l3_human(display_long)|uniprotkb:LUC7L3(gene name)|psi-mi:LUC7L3(display_short)|uniprotkb:cAMP regulatory element-associated protein 1(gene name synonym)|uniprotkb:Luc7A(gene name synonym)|uniprotkb:Okadaic acid-inducible phosphoprotein OA48-18(gene name synonym)|uniprotkb:CREAP1(gene name synonym)|uniprotkb:O48(gene name synonym)|uniprotkb:CROP(gene name synonym)|uniprotkb:Cisplatin resistance-associated-overexpressed protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_006098.2|refseq:NP_057508.2|ensembl:ENSG00000108848(gene)|ensembl:ENST00000240304(transcript)|ensembl:ENST00000505658(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:O95232 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:UywyrESxjWtcX7tXUEvhA6Dks709606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9UJX2 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-396137|uniprotkb:O75433|uniprotkb:Q9BS73|uniprotkb:B4E3A2|uniprotkb:B7WP05|uniprotkb:Q53FN2|uniprotkb:A8K6E5|uniprotkb:D3DQB7|ensembl:ENSP00000378350 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:cdc23_human(display_long)|uniprotkb:CDC23(gene name)|psi-mi:CDC23(display_short)|uniprotkb:ANAPC8(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 8(gene name synonym)|uniprotkb:Cyclosome subunit 8(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_004652.2|dip:DIP-32959N|ensembl:ENSG00000094880(gene)|ensembl:ENST00000394886(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR007192(Cdc23)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX2|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:uTZL2UHzZHLoKnio/1LcuSzZpW09606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9H074 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9NWU2 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1051077|uniprotkb:Q8N5M5|uniprotkb:E1P5I3|ensembl:ENSP00000266069 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:gid8_human(display_long)|uniprotkb:GID8(gene name)|psi-mi:GID8(display_short)|uniprotkb:C20orf11(gene name synonym)|uniprotkb:Two hybrid-associated protein 1 with RanBPM(gene name synonym)|uniprotkb:TWA1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_060366.1|ensembl:ENSG00000101193(gene)|ensembl:ENST00000266069(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR024964|mint:Q9NWU2|rcsb pdb:7NSC - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:P0HsK72KT6OPKKw7lVSJ/FiY4CU9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:O43809 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-355720|uniprotkb:Q6IB85|uniprotkb:Q6NE84|ensembl:ENSP00000300291 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:cpsf5_human(display_long)|uniprotkb:NUDT21(gene name)|psi-mi:NUDT21(display_short)|uniprotkb:CFIM25(gene name synonym)|uniprotkb:CPSF25(gene name synonym)|uniprotkb:CPSF5(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 25 kDa subunit(gene name synonym)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 21(gene name synonym)|uniprotkb:Cleavage factor Im complex 25 kDa subunit(gene name synonym)|uniprotkb:Nudix hydrolase 21(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_008937.1|ensembl:ENSG00000167005(gene)|ensembl:ENST00000300291(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006397"(mRNA processing)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0031439"(positive regulation of mRNA cleavage)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2000975"(positive regulation of pro-B cell differentiation)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR015797(NUDIX)|interpro:IPR016706(Cleavage and polyadenylation specificity factor, 25 kDa subunit)|mint:O43809|rcsb pdb:2CL3|rcsb pdb:2J8Q|rcsb pdb:3BAP|rcsb pdb:3BHO|rcsb pdb:3MDG|rcsb pdb:3MDI|rcsb pdb:3N9U|rcsb pdb:3P5T|rcsb pdb:3P6Y|rcsb pdb:3Q2S|rcsb pdb:3Q2T|rcsb pdb:5R4P|rcsb pdb:5R4Q|rcsb pdb:5R4R|rcsb pdb:5R4S|rcsb pdb:5R4T|rcsb pdb:5R4U|rcsb pdb:5R64|rcsb pdb:5R65|rcsb pdb:5R66|rcsb pdb:5R67|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|dip:DIP-42502N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:Acad4mYVuS+Eox+X2CH8PYUkGAA9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q6UN15 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1021914|uniprotkb:Q0VGE0|uniprotkb:Q499Y4|uniprotkb:Q49AU3|uniprotkb:Q7Z608|uniprotkb:Q8WVN3|uniprotkb:Q96F80|uniprotkb:Q9H077|intact:EBI-11535474|ensembl:ENSP00000336752|uniprotkb:B4DIR3|uniprotkb:G3XAD6 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:fip1_human(display_long)|uniprotkb:Factor interacting with PAP(gene name synonym)|uniprotkb:FIP1-like 1 protein(gene name synonym)|uniprotkb:Rearranged in hypereosinophilia(gene name synonym)|uniprotkb:FIP1L1(gene name)|psi-mi:FIP1L1(display_short)|uniprotkb:FIP1(gene name synonym)|uniprotkb:RHE(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENST00000306932|ensembl:ENSP00000302993|ensembl:ENSP00000336752|ensembl:ENST00000358575|ensembl:ENSP00000351383|ensembl:ENST00000507922|ensembl:ENSP00000425456|refseq:NP_001128409.1|refseq:NP_001128410.1|refseq:NP_112179.2|ensembl:ENSG00000145216(gene)|ensembl:ENST00000337488(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR007854(Fip1)|mint:Q6UN15|rcsb pdb:7K95|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|reactome:R-HSA-9673766|dip:DIP-42503N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:41uK1l8RV99q4k4Z7K9zeG3TJHA9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9NYF8 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-437804|ensembl:ENSP00000435210|uniprotkb:Q86WY0|uniprotkb:Q14673|uniprotkb:Q86WU6|uniprotkb:B7ZM58|uniprotkb:A2RU75|uniprotkb:E1P586 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:bclf1_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 1(gene name synonym)|uniprotkb:BCLAF1(gene name)|psi-mi:BCLAF1(display_short)|uniprotkb:BTF(gene name synonym)|uniprotkb:KIAA0164(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000029363(gene)|ensembl:ENST00000531224(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000144"(positive regulation of DNA-templated transcription, initiation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR026668|interpro:IPR029199|mint:Q9NYF8|refseq:NP_001070908.1|refseq:NP_001070909.1|refseq:NP_055554.1|refseq:NP_001287967.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:v6qbjyjKVCv0B/olkjQfTPKWqBw9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9UL63 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1048053|uniprotkb:A4D1M8|uniprotkb:A6NG43|uniprotkb:Q9NSK4|uniprotkb:Q9NUS8|ensembl:ENSP00000323527 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:mkln1_human(display_long)|uniprotkb:MKLN1(gene name)|psi-mi:MKLN1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001138826.1|refseq:NP_037387.2|ensembl:ENSG00000128585(gene)|ensembl:ENST00000352689(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|mint:Q9UL63|refseq:NP_001308245.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:7yT0576+rLpdpgT/cqXPEuf80/g9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:O75165 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-4324603|uniprotkb:Q6ZSW1|uniprotkb:Q6ZUT5|uniprotkb:Q3L0T1|uniprotkb:Q6PI82|uniprotkb:Q6UJ77|uniprotkb:Q86XG3|uniprotkb:Q96DC1|uniprotkb:Q9BWK9|ensembl:ENSP00000260818 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:djc13_human(display_long)|uniprotkb:DNAJC13(gene name)|psi-mi:DNAJC13(display_short)|uniprotkb:KIAA0678(gene name synonym)|uniprotkb:RME8(gene name synonym)|uniprotkb:Required for receptor-mediated endocytosis 8(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_056083.3|ensembl:ENSG00000138246(gene)|ensembl:ENST00000260818(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902954"(regulation of early endosome to recycling endosome transport)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025640|go:"GO:0001649"(osteoblast differentiation)|interpro:IPR035445|interpro:IPR036869|mint:O75165|reactome:R-HSA-6798695 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:pCRan1osG3cVCkd4ayZqE5othPI9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9Y5X1 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q86SQ7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1047850|uniprotkb:Q3ZCR6|uniprotkb:Q8N5F2|uniprotkb:Q9P0F1|uniprotkb:O60527|ensembl:ENSP00000355499|ensembl:ENSP00000483550 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:sdcg8_human(display_long)|uniprotkb:Antigen NY-CO-8(gene name synonym)|uniprotkb:Centrosomal colon cancer autoantigen protein(gene name synonym)|uniprotkb:SDCCAG8(gene name)|psi-mi:SDCCAG8(display_short)|uniprotkb:CCCAP(gene name synonym)|uniprotkb:NPHP10(gene name synonym)|uniprotkb:HSPC085(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_006633.1|ensembl:ENSG00000054282(gene)|ensembl:ENSG00000276111(gene)|ensembl:ENST00000366541(transcript)|ensembl:ENST00000622598(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0097733"(photoreceptor cell cilium)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR031887|mint:Q86SQ7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_005273080.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:Z3ynDtbmAV7usLzKH+M3Ilf6Ebw9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q96RF0 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-298169|uniprotkb:Q05BB3|uniprotkb:Q0VG02|ensembl:ENSP00000342276|uniprotkb:B4E2B3|uniprotkb:H7BXX3 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:snx18_human(display_long)|uniprotkb:SNX18(gene name)|psi-mi:SNX18(display_short)|uniprotkb:SH3 and PX domain-containing protein 3B(gene name synonym)|uniprotkb:SH3PXD3B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001096045.1|refseq:NP_001138899.1|refseq:NP_443102.2|ensembl:ENSG00000178996(gene)|go:"GO:0006897"(endocytosis)|ensembl:ENST00000343017(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028646|interpro:IPR035557|interpro:IPR035703|interpro:IPR036028|interpro:IPR036871|mint:Q96RF0|reactome:R-HSA-8856828 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:HpHLfTZ0EfhC6oMHeSr1GCgZaI49606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q96PY6 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-373615|uniprotkb:Q9Y594|ensembl:ENSP00000408020|uniprotkb:Q14CB7|uniprotkb:Q5H9T1|uniprotkb:Q6PIB8|uniprotkb:Q96SS2|uniprotkb:Q9H6P7|uniprotkb:Q05DG5|uniprotkb:G5E9Z3 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:nek1_human(display_long)|uniprotkb:NEK1(gene name)|psi-mi:NEK1(display_short)|uniprotkb:KIAA1901(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-55(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001186326.1|refseq:NP_001186327.1|refseq:NP_001186328.1|refseq:NP_001186329.1|refseq:NP_036356.1|ensembl:ENSG00000137601(gene)|ensembl:ENST00000439128(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0060271"(cilium assembly)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4APC|rcsb pdb:4B9D|refseq:XP_011530305.1|refseq:XP_011530306.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:/Zes5a/DuVLXGUozIBoCHv4qtm89606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:O43464 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-517086|uniprotkb:Q9HBZ4|uniprotkb:Q9P0Y3|uniprotkb:Q9P0Y4|ensembl:ENSP00000258080 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:htra2_human(display_long)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)|uniprotkb:Serine proteinase OMI(gene name synonym)|uniprotkb:Serine protease 25(gene name synonym)|uniprotkb:HTRA2(gene name)|psi-mi:HTRA2(display_short)|uniprotkb:PRSS25(gene name synonym)|uniprotkb:OMI(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_037379.1|refseq:NP_659540.1|refseq:NP_001308656.1|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904924"(negative regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1905370"(serine-type endopeptidase complex)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|interpro:IPR041489|mint:O43464|rcsb pdb:1LCY|rcsb pdb:2PZD|rcsb pdb:5FHT|rcsb pdb:5M3N|rcsb pdb:5M3O|rcsb pdb:5TNY|ensembl:ENSG00000115317(gene)|ensembl:ENST00000258080(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009635"(response to herbicide)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019742"(pentacyclic triterpenoid metabolic process)|go:"GO:0030900"(forebrain development)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048666"(neuron development)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071300"(cellular response to retinoic acid)|rcsb pdb:5TNZ|rcsb pdb:5TO0|rcsb pdb:5TO1|rcsb pdb:5WYN - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:IaLYfoH7H9K64U0KrEY7iB1vAfU9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9P2I0 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1043224|uniprotkb:Q6NSJ1|uniprotkb:Q9H3W7|ensembl:ENSP00000298875|uniprotkb:B3KME1 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:cpsf2_human(display_long)|uniprotkb:Cleavage and polyadenylation specificity factor 100 kDa subunit(gene name synonym)|uniprotkb:CPSF2(gene name)|psi-mi:CPSF2(display_short)|uniprotkb:CPSF100(gene name synonym)|uniprotkb:KIAA1367(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 interpro:IPR001279(Beta-lactamase-like)|interpro:IPR011108(RNA-metabolising metallo-beta-lactamase)|interpro:IPR022712|interpro:IPR025069|interpro:IPR027075|interpro:IPR035639|interpro:IPR036866|mint:Q9P2I0|rcsb pdb:6URG|rcsb pdb:6V4X|reactome:R-HSA-159231|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|ensembl:ENSG00000165934(gene)|ensembl:ENST00000298875(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0016020"(membrane)|refseq:NP_059133.1|refseq:NP_001309201.1|dip:DIP-42500N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:RYiaQ8q9VM7htGre4S8PkSQaCz89606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q8N5Z5 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-743960|uniprotkb:B0QYA9|uniprotkb:B0QYB0|uniprotkb:O95517|ensembl:ENSP00000385096 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:kcd17_human(display_long)|uniprotkb:KCTD17(gene name)|psi-mi:KCTD17(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001269613.1|refseq:NP_001269614.1|refseq:NP_001269615.1|refseq:NP_078957.2|ensembl:ENSG00000100379(gene)|ensembl:ENST00000403888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0030030"(cell projection organization)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8N5Z5|rcsb pdb:5A6R - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:998kw0bw9dTtZQYgdqYCNxIKG0w9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q7L5Y9 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-10984762|ensembl:ENSP00000302830|uniprotkb:O95285|uniprotkb:Q5JB54|uniprotkb:Q6ZRD6|uniprotkb:Q9NW84|uniprotkb:Q9H9Z4|uniprotkb:Q9BQ11|uniprotkb:Q9H9V6 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:maea_human(display_long)|uniprotkb:MAEA(gene name)|psi-mi:MAEA(display_short)|uniprotkb:Cell proliferation-inducing gene 5 protein(gene name synonym)|uniprotkb:EMP(gene name synonym)|uniprotkb:Erythroblast macrophage protein(gene name synonym)|uniprotkb:Human lung cancer oncogene 10 protein(gene name synonym)|uniprotkb:Macrophage erythroblast attacher(gene name synonym)|uniprotkb:P44EMLP(gene name synonym)|uniprotkb:HLC10(orf name)|uniprotkb:PIG5(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001017405.1|refseq:NP_001284360.1|refseq:NP_005873.2|ensembl:ENSG00000090316(gene)|ensembl:ENST00000303400(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0034657"(GID complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0048822"(enucleate erythrocyte development)|go:"GO:0051301"(cell division)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR024964|interpro:IPR027714|interpro:IPR044063|mint:Q7L5Y9 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:8eoZgqL1bgRlGgQ3YiJDejdFWtk9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9H7D7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1046864|uniprotkb:A0MNN3|uniprotkb:Q4G100|uniprotkb:Q59EC4|uniprotkb:Q5GLZ9|uniprotkb:Q86UY4|uniprotkb:Q9H3C2|ensembl:ENSP00000504428|intact:EBI-1642504 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:wdr26_human(display_long)|uniprotkb:CUL4- and DDB1-associated WDR protein 2(gene name synonym)|uniprotkb:Myocardial ischemic preconditioning up-regulated protein 2(gene name synonym)|uniprotkb:WDR26(gene name)|psi-mi:WDR26(display_short)|uniprotkb:CDW2(gene name synonym)|uniprotkb:MIP2(gene name synonym)|uniprotkb:PRO0852(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9H7D7|ensembl:ENSG00000162923(gene)|ensembl:ENST00000678917(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|refseq:NP_001108585.2|refseq:NP_079436.4 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:HRA6f68aldUqB1rVa7uM9srSyR49606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q8IVV7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-11918778|ensembl:ENSP00000268719|uniprotkb:Q8TEB5|uniprotkb:Q9BW50 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:gid4_human(display_long)|uniprotkb:GID4(gene name)|psi-mi:GID4(display_short)|uniprotkb:C17orf39(gene name synonym)|uniprotkb:VID24(gene name synonym)|uniprotkb:Vacuolar import and degradation protein 24 homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 ensembl:ENSG00000141034(gene)|ensembl:ENST00000268719(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR018618|rcsb pdb:6CCR|rcsb pdb:6CCT|rcsb pdb:6CCU|rcsb pdb:6CD8|rcsb pdb:6CD9|rcsb pdb:6CDC|rcsb pdb:6CDG|rcsb pdb:6WZX|rcsb pdb:6WZZ|rcsb pdb:7NSC|refseq:NP_076957.3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:oUmzM7r3QK/A65TG2go2mQMgADI9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q96S59 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q6VN20 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-310569|intact:EBI-1056526|uniprotkb:A4FTY2|uniprotkb:Q9P264|intact:EBI-10984753|ensembl:ENSP00000316589|uniprotkb:B4DID0|uniprotkb:B4DQH9|uniprotkb:E7EW27 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:rbp10_human(display_long)|uniprotkb:RANBP10(gene name)|psi-mi:RANBP10(display_short)|uniprotkb:KIAA1464(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_065901.1|refseq:NP_001307167.1|refseq:NP_001307168.1|refseq:NP_001307169.1|ensembl:ENSG00000141084(gene)|ensembl:ENST00000317506(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q6VN20|reactome:R-HSA-8851805 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:DaNPLQf0T/+lsKrL+uhGtWXG0pI9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q8IUR7 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:P62699 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-11721624|uniprotkb:D6W568|uniprotkb:Q65Z97|uniprotkb:Q8R174|uniprotkb:Q9D6M1|uniprotkb:Q9UMX7|uniprotkb:Q9Y3C9|ensembl:ENSP00000261353|ensembl:ENSP00000368834|ensembl:ENSP00000368835|ensembl:ENSP00000383974|ensembl:ENSP00000385278 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:ypel5_human(display_long)|uniprotkb:YPEL5(gene name)|psi-mi:YPEL5(display_short)|uniprotkb:CGI-127(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_001120871.1|refseq:NP_001120872.1|refseq:NP_001120873.1|refseq:NP_057145.1|ensembl:ENSG00000119801(gene)|ensembl:ENST00000261353(transcript)|ensembl:ENST00000379519(transcript)|ensembl:ENST00000379520(transcript)|ensembl:ENST00000402003(transcript)|ensembl:ENST00000402708(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030496"(midbody)|go:"GO:0046872"(metal ion binding)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR004910(Yippee-like protein)|interpro:IPR034751|interpro:IPR039058|mint:P62699|reactome:R-HSA-6798695|refseq:XP_016859807.1|refseq:XP_016859808.1|refseq:XP_016859809.1|refseq:XP_016859810.1|refseq:XP_016859811.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:ZpDZwTkWSDPONRLnApZ8fKl/NHk9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9C0H6 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-9478822|uniprotkb:B2RTW2|uniprotkb:Q9Y3J5|ensembl:ENSP00000362211|ensembl:ENSP00000498718 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:klhl4_human(display_long)|uniprotkb:KLHL4(gene name)|psi-mi:KLHL4(display_short)|uniprotkb:KIAA1687(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_061990.2|refseq:NP_476503.1|ensembl:ENSG00000102271(gene)|ensembl:ENST00000373119(transcript)|ensembl:ENST00000652270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:mSqhmsHz+jhh8ZMQoIWJeSm/ILk9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98143 uniprotkb:Q9H871 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 intact:EBI-2797992|uniprotkb:Q6NTF0|uniprotkb:Q9H9H2|uniprotkb:Q9H6W5|uniprotkb:D6W5M6|ensembl:ENSP00000283632 psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:rmd5a_human(display_long)|uniprotkb:RMND5A(gene name)|psi-mi:RMND5A(display_short)|uniprotkb:P44CTLH(gene name synonym)|uniprotkb:Protein RMD5 homolog A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062843|imex:IM-26114-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 refseq:NP_073617.1|ensembl:ENSG00000153561(gene)|ensembl:ENST00000283632(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0034657"(GID complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR024964|interpro:IPR037680|interpro:IPR044063|mint:Q9H871 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/10/21 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rogid:+wLGFpC1YJ1y6PVi15799YxByKI9606 rigid:RhIwG8dyI6/k/bTajDolQNvDw7c false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76TK5 uniprotkb:P36873 intact:EBI-14033469|uniprotkb:Q2HRA9 intact:EBI-356283|ensembl:ENSP00000335084 psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:pp1g_human(display_long)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062885|imex:IM-26114-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0004721"(phosphoprotein phosphatase activity)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000335007(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0043197"(dendritic spine)|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|mint:P36873|rcsb pdb:1IT6|rcsb pdb:1JK7|rcsb pdb:1U32|rcsb pdb:2BCD|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|rcsb pdb:2BDX|rcsb pdb:4UT2|rcsb pdb:4UT3|go:"GO:0046872"(metal ion binding)|rcsb pdb:5INB|go:"GO:0047485"(protein N-terminus binding)|rcsb pdb:5J28|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|reactome:R-HSA-141444|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-9648025|reactome:R-HSA-9660537|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-400253|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-68877|refseq:NP_001231903.1|refseq:NP_002701.1|dip:DIP-749N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rogid:SyjV/4d9V8lV/BXub2KESPKvupA9606 rigid:urLv/UVnSFb7881+yv0shmevHnE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76TK5 uniprotkb:Q15435 intact:EBI-14033469|uniprotkb:Q2HRA9 intact:EBI-1024281|uniprotkb:Q9UQE5|uniprotkb:Q9UQE6|uniprotkb:Q9Y6K4|ensembl:ENSP00000234038|uniprotkb:B4DFD4|ensembl:ENSP00000385657|uniprotkb:B5MCY6 psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:pp1r7_human(display_long)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:SDS22(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062885|imex:IM-26114-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) ensembl:ENSG00000115685(gene)|refseq:NP_002703.1|ensembl:ENST00000234038(transcript)|ensembl:ENST00000407025(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|rcsb pdb:6HKW|rcsb pdb:6MKY|rcsb pdb:6OBN|rcsb pdb:6OBP|refseq:NP_001269338.1|refseq:NP_001269339.1|refseq:NP_001269340.1|refseq:NP_001269341.1|refseq:NP_001269342.1|refseq:NP_001269343.1|dip:DIP-1005N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rogid:HKHhTMtEgPpOdf/lS59bZAOrDjk9606 rigid:urLv/UVnSFb7881+yv0shmevHnE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76TK5 uniprotkb:P62140 intact:EBI-14033469|uniprotkb:Q2HRA9 intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769 psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062885|imex:IM-26114-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606 rigid:urLv/UVnSFb7881+yv0shmevHnE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76TK5 uniprotkb:P62136 intact:EBI-14033469|uniprotkb:Q2HRA9 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062885|imex:IM-26114-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 rigid:urLv/UVnSFb7881+yv0shmevHnE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P62875 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-359527|ensembl:ENSP00000324124|ensembl:ENSP00000432807|uniprotkb:P52436|uniprotkb:Q6FHX3 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpab5_human(display_long)|uniprotkb:POLR2L(gene name)|psi-mi:POLR2L(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit L(gene name synonym)|uniprotkb:RPB10 homolog(gene name synonym)|uniprotkb:RNA polymerase II 7.6 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) ensembl:ENSG00000177700(gene)|ensembl:ENST00000322028(transcript)|ensembl:ENST00000534030(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042797"(tRNA transcription by RNA polymerase III)|interpro:IPR000268(RNA polymerases, N/8 Kd subunits)|interpro:IPR020789|interpro:IPR023580|mint:P62875|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|refseq:NP_066951.1|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-75955|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-203927|dip:DIP-32960N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:uDzgKgHzFTPxFaV1GeUYdYMa4Gk9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P52434 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-359505|uniprotkb:P53802|uniprotkb:Q969R0|ensembl:ENSP00000392913|uniprotkb:C9J413|uniprotkb:C9JBJ6|uniprotkb:C9JCU7|uniprotkb:C9JUA8 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpab3_human(display_long)|uniprotkb:POLR2H(gene name)|psi-mi:POLR2H(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit H(gene name synonym)|uniprotkb:DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide(gene name synonym)|uniprotkb:RPB17(gene name synonym)|uniprotkb:RPB8 homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) ensembl:ENSG00000163882(gene)|ensembl:ENST00000456318(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR005570(RNA polymerase, Rpb8)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P52434|rcsb pdb:2F3I|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|refseq:NP_006223.2|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|rcsb pdb:7AE3|reactome:R-HSA-1834949|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-427413|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-203927|refseq:NP_001265627.1|refseq:NP_001265628.1|refseq:NP_001265629.1|refseq:NP_001265644.1|refseq:NP_001265643.1|refseq:XP_006713729.1|refseq:XP_006713730.1|refseq:XP_016862125.1|refseq:XP_016862126.1|dip:DIP-27556N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:h7BRWDi8wRbnw/FcFo25bnlVNkE9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:O94763 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:Q9H6T3 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P19387 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-394729|uniprotkb:O15161|ensembl:ENSP00000219252 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb3_human(display_long)|uniprotkb:POLR2C(gene name)|psi-mi:POLR2C(display_short)|uniprotkb:A-152E5.7(orf name)|uniprotkb:DNA-directed RNA polymerase II subunit C(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 33 kDa polypeptide(gene name synonym)|uniprotkb:RPB31(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_116558.1|ensembl:ENSG00000102978(gene)|ensembl:ENST00000219252(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR036603|interpro:IPR036643|mint:P19387|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32911N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:UXFC+i+QqB2WRgL9OiYSQ66L36c9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P24928 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P52435 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-394753|uniprotkb:O43375|uniprotkb:A5D6V8|ensembl:ENSP00000292614 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb11_human(display_long)|uniprotkb:POLR2J(gene name)|psi-mi:POLR2J(display_short)|uniprotkb:POLR2J1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit J-1(gene name synonym)|uniprotkb:RNA polymerase II 13.3 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_006225.1|ensembl:ENSG00000005075(gene)|ensembl:ENST00000292614(transcript)|go:"GO:0001055"(RNA polymerase II activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0030275"(LRR domain binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR008193(DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site)|interpro:IPR009025(DNA-directed RNA polymerase, RBP11-like)|interpro:IPR036603|interpro:IPR037685|mint:P52435|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32913N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:jK/DlwFrHHuEJ0Ns3wRoB3icmsA9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:Q9UHW5 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-395491|uniprotkb:Q53FS3|uniprotkb:Q6UVZ6|uniprotkb:Q7Z3D3|uniprotkb:Q8NEI2|uniprotkb:Q96HK9|uniprotkb:B2RC54|uniprotkb:D4YWV1|ensembl:ENSP00000228827|uniprotkb:F5H759 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:gpn3_human(display_long)|uniprotkb:ATPBD1C(gene name synonym)|uniprotkb:ATP-binding domain 1 family member C(gene name synonym)|uniprotkb:GPN3(gene name)|psi-mi:GPN3(display_short)|uniprotkb:AD-009(orf name)|uniprotkb:UNQ1876/PRO4319(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_001157844.1|refseq:NP_001157845.1|refseq:NP_057385.3|ensembl:ENSG00000111231(gene)|ensembl:ENST00000228827(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030228|mint:Q9UHW5 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:fKBsnLcvitaM76zQUW+MQXDPxTA9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:O94762 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-395321|ensembl:ENSP00000317636|uniprotkb:Q9P1W7|uniprotkb:Q9UNC8|uniprotkb:Q9H0B1|uniprotkb:Q6P4G0 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:recq5_human(display_long)|uniprotkb:RECQ5(gene name synonym)|uniprotkb:RECQL5(gene name)|psi-mi:RECQL5(display_short)|uniprotkb:RecQ protein-like 5(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) ensembl:ENSG00000108469(gene)|ensembl:ENST00000317905(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0051301"(cell division)|go:"GO:0051304"(chromosome separation)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010716(RecQ helicase-like 5)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032284|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_001003715.1|refseq:NP_001003716.1|refseq:NP_004250.4|mint:O94762|rcsb pdb:4BK0|rcsb pdb:5LB3|rcsb pdb:5LB5|rcsb pdb:5LB8|rcsb pdb:5LBA|refseq:XP_016880832.1|refseq:XP_016880833.1|dip:DIP-32964N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:lOMr1rIrRi78aQO2pQod/1V3Ku49606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P0CAP2 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-9657655|uniprotkb:Q96NF5|uniprotkb:Q6EFN8|uniprotkb:Q6EEV3|uniprotkb:Q9Y3V6|uniprotkb:Q8NC58|uniprotkb:Q96DI5|uniprotkb:Q6EF02|uniprotkb:Q6K050|uniprotkb:Q6K046|uniprotkb:Q6K051|uniprotkb:Q6EF01|uniprotkb:Q6EES2|uniprotkb:Q8NCF3|uniprotkb:Q6EM48|uniprotkb:Q6EF46|uniprotkb:Q6ZQZ3|uniprotkb:Q6EER8|uniprotkb:Q96JB7|uniprotkb:Q6EF00|ensembl:ENSP00000299638 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:grl1a_human(display_long)|uniprotkb:POLR2M(gene name)|psi-mi:POLR2M(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit M(gene name synonym)|uniprotkb:GRINL1A(gene name synonym)|uniprotkb:Glutamate receptor-like protein 1A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_001018112.1|refseq:NP_056347.1|dip:DIP-61933N|ensembl:ENSG00000255529(gene)|ensembl:ENST00000299638(transcript)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051685"(maintenance of ER location)|interpro:IPR026213|mint:P0CAP2|rcsb pdb:6DRD - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:G0QVxeD0uvJTl0VPn+b3pV6zLe89606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P53803 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-395357|uniprotkb:Q6IBD4|ensembl:ENSP00000342889 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpab4_human(display_long)|uniprotkb:POLR2K(gene name)|psi-mi:POLR2K(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit K(gene name synonym)|uniprotkb:RPB10alpha(gene name synonym)|uniprotkb:RNA polymerase II 7.0 kDa subunit(gene name synonym)|uniprotkb:ABC10-alpha(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_005025.1|ensembl:ENSG00000147669(gene)|ensembl:ENST00000353107(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006356"(regulation of transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0008270"(zinc ion binding)|interpro:IPR006591(RNA polymerase Rbp10)|interpro:IPR029040|interpro:IPR039747|mint:P53803|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-72086|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32968N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:dVF/14F1klTHtGh1gfpkGB3YMoU9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:Q8IXW5 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-395878|uniprotkb:Q49AS7|uniprotkb:Q9H8Y2|ensembl:ENSP00000476948|uniprotkb:C9JKB5 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpap2_human(display_long)|uniprotkb:RPAP2(gene name)|psi-mi:RPAP2(display_short)|uniprotkb:C1orf82(gene name synonym)|uniprotkb:RNA polymerase II-associated protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_079089.2|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0009301"(snRNA transcription)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0043175"(RNA polymerase core enzyme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070940"(dephosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR007308(Protein of unknown function DUF408)|interpro:IPR038534|interpro:IPR039693|mint:Q8IXW5|rcsb pdb:7B7U|reactome:R-HSA-6807505|ensembl:ENSG00000122484(gene)|ensembl:ENST00000610020(transcript)|go:"GO:0005634"(nucleus)|dip:DIP-32939N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:niEFEvqkASycxkzfe9TYJuerUuY9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:O15514 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-394737|uniprotkb:Q52LT4|ensembl:ENSP00000272645 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb4_human(display_long)|uniprotkb:POLR2D(gene name)|psi-mi:POLR2D(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit D(gene name synonym)|uniprotkb:RNA polymerase II 16 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_004796.1|ensembl:ENSG00000144231(gene)|ensembl:ENST00000272645(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016607"(nuclear speck)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0045948"(positive regulation of translational initiation)|interpro:IPR005574(RNA polymerase II, Rpb4)|interpro:IPR006590(RNA polymerase II, Rpb4, core)|interpro:IPR010997(HRDC-like)|interpro:IPR038324|mint:O15514|rcsb pdb:2C35|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32912N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:qOGCRZ4FNc6fSBgoKUgbbCSHm889606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P62487 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-347928|ensembl:ENSP00000301788|uniprotkb:P52433|uniprotkb:Q2M1Z4|uniprotkb:B2R5C0 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb7_human(display_long)|uniprotkb:POLR2G(gene name)|psi-mi:POLR2G(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym)|uniprotkb:RPB7(gene name synonym)|uniprotkb:RNA polymerase II 19 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) ensembl:ENSG00000168002(gene)|ensembl:ENST00000301788(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|mint:P62487|rcsb pdb:2C35|rcsb pdb:5IYA|rcsb pdb:5IY6|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|rcsb pdb:5IY7|reactome:R-HSA-167200|reactome:R-HSA-167238|rcsb pdb:5IY8|rcsb pdb:5IY9|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-5601884|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|refseq:NP_002687.1|dip:DIP-32663N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:MtnIweuhSqLFov0c40uOiwv8Eas9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98140 uniprotkb:P36954 intact:EBI-14033488|uniprotkb:Q2HRA8 intact:EBI-395202|uniprotkb:Q6NW05|uniprotkb:B2R5J2|ensembl:ENSP00000221859 psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:rpb9_human(display_long)|uniprotkb:POLR2I(gene name)|psi-mi:POLR2I(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit I(gene name synonym)|uniprotkb:RNA polymerase II 14.5 kDa subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062894|imex:IM-26114-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) refseq:NP_006224.1|ensembl:ENSG00000105258(gene)|ensembl:ENST00000221859(transcript)|go:"GO:0001193"(maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR001529(DNA-directed RNA polymerase, M/15 kDa subunit)|interpro:IPR012164(DNA-directed RNA polymerase, subunit C11/M/9)|interpro:IPR019761|interpro:IPR034012|mint:P36954|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32917N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rogid:YZUW2UDzj1RhCC46iaX1LvYayNA9606 rigid:efBBpTpJVcef+JA1rEkRU4u3FCU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96EP0 uniprotkb:D0UZN7 intact:EBI-948111|uniprotkb:Q9H5F1|uniprotkb:Q9NWD2|uniprotkb:Q86VI2|uniprotkb:Q8TEI0|uniprotkb:Q96GB4|uniprotkb:Q96NF1|ensembl:ENSP00000315112|ensembl:ENSP00000496609|uniprotkb:A0A962 intact:EBI-2649308 psi-mi:rnf31_human(display_long)|uniprotkb:Zinc in-between-RING-finger ubiquitin-associated domain protein(gene name synonym)|uniprotkb:RNF31(gene name)|psi-mi:RNF31(display_short)|uniprotkb:ZIBRA(gene name synonym)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym) psi-mi:d0uzn7_hhv8(display_long)|uniprotkb:ORF25(gene name)|psi-mi:ORF25(display_short)|uniprotkb:HHV8GK18_gp29(orf name)|uniprotkb:MCP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062914|imex:IM-26114-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000092098(gene)|ensembl:ENSG00000285152(gene)|ensembl:ENST00000324103(transcript)|ensembl:ENST00000647495(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|refseq:NP_060469.4|refseq:NP_001297261.1|ensembl:ENSP00000315112|ensembl:ENST00000559275|ensembl:ENSP00000453574|ensembl:ENST00000642631|ensembl:ENSP00000494011|ensembl:ENSP00000496609|dip:DIP-44034N|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066|mint:Q96EP0|rcsb pdb:2CT7|rcsb pdb:4DBG|rcsb pdb:4JUY|rcsb pdb:4LJO|rcsb pdb:4LJP|rcsb pdb:4LJQ|rcsb pdb:4OWF|rcsb pdb:4OYJ|rcsb pdb:4OYK|rcsb pdb:4P09|rcsb pdb:4P0A|rcsb pdb:4P0B|rcsb pdb:5EDV|rcsb pdb:5X0W|rcsb pdb:6GZY|rcsb pdb:6KC5|rcsb pdb:6KC6|rcsb pdb:6SC5|rcsb pdb:6SC6|rcsb pdb:6SC7|rcsb pdb:6SC8|rcsb pdb:6SC9|reactome:R-HSA-5357905|reactome:R-HSA-5357956|rcsb pdb:5LJN interpro:IPR000912("Herpesvirus major capsid protein (MCP)")|interpro:IPR023233|go:"GO:0005198"(structural molecule activity)|go:"GO:0039622"(T=16 icosahedral viral capsid)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:6B43 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:5QylozByg2G8/5LnkorkdY5fPec9606 rogid:jgzai4vwo1tz2spQKEtZGcUBtes37296 rigid:Q8lJIMhAtvfNcNMZuZ1cB4wUZA0 false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:C7E5A9 uniprotkb:P05026 intact:EBI-14062922 intact:EBI-714630|ensembl:ENSP00000356789|ensembl:ENSP00000356790|uniprotkb:Q5TGZ3 psi-mi:c7e5a9_hhv8(display_long)|uniprotkb:ORF26(gene name)|psi-mi:ORF26(display_short)|uniprotkb:TRX2(gene name synonym)|uniprotkb:HHV8GK18_gp30(orf name) psi-mi:at1b1_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:ATP1B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062920|imex:IM-26114-109 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002690(Herpesvirus VP23-like capsid protein)|rcsb pdb:6B43|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019069"(viral capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:6PPD|rcsb pdb:6PPH ensembl:ENSG00000143153(gene)|ensembl:ENST00000367815(transcript)|ensembl:ENST00000367816(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030315"(T-tubule)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|mint:P05026|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0098655"(cation transmembrane transport)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044861"(protein transport into plasma membrane raft)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046982"(protein heterodimerization activity)|refseq:NP_001668.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:48Xk4JZx6/i1aWOWxzi+Fg5ZfqQ37296 rogid:kE/mTDRgwTdf/AWUD0ZFpPN4FkE9606 rigid:9+4v79RS8FFzSq5lNqoXrzxqPks false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:C7E5A9 uniprotkb:Q7KZN9 intact:EBI-14062922 intact:EBI-3248549|ensembl:ENSP00000016171|uniprotkb:Q7Z3Q3|uniprotkb:O75878|uniprotkb:Q5TD00|uniprotkb:O60556|uniprotkb:A8K6I9|uniprotkb:Q5TD01|uniprotkb:Q9NTN0 psi-mi:c7e5a9_hhv8(display_long)|uniprotkb:ORF26(gene name)|psi-mi:ORF26(display_short)|uniprotkb:TRX2(gene name synonym)|uniprotkb:HHV8GK18_gp30(orf name) psi-mi:cox15_human(display_long)|uniprotkb:COX15(gene name)|psi-mi:COX15(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062920|imex:IM-26114-109 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002690(Herpesvirus VP23-like capsid protein)|rcsb pdb:6B43|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019069"(viral capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:6PPD|rcsb pdb:6PPH ensembl:ENSG00000014919(gene)|ensembl:ENST00000016171(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0006784"(heme A biosynthetic process)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008535"(respiratory chain complex IV assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016627"(oxidoreductase activity, acting on the CH-CH group of donors)|go:"GO:0016653"("oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor")|go:"GO:0020037"(heme binding)|go:"GO:0045333"(cellular respiration)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070069"(cytochrome complex)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR003780(Cytochrome oxidase assembly)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR023754|reactome:R-HSA-189451|refseq:NP_004367.2|refseq:NP_510870.1|refseq:NP_001307903.1|refseq:NP_001307904.1|refseq:NP_001307905.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:48Xk4JZx6/i1aWOWxzi+Fg5ZfqQ37296 rogid:wdz9gN+Wa6J/2OWm1flGDTmR7vM9606 rigid:9+4v79RS8FFzSq5lNqoXrzxqPks false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:C7E5A9 uniprotkb:P51553 intact:EBI-14062922 intact:EBI-1210876|uniprotkb:Q9BUU5|uniprotkb:E9PDD5|ensembl:ENSP00000217901 psi-mi:c7e5a9_hhv8(display_long)|uniprotkb:ORF26(gene name)|psi-mi:ORF26(display_short)|uniprotkb:TRX2(gene name synonym)|uniprotkb:HHV8GK18_gp30(orf name) psi-mi:idh3g_human(display_long)|uniprotkb:IDH3G(gene name)|psi-mi:IDH3G(display_short)|uniprotkb:Isocitric dehydrogenase subunit gamma(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit gamma"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14062920|imex:IM-26114-109 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002690(Herpesvirus VP23-like capsid protein)|rcsb pdb:6B43|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019069"(viral capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:6PPD|rcsb pdb:6PPH refseq:NP_004126.1|refseq:NP_777358.1|ensembl:ENSG00000067829(gene)|ensembl:ENST00000217901(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|interpro:IPR024084|mint:P51553|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-1268020|reactome:R-HSA-71403 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/17 rogid:48Xk4JZx6/i1aWOWxzi+Fg5ZfqQ37296 rogid:CQ3xfzDzQreBvU2mRPSg5xUfjKY9606 rigid:9+4v79RS8FFzSq5lNqoXrzxqPks false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98138 uniprotkb:P49257 intact:EBI-2608669|uniprotkb:Q2HRA5 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:q98138_hhv8(display_long)|uniprotkb:ORF27(gene name)|psi-mi:ORF27(display_short)|uniprotkb:HHV8GK18_gp31(orf name) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063269|imex:IM-26114-131 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129380.1 refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:q6IHPi3wat9Y08JQXqCiEJy6JpQ37296 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 rigid:MAG52CwWQwgeXDkM4M3NvIcJnTQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98138 uniprotkb:O15228 intact:EBI-2608669|uniprotkb:Q2HRA5 intact:EBI-726776|uniprotkb:Q5TBH7|uniprotkb:Q9BWC2|uniprotkb:B4DNM9|ensembl:ENSP00000355607 psi-mi:q98138_hhv8(display_long)|uniprotkb:ORF27(gene name)|psi-mi:ORF27(display_short)|uniprotkb:HHV8GK18_gp31(orf name) psi-mi:gnpat_human(display_long)|uniprotkb:Glycerone-phosphate O-acyltransferase(gene name synonym)|uniprotkb:"Acyl-CoA:dihydroxyacetonephosphateacyltransferase"(gene name synonym)|uniprotkb:GNPAT(gene name)|psi-mi:GNPAT(display_short)|uniprotkb:DAPAT(gene name synonym)|uniprotkb:DHAPAT(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063269|imex:IM-26114-131 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129380.1 refseq:NP_055051.1|refseq:NP_001303279.1|ensembl:ENSG00000116906(gene)|ensembl:ENST00000366647(transcript)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007584"(response to nutrient)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016287"(glycerone-phosphate O-acyltransferase activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0061024"(membrane organization)|go:"GO:0070542"(response to fatty acid)|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|interpro:IPR022284|interpro:IPR028353|interpro:IPR041728|reactome:R-HSA-1483166|reactome:R-HSA-75896|reactome:R-HSA-9033241 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:q6IHPi3wat9Y08JQXqCiEJy6JpQ37296 rogid:guKwW4vdqhvUhZOFcX40s+LLk3k9606 rigid:MAG52CwWQwgeXDkM4M3NvIcJnTQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98138 uniprotkb:Q92791 intact:EBI-2608669|uniprotkb:Q2HRA5 intact:EBI-13943414|ensembl:ENSP00000347649|ensembl:ENSP00000377505|uniprotkb:Q53GI6|uniprotkb:Q9H4F6 psi-mi:q98138_hhv8(display_long)|uniprotkb:ORF27(gene name)|psi-mi:ORF27(display_short)|uniprotkb:HHV8GK18_gp31(orf name) psi-mi:sc65_human(display_long)|uniprotkb:P3H4(gene name)|psi-mi:P3H4(display_short)|uniprotkb:LEPREL4(gene name synonym)|uniprotkb:Leprecan-like protein 4(gene name synonym)|uniprotkb:NOL55(gene name synonym)|uniprotkb:Nucleolar autoantigen No55(gene name synonym)|uniprotkb:Prolyl 3-hydroxylase family member 4(gene name synonym)|uniprotkb:SC65(gene name synonym)|uniprotkb:Synaptonemal complex protein SC65(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063269|imex:IM-26114-131 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129380.1 ensembl:ENSG00000141696(gene)|ensembl:ENST00000355468(transcript)|ensembl:ENST00000393928(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046849"(bone remodeling)|go:"GO:1902494"(catalytic complex)|interpro:IPR033213|refseq:NP_006446.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:q6IHPi3wat9Y08JQXqCiEJy6JpQ37296 rogid:i20O7LYwB0++JeRbgMw/v8Af/gM9606 rigid:MAG52CwWQwgeXDkM4M3NvIcJnTQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98138 uniprotkb:Q15155 intact:EBI-2608669|uniprotkb:Q2HRA5 intact:EBI-373107|uniprotkb:P78421|uniprotkb:Q8IW21|uniprotkb:Q96DG0|ensembl:ENSP00000287667|ensembl:ENSP00000482008 psi-mi:q98138_hhv8(display_long)|uniprotkb:ORF27(gene name)|psi-mi:ORF27(display_short)|uniprotkb:HHV8GK18_gp31(orf name) psi-mi:nomo1_human(display_long)|uniprotkb:PM5(gene name synonym)|uniprotkb:NOMO1(gene name)|psi-mi:NOMO1(display_short)|uniprotkb:pM5 protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063269|imex:IM-26114-131 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129380.1 refseq:NP_055102.3|interpro:IPR013783(Immunoglobulin-like fold)|ensembl:ENSG00000103512(gene)|ensembl:ENSG00000274779(gene)|ensembl:ENST00000287667(transcript)|ensembl:ENST00000619292(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043022"(ribosome binding)|interpro:IPR008969(Carboxypeptidase-like, regulatory region)|interpro:IPR013784(Carbohydrate-binding-like fold)|interpro:IPR041033|mint:Q15155 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:q6IHPi3wat9Y08JQXqCiEJy6JpQ37296 rogid:Dvi85VHhwmSC8qfJp1ufqUqPLdE9606 rigid:MAG52CwWQwgeXDkM4M3NvIcJnTQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98138 uniprotkb:Q96AY3 intact:EBI-2608669|uniprotkb:Q2HRA5 intact:EBI-2372475|uniprotkb:Q7Z3R4|uniprotkb:Q9H3N3|uniprotkb:Q9H6N5|uniprotkb:Q9UF89|uniprotkb:Q9H6J3|ensembl:ENSP00000317232 psi-mi:q98138_hhv8(display_long)|uniprotkb:ORF27(gene name)|psi-mi:ORF27(display_short)|uniprotkb:HHV8GK18_gp31(orf name) psi-mi:fkb10_human(display_long)|uniprotkb:FKBP10(gene name)|psi-mi:FKBP10(display_short)|uniprotkb:FKBP65(gene name synonym)|uniprotkb:FK506-binding protein 10(gene name synonym)|uniprotkb:Immunophilin FKBP65(gene name synonym)|uniprotkb:65 kDa FK506-binding protein(gene name synonym)|uniprotkb:PSEC0056(orf name)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063269|imex:IM-26114-131 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129380.1 refseq:NP_068758.3|ensembl:ENSG00000141756(gene)|ensembl:ENST00000321562(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0018208"(peptidyl-proline modification)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0085029"(extracellular matrix assembly)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q96AY3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:q6IHPi3wat9Y08JQXqCiEJy6JpQ37296 rogid:+oJpWT3zBh/fq0DqKPapFoVt3u09606 rigid:MAG52CwWQwgeXDkM4M3NvIcJnTQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:P40855 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:Q9Y3E0 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-4402607|uniprotkb:B2R4R4|uniprotkb:Q54A40|uniprotkb:Q6I9W6|uniprotkb:Q9P1R9|ensembl:ENSP00000229314 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:got1b_human(display_long)|uniprotkb:GOLT1B(gene name)|psi-mi:GOLT1B(display_short)|uniprotkb:GOT1A(gene name synonym)|uniprotkb:Golgi transport 1 homolog B(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 470(gene name synonym)|uniprotkb:hGOT1a(gene name synonym)|uniprotkb:CGI-141(orf name)|uniprotkb:HDCMA39P(orf name)|uniprotkb:UNQ432/PRO793(orf name)|uniprotkb:GCT2(gene name synonym)|uniprotkb:Germ cell tumor 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_057156.1|ensembl:ENSG00000111711(gene)|ensembl:ENST00000229314(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR007305(Got1-like protein)|mint:Q9Y3E0 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:dvlUtRzzjPZ9BTUtxhy2Sb3KB4Q9606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:Q9UET6 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-1055987|uniprotkb:O75670|uniprotkb:B2RCJ0|ensembl:ENSP00000326948 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:trm7_human(display_long)|uniprotkb:FTSJ1(gene name)|psi-mi:FTSJ1(display_short)|uniprotkb:JM23(orf name)|uniprotkb:Protein ftsJ homolog 1(gene name synonym)|uniprotkb:2'-O-ribose RNA methyltransferase TRM7 homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_036412.1|refseq:NP_803188.1|refseq:NP_001269086.1|refseq:XP_005272652.1|ensembl:ENST00000348411(transcript)|go:"GO:0001510"(RNA methylation)|go:"GO:0002128"(tRNA nucleoside ribose methylation)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0009020"("tRNA (guanosine-2'-O-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0052666"("tRNA (cytosine-2'-O-)-methyltransferase activity")|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR028590|interpro:IPR029063|mint:Q9UET6|reactome:R-HSA-6782315|ensembl:ENSG00000068438(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:N4L9nsU0Wj3FMVjYALdxpx56aZs9606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:P53701 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-10763431|uniprotkb:B3KUS1|uniprotkb:Q502X8|ensembl:ENSP00000326579|ensembl:ENSP00000370139|ensembl:ENSP00000370140 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:cchl_human(display_long)|uniprotkb:Cytochrome c-type heme lyase(gene name synonym)|uniprotkb:HCCS(gene name)|psi-mi:HCCS(display_short)|uniprotkb:CCHL(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_001116080.1|refseq:NP_001165462.1|refseq:NP_005324.3|ensembl:ENSG00000004961(gene)|ensembl:ENST00000321143(transcript)|ensembl:ENST00000380762(transcript)|ensembl:ENST00000380763(transcript)|go:"GO:0004408"(holocytochrome-c synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0018063"(cytochrome c-heme linkage)|go:"GO:0020037"(heme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000511(Cytochrome c and c1 haem-lyase)|mint:P53701 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:bJhUeXcA+kpWK7qF33e5hBwQops9606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:Q8N8J7 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-14063291|uniprotkb:Q49A91|uniprotkb:Q4W5C7|uniprotkb:Q8TBF9|ensembl:ENSP00000310182 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:f241a_human(display_long)|uniprotkb:FAM241A(gene name)|psi-mi:FAM241A(display_short)|uniprotkb:C4orf32(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_689613.1|ensembl:ENSG00000174749(gene)|ensembl:ENST00000309733(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR027953 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:B1vIlMTJcfrcGc8zEpNpyRI4pus9606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RI2 uniprotkb:Q96JB5 intact:EBI-14063281|uniprotkb:Q2HRA4 intact:EBI-718818|uniprotkb:Q53FA2|uniprotkb:Q9H3F8|uniprotkb:Q9H8G0|uniprotkb:Q9HBR9|uniprotkb:D3DTU1|uniprotkb:D3DTU2|uniprotkb:B7Z6N4|uniprotkb:F5H3I5|ensembl:ENSP00000344683 psi-mi:q76ri2_hhv8(display_long)|uniprotkb:ORF28(gene name)|psi-mi:ORF28(display_short)|uniprotkb:HHV8GK18_gp32(orf name) psi-mi:ck5p3_human(display_long)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym)|uniprotkb:Protein HSF-27(gene name synonym)|uniprotkb:CDK5RAP3(gene name)|psi-mi:CDK5RAP3(display_short)|uniprotkb:IC53(gene name synonym)|uniprotkb:MSTP016(orf name)|uniprotkb:OK/SW-cl.114(orf name)|uniprotkb:PP1553(orf name)|uniprotkb:LXXLL/leucine-zipper-containing ARF-binding protein(gene name synonym)|uniprotkb:LZAP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063279|imex:IM-26114-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129381.1|go:"GO:0016021"(integral component of membrane) refseq:NP_788276.1|refseq:NP_001265126.1|refseq:XP_011523599.1|refseq:NP_001265127.1|refseq:NP_001265145.1|refseq:NP_001265146.1|ensembl:ENSG00000108465(gene)|ensembl:ENST00000338399(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001889"(liver development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010921"(regulation of phosphatase activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030332"(cyclin binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060318"(definitive erythrocyte differentiation)|go:"GO:0071569"(protein ufmylation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1903363"(negative regulation of cellular protein catabolic process)|interpro:IPR008491(Protein of unknown function DUF773)|refseq:XP_016880653.1|refseq:XP_016880654.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:OvnNHpAMdBzncsAd5XLHj+j3fJ437296 rogid:K1S/DQ6fYeOm+MiiGicED0chJAw9606 rigid:W1ZL5pS9hNfYfC5EmSByFDcbxqs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98136 uniprotkb:P22830 intact:EBI-7922057|uniprotkb:Q2HRA2|intact:MINT-2824514 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:q98136_hhv8(display_long)|uniprotkb:ORF30(gene name)|psi-mi:ORF30(display_short)|uniprotkb:HHV8GK18_gp34(orf name) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063310|imex:IM-26114-133 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129383.1|interpro:IPR008002(Protein of unknown function DUF717) refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:YC136dcO0v7/sspLxSRZvCyfRrk37296 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 rigid:bw33xNCP9IvyyZNQCbtq6FSFxpQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98136 uniprotkb:O95721 intact:EBI-7922057|uniprotkb:Q2HRA2|intact:MINT-2824514 intact:EBI-490676|ensembl:ENSP00000215730 psi-mi:q98136_hhv8(display_long)|uniprotkb:ORF30(gene name)|psi-mi:ORF30(display_short)|uniprotkb:HHV8GK18_gp34(orf name) psi-mi:snp29_human(display_long)|uniprotkb:Vesicle-membrane fusion protein SNAP-29(gene name synonym)|uniprotkb:Soluble 29 kDa NSF attachment protein(gene name synonym)|uniprotkb:SNAP29(gene name)|psi-mi:SNAP29(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063310|imex:IM-26114-133 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129383.1|interpro:IPR008002(Protein of unknown function DUF717) refseq:NP_004773.1|ensembl:ENSG00000099940(gene)|ensembl:ENST00000215730(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019905"(syntaxin binding)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061025"(membrane fusion)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|mint:O95721|rcsb pdb:4WY4|rcsb pdb:7BV6|reactome:R-HSA-6798695|reactome:R-HSA-6811438|dip:DIP-56475N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:YC136dcO0v7/sspLxSRZvCyfRrk37296 rogid:4HyjERPnEDdBgiGt70N9oyrMN1k9606 rigid:bw33xNCP9IvyyZNQCbtq6FSFxpQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98136 uniprotkb:Q9ULH0 intact:EBI-7922057|uniprotkb:Q2HRA2|intact:MINT-2824514 intact:EBI-716681|uniprotkb:A1L4N4|intact:EBI-2798329|uniprotkb:Q6MZU2|uniprotkb:Q9H889|uniprotkb:Q9H9E4|uniprotkb:Q9NT37|uniprotkb:Q9UF42|uniprotkb:Q4VC08|ensembl:ENSP00000256707 psi-mi:q98136_hhv8(display_long)|uniprotkb:ORF30(gene name)|psi-mi:ORF30(display_short)|uniprotkb:HHV8GK18_gp34(orf name) psi-mi:kdis_human(display_long)|uniprotkb:KIAA1250(gene name synonym)|uniprotkb:KIDINS220(gene name)|psi-mi:KIDINS220(display_short)|uniprotkb:ARMS(gene name synonym)|uniprotkb:Ankyrin repeat-rich membrane-spanning protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063310|imex:IM-26114-133 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129383.1|interpro:IPR008002(Protein of unknown function DUF717) refseq:NP_065789.1|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000134313(gene)|ensembl:ENST00000256707(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR002110(Ankyrin)|interpro:IPR011646(KAP P-loop)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULH0|reactome:R-HSA-170984|reactome:R-HSA-9696270|reactome:R-HSA-9696273 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:YC136dcO0v7/sspLxSRZvCyfRrk37296 rogid:0wyaXuvXCqQTlfjuW4TAcIGmdlw9606 rigid:bw33xNCP9IvyyZNQCbtq6FSFxpQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98136 uniprotkb:P53801 intact:EBI-7922057|uniprotkb:Q2HRA2|intact:MINT-2824514 intact:EBI-3906138|uniprotkb:B2RDP7|uniprotkb:Q9NS09|uniprotkb:D3DSL9|ensembl:ENSP00000328325 psi-mi:q98136_hhv8(display_long)|uniprotkb:ORF30(gene name)|psi-mi:ORF30(display_short)|uniprotkb:HHV8GK18_gp34(orf name) psi-mi:pttg_human(display_long)|uniprotkb:PTTG1IP(gene name)|psi-mi:PTTG1IP(display_short)|uniprotkb:C21orf1(gene name synonym)|uniprotkb:C21orf3(gene name synonym)|uniprotkb:Pituitary tumor-transforming gene protein-binding factor(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063310|imex:IM-26114-133 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129383.1|interpro:IPR008002(Protein of unknown function DUF717) refseq:NP_004330.1|refseq:NP_001273751.1|ensembl:ENSG00000183255(gene)|ensembl:ENST00000330938(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR016201(Plexin-like fold)|interpro:IPR042492 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:YC136dcO0v7/sspLxSRZvCyfRrk37296 rogid:zxcMKOqV9drjMsK4XIdou4e5Wts9606 rigid:bw33xNCP9IvyyZNQCbtq6FSFxpQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O14773 uniprotkb:E5LBV4 intact:EBI-2800203|uniprotkb:Q5JAK6|uniprotkb:Q6UX56|uniprotkb:Q96C37|uniprotkb:Q71JP6|uniprotkb:Q53HT1|ensembl:ENSP00000299427 intact:EBI-14033503 psi-mi:tpp1_human(display_long)|uniprotkb:CLN2(gene name synonym)|uniprotkb:Tripeptidyl-peptidase I(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)|uniprotkb:Lysosomal pepstatin-insensitive protease(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 1 protein(gene name synonym)|uniprotkb:GIG1(orf name)|uniprotkb:UNQ267/PRO304(orf name)|uniprotkb:TPP1(gene name)|psi-mi:TPP1(display_short) psi-mi:e5lbv4_hhv8(display_long)|uniprotkb:ORF31(gene name)|psi-mi:ORF31(display_short)|uniprotkb:HHV8GK18_gp35(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063319|imex:IM-26114-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000382.3|ensembl:ENSG00000166340(gene)|ensembl:ENST00000299427(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0120146"(sulfatide binding)|go:"GO:1905146"(lysosomal protein catabolic process)|interpro:IPR015366(Peptidase S53, propeptide)|interpro:IPR030400|interpro:IPR036852|mint:O14773|rcsb pdb:1R60|rcsb pdb:3EDY|rcsb pdb:3EE6|reactome:R-HSA-381038|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|dip:DIP-47434N refseq:YP_001129384.1|interpro:IPR004289(UL92) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:lhbu2VS1TqFCwSf8XBd6U17K1sU9606 rogid:3mHxrPCiwxgtKW1jMQda7pbTPpw37296 rigid:2FsQWqfAeHHFu9qDYU8HnOs3m7o false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q98131 uniprotkb:P21912 intact:EBI-7922317|intact:MINT-2824661 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:q98131_hhv8(display_long)|uniprotkb:ORF34(gene name)|psi-mi:ORF34(display_short)|uniprotkb:HHV8GK18_gp38(orf name) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063325|imex:IM-26114-111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004280(UL95) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:xB1OWCPVHIa7vQrGisy/IZPpVBI37296 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:AdJ7XXBVbV1kHjqkPlFGhiT90pA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH5 uniprotkb:Q8NG31 intact:EBI-14063333|uniprotkb:Q2HR97 intact:EBI-1001161|intact:EBI-2555927|uniprotkb:Q8NHE1|uniprotkb:Q8WXA6|uniprotkb:Q9HCK2|uniprotkb:Q9NR92|ensembl:ENSP00000335463 psi-mi:q76rh5_hhv8(display_long)|uniprotkb:ORF35(gene name)|psi-mi:ORF35(display_short)|uniprotkb:HHV8GK18_gp39(orf name) psi-mi:knl1_human(display_long)|uniprotkb:KNL1(gene name)|psi-mi:KNL1(display_short)|uniprotkb:ALL1-fused gene from chromosome 15q14 protein(gene name synonym)|uniprotkb:Bub-linking kinetochore protein(gene name synonym)|uniprotkb:CASC5(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 5 protein(gene name synonym)|uniprotkb:Cancer/testis antigen 29(gene name synonym)|uniprotkb:KIAA1570(gene name synonym)|uniprotkb:Kinetochore-null protein 1(gene name synonym)|uniprotkb:Protein CASC5(gene name synonym)|uniprotkb:Protein D40/AF15q14(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063331|imex:IM-26114-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129388.1|interpro:IPR008566(Protein of unknown function DUF848, gammaherpesvirus) ensembl:ENSG00000137812(gene)|ensembl:ENST00000346991(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001675"(acrosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0016604"(nuclear body)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0051301"(cell division)|interpro:IPR037388|interpro:IPR040850|interpro:IPR043651|mint:Q8NG31|rcsb pdb:3SI5|rcsb pdb:4A1G|rcsb pdb:4NF9|rcsb pdb:4NFA|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_653091.3|refseq:NP_733468.3|ensembl:ENSP00000335463|ensembl:ENST00000399668|ensembl:ENSP00000382576|dip:DIP-36474N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:WTA52tu1TelrRN+RtKUHddME5cQ37296 rogid:VrKgxXm7DGkpFhJjZ98oQhkr5Eo9606 rigid:u+aI3NgElrsuap9NV4cKjKyx3LA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH5 uniprotkb:Q9NPF4 intact:EBI-14063333|uniprotkb:Q2HR97 intact:EBI-1056510|uniprotkb:Q6IAC3|ensembl:ENSP00000206542 psi-mi:q76rh5_hhv8(display_long)|uniprotkb:ORF35(gene name)|psi-mi:ORF35(display_short)|uniprotkb:HHV8GK18_gp39(orf name) psi-mi:osgep_human(display_long)|uniprotkb:"t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP"(gene name synonym)|uniprotkb:OSGEP(gene name)|psi-mi:OSGEP(display_short)|uniprotkb:GCPL1(gene name synonym)|uniprotkb:O-sialoglycoprotein endopeptidase(gene name synonym)|uniprotkb:tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP(gene name synonym)|uniprotkb:N6-L-threonylcarbamoyladenine synthase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063331|imex:IM-26114-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129388.1|interpro:IPR008566(Protein of unknown function DUF848, gammaherpesvirus) refseq:NP_060277.1|ensembl:ENSG00000092094(gene)|ensembl:ENST00000206542(transcript)|go:"GO:0000408"(EKC/KEOPS complex)|go:"GO:0002949"(tRNA threonylcarbamoyladenosine modification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0046872"(metal ion binding)|go:"GO:0061711"("N(6)-L-threonylcarbamoyladenine synthase activity")|interpro:IPR000905(Peptidase M22, glycoprotease)|interpro:IPR017860|interpro:IPR017861|interpro:IPR034680|interpro:IPR043129|mint:Q9NPF4|rcsb pdb:6GWJ|reactome:R-HSA-6782315 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:WTA52tu1TelrRN+RtKUHddME5cQ37296 rogid:gdWaUekKJ7WFXfPlaleW9Dpmsi89606 rigid:u+aI3NgElrsuap9NV4cKjKyx3LA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH5 uniprotkb:Q9H3G5 intact:EBI-14063333|uniprotkb:Q2HR97 intact:EBI-357542|uniprotkb:Q6UX20|uniprotkb:Q8NBL7|uniprotkb:Q96AR7|uniprotkb:Q9HB41|ensembl:ENSP00000265394|ensembl:ENSP00000379572|ensembl:ENSP00000387164|intact:EBI-1058665|uniprotkb:A4D1A4 psi-mi:q76rh5_hhv8(display_long)|uniprotkb:ORF35(gene name)|psi-mi:ORF35(display_short)|uniprotkb:HHV8GK18_gp39(orf name) psi-mi:cpvl_human(display_long)|uniprotkb:CPVL(gene name)|psi-mi:CPVL(display_short)|uniprotkb:VLP(gene name synonym)|uniprotkb:UNQ197/PRO223(orf name)|uniprotkb:PSEC0124(orf name)|uniprotkb:Carboxypeptidase, vitellogenic-like(gene name synonym)|uniprotkb:Vitellogenic carboxypeptidase-like protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063331|imex:IM-26114-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129388.1|interpro:IPR008566(Protein of unknown function DUF848, gammaherpesvirus) ensembl:ENSG00000106066(gene)|ensembl:ENST00000265394(transcript)|ensembl:ENST00000396276(transcript)|ensembl:ENST00000409850(transcript)|go:"GO:0004185"(serine-type carboxypeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001563(Peptidase S10, serine carboxypeptidase)|interpro:IPR018202|interpro:IPR029058|mint:Q9H3G5|refseq:NP_061902.2|refseq:NP_112601.3|refseq:XP_011513739.1|refseq:NP_001334981.1|refseq:NP_001334983.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:WTA52tu1TelrRN+RtKUHddME5cQ37296 rogid:antgab61u6D+KmbopQeowXqSqWQ9606 rigid:u+aI3NgElrsuap9NV4cKjKyx3LA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH5 uniprotkb:Q96QC0 intact:EBI-14063333|uniprotkb:Q2HR97 intact:EBI-1210346|uniprotkb:O00405|ensembl:ENSP00000365694|ensembl:ENSP00000373080|ensembl:ENSP00000389299|ensembl:ENSP00000407181|ensembl:ENSP00000407310|ensembl:ENSP00000413554|ensembl:ENSP00000416060 psi-mi:q76rh5_hhv8(display_long)|uniprotkb:ORF35(gene name)|psi-mi:ORF35(display_short)|uniprotkb:HHV8GK18_gp39(orf name) psi-mi:pp1ra_human(display_long)|uniprotkb:PPP1R10(gene name)|psi-mi:PPP1R10(display_short)|uniprotkb:CAT53(gene name synonym)|uniprotkb:FB19(gene name synonym)|uniprotkb:PNUTS(gene name synonym)|uniprotkb:Phosphatase 1 nuclear targeting subunit(gene name synonym)|uniprotkb:MHC class I region proline-rich protein CAT53(gene name synonym)|uniprotkb:Protein FB19(gene name synonym)|uniprotkb:PP1-binding protein of 114 kDa(gene name synonym)|uniprotkb:p99(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063331|imex:IM-26114-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129388.1|interpro:IPR008566(Protein of unknown function DUF848, gammaherpesvirus) refseq:XP_011513024.1|refseq:NP_002705.2|refseq:XP_006715193.1|refseq:XP_016866484.1|dip:DIP-39343N|ensembl:ENSG00000204569(gene)|ensembl:ENSG00000206489(gene)|ensembl:ENSG00000227804(gene)|ensembl:ENSG00000230995(gene)|ensembl:ENSG00000231737(gene)|ensembl:ENSG00000235291(gene)|ensembl:ENSG00000238104(gene)|ensembl:ENST00000376511(transcript)|ensembl:ENST00000383586(transcript)|ensembl:ENST00000420949(transcript)|ensembl:ENST00000424446(transcript)|ensembl:ENST00000426299(transcript)|ensembl:ENST00000429597(transcript)|ensembl:ENST00000449113(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016604"(nuclear body)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0046872"(metal ion binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:1904290"(negative regulation of mitotic DNA damage checkpoint)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR017923|interpro:IPR035441|interpro:IPR036855|mint:Q96QC0|go:"GO:0000785"(chromatin) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:WTA52tu1TelrRN+RtKUHddME5cQ37296 rogid:ZWueXxqNFYPT0WhbfYdR3d2H2G89606 rigid:u+aI3NgElrsuap9NV4cKjKyx3LA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH5 uniprotkb:P42568 intact:EBI-14063333|uniprotkb:Q2HR97 intact:EBI-716132|uniprotkb:B1AMQ2|uniprotkb:D3DRJ8|intact:EBI-11060385|ensembl:ENSP00000369695|intact:EBI-749963|uniprotkb:B2R7B3|uniprotkb:B7Z755|uniprotkb:Q8IVB0 psi-mi:q76rh5_hhv8(display_long)|uniprotkb:ORF35(gene name)|psi-mi:ORF35(display_short)|uniprotkb:HHV8GK18_gp39(orf name) psi-mi:af9_human(display_long)|uniprotkb:ALL1-fused gene from chromosome 9 protein(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein(gene name synonym)|uniprotkb:YEATS domain-containing protein 3(gene name synonym)|uniprotkb:MLLT3(gene name)|psi-mi:MLLT3(display_short)|uniprotkb:AF9(gene name synonym)|uniprotkb:YEATS3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063331|imex:IM-26114-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129388.1|interpro:IPR008566(Protein of unknown function DUF848, gammaherpesvirus) refseq:NP_004520.2|refseq:NP_001273620.1|ensembl:ENSG00000171843(gene)|ensembl:ENST00000380338(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0007379"(segment specification)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010467"(gene expression)|go:"GO:0042393"(histone binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1902275"(regulation of chromatin organization)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|mint:P42568|rcsb pdb:2LM0|rcsb pdb:2MV7|rcsb pdb:2N4Q|rcsb pdb:2NDF|rcsb pdb:2NDG|rcsb pdb:4TMP|rcsb pdb:5HJB|rcsb pdb:5HJD|rcsb pdb:5YYF|rcsb pdb:6B7G|rcsb pdb:6L5Z|rcsb pdb:6LS6|rcsb pdb:6MIL|rcsb pdb:6MIM|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|dip:DIP-56409N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:WTA52tu1TelrRN+RtKUHddME5cQ37296 rogid:Z+g2iDUI+CzIrL7bMjY11hYKywQ9606 rigid:u+aI3NgElrsuap9NV4cKjKyx3LA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q8WY36 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-6425236|uniprotkb:A2RRM7|uniprotkb:Q8WY35|uniprotkb:Q8NDB0|uniprotkb:Q7LBY8|uniprotkb:Q2TAJ1|uniprotkb:Q9H0J6|uniprotkb:Q7L3J8|ensembl:ENSP00000319974 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:bbx_human(display_long)|uniprotkb:BBX(gene name)|psi-mi:BBX(display_short)|uniprotkb:Bobby sox homolog(gene name synonym)|uniprotkb:HBP2(gene name synonym)|uniprotkb:HMG box-containing protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_001263215.1|refseq:XP_011511302.1|refseq:XP_011511303.1|refseq:XP_011511306.1|refseq:NP_001136040.1|refseq:NP_064620.2|refseq:XP_005247699.1|refseq:XP_005247700.1|refseq:XP_005247701.1|refseq:XP_016862370.1|refseq:XP_016862371.1|ensembl:ENSG00000114439(gene)|ensembl:ENST00000325805(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0060348"(bone development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR019102|interpro:IPR036910 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:IjEKkdmyIKspTlZ+C3wCXKIfbn09606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q7L0Y3 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2107046|uniprotkb:Q9NRG5|uniprotkb:Q9NX54|uniprotkb:Q9Y596|ensembl:ENSP00000312356 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:tm10c_human(display_long)|uniprotkb:TRMT10C(gene name)|psi-mi:TRMT10C(display_short)|uniprotkb:HBV pre-S2 trans-regulated protein 2(gene name synonym)|uniprotkb:MRPP1(gene name synonym)|uniprotkb:RG9MTD1(gene name synonym)|uniprotkb:"RNA (guanine-9-)-methyltransferase domain-containing protein 1"(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-49(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 1(gene name synonym)|uniprotkb:"mRNA methyladenosine-N(1)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (adenine(9)-N(1))-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (guanine(9)-N(1))-methyltransferase"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_060289.2|ensembl:ENSG00000174173(gene)|ensembl:ENST00000309922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009019"("tRNA (guanine-N1-)-methyltransferase activity")|go:"GO:0016429"("tRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0052905"("tRNA (guanine(9)-N(1))-methyltransferase activity")|go:"GO:0061953"("mRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090646"(mitochondrial tRNA processing)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR007356("tRNA (guanine-N1-)-methyltransferase, eukaryotic")|interpro:IPR016009("tRNA (guanine-N1-)-methyltransferase")|interpro:IPR025812|interpro:IPR028564|interpro:IPR038459|mint:Q7L0Y3|rcsb pdb:5NFJ|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-8868766 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:ZvCWxNlWBon4eDq2zgzVTk3dI7U9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q14694 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q9UII4 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2339540|uniprotkb:B2RTQ1|uniprotkb:Q69G20|intact:EBI-28975860|ensembl:ENSP00000264350 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:herc5_human(display_long)|uniprotkb:HERC5(gene name)|psi-mi:HERC5(display_short)|uniprotkb:CEB1(gene name synonym)|uniprotkb:CEBP1(gene name synonym)|uniprotkb:HECT domain and RCC1-like domain-containing protein 5(gene name synonym)|uniprotkb:Cyclin-E-binding protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) ensembl:ENSP00000264350|refseq:NP_057407.2|dip:DIP-44200N|ensembl:ENSG00000138646(gene)|ensembl:ENST00000264350(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000569(HECT)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR035983|mint:Q9UII4|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-936440|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:IGuce5qcdMB8PC5u6b6A57FODKY9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q7KZI7 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:P82932 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-716172|uniprotkb:Q96Q64|uniprotkb:Q9BSK8|uniprotkb:Q9BW89|uniprotkb:B2R573|ensembl:ENSP00000382250 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:rt06_human(display_long)|uniprotkb:MRPS6(gene name)|psi-mi:MRPS6(display_short)|uniprotkb:C21orf101(gene name synonym)|uniprotkb:RPMS6(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein bS6m(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_115865.1|ensembl:ENSG00000243927(gene)|ensembl:ENST00000399312(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0070181"(small ribosomal subunit rRNA binding)|interpro:IPR000529(Ribosomal protein S6)|interpro:IPR014717(Translation elongation factor EF1B/ribosomal protein S6)|interpro:IPR035980|mint:P82932|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZSA|rcsb pdb:6ZS9|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:mMPTr45GZxT1pj2RBZvvG6TrQmo9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q9Y291 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2688704|ensembl:ENSP00000320567|ensembl:ENSP00000376732|ensembl:ENSP00000417287|ensembl:ENSP00000418451 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:rt33_human(display_long)|uniprotkb:MRPS33(gene name)|psi-mi:MRPS33(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS33(gene name synonym)|uniprotkb:CGI-139(orf name)|uniprotkb:PTD003(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_057155.1|refseq:NP_444263.1|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|ensembl:ENSG00000090263(gene)|ensembl:ENST00000324787(transcript)|ensembl:ENST00000393008(transcript)|ensembl:ENST00000469351(transcript)|ensembl:ENST00000496958(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|interpro:IPR013219(Ribosomal protein S27, mitochondrial)|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:lKeun672/ySI/pp5aA7KfONA2wM9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q8N3Y7 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-3923480|uniprotkb:Q8TDV9|uniprotkb:Q96LX1|uniprotkb:B4DGK2|uniprotkb:Q330K3|ensembl:ENSP00000307607 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:rdhe2_human(display_long)|uniprotkb:SDR16C5(gene name)|psi-mi:SDR16C5(display_short)|uniprotkb:RDHE2(gene name synonym)|uniprotkb:Retinal short-chain dehydrogenase reductase 2(gene name synonym)|uniprotkb:Short-chain dehydrogenase/reductase family 16C member 5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_620419.2|ensembl:ENSG00000170786(gene)|ensembl:ENST00000303749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004745"(NAD-retinol dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042574"(retinal metabolic process)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR036291|reactome:R-HSA-5365859|refseq:NP_001304978.1|refseq:NP_001304979.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:QZpkWx5jhIwubrQu9Dvq2Vtw7KA9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q8NC60 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-717871|uniprotkb:Q8N7L6|uniprotkb:Q9BSQ9|ensembl:ENSP00000264230 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:noa1_human(display_long)|uniprotkb:NOA1(gene name)|psi-mi:NOA1(display_short)|uniprotkb:C4orf14(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_115689.1|ensembl:ENSG00000084092(gene)|ensembl:ENST00000264230(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010941"(regulation of cell death)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0043457"(regulation of cellular respiration)|interpro:IPR006073(GTP1/OBG)|interpro:IPR027417|interpro:IPR030378 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:lynfPNtWZ/q7Df9/hpwiyIjUD2Y9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q96EL2 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-1055789|uniprotkb:P82668|uniprotkb:Q96Q23|uniprotkb:Q9P047|uniprotkb:A4D1U9|ensembl:ENSP00000318158 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:rt24_human(display_long)|uniprotkb:bMRP-47(gene name synonym)|uniprotkb:MRPS24(gene name)|psi-mi:MRPS24(display_short)|uniprotkb:HSPC335(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein uS3m(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_114403.1|ensembl:ENSG00000062582(gene)|ensembl:ENST00000317534(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR026146|mint:Q96EL2|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:OEtFmhoLM1Sw9YVrL88HZQ5Ju0g9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:P79522 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2803328|uniprotkb:Q5RJB5|uniprotkb:Q5STN6|uniprotkb:A1A4H4|ensembl:ENSP00000365744|ensembl:ENSP00000373086|ensembl:ENSP00000392826|ensembl:ENSP00000396416|ensembl:ENSP00000398352|ensembl:ENSP00000402596|ensembl:ENSP00000415432 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:prr3_human(display_long)|uniprotkb:CAT56(gene name synonym)|uniprotkb:MHC class I region proline-rich protein CAT56(gene name synonym)|uniprotkb:PRR3(gene name)|psi-mi:PRR3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_079539.2|ensembl:ENSG00000204576(gene)|ensembl:ENSG00000206491(gene)|ensembl:ENSG00000223766(gene)|ensembl:ENSG00000223887(gene)|ensembl:ENSG00000228186(gene)|ensembl:ENSG00000229202(gene)|ensembl:ENSG00000233564(gene)|ensembl:ENST00000376560(transcript)|ensembl:ENST00000383592(transcript)|ensembl:ENST00000427729(transcript)|ensembl:ENST00000432371(transcript)|ensembl:ENST00000449754(transcript)|ensembl:ENST00000453232(transcript)|ensembl:ENST00000454399(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR042805 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:bcAKyQnrxJvEB6z7wAfU7MxJyRQ9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:O75127 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2560233|uniprotkb:Q66K60|uniprotkb:Q9UDV2|uniprotkb:Q3ZB78|intact:EBI-28971087|ensembl:ENSP00000292478 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:ptcd1_human(display_long)|uniprotkb:PTCD1(gene name)|psi-mi:PTCD1(display_short)|uniprotkb:KIAA0632(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_056360.2|ensembl:ENSP00000292478|ensembl:ENSG00000106246(gene)|ensembl:ENST00000292478(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0042780"(tRNA 3'-end processing)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|dip:DIP-56845N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:NkS3D5M+poxihNXmc5GnqkSSYnk9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q9Y2Z4 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-1049286|uniprotkb:Q9H817|uniprotkb:D3DUW8|ensembl:ENSP00000320658 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:syym_human(display_long)|uniprotkb:YARS2(gene name)|psi-mi:YARS2(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:CGI-04(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_001035526.1|ensembl:ENSG00000139131(gene)|ensembl:ENST00000324868(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016604"(nuclear body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043039"(tRNA aminoacylation)|go:"GO:0070184"(mitochondrial tyrosyl-tRNA aminoacylation)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR024088|interpro:IPR036986|rcsb pdb:2PID|rcsb pdb:3ZXI|reactome:R-HSA-379726|dip:DIP-29487N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:cTNOZVenqyzWUlHTF7XLcZIKV+s9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:Q05469 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-721601|uniprotkb:Q3LRT2|uniprotkb:Q6NSL7|ensembl:ENSP00000244289 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:lips_human(display_long)|uniprotkb:LIPE(gene name)|psi-mi:LIPE(display_short)|uniprotkb:Monoacylglycerol lipase LIPE(gene name synonym)|uniprotkb:Retinyl ester hydrolase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_005348.2|go:"GO:0046485"(ether lipid metabolic process)|go:"GO:0047372"(acylglycerol lipase activity)|go:"GO:0047376"(all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity)|go:"GO:0050253"(retinyl-palmitate esterase activity)|go:"GO:0102258"(1,3-diacylglycerol acylhydrolase activity)|go:"GO:0102259"(1,2-diacylglycerol acylhydrolase activity)|interpro:IPR002168(Lipase, GDXG, active site)|interpro:IPR010468(Hormone-sensitive lipase, N-terminal)|interpro:IPR013094(Alpha/beta hydrolase fold-3)|interpro:IPR029058|interpro:IPR033140|reactome:R-HSA-163560|ensembl:ENSG00000079435(gene)|ensembl:ENST00000244289(transcript)|go:"GO:0004771"(sterol esterase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0033878"(hormone-sensitive lipase activity)|go:"GO:0046340"(diacylglycerol catabolic process)|refseq:XP_005258997.1|refseq:XP_006723281.1|refseq:XP_016882299.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:pfJlMy3xEXQDx6URLLc+TBOURNs9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH4 uniprotkb:O95900 intact:EBI-14063350|uniprotkb:Q2HR96 intact:EBI-2560154|uniprotkb:B7Z7G5|ensembl:ENSP00000361982 psi-mi:q76rh4_hhv8(display_long)|uniprotkb:ORF36(gene name)|psi-mi:ORF36(display_short)|uniprotkb:HHV8GK18_gp40(orf name) psi-mi:trub2_human(display_long)|uniprotkb:TRUB2(gene name)|psi-mi:TRUB2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063348|imex:IM-26114-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|refseq:YP_001129389.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core) refseq:NP_056494.1|ensembl:ENSG00000167112(gene)|ensembl:ENST00000372890(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006397"(mRNA processing)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR020103|interpro:IPR039048|refseq:NP_001316790.1|refseq:NP_001316791.1|refseq:NP_001316792.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A4Dwov4p1egBbiHIWh/PmGZPoOE37296 rogid:AaucuWPDUoPto8+AMkDpvtQZ3XQ9606 rigid:+KRpun8I/9kyvI/c85Zgv35KO1E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:Q96FX7 intact:EBI-14063380 intact:EBI-934042|uniprotkb:Q8N7Q9|uniprotkb:A6NN78|ensembl:ENSP00000374399 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:trm61_human(display_long)|uniprotkb:TRMT61A(gene name)|psi-mi:TRMT61A(display_short)|uniprotkb:C14orf172(gene name synonym)|uniprotkb:TRM61(gene name synonym)|uniprotkb:"tRNA(m1A58)-methyltransferase subunit TRMT61A"(gene name synonym)|uniprotkb:"mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_689520.2|ensembl:ENSG00000166166(gene)|ensembl:ENST00000389749(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016429"("tRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0031515"("tRNA (m1A) methyltransferase complex")|go:"GO:0061953"("mRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0080009"(mRNA methylation)|interpro:IPR014816(tRNA methyltransferase complex GCD14 subunit)|interpro:IPR029063|rcsb pdb:5CCB|rcsb pdb:5CCX|rcsb pdb:5CD1|reactome:R-HSA-6782315 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:kQBsaqAmJg1LHJU5HGPPwBG1L3s9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:P78346 intact:EBI-14063380 intact:EBI-366553|uniprotkb:B2R799|uniprotkb:E9PB02|ensembl:ENSP00000360768 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:rpp30_human(display_long)|uniprotkb:RPP30(gene name)|psi-mi:RPP30(display_short)|uniprotkb:RNASEP2(gene name synonym)|uniprotkb:RNase P subunit 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_001098016.1|refseq:NP_006404.1|refseq:XP_011537422.1|refseq:XP_011537423.1|ensembl:ENSG00000148688(gene)|ensembl:ENST00000371703(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0001682"(tRNA 5'-leader removal)|go:"GO:0003723"(RNA binding)|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0006364"(rRNA processing)|go:"GO:0008033"(tRNA processing)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR002738(RNase P subunit p30)|interpro:IPR016195(Polymerase and histidinol phosphatase-like)|mint:P78346|rcsb pdb:6AHR|rcsb pdb:6AHU|reactome:R-HSA-6784531|reactome:R-HSA-6791226|refseq:XP_016870964.1|refseq:XP_016870966.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:pRHvUnpzpNHGzYbS+kRiSa0m71E9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:O75818 intact:EBI-14063380 intact:EBI-366505|uniprotkb:Q8WVK8|uniprotkb:Q5VX97|ensembl:ENSP00000369391 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:rpp40_human(display_long)|uniprotkb:RPP40(gene name)|psi-mi:RPP40(display_short)|uniprotkb:RNASEP1(gene name synonym)|uniprotkb:RNase P subunit 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_001273061.1|refseq:NP_001273062.1|refseq:NP_006629.2|go:"GO:0005655"(nucleolar ribonuclease P complex)|go:"GO:0030681"(multimeric ribonuclease P complex)|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:1905267"(endonucleolytic cleavage involved in tRNA processing)|interpro:IPR013893(Ribonuclease P, Rpp40)|rcsb pdb:6AHR|rcsb pdb:6AHU|rcsb pdb:6AHV|reactome:R-HSA-6784531|reactome:R-HSA-6791226|go:"GO:0004526"(ribonuclease P activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000124787(gene)|ensembl:ENST00000380051(transcript)|go:"GO:0000172"(ribonuclease MRP complex)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001682"(tRNA 5'-leader removal) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:osKnYk6H7n8lXec/a3T38grQsFE9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:P0C0P6 intact:EBI-14063380 intact:EBI-14063404|ensembl:ENSP00000381105 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:nps_human(display_long)|uniprotkb:NPS(gene name)|psi-mi:NPS(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_001025184.1|ensembl:ENSG00000214285(gene)|ensembl:ENST00000398023(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0010841"(positive regulation of circadian sleep/wake cycle, wakefulness)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|interpro:IPR028138|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-9660821 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:PHcdF1Xe2PUEXn60B889BejFDZQ9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:Q9NRL2 intact:EBI-14063380 intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:P55265 intact:EBI-14063380 intact:EBI-2462104|uniprotkb:B1AQR0|uniprotkb:O15223|uniprotkb:O43859|uniprotkb:O43860|uniprotkb:Q9BYM3|uniprotkb:Q9BYM4|uniprotkb:B1AQQ9|uniprotkb:D3DV76|ensembl:ENSP00000357459 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:dsrad_human(display_long)|uniprotkb:ADAR(gene name)|psi-mi:ADAR(display_short)|uniprotkb:ADAR1(gene name synonym)|uniprotkb:DSRAD(gene name synonym)|uniprotkb:G1P1(gene name synonym)|uniprotkb:IFI4(gene name synonym)|uniprotkb:136 kDa double-stranded RNA-binding protein(gene name synonym)|uniprotkb:K88DSRBP(gene name synonym)|uniprotkb:Interferon-inducible protein 4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_001020278.1|refseq:NP_001102.2|refseq:NP_001180424.1|refseq:NP_056655.2|refseq:NP_056656.2|refseq:XP_006711174.1|refseq:XP_006711175.1|refseq:XP_006711176.1|dip:DIP-29310N|ensembl:ENSG00000160710(gene)|ensembl:ENST00000368474(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002566"(somatic diversification of immune receptors via somatic mutation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003726"(double-stranded RNA adenosine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006382"(adenosine to inosine editing)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008251"(tRNA-specific adenosine deaminase activity)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0016553"(base conversion or substitution editing)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900369"(negative regulation of RNA interference)|interpro:IPR002466(Adenosine deaminase/editase)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036388|interpro:IPR036390|interpro:IPR042371|interpro:IPR044456|interpro:IPR044457|mint:P55265|rcsb pdb:1QBJ|rcsb pdb:1QGP|rcsb pdb:1XMK|rcsb pdb:2ACJ|rcsb pdb:2GXB|rcsb pdb:2L54|rcsb pdb:2MDR|rcsb pdb:3F21|rcsb pdb:3F22|rcsb pdb:3F23|rcsb pdb:3IRQ|rcsb pdb:3IRR|rcsb pdb:5ZU1|rcsb pdb:5ZUO|rcsb pdb:5ZUP|rcsb pdb:7C0I|reactome:R-HSA-75102|reactome:R-HSA-77042|reactome:R-HSA-909733|go:"GO:0051607"(defense response to virus) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:rP/Yr/h8WLSFNdIuqWnYtZjZ9qI9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:Q9H7B2 intact:EBI-14063380 intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)") - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZP9 uniprotkb:Q96PZ0 intact:EBI-14063380 intact:EBI-1052964|uniprotkb:Q75MG4|uniprotkb:Q9NX19|ensembl:ENSP00000348722|ensembl:ENSP00000417402 psi-mi:d0uzp9_hhv8(display_long)|uniprotkb:ORF37(gene name)|psi-mi:ORF37(display_short)|uniprotkb:HHV8GK18_gp41(orf name) psi-mi:pus7_human(display_long)|uniprotkb:PUS7(gene name)|psi-mi:PUS7(display_short)|uniprotkb:KIAA1897(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063378|imex:IM-26114-155 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|interpro:IPR001616(Alphaherpesvirus alkaline exonuclease)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR034720 refseq:NP_061915.2|refseq:NP_001305092.1|refseq:NP_001305093.1|interpro:IPR001656(tRNA pseudouridine synthase D)|interpro:IPR011760(tRNA pseudouridine synthase D, core)|interpro:IPR020103|interpro:IPR020119|interpro:IPR042214|rcsb pdb:5KKP|reactome:R-HSA-6782315|go:"GO:2000380"(regulation of mesoderm development)|ensembl:ENSG00000091127(gene)|ensembl:ENST00000356362(transcript)|ensembl:ENST00000469408(transcript)|go:"GO:0001522"(pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031119"(tRNA pseudouridine synthesis)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990481"(mRNA pseudouridine synthesis)|refseq:XP_005250519.1|refseq:XP_016867856.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:D9vtrHWfbxRI4isMmYDAnTJQSZs37296 rogid:dqaw2O1w02FX+bVTYIZq9pVwNOQ9606 rigid:nKPqb7jejNo88+9naDu/Yduni9I false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:Q96MW5 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-720875|ensembl:ENSP00000305459|uniprotkb:Q8WVV6|uniprotkb:Q9H6F8|uniprotkb:Q0VAK2 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:cog8_human(display_long)|uniprotkb:Component of oligomeric Golgi complex 8(gene name synonym)|uniprotkb:COG8(gene name)|psi-mi:COG8(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) ensembl:ENSG00000213380(gene)|ensembl:ENST00000306875(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0032588"(trans-Golgi network membrane)|interpro:IPR007255(Dor1-like protein)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR016632(Conserved oligomeric Golgi complex, COG8)|mint:Q96MW5|reactome:R-HSA-6807878|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_115758.3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:X9AZmEQ+B2Jc9kwFXAgxZp6S0sI9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:Q9BTE7 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-3924013|uniprotkb:Q3ZTT2|ensembl:ENSP00000260247 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:dcnl5_human(display_long)|uniprotkb:DCUN1D5(gene name)|psi-mi:DCUN1D5(display_short)|uniprotkb:DCUN1 domain-containing protein 5(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 5(gene name synonym)|uniprotkb:SCCRO5(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene 5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) refseq:NP_115675.1|ensembl:ENST00000260247(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|reactome:R-HSA-8951664|ensembl:ENSG00000137692(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:EDYg7Tn8nZY4IPid4ZckCJ3e20M9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:Q15172 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-641666|uniprotkb:Q2NL72|uniprotkb:Q5VVB2|uniprotkb:Q8TBI9|uniprotkb:B2R6D2|uniprotkb:D3DT99|uniprotkb:B7Z7L2|ensembl:ENSP00000261461 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:2a5a_human(display_long)|uniprotkb:PP2A B subunit isoform B'-alpha(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-alpha(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-alpha(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-alpha(gene name synonym)|uniprotkb:PPP2R5A(gene name)|psi-mi:PPP2R5A(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) refseq:NP_001186685.1|refseq:NP_006234.1|dip:DIP-459N|reactome:R-HSA-9648025|reactome:R-HSA-68877|ensembl:ENSG00000066027(gene)|ensembl:ENST00000261461(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0090219"(negative regulation of lipid kinase activity)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q15172|rcsb pdb:6NTS|reactome:R-HSA-141444|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-2467813|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-5675221|reactome:R-HSA-6811558 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:DpFpGFjwzJej//cr7ciShgzJpCE9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:Q5QP82 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-723230|uniprotkb:A4VCJ5|uniprotkb:Q32NE2|uniprotkb:Q96ET5|uniprotkb:Q9BTQ5|uniprotkb:Q9H5P6|uniprotkb:Q8N2Q5|ensembl:ENSP00000366953|intact:EBI-2559068 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:dca10_human(display_long)|uniprotkb:DCAF10(gene name)|psi-mi:DCAF10(display_short)|uniprotkb:WDR32(gene name synonym)|uniprotkb:WD repeat-containing protein 32(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) refseq:NP_077321.3|ensembl:ENSG00000122741(gene)|ensembl:ENST00000377724(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039085|mint:Q5QP82|reactome:R-HSA-8951664|interpro:IPR001680(WD40 repeat)|refseq:NP_001273739.1|refseq:XP_005251634.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:0mrMrjLK7HAJLVaAg/spKCEKOAo9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:P50897 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH3 uniprotkb:Q7L1Q6 intact:EBI-14033513|uniprotkb:Q2HR94 intact:EBI-1046727|ensembl:ENSP00000386474|intact:EBI-1051097|uniprotkb:Q14281|uniprotkb:Q15394|uniprotkb:Q9BUY0|uniprotkb:B4DLZ8|uniprotkb:B4DWF7|intact:EBI-21351780 psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:bzw1_human(display_long)|uniprotkb:BZW1(gene name)|psi-mi:BZW1(display_short)|uniprotkb:BZAP45(gene name synonym)|uniprotkb:KIAA0005(gene name synonym)|uniprotkb:Protein Orf(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063426|imex:IM-26114-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) refseq:NP_001193996.1|refseq:NP_055485.2|ensembl:ENSG00000082153(gene)|ensembl:ENST00000409600(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510|mint:Q7L1Q6|refseq:NP_001193997.1|refseq:NP_001193998.1|refseq:NP_001308617.1|refseq:NP_001308619.1|refseq:NP_001308620.1|refseq:NP_001308622.1|refseq:NP_001308623.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rogid:4dzFp6AN4tymPA5rHNYlHCCmSaY9606 rigid:0PlfoPfr81hGzW7W+hOPdD3Y3C8 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40931 uniprotkb:P46108 intact:EBI-2608673|uniprotkb:Q2HR93 intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791 psi-mi:o40931_hhv8(display_long)|uniprotkb:ORF39(gene name)|psi-mi:ORF39(display_short)|uniprotkb:gM(gene name synonym)|uniprotkb:HHV8GK18_gp43(orf name) psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063437|imex:IM-26114-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000785(Herpsevirus integral membrane protein)|refseq:YP_001129392.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0055036"(virion membrane) ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:67bpFNnadSqtGImtvPWws2me1BI37296 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 rigid:9w5OxZAVK1EsZB7aToA5OkXZsgE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40931 uniprotkb:P62993 intact:EBI-2608673|uniprotkb:Q2HR93 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:o40931_hhv8(display_long)|uniprotkb:ORF39(gene name)|psi-mi:ORF39(display_short)|uniprotkb:gM(gene name synonym)|uniprotkb:HHV8GK18_gp43(orf name) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063437|imex:IM-26114-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000785(Herpsevirus integral membrane protein)|refseq:YP_001129392.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0055036"(virion membrane) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:67bpFNnadSqtGImtvPWws2me1BI37296 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 rigid:9w5OxZAVK1EsZB7aToA5OkXZsgE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:P55060 intact:EBI-14063446 intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q8TCG1 intact:EBI-14063446 intact:EBI-1379376|uniprotkb:B9EGC3|uniprotkb:A1L4J7|uniprotkb:Q6P4G6|uniprotkb:Q8WVP8|uniprotkb:Q96PI2|uniprotkb:Q9H9C6|uniprotkb:Q9P204|ensembl:ENSP00000295746 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:cip2a_human(display_long)|uniprotkb:CIP2A(gene name)|psi-mi:CIP2A(display_short)|uniprotkb:Cancerous inhibitor of PP2A(gene name synonym)|uniprotkb:KIAA1524(gene name synonym)|uniprotkb:p90 autoantigen(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:XP_006713780.1|refseq:NP_065941.2|refseq:XP_011511358.1|ensembl:ENSG00000163507(gene)|ensembl:ENST00000295746(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042510|rcsb pdb:5UFL - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:L9bS1Ko7hMRa/pYXVI0Gvybco8s9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q8N878 intact:EBI-14063446 intact:EBI-11749206|uniprotkb:B2RNV8|uniprotkb:B3KUM6|uniprotkb:Q5SZU7|uniprotkb:Q9UFB0|ensembl:ENSP00000283309 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:frmd1_human(display_long)|uniprotkb:FRMD1(gene name)|psi-mi:FRMD1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001116313.1|refseq:NP_079195.3|refseq:XP_011534448.1|ensembl:ENSG00000153303(gene)|ensembl:ENST00000283309(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|refseq:XP_016866807.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:WYKuqk6Xg2zO0VH2lLcIBoCaVWc9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:P38606 intact:EBI-14063446 intact:EBI-1054757|intact:EBI-10982175|uniprotkb:Q53YD9|uniprotkb:Q96DY6|uniprotkb:Q9UHY3|uniprotkb:B2RBR8|uniprotkb:B7Z1R5|uniprotkb:D3DN75|ensembl:ENSP00000273398 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:vata_human(display_long)|uniprotkb:Vacuolar proton pump subunit alpha(gene name synonym)|uniprotkb:V-ATPase 69 kDa subunit(gene name synonym)|uniprotkb:Vacuolar ATPase isoform VA68(gene name synonym)|uniprotkb:ATP6V1A(gene name)|psi-mi:ATP6V1A(display_short)|uniprotkb:ATP6A1(gene name synonym)|uniprotkb:ATP6V1A1(gene name synonym)|uniprotkb:VPP2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001681.2|ensembl:ENSG00000114573(gene)|ensembl:ENST00000273398(transcript)|go:"GO:0000221"(vacuolar proton-transporting V-type ATPase, V1 domain)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016469"(proton-transporting two-sector ATPase complex)|go:"GO:0030133"(transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005725(ATPase, V1 complex, subunit A)|interpro:IPR020003|interpro:IPR022878|interpro:IPR023366|interpro:IPR024034|interpro:IPR027417|interpro:IPR031686|interpro:IPR036121|mint:P38606|rcsb pdb:6WLZ|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-1222556|reactome:R-HSA-77387|reactome:R-HSA-917977|reactome:R-HSA-9639288|reactome:R-HSA-983712 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:GqPRFwsl5tDH83kpE8Al7NiYWrI9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9UIA9 intact:EBI-14063446 intact:EBI-286668|uniprotkb:O94846|uniprotkb:Q6PJK9|uniprotkb:Q8NEK7|ensembl:ENSP00000252512 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:xpo7_human(display_long)|uniprotkb:Ran-binding protein 16(gene name synonym)|uniprotkb:XPO7(gene name)|psi-mi:XPO7(display_short)|uniprotkb:KIAA0745(gene name synonym)|uniprotkb:RANBP16(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_055839.3|ensembl:ENSG00000130227(gene)|ensembl:ENST00000252512(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040021|interpro:IPR044189|mint:Q9UIA9 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:v+DQUTgId55XuRlCPZ4tq7fIing9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q7Z4Q2 intact:EBI-14063446 intact:EBI-1051903|uniprotkb:Q8N525|uniprotkb:Q8WV56|uniprotkb:Q96CC9|uniprotkb:Q9NWN7|uniprotkb:A8K1N4|ensembl:ENSP00000299192 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:heat3_human(display_long)|uniprotkb:HEATR3(gene name)|psi-mi:HEATR3(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_891552.1|ensembl:ENSG00000155393(gene)|ensembl:ENST00000299192(transcript)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR016024(Armadillo-type fold)|mint:Q7Z4Q2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:CjdYLKIHc/A29+XYy4VjNNHJSRU9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9Y5L0 intact:EBI-14063446 intact:EBI-1042571|uniprotkb:A4D1K9|uniprotkb:Q6NUM1|uniprotkb:Q96G71|uniprotkb:Q96GU9|uniprotkb:Q9Y3R2|uniprotkb:C9IZM0|ensembl:ENSP00000265388 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:tnpo3_human(display_long)|uniprotkb:TNPO3(gene name)|psi-mi:TNPO3(display_short)|uniprotkb:IPO12(gene name synonym)|uniprotkb:Transportin-SR(gene name synonym)|uniprotkb:Importin-12(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001177957.2|refseq:NP_036602.1|ensembl:ENSG00000064419(gene)|ensembl:ENST00000265388(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Y5L0|rcsb pdb:4C0O|rcsb pdb:4C0P|rcsb pdb:4C0Q|rcsb pdb:4OL0|rcsb pdb:6GX9 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:Xvd5fZ4wlMc6R6w2wL+JhIOOuIE9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9UBB4 intact:EBI-14063446 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q86VP6 intact:EBI-14063446 intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q96QU8 intact:EBI-14063446 intact:EBI-1022896|uniprotkb:Q2YDX3|uniprotkb:Q53G88|uniprotkb:Q68G50|uniprotkb:Q76N88|uniprotkb:Q96CP8|uniprotkb:Q9BT21|ensembl:ENSP00000302790|uniprotkb:A1L3W4|uniprotkb:D3DWF9 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:xpo6_human(display_long)|uniprotkb:Ran-binding protein 20(gene name synonym)|uniprotkb:XPO6(gene name)|psi-mi:XPO6(display_short)|uniprotkb:KIAA0370(gene name synonym)|uniprotkb:RANBP20(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) ensembl:ENSG00000169180(gene)|ensembl:ENST00000304658(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|refseq:NP_001257869.1|refseq:NP_055986.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040016 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:WWmEHILNukjT/WJ/ZQsru4To/lc9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9BTW9 intact:EBI-14063446 intact:EBI-356005|uniprotkb:O95458|uniprotkb:Q7L8K1|uniprotkb:Q8IXP6|uniprotkb:Q8NAX0|uniprotkb:Q8WYH4|uniprotkb:Q96E74|uniprotkb:Q9UF82|uniprotkb:Q9UG46|uniprotkb:Q9Y2J3|intact:EBI-2555162|intact:EBI-2562220|ensembl:ENSP00000347719 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:tbcd_human(display_long)|uniprotkb:TBCD(gene name)|psi-mi:TBCD(display_short)|uniprotkb:KIAA0988(gene name synonym)|uniprotkb:SSD1(gene name synonym)|uniprotkb:TFCD(gene name synonym)|uniprotkb:PP1096(orf name)|uniprotkb:Tubulin-folding cofactor D(gene name synonym)|uniprotkb:Beta-tubulin cofactor D(gene name synonym)|uniprotkb:SSD-1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_005984.3|ensembl:ENSG00000141556(gene)|ensembl:ENST00000355528(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005874"(microtubule)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007023"(post-chaperonin tubulin folding pathway)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0051087"(chaperone binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022577|interpro:IPR033162|mint:Q9BTW9|reactome:R-HSA-389977 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:9idLpkQy9EORh88FUMLul3LU3Yg9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q96ER3 intact:EBI-14063446 intact:EBI-721193|uniprotkb:A6NH05|ensembl:ENSP00000432487 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:saal1_human(display_long)|uniprotkb:Synoviocyte proliferation-associated in collagen-induced arthritis protein 1(gene name synonym)|uniprotkb:SAAL1(gene name)|psi-mi:SAAL1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_612430.2|ensembl:ENSG00000166788(gene)|ensembl:ENST00000524803(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:/zDVy3k3FVjctiLf1XeIeWHL9BE9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:O14787 intact:EBI-14063446 intact:EBI-431907|uniprotkb:O14655|intact:EBI-1053477|uniprotkb:Q6IN77|ensembl:ENSP00000407182|ensembl:ENSP00000468434 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:tnpo2_human(display_long)|uniprotkb:Karyopherin beta-2b(gene name synonym)|uniprotkb:TNPO2(gene name)|psi-mi:TNPO2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001129668.1|refseq:NP_001129667.1|refseq:NP_038461.2|ensembl:ENSG00000105576(gene)|ensembl:ENST00000425528(transcript)|ensembl:ENST00000592287(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:B+ZqD5TWiP/J6/ZwiM+39lO9E749606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9UI26 intact:EBI-14063446 intact:EBI-748752|uniprotkb:B4DZ73|uniprotkb:Q8N5R2|uniprotkb:Q9NSJ6|uniprotkb:Q9NVB1|uniprotkb:A6NGJ5|uniprotkb:D3DW98|ensembl:ENSP00000316651 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:ipo11_human(display_long)|uniprotkb:Ran-binding protein 11(gene name synonym)|uniprotkb:IPO11(gene name)|psi-mi:IPO11(display_short)|uniprotkb:RANBP11(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001128251.1|refseq:NP_057422.3|ensembl:ENSG00000086200(gene)|ensembl:ENST00000325324(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9UI26 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:OTTaVDNCpSJLcEJCkdb7f+DkADo9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9Y6E2 intact:EBI-14063446 intact:EBI-1051021|uniprotkb:Q3B779|uniprotkb:Q9H3F7|uniprotkb:A4D123|uniprotkb:Q96JW5|ensembl:ENSP00000258761|ensembl:ENSP00000397249 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:bzw2_human(display_long)|uniprotkb:BZW2(gene name)|psi-mi:BZW2(display_short)|uniprotkb:HSPC028(orf name)|uniprotkb:MSTP017(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001153239.1|refseq:NP_054757.1|ensembl:ENSG00000136261(gene)|ensembl:ENST00000258761(transcript)|ensembl:ENST00000433922(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510|refseq:XP_006715769.1|refseq:XP_006715770.1|refseq:XP_006715771.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:+z22Ykb6e3IM9zk51m6tjuhiEcU9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:O00429 intact:EBI-14063446 intact:EBI-724571|uniprotkb:O14541|uniprotkb:O60709|uniprotkb:Q7L6B3|uniprotkb:Q8TBT7|uniprotkb:Q9BWM1|uniprotkb:Q9Y5J2|uniprotkb:B4DSU8|uniprotkb:A8K4X9|ensembl:ENSP00000450399|uniprotkb:B4DGC9|uniprotkb:J3KPI2|uniprotkb:Q59GN9|uniprotkb:G8JLD5 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:dnm1l_human(display_long)|uniprotkb:Dynamin-like protein(gene name synonym)|uniprotkb:Dnm1p/Vps1p-like protein(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym)|uniprotkb:Dynamin-like protein 4(gene name synonym)|uniprotkb:Dynamin-like protein IV(gene name synonym)|uniprotkb:DNM1L(gene name)|psi-mi:DNM1L(display_short)|uniprotkb:DLP1(gene name synonym)|uniprotkb:DRP1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_005681.2|refseq:NP_036192.2|refseq:NP_036193.2|ensembl:ENSG00000087470(gene)|ensembl:ENST00000549701(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016020"(membrane)|go:"GO:0016559"(peroxisome fission)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036466"(synaptic vesicle recycling via endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048511"(rhythmic process)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051433"(BH2 domain binding)|go:"GO:0060047"(heart contraction)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070266"(necroptotic process)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090149"(mitochondrial membrane fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903578"(regulation of ATP metabolic process)|go:"GO:1904579"(cellular response to thapsigargin)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1905395"(response to flavonoid)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|interpro:IPR030556|mint:O00429|rcsb pdb:3W6N|rcsb pdb:3W6O|rcsb pdb:3W6P|rcsb pdb:4BEJ|rcsb pdb:4H1U|rcsb pdb:4H1V|rcsb pdb:5WP9|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:1900063"(regulation of peroxisome organization)|reactome:R-HSA-75153|refseq:NP_001265392.1|refseq:NP_001265393.1|refseq:NP_001265394.1|refseq:NP_001265395.1|refseq:NP_001317309.1|dip:DIP-42704N - - crc64:F9521A376B785B71 figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:hmh7m80FPMdx6/3eUY6l0IK/AqY9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q96G23 intact:EBI-14063446 intact:EBI-1057080|uniprotkb:Q9HD96|uniprotkb:Q9NW79|uniprotkb:D3DV06|uniprotkb:Q5SZE5|ensembl:ENSP00000271688|ensembl:ENSP00000357950 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:cers2_human(display_long)|uniprotkb:CERS2(gene name)|psi-mi:CERS2(display_short)|uniprotkb:TMSG1(gene name synonym)|uniprotkb:Tumor metastasis-suppressor gene 1 protein(gene name synonym)|uniprotkb:SP260(gene name synonym)|uniprotkb:LASS2(gene name synonym)|uniprotkb:LAG1 longevity assurance homolog 2(gene name synonym)|uniprotkb:Sphingosine N-acyltransferase CERS2(gene name synonym)|uniprotkb:Very-long-chain ceramide synthase CERS2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:XP_011507754.1|refseq:NP_071358.1|refseq:NP_859530.1|ensembl:ENSG00000143418(gene)|ensembl:ENST00000271688(transcript)|ensembl:ENST00000368954(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050291"(sphingosine N-acyltransferase activity)|go:"GO:1900148"(negative regulation of Schwann cell migration)|interpro:IPR001356(Homeobox)|interpro:IPR006634(TRAM, LAG1 and CLN8 homology)|interpro:IPR009057(Homeodomain-like)|interpro:IPR016439(Longevity assurance, LAG1/LAC1)|mint:Q96G23|reactome:R-HSA-1660661|go:"GO:1905045"(negative regulation of Schwann cell proliferation involved in axon regeneration) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:Eqxvp+41fFXPr+hpqRQsLB6Lq4M9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q86U38 intact:EBI-14063446 intact:EBI-5456022|uniprotkb:Q8IVF0|uniprotkb:Q8TBS6|intact:EBI-8293740|intact:MINT-8407174|uniprotkb:A8MY76|ensembl:ENSP00000267425|ensembl:ENSP00000495668 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:nop9_human(display_long)|uniprotkb:NOP9(gene name)|psi-mi:NOP9(display_short)|uniprotkb:C14orf21(gene name synonym)|uniprotkb:KIAA2021(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_001273296.1|refseq:NP_777573.1|ensembl:ENSG00000196943(gene)|ensembl:ENSG00000285326(gene)|ensembl:ENST00000267425(transcript)|ensembl:ENST00000644840(transcript)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040000|mint:Q86U38 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:dJjEtwyK4x6qVx2dW0MzS7tqDYI9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9P000 intact:EBI-14063446 intact:EBI-1550510|uniprotkb:Q9H0R0|uniprotkb:Q96FI2|uniprotkb:E9PAN2|ensembl:ENSP00000263401 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:comd9_human(display_long)|uniprotkb:COMMD9(gene name)|psi-mi:COMMD9(display_short)|uniprotkb:HSPC166(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_054905.2|refseq:NP_001294866.1|ensembl:ENSG00000110442(gene)|ensembl:ENST00000263401(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006814"(sodium ion transport)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR017920|interpro:IPR037360|rcsb pdb:4NKN|rcsb pdb:4OE9|rcsb pdb:6BP6|reactome:R-HSA-6798695|reactome:R-HSA-8951664 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:2MhNQZU+OGXGZ2nuSi1AS8+bpz09606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q9C0E2 intact:EBI-14063446 intact:EBI-1044855|uniprotkb:Q5VUZ5|uniprotkb:Q9H934|uniprotkb:Q8N3V6|ensembl:ENSP00000255305 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:xpo4_human(display_long)|uniprotkb:XPO4(gene name)|psi-mi:XPO4(display_short)|uniprotkb:KIAA1721(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_071904.4|ensembl:ENSG00000132953(gene)|ensembl:ENST00000255305(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR044189|mint:Q9C0E2|go:"GO:0005643"(nuclear pore) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:+7lQFg9CBnDLFt9rqjLb//HPJnQ9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:O95219 intact:EBI-14063446 intact:EBI-724909|uniprotkb:D3DNA3|uniprotkb:B4DQV4|uniprotkb:B3KMH0|ensembl:ENSP00000251775 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:snx4_human(display_long)|uniprotkb:SNX4(gene name)|psi-mi:SNX4(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_003785.1|ensembl:ENSG00000114520(gene)|ensembl:ENST00000251775(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|interpro:IPR001683(Phox-like)|interpro:IPR027267|interpro:IPR034783|interpro:IPR034902|interpro:IPR036871|interpro:IPR037430|dip:DIP-36719N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:Y/Dg8VrUYYvI5Xf67D3unhCjLDA9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:P0C0L4 intact:EBI-14063446 intact:EBI-1223619|uniprotkb:P01028|uniprotkb:P78445|uniprotkb:Q13160|uniprotkb:Q13906|uniprotkb:Q14033|uniprotkb:Q14835|uniprotkb:Q5JQM8|uniprotkb:Q9NPK5|uniprotkb:Q9UIP5|uniprotkb:B0QZR6|uniprotkb:A6H8M8|uniprotkb:A6NHJ5|uniprotkb:A7E2V2|uniprotkb:B0V2C8|uniprotkb:B2RUT6|uniprotkb:B7ZVZ6|uniprotkb:Q4LE82|uniprotkb:Q5JNX2|uniprotkb:Q6P4R1|uniprotkb:Q6U2E5|uniprotkb:Q6U2E8|uniprotkb:Q6U2F0|uniprotkb:Q6U2F3|uniprotkb:Q6U2F4|uniprotkb:Q6U2F6|uniprotkb:Q6U2F8|uniprotkb:Q6U2G0|uniprotkb:Q96EG2|uniprotkb:Q96SA8|ensembl:ENSP00000388662|ensembl:ENSP00000396688|ensembl:ENSP00000372815 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:co4a_human(display_long)|uniprotkb:C4A(gene name)|psi-mi:C4A(display_short)|uniprotkb:CO4(gene name synonym)|uniprotkb:CPAMD2(gene name synonym)|uniprotkb:Acidic complement C4(gene name synonym)|uniprotkb:C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_009224.2|refseq:NP_001002029.3|refseq:NP_001239133.1|ensembl:ENSG00000206340(gene)|ensembl:ENSG00000227746(gene)|ensembl:ENSG00000244731(gene)|ensembl:ENST00000383325(transcript)|ensembl:ENST00000421274(transcript)|ensembl:ENST00000428956(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006956"(complement activation)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR001840(Complement C3a/C4a/C5a anaphylatoxin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR019742|interpro:IPR036595|interpro:IPR037569|interpro:IPR040839|interpro:IPR041555|rcsb pdb:1HZF|rcsb pdb:4FXG|rcsb pdb:4FXK|rcsb pdb:4XAM|rcsb pdb:5JPM|rcsb pdb:5JPN|rcsb pdb:5JTW|reactome:R-HSA-166663|reactome:R-HSA-174577|reactome:R-HSA-381426|reactome:R-HSA-8957275|reactome:R-HSA-977606 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:nLlIFlW5RCngnXASkYPGREjA/1E9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q969Z0 intact:EBI-14063446 intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q06136 intact:EBI-14063446 intact:EBI-3909166|uniprotkb:B2R5Y1|ensembl:ENSP00000494352|uniprotkb:B4DMX0 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:kdsr_human(display_long)|uniprotkb:KDSR(gene name)|psi-mi:KDSR(display_short)|uniprotkb:FVT1(gene name synonym)|uniprotkb:3-dehydrosphinganine reductase(gene name synonym)|uniprotkb:Follicular variant translocation protein 1(gene name synonym)|uniprotkb:SDR35C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 35C member 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_002026.1|ensembl:ENST00000645214(transcript)|ensembl:ENSG00000119537(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006666"(3-keto-sphinganine metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0047560"(3-dehydrosphinganine reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q06136|reactome:R-HSA-1660661 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:Qeo5s672s/qK8CE52sS1Pr01kFY9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HFG5 uniprotkb:Q15386 intact:EBI-14063446 intact:EBI-1058871|uniprotkb:A4D235|uniprotkb:A6NCP3|uniprotkb:Q8TC15|uniprotkb:Q96CR4|uniprotkb:Q9UDU3|intact:EBI-1237492|ensembl:ENSP00000309198 psi-mi:f5hfg5_hhv8(display_long)|uniprotkb:ORF4(gene name)|psi-mi:ORF4(display_short)|uniprotkb:HHV8GK18_gp02(orf name) psi-mi:ube3c_human(display_long)|uniprotkb:UBE3C(gene name)|psi-mi:UBE3C(display_short)|uniprotkb:KIAA0010(gene name synonym)|uniprotkb:KIAA10(gene name synonym)|uniprotkb:HectH2(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3C(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063444|imex:IM-26114-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR035976|refseq:YP_001129351.1|interpro:IPR000436(Sushi/SCR/CCP) refseq:NP_055486.2|ensembl:ENSG00000009335(gene)|ensembl:ENST00000348165(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000569(HECT)|interpro:IPR035983|interpro:IPR044611|rcsb pdb:6K2C|reactome:R-HSA-983168|go:"GO:0000502"(proteasome complex) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:jz6Ld34PJwUAoFIJ6sxt0V9cJZA37296 rogid:dgGb2MVtbVnFuuUAnlX4YIT39lE9606 rigid:usC2Q/MQ8qVHhXpQm1/ede8ifV0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P22392 uniprotkb:Q76RH1 intact:EBI-713693|ensembl:ENSP00000376886|ensembl:ENSP00000421064|ensembl:ENSP00000425581|ensembl:ENSP00000426901|ensembl:ENSP00000426976|uniprotkb:A8MWA3|uniprotkb:Q1WM23|uniprotkb:Q6LCT6 intact:EBI-14063483|uniprotkb:Q2HR91 psi-mi:ndkb_human(display_long)|uniprotkb:nm23-H2(gene name synonym)|uniprotkb:C-myc purine-binding transcription factor PUF(gene name synonym)|uniprotkb:NME2(gene name)|psi-mi:NME2(display_short)|uniprotkb:NM23B(gene name synonym)|uniprotkb:Histidine protein kinase NDKB(gene name synonym) psi-mi:q76rh1_hhv8(display_long)|uniprotkb:ORF42(gene name)|psi-mi:ORF42(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063481|imex:IM-26114-113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243678(gene)|ensembl:ENST00000393190(transcript)|ensembl:ENST00000503064(transcript)|ensembl:ENST00000512737(transcript)|ensembl:ENST00000513177(transcript)|ensembl:ENST00000514264(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_001018146.1|refseq:NP_001018147.1|refseq:NP_001018148.1|refseq:NP_001018149.1|refseq:NP_002503.1|dip:DIP-50179N|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:P22392|rcsb pdb:1NSK|rcsb pdb:1NUE|rcsb pdb:3BBB|rcsb pdb:3BBC|rcsb pdb:3BBF|reactome:R-HSA-499943|reactome:R-HSA-6798695|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm) interpro:IPR002600(Herpesvirus UL7-like protein)|refseq:YP_001129394.1|go:"GO:0019033"(viral tegument)|go:"GO:0044177"(host cell Golgi apparatus) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:GHHfoXOuc25KIJJqiW9r+OWm5Kk9606 rogid:ScwaDsi+LjM2ZAudHsIGn/0NGuQ37296 rigid:6bif/DqDvrfklGbfc2bpKRM+c+4 false - c-venus:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH0 uniprotkb:Q86T65 intact:EBI-14063498|uniprotkb:Q2HR90 intact:EBI-2684862|uniprotkb:Q5T4U0|uniprotkb:Q9Y4G0|uniprotkb:Q9NQI5|uniprotkb:Q5T4T8|uniprotkb:G5EA45|ensembl:ENSP00000274867|ensembl:ENSP00000381876 psi-mi:q76rh0_hhv8(display_long)|uniprotkb:ORF43(gene name)|psi-mi:ORF43(display_short)|uniprotkb:HHV8GK18_gp45(orf name) psi-mi:daam2_human(display_long)|uniprotkb:KIAA0381(gene name synonym)|uniprotkb:DAAM2(gene name)|psi-mi:DAAM2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063496|imex:IM-26114-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129395.1|interpro:IPR002660(Herpesvirus UL6 like)|go:"GO:0006323"(DNA packaging)|go:"GO:0019076"(viral release from host cell)|go:"GO:0042025"(host cell nucleus) refseq:NP_001188356.1|refseq:NP_056160.2|ensembl:ENST00000274867(transcript)|ensembl:ENST00000398904(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0021516"(dorsal spinal cord development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042201|ensembl:ENSG00000146122(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:QaFu+/Lk/E5PT+vidaZE6TslOKs37296 rogid:zAMR7kGamUednJzFGFSXbwvHbAo9606 rigid:0c+Ry77QmZAobdyKJwdmc+1YRfg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RH0 uniprotkb:P20073 intact:EBI-14063498|uniprotkb:Q2HR90 intact:EBI-2338704|uniprotkb:Q5F2H3|uniprotkb:Q5T0M6|uniprotkb:Q5T0M7|intact:EBI-28973842|ensembl:ENSP00000362010 psi-mi:q76rh0_hhv8(display_long)|uniprotkb:ORF43(gene name)|psi-mi:ORF43(display_short)|uniprotkb:HHV8GK18_gp45(orf name) psi-mi:anxa7_human(display_long)|uniprotkb:ANXA7(gene name)|psi-mi:ANXA7(display_short)|uniprotkb:ANX7(gene name synonym)|uniprotkb:SNX(gene name synonym)|uniprotkb:Annexin-7(gene name synonym)|uniprotkb:Annexin VII(gene name synonym)|uniprotkb:Synexin(gene name synonym)|uniprotkb:OK/SW-cl.95(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063496|imex:IM-26114-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129395.1|interpro:IPR002660(Herpesvirus UL6 like)|go:"GO:0006323"(DNA packaging)|go:"GO:0019076"(viral release from host cell)|go:"GO:0042025"(host cell nucleus) ensembl:ENSP00000362010|ensembl:ENST00000372921|ensembl:ENSP00000362012|refseq:NP_001147.1|refseq:NP_004025.1|refseq:XP_016871651.1|refseq:XP_016871652.1|ensembl:ENSG00000138279(gene)|ensembl:ENST00000372919(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061025"(membrane fusion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:QaFu+/Lk/E5PT+vidaZE6TslOKs37296 rogid:ad3I49rhRoZ0hG8ruDgSQWocVuw9606 rigid:0c+Ry77QmZAobdyKJwdmc+1YRfg false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P57772 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-7950757|uniprotkb:Q96HZ6|intact:UNK-5380960|ensembl:ENSP00000254730|ensembl:ENSP00000494933 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:selb_human(display_long)|uniprotkb:EEFSEC(gene name)|psi-mi:EEFSEC(display_short)|uniprotkb:SELB(gene name synonym)|uniprotkb:Elongation factor sec(gene name synonym)|uniprotkb:Eukaryotic elongation factor, selenocysteine-tRNA-specific(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_068756.2|ensembl:ENSG00000132394(gene)|ensembl:ENSG00000284869(gene)|ensembl:ENST00000254730(transcript)|ensembl:ENST00000644579(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006414"(translational elongation)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR027417|rcsb pdb:5IZK|rcsb pdb:5IZL|rcsb pdb:5IZM|reactome:R-HSA-2408557 - - comment:mint|function:Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP|comment:homomint figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:71jGLXhhos7exnM0+0P8+cbhei09606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q96C12 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-6425121|ensembl:ENSP00000268314|ensembl:ENSP00000456877|uniprotkb:Q86WM9|uniprotkb:Q9H925|uniprotkb:Q9H7P8 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:armc5_human(display_long)|uniprotkb:ARMC5(gene name)|psi-mi:ARMC5(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSG00000140691(gene)|ensembl:ENST00000268314(transcript)|ensembl:ENST00000563544(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0016020"(membrane)|go:"GO:0035801"(adrenal cortex development)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0051607"(defense response to virus)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000225(Armadillo)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001288749.1|refseq:NP_001275696.1|refseq:NP_001098717.1|refseq:NP_079018.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:ZmP+cRk6jHF3CzosogoO2kQOnF89606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q01433 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-8796759|uniprotkb:Q16687|uniprotkb:Q96IA1|uniprotkb:Q14856|uniprotkb:Q16688|uniprotkb:Q16729|uniprotkb:E9PNG0|uniprotkb:B4DK50|uniprotkb:Q9UDX8|uniprotkb:Q5T693|uniprotkb:Q5T695|uniprotkb:Q9UMU4|uniprotkb:Q14857|uniprotkb:Q16686|uniprotkb:Q9UDX9|uniprotkb:B4DZI5 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:ampd2_human(display_long)|uniprotkb:AMP deaminase isoform L(gene name synonym)|uniprotkb:AMPD2(gene name)|psi-mi:AMPD2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 interpro:IPR029749|go:"GO:0003876"(AMP deaminase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006188"(IMP biosynthetic process)|go:"GO:0032264"(IMP salvage)|go:"GO:0042802"(identical protein binding)|go:"GO:0046033"(AMP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0052652"(cyclic purine nucleotide metabolic process)|go:"GO:0097009"(energy homeostasis)|interpro:IPR032466|rcsb pdb:4NO3|rcsb pdb:4NO5|refseq:NP_001295099.1|reactome:R-HSA-74217|interpro:IPR001365(Adenosine/AMP deaminase)|interpro:IPR006329(AMP deaminase)|interpro:IPR006650(Adenosine/AMP deaminase active site)|refseq:NP_001244289.1|refseq:NP_001244290.1|refseq:NP_004028.3|refseq:NP_631895.1|refseq:NP_981949.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:RtwaG2tgYyPx0rerl76Zs/qgHsw9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q709F0 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-2880718|ensembl:ENSP00000264990|uniprotkb:Q8WUT6|uniprotkb:Q08AF0|uniprotkb:Q658Y2|uniprotkb:Q658N9|uniprotkb:Q6ZND2|uniprotkb:Q9H9R3 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:acd11_human(display_long)|uniprotkb:ACAD11(gene name)|psi-mi:ACAD11(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSG00000240303(gene)|ensembl:ENST00000264990(transcript)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR002575(Aminoglycoside phosphotransferase)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|interpro:IPR041726|mint:Q709F0|rcsb pdb:2WBI|reactome:R-HSA-77289|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|refseq:NP_115545.3 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:Qknz1ZNcvX0q/3f5TuGQkJ6oHSk9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q8IUQ4 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-747107|uniprotkb:O43269|uniprotkb:Q49A58|uniprotkb:A0FKF3|uniprotkb:Q92880|ensembl:ENSP00000369343|ensembl:ENSP00000378214|ensembl:ENSP00000456421 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:siah1_human(display_long)|uniprotkb:Seven in absentia homolog 1(gene name synonym)|uniprotkb:Siah-1a(gene name synonym)|uniprotkb:SIAH1(gene name)|psi-mi:SIAH1(display_short)|uniprotkb:HUMSIAH(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SIAH1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:XP_006721309.1|refseq:NP_001006611.1|refseq:NP_003022.3|refseq:XP_011521581.1|ensembl:ENST00000380006(transcript)|ensembl:ENST00000394725(transcript)|ensembl:ENST00000568007(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|mint:Q8IUQ4|rcsb pdb:2A25|rcsb pdb:4C9Z|rcsb pdb:4CA1|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D|rcsb pdb:4X3G|rcsb pdb:5WZZ|reactome:R-HSA-373752|reactome:R-HSA-977225|reactome:R-HSA-983168|ensembl:ENSG00000196470(gene)|dip:DIP-35684N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:O6+z1g9K1ij87Xgo5/Ykl5Q3vUQ9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P28482 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-959949|ensembl:ENSP00000215832|ensembl:ENSP00000381803|uniprotkb:A8CZ64 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:mk01_human(display_long)|uniprotkb:MAPK1(gene name)|psi-mi:MAPK1(display_short)|uniprotkb:ERK2(gene name synonym)|uniprotkb:PRKM1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)|uniprotkb:PRKM2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 reactome:R-HSA-112411|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-437239|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|refseq:NP_002736.3|refseq:NP_620407.1|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P28482|rcsb pdb:1PME|go:"GO:0072686"(mitotic spindle)|rcsb pdb:1TVO|rcsb pdb:1WZY|rcsb pdb:2OJG|rcsb pdb:2OJI|rcsb pdb:2OJJ|rcsb pdb:2Y9Q|rcsb pdb:3D42|rcsb pdb:3D44|rcsb pdb:3I5Z|rcsb pdb:3I60|rcsb pdb:3SA0|rcsb pdb:3TEI|rcsb pdb:3W55|rcsb pdb:4FMQ|rcsb pdb:4FUX|rcsb pdb:4FUY|rcsb pdb:4FV0|rcsb pdb:4FV1|rcsb pdb:4FV2|rcsb pdb:4FV3|rcsb pdb:4FV4|rcsb pdb:4FV5|rcsb pdb:4FV6|rcsb pdb:4FV7|rcsb pdb:4FV8|rcsb pdb:4FV9|rcsb pdb:4G6N|rcsb pdb:4G6O|rcsb pdb:4H3P|rcsb pdb:4H3Q|rcsb pdb:4IZ5|rcsb pdb:4IZ7|rcsb pdb:4IZA|rcsb pdb:4N0S|rcsb pdb:4NIF|rcsb pdb:4O6E|rcsb pdb:4QP1|rcsb pdb:4QP2|rcsb pdb:4QP3|rcsb pdb:4QP4|rcsb pdb:4QP6|rcsb pdb:4QP7|rcsb pdb:4QP8|rcsb pdb:4QP9|rcsb pdb:4QPA|rcsb pdb:4QTA|rcsb pdb:4QTE|rcsb pdb:4XJ0|rcsb pdb:4ZXT|rcsb pdb:4ZZM|rcsb pdb:4ZZN|rcsb pdb:4ZZO|rcsb pdb:5AX3|rcsb pdb:5BUE|rcsb pdb:5BUI|rcsb pdb:5BUJ|rcsb pdb:5BVD|rcsb pdb:5BVE|rcsb pdb:5BVF|rcsb pdb:5K4I|rcsb pdb:5LCJ|rcsb pdb:5LCK|rcsb pdb:5NGU|rcsb pdb:5NHF|rcsb pdb:5NHH|rcsb pdb:5NHJ|rcsb pdb:5NHL|rcsb pdb:5NHO|rcsb pdb:5NHP|rcsb pdb:5NHV|rcsb pdb:5V60|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:5WP1|rcsb pdb:6D5Y|rcsb pdb:6DMG|rcsb pdb:6G54|rcsb pdb:6G8X|rcsb pdb:6G91|rcsb pdb:6G92|rcsb pdb:6G93|rcsb pdb:6G97|rcsb pdb:6G9A|rcsb pdb:6G9D|rcsb pdb:6G9H|rcsb pdb:6G9J|rcsb pdb:6G9K|rcsb pdb:6G9M|rcsb pdb:6G9N|rcsb pdb:6GDM|rcsb pdb:6GDQ|rcsb pdb:6GE0|rcsb pdb:6GJB|rcsb pdb:6GJD|rcsb pdb:6NBS|rcsb pdb:6OPG|rcsb pdb:6OPH|rcsb pdb:6OPI|rcsb pdb:6Q7K|rcsb pdb:6Q7S|rcsb pdb:6Q7T|rcsb pdb:6QA1|rcsb pdb:6QA3|rcsb pdb:6QA4|rcsb pdb:6QAG|rcsb pdb:6QAH|rcsb pdb:6QAL|rcsb pdb:6QAQ|rcsb pdb:6QAW|rcsb pdb:6RQ4|rcsb pdb:6SLG|reactome:R-HSA-111995|reactome:R-HSA-112409|ensembl:ENSG00000100030(gene)|ensembl:ENST00000215832(transcript)|ensembl:ENST00000398822(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634635|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9652817|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|dip:DIP-519N|ensembl:ENSP00000215832|ensembl:ENSP00000381803|ensembl:ENST00000544786|ensembl:ENSP00000440842 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:odzhd70I/8uWedx0+gF38lhe60I9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:O43255 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-948141|uniprotkb:O43270|ensembl:ENSP00000322457 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:siah2_human(display_long)|uniprotkb:Seven in absentia homolog 2(gene name synonym)|uniprotkb:SIAH2(gene name)|psi-mi:SIAH2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase SIAH2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_005058.3|dip:DIP-41874N|ensembl:ENSG00000181788(gene)|ensembl:ENST00000312960(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|rcsb pdb:5H9M|reactome:R-HSA-373752|reactome:R-HSA-5689880|reactome:R-HSA-977225|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:1AUfjiUQFAEsOkxiSwdWZX4aPbY9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q8WWI1 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-350367|uniprotkb:O15462|uniprotkb:O95346|uniprotkb:Q9UKC1|uniprotkb:Q9UQM5|uniprotkb:Q9Y6A7|uniprotkb:Q5TBK6|uniprotkb:E9PLH4 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:lmo7_human(display_long)|uniprotkb:LMO7(gene name)|psi-mi:LMO7(display_short)|uniprotkb:FBX20(gene name synonym)|uniprotkb:FBXO20(gene name synonym)|uniprotkb:KIAA0858(gene name synonym)|uniprotkb:F-box only protein 20(gene name synonym)|uniprotkb:LOMP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_005349.3|refseq:NP_056667.2|refseq:NP_001293009.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023051"(regulation of signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR003096(SM22/calponin)|interpro:IPR029978|interpro:IPR031865|interpro:IPR036034|interpro:IPR036872|rcsb pdb:2EAQ|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENST00000341547|ensembl:ENSP00000342112|ensembl:ENSG00000136153|refseq:NP_001317512.1|mint:Q8WWI1|dip:DIP-33107N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:d8c3oZaqaloIUBqxgvpNI3PP2fU9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P27361 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-73995|uniprotkb:B0LPG3|uniprotkb:A8CZ58|uniprotkb:Q8NHX1|ensembl:ENSP00000263025 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:mk03_human(display_long)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:MAPK3(gene name)|psi-mi:MAPK3(display_short)|uniprotkb:ERK1(gene name synonym)|uniprotkb:PRKM3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_001035145.1|refseq:NP_001103361.1|refseq:NP_002737.2|dip:DIP-30985N|ensembl:ENSG00000102882(gene)|ensembl:ENST00000263025(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P27361|rcsb pdb:2ZOQ|rcsb pdb:4QTB|rcsb pdb:6GES|reactome:R-HSA-110056|reactome:R-HSA-112409|reactome:R-HSA-1169408|reactome:R-HSA-1295596|reactome:R-HSA-162658|reactome:R-HSA-170968|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2029482|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2871796|reactome:R-HSA-3371453|reactome:R-HSA-375165|reactome:R-HSA-444257|reactome:R-HSA-445144|reactome:R-HSA-450341|reactome:R-HSA-456926|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5663213|reactome:R-HSA-5668599|reactome:R-HSA-5673001|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-6811558|reactome:R-HSA-73728|reactome:R-HSA-74749|reactome:R-HSA-879415|reactome:R-HSA-881907|reactome:R-HSA-8939211|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9627069|reactome:R-HSA-9634638|reactome:R-HSA-9635465|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|reactome:R-HSA-9664422|reactome:R-HSA-982772|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:PGxmRMz0kOsJTfdn21FBiF33YwI9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q01167 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-2509991|intact:EBI-28976610|ensembl:ENSP00000335677|uniprotkb:Q13624|uniprotkb:Q13623|uniprotkb:A6NEP5|uniprotkb:Q13622 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:foxk2_human(display_long)|uniprotkb:G/T-mismatch specific binding protein(gene name synonym)|uniprotkb:FOXK2(gene name)|psi-mi:FOXK2(display_short)|uniprotkb:ILF(gene name synonym)|uniprotkb:ILF1(gene name synonym)|uniprotkb:Interleukin enhancer-binding factor 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSG00000141568(gene)|ensembl:ENST00000335255(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|go:"GO:0061621"(canonical glycolysis)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:Q01167|rcsb pdb:1JXS|rcsb pdb:2C6Y|reactome:R-HSA-5689603|ensembl:ENSP00000335677|ensembl:ENST00000473637|ensembl:ENSP00000436108|refseq:NP_004505.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:mGYtlnM3enVAuU82j5hQ0sui3F49606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q9BXF6 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-1387068|uniprotkb:O94939|uniprotkb:Q9P0M1|ensembl:ENSP00000258098 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:rfip5_human(display_long)|uniprotkb:RAB11FIP5(gene name)|psi-mi:RAB11FIP5(display_short)|uniprotkb:GAF1(gene name synonym)|uniprotkb:KIAA0857(gene name synonym)|uniprotkb:RIP11(gene name synonym)|uniprotkb:Rab11-interacting protein Rip11(gene name synonym)|uniprotkb:Gamma-SNAP-associated factor 1(gene name synonym)|uniprotkb:Phosphoprotein pp75(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_056285.1|ensembl:ENSG00000135631(gene)|ensembl:ENST00000258098(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0030141"(secretory granule)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070164"(negative regulation of adiponectin secretion)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR019018|interpro:IPR035892|interpro:IPR037245|interpro:IPR037789|mint:Q9BXF6|go:"GO:0034451"(centriolar satellite) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:X3eYUlRpL+nSmU4gfUEA5RntseY9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P26358 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q93009 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P85037 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-2509974|ensembl:ENSP00000328720 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:foxk1_human(display_long)|uniprotkb:FOXK1(gene name)|psi-mi:FOXK1(display_short)|uniprotkb:MNF(gene name synonym)|uniprotkb:Myocyte nuclear factor(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSG00000164916(gene)|ensembl:ENST00000328914(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0042594"(response to starvation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5689603|refseq:XP_011513493.1|refseq:NP_001032242.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:ngoE3oNlIDGkTf1ZMYG4OQ6lvE09606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q15349 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-1384149|uniprotkb:Q15419|uniprotkb:Q59GJ3|uniprotkb:Q5TI68|uniprotkb:Q96J38|uniprotkb:Q9UJN5|uniprotkb:B3KTK9|ensembl:ENSP00000265678 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:ks6a2_human(display_long)|uniprotkb:RPS6KA2(gene name)|psi-mi:RPS6KA2(display_short)|uniprotkb:RSK3(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 2(gene name synonym)|uniprotkb:MAPKAPK1C(gene name synonym)|uniprotkb:Ribosomal S6 kinase 3(gene name synonym)|uniprotkb:pp90RSK3(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1c(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_001006933.2|refseq:NP_001305865.1|refseq:NP_001305866.1|refseq:NP_001305867.1|refseq:NP_066958.2|dip:DIP-295N|ensembl:ENSG00000071242(gene)|ensembl:ENST00000265678(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001556"(oocyte maturation)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0060047"(heart contraction)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0072687"(meiotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041906|interpro:IPR042766|mint:Q15349|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:990LeSQ83sti7xG5qGEoFLDkubs9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q15014 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-399257|uniprotkb:B3KP92|uniprotkb:Q567V0|uniprotkb:Q8J026|uniprotkb:D3DXA5|ensembl:ENSP00000353643|ensembl:ENSP00000391969|ensembl:ENSP00000410532|ensembl:ENSP00000415476 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:mo4l2_human(display_long)|uniprotkb:MORF4L2(gene name)|psi-mi:MORF4L2(display_short)|uniprotkb:KIAA0026(gene name synonym)|uniprotkb:MRGX(gene name synonym)|uniprotkb:MORF-related gene X protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRGX(gene name synonym)|uniprotkb:Protein MSL3-2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 refseq:NP_001135894.1|refseq:NP_001135895.1|refseq:NP_001135896.1|refseq:NP_001135897.1|refseq:NP_001135898.1|refseq:NP_001135899.1|refseq:NP_001135900.1|refseq:NP_001135901.1|refseq:NP_001135902.1|refseq:NP_001135903.1|refseq:NP_001135904.1|refseq:NP_036418.1|refseq:NP_001135890.1|refseq:NP_001135891.1|refseq:NP_001135892.1|refseq:NP_001135893.1|ensembl:ENSG00000123562(gene)|ensembl:ENST00000360458(transcript)|ensembl:ENST00000433176(transcript)|ensembl:ENST00000441076(transcript)|ensembl:ENST00000451301(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR008676(MRG)|interpro:IPR026541|interpro:IPR038012|interpro:IPR038217|mint:Q15014|reactome:R-HSA-3214847 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:7SlnJWNVhfdzirTHBEseWbJQjyU9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:P51812 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-1046616|ensembl:ENSP00000368884|uniprotkb:Q4VAP3|uniprotkb:Q59H26|uniprotkb:Q5JPK8|uniprotkb:Q7Z3Z7|uniprotkb:B2R9V4 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:ks6a3_human(display_long)|uniprotkb:Insulin-stimulated protein kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:MAPKAPK1B(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:RPS6KA3(gene name)|psi-mi:RPS6KA3(display_short)|uniprotkb:ISPK1(gene name synonym)|uniprotkb:RSK2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045202"(synapse)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|ensembl:ENSG00000177189(gene)|ensembl:ENST00000379565(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_004577.1|interpro:IPR041905|interpro:IPR041906|mint:P51812|rcsb pdb:4D9T|rcsb pdb:4D9U|rcsb pdb:4JG6|rcsb pdb:4JG7|rcsb pdb:4JG8|rcsb pdb:4NUS|rcsb pdb:4NW5|rcsb pdb:4NW6|rcsb pdb:5D9K|rcsb pdb:5D9L|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|dip:DIP-38247N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:zkX8NPvSEjVEap7TxboH2SKy9zg9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77UV9 uniprotkb:Q15418 intact:EBI-2608731|uniprotkb:Q2HR88 intact:EBI-963034|uniprotkb:A6NGG4|intact:EBI-1383804|uniprotkb:A8K9K7|uniprotkb:B7Z5J0|ensembl:ENSP00000363283|ensembl:ENSP00000486881|uniprotkb:Q5SVM5|uniprotkb:Q5SVM8|uniprotkb:Q5SVM9|uniprotkb:Q96C05|uniprotkb:Q9BQK2|uniprotkb:B2RDY8|uniprotkb:E9PRI4 psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:ks6a1_human(display_long)|uniprotkb:RPS6KA1(gene name)|psi-mi:RPS6KA1(display_short)|uniprotkb:RSK1(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:MAPKAPK1A(gene name synonym)|uniprotkb:Ribosomal S6 kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1a(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063514|imex:IM-26114-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129397.1 ensembl:ENSG00000117676(gene)|ensembl:ENSG00000281877(gene)|ensembl:ENST00000374168(transcript)|ensembl:ENST00000629832(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0106311"|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0043066"(negative regulation of apoptotic process)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR041906|mint:Q15418|rcsb pdb:2WNT|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|rcsb pdb:2Z7Q|rcsb pdb:2Z7R|rcsb pdb:2Z7S|rcsb pdb:3RNY|go:"GO:0045202"(synapse)|rcsb pdb:3TEI|go:"GO:0045597"(positive regulation of cell differentiation)|rcsb pdb:4H3P|rcsb pdb:4NIF|rcsb pdb:5CSF|rcsb pdb:5CSI|rcsb pdb:5CSJ|rcsb pdb:5CSN|rcsb pdb:5N7D|rcsb pdb:5N7F|rcsb pdb:5N7G|rcsb pdb:5V61|rcsb pdb:5V62|rcsb pdb:6TWY|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|refseq:NP_001006666.1|refseq:NP_002944.2|refseq:NP_001317370.1|dip:DIP-29987N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/09/18 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rogid:kx+9PwIH4KR0iTxpv6epDKNqHBE9606 rigid:ZpixEf4wy7oUpdrzCxLb89c/VWU false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RG8 uniprotkb:Q9BZF2 intact:EBI-14063539|uniprotkb:Q2HR87 intact:EBI-14063556|ensembl:ENSP00000007414|ensembl:ENSP00000376295|uniprotkb:D3DTT6|uniprotkb:Q6PIV6 psi-mi:q76rg8_hhv8(display_long)|uniprotkb:UNG(gene name synonym)|uniprotkb:ORF46(gene name)|psi-mi:ORF46(display_short)|uniprotkb:HHV8GK18_gp50(orf name) psi-mi:osbl7_human(display_long)|uniprotkb:OSBPL7(gene name)|psi-mi:OSBPL7(display_short)|uniprotkb:ORP7(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063537|imex:IM-26114-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0006284"(base-excision repair)|go:"GO:0042025"(host cell nucleus)|interpro:IPR036895|refseq:YP_001129398.1|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR018085|interpro:IPR005122(Uracil-DNA glycosylase-like) ensembl:ENSG00000006025(gene)|ensembl:ENST00000007414(transcript)|ensembl:ENST00000392507(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-192105|refseq:NP_665741.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A8kYYy0cEc7nT6kQMpt1IpKMqBg37296 rogid:EMGJAcKZzm3M8p0iLkSDtHFcITQ9606 rigid:T+rHs1Hno2h4zB4Bwe72jlEOUas false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RG8 uniprotkb:Q9H4L5 intact:EBI-14063539|uniprotkb:Q2HR87 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q76rg8_hhv8(display_long)|uniprotkb:UNG(gene name synonym)|uniprotkb:ORF46(gene name)|psi-mi:ORF46(display_short)|uniprotkb:HHV8GK18_gp50(orf name) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063537|imex:IM-26114-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0006284"(base-excision repair)|go:"GO:0042025"(host cell nucleus)|interpro:IPR036895|refseq:YP_001129398.1|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR018085|interpro:IPR005122(Uracil-DNA glycosylase-like) refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A8kYYy0cEc7nT6kQMpt1IpKMqBg37296 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 rigid:T+rHs1Hno2h4zB4Bwe72jlEOUas false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RG8 uniprotkb:Q9BZF3 intact:EBI-14063539|uniprotkb:Q2HR87 intact:EBI-2372709|uniprotkb:B4DTW1|uniprotkb:Q4ZG68|uniprotkb:Q53T68|uniprotkb:Q59H61|uniprotkb:Q7Z4Q1|uniprotkb:Q8N9T0|uniprotkb:Q96SR1|uniprotkb:C4AME4|uniprotkb:C4AMC0|uniprotkb:D3DPF6|uniprotkb:D3DPF7|uniprotkb:Q86V84|intact:EBI-28980578|ensembl:ENSP00000190611 psi-mi:q76rg8_hhv8(display_long)|uniprotkb:UNG(gene name synonym)|uniprotkb:ORF46(gene name)|psi-mi:ORF46(display_short)|uniprotkb:HHV8GK18_gp50(orf name) psi-mi:osbl6_human(display_long)|uniprotkb:OSBPL6(gene name)|psi-mi:OSBPL6(display_short)|uniprotkb:ORP6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063537|imex:IM-26114-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0006284"(base-excision repair)|go:"GO:0042025"(host cell nucleus)|interpro:IPR036895|refseq:YP_001129398.1|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR018085|interpro:IPR005122(Uracil-DNA glycosylase-like) refseq:NP_001188409.1|refseq:NP_001188410.1|refseq:NP_001188411.1|refseq:NP_115912.1|refseq:NP_665682.1|ensembl:ENSP00000190611|ensembl:ENST00000315022|ensembl:ENSP00000318723|ensembl:ENST00000357080|ensembl:ENSP00000349591|ensembl:ENST00000359685|ensembl:ENSP00000352713|ensembl:ENST00000392505|ensembl:ENSP00000376293|ensembl:ENST00000409045|ensembl:ENSP00000387248|ensembl:ENST00000409631|ensembl:ENSP00000386885|refseq:XP_016858755.1|refseq:XP_016858756.1|refseq:XP_016858759.1|refseq:XP_016858760.1|ensembl:ENSG00000079156(gene)|ensembl:ENST00000190611(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9BZF3|reactome:R-HSA-192105 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:A8kYYy0cEc7nT6kQMpt1IpKMqBg37296 rogid:fOUP23b3kO1lBSBPNHP6Ghe6i8c9606 rigid:T+rHs1Hno2h4zB4Bwe72jlEOUas false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q04721 intact:EBI-14063590 intact:EBI-2652733|uniprotkb:Q5T3X7|uniprotkb:Q99734|uniprotkb:Q9H240|ensembl:ENSP00000256646 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:notc2_human(display_long)|uniprotkb:NOTCH2(gene name)|psi-mi:NOTCH2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_001186930.1|refseq:NP_077719.2|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0035622"(intrahepatic bile duct development)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR010660(Notch, NOD region)|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|mint:Q04721|rcsb pdb:2OO4|rcsb pdb:5MWB|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-2197563|reactome:R-HSA-2979096|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-9013695|ensembl:ENSG00000134250(gene)|ensembl:ENST00000256646(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035264"(multicellular organism growth) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:aXdQSGMwNJ7K0tA2kc3rRFysbIc9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q6PKC3 intact:EBI-14063590 intact:EBI-749812|uniprotkb:O95887|uniprotkb:Q6PJA6|uniprotkb:Q8N2Q4|uniprotkb:Q96K45|uniprotkb:Q96K53|ensembl:ENSP00000349439 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:txd11_human(display_long)|uniprotkb:EF-hand-binding protein 1(gene name synonym)|uniprotkb:TXNDC11(gene name)|psi-mi:TXNDC11(display_short)|uniprotkb:EFP1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_056998.4|refseq:NP_001290376.1|refseq:NP_001310953.1|refseq:NP_001310954.1|ensembl:ENSG00000153066(gene)|ensembl:ENST00000356957(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:IQd9IIZUolw+gL+g/pwwTZaqtf49606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P30101 intact:EBI-14063590 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P13667 intact:EBI-14063590 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q9BS26 intact:EBI-14063590 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:O94898 intact:EBI-14063590 intact:EBI-2830372|uniprotkb:Q9NSN2|ensembl:ENSP00000355396 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:lrig2_human(display_long)|uniprotkb:LRIG2(gene name)|psi-mi:LRIG2(display_short)|uniprotkb:KIAA0806(gene name synonym)|uniprotkb:LIG2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_001299615.1|ensembl:ENSG00000198799(gene)|ensembl:ENST00000361127(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010640"(regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030426"(growth cone)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0060384"(innervation)|go:"GO:0097708"(intracellular vesicle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036179|refseq:NP_055628.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:Onv6Wv8jh1k2NSzmTGJU1QD3g6Q9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:O60613 intact:EBI-14063590 intact:EBI-1052797|uniprotkb:Q4GZG7|uniprotkb:Q8WU00|uniprotkb:Q9BS64|uniprotkb:Q9GZW0|uniprotkb:Q9NR01|ensembl:ENSP00000328729|uniprotkb:A0A0B4J1S4 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:sep15_human(display_long)|uniprotkb:SELENOF(gene name)|psi-mi:SELENOF(display_short)|uniprotkb:15 kDa selenoprotein(gene name synonym)|uniprotkb:SEP15(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_004252.2|refseq:NP_976086.1|mint:O60613|interpro:IPR039992|ensembl:ENSG00000183291(gene)|ensembl:ENST00000331835(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0051084"('de novo' posttranslational protein folding)|interpro:IPR014912(Sep15/SelM redox)|interpro:IPR036249|interpro:IPR038219 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:O+C59EK6dpYLDbHWrJT10RtGus89606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q8IZ52 intact:EBI-14063590 intact:EBI-372500|uniprotkb:Q6UXD6|uniprotkb:Q7L4G1|uniprotkb:Q9H0F8|uniprotkb:Q9H618|ensembl:ENSP00000243776|uniprotkb:B4DXU0 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:chss2_human(display_long)|uniprotkb:UNQ651/PRO1281(orf name)|uniprotkb:Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II(gene name synonym)|uniprotkb:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II(gene name synonym)|uniprotkb:Chondroitin glucuronyltransferase 2(gene name synonym)|uniprotkb:N-acetylgalactosaminyltransferase 2(gene name synonym)|uniprotkb:Chondroitin-polymerizing factor(gene name synonym)|uniprotkb:CHPF(gene name)|psi-mi:CHPF(display_short)|uniprotkb:CSS2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_001182660.1|refseq:NP_078812.2|ensembl:ENSG00000123989(gene)|ensembl:ENST00000243776(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008376"(acetylgalactosaminyltransferase activity)|go:"GO:0030206"(chondroitin sulfate biosynthetic process)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0047238"(glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity)|go:"GO:0050510"(N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity)|interpro:IPR008428(Chondroitin N-acetylgalactosaminyltransferase)|reactome:R-HSA-2022870|go:"GO:0016021"(integral component of membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:jfN5U87odagTLP2MJVqowoS6TBw9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q99805 intact:EBI-14063590 intact:EBI-2852254|uniprotkb:Q2TAY5|uniprotkb:A8K399|ensembl:ENSP00000365567|ensembl:ENSP00000493515 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:tm9s2_human(display_long)|uniprotkb:TM9SF2(gene name)|psi-mi:TM9SF2(display_short)|uniprotkb:p76(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_004791.1|ensembl:ENSG00000125304(gene)|ensembl:ENST00000376387(transcript)|ensembl:ENST00000642475(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")|mint:Q99805 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:qg5QSnzX8+4H0Nfab7Ci9n9igc09606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P07237 intact:EBI-14063590 intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:O43149 intact:EBI-14063590 intact:EBI-715672|uniprotkb:Q6NXG0|uniprotkb:Q6ZRA1|uniprotkb:Q6ZSF4|uniprotkb:Q9NVB9|uniprotkb:A7MBM5|ensembl:ENSP00000371051 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:zzef1_human(display_long)|uniprotkb:ZZEF1(gene name)|psi-mi:ZZEF1(display_short)|uniprotkb:KIAA0399(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_055928.3|go:"GO:0005509"(calcium ion binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011992(EF-Hand type)|interpro:IPR040099|interpro:IPR041986|interpro:IPR043145|mint:O43149|ensembl:ENST00000381638(transcript)|ensembl:ENSG00000074755(gene) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:LpYXMInET7VBZ/ZLV23wuQksKTA9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q5T447 intact:EBI-14063590 intact:EBI-2691157|uniprotkb:B3KPV7|uniprotkb:B3KRH4|uniprotkb:Q5T448|uniprotkb:Q9H783|ensembl:ENSP00000361245 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:hecd3_human(display_long)|uniprotkb:HECT domain-containing protein 3(gene name synonym)|uniprotkb:HECTD3(gene name)|psi-mi:HECTD3(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase HECTD3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_078878.3|ensembl:ENSG00000126107(gene)|ensembl:ENST00000372172(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000569(HECT)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR035983|interpro:IPR042469|mint:Q5T447|reactome:R-HSA-983168|go:"GO:0019905"(syntaxin binding) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:laodrF8CReKmM4d6n3sHGBmQB6Q9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q9BVX2 intact:EBI-14063590 intact:EBI-2821497|uniprotkb:Q3B761|uniprotkb:B2R998|uniprotkb:B7Z5M4|ensembl:ENSP00000400471|ensembl:ENSP00000446657 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:t106c_human(display_long)|uniprotkb:TMEM106C(gene name)|psi-mi:TMEM106C(display_short)|uniprotkb:EMOC(gene name synonym)|uniprotkb:Endoplasmic reticulum membrane protein overexpressed in cancer(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_001137313.1|refseq:NP_001137314.1|refseq:NP_001137315.1|refseq:NP_076961.1|ensembl:ENSG00000134291(gene)|ensembl:ENST00000429772(transcript)|ensembl:ENST00000552561(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009790(Protein of unknown function DUF1356) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:Jh3A/cCsKw8v/V7iZLBejXJ0hTU9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P06280 intact:EBI-14063590 intact:EBI-2513305|ensembl:ENSP00000218516|uniprotkb:Q6LER7 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:agal_human(display_long)|uniprotkb:GLA(gene name)|psi-mi:GLA(display_short)|uniprotkb:Alpha-D-galactoside galactohydrolase(gene name synonym)|uniprotkb:Alpha-D-galactosidase A(gene name synonym)|uniprotkb:Melibiase(gene name synonym)|uniprotkb:Galactosylgalactosylglucosylceramidase GLA(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 reactome:R-HSA-1660662|reactome:R-HSA-6798695|ensembl:ENSG00000102393(gene)|ensembl:ENST00000218516(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004557"(alpha-galactosidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016936"(galactoside binding)|go:"GO:0017041"(galactosylgalactosylglucosylceramidase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0046477"(glycosylceramide catabolic process)|go:"GO:0046479"(glycosphingolipid catabolic process)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0052692"(raffinose alpha-galactosidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000111(Glycoside hydrolase, clan GH-D)|interpro:IPR002241(Glycoside hydrolase, family 27)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035373|rcsb pdb:1R46|rcsb pdb:1R47|rcsb pdb:3GXN|rcsb pdb:3GXP|rcsb pdb:3GXT|rcsb pdb:3HG2|rcsb pdb:3HG3|rcsb pdb:3HG4|rcsb pdb:3HG5|rcsb pdb:3LX9|rcsb pdb:3LXA|rcsb pdb:3LXB|rcsb pdb:3LXC|rcsb pdb:3S5Y|rcsb pdb:3S5Z|rcsb pdb:3TV8|rcsb pdb:4NXS|rcsb pdb:6IBK|rcsb pdb:6IBM|rcsb pdb:6IBR|rcsb pdb:6IBT|refseq:NP_000160.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:en4+xuRp2k6kcAkvM2Bla9N3+189606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q14517 intact:EBI-14063590 intact:EBI-1171918|ensembl:ENSP00000406229 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:fat1_human(display_long)|uniprotkb:CDHF7(gene name synonym)|uniprotkb:Cadherin-related tumor suppressor homolog(gene name synonym)|uniprotkb:Protein fat homolog(gene name synonym)|uniprotkb:FAT1(gene name)|psi-mi:FAT1(display_short)|uniprotkb:FAT(gene name synonym)|uniprotkb:Cadherin family member 7(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_005236.2|refseq:XP_006714202.1|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR018097|interpro:IPR020894|mint:Q14517|ensembl:ENSG00000083857(gene)|ensembl:ENST00000441802(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003412"(establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016324"(apical plasma membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:RFztJ1K2/XxuyQ5r603/zNsgNVM9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:Q9NYU1 intact:EBI-14063590 intact:EBI-1054215|uniprotkb:Q5JQR8|uniprotkb:Q9UFC4|uniprotkb:Q08AD0|uniprotkb:A6NKL4|uniprotkb:Q8N5K0|ensembl:ENSP00000365938 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:uggg2_human(display_long)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase 2"(gene name synonym)|uniprotkb:UGGT2(gene name)|psi-mi:UGGT2(display_short)|uniprotkb:UGT2(gene name synonym)|uniprotkb:UGCGL2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_064506.3|ensembl:ENSG00000102595(gene)|ensembl:ENST00000376747(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|reactome:R-HSA-901032 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:jEO6Ao5a4/iJg3Y1DeBydzHDYWM9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P98173 intact:EBI-14063590 intact:EBI-3925304|uniprotkb:A6QRH6|uniprotkb:Q5HY76|uniprotkb:Q96H51|uniprotkb:D3DWX4|uniprotkb:B2RBI7|ensembl:ENSP00000352955|ensembl:ENSP00000358657|ensembl:ENSP00000416146|uniprotkb:B4DFI8 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:fam3a_human(display_long)|uniprotkb:FAM3A(gene name)|psi-mi:FAM3A(display_short)|uniprotkb:2-19(gene name synonym)|uniprotkb:2.19(gene name synonym)|uniprotkb:Cytokine-like protein 2-19(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 refseq:NP_001164603.1|refseq:NP_068578.2|ensembl:ENSG00000071889(gene)|ensembl:ENST00000359889(transcript)|ensembl:ENST00000369643(transcript)|ensembl:ENST00000447601(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|interpro:IPR039220|interpro:IPR039221|interpro:IPR039475|interpro:IPR039477|mint:P98173|refseq:NP_001164605.1|refseq:NP_001164604.1|refseq:NP_001269240.1|refseq:NP_001269241.1|refseq:XP_005277936.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:tqwJ7CWhr1d5PfqBS3MUQQJJs0w9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D2XQB9 uniprotkb:P05067 intact:EBI-14063590 intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3 psi-mi:d2xqb9_hhv8(display_long)|uniprotkb:ORF47(gene name)|psi-mi:ORF47(display_short)|uniprotkb:gL(gene name synonym) psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063588|imex:IM-26114-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0055036"(virion membrane)|interpro:IPR020175|interpro:IPR034708|interpro:IPR038313 go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2018/04/06 rogid:8G50wgts4te8+HpIikAe0t6T8F837296 rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606 rigid:lhzceDsoWOVcfmvs/lEmpY2QqsA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX0 uniprotkb:Q8NB46 intact:EBI-14063944 intact:EBI-1996119|uniprotkb:B1Q2K2|uniprotkb:A6NE79|ensembl:ENSP00000267116 psi-mi:e5lbx0_hhv8(display_long)|uniprotkb:ORF48(gene name)|psi-mi:ORF48(display_short) psi-mi:anr52_human(display_long)|uniprotkb:ANKRD52(gene name)|psi-mi:ANKRD52(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 52(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063942|imex:IM-26114-157 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008550(Protein of unknown function DUF832, gammaherpesvirus) refseq:NP_775866.2|ensembl:ENSG00000139645(gene)|ensembl:ENST00000267116(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:B7D7IiRKqNxWE1i5K+nCF4mtIPQ37296 rogid:yDxfgyMLVZlGwQW0OSokGlMkmPo9606 rigid:uJq+/21f1RwJ5aqZslFMkxHr5eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX0 uniprotkb:O15084 intact:EBI-14063944 intact:EBI-359567|uniprotkb:Q6ULS0|uniprotkb:Q6ZT57|uniprotkb:B4DES5|uniprotkb:Q1WWL4|uniprotkb:Q29RW6|uniprotkb:Q3B857|ensembl:ENSP00000382379|ensembl:ENSP00000397341 psi-mi:e5lbx0_hhv8(display_long)|uniprotkb:ORF48(gene name)|psi-mi:ORF48(display_short) psi-mi:anr28_human(display_long)|uniprotkb:ANKRD28(gene name)|psi-mi:ANKRD28(display_short)|uniprotkb:KIAA0379(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063942|imex:IM-26114-157 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008550(Protein of unknown function DUF832, gammaherpesvirus) refseq:NP_001182027.1|refseq:NP_001182028.1|refseq:NP_056014.2|refseq:XP_011531842.1|refseq:XP_005265053.1|refseq:XP_016861515.1|refseq:XP_016861516.1|dip:DIP-27583N|ensembl:ENSG00000206560(gene)|ensembl:ENST00000399451(transcript)|ensembl:ENST00000412318(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:O15084|reactome:R-HSA-171319|reactome:R-HSA-204005 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:B7D7IiRKqNxWE1i5K+nCF4mtIPQ37296 rogid:YLJtZR7PWrGejJ8EFI093KRtb2Q9606 rigid:uJq+/21f1RwJ5aqZslFMkxHr5eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX0 uniprotkb:Q8N8A2 intact:EBI-14063944 intact:EBI-1245329|uniprotkb:Q6P480|uniprotkb:Q86VL5|uniprotkb:Q8IZ72|uniprotkb:Q9UFA4|uniprotkb:Q53SL9|ensembl:ENSP00000282272 psi-mi:e5lbx0_hhv8(display_long)|uniprotkb:ORF48(gene name)|psi-mi:ORF48(display_short) psi-mi:anr44_human(display_long)|uniprotkb:ANKRD44(gene name)|psi-mi:ANKRD44(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 44(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063942|imex:IM-26114-157 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008550(Protein of unknown function DUF832, gammaherpesvirus) refseq:NP_001182073.1|refseq:NP_710181.2|refseq:XP_005247005.1|ensembl:ENSG00000065413(gene)|ensembl:ENST00000282272(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q8N8A2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:B7D7IiRKqNxWE1i5K+nCF4mtIPQ37296 rogid:Vi+efSZ2F/weEJsGibCJCwhwlXs9606 rigid:uJq+/21f1RwJ5aqZslFMkxHr5eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX0 uniprotkb:O75170 intact:EBI-14063944 intact:EBI-359739|uniprotkb:A6PVG3|uniprotkb:Q7Z5G5|uniprotkb:Q9UGB9|uniprotkb:B7Z7T3|uniprotkb:Q5U5P3|uniprotkb:Q7Z2L2|uniprotkb:Q7Z731|intact:EBI-28971113|ensembl:ENSP00000216061 psi-mi:e5lbx0_hhv8(display_long)|uniprotkb:ORF48(gene name)|psi-mi:ORF48(display_short) psi-mi:pp6r2_human(display_long)|uniprotkb:PP6R2(gene name synonym)|uniprotkb:SAPS domain family member 2(gene name synonym)|uniprotkb:PPP6R2(gene name)|psi-mi:PPP6R2(display_short)|uniprotkb:KIAA0685(gene name synonym)|uniprotkb:SAPS2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063942|imex:IM-26114-157 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008550(Protein of unknown function DUF832, gammaherpesvirus) refseq:NP_001229827.1|refseq:NP_001229828.1|refseq:NP_001229829.1|refseq:NP_055493.2|ensembl:ENSP00000216061|ensembl:ENST00000359139|ensembl:ENSP00000352051|ensembl:ENST00000395741|ensembl:ENSP00000379090|ensembl:ENST00000395744|ensembl:ENSP00000379093|ensembl:ENST00000612753|ensembl:ENSP00000478417|ensembl:ENSG00000100239(gene)|ensembl:ENST00000216061(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_006724497.1|refseq:XP_016884612.1|refseq:XP_016884613.1|refseq:XP_016884617.1|refseq:XP_016884620.1|refseq:XP_016884621.1|dip:DIP-27539N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:B7D7IiRKqNxWE1i5K+nCF4mtIPQ37296 rogid:DfPIffAldPgUOqg8CaheKSLnQ2E9606 rigid:uJq+/21f1RwJ5aqZslFMkxHr5eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX0 uniprotkb:Q9UPN7 intact:EBI-14063944 intact:EBI-359745|uniprotkb:Q2M2H3|uniprotkb:Q504V2|uniprotkb:Q6NVJ6|uniprotkb:Q9BU97|intact:EBI-28973105|ensembl:ENSP00000414202|ensembl:ENSP00000467521 psi-mi:e5lbx0_hhv8(display_long)|uniprotkb:ORF48(gene name)|psi-mi:ORF48(display_short) psi-mi:pp6r1_human(display_long)|uniprotkb:PPP6R1(gene name)|psi-mi:PPP6R1(display_short)|uniprotkb:KIAA1115(gene name synonym)|uniprotkb:PP6R1(gene name synonym)|uniprotkb:SAPS domain family member 1(gene name synonym)|uniprotkb:SAPS1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063942|imex:IM-26114-157 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008550(Protein of unknown function DUF832, gammaherpesvirus) refseq:NP_055746.3|ensembl:ENSP00000414202|ensembl:ENSP00000467521|ensembl:ENSG00000105063(gene)|ensembl:ENST00000412770(transcript)|ensembl:ENST00000587283(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q9UPN7|reactome:R-HSA-204005|dip:DIP-27589N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:B7D7IiRKqNxWE1i5K+nCF4mtIPQ37296 rogid:Nab2lMgz1rQizyvjdbMrJUMNB+I9606 rigid:uJq+/21f1RwJ5aqZslFMkxHr5eA false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:Q9C0C2 intact:EBI-9645848 intact:EBI-2104458|uniprotkb:Q6PJ35|uniprotkb:Q6ZV74|uniprotkb:A7E2F8|intact:EBI-28975617|ensembl:ENSP00000350990|ensembl:ENSP00000437271 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:tb182_human(display_long)|uniprotkb:TNKS1BP1(gene name)|psi-mi:TNKS1BP1(display_short)|uniprotkb:KIAA1741(gene name synonym)|uniprotkb:TAB182(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) refseq:XP_006718788.1|ensembl:ENSP00000350990|ensembl:ENSP00000437271|refseq:NP_203754.2|ensembl:ENSG00000149115(gene)|ensembl:ENST00000358252(transcript)|ensembl:ENST00000532437(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071532"(ankyrin repeat binding)|interpro:IPR032764|interpro:IPR040006|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:pOIaK7wn7iYvUHbSA0kUZlIgtgw9606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:Q9ULM6 intact:EBI-9645848 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:Q9UIV1 intact:EBI-9645848 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:A5YKK6 intact:EBI-9645848 intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:Q9NZN8 intact:EBI-9645848 intact:EBI-743033|uniprotkb:Q9H3E0|uniprotkb:Q9NSX5|uniprotkb:Q9NWR6|uniprotkb:Q9P028|ensembl:ENSP00000229195|ensembl:ENSP00000412091|ensembl:ENSP00000449260 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:cnot2_human(display_long)|uniprotkb:CCR4-associated factor 2(gene name synonym)|uniprotkb:CNOT2(gene name)|psi-mi:CNOT2(display_short)|uniprotkb:CDC36(gene name synonym)|uniprotkb:NOT2(gene name synonym)|uniprotkb:HSPC131(orf name)|uniprotkb:MSTP046(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) refseq:NP_001186231.1|refseq:NP_001186232.1|refseq:XP_011536701.1|refseq:NP_055330.1|dip:DIP-42656N|reactome:R-HSA-429947|reactome:R-HSA-6804115|rcsb pdb:5FU7|ensembl:ENSG00000111596(gene)|ensembl:ENST00000229195(transcript)|ensembl:ENST00000418359(transcript)|ensembl:ENST00000551043(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0001222"(transcription corepressor binding)|rcsb pdb:5FU6|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007282(NOT2/NOT3/NOT5)|interpro:IPR038635|interpro:IPR040168|mint:Q9NZN8|rcsb pdb:4C0D|rcsb pdb:4C0F - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:EuftUgW57O3LzzkQmgktP/V+eQk9606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:E5LBX2 uniprotkb:O75175 intact:EBI-9645848 intact:EBI-743073|ensembl:ENSP00000221232|ensembl:ENSP00000351159|ensembl:ENSP00000478280|ensembl:ENSP00000478956|ensembl:ENSP00000479987|ensembl:ENSP00000480258|ensembl:ENSP00000480585|ensembl:ENSP00000480697|ensembl:ENSP00000480876|ensembl:ENSP00000480988|ensembl:ENSP00000481681|ensembl:ENSP00000481924|ensembl:ENSP00000483036|ensembl:ENSP00000483431|ensembl:ENSP00000483604|ensembl:ENSP00000483692|ensembl:ENSP00000483882|ensembl:ENSP00000483968|ensembl:ENSP00000484040|ensembl:ENSP00000484794|uniprotkb:Q9NZN7|uniprotkb:Q9UF76|intact:EBI-6504867 psi-mi:e5lbx2_hhv8(display_long)|uniprotkb:ORF49(gene name)|psi-mi:ORF49(display_short) psi-mi:cnot3_human(display_long)|uniprotkb:CCR4-associated factor 3(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 2(gene name synonym)|uniprotkb:CNOT3(gene name)|psi-mi:CNOT3(display_short)|uniprotkb:KIAA0691(gene name synonym)|uniprotkb:NOT3(gene name synonym)|uniprotkb:LENG2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063957|imex:IM-26114-135 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006878(BRRF1-like protein) ensembl:ENSG00000088038(gene)|ensembl:ENSG00000273943(gene)|ensembl:ENSG00000274176(gene)|ensembl:ENSG00000274616(gene)|ensembl:ENSG00000274941(gene)|ensembl:ENSG00000275979(gene)|ensembl:ENSG00000276082(gene)|ensembl:ENSG00000277114(gene)|ensembl:ENSG00000277600(gene)|ensembl:ENSG00000277615(gene)|ensembl:ENST00000221232(transcript)|ensembl:ENST00000358389(transcript)|ensembl:ENST00000610883(transcript)|ensembl:ENST00000611252(transcript)|ensembl:ENST00000612924(transcript)|ensembl:ENST00000613528(transcript)|ensembl:ENST00000613752(transcript)|ensembl:ENST00000614649(transcript)|ensembl:ENST00000615030(transcript)|ensembl:ENST00000616359(transcript)|ensembl:ENST00000616910(transcript)|ensembl:ENST00000617982(transcript)|ensembl:ENST00000618405(transcript)|ensembl:ENST00000619567(transcript)|ensembl:ENST00000619854(transcript)|ensembl:ENST00000620060(transcript)|ensembl:ENST00000620419(transcript)|ensembl:ENST00000620573(transcript)|ensembl:ENST00000620970(transcript)|ensembl:ENST00000622131(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007207(Not CCR4-Not complex component, N-terminal)|interpro:IPR007282(NOT2/NOT3/NOT5)|interpro:IPR012270(CCR4-NOT complex, subunits 3 and 5)|interpro:IPR038635|interpro:IPR040168|mint:O75175|rcsb pdb:4C0D|rcsb pdb:4C0G|rcsb pdb:5FU6|rcsb pdb:5FU7|reactome:R-HSA-429947|reactome:R-HSA-6804115|refseq:NP_055331.1|dip:DIP-40297N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:IYWeI3DXhZ/ve0g6TJDk6LzWngE37296 rogid:Qm4YvclCLIfpgmygrSHtkxn/H9E9606 rigid:E+h7fX1ADYYjWPc4oRV/1FYrgSk false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92608 uniprotkb:Q7Z5N4 intact:EBI-7922461|uniprotkb:Q2HR84|intact:MINT-2824732 intact:EBI-3893074|uniprotkb:Q8TEN9|uniprotkb:Q8TEP5|uniprotkb:Q96N44|ensembl:ENSP00000385899 psi-mi:o92608_hhv8(display_long)|uniprotkb:ORF50(gene name)|psi-mi:ORF50(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:HHV8GK18_gp52(orf name) psi-mi:sdk1_human(display_long)|uniprotkb:SDK1(gene name)|psi-mi:SDK1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063968|imex:IM-26114-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129401.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR004998(Herpesvirus transcription activation factor) refseq:NP_689957.3|ensembl:ENSG00000146555(gene)|ensembl:ENST00000404826(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0060998"(regulation of dendritic spine development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|reactome:R-HSA-373756 - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:VPvw5Q3mn1mbz+z/AxRWDZCew4s37296 rogid:QILdppPy9oXtUmEdKGNHFzOo+zE9606 rigid:HPCk5pJ9vVPjsHVuviBX+cmonM4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O92608 uniprotkb:Q15596 intact:EBI-7922461|uniprotkb:Q2HR84|intact:MINT-2824732 intact:EBI-81236|uniprotkb:Q14CD2|ensembl:ENSP00000399968 psi-mi:o92608_hhv8(display_long)|uniprotkb:ORF50(gene name)|psi-mi:ORF50(display_short)|uniprotkb:KIE-1(gene name synonym)|uniprotkb:HHV8GK18_gp52(orf name) psi-mi:ncoa2_human(display_long)|uniprotkb:NCOA2(gene name)|psi-mi:NCOA2(display_short)|uniprotkb:TIF2(gene name synonym)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:BHLHE75(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 75(gene name synonym)|uniprotkb:SRC2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063968|imex:IM-26114-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129401.1|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR004998(Herpesvirus transcription activation factor) refseq:NP_006531.1|rcsb pdb:1ZDU|rcsb pdb:1ZKY|rcsb pdb:2AO6|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2LDC|rcsb pdb:2P15|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2Q7J|rcsb pdb:2Q7L|rcsb pdb:2YJD|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3A9E|rcsb pdb:3CLD|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E7C|rcsb pdb:3E94|rcsb pdb:3ERD|rcsb pdb:3FUG|rcsb pdb:3GN8|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:3KWY|rcsb pdb:3KYT|rcsb pdb:3L0E|rcsb pdb:3L0J|rcsb pdb:3L0L|rcsb pdb:3O1D|rcsb pdb:3O1E|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3PLZ|rcsb pdb:3Q95|rcsb pdb:3R5M|rcsb pdb:3UP0|rcsb pdb:3UP3|rcsb pdb:4CSJ|rcsb pdb:4DOS|rcsb pdb:4E2J|rcsb pdb:4FHH|rcsb pdb:4FHI|rcsb pdb:4IA1|rcsb pdb:4IA2|rcsb pdb:4IA3|rcsb pdb:4IA7|rcsb pdb:4IQR|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|ensembl:ENSG00000140396(gene)|ensembl:ENST00000452400(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q15596|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1M2Z|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1P93|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1UHL|rcsb pdb:1YOK|rcsb pdb:1ZDT|rcsb pdb:4Q0A|rcsb pdb:4Q13|rcsb pdb:4QE6|rcsb pdb:4QE8|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4PXM|rcsb pdb:4RME|rcsb pdb:4RUO|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:4WG0|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5APH|rcsb pdb:5APJ|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4NIE|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4PLD|rcsb pdb:4PLE|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4IU7|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXP|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EC9|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5G3J|rcsb pdb:5G42|rcsb pdb:5G43|rcsb pdb:5G44|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5U2D|rcsb pdb:5UAN|rcsb pdb:5VB3|rcsb pdb:5VB5|rcsb pdb:5VB6|rcsb pdb:5VB7|rcsb pdb:5G46|rcsb pdb:5G5W|rcsb pdb:5H1E|rcsb pdb:5HYR|rcsb pdb:5I4V|rcsb pdb:5IAW|rcsb pdb:5ICK|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5L11|rcsb pdb:5LGA|rcsb pdb:5LYQ|rcsb pdb:5MK4|rcsb pdb:5G45|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5NI5|rcsb pdb:5NI7|rcsb pdb:5NI8|rcsb pdb:5NIB|rcsb pdb:5Q17|rcsb pdb:5SYZ|rcsb pdb:5T1Z|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:6KNU|rcsb pdb:6KNV|rcsb pdb:6KNW|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6LIT|rcsb pdb:6OQX|rcsb pdb:6OQY|rcsb pdb:6OR1|rcsb pdb:6R7A|rcsb pdb:6R7J|rcsb pdb:6R7K|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6VC2|rcsb pdb:6VIF|rcsb pdb:7A77|rcsb pdb:7A78|rcsb pdb:7A79|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7D42|rcsb pdb:6KKE|rcsb pdb:7JHD|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-1989781|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214847|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5625886|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-193807|rcsb pdb:5VQL|rcsb pdb:5WGQ|rcsb pdb:5WZX|rcsb pdb:5XPL|rcsb pdb:5Y1J|rcsb pdb:5Y49|rcsb pdb:5YP5|rcsb pdb:5YXB|rcsb pdb:5YXD|rcsb pdb:5YXJ|rcsb pdb:5YXL|rcsb pdb:5Z12|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:5VQK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6ESN|rcsb pdb:6KKB|refseq:NP_001308642.1|refseq:NP_001308632.1|refseq:NP_001308636.1|refseq:NP_001308640.1|refseq:NP_001308641.1|dip:DIP-5997N - comment:mint - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:VPvw5Q3mn1mbz+z/AxRWDZCew4s37296 rogid:dZP564B7sZPW/ro5h2CVE2XJJpk9606 rigid:HPCk5pJ9vVPjsHVuviBX+cmonM4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBL8 uniprotkb:O15381 intact:EBI-14063977 intact:EBI-721638|uniprotkb:Q96EM7|uniprotkb:B4DMC4|uniprotkb:B4DP98|ensembl:ENSP00000281701 psi-mi:f5hbl8_hhv8(display_long)|uniprotkb:ORF52(gene name)|psi-mi:ORF52(display_short)|uniprotkb:HHV8GK18_gp56(orf name) psi-mi:nvl_human(display_long)|uniprotkb:NVL(gene name)|psi-mi:NVL(display_short)|uniprotkb:NVL2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063975|imex:IM-26114-159 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129405.1|interpro:IPR008642(Herpesvirus BLRF2) refseq:NP_002524.2|refseq:NP_996671.1|refseq:NP_001230075.1|refseq:NP_001230076.1|ensembl:ENSG00000143748(gene)|ensembl:ENST00000281701(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:1904749"(regulation of protein localization to nucleolus)|go:"GO:1990275"(preribosome binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR031996|interpro:IPR038100|interpro:IPR041569|mint:O15381|rcsb pdb:2X8A|rcsb pdb:6RO1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:oe0RrMoTKc4Pxjax4W6rcJJ8csg37296 rogid:3xAHor7LoQCGSzrRQWhKaEuqd9A9606 rigid:MYBmldrQozAdWVuBLObXFX2+y8o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBL8 uniprotkb:P56537 intact:EBI-14063977 intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429 psi-mi:f5hbl8_hhv8(display_long)|uniprotkb:ORF52(gene name)|psi-mi:ORF52(display_short)|uniprotkb:HHV8GK18_gp56(orf name) psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063975|imex:IM-26114-159 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129405.1|interpro:IPR008642(Herpesvirus BLRF2) refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:oe0RrMoTKc4Pxjax4W6rcJJ8csg37296 rogid:A0pOylQptNBlSiBKiZre7INejF49606 rigid:MYBmldrQozAdWVuBLObXFX2+y8o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBL8 uniprotkb:P83111 intact:EBI-14063977 intact:EBI-2878119|ensembl:ENSP00000261893|uniprotkb:P83096 psi-mi:f5hbl8_hhv8(display_long)|uniprotkb:ORF52(gene name)|psi-mi:ORF52(display_short)|uniprotkb:HHV8GK18_gp56(orf name) psi-mi:lactb_human(display_long)|uniprotkb:LACTB(gene name)|psi-mi:LACTB(display_short)|uniprotkb:MRPL56(gene name synonym)|uniprotkb:UNQ843/PRO1781(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063975|imex:IM-26114-159 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129405.1|interpro:IPR008642(Herpesvirus BLRF2) ensembl:ENSG00000103642(gene)|ensembl:ENST00000261893(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001466(Beta-lactamase)|interpro:IPR012338(Beta-lactamase-type transpeptidase fold)|refseq:NP_116246.2|refseq:NP_741982.1|refseq:NP_001275514.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:oe0RrMoTKc4Pxjax4W6rcJJ8csg37296 rogid:idqlmN9YYs76X8+d8+4LALz5WjM9606 rigid:MYBmldrQozAdWVuBLObXFX2+y8o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBL8 uniprotkb:Q15397 intact:EBI-14063977 intact:EBI-725523|uniprotkb:Q547G7|uniprotkb:Q5SZY9|uniprotkb:Q6IB47|uniprotkb:Q96B27|uniprotkb:Q96L78|uniprotkb:Q96L79|uniprotkb:Q96L80|uniprotkb:A8K804|ensembl:ENSP00000380982 psi-mi:f5hbl8_hhv8(display_long)|uniprotkb:ORF52(gene name)|psi-mi:ORF52(display_short)|uniprotkb:HHV8GK18_gp56(orf name) psi-mi:pum3_human(display_long)|uniprotkb:PUM3(gene name)|psi-mi:PUM3(display_short)|uniprotkb:cPERP-C(gene name synonym)|uniprotkb:HBV X-transactivated gene 5 protein(gene name synonym)|uniprotkb:HBV XAg-transactivated protein 5(gene name synonym)|uniprotkb:KIAA0020(gene name synonym)|uniprotkb:Minor histocompatibility antigen HA-8(gene name synonym)|uniprotkb:PUF-A(gene name synonym)|uniprotkb:XTP5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063975|imex:IM-26114-159 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129405.1|interpro:IPR008642(Herpesvirus BLRF2) refseq:NP_055693.4|ensembl:ENSG00000080608(gene)|ensembl:ENST00000397885(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006417"(regulation of translation)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|interpro:IPR001313(Pumilio RNA-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012959(CPL)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033133|interpro:IPR040059|mint:Q15397|rcsb pdb:4WZR|rcsb pdb:4WZW - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:oe0RrMoTKc4Pxjax4W6rcJJ8csg37296 rogid:CjfVWg+3P3ai0EiHgeH8usbvgxg9606 rigid:MYBmldrQozAdWVuBLObXFX2+y8o false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O95249 uniprotkb:Q76RG2 intact:EBI-3235244|ensembl:ENSP00000225724|uniprotkb:O75392|uniprotkb:J3KST5 intact:EBI-14063992|uniprotkb:Q2HR77 psi-mi:gosr1_human(display_long)|uniprotkb:GOSR1(gene name)|psi-mi:GOSR1(display_short)|uniprotkb:GS28(gene name synonym)|uniprotkb:28 kDa Golgi SNARE protein(gene name synonym)|uniprotkb:28 kDa cis-Golgi SNARE p28(gene name synonym) psi-mi:q76rg2_hhv8(display_long)|uniprotkb:ORF55(gene name)|psi-mi:ORF55(display_short)|uniprotkb:HHV8GK18_gp59(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14063990|imex:IM-26114-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108587(gene)|ensembl:ENST00000225724(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048209"(regulation of vesicle targeting, to, from or within Golgi)|interpro:IPR023601|mint:O95249|reactome:R-HSA-6807878|reactome:R-HSA-6811438|refseq:NP_001007025.1|refseq:NP_001007026.1|refseq:NP_004862.1|refseq:XP_005258129.1 refseq:YP_001129408.1|interpro:IPR007619(Herpesvirus U44 protein)|go:"GO:0005737"(cytoplasm)|go:"GO:0019033"(viral tegument)|go:"GO:0044177"(host cell Golgi apparatus) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:zebOuVPnYg5z3XqCa5rMI2IR/jY9606 rogid:bmcjFC0mehUs+1nKnLOSHYV0AtY37296 rigid:sP/uuqsHbFVknXcAA+XvxQTgU0U false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RG1 uniprotkb:P17612 intact:EBI-14064005|uniprotkb:Q2HR76 intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940 psi-mi:q76rg1_hhv8(display_long)|uniprotkb:ORF56(gene name)|psi-mi:ORF56(display_short) psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064003|imex:IM-26114-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR033685|refseq:YP_001129409.1|go:"GO:0003896"(DNA primase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding) refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:Sn4TbABlepyTxg73qLzSHWEfGL437296 rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606 rigid:CnyyuaVG86Ohuaw7KnxPrwBRif4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RG1 uniprotkb:O96008 intact:EBI-14064005|uniprotkb:Q2HR76 intact:EBI-1057581|uniprotkb:Q86VW4|uniprotkb:Q8WY09|uniprotkb:Q8WY10|uniprotkb:Q8WY11|uniprotkb:Q9BR95|uniprotkb:A0A024R0P9|ensembl:ENSP00000252487|ensembl:ENSP00000385184|ensembl:ENSP00000410339 psi-mi:q76rg1_hhv8(display_long)|uniprotkb:ORF56(gene name)|psi-mi:ORF56(display_short) psi-mi:tom40_human(display_long)|uniprotkb:TOMM40(gene name)|psi-mi:TOMM40(display_short)|uniprotkb:PEREC1(gene name synonym)|uniprotkb:TOM40(gene name synonym)|uniprotkb:C19orf1(gene name synonym)|uniprotkb:Translocase of outer membrane 40 kDa subunit homolog(gene name synonym)|uniprotkb:Protein Haymaker(gene name synonym)|uniprotkb:p38.5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064003|imex:IM-26114-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR033685|refseq:YP_001129409.1|go:"GO:0003896"(DNA primase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0046872"(metal ion binding) refseq:NP_001122388.1|refseq:NP_001122389.1|refseq:NP_006105.1|ensembl:ENSG00000130204(gene)|ensembl:ENST00000252487(transcript)|ensembl:ENST00000405636(transcript)|ensembl:ENST00000426677(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006811"(ion transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046930"(pore complex)|interpro:IPR023614|interpro:IPR027246|interpro:IPR037930|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685|go:"GO:0005741"(mitochondrial outer membrane) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:Sn4TbABlepyTxg73qLzSHWEfGL437296 rogid:BBV//Cb2ekmDNGHNrZuAXRgS++Y9606 rigid:CnyyuaVG86Ohuaw7KnxPrwBRif4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:Q8WYA0 intact:EBI-14064023 intact:EBI-11321879|uniprotkb:Q8NB51|uniprotkb:Q9UNY8|uniprotkb:Q2YDY1|uniprotkb:Q9BSV2|ensembl:ENSP00000242591|ensembl:ENSP00000449718 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:ift81_human(display_long)|uniprotkb:IFT81(gene name)|psi-mi:IFT81(display_short)|uniprotkb:CDV1(gene name synonym)|uniprotkb:Carnitine deficiency-associated protein expressed in ventricle 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:XP_016874706.1|refseq:NP_001137251.1|refseq:NP_054774.2|refseq:NP_113661.2|refseq:NP_001334875.1|ensembl:ENSG00000122970(gene)|ensembl:ENST00000242591(transcript)|ensembl:ENST00000552912(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0030992"(intraciliary transport particle B)|go:"GO:0031514"(motile cilium)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0060271"(cilium assembly)|go:"GO:0097542"(ciliary tip)|interpro:IPR029600|interpro:IPR041146|interpro:IPR043016|mint:Q8WYA0|reactome:R-HSA-5620924 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:2+081wYMeK1gK+kuJRx3DFuiaGU9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:O00178 intact:EBI-14064023 intact:EBI-4403245|uniprotkb:Q6IC67|intact:EBI-28983557|ensembl:ENSP00000216044 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:gtpb1_human(display_long)|uniprotkb:GTPBP1(gene name)|psi-mi:GTPBP1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:NP_004277.2|ensembl:ENSP00000216044|ensembl:ENSG00000100226(gene)|ensembl:ENST00000216044(transcript)|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR035531|interpro:IPR039263 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:xgrFwHgoeIjQuqyzXCt0+Y2IQNk9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:Q9C0C9 intact:EBI-14064023 intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:O43709 intact:EBI-14064023 intact:EBI-1044726|uniprotkb:Q96P12|uniprotkb:Q9BQ58|uniprotkb:Q9HBP9|ensembl:ENSP00000265758|uniprotkb:A8K501|uniprotkb:C9K060 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:bud23_human(display_long)|uniprotkb:BUD23(gene name)|psi-mi:BUD23(display_short)|uniprotkb:Bud site selection protein 23 homolog(gene name synonym)|uniprotkb:MERM1(gene name synonym)|uniprotkb:Metastasis-related methyltransferase 1(gene name synonym)|uniprotkb:WBSCR22(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 22 protein(gene name synonym)|uniprotkb:rRNA methyltransferase and ribosome maturation factor(gene name synonym)|uniprotkb:HUSSY-03(orf name)|uniprotkb:PP3381(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:NP_059998.2|ensembl:ENSG00000071462(gene)|ensembl:ENST00000265758(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006325"(chromatin organization)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016435"("rRNA (guanine) methyltransferase activity")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070476"("rRNA (guanine-N7)-methylation")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR022238|interpro:IPR029063|interpro:IPR039769|mint:O43709|rcsb pdb:6G4W|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_001189489.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:OBL2pV3hp8qvbqKzEVAk82pSPdU9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:P25440 intact:EBI-14064023 intact:EBI-2874802|uniprotkb:Q5STC9|uniprotkb:Q6P3U2|uniprotkb:O00699|uniprotkb:B1AZT1|uniprotkb:B0S7P0|uniprotkb:Q969U4|uniprotkb:Q15310|uniprotkb:O00700|uniprotkb:A2AAU0|uniprotkb:Q63HQ9|uniprotkb:Q658Y7|ensembl:ENSP00000363958|ensembl:ENSP00000363964|ensembl:ENSP00000372588|ensembl:ENSP00000382444|ensembl:ENSP00000382445|ensembl:ENSP00000391246|ensembl:ENSP00000399009|ensembl:ENSP00000401791|ensembl:ENSP00000409145|ensembl:ENSP00000449380|ensembl:ENSP00000449609|ensembl:ENSP00000502900 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:brd2_human(display_long)|uniprotkb:BRD2(gene name)|psi-mi:BRD2(display_short)|uniprotkb:KIAA9001(gene name synonym)|uniprotkb:RING3(gene name synonym)|uniprotkb:O27.1.1(gene name synonym)|uniprotkb:Really interesting new gene 3 protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:NP_001278915.1|refseq:NP_001106653.1|refseq:NP_001186384.1|refseq:NP_001186385.1|refseq:NP_005095.1|dip:DIP-60835N|ensembl:ENSG00000204256(gene)|ensembl:ENSG00000215077(gene)|ensembl:ENSG00000234507(gene)|ensembl:ENSG00000234704(gene)|ensembl:ENSG00000235307(gene)|ensembl:ENST00000374825(transcript)|ensembl:ENST00000374831(transcript)|ensembl:ENST00000383108(transcript)|ensembl:ENST00000399528(transcript)|ensembl:ENST00000399529(transcript)|ensembl:ENST00000414731(transcript)|ensembl:ENST00000438194(transcript)|ensembl:ENST00000449085(transcript)|ensembl:ENST00000449118(transcript)|ensembl:ENST00000549126(transcript)|ensembl:ENST00000552587(transcript)|ensembl:ENST00000678250(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0070577"(lysine-acetylated histone binding)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:P25440|rcsb pdb:1X0J|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2DVS|rcsb pdb:2DVV|rcsb pdb:2E3K|rcsb pdb:2G4A|rcsb pdb:2YDW|rcsb pdb:2YEK|rcsb pdb:3AQA|rcsb pdb:3ONI|rcsb pdb:4A9E|rcsb pdb:4A9F|rcsb pdb:4A9H|rcsb pdb:4A9I|rcsb pdb:4A9J|rcsb pdb:4A9M|rcsb pdb:4A9N|rcsb pdb:4A9O|rcsb pdb:4AKN|rcsb pdb:4ALG|rcsb pdb:4ALH|rcsb pdb:4J1P|rcsb pdb:4MR5|rcsb pdb:4QEU|rcsb pdb:4QEV|rcsb pdb:4QEW|rcsb pdb:4UYF|rcsb pdb:4UYG|rcsb pdb:4UYH|rcsb pdb:5BT5|rcsb pdb:5DFB|rcsb pdb:5DFC|rcsb pdb:5DFD|rcsb pdb:5DW1|rcsb pdb:5EK9|rcsb pdb:5HEL|rcsb pdb:5HEM|rcsb pdb:5HEN|rcsb pdb:5HFQ|rcsb pdb:5IBN|rcsb pdb:5IG6|rcsb pdb:5N2L|rcsb pdb:5O38|rcsb pdb:5O39|rcsb pdb:5O3A|rcsb pdb:5O3B|rcsb pdb:5O3C|rcsb pdb:5O3D|rcsb pdb:5O3E|rcsb pdb:5O3F|rcsb pdb:5O3G|rcsb pdb:5O3H|rcsb pdb:5O3I|rcsb pdb:5U5S|rcsb pdb:5U6V|rcsb pdb:5UEW|rcsb pdb:5XHE|rcsb pdb:5XHK|rcsb pdb:6CUI|rcsb pdb:6DB0|rcsb pdb:6DBC|rcsb pdb:6DDI|rcsb pdb:6DDJ|rcsb pdb:4MR6|rcsb pdb:6E6J|rcsb pdb:6FFE|rcsb pdb:6FFF|rcsb pdb:6FFG|rcsb pdb:6I80|rcsb pdb:6I81|rcsb pdb:6JKE|rcsb pdb:6K05|rcsb pdb:6MO7|rcsb pdb:6MO8|rcsb pdb:6MO9|rcsb pdb:6MOA|rcsb pdb:6ONY|rcsb pdb:6SWO|rcsb pdb:6SWP|rcsb pdb:6TQ1|rcsb pdb:6TQ2|rcsb pdb:6U61|rcsb pdb:6U71|rcsb pdb:6U8H|rcsb pdb:6ULQ|rcsb pdb:6ULT|rcsb pdb:6VIY|rcsb pdb:6YTM|rcsb pdb:6Z7F|rcsb pdb:6Z8P|rcsb pdb:6ZB0|rcsb pdb:6ZB1|rcsb pdb:6ZB2|rcsb pdb:7JX7|rcsb pdb:7L6D|rcsb pdb:7NQ5|rcsb pdb:7NQ7|rcsb pdb:7NQ8|rcsb pdb:7NQ9|rcsb pdb:7NQI|rcsb pdb:7NQJ|reactome:R-HSA-8951936|rcsb pdb:6K04 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:Q3ELpiTZgboufxPDV/bypJZC2oY9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZS0 uniprotkb:O60885 intact:EBI-14064023 intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8 psi-mi:d0uzs0_hhv8(display_long)|uniprotkb:ORF57(gene name)|psi-mi:ORF57(display_short)|uniprotkb:HHV8GK18_gp61(orf name) psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064021|imex:IM-26114-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129410.1|interpro:IPR008648(Herpesvirus transcriptional regulator)|go:"GO:0006355"(regulation of transcription, DNA-templated) refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:uz5jAyUcPT0g+MBLU1hpzevlfJ837296 rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606 rigid:pB5eGMnIki2CivlOsqwHz8i57G4 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG4 uniprotkb:Q8N0U8 intact:EBI-14064041|uniprotkb:Q2HR70 intact:EBI-11337915|uniprotkb:E7ETM5|uniprotkb:Q6AHW9|uniprotkb:B4E222|uniprotkb:Q6TEK6|ensembl:ENSP00000353998|ensembl:ENSP00000497394 psi-mi:q77zg4_hhv8(display_long)|uniprotkb:ORF58(gene name)|psi-mi:ORF58(display_short)|uniprotkb:HHV8GK18_gp68(orf name) psi-mi:vkorl_human(display_long)|uniprotkb:VKORC1L1(gene name)|psi-mi:VKORC1L1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064039|imex:IM-26114-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129415.1|interpro:IPR006727(Herpesvirus BMRF2 protein)|go:"GO:0016021"(integral component of membrane) refseq:NP_001271271.1|refseq:NP_775788.2|ensembl:ENSG00000196715(gene)|ensembl:ENST00000360768(transcript)|ensembl:ENST00000648179(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017187"(peptidyl-glutamic acid carboxylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042373"(vitamin K metabolic process)|go:"GO:0047057"("vitamin-K-epoxide reductase (warfarin-sensitive) activity")|go:"GO:0048038"(quinone binding)|interpro:IPR012932(Vitamin K epoxide reductase)|interpro:IPR038354|interpro:IPR042406|mint:Q8N0U8|reactome:R-HSA-6806664 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:TD76bZNoFxsPWVUgpR/np2BeySY37296 rogid:0gdoyZTMoqEjTsPOfeUNSlH4M7k9606 rigid:dfsr5PBCA4GDbRWcrThKZam7je0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG4 uniprotkb:Q9P0P0 intact:EBI-14064041|uniprotkb:Q2HR70 intact:EBI-2129136|uniprotkb:Q53H81|ensembl:ENSP00000306906 psi-mi:q77zg4_hhv8(display_long)|uniprotkb:ORF58(gene name)|psi-mi:ORF58(display_short)|uniprotkb:HHV8GK18_gp68(orf name) psi-mi:rn181_human(display_long)|uniprotkb:RNF181(gene name)|psi-mi:RNF181(display_short)|uniprotkb:RING finger protein 181(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF181(gene name synonym)|uniprotkb:HSPC238(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064039|imex:IM-26114-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129415.1|interpro:IPR006727(Herpesvirus BMRF2 protein)|go:"GO:0016021"(integral component of membrane) refseq:NP_057578.1|ensembl:ENSG00000168894(gene)|ensembl:ENST00000306368(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8866654 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:TD76bZNoFxsPWVUgpR/np2BeySY37296 rogid:x4PKFJLxySPGeIOgwWMI2t1bVaU9606 rigid:dfsr5PBCA4GDbRWcrThKZam7je0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG4 uniprotkb:Q9Y6Y8 intact:EBI-14064041|uniprotkb:Q2HR70 intact:EBI-1767971|uniprotkb:Q8IXH5|uniprotkb:Q9BUK5|uniprotkb:D3DRD2|ensembl:ENSP00000358071 psi-mi:q77zg4_hhv8(display_long)|uniprotkb:ORF58(gene name)|psi-mi:ORF58(display_short)|uniprotkb:HHV8GK18_gp68(orf name) psi-mi:s23ip_human(display_long)|uniprotkb:SEC23IP(gene name)|psi-mi:SEC23IP(display_short)|uniprotkb:MSTP053(orf name)|uniprotkb:p125(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064039|imex:IM-26114-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129415.1|interpro:IPR006727(Herpesvirus BMRF2 protein)|go:"GO:0016021"(integral component of membrane) refseq:NP_009121.1|ensembl:ENSG00000107651(gene)|ensembl:ENST00000369075(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004620"(phospholipase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004177(DDHD)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR037603|reactome:R-HSA-204005 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:TD76bZNoFxsPWVUgpR/np2BeySY37296 rogid:KXVMjjUp55QjYFNi22H0exqJyEs9606 rigid:dfsr5PBCA4GDbRWcrThKZam7je0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG4 uniprotkb:Q15042 intact:EBI-14064041|uniprotkb:Q2HR70 intact:EBI-1053078|uniprotkb:Q659F5|uniprotkb:Q8TBB4|uniprotkb:C9J837|ensembl:ENSP00000264158|uniprotkb:A6H8Z3 psi-mi:q77zg4_hhv8(display_long)|uniprotkb:ORF58(gene name)|psi-mi:ORF58(display_short)|uniprotkb:HHV8GK18_gp68(orf name) psi-mi:rb3gp_human(display_long)|uniprotkb:RAB3 GTPase-activating protein 130 kDa subunit(gene name synonym)|uniprotkb:Rab3-GAP p130(gene name synonym)|uniprotkb:RAB3GAP1(gene name)|psi-mi:RAB3GAP1(display_short)|uniprotkb:KIAA0066(gene name synonym)|uniprotkb:RAB3GAP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064039|imex:IM-26114-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129415.1|interpro:IPR006727(Herpesvirus BMRF2 protein)|go:"GO:0016021"(integral component of membrane) refseq:NP_036365.1|ensembl:ENSG00000115839(gene)|ensembl:ENST00000264158(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0007420"(brain development)|go:"GO:0021854"(hypothalamus development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097051"(establishment of protein localization to endoplasmic reticulum membrane)|go:"GO:0098794"(postsynapse)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR026147|reactome:R-HSA-6811436|reactome:R-HSA-8876198|refseq:NP_001165906.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:TD76bZNoFxsPWVUgpR/np2BeySY37296 rogid:JCtnJX01timbIenQexwG84yBu2I9606 rigid:dfsr5PBCA4GDbRWcrThKZam7je0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG4 uniprotkb:P43378 intact:EBI-14064041|uniprotkb:Q2HR70 intact:EBI-742898|ensembl:ENSP00000482732|uniprotkb:Q53XR9 psi-mi:q77zg4_hhv8(display_long)|uniprotkb:ORF58(gene name)|psi-mi:ORF58(display_short)|uniprotkb:HHV8GK18_gp68(orf name) psi-mi:ptn9_human(display_long)|uniprotkb:Protein-tyrosine phosphatase MEG2(gene name synonym)|uniprotkb:PTPN9(gene name)|psi-mi:PTPN9(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064039|imex:IM-26114-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129415.1|interpro:IPR006727(Herpesvirus BMRF2 protein)|go:"GO:0016021"(integral component of membrane) refseq:NP_002824.1|ensembl:ENSG00000169410(gene)|ensembl:ENST00000618819(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011074(Phosphatidylinositol transfer protein-like, N-terminal)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036273|interpro:IPR036865|mint:P43378|rcsb pdb:2PA5|rcsb pdb:4GE2|rcsb pdb:4GE5|rcsb pdb:4GE6|rcsb pdb:4ICZ|rcsb pdb:6KZQ|rcsb pdb:6L03|reactome:R-HSA-9008059 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:TD76bZNoFxsPWVUgpR/np2BeySY37296 rogid:n4CPv2fRWsJLno+eBY4Kj8K0ylo9606 rigid:dfsr5PBCA4GDbRWcrThKZam7je0 false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG5 uniprotkb:Q9UPP1 intact:EBI-14064059|uniprotkb:Q2HR69 intact:EBI-1560800|uniprotkb:Q5H9U5|uniprotkb:Q5VUJ4|uniprotkb:Q7Z6D4|uniprotkb:Q9HAH2|uniprotkb:Q5JPS0|uniprotkb:Q5JPS2|uniprotkb:Q5JPS3|uniprotkb:B7Z911|uniprotkb:Q5JPR9|uniprotkb:B3KMV4|ensembl:ENSP00000350676 psi-mi:q77zg5_hhv8(display_long)|uniprotkb:ORF59(gene name)|psi-mi:ORF59(display_short)|uniprotkb:HHV8GK18_gp70(orf name) psi-mi:phf8_human(display_long)|uniprotkb:PHF8(gene name)|psi-mi:PHF8(display_short)|uniprotkb:KIAA1111(gene name synonym)|uniprotkb:ZNF422(gene name synonym)|uniprotkb:PHD finger protein 8(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(36) demethylase PHF8"(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase PHF8"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064057|imex:IM-26114-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129416.1|rcsb pdb:3HSL|rcsb pdb:3I2M|interpro:IPR007013(DNA replication accessory factor, herpesviridae) refseq:NP_001171825.1|refseq:NP_001171826.1|refseq:NP_055922.1|refseq:XP_016884851.1|dip:DIP-38913N|ensembl:ENSG00000172943(gene)|ensembl:ENST00000357988(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035574"(histone H4-K20 demethylation)|go:"GO:0035575"(histone H4-methyl-lysine-20 demethylase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0061188"(negative regulation of ribosomal DNA heterochromatin assembly)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR041070|rcsb pdb:2WWU|rcsb pdb:3K3N|rcsb pdb:3K3O|rcsb pdb:3KV4|rcsb pdb:4DO0|rcsb pdb:7CMZ|reactome:R-HSA-2299718|reactome:R-HSA-3214842 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:a/qfxPShsWgzHfvOqPfs5E0uPmY37296 rogid:/HpV11qoBcuj2YCa2dQWuo9moCk9606 rigid:E6ptWXMtPR0BJGxqAlNOI4ttSKc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG5 uniprotkb:Q8IYB3 intact:EBI-14064059|uniprotkb:Q2HR69 intact:EBI-1055880|uniprotkb:O60585|uniprotkb:Q5VVN4|ensembl:ENSP00000326261 psi-mi:q77zg5_hhv8(display_long)|uniprotkb:ORF59(gene name)|psi-mi:ORF59(display_short)|uniprotkb:HHV8GK18_gp70(orf name) psi-mi:srrm1_human(display_long)|uniprotkb:SRRM1(gene name)|psi-mi:SRRM1(display_short)|uniprotkb:SRM160(gene name synonym)|uniprotkb:Ser/Arg-related nuclear matrix protein(gene name synonym)|uniprotkb:SR-related nuclear matrix protein of 160 kDa(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064057|imex:IM-26114-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129416.1|rcsb pdb:3HSL|rcsb pdb:3I2M|interpro:IPR007013(DNA replication accessory factor, herpesviridae) refseq:NP_001290377.1|refseq:NP_001290378.1|refseq:NP_005830.2|ensembl:ENSG00000133226(gene)|ensembl:ENST00000323848(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR036483|mint:Q8IYB3|rcsb pdb:1MP1|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013422|reactome:R-HSA-9013418 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:a/qfxPShsWgzHfvOqPfs5E0uPmY37296 rogid:x9vhX2HWCy5mm29U2xVXxj1GJw09606 rigid:E6ptWXMtPR0BJGxqAlNOI4ttSKc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG5 uniprotkb:O75683 intact:EBI-14064059|uniprotkb:Q2HR69 intact:EBI-2691252|uniprotkb:Q9UK24|uniprotkb:Q9BTZ5|uniprotkb:Q5T8U1|uniprotkb:Q9BRK9|ensembl:ENSP00000361092|ensembl:ENSP00000485909 psi-mi:q77zg5_hhv8(display_long)|uniprotkb:ORF59(gene name)|psi-mi:ORF59(display_short)|uniprotkb:HHV8GK18_gp70(orf name) psi-mi:surf6_human(display_long)|uniprotkb:SURF-6(gene name synonym)|uniprotkb:SURF6(gene name)|psi-mi:SURF6(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064057|imex:IM-26114-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129416.1|rcsb pdb:3HSL|rcsb pdb:3I2M|interpro:IPR007013(DNA replication accessory factor, herpesviridae) refseq:NP_006744.2|refseq:NP_001265871.1|ensembl:ENSG00000148296(gene)|ensembl:ENSG00000281309(gene)|ensembl:ENST00000372022(transcript)|ensembl:ENST00000629980(transcript)|go:"GO:0001652"(granular component)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR007019(Surfeit locus 6)|interpro:IPR029190 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:a/qfxPShsWgzHfvOqPfs5E0uPmY37296 rogid:1Yzf0+p31xuzJXSoaiz9THfjF0c9606 rigid:E6ptWXMtPR0BJGxqAlNOI4ttSKc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q77ZG5 uniprotkb:P20226 intact:EBI-14064059|uniprotkb:Q2HR69 intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869 psi-mi:q77zg5_hhv8(display_long)|uniprotkb:ORF59(gene name)|psi-mi:ORF59(display_short)|uniprotkb:HHV8GK18_gp70(orf name) psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064057|imex:IM-26114-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129416.1|rcsb pdb:3HSL|rcsb pdb:3I2M|interpro:IPR007013(DNA replication accessory factor, herpesviridae) refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:a/qfxPShsWgzHfvOqPfs5E0uPmY37296 rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606 rigid:E6ptWXMtPR0BJGxqAlNOI4ttSKc false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q08AD1 uniprotkb:O40913 intact:EBI-1051869|uniprotkb:B1APG6|uniprotkb:Q08AD2|uniprotkb:Q6PGN8|uniprotkb:Q96FB3|uniprotkb:Q9UG20|uniprotkb:Q9UPS4|ensembl:ENSP00000236925 intact:EBI-14064077 psi-mi:camp2_human(display_long)|uniprotkb:KIAA1078(gene name synonym)|uniprotkb:CAMSAP2(gene name)|psi-mi:CAMSAP2(display_short)|uniprotkb:CAMSAP1L1(gene name synonym)|uniprotkb:Calmodulin-regulated spectrin-associated protein 1-like protein 1(gene name synonym) psi-mi:o40913_hhv8(display_long)|uniprotkb:ORF6(gene name)|psi-mi:ORF6(display_short)|uniprotkb:DBP(gene name synonym)|uniprotkb:HHV8GK18_gp03(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064075|imex:IM-26114-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_982284.1|refseq:NP_001284636.1|refseq:NP_001284637.1|ensembl:ENSP00000236925|ensembl:ENST00000358823|ensembl:ENSP00000351684|ensembl:ENST00000413307|ensembl:ENSP00000416800|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011033(PRC-barrel-like)|interpro:IPR014797(Protein of unknown function DUF1781)|interpro:IPR022613|interpro:IPR031372|interpro:IPR032940|interpro:IPR036872|interpro:IPR038209|go:"GO:1990752"(microtubule end)|ensembl:ENSG00000118200(gene)|ensembl:ENST00000236925(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0030507"(spectrin binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0033043"(regulation of organelle organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0061564"(axon development)|go:"GO:1903358"(regulation of Golgi organization) interpro:IPR000635(Viral ssDNA-binding protein)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR035989|interpro:IPR043031 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:dYxSv8D6Jw1iRvPJ0nsmLdiEcz09606 rogid:8RnSy9tvLxRSR0OD3S0kPEQ2N3M37296 rigid:Xst0ebgCvN10I5muydVN0NMnjNI false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF7 uniprotkb:Q96PD5 intact:EBI-14064093|uniprotkb:Q2HR68 intact:EBI-2827706|uniprotkb:Q96N74|uniprotkb:A8K8C7|uniprotkb:Q9UC60|uniprotkb:Q68CK1|uniprotkb:B2RMZ2|ensembl:ENSP00000345968|uniprotkb:A8K050|uniprotkb:B7ZM33 psi-mi:q76rf7_hhv8(display_long)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:ORF60(gene name)|psi-mi:ORF60(display_short)|uniprotkb:RIR2(gene name synonym)|uniprotkb:HHV8GK18_gp67(orf name) psi-mi:pgrp2_human(display_long)|uniprotkb:PGLYRP2(gene name)|psi-mi:PGLYRP2(display_short)|uniprotkb:PGLYRPL(gene name synonym)|uniprotkb:PGRPL(gene name synonym)|uniprotkb:Peptidoglycan recognition protein 2(gene name synonym)|uniprotkb:Peptidoglycan recognition protein long(gene name synonym)|uniprotkb:UNQ3103/PRO10102(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064091|imex:IM-26114-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129417.1|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR034715|interpro:IPR033909|interpro:IPR030475|interpro:IPR000358(Ribonucleotide reductase)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0006260"(DNA replication)|go:"GO:0009186"(deoxyribonucleoside diphosphate metabolic process)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR012348(Ribonucleotide reductase-related) refseq:NP_443122.3|ensembl:ENSG00000161031(gene)|ensembl:ENST00000340880(transcript)|go:"GO:0001519"(peptide amidation)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008745"(N-acetylmuramoyl-L-alanine amidase activity)|go:"GO:0009253"(peptidoglycan catabolic process)|go:"GO:0016019"(peptidoglycan immune receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032827"(negative regulation of natural killer cell differentiation involved in immune response)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002502(N-acetylmuramoyl-L-alanine amidase, family 2)|interpro:IPR006619(Peptidoglycan recognition protein, metazoa/bacteria)|interpro:IPR015510(Peptidoglycan recognition protein)|interpro:IPR036505|reactome:R-HSA-6803157|go:"GO:0016045"(detection of bacterium)|refseq:XP_006722696.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:CV7h88+TzgQcEPfDCY1Vjrf11s837296 rogid:ix6fnj4wGJ9MHK9UHK9HI5Axn9E9606 rigid:tOFOYFgy/QxGyladTW/4zr6hn2Q false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF7 uniprotkb:Q9H4P4 intact:EBI-14064093|uniprotkb:Q2HR68 intact:EBI-2130266|uniprotkb:B2RBT8|uniprotkb:O75598|intact:EBI-2563208|intact:EBI-11576203|uniprotkb:A6NFW0|ensembl:ENSP00000342755|ensembl:ENSP00000447303|ensembl:ENSP00000484671 psi-mi:q76rf7_hhv8(display_long)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:ORF60(gene name)|psi-mi:ORF60(display_short)|uniprotkb:RIR2(gene name synonym)|uniprotkb:HHV8GK18_gp67(orf name) psi-mi:rnf41_human(display_long)|uniprotkb:RNF41(gene name)|psi-mi:RNF41(display_short)|uniprotkb:FLRF(gene name synonym)|uniprotkb:NRDP1(gene name synonym)|uniprotkb:RING finger protein 41(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NRDP1(gene name synonym)|uniprotkb:SBBI03(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064091|imex:IM-26114-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129417.1|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR034715|interpro:IPR033909|interpro:IPR030475|interpro:IPR000358(Ribonucleotide reductase)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0006260"(DNA replication)|go:"GO:0009186"(deoxyribonucleoside diphosphate metabolic process)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR012348(Ribonucleotide reductase-related) refseq:XP_011536036.1|refseq:XP_011536037.1|refseq:NP_001229755.1|refseq:NP_005776.1|refseq:NP_919340.1|refseq:NP_919339.1|refseq:XP_005268618.1|ensembl:ENSG00000181852(gene)|ensembl:ENST00000345093(transcript)|ensembl:ENST00000552656(transcript)|ensembl:ENST00000615206(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015036(USP8 interacting)|interpro:IPR017907|interpro:IPR037255|rcsb pdb:2FZP|rcsb pdb:2GWF|reactome:R-HSA-1358803|reactome:R-HSA-983168 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:CV7h88+TzgQcEPfDCY1Vjrf11s837296 rogid:jthVZwxUECSdqeJ2jZQ5UL28kDY9606 rigid:tOFOYFgy/QxGyladTW/4zr6hn2Q false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF6 uniprotkb:Q8NDF8 intact:EBI-2608615|uniprotkb:Q2HR66 intact:EBI-2803971|uniprotkb:Q9NW67|uniprotkb:Q9Y6C0|uniprotkb:B4DV38 psi-mi:q76rf6_hhv8(display_long)|uniprotkb:ORF62(gene name)|psi-mi:ORF62(display_short)|uniprotkb:TRX1(gene name synonym)|uniprotkb:HHV8GK18_gp69(orf name) psi-mi:papd5_human(display_long)|uniprotkb:"Non-canonical poly(A) RNA polymerase PAPD5"(gene name synonym)|uniprotkb:TUT3(gene name synonym)|uniprotkb:Terminal guanylyltransferase(gene name synonym)|uniprotkb:TENT4B(gene name)|psi-mi:TENT4B(display_short)|uniprotkb:GLD4(gene name synonym)|uniprotkb:PAP-associated domain-containing protein 5(gene name synonym)|uniprotkb:PAPD5(gene name synonym)|uniprotkb:TRF4-2(gene name synonym)|uniprotkb:Terminal uridylyltransferase 3(gene name synonym)|uniprotkb:Topoisomerase-related function protein 4-2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064117|imex:IM-26114-137 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129419.1|interpro:IPR004999(Herpesvirus capsid shell protein VP19C)|go:"GO:0019028"(viral capsid)|go:"GO:0019069"(viral capsid assembly)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003677"(DNA binding)|rcsb pdb:6B43 refseq:NP_001035375.2|refseq:NP_001035374.2|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0031499"(TRAMP complex)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0033500"(carbohydrate homeostasis)|go:"GO:0043629"(ncRNA polyadenylation)|go:"GO:0043630"(ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070568"(guanylyltransferase activity)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071050"("sno(s)RNA polyadenylation")|go:"GO:0071076"(RNA 3' uridylation)|go:"GO:1905870"(positive regulation of 3'-UTR-mediated mRNA stabilization)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR040136|interpro:IPR043519|dip:DIP-59183N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:AUb8Fu9qQ/NtHMbqI7EupSOp12Y37296 rogid:Dy+EsRClygf3oq2i8AdtST3ENS49606 rigid:GsjyCeBzlfKSCvwcwKdi85p2J2w false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF6 uniprotkb:P43246 intact:EBI-2608615|uniprotkb:Q2HR66 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:q76rf6_hhv8(display_long)|uniprotkb:ORF62(gene name)|psi-mi:ORF62(display_short)|uniprotkb:TRX1(gene name synonym)|uniprotkb:HHV8GK18_gp69(orf name) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064117|imex:IM-26114-137 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129419.1|interpro:IPR004999(Herpesvirus capsid shell protein VP19C)|go:"GO:0019028"(viral capsid)|go:"GO:0019069"(viral capsid assembly)|go:"GO:0042025"(host cell nucleus)|go:"GO:0003677"(DNA binding)|rcsb pdb:6B43 refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/19 rogid:AUb8Fu9qQ/NtHMbqI7EupSOp12Y37296 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 rigid:GsjyCeBzlfKSCvwcwKdi85p2J2w false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q5JV73 uniprotkb:Q76RF5 intact:EBI-4401756|uniprotkb:Q96JK8|ensembl:ENSP00000276185 intact:EBI-2608777|uniprotkb:Q2HR65|intact:EBI-2649456 psi-mi:frpd3_human(display_long)|uniprotkb:FRMPD3(gene name)|psi-mi:FRMPD3(display_short)|uniprotkb:KIAA1817(gene name synonym) psi-mi:q76rf5_hhv8(display_long)|uniprotkb:ORF63(gene name)|psi-mi:ORF63(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064124|imex:IM-26114-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115804.1|ensembl:ENST00000276185(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|interpro:IPR041779|reactome:R-HSA-6798695|ensembl:ENSG00000147234(gene) refseq:YP_001129420.1|interpro:IPR007611(Herpes virus tegument protein U30)|interpro:IPR034738|go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:RojtvQMY4MQmw6Mj4rw7ABfuiz09606 rogid:1pmIA+E5tDlLDKimG8GHCa2amwk37296 rigid:4CqmTKKkZ6T6hUVPdIcvf+J6CvU false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF3 uniprotkb:O43237 intact:EBI-14064132|uniprotkb:Q2HR61 intact:EBI-715294|uniprotkb:Q8TAT3|uniprotkb:A8K6V1|uniprotkb:B4DZP4|ensembl:ENSP00000258198 psi-mi:q76rf3_hhv8(display_long)|uniprotkb:ORF67(gene name)|psi-mi:ORF67(display_short)|uniprotkb:NEC2(gene name synonym)|uniprotkb:HHV8GK18_gp74(orf name) psi-mi:dc1l2_human(display_long)|uniprotkb:Dynein light intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:LIC53/55(gene name synonym)|uniprotkb:DYNC1LI2(gene name)|psi-mi:DYNC1LI2(display_short)|uniprotkb:LIC2(gene name synonym)|uniprotkb:DNCLI2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064130|imex:IM-26114-115 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129424.1|interpro:IPR007626(Herpesvirus virion protein UL34)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044201"(host cell nuclear inner membrane) refseq:NP_006132.1|refseq:NP_001273086.1|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0051642"(centrosome localization)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|go:"GO:0000776"(kinetochore)|go:"GO:0005524"(ATP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|interpro:IPR027417|rcsb pdb:6F1T|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|ensembl:ENSG00000135720(gene)|ensembl:ENST00000258198(transcript) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:7i4/O2JF06Iznuqb6ApO1Q1a68g37296 rogid:WUEd3zgPhcKEe10gtoJ+okX8Zps9606 rigid:9B9NSnP6niy94qKaBkFZQKvPH5E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF3 uniprotkb:Q13370 intact:EBI-14064132|uniprotkb:Q2HR61 intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37 psi-mi:q76rf3_hhv8(display_long)|uniprotkb:ORF67(gene name)|psi-mi:ORF67(display_short)|uniprotkb:NEC2(gene name synonym)|uniprotkb:HHV8GK18_gp74(orf name) psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064130|imex:IM-26114-115 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129424.1|interpro:IPR007626(Herpesvirus virion protein UL34)|go:"GO:0016021"(integral component of membrane)|go:"GO:0044201"(host cell nuclear inner membrane) ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:7i4/O2JF06Iznuqb6ApO1Q1a68g37296 rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606 rigid:9B9NSnP6niy94qKaBkFZQKvPH5E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P12955 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-948765|ensembl:ENSP00000244137|uniprotkb:Q8TBN9|uniprotkb:Q9BT75|uniprotkb:A8K3Z1|uniprotkb:A8K416|uniprotkb:A8K696|uniprotkb:A8MX47|uniprotkb:B4DGJ1|uniprotkb:B4DDB7|uniprotkb:E9PCE8 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:pepd_human(display_long)|uniprotkb:Proline dipeptidase(gene name synonym)|uniprotkb:Imidodipeptidase(gene name synonym)|uniprotkb:Peptidase D(gene name synonym)|uniprotkb:PEPD(gene name)|psi-mi:PEPD(display_short)|uniprotkb:PRD(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) dip:DIP-50038N|ensembl:ENSG00000124299(gene)|ensembl:ENST00000244137(transcript)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006520"(cellular amino acid metabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102009"(proline dipeptidase activity)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR001131(Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site)|interpro:IPR007865(Peptidase M24B, X-Pro dipeptidase/aminopeptidase P N-terminal)|interpro:IPR029149|interpro:IPR036005|rcsb pdb:2IW2|rcsb pdb:2OKN|rcsb pdb:5M4G|rcsb pdb:5M4J|rcsb pdb:5M4L|rcsb pdb:5M4Q|rcsb pdb:5MBY|rcsb pdb:5MBZ|rcsb pdb:5MC0|rcsb pdb:5MC1|rcsb pdb:5MC2|rcsb pdb:5MC3|rcsb pdb:5MC4|rcsb pdb:5MC5|rcsb pdb:6H2P|rcsb pdb:6H2Q|rcsb pdb:6QSB|rcsb pdb:6QSC|rcsb pdb:6SRE|rcsb pdb:6SRF|rcsb pdb:6SRG|refseq:NP_000276.2|refseq:NP_001159529.1|refseq:NP_001159528.1 - - crc64:E8C4A2497E44BA22 figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:S33ZGUuOs+AAE83dREDwbnMKJws9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q9H8M7 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-724928|uniprotkb:Q5SZ68|uniprotkb:Q5SZ69|uniprotkb:Q5SZ70|uniprotkb:Q6IA40|uniprotkb:Q6P7P0|uniprotkb:Q7Z2S1|uniprotkb:Q8WUF1|uniprotkb:Q9H3I4|ensembl:ENSP00000277632 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:miny3_human(display_long)|uniprotkb:MSTP126(orf name)|uniprotkb:My042(orf name)|uniprotkb:MINDY3(gene name)|psi-mi:MINDY3(display_short)|uniprotkb:C10orf97(gene name synonym)|uniprotkb:CARP(gene name synonym)|uniprotkb:DERP5(gene name synonym)|uniprotkb:Dermal papilla-derived protein 5(gene name synonym)|uniprotkb:Deubiquitinating enzyme MINDY-3(gene name synonym)|uniprotkb:FAM188A(gene name synonym)|uniprotkb:Protein CARP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_079224.1|refseq:NP_001305259.1|ensembl:ENSG00000148481(gene)|ensembl:ENST00000277632(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR011992(EF-Hand type)|interpro:IPR025257|interpro:IPR039785|refseq:XP_005252657.1|refseq:XP_005252659.1|refseq:XP_011517996.1|refseq:XP_016872162.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:g6aEz4py3G+v3v35VsWTf4dXq7U9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q86U28 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-10258659|uniprotkb:Q8IYZ0|uniprotkb:A8K3W3|uniprotkb:Q96BB2|uniprotkb:G3V291|uniprotkb:A6NFF1|ensembl:ENSP00000452007 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:isca2_human(display_long)|uniprotkb:ISCA2(gene name)|psi-mi:ISCA2(display_short)|uniprotkb:HBLD1(gene name synonym)|uniprotkb:HESB-like domain-containing protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001258936.1|refseq:NP_919255.2|ensembl:ENSG00000165898(gene)|ensembl:ENST00000556816(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR000361(HesB/YadR/YfhF-like)|interpro:IPR016092(HesB/YadR/YfhF)|interpro:IPR017870|interpro:IPR035903|reactome:R-HSA-1362409 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:mo3MO7EMxmzJkq9+UDuY2weFBpQ9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q06124 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-297779|uniprotkb:Q96HD7|ensembl:ENSP00000340944|uniprotkb:A8K1D9|intact:EBI-14351608|intact:EBI-11988773|intact:EBI-13004965 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:ptn11_human(display_long)|uniprotkb:PTPN11(gene name)|psi-mi:PTPN11(display_short)|uniprotkb:PTP2C(gene name synonym)|uniprotkb:SHPTP2(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 2C(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1D(gene name synonym)|uniprotkb:SH-PTP3(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) rcsb pdb:5I6V|rcsb pdb:5IBM|rcsb pdb:5IBS|rcsb pdb:5X7B|rcsb pdb:5X94|rcsb pdb:5XZR|rcsb pdb:6ATD|rcsb pdb:6BMR|rcsb pdb:6BMU|rcsb pdb:6BMV|rcsb pdb:6BMW|rcsb pdb:6BMX|rcsb pdb:6BMY|rcsb pdb:6BN5|rcsb pdb:6CMP|rcsb pdb:6CMQ|rcsb pdb:6CMR|rcsb pdb:6CMS|rcsb pdb:6CRF|rcsb pdb:6CRG|rcsb pdb:6MD7|rcsb pdb:6MD9|rcsb pdb:6MDA|rcsb pdb:6MDB|rcsb pdb:6MDC|rcsb pdb:6MDD|rcsb pdb:6R5G|rcsb pdb:6WU8|rcsb pdb:7EMN|rcsb pdb:7JVM|rcsb pdb:7JVN|reactome:R-HSA-1059683|reactome:R-HSA-109704|reactome:R-HSA-110056|reactome:R-HSA-112411|rcsb pdb:5EHR|reactome:R-HSA-114604|reactome:R-HSA-1170546|reactome:R-HSA-512988|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-1257604|reactome:R-HSA-5654695|reactome:R-HSA-5654700|reactome:R-HSA-1295596|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-1433557|reactome:R-HSA-180292|reactome:R-HSA-5654733|reactome:R-HSA-186763|reactome:R-HSA-6811558|reactome:R-HSA-210990|reactome:R-HSA-210993|reactome:R-HSA-877312|reactome:R-HSA-8853659|reactome:R-HSA-8854691|reactome:R-HSA-8865999|reactome:R-HSA-8934593|reactome:R-HSA-9008059|reactome:R-HSA-2219530|reactome:R-HSA-2586552|reactome:R-HSA-388841|reactome:R-HSA-389513|reactome:R-HSA-9028731|reactome:R-HSA-389948|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-391160|reactome:R-HSA-936964|reactome:R-HSA-418886|reactome:R-HSA-432142|reactome:R-HSA-9607240|reactome:R-HSA-9645135|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703648|ensembl:ENSG00000179295(gene)|ensembl:ENST00000351677(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|rcsb pdb:3ZM0|rcsb pdb:3ZM1|rcsb pdb:3ZM2|rcsb pdb:3ZM3|interpro:IPR029021|rcsb pdb:4DGP|rcsb pdb:4DGX|interpro:IPR036860|mint:Q06124|rcsb pdb:4GWF|rcsb pdb:4H1O|rcsb pdb:4H34|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4JMG|rcsb pdb:4NWF|rcsb pdb:4NWG|rcsb pdb:4OHD|rcsb pdb:4OHE|rcsb pdb:4OHH|rcsb pdb:4OHI|rcsb pdb:4OHL|rcsb pdb:2SHP|rcsb pdb:3B7O|rcsb pdb:3MOW|rcsb pdb:3O5X|rcsb pdb:3TKZ|rcsb pdb:3TL0|rcsb pdb:4PVG|rcsb pdb:4QSY|rcsb pdb:4RDD|rcsb pdb:5BK8|rcsb pdb:5DF6|rcsb pdb:5EHP|refseq:NP_002825.3|refseq:NP_542168.1|refseq:NP_001317366.1|dip:DIP-516N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:I1qRE/L3Wi7q+l/n0NnjKRQ5vqU9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P56277 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-746397|uniprotkb:Q5HYP9|ensembl:ENSP00000358491|ensembl:ENSP00000358496 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:cmc4_human(display_long)|uniprotkb:CMC4(gene name)|psi-mi:CMC4(display_short)|uniprotkb:C6.1B(gene name synonym)|uniprotkb:MTCP1(gene name synonym)|uniprotkb:MTCP1NB(gene name synonym)|uniprotkb:Mature T-cell proliferation 1 neighbor protein(gene name synonym)|uniprotkb:Mature T-cell proliferation-1 type A(gene name synonym)|uniprotkb:Protein p8 MTCP-1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001018024.1|ensembl:ENSG00000182712(gene)|ensembl:ENST00000369479(transcript)|ensembl:ENST00000369484(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|interpro:IPR009069(MTCP1)|interpro:IPR027179|rcsb pdb:1EI0|rcsb pdb:1HP8|rcsb pdb:2HP8|reactome:R-HSA-1268020 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:iMY+457FXC7itRGGs+PIdOlhfzQ9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q86X55 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P30566 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-2511688|ensembl:ENSP00000485525|uniprotkb:B0QY76|uniprotkb:O75495|uniprotkb:Q5TI34 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:pur8_human(display_long)|uniprotkb:ADSL(gene name)|psi-mi:ADSL(display_short)|uniprotkb:AMPS(gene name synonym)|uniprotkb:Adenylosuccinase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) go:"GO:0014850"(response to muscle activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044208"('de novo' AMP biosynthetic process)|go:"GO:0070626"("(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity")|ensembl:ENSG00000239900(gene)|ensembl:ENST00000623063(transcript)|interpro:IPR000362(Fumarate lyase)|interpro:IPR004769(Adenylosuccinate lyase)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR019468|interpro:IPR020557|interpro:IPR022761|rcsb pdb:2J91|rcsb pdb:2VD6|rcsb pdb:4FFX|rcsb pdb:4FLC|reactome:R-HSA-73817|go:"GO:0001666"(response to hypoxia)|go:"GO:0004018"("N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009060"(aerobic respiration)|refseq:NP_000017.1|refseq:NP_001116850.1|refseq:NP_001304852.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:yBhDdHJgZN1NJDpN2ivKLI4oUG09606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q9P258 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-352547|uniprotkb:Q8IVL9|uniprotkb:Q9BSN6|uniprotkb:Q9NPV8|ensembl:ENSP00000364582|ensembl:ENSP00000364585|ensembl:ENSP00000486099|ensembl:ENSP00000486447 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:rcc2_human(display_long)|uniprotkb:RCC2(gene name)|psi-mi:RCC2(display_short)|uniprotkb:KIAA1470(gene name synonym)|uniprotkb:TD60(gene name synonym)|uniprotkb:Telophase disk protein of 60 kDa(gene name synonym)|uniprotkb:RCC1-like protein TD-60(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001129676.1|refseq:NP_061185.1|ensembl:ENSG00000179051(gene)|ensembl:ENSG00000281540(gene)|ensembl:ENST00000375433(transcript)|ensembl:ENST00000375436(transcript)|ensembl:ENST00000628984(transcript)|ensembl:ENST00000631021(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008017"(microtubule binding)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034506"(chromosome, centromeric core domain)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051301"(cell division)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0072356"(chromosome passenger complex localization to kinetochore)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR028641|mint:Q9P258|rcsb pdb:5GWN|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:z9+0avftBLs4Q3ODFHLEmJtd57A9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q9H1A3 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-2804879|uniprotkb:Q9H1A2|uniprotkb:Q8NBT8|uniprotkb:Q9BWJ7|uniprotkb:Q9Y390|ensembl:ENSP00000350874|ensembl:ENSP00000491526 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:metl9_human(display_long)|uniprotkb:DREV(gene name synonym)|uniprotkb:DORA reverse strand protein(gene name synonym)|uniprotkb:METTL9(gene name)|psi-mi:METTL9(display_short)|uniprotkb:Methyltransferase-like protein 9(gene name synonym)|uniprotkb:CGI-81(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) ensembl:ENSG00000197006(gene)|ensembl:ENSG00000284548(gene)|ensembl:ENST00000358154(transcript)|ensembl:ENST00000638803(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0032259"(methylation)|go:"GO:0106370"(protein-L-histidine N-pros-methyltransferase activity)|interpro:IPR007884(DREV methyltransferase)|interpro:IPR029063|refseq:NP_001070648.1|refseq:NP_057109.3|refseq:NP_001275588.1|refseq:NP_001275589.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:y+kS5qY2f6iIp5xTPC58cOoZfVg9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P56545 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-741533|uniprotkb:O43449|uniprotkb:Q5SQP7|uniprotkb:Q69YI3|uniprotkb:Q86SV0|uniprotkb:Q9H2T8|uniprotkb:A8K2X5|ensembl:ENSP00000338615|ensembl:ENSP00000410474|ensembl:ENSP00000434630|ensembl:ENSP00000436285|uniprotkb:D3DRF5|uniprotkb:Q8IY44|intact:EBI-11742664 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:ctbp2_human(display_long)|uniprotkb:CTBP2(gene name)|psi-mi:CTBP2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001077383.1|refseq:NP_001320.1|refseq:NP_073713.2|refseq:NP_001307943.1|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:P56545|rcsb pdb:2OME|rcsb pdb:4LCJ|rcsb pdb:6WKW|reactome:R-HSA-4641265|reactome:R-HSA-5339700|reactome:R-HSA-9662360|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|ensembl:ENSG00000175029(gene)|ensembl:ENST00000337195(transcript)|ensembl:ENST00000411419(transcript)|ensembl:ENST00000494626(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000531469(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019079"(viral genome replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:XP_011537653.1|refseq:XP_011537655.1|refseq:XP_011537656.1|refseq:XP_011537657.1|refseq:NP_001307941.1|refseq:NP_001307942.1|refseq:XP_005269618.1|refseq:XP_005269621.1|refseq:XP_005269624.1|refseq:XP_005269625.1|refseq:XP_005269626.1|refseq:XP_005269628.1|refseq:XP_005269629.1|refseq:NP_001277143.1|refseq:NP_001277144.1|refseq:XP_006717705.1|refseq:XP_016871245.1|refseq:XP_016871246.1|dip:DIP-42104N|refseq:XP_011537651.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:6sKiqjMRW/ViEvTbQJoaUjgvZtc9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q13363 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-908846|uniprotkb:Q4W5N3|uniprotkb:Q7Z2Q5|ensembl:ENSP00000290921 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:ctbp1_human(display_long)|uniprotkb:CTBP1(gene name)|psi-mi:CTBP1(display_short)|uniprotkb:CTBP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001012632.1|refseq:NP_001319.1|refseq:XP_016863253.1|refseq:XP_016863254.1|refseq:XP_016863255.1|refseq:XP_016863256.1|dip:DIP-24245N|ensembl:ENSG00000159692(gene)|ensembl:ENST00000290921(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019079"(viral genome replication)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090241"(negative regulation of histone H4 acetylation)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:Q13363|rcsb pdb:1MX3|rcsb pdb:4LCE|rcsb pdb:4U6Q|rcsb pdb:4U6S|rcsb pdb:6CDF|rcsb pdb:6CDR|rcsb pdb:6V89|rcsb pdb:6V8A|rcsb pdb:7KWM|reactome:R-HSA-3769402|reactome:R-HSA-3899300|reactome:R-HSA-4641265|reactome:R-HSA-5339700 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:hhYGrtcr0oAQW5x5LfNmxfuRNj49606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q9NZL9 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-10317491|uniprotkb:B2R5Y6|uniprotkb:Q6NYC7|uniprotkb:Q27J92|uniprotkb:Q9BS89|uniprotkb:Q9H3E1|uniprotkb:Q3LIE8|uniprotkb:Q9UJ54|uniprotkb:Q1WAI7|uniprotkb:Q567T7|ensembl:ENSP00000325425 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:mat2b_human(display_long)|uniprotkb:MAT2B(gene name)|psi-mi:MAT2B(display_short)|uniprotkb:Methionine adenosyltransferase II beta(gene name synonym)|uniprotkb:Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase(gene name synonym)|uniprotkb:TGR(gene name synonym)|uniprotkb:MSTP045(orf name)|uniprotkb:Nbla02999(orf name)|uniprotkb:UNQ2435/PRO4995(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_037415.1|refseq:NP_877725.1|ensembl:ENSG00000038274(gene)|ensembl:ENST00000321757(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006556"(S-adenosylmethionine biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0048269"(methionine adenosyltransferase complex)|go:"GO:0048270"(methionine adenosyltransferase regulator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005913(dTDP-4-dehydrorhamnose reductase)|interpro:IPR029903|interpro:IPR036291|rcsb pdb:2YDX|rcsb pdb:2YDY|rcsb pdb:4KTT|rcsb pdb:4KTV|rcsb pdb:4NDN|reactome:R-HSA-156581|reactome:R-HSA-5689880 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:RxXcRktcrFe+9xm7qgSyZoci4rU9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P58546 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-1051736|ensembl:ENSP00000376800 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:mtpn_human(display_long)|uniprotkb:Protein V-1(gene name synonym)|uniprotkb:MTPN(gene name)|psi-mi:MTPN(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_665807.1|ensembl:ENSG00000105887(gene)|ensembl:ENST00000393085(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006584"(catecholamine metabolic process)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010557"(positive regulation of macromolecule biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2000812"(regulation of barbed-end actin filament capping)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P58546|rcsb pdb:3AAA|rcsb pdb:7DF7|rcsb pdb:7DSA|rcsb pdb:7DSB|dip:DIP-50234N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:kdJ8vNN4yI2ye49iYUNAtH538b49606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P36969 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-2510844|uniprotkb:O43381|uniprotkb:Q9UPK2|uniprotkb:Q6PJ59|ensembl:ENSP00000346103 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:gpx4_human(display_long)|uniprotkb:GPX4(gene name)|psi-mi:GPX4(display_short)|uniprotkb:Glutathione peroxidase 4(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_002076.2|refseq:NP_001034936.1|dip:DIP-53543N|reactome:R-HSA-9023661|reactome:R-HSA-9020265|ensembl:ENSG00000167468(gene)|ensembl:ENST00000354171(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008430"(selenium binding)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051258"(protein polymerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0110076"(negative regulation of ferroptosis)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|rcsb pdb:2GS3|rcsb pdb:2OBI|rcsb pdb:5H5Q|rcsb pdb:5H5R|rcsb pdb:5H5S|rcsb pdb:6ELW|rcsb pdb:6HKQ|rcsb pdb:6HN3|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-9018676|reactome:R-HSA-9018896 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:SUjUUl4rV/SKmLkV6WOiM+nusio9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:Q9HA64 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-2512721|ensembl:ENSP00000269373|uniprotkb:Q969F4|uniprotkb:Q9H0U7 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:kt3k_human(display_long)|uniprotkb:FN3KRP(gene name)|psi-mi:FN3KRP(display_short)|uniprotkb:Fructosamine-3-kinase-related protein(gene name synonym)|uniprotkb:Protein-psicosamine 3-kinase FN3KRP(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) ensembl:ENSG00000141560(gene)|ensembl:ENST00000269373(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0016301"(kinase activity)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0102193"(protein-ribulosamine 3-kinase activity)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016477(Ketosamine-3-kinase)|reactome:R-HSA-163841|refseq:NP_078895.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:DbnUHyAgUcfytGqoYbFLv4Bwg7U9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O40945 uniprotkb:P33316 intact:EBI-14064149|uniprotkb:Q77Q39 intact:EBI-353224|uniprotkb:O14785|uniprotkb:Q16708|uniprotkb:Q16860|uniprotkb:Q96Q81|uniprotkb:A8K650|uniprotkb:B4DPR5|uniprotkb:Q6FHN1|uniprotkb:Q6NSA3|ensembl:ENSP00000370376 psi-mi:o40945_hhv8(display_long)|uniprotkb:ORF69(gene name)|psi-mi:ORF69(display_short)|uniprotkb:NEC1(gene name synonym)|uniprotkb:HHV8GK18_gp78(orf name) psi-mi:dut_human(display_long)|uniprotkb:DUT(gene name)|psi-mi:DUT(display_short)|uniprotkb:dUTP pyrophosphatase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064147|imex:IM-26114-117 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR021152|refseq:YP_001129427.1|go:"GO:0016020"(membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0046765"(viral budding from nuclear membrane)|go:"GO:0046872"(metal ion binding) refseq:NP_001020419.1|refseq:NP_001020420.1|refseq:NP_001939.1|rcsb pdb:1Q5U|rcsb pdb:2HQU|rcsb pdb:3ARA|rcsb pdb:3ARN|rcsb pdb:3EHW|rcsb pdb:4MZ5|rcsb pdb:4MZ6|rcsb pdb:5H4J|reactome:R-HSA-499943|ensembl:ENSG00000128951(gene)|ensembl:ENST00000331200(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004170"(dUTP diphosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006226"(dUMP biosynthetic process)|go:"GO:0006260"(DNA replication)|go:"GO:0046081"(dUTP catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008181(DeoxyUTP pyrophosphatase subfamily 1)|interpro:IPR029054|interpro:IPR033704|interpro:IPR036157|rcsb pdb:1Q5H|refseq:NP_001317215.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2020/01/07 rogid:sf8tMMOdK9SPrFvxoe1EbQHtapQ37296 rogid:lHET9Z1Rre4xbVStybz65KJ8QLk9606 rigid:cZBypiSCfr7PSXVOu++FaaL5k4E false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:Q9Y2Z0 intact:EBI-14064183 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:Q4G0N4 intact:EBI-14064183 intact:EBI-10714975|uniprotkb:B5MC93|uniprotkb:Q6UTX5|uniprotkb:Q96NM0|ensembl:ENSP00000371362 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:nakd2_human(display_long)|uniprotkb:Mitochondrial NAD kinase(gene name synonym)|uniprotkb:NAD kinase domain-containing protein 1, mitochondrial(gene name synonym)|uniprotkb:NADK2(gene name)|psi-mi:NADK2(display_short)|uniprotkb:C5orf33(gene name synonym)|uniprotkb:MNADK(gene name synonym)|uniprotkb:NADKD1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_001078880.1|refseq:NP_001274269.1|refseq:NP_001274270.1|refseq:NP_694558.1|ensembl:ENSG00000152620(gene)|ensembl:ENST00000381937(transcript)|go:"GO:0003951"(NAD+ kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR002504(ATP-NAD/AcoX kinase)|interpro:IPR012355(ATP-NAD kinase-like, eukaryotic)|interpro:IPR016064(ATP-NAD kinase, PpnK-type)|interpro:IPR017438(ATP-NAD kinase, PpnK-type, alpha/beta)|reactome:R-HSA-196807 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:FuMnD0CG7LLYTwuSzpavlen42iI9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:P04818 intact:EBI-14064183 intact:EBI-6190719|ensembl:ENSP00000315644|uniprotkb:Q8WYK3|uniprotkb:Q8WYK4 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:tysy_human(display_long)|uniprotkb:TYMS(gene name)|psi-mi:TYMS(display_short)|uniprotkb:TS(gene name synonym)|uniprotkb:OK/SW-cl.29(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 ensembl:ENSG00000176890(gene)|ensembl:ENST00000323274(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0005542"(folic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0006235"(dTTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019860"(uracil metabolic process)|go:"GO:0032259"(methylation)|go:"GO:0032570"(response to progesterone)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046683"(response to organophosphorus)|go:"GO:0048589"(developmental growth)|go:"GO:0051216"(cartilage development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051593"(response to folic acid)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|interpro:IPR023451|interpro:IPR036926|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019048"(modulation by virus of host process)|rcsb pdb:1HVY|rcsb pdb:4O1U|rcsb pdb:4O1X|rcsb pdb:4UP1|rcsb pdb:5HS3|rcsb pdb:5WRN|rcsb pdb:5X4W|rcsb pdb:5X4X|rcsb pdb:5X4Y|rcsb pdb:5X5A|rcsb pdb:4KPW|rcsb pdb:5X5D|rcsb pdb:5X5Q|rcsb pdb:5X66|rcsb pdb:5X67|rcsb pdb:5X69|rcsb pdb:6OJU|rcsb pdb:6OJV|rcsb pdb:6PF3|rcsb pdb:6PF4|rcsb pdb:6PF5|rcsb pdb:6PF6|rcsb pdb:6QXG|rcsb pdb:6QXH|rcsb pdb:6QYQ|rcsb pdb:6R2E|rcsb pdb:6ZXO|reactome:R-HSA-499943|reactome:R-HSA-69205|rcsb pdb:1HW4|rcsb pdb:1HZW|rcsb pdb:1I00|rcsb pdb:1JU6|rcsb pdb:1JUJ|rcsb pdb:1YPV|rcsb pdb:2ONB|rcsb pdb:2RD8|rcsb pdb:2RDA|rcsb pdb:3EAW|rcsb pdb:3EBU|rcsb pdb:3ED7|rcsb pdb:3EDW|rcsb pdb:3EF9|rcsb pdb:3EGY|rcsb pdb:3EHI|rcsb pdb:3EJL|rcsb pdb:3GG5|rcsb pdb:3GH0|rcsb pdb:3GH2|rcsb pdb:3H9K|rcsb pdb:3HB8|rcsb pdb:3N5E|rcsb pdb:3N5G|rcsb pdb:3OB7|rcsb pdb:4E28|rcsb pdb:4FGT|rcsb pdb:1HW3|rcsb pdb:4G2O|rcsb pdb:4G6W|rcsb pdb:4GD7|rcsb pdb:4GYH|rcsb pdb:4H1I|rcsb pdb:4JEF|go:"GO:0009636"(response to toxic substance)|go:"GO:0007568"(aging)|refseq:NP_001062.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:9GWaP/MRO1tyHPXsZ+axd6j8lqM9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:Q02218 intact:EBI-14064183 intact:EBI-747213|intact:EBI-1210683|uniprotkb:Q9UDX0|uniprotkb:D3DVL0|uniprotkb:B4E2U9|uniprotkb:E9PBM1|uniprotkb:Q96DD3|ensembl:ENSP00000222673 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:odo1_human(display_long)|uniprotkb:OGDH(gene name)|psi-mi:OGDH(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_002532.2|refseq:NP_001003941.1|refseq:NP_001158508.1|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0021756"(striatum development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034602"("oxoglutarate dehydrogenase (NAD+) activity")|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0106077"(histone succinylation)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|rcsb pdb:3ERY|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403|ensembl:ENSG00000105953(gene)|ensembl:ENST00000222673(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0021695"(cerebellar cortex development)|dip:DIP-39353N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:B9CSRCmhDYg7n5jSpuDlr2mrxDg9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:P08559 intact:EBI-14064183 intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:P36957 intact:EBI-14064183 intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:P10515 intact:EBI-14064183 intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:O00330 intact:EBI-14064183 intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:P82909 intact:EBI-14064183 intact:EBI-11020727|uniprotkb:Q9H2H4|ensembl:ENSP00000256441|ensembl:ENSP00000482331 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:rt36_human(display_long)|uniprotkb:MRPS36(gene name)|psi-mi:MRPS36(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase component 4(gene name synonym)|uniprotkb:KGD4(gene name synonym)|uniprotkb:DC47(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_150597.1|ensembl:ENSG00000134056(gene)|ensembl:ENSG00000278461(gene)|ensembl:ENST00000256441(transcript)|ensembl:ENST00000613100(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006412"(translation)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|interpro:IPR020373|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:7oEY4QJNE/NCNZXlaqXftm4yTIc9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HBQ9 uniprotkb:O94826 intact:EBI-14064183 intact:EBI-2800236|uniprotkb:D3DN48|ensembl:ENSP00000284320 psi-mi:f5hbq9_hhv8(display_long)|uniprotkb:ORF70(gene name)|psi-mi:ORF70(display_short)|uniprotkb:HHV8GK18_gp12(orf name) psi-mi:tom70_human(display_long)|uniprotkb:TOMM70(gene name)|psi-mi:TOMM70(display_short)|uniprotkb:KIAA0719(gene name synonym)|uniprotkb:TOM70(gene name synonym)|uniprotkb:TOMM70A(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064181|imex:IM-26114-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129361.1|interpro:IPR023451|interpro:IPR000398(Thymidylate synthase, C-terminal)|interpro:IPR020940|go:"GO:0004799"(thymidylate synthase activity)|go:"GO:0006231"(dTMP biosynthetic process)|go:"GO:0032259"(methylation)|interpro:IPR036926 refseq:NP_055635.3|ensembl:ENSG00000154174(gene)|ensembl:ENST00000284320(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098586"(cellular response to virus)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O94826|rcsb pdb:7DHG|rcsb pdb:7KDT|go:"GO:0005741"(mitochondrial outer membrane)|reactome:R-HSA-168928|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-1268020 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:EXx0SacRjTa0oYmxR7miGigWuP037296 rogid:LtRXcptMA0w6Pv/4lksPfPJ4CYY9606 rigid:NpGWY2OU7BTFcvyVPrKRJCQPSRs false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF1 uniprotkb:Q16543 intact:EBI-14064208|uniprotkb:Q77Q37 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q76rf1_hhv8(display_long)|uniprotkb:ORF71(gene name)|psi-mi:ORF71(display_short)|uniprotkb:HHV8GK18_gp80(orf name) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064206|imex:IM-26114-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129429.1|rcsb pdb:3CL3|reactome:R-HSA-140534|interpro:IPR011029(DEATH-like)|interpro:IPR001875(Death effector)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002398(Peptidase C14, caspase precursor p45) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:E/DylQAx/KZDsB9VifhDHWdg7RQ37296 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rigid:TXUJbDlGUIND/BBTG8n0g3fOfYw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF1 uniprotkb:Q9Y6K9 intact:EBI-14064208|uniprotkb:Q77Q37 intact:EBI-81279|intact:EBI-356130|uniprotkb:Q7LBY6|uniprotkb:Q7Z7F1|ensembl:ENSP00000471166|ensembl:ENSP00000479662 psi-mi:q76rf1_hhv8(display_long)|uniprotkb:ORF71(gene name)|psi-mi:ORF71(display_short)|uniprotkb:HHV8GK18_gp80(orf name) psi-mi:nemo_human(display_long)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:FIP-3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064206|imex:IM-26114-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129429.1|rcsb pdb:3CL3|reactome:R-HSA-140534|interpro:IPR011029(DEATH-like)|interpro:IPR001875(Death effector)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002398(Peptidase C14, caspase precursor p45) refseq:NP_001308325.1|refseq:NP_001308326.1|refseq:NP_001093326.2|refseq:NP_001093327.1|refseq:NP_001138727.1|refseq:NP_003630.1|dip:DIP-27528N|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:Q9Y6K9|rcsb pdb:2JVX|rcsb pdb:2JVY|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:3CL3|rcsb pdb:3FX0|rcsb pdb:4BWN|rcsb pdb:5AAY|rcsb pdb:5LDE|rcsb pdb:6MI3|rcsb pdb:6MI4|rcsb pdb:6YEK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-4755510|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:E/DylQAx/KZDsB9VifhDHWdg7RQ37296 rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606 rigid:TXUJbDlGUIND/BBTG8n0g3fOfYw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF1 uniprotkb:O15111 intact:EBI-14064208|uniprotkb:Q77Q37 intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970 psi-mi:q76rf1_hhv8(display_long)|uniprotkb:ORF71(gene name)|psi-mi:ORF71(display_short)|uniprotkb:HHV8GK18_gp80(orf name) psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064206|imex:IM-26114-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129429.1|rcsb pdb:3CL3|reactome:R-HSA-140534|interpro:IPR011029(DEATH-like)|interpro:IPR001875(Death effector)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002398(Peptidase C14, caspase precursor p45) refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:E/DylQAx/KZDsB9VifhDHWdg7RQ37296 rogid:FVB/gXjSBTB9hdq9pycQogxesms9606 rigid:TXUJbDlGUIND/BBTG8n0g3fOfYw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76RF1 uniprotkb:O14920 intact:EBI-14064208|uniprotkb:Q77Q37 intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684 psi-mi:q76rf1_hhv8(display_long)|uniprotkb:ORF71(gene name)|psi-mi:ORF71(display_short)|uniprotkb:HHV8GK18_gp80(orf name) psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064206|imex:IM-26114-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129429.1|rcsb pdb:3CL3|reactome:R-HSA-140534|interpro:IPR011029(DEATH-like)|interpro:IPR001875(Death effector)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002398(Peptidase C14, caspase precursor p45) refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:E/DylQAx/KZDsB9VifhDHWdg7RQ37296 rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606 rigid:TXUJbDlGUIND/BBTG8n0g3fOfYw false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:Q00526 intact:EBI-14064228 intact:EBI-1245761|ensembl:ENSP00000400088|ensembl:ENSP00000410561 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdk3_human(display_long)|uniprotkb:CDK3(gene name)|psi-mi:CDK3(display_short)|uniprotkb:Cell division protein kinase 3(gene name synonym)|uniprotkb:CDKN3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_001249.1|dip:DIP-686N|ensembl:ENSG00000250506(gene)|ensembl:ENST00000425876(transcript)|ensembl:ENST00000448471(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0045023"(G0 to G1 transition)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1LFN - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:3ln4uWhDCiUiI0IcecfT+LKE3MY9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:Q99536 intact:EBI-14064228 intact:EBI-2514883|ensembl:ENSP00000347872|uniprotkb:Q5BKZ7|uniprotkb:A8K345|uniprotkb:Q13035|uniprotkb:Q9BUT8|uniprotkb:Q96A39|uniprotkb:B0AZP7|uniprotkb:B4DPX4 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:vat1_human(display_long)|uniprotkb:VAT1(gene name)|psi-mi:VAT1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 rcsb pdb:6K9Y|rcsb pdb:6LHR|rcsb pdb:6LII|reactome:R-HSA-6798695|ensembl:ENSG00000108828(gene)|ensembl:ENST00000355653(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002364(Quinone oxidoreductase/zeta-crystallin, conserved site)|interpro:IPR011032(GroES-like)|interpro:IPR013154(Alcohol dehydrogenase GroES-like)|interpro:IPR020843|interpro:IPR036291|mint:Q99536|refseq:NP_006364.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:CaICWyJ+h3ry4itndQodektQFQo9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P51149 intact:EBI-14064228 intact:EBI-1056089|uniprotkb:A8K3V6|uniprotkb:Q9NWJ0|uniprotkb:Q9UPB0|ensembl:ENSP00000265062|ensembl:ENSP00000501618|ensembl:ENSP00000502000|ensembl:ENSP00000502088|ensembl:ENSP00000502486 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:rab7a_human(display_long)|uniprotkb:RAB7A(gene name)|psi-mi:RAB7A(display_short)|uniprotkb:RAB7(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_004628.4|ensembl:ENSG00000075785(gene)|ensembl:ENST00000265062(transcript)|ensembl:ENST00000674589(transcript)|ensembl:ENST00000675342(transcript)|ensembl:ENST00000675497(transcript)|ensembl:ENST00000676214(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0022615"(protein to membrane docking)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032419"(extrinsic component of lysosome membrane)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0061724"(lipophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090383"(phagosome acidification)|go:"GO:0090385"(phagosome-lysosome fusion)|go:"GO:0099638"(endosome to plasma membrane protein transport)|go:"GO:1902586"(obsolete multi-organism intercellular transport)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905394"(retromer complex binding)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P51149|rcsb pdb:1T91|rcsb pdb:1YHN|rcsb pdb:6IYB|rcsb pdb:6WCW|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-9636383|reactome:R-HSA-9636569|rcsb pdb:3LAW|dip:DIP-39879N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:AJbKizzw4zCAn+roRF2Im1Tt4xE9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P50990 intact:EBI-14064228 intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P42773 intact:EBI-14064228 intact:EBI-711290|uniprotkb:Q8TB83|ensembl:ENSP00000262662|ensembl:ENSP00000360826|ensembl:ENSP00000379452 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdn2c_human(display_long)|uniprotkb:CDKN2C(gene name)|psi-mi:CDKN2C(display_short)|uniprotkb:CDKN6(gene name synonym)|uniprotkb:p18-INK4c(gene name synonym)|uniprotkb:Cyclin-dependent kinase 6 inhibitor(gene name synonym)|uniprotkb:p18-INK6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_001253.1|refseq:NP_523240.1|ensembl:ENSG00000123080(gene)|ensembl:ENST00000262662(transcript)|ensembl:ENST00000371761(transcript)|ensembl:ENST00000396148(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|mint:P42773|rcsb pdb:1BU9|rcsb pdb:1G3N|rcsb pdb:1IHB|rcsb pdb:1MX2|rcsb pdb:1MX4|rcsb pdb:1MX6|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:Of2GgenNQNEF+WySg8SoGFBfYkE9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P46527 intact:EBI-14064228 intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P42771 intact:EBI-14064228 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:Q00535 intact:EBI-14064228 intact:EBI-1041567|uniprotkb:A1XKG3|ensembl:ENSP00000419782 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdk5_human(display_long)|uniprotkb:CDK5(gene name)|psi-mi:CDK5(display_short)|uniprotkb:Cell division protein kinase 5(gene name synonym)|uniprotkb:Tau protein kinase II catalytic subunit(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PSSALRE(gene name synonym)|uniprotkb:CDKN5(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_001157882.1|refseq:NP_004926.1|ensembl:ENSG00000164885(gene)|ensembl:ENST00000485972(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005176"(ErbB-2 class receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048156"(tau protein binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0051301"(cell division)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070509"(calcium ion import)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901387"(positive regulation of voltage-gated calcium channel activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q00535|rcsb pdb:1H4L|rcsb pdb:1LFR|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:4AU8|reactome:R-HSA-180024|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|reactome:R-HSA-983231|dip:DIP-24221N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:NddS77Gpf0Gt5O3MPylAUfJ7QOE9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:P24941 intact:EBI-14064228 intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:F5HC81 uniprotkb:Q00534 intact:EBI-14064228 intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087 psi-mi:f5hc81_hhv8(display_long)|uniprotkb:ORF72(gene name)|psi-mi:ORF72(display_short)|uniprotkb:HHV8GK18_gp82(orf name) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14064226|imex:IM-26114-139 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129430.1|interpro:IPR013763(Cyclin-related)|interpro:IPR017285(Cyclin, viral)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR015164(K cyclin, C terminal)|interpro:IPR036915|interpro:IPR015451(Cyclin D)|interpro:IPR039361 refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/20 rogid:qWYaLsGPQ01q5vmwr68/NNQHU2M37296 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 rigid:Io6fTaBO3wElHs//OpygCRtxzcQ false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P27694 intact:EBI-14988834 intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P15927 intact:EBI-14988834 intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P35244 intact:EBI-14988834 intact:EBI-621428|ensembl:ENSP00000223129|ensembl:ENSP00000379914|uniprotkb:Q549U6|intact:EBI-1058317 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:rfa3_human(display_long)|uniprotkb:Replication factor A protein 3(gene name synonym)|uniprotkb:RPA3(gene name)|psi-mi:RPA3(display_short)|uniprotkb:REPA3(gene name synonym)|uniprotkb:RPA14(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0035861"(site of double-strand break)|ensembl:ENSG00000106399(gene)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013970(Replication factor A protein 3)|mint:P35244|rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|ensembl:ENST00000223129(transcript)|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|ensembl:ENST00000396682(transcript)|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|refseq:NP_002938.1|dip:DIP-24190N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:hHO7MxGGHUjz30HXSBZd9cXOq6I9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P11171 intact:EBI-14988834 intact:EBI-1050906|uniprotkb:P11176|uniprotkb:Q14245|uniprotkb:Q5TB35|uniprotkb:Q5VXN8|uniprotkb:Q8IXV9|uniprotkb:Q9Y578|uniprotkb:Q9Y579|uniprotkb:B1ALH8|uniprotkb:B1ALH9|uniprotkb:D3DPM9|uniprotkb:D3DPN0|ensembl:ENSP00000345259|ensembl:ENSP00000362904 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:epb41_human(display_long)|uniprotkb:Band 4.1(gene name synonym)|uniprotkb:EPB4.1(gene name synonym)|uniprotkb:4.1R(gene name synonym)|uniprotkb:EPB41(gene name)|psi-mi:EPB41(display_short)|uniprotkb:E41P(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001159477.1|refseq:NP_001159478.1|refseq:NP_004428.1|refseq:NP_976217.1|refseq:XP_016856078.1|refseq:XP_005245818.1|refseq:XP_005245821.1|ensembl:ENSG00000159023(gene)|ensembl:ENST00000343067(transcript)|ensembl:ENST00000373798(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051301"(cell division)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0099738"(cell cortex region)|go:"GO:1904478"(regulation of intestinal absorption)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR021187|interpro:IPR029071|interpro:IPR035963|mint:P11171|rcsb pdb:1GG3|rcsb pdb:2RQ1|rcsb pdb:3QIJ|reactome:R-HSA-6794361|dip:DIP-17032N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:ZCaM+kjScfGP23wRkFRwVyxOyvk9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q8N9R8 intact:EBI-14988834 intact:EBI-4395514|uniprotkb:Q3SXZ1|uniprotkb:Q3SXZ2|uniprotkb:Q5T163|uniprotkb:Q8N1I4|ensembl:ENSP00000336756 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:scai_human(display_long)|uniprotkb:SCAI(gene name)|psi-mi:SCAI(display_short)|uniprotkb:C9orf126(gene name synonym)|uniprotkb:Suppressor of cancer cell invasion protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001138349.1|refseq:NP_775961.2|ensembl:ENSG00000173611(gene)|ensembl:ENST00000336505(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|interpro:IPR016607(Uncharacterised conserved protein UCP013022)|interpro:IPR022709|mint:Q8N9R8|reactome:R-HSA-5663220 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:7rGLwUVUMTIQHugyN2BTnQwluiY9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q8TBX8 intact:EBI-14988834 intact:EBI-1383637|ensembl:ENSP00000347032|ensembl:ENSP00000439878|uniprotkb:Q9H6N2|uniprotkb:B2RDL3|uniprotkb:B4DM11|uniprotkb:B4DY44 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:pi42c_human(display_long)|uniprotkb:PIP4K2C(gene name)|psi-mi:PIP4K2C(display_short)|uniprotkb:PIP5K2C(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II gamma(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000166908(gene)|ensembl:ENST00000354947(transcript)|ensembl:ENST00000540759(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043229"(intracellular organelle)|refseq:NP_001139730.1|refseq:NP_001139731.1|refseq:NP_079055.3|refseq:NP_001139732.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:Q8TBX8|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|rcsb pdb:2GK9|reactome:R-HSA-1660499|reactome:R-HSA-6811555|reactome:R-HSA-6811558|reactome:R-HSA-8847453 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:vC4KtXa6EcyihfFZdCAb3GmQUhs9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q14527 intact:EBI-14988834 intact:EBI-1045161|uniprotkb:Q14536|uniprotkb:Q16051|uniprotkb:Q7KYJ6|uniprotkb:Q86YA5|uniprotkb:Q92652|uniprotkb:Q96KM9|uniprotkb:D3DNH3|ensembl:ENSP00000308944|ensembl:ENSP00000376644|ensembl:ENSP00000420429 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:hltf_human(display_long)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2-like 3(gene name synonym)|uniprotkb:DNA-binding protein/plasminogen activator inhibitor 1 regulator(gene name synonym)|uniprotkb:HIP116(gene name synonym)|uniprotkb:RING finger protein 80(gene name synonym)|uniprotkb:HLTF(gene name)|psi-mi:HLTF(display_short)|uniprotkb:HIP116A(gene name synonym)|uniprotkb:RNF80(gene name synonym)|uniprotkb:SNF2L3(gene name synonym)|uniprotkb:ZBU1(gene name synonym)|uniprotkb:SMARCA3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HLTF(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001305863.1|refseq:NP_001305864.1|refseq:NP_003062.2|refseq:NP_620636.1|refseq:XP_016862568.1|dip:DIP-29828N|ensembl:ENSG00000071794(gene)|ensembl:ENST00000310053(transcript)|ensembl:ENST00000392912(transcript)|ensembl:ENST00000494055(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014905(HIRAN)|interpro:IPR017907|interpro:IPR027417|interpro:IPR038718|mint:Q14527|rcsb pdb:2MZN|rcsb pdb:4HRE|rcsb pdb:4HRH|rcsb pdb:4S0N|rcsb pdb:4XZF|rcsb pdb:4XZG|rcsb pdb:5BNH|rcsb pdb:5K5F|rcsb pdb:6KCS|reactome:R-HSA-8866654 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:ozxGwYPSrDJ+Fg3F64VfE0Bc0wM9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P48426 intact:EBI-14988834 intact:EBI-3924422|uniprotkb:Q5VUX3|uniprotkb:D3DRV1|uniprotkb:B0YJ66|uniprotkb:P53807|ensembl:ENSP00000365757|uniprotkb:B4DGX2 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:pi42a_human(display_long)|uniprotkb:PIP4K2A(gene name)|psi-mi:PIP4K2A(display_short)|uniprotkb:PIP5K2(gene name synonym)|uniprotkb:PIP5K2A(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:PIP5KIII(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase B isoform"(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase C isoform"(gene name synonym)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:PI5P4KA(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_005019.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|ensembl:ENST00000376573(transcript)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:P48426|rcsb pdb:2YBX|rcsb pdb:6OSP|rcsb pdb:6UX9|rcsb pdb:6YM3|rcsb pdb:6YM4|rcsb pdb:6YM5|rcsb pdb:7N6Z|rcsb pdb:7N7J|rcsb pdb:7N7K|rcsb pdb:7N7L|rcsb pdb:7N7M|rcsb pdb:7N7N|rcsb pdb:7N7O|reactome:R-HSA-1660499|reactome:R-HSA-6811555|reactome:R-HSA-6811558|reactome:R-HSA-8847453|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|ensembl:ENSG00000150867(gene)|refseq:NP_001316991.1|refseq:XP_016871819.1|refseq:XP_016871820.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:Fmsp/H2ucCjs7wyiCgEqe9Y5UT49606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:O75521 intact:EBI-14988834 intact:EBI-2512024|ensembl:ENSP00000369461|uniprotkb:Q9NYH7|uniprotkb:Q9NQH1|uniprotkb:Q9H0T9|uniprotkb:Q5JYK7|uniprotkb:Q7L124|uniprotkb:Q9UN55|uniprotkb:Q9BUE9|uniprotkb:Q8N0X0|uniprotkb:Q5JYK5|intact:EBI-2802486 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:eci2_human(display_long)|uniprotkb:ECI2(gene name)|psi-mi:ECI2(display_short)|uniprotkb:DRS1(gene name synonym)|uniprotkb:HCA88(gene name synonym)|uniprotkb:Dodecenoyl-CoA isomerase(gene name synonym)|uniprotkb:"Delta(3),delta(2)-enoyl-CoA isomerase"(gene name synonym)|uniprotkb:Diazepam-binding inhibitor-related protein 1(gene name synonym)|uniprotkb:DRS-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 88(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-1(gene name synonym)|uniprotkb:PECI(gene name synonym)|uniprotkb:Peroxisomal 3,2-trans-enoyl-CoA isomerase(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000198721(gene)|ensembl:ENST00000380118(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004165"("delta(3)-delta(2)-enoyl-CoA isomerase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR022408|interpro:IPR029045|interpro:IPR035984|mint:O75521|rcsb pdb:2CQU|rcsb pdb:2F6Q|rcsb pdb:4U18|rcsb pdb:4U19|rcsb pdb:4U1A|reactome:R-HSA-390247|reactome:R-HSA-9033241|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR001753(Crotonase, core)|refseq:NP_001159482.1|refseq:NP_006108.2|refseq:NP_996667.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:AIR8lybsBusmVmjgsN0Hcl6p+3g9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q96JN8 intact:EBI-14988834 intact:EBI-1053406|uniprotkb:Q6GPI8|uniprotkb:Q96IU9|uniprotkb:Q9H0B0|intact:EBI-2563327|intact:EBI-28979128|ensembl:ENSP00000382390|ensembl:ENSP00000500916 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:neul4_human(display_long)|uniprotkb:NEURL4(gene name)|psi-mi:NEURL4(display_short)|uniprotkb:KIAA1787(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001005408.1|refseq:NP_115818.2|ensembl:ENST00000315614|ensembl:ENSP00000319826|ensembl:ENSP00000382390|ensembl:ENSP00000500916|ensembl:ENST00000673081|ensembl:ENSP00000500667|ensembl:ENSG00000215041(gene)|ensembl:ENSG00000288301(gene)|ensembl:ENST00000399464(transcript)|ensembl:ENST00000671847(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q96JN8|rcsb pdb:2E63 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:lydZRBsnJDyAdaDjTe7gJVkxL149606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9UGN5 intact:EBI-14988834 intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P0C0S5 intact:EBI-14988834 intact:EBI-1199859|uniprotkb:P17317|uniprotkb:Q6I9U0|uniprotkb:B2RD56|ensembl:ENSP00000296417 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:h2az_human(display_long)|uniprotkb:H2AZ1(gene name)|psi-mi:H2AZ1(display_short)|uniprotkb:H2AFZ(gene name synonym)|uniprotkb:H2AZ(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_002097.1|ensembl:ENSG00000164032(gene)|ensembl:ENST00000296417(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S5|rcsb pdb:1F66|rcsb pdb:3WA9|rcsb pdb:4CAY|rcsb pdb:4NFT|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5CHL|rcsb pdb:5FUG|rcsb pdb:5Z30|rcsb pdb:6JOU|rcsb pdb:6KO2|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|dip:DIP-38593N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:0FrzM1TXlduSQ0NNVl0C9uqCUGI9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q71UI9 intact:EBI-14988834 intact:EBI-2954755|ensembl:ENSP00000308405|uniprotkb:A8MQC5|uniprotkb:Q6PK98|uniprotkb:Q59GV8|uniprotkb:A6NN01|uniprotkb:A6NKY0|uniprotkb:A6NFA8 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:h2av_human(display_long)|uniprotkb:H2AZ2(gene name)|psi-mi:H2AZ2(display_short)|uniprotkb:H2A.F/Z(gene name synonym)|uniprotkb:H2A.Z variant histone 2(gene name synonym)|uniprotkb:H2AFV(gene name synonym)|uniprotkb:H2AV(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 interpro:IPR007125(Histone core)|interpro:IPR002119(Histone H2A)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:3WAA|rcsb pdb:6M4D|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-9018519|ensembl:ENSG00000105968(gene)|ensembl:ENST00000308153(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|refseq:NP_036544.1|refseq:NP_619541.1|refseq:NP_958844.1|refseq:NP_958924.1|refseq:NP_958925.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:HWEdsnxjwV2Z0BAbsziMwaE/gXE9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9Y2J2 intact:EBI-14988834 intact:EBI-310986|uniprotkb:O95713|uniprotkb:Q9BRP5|ensembl:ENSP00000343158|uniprotkb:B7Z4I5|uniprotkb:F5GX05 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:e41l3_human(display_long)|uniprotkb:EPB41L3(gene name)|psi-mi:EPB41L3(display_short)|uniprotkb:DAL1(gene name synonym)|uniprotkb:KIAA0987(gene name synonym)|uniprotkb:4.1B(gene name synonym)|uniprotkb:Differentially expressed in adenocarcinoma of the lung protein 1(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_036439.2|refseq:NP_001268462.1|refseq:NP_001268463.1|refseq:NP_001268464.1|ensembl:ENSG00000082397(gene)|ensembl:ENST00000341928(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030054"(cell junction)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0033270"(paranode region of axon)|go:"GO:0043217"(myelin maintenance)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030691|interpro:IPR035963|mint:Q9Y2J2|rcsb pdb:2HE7|rcsb pdb:3BIN|rcsb pdb:5RYM|rcsb pdb:5RYN|rcsb pdb:5RYO|rcsb pdb:5RYP|rcsb pdb:5RYQ|rcsb pdb:5RYR|rcsb pdb:5RYS|rcsb pdb:5RYT|rcsb pdb:5RYU|rcsb pdb:5RYV|rcsb pdb:5RYW|rcsb pdb:5RYX|rcsb pdb:5RYY|rcsb pdb:5RYZ|rcsb pdb:5RZ0|rcsb pdb:5RZ1|rcsb pdb:5RZ2|rcsb pdb:5RZ3|rcsb pdb:5RZ4|rcsb pdb:5RZ5|rcsb pdb:5RZ6|rcsb pdb:5RZ7|rcsb pdb:5RZ8|rcsb pdb:5RZ9|rcsb pdb:5RZA|rcsb pdb:5RZB|rcsb pdb:5RZC|rcsb pdb:5RZD|rcsb pdb:5RZE|rcsb pdb:5RZF|rcsb pdb:5RZG|rcsb pdb:5RZH|rcsb pdb:5RZI|rcsb pdb:5RZJ|rcsb pdb:5RZK|rcsb pdb:5RZL|rcsb pdb:5RZM|rcsb pdb:5RZN|rcsb pdb:5RZO|rcsb pdb:5RZP|rcsb pdb:5RZQ|rcsb pdb:5RZR|rcsb pdb:5RZS|rcsb pdb:5RZT|rcsb pdb:5RZU|rcsb pdb:5RZV|rcsb pdb:5RZW|rcsb pdb:5RZX|rcsb pdb:5RZY|rcsb pdb:5RZZ|rcsb pdb:5S00|rcsb pdb:6IBE|reactome:R-HSA-6794361|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:XP_016881125.1|dip:DIP-17035N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:Uwq5dqLRdgFLPBhXZROSRJstl709606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P51608 intact:EBI-14988834 intact:EBI-1189067|uniprotkb:O15233|uniprotkb:Q6QHH9|uniprotkb:Q7Z384|ensembl:ENSP00000301948 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:mecp2_human(display_long)|uniprotkb:MECP2(gene name)|psi-mi:MECP2(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001104262.1|refseq:NP_004983.1|refseq:NP_001303266.1|ensembl:ENSG00000169057(gene)|ensembl:ENST00000303391(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001964"(startle response)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006342"|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006576"(cellular biogenic amine metabolic process)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0007616"(long-term memory)|go:"GO:0008104"(protein localization)|go:"GO:0008211"(glucocorticoid metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010385"(double-stranded methylated DNA binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016358"(dendrite development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016571"(histone methylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0019230"(proprioception)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021591"(ventricular system development)|go:"GO:0032048"(cardiolipin metabolic process)|go:"GO:0035176"(social behavior)|go:"GO:0035197"(siRNA binding)|go:"GO:0042551"(neuron maturation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:0051707"(response to other organism)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0098794"(postsynapse)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1905643"(positive regulation of DNA methylation)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR017353(Methyl-CpG binding protein MeCP2)|mint:P51608|rcsb pdb:1QK9|rcsb pdb:3C2I|rcsb pdb:5BT2|rcsb pdb:6C1Y|rcsb pdb:6OGJ|rcsb pdb:6OGK|reactome:R-HSA-8986944|reactome:R-HSA-9022534|reactome:R-HSA-9022535|reactome:R-HSA-9022537|reactome:R-HSA-9022538|reactome:R-HSA-9022692|reactome:R-HSA-9022699|reactome:R-HSA-9022702|reactome:R-HSA-9022707|reactome:R-HSA-9022927|dip:DIP-39983N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:7c5ZZAZsqV7AciGN4hzFNWJLeUk9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P15336 intact:EBI-14988834 intact:EBI-1170906|uniprotkb:Q13000|uniprotkb:Q4ZFU9|uniprotkb:Q53RY2|uniprotkb:A1L3Z2|uniprotkb:D3DPE9|uniprotkb:Q8TAR1|uniprotkb:A4D7U4|uniprotkb:G8JLM5|uniprotkb:Q3B7B7|uniprotkb:A4D7U5|uniprotkb:A4D7V1|uniprotkb:Q96JT8|intact:EBI-28988937|ensembl:ENSP00000264110|ensembl:ENSP00000376327 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:atf2_human(display_long)|uniprotkb:ATF2(gene name)|psi-mi:ATF2(display_short)|uniprotkb:CREB2(gene name synonym)|uniprotkb:CREBP1(gene name synonym)|uniprotkb:Activating transcription factor 2(gene name synonym)|uniprotkb:cAMP response element-binding protein CRE-BP1(gene name synonym)|uniprotkb:HB16(gene name synonym)|uniprotkb:Cyclic AMP-responsive element-binding protein 2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001243019.1|refseq:NP_001243020.1|refseq:NP_001871.2|refseq:NP_001243023.1|ensembl:ENST00000345739|ensembl:ENSP00000340576|ensembl:ENSP00000376327|ensembl:ENST00000409499|ensembl:ENSP00000386282|ensembl:ENST00000409635|ensembl:ENSP00000387093|ensembl:ENST00000409833|ensembl:ENSP00000386526|ensembl:ENST00000426833|ensembl:ENSP00000407911|ensembl:ENSP00000264110|refseq:NP_001243021.1|refseq:NP_001243022.1|ensembl:ENSG00000115966(gene)|ensembl:ENST00000264110(transcript)|ensembl:ENST00000392544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009414"(response to water deprivation)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0110024"(positive regulation of cardiac muscle myoblast proliferation)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902562"(H4 histone acetyltransferase complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR016378(Transcription factor, cyclic AMP-dependent)|interpro:IPR029836|interpro:IPR036236|mint:P15336|rcsb pdb:1BHI|rcsb pdb:1T2K|rcsb pdb:4H36|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|rcsb pdb:6ZQS|rcsb pdb:6ZR5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-450341|reactome:R-HSA-6796648|reactome:R-HSA-8943724|reactome:R-HSA-9018519|reactome:R-HSA-9031628|reactome:R-HSA-9633012|reactome:R-HSA-9707616|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043969"(histone H2B acetylation)|go:"GO:0044013"(H2B histone acetyltransferase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060612"(adipose tissue development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0097186"(amelogenesis)|dip:DIP-632N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:9krWq+A9Y3xvkInqyJnJs1g9tfc9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q14195 intact:EBI-14988834 intact:EBI-1104726|uniprotkb:Q93012|ensembl:ENSP00000381526|uniprotkb:B3SXQ8 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:dpyl3_human(display_long)|uniprotkb:DPYSL3(gene name)|psi-mi:DPYSL3(display_short)|uniprotkb:CRMP4(gene name synonym)|uniprotkb:DRP3(gene name synonym)|uniprotkb:ULIP(gene name synonym)|uniprotkb:ULIP1(gene name synonym)|uniprotkb:Collapsin response mediator protein 4(gene name synonym)|uniprotkb:Unc-33-like phosphoprotein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000113657(gene)|ensembl:ENST00000398514(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016810"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds")|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031005"(filamin binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0048666"(neuron development)|go:"GO:0048678"(response to axon injury)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR006680(Amidohydrolase 1)|interpro:IPR011059(Metal-dependent hydrolase, composite)|interpro:IPR011778(D-hydantoinase)|interpro:IPR030628|interpro:IPR032466|rcsb pdb:4BKN|rcsb pdb:4CNS|rcsb pdb:4CNT|rcsb pdb:4CNU|reactome:R-HSA-399956|refseq:NP_001184223.1|refseq:NP_001378.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:L+A3ff3KuMbKlfygxHUu+M749MI9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q96RR1 intact:EBI-14988834 intact:EBI-716458|uniprotkb:Q6MZX2|uniprotkb:Q96RR0|uniprotkb:Q6PJP5|uniprotkb:B2CQL2|ensembl:ENSP00000309595 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:peo1_human(display_long)|uniprotkb:TWNK(gene name)|psi-mi:TWNK(display_short)|uniprotkb:C10orf2(gene name synonym)|uniprotkb:PEO1(gene name synonym)|uniprotkb:Progressive external ophthalmoplegia 1 protein(gene name synonym)|uniprotkb:T7 gp4-like protein with intramitochondrial nucleoid localization(gene name synonym)|uniprotkb:T7-like mitochondrial DNA helicase(gene name synonym)|uniprotkb:Twinkle protein, mitochondrial(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001157284.1|refseq:NP_068602.2|ensembl:ENST00000311916(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|ensembl:ENSG00000107815(gene)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR027417|interpro:IPR034154|mint:Q96RR1|reactome:R-HSA-2151201 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:asX2NETd8o4GZrWe8gIUntbtUpA9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q01831 intact:EBI-14988834 intact:EBI-372610|uniprotkb:B4DIP3|uniprotkb:E9PH69|uniprotkb:Q53GT7|uniprotkb:Q96AX0|ensembl:ENSP00000285021|uniprotkb:E9PB96 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:xpc_human(display_long)|uniprotkb:Xeroderma pigmentosum group C-complementing protein(gene name synonym)|uniprotkb:p125(gene name synonym)|uniprotkb:XPC(gene name)|psi-mi:XPC(display_short)|uniprotkb:XPCC(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_004619.3|ensembl:ENSG00000154767(gene)|ensembl:ENST00000285021(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000111"(nucleotide-excision repair factor 2 complex)|go:"GO:0000404"(heteroduplex DNA loop binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010224"(response to UV-B)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071942"(XPC complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990731"(UV-damage excision repair, DNA incision)|interpro:IPR004583(DNA repair protein Rad4)|interpro:IPR018026|interpro:IPR018325|interpro:IPR018326|interpro:IPR018327|interpro:IPR018328|interpro:IPR036985|go:"GO:0042493"|interpro:IPR038765|interpro:IPR042488|mint:Q01831|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2OBH|rcsb pdb:2RVB|reactome:R-HSA-3108214|reactome:R-HSA-5696394|reactome:R-HSA-5696395|dip:DIP-31225N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:PP5XknINbZu7HQiFuOLzUQoaixg9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P18887 intact:EBI-14988834 intact:EBI-947466|uniprotkb:Q9HCB1|uniprotkb:Q6IBS4|ensembl:ENSP00000262887 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:xrcc1_human(display_long)|uniprotkb:XRCC1(gene name)|psi-mi:XRCC1(display_short)|uniprotkb:X-ray repair cross-complementing protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_006288.2|dip:DIP-39067N|ensembl:ENSG00000073050(gene)|ensembl:ENST00000262887(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0010033"(response to organic substance)|go:"GO:0010836"(negative regulation of protein ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021766"(hippocampus development)|go:"GO:0032356"(oxidized DNA binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904877"(positive regulation of DNA ligase activity)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990599"(3' overhang single-stranded DNA endodeoxyribonuclease activity)|interpro:IPR001357(BRCT)|interpro:IPR002706(DNA-repair protein Xrcc1, N-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036420|mint:P18887|rcsb pdb:1CDZ|rcsb pdb:1XNA|rcsb pdb:1XNT|rcsb pdb:2D8M|rcsb pdb:2W3O|rcsb pdb:3K75|rcsb pdb:3K77|rcsb pdb:3LQC|rcsb pdb:5E6Q|rcsb pdb:5W7X|rcsb pdb:5W7Y|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:96hETrBzHYhHX9FC5dZpKnFcjDg9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q6ZU65 intact:EBI-14988834 intact:EBI-9661773|uniprotkb:A4D1S2|uniprotkb:Q2YDY4|uniprotkb:Q6P1K0|uniprotkb:Q86XN9|uniprotkb:Q8N7D1|ensembl:ENSP00000418648 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:ubn2_human(display_long)|uniprotkb:UBN2(gene name)|psi-mi:UBN2(display_short)|uniprotkb:KIAA2030(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSP00000418648|refseq:NP_775840.3|dip:DIP-47312N|ensembl:ENSG00000157741(gene)|ensembl:ENST00000473989(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|interpro:IPR014840("Histone promoter control 2 (HPC2)")|interpro:IPR026943|interpro:IPR026947|mint:Q6ZU65 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:Z45kNtHT1rLdgqkCTrcRGD7L2749606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9NUW8 intact:EBI-14988834 intact:EBI-2902553|ensembl:ENSP00000337353|ensembl:ENSP00000377099|uniprotkb:Q2HXX4|uniprotkb:Q96BK7|uniprotkb:Q9NZM7|uniprotkb:Q9NZM8|uniprotkb:Q86TV8 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:tydp1_human(display_long)|uniprotkb:TDP1(gene name)|psi-mi:TDP1(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000042088(gene)|ensembl:ENST00000335725(transcript)|ensembl:ENST00000393454(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0017005"(3'-tyrosyl-DNA phosphodiesterase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010347(Tyrosyl-DNA phosphodiesterase)|mint:Q9NUW8|rcsb pdb:1JY1|rcsb pdb:1MU7|rcsb pdb:1MU9|rcsb pdb:1NOP|rcsb pdb:1QZQ|rcsb pdb:1RFF|rcsb pdb:1RFI|rcsb pdb:1RG1|rcsb pdb:1RG2|rcsb pdb:1RGT|rcsb pdb:1RGU|rcsb pdb:1RH0|rcsb pdb:5NW9|rcsb pdb:5NWA|rcsb pdb:6DHU|rcsb pdb:6DIE|rcsb pdb:6DIH|rcsb pdb:6DIM|rcsb pdb:6DJD|rcsb pdb:6DJE|rcsb pdb:6DJF|rcsb pdb:6DJG|rcsb pdb:6DJH|rcsb pdb:6DJI|rcsb pdb:6DJJ|rcsb pdb:6MJ5|rcsb pdb:6MYZ|rcsb pdb:6MZ0|rcsb pdb:6N0D|rcsb pdb:6N0N|rcsb pdb:6N0O|rcsb pdb:6N0R|rcsb pdb:6N17|rcsb pdb:6N19|rcsb pdb:6W4R|rcsb pdb:6W7J|rcsb pdb:6W7K|rcsb pdb:6W7L|reactome:R-HSA-5693571|refseq:XP_011535244.1|refseq:XP_011535245.1|refseq:NP_001008744.1|refseq:NP_060789.2|refseq:XP_006720260.1|refseq:XP_006720261.1|refseq:XP_016876928.1|refseq:XP_016876931.1|refseq:XP_016876932.1|refseq:XP_016876933.1|refseq:XP_005267904.1|refseq:XP_005267905.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:7ain8+0TMD1xcADMpcQ0WKn4aIc9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q93077 intact:EBI-14988834 intact:EBI-725259|uniprotkb:O00775|uniprotkb:O00776|uniprotkb:O00777|uniprotkb:O00778|uniprotkb:Q540R1|uniprotkb:B2R4F7|ensembl:ENSP00000321389|ensembl:ENSP00000367022|ensembl:ENSP00000473534 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:h2a1c_human(display_long)|uniprotkb:H2AC6(gene name)|psi-mi:H2AC6(display_short)|uniprotkb:H2A-clustered histone 6(gene name synonym)|uniprotkb:H2AFL(gene name synonym)|uniprotkb:HIST1H2AC(gene name synonym)|uniprotkb:Histone H2A/l(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_003503.1|ensembl:ENSG00000180573(gene)|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|ensembl:ENST00000314088(transcript)|ensembl:ENST00000377791(transcript)|ensembl:ENST00000602637(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|rcsb pdb:6C0W|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:7A08|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|interpro:IPR032458 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:m00IdooZksbNGKHSsaVvGFVpcko9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q7L7L0 intact:EBI-14988834 intact:EBI-5325551|ensembl:ENSP00000355656|ensembl:ENSP00000493926|uniprotkb:B2R4S4 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:h2a3_human(display_long)|uniprotkb:H2AW(gene name)|psi-mi:H2AW(display_short)|uniprotkb:HIST3H2A(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000181218(gene)|ensembl:ENSG00000284841(gene)|ensembl:ENST00000366695(transcript)|refseq:NP_254280.1|ensembl:ENST00000645741(transcript)|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-5689603|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:Q7L7L0|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|go:"GO:0000786"(nucleosome)|dip:DIP-48936N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:t0RdR1SmUtmwRjtCS3uTyLGqSUI9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P78356 intact:EBI-14988834 intact:EBI-947090|uniprotkb:Q5U0E8|uniprotkb:Q8TBP2|ensembl:ENSP00000480776|ensembl:ENSP00000482548 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:pi42b_human(display_long)|uniprotkb:PIP4K2B(gene name)|psi-mi:PIP4K2B(display_short)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-beta"(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-beta(gene name synonym)|uniprotkb:PIP5K2B(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-beta(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II beta(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_003550.1|ensembl:ENSG00000276293(gene)|ensembl:ENSG00000277292(gene)|ensembl:ENST00000613180(transcript)|ensembl:ENST00000619039(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:P78356|rcsb pdb:1BO1|rcsb pdb:3WZZ|rcsb pdb:3X01|rcsb pdb:3X02|rcsb pdb:3X03|rcsb pdb:3X04|rcsb pdb:3X05|rcsb pdb:3X06|rcsb pdb:3X07|rcsb pdb:3X08|rcsb pdb:3X09|rcsb pdb:3X0A|rcsb pdb:3X0B|rcsb pdb:3X0C|rcsb pdb:6K4G|rcsb pdb:6K4H|rcsb pdb:7N80|rcsb pdb:7N81|reactome:R-HSA-1660499|reactome:R-HSA-6811555|reactome:R-HSA-6811558|reactome:R-HSA-8847453 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:sKU3t4ChBZODcGl1ZUqfncyNkSo9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P54198 intact:EBI-14988834 intact:EBI-372342|uniprotkb:Q05BU9|uniprotkb:Q8IXN2|ensembl:ENSP00000263208 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:hira_human(display_long)|uniprotkb:HIRA(gene name)|psi-mi:HIRA(display_short)|uniprotkb:TUP1-like enhancer of split protein 1(gene name synonym)|uniprotkb:DGCR1(gene name synonym)|uniprotkb:HIR(gene name synonym)|uniprotkb:TUPLE1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_003316.3|dip:DIP-29240N|ensembl:ENSG00000100084(gene)|ensembl:ENST00000263208(transcript)|go:"GO:0000417"(HIR complex)|go:"GO:0000785"(chromatin)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016605"(PML body)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR011494(TUP1-like enhancer of split)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031120|interpro:IPR036322|mint:P54198|rcsb pdb:2I32|rcsb pdb:5YJE|reactome:R-HSA-2559584 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:en6l6z4CNWhF4Wlj5ou4DDTfETg9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q8IV63 intact:EBI-14988834 intact:EBI-1058605|uniprotkb:Q502Y2|uniprotkb:Q9P2V8|uniprotkb:A8KA53|intact:EBI-1795523|uniprotkb:A6NEG5|ensembl:ENSP00000324636|ensembl:ENSP00000469880|ensembl:ENSP00000473171 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:vrk3_human(display_long)|uniprotkb:VRK3(gene name)|psi-mi:VRK3(display_short)|uniprotkb:Vaccinia-related kinase 3(gene name synonym)|uniprotkb:Serine/threonine-protein pseudokinase VRK3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_001295349.1|refseq:NP_057524.3|refseq:NP_001020949.1|ensembl:ENSG00000105053(gene)|ensembl:ENST00000316763(transcript)|ensembl:ENST00000594948(transcript)|ensembl:ENST00000599538(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR026870|rcsb pdb:2JII|reactome:R-HSA-202670|refseq:XP_005259028.1|refseq:XP_005259029.1|refseq:XP_006723300.1|refseq:XP_006723301.1|refseq:XP_011525325.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:eoBtIgSkVcOE5bw/By6UEqbiO/I9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9UER7 intact:EBI-14988834 intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q4KMP7 intact:EBI-14988834 intact:EBI-4402442|uniprotkb:B9A6L0|uniprotkb:Q6IN54|uniprotkb:Q6P530|uniprotkb:Q71RG7|uniprotkb:Q86VC5|uniprotkb:Q9H8Z2|uniprotkb:Q9NUN6|uniprotkb:Q9UFP2|ensembl:ENSP00000386538 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:tb10b_human(display_long)|uniprotkb:TBC1D10B(gene name)|psi-mi:TBC1D10B(display_short)|uniprotkb:Rab27A-GAP-beta(gene name synonym)|uniprotkb:FP2461(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_056342.3|ensembl:ENSG00000169221(gene)|ensembl:ENST00000409939(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|reactome:R-HSA-8854214 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:B3iC6bxsYI7npYmPuaRVztl7ytc9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:P49916 intact:EBI-14988834 intact:EBI-1753381|intact:EBI-1058758|uniprotkb:Q16714|uniprotkb:Q6NVK3|ensembl:ENSP00000367787|uniprotkb:E5KLB5|uniprotkb:E5KLB6 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:dnli3_human(display_long)|uniprotkb:LIG3(gene name)|psi-mi:LIG3(display_short)|uniprotkb:DNA ligase III(gene name synonym)|uniprotkb:Polydeoxyribonucleotide synthase [ATP] 3(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_002302.2|refseq:NP_039269.2|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070421"(DNA ligase III-XRCC1 complex)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090298"(negative regulation of mitochondrial DNA replication)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR000977(ATP-dependent DNA ligase)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR012308(DNA ligase, N-terminal)|interpro:IPR012309(ATP dependent DNA ligase, C-terminal)|interpro:IPR012310(ATP dependent DNA ligase, central)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR016059(ATP-dependent DNA ligase, conserved site)|interpro:IPR031916|interpro:IPR036420|interpro:IPR036599|interpro:IPR036957|mint:P49916|rcsb pdb:1IMO|rcsb pdb:1IN1|rcsb pdb:1UW0|rcsb pdb:3L2P|rcsb pdb:3PC7|rcsb pdb:3PC8|rcsb pdb:3QVG|rcsb pdb:6WH1|reactome:R-HSA-110381|reactome:R-HSA-5649702|reactome:R-HSA-5685939|reactome:R-HSA-5696397|reactome:R-HSA-6782210|ensembl:ENSG00000005156(gene)|ensembl:ENST00000378526(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003909"(DNA ligase activity)|go:"GO:0003910"("DNA ligase (ATP) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006266"(DNA ligation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006288"(base-excision repair, DNA ligation)|go:"GO:0006302"(double-strand break repair)|refseq:XP_016880113.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:+GqYPnth9+VqCoh1TvPG4yEDLeo9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9NPG3 intact:EBI-14988834 intact:EBI-2880187|ensembl:ENSP00000262376|ensembl:ENSP00000379894|uniprotkb:B7Z6D3|uniprotkb:Q13079|uniprotkb:Q9P1P7|uniprotkb:D3DUE8 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:ubn1_human(display_long)|uniprotkb:UBN1(gene name)|psi-mi:UBN1(display_short)|uniprotkb:HIRA-binding protein(gene name synonym)|uniprotkb:Protein VT4(gene name synonym)|uniprotkb:Ubiquitously expressed nuclear protein(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000118900(gene)|ensembl:ENST00000262376(transcript)|ensembl:ENST00000396658(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0034451"(centriolar satellite)|interpro:IPR014840("Histone promoter control 2 (HPC2)")|interpro:IPR026936|interpro:IPR026947|mint:Q9NPG3|rcsb pdb:4ZBJ|reactome:R-HSA-2559584|go:"GO:0005654"(nucleoplasm)|refseq:NP_001072982.1|refseq:XP_016878678.1|refseq:NP_001275585.1|ensembl:ENSP00000262376|ensembl:ENSP00000379894|ensembl:ENST00000590769|ensembl:ENSP00000468740 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:IT0lTmzNcbWFQVVD5DfATSqxjwg9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q8IUE6 intact:EBI-14988834 intact:EBI-1642157|ensembl:ENSP00000332790 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:h2a2b_human(display_long)|uniprotkb:H2AC21(gene name)|psi-mi:H2AC21(display_short)|uniprotkb:H2A-clustered histone 21(gene name synonym)|uniprotkb:HIST2H2AB(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 refseq:NP_778235.1|ensembl:ENSG00000184270(gene)|ensembl:ENST00000331128(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:Q8IUE6|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:1F8W3E3hVpwLzJsW/37w8XshfOE9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:O95714 intact:EBI-14988834 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:D0UZU1 uniprotkb:Q9Y4C1 intact:EBI-14988834 intact:EBI-2515339|ensembl:ENSP00000323659|ensembl:ENSP00000386516|ensembl:ENSP00000386660|uniprotkb:Q68UT9|uniprotkb:Q8IY08|uniprotkb:Q68D47|uniprotkb:Q53S72|uniprotkb:Q6N050|uniprotkb:D6W5M3 psi-mi:d0uzu1_hhv8(display_long)|uniprotkb:ORF73(gene name)|psi-mi:ORF73(display_short) psi-mi:kdm3a_human(display_long)|uniprotkb:KDM3A(gene name)|psi-mi:KDM3A(display_short)|uniprotkb:JHDM2A(gene name synonym)|uniprotkb:JMJD1(gene name synonym)|uniprotkb:JMJD1A(gene name synonym)|uniprotkb:KIAA0742(gene name synonym)|uniprotkb:TSGA(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 2A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 1A(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase 3A"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988832|imex:IM-26114-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0042025"(host cell nucleus)|interpro:IPR037007 ensembl:ENSG00000115548(gene)|ensembl:ENST00000312912(transcript)|ensembl:ENST00000409064(transcript)|ensembl:ENST00000409556(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0000785"(chromatin)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007290"(spermatid nucleus elongation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0036123"(histone H3-K9 dimethylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046293"(formaldehyde biosynthetic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|mint:Q9Y4C1|reactome:R-HSA-3214842|reactome:R-HSA-9029569|refseq:NP_001140160.1|refseq:NP_060903.2|refseq:XP_016859982.1|dip:DIP-53661N - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Cs4ZAazHA32axF9w/9qvLv+xjLI37296 rogid:XF6xqiiGohV0b2e/bzVx+J0XH7I9606 rigid:fwC0QvdNJJDFmb9Hii0ckA7LmEI false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q96BQ5 intact:EBI-14988878 intact:EBI-7219131|intact:MINT-1198594|ensembl:ENSP00000296824 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:cc127_human(display_long)|uniprotkb:CCDC127(gene name)|psi-mi:CCDC127(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:NP_660308.1|ensembl:ENST00000296824(transcript)|interpro:IPR034607|ensembl:ENSG00000164366(gene) - - comment:mint|comment:homomint figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:6g9aXdm9BxC971M1P45HmL4gFis9606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q96EE4 intact:EBI-14988878 intact:EBI-6448675|ensembl:ENSP00000304355|ensembl:ENSP00000386355|ensembl:ENSP00000386675|uniprotkb:Q75MQ6|uniprotkb:A8K1J6|uniprotkb:Q6UWP1 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:cc126_human(display_long)|uniprotkb:UNQ786/PRO1605(orf name)|uniprotkb:CCDC126(gene name)|psi-mi:CCDC126(display_short) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:XP_016868264.1|refseq:XP_016868265.1|ensembl:ENSG00000169193(gene)|ensembl:ENST00000409765(transcript)|ensembl:ENST00000410069(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|interpro:IPR027833|interpro:IPR042759|ensembl:ENST00000307471(transcript)|refseq:NP_620126.2 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:7MLBtoidrXgbvrTuetfnvZIC4a49606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q5UCC4 intact:EBI-14988878 intact:EBI-11284388|uniprotkb:Q5UCC6|uniprotkb:Q69YT5|uniprotkb:Q6UWP3|uniprotkb:Q86YL4|uniprotkb:Q8N541|ensembl:ENSP00000334037 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:emc10_human(display_long)|uniprotkb:EMC10(gene name)|psi-mi:EMC10(display_short)|uniprotkb:C19orf63(gene name synonym)|uniprotkb:Hematopoietic signal peptide-containing membrane domain-containing protein 1(gene name synonym)|uniprotkb:INM02(gene name synonym)|uniprotkb:UNQ764/PRO1556(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:NP_778233.4|refseq:NP_996261.1|ensembl:ENSG00000161671(gene)|ensembl:ENST00000334976(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005576"(extracellular region)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR029615|mint:Q5UCC4|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:NEJjkw5uEJnzNUW7MkZIm/ELpA89606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q10471 intact:EBI-14988878 intact:EBI-10226985|uniprotkb:A8K1Y3|uniprotkb:C5HU00|uniprotkb:Q9NPY4|uniprotkb:B7Z8V8|ensembl:ENSP00000355632 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:galt2_human(display_long)|uniprotkb:GALNT2(gene name)|psi-mi:GALNT2(display_short)|uniprotkb:Polypeptide GalNAc transferase 2(gene name synonym)|uniprotkb:Protein-UDP acetylgalactosaminyltransferase 2(gene name synonym)|uniprotkb:"UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2"(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:NP_001278795.1|refseq:NP_004472.1|ensembl:ENSG00000143641(gene)|ensembl:ENST00000366672(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004653"(polypeptide N-acetylgalactosaminyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0016020"(membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0018242"(protein O-linked glycosylation via serine)|go:"GO:0018243"(protein O-linked glycosylation via threonine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051604"(protein maturation)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001173(Glycosyl transferase, family 2)|interpro:IPR029044|interpro:IPR035992|rcsb pdb:2FFU|rcsb pdb:2FFV|rcsb pdb:4D0T|rcsb pdb:4D0Z|rcsb pdb:4D11|rcsb pdb:5AJN|rcsb pdb:5AJO|rcsb pdb:5AJP|rcsb pdb:5FV9|rcsb pdb:5NDF|rcsb pdb:6E7I|rcsb pdb:6EGS|rcsb pdb:6NQT|reactome:R-HSA-6811436|reactome:R-HSA-913709 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:z7hqeQjq7k5iQZfnLHZ4ioplKPU9606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q8TED1 intact:EBI-14988878 intact:EBI-11721746|ensembl:ENSP00000423822 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:gpx8_human(display_long)|uniprotkb:GPX8(gene name)|psi-mi:GPX8(display_short)|uniprotkb:UNQ847/PRO1785(orf name) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000164294(gene)|ensembl:ENST00000503787(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034599"(cellular response to oxidative stress)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR013376(Glutathione peroxidase Gpx7, putative)|interpro:IPR029760|interpro:IPR036249|rcsb pdb:3CYN|rcsb pdb:3KIJ|reactome:R-HSA-3299685|refseq:NP_001008398.2|refseq:NP_001293126.1|refseq:NP_001293127.1|refseq:NP_001293130.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:4Uu1pe2vaf0KS3mZyZJpSakdOvU9606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q09328 intact:EBI-14988878 intact:EBI-2864413|uniprotkb:D3DP70|ensembl:ENSP00000281923|ensembl:ENSP00000386377 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:mgt5a_human(display_long)|uniprotkb:MGAT5(gene name)|psi-mi:MGAT5(display_short)|uniprotkb:GGNT5(gene name synonym)|uniprotkb:GlcNAc-T V(gene name synonym)|uniprotkb:Mannoside acetylglucosaminyltransferase 5(gene name synonym)|uniprotkb:N-acetylglucosaminyl-transferase V(gene name synonym)|uniprotkb:Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase V(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:XP_011509501.1|refseq:XP_011509502.1|refseq:XP_011509503.1|refseq:XP_011509504.1|refseq:XP_006712597.1|refseq:NP_002401.1|refseq:XP_016859636.1|refseq:XP_016859637.1|refseq:XP_005263725.1|refseq:XP_005263726.1|refseq:XP_005263727.1|ensembl:ENSG00000152127(gene)|ensembl:ENST00000281923(transcript)|ensembl:ENST00000409645(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0019082"(viral protein processing)|go:"GO:0030144"(alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR026116|interpro:IPR027833|rcsb pdb:5ZIB|rcsb pdb:5ZIC|rcsb pdb:6YJQ|rcsb pdb:6YJR|rcsb pdb:6YJS|rcsb pdb:6YJT|rcsb pdb:6YJU|rcsb pdb:6YJV|reactome:R-HSA-9694548|reactome:R-HSA-975577 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:XPhy8p3/7Dwm1O2O9GBjKNc+p509606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q9NTJ5 intact:EBI-14988878 intact:EBI-3917235|uniprotkb:B4DK71|uniprotkb:Q7LA14|uniprotkb:A8K527|uniprotkb:Q96AX7|uniprotkb:Q9NQ46|uniprotkb:Q9NQ57|uniprotkb:O94935|uniprotkb:Q7LA22|ensembl:ENSP00000373713|ensembl:ENSP00000500361 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:sac1_human(display_long)|uniprotkb:SACM1L(gene name)|psi-mi:SACM1L(display_short)|uniprotkb:KIAA0851(gene name synonym)|uniprotkb:Suppressor of actin mutations 1-like protein(gene name synonym)|uniprotkb:Phosphatidylinositol-4-phosphate phosphatase(gene name synonym)|uniprotkb:SAC1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) refseq:XP_011531802.1|refseq:NP_054735.3|refseq:NP_001306001.1|refseq:NP_001306002.1|ensembl:ENSG00000211456(gene)|ensembl:ENST00000389061(transcript)|ensembl:ENST00000672477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034593"(phosphatidylinositol bisphosphate phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043812"(phosphatidylinositol-4-phosphate phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR002013(Synaptojanin, N-terminal)|reactome:R-HSA-1483248|reactome:R-HSA-1660514|go:"GO:0016791"(phosphatase activity) - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:aaI+D/4SJcwZxWqoxDJ81dA60nU9606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q76SF8 uniprotkb:Q99442 intact:EBI-14988878 intact:EBI-949221|ensembl:ENSP00000337688|ensembl:ENSP00000420331|uniprotkb:O00682|uniprotkb:O00729|intact:EBI-2689278|uniprotkb:D3DNQ0 psi-mi:q76sf8_hhv8(display_long)|uniprotkb:ORF74(gene name)|psi-mi:ORF74(display_short)|uniprotkb:HHV8GK18_gp84(orf name) psi-mi:sec62_human(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:TLOC1(gene name synonym)|uniprotkb:Translocation protein 1(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988876|imex:IM-26114-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_001129433.1|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0016021"(integral component of membrane) ensembl:ENSG00000008952(gene)|ensembl:ENST00000337002(transcript)|ensembl:ENST00000480708(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR004728(Translocation protein Sec62)|rcsb pdb:7BRT|refseq:NP_003253.1 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:SbNQsnFDrHs4uWgRUKgWEOCyQso37296 rogid:u7na6TjTcixVS+ZK2ygkFA1QDKY9606 rigid:tCjmUIOltMXGatMlCOX63jaWeAE false strep tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:O94766 uniprotkb:Q77UU3 intact:EBI-3917958|uniprotkb:B7ZAB3|uniprotkb:Q9UEP0|uniprotkb:Q96I06|ensembl:ENSP00000265471 intact:EBI-2608709|uniprotkb:Q2HRD1 psi-mi:b3ga3_human(display_long)|uniprotkb:B3GAT3(gene name)|psi-mi:B3GAT3(display_short)|uniprotkb:Beta-1,3-glucuronyltransferase 3(gene name synonym)|uniprotkb:Glucuronosyltransferase I(gene name synonym)|uniprotkb:"UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase"(gene name synonym) psi-mi:q77uu3_hhv8(display_long)|uniprotkb:ORF8(gene name)|psi-mi:ORF8(display_short)|uniprotkb:gB(gene name synonym) psi-mi:"MI:0400"(affinity technology) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14988898|imex:IM-26114-119 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275652.1|refseq:NP_036332.2|ensembl:ENSG00000149541(gene)|ensembl:ENST00000265471(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0015012"(heparan sulfate proteoglycan biosynthetic process)|go:"GO:0015018"(galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity)|go:"GO:0015020"(glucuronosyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050650"(chondroitin sulfate proteoglycan biosynthetic process)|go:"GO:0050651"(dermatan sulfate proteoglycan biosynthetic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0090316"(positive regulation of intracellular protein transport)|interpro:IPR005027(Glycosyl transferase, family 43)|interpro:IPR029044|mint:O94766|rcsb pdb:1FGG|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|rcsb pdb:3CU0|reactome:R-HSA-1971475|reactome:R-HSA-3560801|rcsb pdb:1KWS refseq:YP_001129354.1|interpro:IPR000234(Herpesvirus Glycoprotein B)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|interpro:IPR038631|interpro:IPR035377|interpro:IPR035381 - - - figure legend:1C and table S1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2017/04/13 2017/05/24 rogid:Yay8m8ZubBSmSoywX2Zk/dYNdzA9606 rogid:axqY9QAf9qDYK8QBWKDeC2G7V5c37296 rigid:r6uI5AOJlDXm6PZ3V2vaUdSY7Eg false - strep tag:c-c - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q15020 uniprotkb:F5HFL9 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-14032776 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:f5hfl9_hhv8(display_long)|uniprotkb:K4(gene name)|psi-mi:K4(display_short)|uniprotkb:HHV8GK18_gp13(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032774|imex:IM-26114-121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 go:"GO:0005576"(extracellular region)|go:"GO:0006955"(immune response)|go:"GO:0008009"(chemokine activity)|refseq:YP_001129362.1|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:La80rHFGoUDkFMcgOM0Y1/GKO/E37296 rigid:E2rI1jdP7u7lejq/Y1tfnFwrZOs false his tag:?-? strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q66LE6 uniprotkb:Q76S40 intact:EBI-717262|uniprotkb:A8KAK0|uniprotkb:Q5SQJ2|uniprotkb:Q9P1Y7|intact:EBI-2556023|ensembl:ENSP00000399970 intact:EBI-14032793 psi-mi:2abd_human(display_long)|uniprotkb:PP2A subunit B isoform delta(gene name synonym)|uniprotkb:PP2A subunit B isoform B55-delta(gene name synonym)|uniprotkb:PP2A subunit B isoform PR55-delta(gene name synonym)|uniprotkb:PPP2R2D(gene name)|psi-mi:PPP2R2D(display_short)|uniprotkb:KIAA1541(gene name synonym)|uniprotkb:PP2A subunit B isoform R2-delta(gene name synonym) psi-mi:q76s40_hhv8(display_long)|uniprotkb:ORF2(gene name)|psi-mi:ORF2(display_short)|uniprotkb:HHV8GK18_gp09(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14032791|imex:IM-26114-161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060931.2|ensembl:ENSG00000175470(gene)|ensembl:ENST00000455566(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005829"(cytosol)|go:"GO:0010458"(exit from mitosis)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0051301"(cell division)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|mint:Q66LE6|reactome:R-HSA-2465910|refseq:NP_001278239.1 go:"GO:0004146"(dihydrofolate reductase activity)|go:"GO:0006545"(glycine biosynthetic process)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0050661"(NADP binding)|interpro:IPR024072|interpro:IPR017925|interpro:IPR001796(Dihydrofolate reductase region)|interpro:IPR012259(Dihydrofolate reductase) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:rqczFHaYgyv+qEbwD4SjcdXrjR49606 rogid:H4OUZejGn3zNmZKHiT8JpvurDYw37296 rigid:e8VsfwqYlXvfHWso8/LtXbvP9ek false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P37198 uniprotkb:E5LBS6 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 intact:EBI-14033439 psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033437|imex:IM-26114-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N interpro:IPR006882(Herpesvirus ORF11 protein) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rigid:VStGBSyIW9zjJNwM6ibtafeqNrU false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P78406 uniprotkb:E5LBS6 intact:EBI-724495|uniprotkb:O15306|uniprotkb:Q3SYL7|uniprotkb:Q5TCH8|uniprotkb:Q6V708|uniprotkb:Q9H100|uniprotkb:Q9NQM6|ensembl:ENSP00000360286|ensembl:ENSP00000379181|ensembl:ENSP00000379182|uniprotkb:A8K882 intact:EBI-14033439 psi-mi:rae1l_human(display_long)|uniprotkb:mRNA-associated protein mrnp 41(gene name synonym)|uniprotkb:Rae1 protein homolog(gene name synonym)|uniprotkb:RAE1(gene name)|psi-mi:RAE1(display_short)|uniprotkb:MRNP41(gene name synonym) psi-mi:e5lbs6_hhv8(display_long)|uniprotkb:ORF10(gene name)|psi-mi:ORF10(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033446|imex:IM-26114-143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015885.1|refseq:NP_003601.1|ensembl:ENSG00000101146(gene)|ensembl:ENST00000371242(transcript)|ensembl:ENST00000395840(transcript)|ensembl:ENST00000395841(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037631|mint:P78406|rcsb pdb:3MMY|rcsb pdb:4OWR|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|interpro:IPR019775|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|refseq:XP_011527390.1|refseq:XP_011527391.1|refseq:XP_005260639.2|dip:DIP-41063N interpro:IPR006882(Herpesvirus ORF11 protein) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:JK4Y5p3WUcHFXBXyhhqCnDnG49c9606 rogid:O7Jf/HnbU1lSdY9z9Zcz8QeYars37296 rigid:WzxaVxS5B3XkZrA5UxUgyONotJs false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P52292 uniprotkb:E5LBT9 intact:EBI-349938|uniprotkb:Q9BRU5|ensembl:ENSP00000504685|intact:EBI-28977049|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|uniprotkb:B9EJD6|uniprotkb:Q53YE3|intact:EBI-9377406|uniprotkb:Q6NVW7 intact:EBI-14033452 psi-mi:ima1_human(display_long)|uniprotkb:KPNA2(gene name)|psi-mi:KPNA2(display_short)|uniprotkb:RCH1(gene name synonym)|uniprotkb:SRP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym) psi-mi:e5lbt9_hhv8(display_long)|uniprotkb:ORF17(gene name)|psi-mi:ORF17(display_short)|uniprotkb:Protease precursor(gene name synonym)|uniprotkb:HHV8GK18_gp20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033450|imex:IM-26114-163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002257.1|refseq:NP_001307540.1|ensembl:ENST00000330459(transcript)|ensembl:ENST00000537025(transcript)|ensembl:ENST00000579754(transcript)|ensembl:ENST00000584026(transcript)|ensembl:ENST00000677086(transcript)|ensembl:ENST00000679078(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52292|rcsb pdb:1EFX|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:3FEX|ensembl:ENSG00000182481(gene)|rcsb pdb:3FEY|rcsb pdb:3WPT|rcsb pdb:4E4V|rcsb pdb:4WV6|rcsb pdb:5H43|rcsb pdb:7N8J|reactome:R-HSA-111932|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-442729|reactome:R-HSA-5693548|reactome:R-HSA-9018519|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|ensembl:ENSP00000504685|dip:DIP-6205N refseq:YP_001129369.1|interpro:IPR001847(Peptidase S21, herpesvirus maturational proteinase, assemblin)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|interpro:IPR035443 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:DFtAbvPxkzWJO/fRLPGxA6pEEJQ9606 rogid:Of3tIEudu+LFkQ/IeHO4+MWOHk837296 rigid:sRTQW9hIyiN6RfepNvSu8XlK1b0 false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y5X1 uniprotkb:Q98143 intact:EBI-77848|ensembl:ENSP00000376024|ensembl:ENSP00000506326|uniprotkb:Q9BSI7|uniprotkb:Q9BVM1|uniprotkb:Q9UJH6|uniprotkb:Q9UP20 intact:EBI-2608563|intact:EBI-2644289|uniprotkb:Q2HRB1 psi-mi:snx9_human(display_long)|uniprotkb:SNX9(gene name)|psi-mi:SNX9(display_short)|uniprotkb:SH3PX1(gene name synonym)|uniprotkb:SH3PXD3A(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 3A(gene name synonym) psi-mi:q98143_hhv8(display_long)|uniprotkb:ORF21(gene name)|psi-mi:ORF21(display_short)|uniprotkb:TK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033461|imex:IM-26114-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000130340(gene)|ensembl:ENST00000392185(transcript)|ensembl:ENST00000679814(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097320"(plasma membrane tubulation)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR014536(Sorting nexin, Snx9 type)|interpro:IPR019497|interpro:IPR027267|interpro:IPR028644|interpro:IPR035558|interpro:IPR036028|interpro:IPR036871|interpro:IPR037425|interpro:IPR037426|mint:Q9Y5X1|rcsb pdb:2RAI|rcsb pdb:2RAJ|rcsb pdb:2RAK|rcsb pdb:3DYT|rcsb pdb:3DYU|rcsb pdb:3LGE|reactome:R-HSA-432722|reactome:R-HSA-8856828|refseq:NP_057308.1|dip:DIP-30997N interpro:IPR001889(Herpesvirus thymidine kinase)|interpro:IPR013672(Herpesvirus thymidine kinase, C-terminal)|refseq:YP_001129374.1|go:"GO:0004797"(thymidine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006230"(TMP biosynthetic process)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR027417 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:qtqmMew2psrK6OJPAOWQGTVmNJA9606 rogid:TGnKxwKUPOAfJGfFqZ/2tgltMxY37296 rigid:89yyYwRV0XRvm1fHTW2MAJZzxVM false his tag:n-n strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62136 uniprotkb:Q76TK5 intact:EBI-357253|uniprotkb:P08129|uniprotkb:P20653|uniprotkb:P22802|uniprotkb:B2R908|intact:EBI-2623163|uniprotkb:Q07161|intact:EBI-2556927|uniprotkb:A6NNR3|ensembl:ENSP00000365936 intact:EBI-14033469|uniprotkb:Q2HRA9 psi-mi:pp1a_human(display_long)|uniprotkb:PPP1CA(gene name)|psi-mi:PPP1CA(display_short)|uniprotkb:PPP1A(gene name synonym) psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033467|imex:IM-26114-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008709.1|refseq:NP_002699.1|refseq:NP_996756.1|dip:DIP-221N|dip:DIP-38195N|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0036496"(regulation of translational initiation by eIF2 alpha dephosphorylation)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0046872"(metal ion binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051301"(cell division)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037979|mint:P62136|rcsb pdb:3E7A|rcsb pdb:3E7B|rcsb pdb:3EGG|rcsb pdb:3EGH|rcsb pdb:3HVQ|rcsb pdb:3N5U|rcsb pdb:3V4Y|rcsb pdb:4G9J|rcsb pdb:4MOV|rcsb pdb:4MOY|rcsb pdb:4MP0|rcsb pdb:4XPN|rcsb pdb:5IOH|rcsb pdb:6ALZ|rcsb pdb:6CZO|rcsb pdb:6DCX|rcsb pdb:6DNO|rcsb pdb:6G0I|rcsb pdb:6G0J|rcsb pdb:6GHM|rcsb pdb:6OBN|rcsb pdb:6OBP|rcsb pdb:6OBQ|rcsb pdb:6OBR|rcsb pdb:6OBS|rcsb pdb:6OBU|rcsb pdb:6ZEE|rcsb pdb:6ZEF|rcsb pdb:6ZEG|rcsb pdb:6ZEH|rcsb pdb:6ZEI|rcsb pdb:6ZEJ|rcsb pdb:6ZK6|reactome:R-HSA-163560|reactome:R-HSA-180024|reactome:R-HSA-2173788|reactome:R-HSA-400253|go:"GO:0098793"(presynapse)|ensembl:ENSG00000172531(gene)|ensembl:ENST00000376745(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0030324"(lung development) refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:IMypaKng+5AECbCd3N72pgzUlxQ9606 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rigid:fXRp88pSTRNxIlMXmwWRw/NJAMQ false flag tag:n-n strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P62140 uniprotkb:Q76TK5 intact:EBI-352350|uniprotkb:P37140|uniprotkb:Q5U087|uniprotkb:Q6FG45|uniprotkb:D6W565|uniprotkb:B2R5V4|ensembl:ENSP00000296122|ensembl:ENSP00000351298|ensembl:ENSP00000378769 intact:EBI-14033469|uniprotkb:Q2HRA9 psi-mi:pp1b_human(display_long)|uniprotkb:PPP1CB(gene name)|psi-mi:PPP1CB(display_short) psi-mi:q76tk5_hhv8(display_long)|uniprotkb:ORF23(gene name)|psi-mi:ORF23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033480|imex:IM-26114-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002700.1|refseq:NP_996759.1|ensembl:ENSG00000213639(gene)|ensembl:ENST00000296122(transcript)|ensembl:ENST00000358506(transcript)|ensembl:ENST00000395366(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|mint:P62140|reactome:R-HSA-163560|reactome:R-HSA-2173788|reactome:R-HSA-2565942|reactome:R-HSA-400253|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5673000|reactome:R-HSA-9660537|dip:DIP-33220N refseq:YP_001129376.1|interpro:IPR006772(Herpesvirus BTRF1 protein) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:VtNJVyimeiEuRDDWtGswTqoSOH89606 rogid:p23HuLkwroVJTdSrNqj3HG0yO3437296 rigid:6YxlopneOZZEgHGNaQU0YemqCiU false flag tag:n-n strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q98140 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-14033488|uniprotkb:Q2HRA8 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033486|imex:IM-26114-145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rigid:zgMCY1RhwuGtjR6/suhqjDcUkps false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H6T3 uniprotkb:Q98140 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-14033488|uniprotkb:Q2HRA8 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:q98140_hhv8(display_long)|uniprotkb:ORF24(gene name)|psi-mi:ORF24(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033497|imex:IM-26114-147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK refseq:YP_001129377.1|interpro:IPR004285(Herpesvirus UL87) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:qZ5tOoqJbflx+h75XBQMQ4uYv7M37296 rigid:chZqsCGnEtL6/EjOueY6j3mxcuk false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14773 uniprotkb:E5LBV4 intact:EBI-2800203|uniprotkb:Q5JAK6|uniprotkb:Q6UX56|uniprotkb:Q96C37|uniprotkb:Q71JP6|uniprotkb:Q53HT1|ensembl:ENSP00000299427 intact:EBI-14033503 psi-mi:tpp1_human(display_long)|uniprotkb:CLN2(gene name synonym)|uniprotkb:Tripeptidyl-peptidase I(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)|uniprotkb:Lysosomal pepstatin-insensitive protease(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 1 protein(gene name synonym)|uniprotkb:GIG1(orf name)|uniprotkb:UNQ267/PRO304(orf name)|uniprotkb:TPP1(gene name)|psi-mi:TPP1(display_short) psi-mi:e5lbv4_hhv8(display_long)|uniprotkb:ORF31(gene name)|psi-mi:ORF31(display_short)|uniprotkb:HHV8GK18_gp35(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033501|imex:IM-26114-123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000382.3|ensembl:ENSG00000166340(gene)|ensembl:ENST00000299427(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0120146"(sulfatide binding)|go:"GO:1905146"(lysosomal protein catabolic process)|interpro:IPR015366(Peptidase S53, propeptide)|interpro:IPR030400|interpro:IPR036852|mint:O14773|rcsb pdb:1R60|rcsb pdb:3EDY|rcsb pdb:3EE6|reactome:R-HSA-381038|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|dip:DIP-47434N refseq:YP_001129384.1|interpro:IPR004289(UL92) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:lhbu2VS1TqFCwSf8XBd6U17K1sU9606 rogid:3mHxrPCiwxgtKW1jMQda7pbTPpw37296 rigid:2FsQWqfAeHHFu9qDYU8HnOs3m7o false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P50897 uniprotkb:Q76RH3 intact:EBI-1237011|intact:EBI-2859371|uniprotkb:Q6FGQ4|uniprotkb:B4DY24|ensembl:ENSP00000432053|ensembl:ENSP00000493153 intact:EBI-14033513|uniprotkb:Q2HR94 psi-mi:ppt1_human(display_long)|uniprotkb:PPT1(gene name)|psi-mi:PPT1(display_short)|uniprotkb:PPT(gene name synonym)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:CLN1(gene name synonym) psi-mi:q76rh3_hhv8(display_long)|uniprotkb:ORF38(gene name)|psi-mi:ORF38(display_short)|uniprotkb:HHV8GK18_gp42(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033511|imex:IM-26114-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000301.1|refseq:NP_001136076.1|ensembl:ENSG00000131238(gene)|ensembl:ENST00000529905(transcript)|ensembl:ENST00000642050(transcript)|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006907"(pinocytosis)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050896"(response to stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|mint:P50897|rcsb pdb:3GRO|reactome:R-HSA-75105|go:"GO:0043524"(negative regulation of neuron apoptotic process) refseq:YP_001129391.1|interpro:IPR024360|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:2G1ae6m4OZsMiRzro/2JmWiOOMA9606 rogid:dh29vvUWN2rI7Fp5/5JsYg8ZfJM37296 rigid:PUeP5wfweu0aJo+lUWXk7T35N1Y false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P46108 uniprotkb:O40931 intact:EBI-886|uniprotkb:B0LPE8|uniprotkb:Q96HJ0|uniprotkb:A8MWE8|uniprotkb:Q96GA9|uniprotkb:D3DTH6|intact:EBI-28974221|ensembl:ENSP00000300574|intact:EBI-16429791 intact:EBI-2608673|uniprotkb:Q2HR93 psi-mi:crk_human(display_long)|uniprotkb:Proto-oncogene c-Crk(gene name synonym)|uniprotkb:CRK(gene name)|psi-mi:CRK(display_short)|uniprotkb:p38(gene name synonym) psi-mi:o40931_hhv8(display_long)|uniprotkb:ORF39(gene name)|psi-mi:ORF39(display_short)|uniprotkb:gM(gene name synonym)|uniprotkb:HHV8GK18_gp43(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033522|imex:IM-26114-125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000300574|ensembl:ENST00000398970|ensembl:ENSP00000381942|refseq:NP_005197.3|refseq:NP_058431.2|ensembl:ENSG00000167193(gene)|ensembl:ENST00000300574(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|dip:DIP-199N|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990859"(cellular response to endothelin)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46108|rcsb pdb:1JU5|rcsb pdb:2DVJ|rcsb pdb:2EYV|rcsb pdb:2EYW|rcsb pdb:2EYX|rcsb pdb:2EYY|rcsb pdb:2EYZ|rcsb pdb:2MS4|rcsb pdb:5UL6|rcsb pdb:6ATV|reactome:R-HSA-170984|reactome:R-HSA-186763|reactome:R-HSA-2029482|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-912631|reactome:R-HSA-9664422 interpro:IPR000785(Herpsevirus integral membrane protein)|refseq:YP_001129392.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0044201"(host cell nuclear inner membrane)|go:"GO:0055036"(virion membrane) - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:lIXCzFxFvmvsfPaLQIKV9QS75cw9606 rogid:67bpFNnadSqtGImtvPWws2me1BI37296 rigid:wwuxl/SK4tWKECTafyrr7DUfJTk false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P26358 uniprotkb:Q77UV9 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 intact:EBI-2608731|uniprotkb:Q2HR88 psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033526|imex:IM-26114-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N refseq:YP_001129397.1 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rigid:XcTeVreLvROde23uljHCFfmXSfk false ha tag:n-n strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15014 uniprotkb:Q77UV9 intact:EBI-399257|uniprotkb:B3KP92|uniprotkb:Q567V0|uniprotkb:Q8J026|uniprotkb:D3DXA5|ensembl:ENSP00000353643|ensembl:ENSP00000391969|ensembl:ENSP00000410532|ensembl:ENSP00000415476 intact:EBI-2608731|uniprotkb:Q2HR88 psi-mi:mo4l2_human(display_long)|uniprotkb:MORF4L2(gene name)|psi-mi:MORF4L2(display_short)|uniprotkb:KIAA0026(gene name synonym)|uniprotkb:MRGX(gene name synonym)|uniprotkb:MORF-related gene X protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRGX(gene name synonym)|uniprotkb:Protein MSL3-2(gene name synonym) psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033532|imex:IM-26114-127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135894.1|refseq:NP_001135895.1|refseq:NP_001135896.1|refseq:NP_001135897.1|refseq:NP_001135898.1|refseq:NP_001135899.1|refseq:NP_001135900.1|refseq:NP_001135901.1|refseq:NP_001135902.1|refseq:NP_001135903.1|refseq:NP_001135904.1|refseq:NP_036418.1|refseq:NP_001135890.1|refseq:NP_001135891.1|refseq:NP_001135892.1|refseq:NP_001135893.1|ensembl:ENSG00000123562(gene)|ensembl:ENST00000360458(transcript)|ensembl:ENST00000433176(transcript)|ensembl:ENST00000441076(transcript)|ensembl:ENST00000451301(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR008676(MRG)|interpro:IPR026541|interpro:IPR038012|interpro:IPR038217|mint:Q15014|reactome:R-HSA-3214847 refseq:YP_001129397.1 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:7SlnJWNVhfdzirTHBEseWbJQjyU9606 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rigid:G2+jzfndgNAmdpH0KC4UFVcmSQs false - strep tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q93009 uniprotkb:Q77UV9 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2608731|uniprotkb:Q2HR88 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:q77uv9_hhv8(display_long)|uniprotkb:ORF45(gene name synonym)|uniprotkb:KIE-2(gene name)|psi-mi:KIE-2(display_short)|uniprotkb:HHV8GK18_gp51(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Davis et al. (2015) pubmed:25544563|imex:IM-26114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:37296(hhv8)|taxid:37296("Human herpesvirus 8 (HHV-8)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-14033538|imex:IM-26114-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:YP_001129397.1 - - - figure legend:table s1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/04/13 2017/04/20 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:+FTLxICWpR0MoWtF7Li12SuSZ+w37296 rigid:YnozeyPjEtA+RmEdvNKCqYtOmxE false myc tag:?-? c-venus:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)