#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O43157-1 uniprotkb:Q92730 intact:EBI-15880891|ensembl:ENSP00000296440|ensembl:ENSP00000351338 intact:EBI-448618|uniprotkb:A8K9P7|ensembl:ENSP00000308461 psi-mi:o43157-1(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:PLXN5(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym) psi-mi:rnd1_human(display_long)|uniprotkb:RND1(gene name)|psi-mi:RND1(display_short)|uniprotkb:RHO6(gene name synonym)|uniprotkb:Rho family GTPase 1(gene name synonym)|uniprotkb:Rnd1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Okada et al. (2015) pubmed:25531777|doi:10.1038/ncb3082|imex:IM-24444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16135298|imex:IM-24444-1|dip:DIP-65260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164050(gene)|ensembl:ENST00000358536(transcript)|ensembl:ENST00000296440(transcript)|intact:EBI-1111488(isoform-parent) refseq:NP_055285.1|dip:DIP-36741N|ensembl:ENSG00000172602(gene)|ensembl:ENST00000309739(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2CLS|rcsb pdb:2REX|rcsb pdb:3Q3J|reactome:R-HSA-399955|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-9696273 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606 rogid:phz3xjUx3hNvqd/BE+e6Zjb2n7g9606 rigid:qK64kTqrAxfMYsIWl9Xa4Fm2EkE false vsv tag:n-n mutation disrupting interaction strength:45-45|mutation disrupting interaction strength:48-48|flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NYB0 uniprotkb:P20936 intact:EBI-750109|uniprotkb:B4DQN4|uniprotkb:Q4W4Y2|uniprotkb:Q8WYZ3|uniprotkb:Q9NWR2|ensembl:ENSP00000300086 intact:EBI-1026476|uniprotkb:B2R6W3|uniprotkb:Q9UDI1|uniprotkb:B4DTL2|uniprotkb:Q68CU6|ensembl:ENSP00000274376 psi-mi:te2ip_human(display_long)|uniprotkb:DRIP5(gene name synonym)|uniprotkb:TERF2IP(gene name)|psi-mi:TERF2IP(display_short)|uniprotkb:RAP1(gene name synonym)|uniprotkb:PP8000(orf name)|uniprotkb:Dopamine receptor-interacting protein 5(gene name synonym)|uniprotkb:Repressor/activator protein 1 homolog(gene name synonym) psi-mi:rasa1_human(display_long)|uniprotkb:Ras p21 protein activator(gene name synonym)|uniprotkb:p120GAP(gene name synonym)|uniprotkb:RASA1(gene name)|psi-mi:RASA1(display_short)|uniprotkb:RASA(gene name synonym)|uniprotkb:GAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Okada et al. (2015) pubmed:25531777|doi:10.1038/ncb3082|imex:IM-24444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16135325|imex:IM-24444-2|dip:DIP-199163E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000300086(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000166848(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016604"(nuclear body)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|refseq:NP_061848.2|dip:DIP-34868N|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0048239"(negative regulation of DNA recombination at telomere)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR001357(BRCT)|interpro:IPR009057(Homeodomain-like)|interpro:IPR015010(Rap1 Myb)|interpro:IPR021661|interpro:IPR036420|interpro:IPR038104|interpro:IPR039595|mint:Q9NYB0|rcsb pdb:1FEX|rcsb pdb:3K6G|rcsb pdb:4RQI|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095 refseq:NP_002881.1|refseq:NP_072179.1|ensembl:ENSG00000145715(gene)|ensembl:ENST00000274376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051020"(GTPase binding)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023152|interpro:IPR028554|interpro:IPR035652|interpro:IPR035841|interpro:IPR035842|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|interpro:IPR039360|mint:P20936|rcsb pdb:1WER|rcsb pdb:1WQ1|rcsb pdb:2GQI|rcsb pdb:2GSB|rcsb pdb:2J05|rcsb pdb:2J06|rcsb pdb:2M51|rcsb pdb:4FSS|rcsb pdb:6PXB|rcsb pdb:6PXC|rcsb pdb:6WAX|rcsb pdb:6WAY|reactome:R-HSA-186763|reactome:R-HSA-3928662|reactome:R-HSA-5218921|reactome:R-HSA-5658442|reactome:R-HSA-8849471|ensembl:ENSP00000274376|ensembl:ENST00000456692|ensembl:ENSP00000411221|ensembl:ENST00000512763|ensembl:ENSP00000422008|ensembl:ENST00000515800|ensembl:ENSP00000423395|dip:DIP-144N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:rH6GKcTfjxpXw0MAcOHQk29nz+09606 rogid:XmAfxJhh+X9qLWYH5F3pOlVdIGU9606 rigid:B/0S5wO/ypSnqwIBiKUi6JgcQjo false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43157-1 uniprotkb:Q92730 intact:EBI-15880891|ensembl:ENSP00000296440|ensembl:ENSP00000351338 intact:EBI-448618|uniprotkb:A8K9P7|ensembl:ENSP00000308461 psi-mi:o43157-1(display_long)|uniprotkb:PLXNB1(gene name)|psi-mi:PLXNB1(display_short)|uniprotkb:KIAA0407(gene name synonym)|uniprotkb:PLXN5(gene name synonym)|uniprotkb:SEP(gene name synonym)|uniprotkb:Semaphorin receptor SEP(gene name synonym) psi-mi:rnd1_human(display_long)|uniprotkb:RND1(gene name)|psi-mi:RND1(display_short)|uniprotkb:RHO6(gene name synonym)|uniprotkb:Rho family GTPase 1(gene name synonym)|uniprotkb:Rnd1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Okada et al. (2015) pubmed:25531777|doi:10.1038/ncb3082|imex:IM-24444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16135346|imex:IM-24444-3|dip:DIP-65260E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164050(gene)|ensembl:ENST00000358536(transcript)|ensembl:ENST00000296440(transcript)|intact:EBI-1111488(isoform-parent) refseq:NP_055285.1|dip:DIP-36741N|ensembl:ENSG00000172602(gene)|ensembl:ENST00000309739(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2CLS|rcsb pdb:2REX|rcsb pdb:3Q3J|reactome:R-HSA-399955|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-9696273 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:wWC3lipQ3PIBCvCjt5t2gQTAXro9606 rogid:phz3xjUx3hNvqd/BE+e6Zjb2n7g9606 rigid:qK64kTqrAxfMYsIWl9Xa4Fm2EkE false vsv tag:n-n mutation disrupting interaction strength:70-70|mutation disrupting interaction strength:98-98|myc tag:n-n|mutation disrupting interaction strength:180-180 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NRY4 uniprotkb:Q92730 intact:EBI-766200|uniprotkb:Q14452|uniprotkb:Q9C0E1|uniprotkb:A7E2A4|ensembl:ENSP00000385720|ensembl:ENSP00000483730|ensembl:ENSP00000500409 intact:EBI-448618|uniprotkb:A8K9P7|ensembl:ENSP00000308461 psi-mi:rhg35_human(display_long)|uniprotkb:Glucocorticoid receptor repression factor 1(gene name synonym)|uniprotkb:Rho GAP p190A(gene name synonym)|uniprotkb:Glucocorticoid receptor DNA-binding factor 1(gene name synonym)|uniprotkb:GRF1(gene name synonym)|uniprotkb:KIAA1722(gene name synonym)|uniprotkb:ARHGAP35(gene name)|psi-mi:ARHGAP35(display_short)|uniprotkb:GRLF1(gene name synonym)|uniprotkb:P190A(gene name synonym)|uniprotkb:p190ARHOGAP(gene name synonym) psi-mi:rnd1_human(display_long)|uniprotkb:RND1(gene name)|psi-mi:RND1(display_short)|uniprotkb:RHO6(gene name synonym)|uniprotkb:Rho family GTPase 1(gene name synonym)|uniprotkb:Rnd1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Okada et al. (2015) pubmed:25531777|doi:10.1038/ncb3082|imex:IM-24444 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16135376|imex:IM-24444-4|dip:DIP-199162E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004482.4|refseq:XP_016882203.1|dip:DIP-34578N|ensembl:ENSG00000160007(gene)|ensembl:ENST00000404338(transcript)|ensembl:ENST00000614079(transcript)|ensembl:ENST00000672722(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003677"(DNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030879"(mammary gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0097485"(neuron projection guidance)|interpro:IPR000198(RhoGAP)|interpro:IPR001806(Ras GTPase)|interpro:IPR002713(FF)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR027417|interpro:IPR032835|interpro:IPR036517|interpro:IPR039006|interpro:IPR039007|rcsb pdb:2K85|rcsb pdb:3C5H|rcsb pdb:3FK2|rcsb pdb:6PXC|rcsb pdb:6WAY|reactome:R-HSA-416550|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 refseq:NP_055285.1|dip:DIP-36741N|ensembl:ENSG00000172602(gene)|ensembl:ENST00000309739(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:2CLS|rcsb pdb:2REX|rcsb pdb:3Q3J|reactome:R-HSA-399955|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-9696273 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/08 2017/08/10 rogid:QvhQwcov1A+SZ0qmVnhVebJ30rg9606 rogid:phz3xjUx3hNvqd/BE+e6Zjb2n7g9606 rigid:BCqN4luoRkbWvWRJ4+1fmvVUsEM false ha tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)