#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P13688	uniprotkb:Q8TDQ0	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126022|imex:IM-24319-2|dip:DIP-198907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rigid:vdg2gSmNbBliP6q6og6NywbHAPk	false	flag tag:n-n|mutation decreasing interaction strength:123-123|mutation decreasing interaction strength:78-78|mutation disrupting interaction strength:81-81|mutation decreasing interaction strength:76-76	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z1R2	uniprotkb:Q8VIM0	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126005|imex:IM-24319-1|dip:DIP-198906E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/08	2017/08/10	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rigid:7PH7v3lmKcbQml3kb0WwFVzcH7c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13688	uniprotkb:Q8TDQ0	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126055|imex:IM-24319-3|dip:DIP-198907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rigid:vdg2gSmNbBliP6q6og6NywbHAPk	false	flag tag:n-n	sufficient binding region:1-105|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13688	uniprotkb:Q8TDQ0	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126095|imex:IM-24319-5|dip:DIP-198907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rigid:vdg2gSmNbBliP6q6og6NywbHAPk	false	flag tag:n-n	ha tag:n-n|mutation decreasing interaction strength:62-62|mutation decreasing interaction strength:111-111|mutation decreasing interaction strength:58-58|mutation decreasing interaction strength:110-110|mutation decreasing interaction strength:109-109	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13688	uniprotkb:Q8TDQ0	intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559	intact:EBI-11472922|uniprotkb:B2RAY2|uniprotkb:Q8WW60|uniprotkb:Q96K94|ensembl:ENSP00000312002	psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)	psi-mi:havr2_human(display_long)|uniprotkb:HAVCR2(gene name)|psi-mi:HAVCR2(display_short)|uniprotkb:TIM3(gene name synonym)|uniprotkb:TIMD3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126078|imex:IM-24319-4|dip:DIP-198907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N	refseq:NP_116171.3|ensembl:ENSG00000135077(gene)|ensembl:ENST00000307851(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005769"(early endosome)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5DZL|rcsb pdb:5F71|rcsb pdb:6DHB|rcsb pdb:6TXZ|reactome:R-HSA-451927|dip:DIP-61459N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606	rogid:OodjoYcoXmfSCAmfINtl85mgyAs9606	rigid:vdg2gSmNbBliP6q6og6NywbHAPk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P31809	uniprotkb:Q8VIM0	intact:EBI-8663470|uniprotkb:Q61350|uniprotkb:Q61353|intact:MINT-4590618	intact:EBI-6665112|ensembl:ENSMUSP00000020668	psi-mi:ceam1_mouse(display_long)|uniprotkb:Ceacam1(gene name)|psi-mi:Ceacam1(display_short)|uniprotkb:Bgp(gene name synonym)|uniprotkb:Bgp1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)|uniprotkb:Murine hepatitis virus receptor(gene name synonym)|uniprotkb:MHVR1(gene name synonym)|uniprotkb:Biliary glycoprotein D(gene name synonym)	psi-mi:havr2_mouse(display_long)|uniprotkb:Havcr2(gene name)|psi-mi:Havcr2(display_short)|uniprotkb:Tim3(gene name synonym)|uniprotkb:Timd3(gene name synonym)|uniprotkb:T-cell immunoglobulin and mucin domain-containing protein 3(gene name synonym)|uniprotkb:T-cell membrane protein 3(gene name synonym)|uniprotkb:T-cell immunoglobulin mucin receptor 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2015)	pubmed:25363763|doi:10.1038/nature13848|imex:IM-24319	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16126131|imex:IM-24319-6|dip:DIP-198908E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005130"(granulocyte colony-stimulating factor receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031005"(filamin binding)|go:"GO:0031528"(microvillus membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0030054"(cell junction)|go:"GO:0030133"(transport vesicle)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1L6Z|rcsb pdb:3R4D|rcsb pdb:5VST|rcsb pdb:6VSJ|interpro:IPR036179|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-6798695|refseq:NP_001034274.1|refseq:NP_001034275.1|dip:DIP-61461N	ensembl:ENSMUSG00000020399(gene)|ensembl:ENSMUST00000020668(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002652"(regulation of tolerance induction dependent upon immune response)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002838"(negative regulation of immune response to tumor cell)|go:"GO:0005576"(extracellular region)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0032712"(negative regulation of interleukin-3 production)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071656"(negative regulation of granulocyte colony-stimulating factor production)|go:"GO:1900425"(negative regulation of defense response to bacterium)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KAA|go:"GO:0045087"(innate immune response)|go:"GO:0043032"(positive regulation of macrophage activation)|refseq:NP_599011.2|dip:DIP-61460N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/08	2017/08/10	rogid:TVzltAt+4VNWHR+xzvc8oHRwQ1010090	rogid:V3q4IXpUhw8geyuorfLavOrs2ew10090	rigid:gokoQyU/++FnuRWjWcRW1U4C3fM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)