#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75140-10	uniprotkb:Q12980	intact:EBI-16126218|ensembl:ENSP00000371546|ensembl:ENSP00000498382	intact:EBI-2650314|uniprotkb:Q1W6H0|uniprotkb:Q4TT56|uniprotkb:Q92469|uniprotkb:D3DU40|ensembl:ENSP00000478273	psi-mi:o75140-10(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:nprl3_human(display_long)|uniprotkb:MARE(gene name synonym)|uniprotkb:NPRL3(gene name)|psi-mi:NPRL3(display_short)|uniprotkb:C16orf35(gene name synonym)|uniprotkb:CGTHBA(gene name synonym)|uniprotkb:Alpha-globin regulatory element-containing gene protein(gene name synonym)|uniprotkb:Protein CGTHBA(gene name synonym)|uniprotkb:-14 gene protein(gene name synonym)|uniprotkb:Nitrogen permease regulator 3-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	van et al. (2015)	pubmed:25366275|doi:10.1002/humu.22723|imex:IM-25465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126226|imex:IM-25465-1|dip:DIP-201211E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_001070818.1|ensembl:ENSG00000103148(gene)|ensembl:ENST00000611875(transcript)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060021"(roof of mouth development)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR005365(Protein of unknown function UPF0171)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|dip:DIP-62051N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606	rogid:SesntEp9nxFuoCGuZ06jHWqueek9606	rigid:mAwdD6nWv2zrHuTmjHudiTRfmrM	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75140-10	uniprotkb:Q8WTW4	intact:EBI-16126218|ensembl:ENSP00000371546|ensembl:ENSP00000498382	intact:EBI-1043552|uniprotkb:Q9Y249|uniprotkb:Q9Y497|ensembl:ENSP00000232501|uniprotkb:A8K831|uniprotkb:Q6FGS2	psi-mi:o75140-10(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:nprl2_human(display_long)|uniprotkb:NPRL2(gene name)|psi-mi:NPRL2(display_short)|uniprotkb:Gene 21 protein(gene name synonym)|uniprotkb:TUSC4(gene name synonym)|uniprotkb:Tumor suppressor candidate 4(gene name synonym)|uniprotkb:Nitrogen permease regulator 2-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	van et al. (2015)	pubmed:25366275|doi:10.1002/humu.22723|imex:IM-25465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126226|imex:IM-25465-1|dip:DIP-201211E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|intact:EBI-11102814(isoform-parent)	ensembl:ENSG00000114388(gene)|ensembl:ENST00000232501(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:1990130"(GATOR1 complex)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR009348(Nitrogen permease regulator 2)|rcsb pdb:6CES|rcsb pdb:6CET|reactome:R-HSA-9639288|refseq:NP_006536.3|dip:DIP-50746N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606	rogid:SisXpfhPK3ANV4KYGsNgfxhWDa89606	rigid:mAwdD6nWv2zrHuTmjHudiTRfmrM	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75140-10	uniprotkb:Q9HB90	intact:EBI-16126218|ensembl:ENSP00000371546|ensembl:ENSP00000498382	intact:EBI-752390|uniprotkb:Q9H202|uniprotkb:Q9H8Q8|ensembl:ENSP00000362092	psi-mi:o75140-10(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:rragc_human(display_long)|uniprotkb:GTPase-interacting protein 2(gene name synonym)|uniprotkb:TIB929(gene name synonym)|uniprotkb:RRAGC(gene name)|psi-mi:RRAGC(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	van et al. (2015)	pubmed:25366275|doi:10.1002/humu.22723|imex:IM-25465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126252|imex:IM-25465-2|dip:DIP-201212E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_071440.1|refseq:NP_001258780.1|dip:DIP-37515N|ensembl:ENSG00000116954(gene)|ensembl:ENST00000373001(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1903432"(regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039400|rcsb pdb:3LLU|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6A|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606	rogid:5Wh3WajmqgjOUv7dyJZ8ZfRGljk9606	rigid:v4ZronU00jcctKx+NvyHxVBj4xo	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75140-10	uniprotkb:Q7L523	intact:EBI-16126218|ensembl:ENSP00000371546|ensembl:ENSP00000498382	intact:EBI-752376|uniprotkb:O00290|uniprotkb:Q15347|uniprotkb:B2R7L1|ensembl:ENSP00000369899	psi-mi:o75140-10(display_long)|uniprotkb:DEPDC5(gene name)|psi-mi:DEPDC5(display_short)|uniprotkb:KIAA0645(gene name synonym)|uniprotkb:DEP domain-containing protein 5(gene name synonym)	psi-mi:rraga_human(display_long)|uniprotkb:Adenovirus E3 14.7 kDa-interacting protein 1(gene name synonym)|uniprotkb:FIP-1(gene name synonym)|uniprotkb:RRAGA(gene name)|psi-mi:RRAGA(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	van et al. (2015)	pubmed:25366275|doi:10.1002/humu.22723|imex:IM-25465	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126252|imex:IM-25465-2|dip:DIP-201212E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100150(gene)|ensembl:ENST00000382112(transcript)|ensembl:ENST00000651528(transcript)|intact:EBI-11102814(isoform-parent)	refseq:NP_006561.1|dip:DIP-37516N|rcsb pdb:6S6A|ensembl:ENSG00000155876(gene)|ensembl:ENST00000380527(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008219"(cell death)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990131"(Gtr1-Gtr2 GTPase complex)|interpro:IPR006762(Gtr1/RagA G protein)|interpro:IPR027417|interpro:IPR039397|rcsb pdb:5X6V|rcsb pdb:6CES|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6S6D|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6U62|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8866654|reactome:R-HSA-8943724|reactome:R-HSA-9639288	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:V209SbgYwn96oWnCN3HlAx7Ewfo9606	rogid:1BxTVycwXop9+lViwQU5TyK/tlI9606	rigid:v4ZronU00jcctKx+NvyHxVBj4xo	false	flag tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)