#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q03135	uniprotkb:O15118	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jelinek et al. (2014)	pubmed:25285302|imex:IM-25661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13641635|imex:IM-25661-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	-	-	-	figure legend:2|antagonist:human LDL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2017/02/02	2017/02/21	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	rigid:m1HRDIuCd5cwuaxL1r8WJH4cEZg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:O15118	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jelinek et al. (2014)	pubmed:25285302|imex:IM-25661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13641640|imex:IM-25661-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	-	-	-	figure legend:2-1|antagonist:human LDL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2017/02/02	2017/02/02	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	rigid:m1HRDIuCd5cwuaxL1r8WJH4cEZg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q03135	uniprotkb:O15118	intact:EBI-603614|ensembl:ENSP00000339191|uniprotkb:Q9UGP1|uniprotkb:Q9UNG1|uniprotkb:Q9UQH6	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:cav1_human(display_long)|uniprotkb:CAV1(gene name)|psi-mi:CAV1(display_short)|uniprotkb:CAV(gene name synonym)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Jelinek et al. (2014)	pubmed:25285302|imex:IM-25661	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13641684|imex:IM-25661-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0052547"(regulation of peptidase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001612(Caveolin)|interpro:IPR015504(Caveolin-1)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|interpro:IPR018361|mint:Q03135|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|reactome:R-HSA-163560|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|reactome:R-HSA-203615|reactome:R-HSA-203641|reactome:R-HSA-210991|reactome:R-HSA-4641262|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|reactome:R-HSA-5218920|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9035034|reactome:R-HSA-9013423|reactome:R-HSA-9617828|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENST00000341049(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|ensembl:ENSG00000105974(gene)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0008104"(protein localization)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030879"(mammary gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0006874"(cellular calcium ion homeostasis)|refseq:NP_001744.2|dip:DIP-5960N	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	-	-	-	figure legend:3|antagonist:human LDL|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-fibroblast)|taxid:9606("Homo sapiens normal diploid fibroblasts (HDF0")	-	2017/02/02	2017/02/02	rogid:+JhGp5YmhT3JLeTgHHBTHu9r34c9606	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	rigid:m1HRDIuCd5cwuaxL1r8WJH4cEZg	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)