#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O15409-1 uniprotkb:Q16650 intact:EBI-16595017|ensembl:ENSP00000265436|ensembl:ENSP00000377132 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-1(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:I(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16595006|imex:IM-26315-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 intact:EBI-16595054(see-also) - - figure legend:6 B/E/F, 7B|comment:Isoform 10+, showed a complete loss of interaction with TBR1.|comment:"Truncated TBR1 proteins with \"de novo\" mutations- A136PfsX80 and S351X, show no binding, as did the R328X mutation."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/16 rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg false renilla luciferase protein tag:n-n mutation disrupting interaction strength:228-228|mutation disrupting interaction strength:374-374|mutation decreasing interaction strength:178-178|mutation decreasing interaction strength:356-356|mutation disrupting interaction strength:418-418|mutation decreasing interaction strength:542-542|sufficient binding region:1-394|yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:O15409-2 uniprotkb:Q16650 intact:EBI-16595037 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-2(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:III(isoform synonym)|uniprotkb:IV(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16595029|imex:IM-26315-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:6B-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/16 rogid:5tgByadk03A90hokSynmkjDPRVs9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FXe7lqjalKuu4Ye7hVDYXsw6Ctc false renilla luciferase protein tag:n-n yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q16650 uniprotkb:Q16650 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16595096|imex:IM-26315-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:5 A/E, Supplementary Fig. 6a/c|comment:"Truncated proteins with \"de novo\" mutations- A136PfsX80 and S351X, show no binding to self or wild type. The synthetic mutation S568X showed homodimerization, but the N394X mutant showed reduced homodimerization."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/16 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FFUT5O3nbJkI+6Y1H6jEBEwXzHg false yellow fluorescent protein tag:n-n renilla luciferase protein tag:n-n|necessary binding region:394-568|mutation decreasing interaction strength:228-228|mutation with no effect:374-374|mutation with no effect:178-178|mutation with no effect:356-356|mutation with no effect:418-418|mutation with no effect:542-542 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:O15409-1 uniprotkb:Q16650 intact:EBI-16595017|ensembl:ENSP00000265436|ensembl:ENSP00000377132 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-1(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:I(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16595178|imex:IM-26315-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:6 D|comment:"All the truncated proteins retained the ability to interact with TBR1 in the BRET assay (Fig. 6d), indicating that the TBR1-binding site lies within the N-terminal 258 residues of FOXP2. The polyglutamine tracts are not required for this interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/16 rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg false renilla luciferase protein tag:n-n|tag:c-c|sufficient binding region:1..1-258..258 yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q16650 uniprotkb:Q16650 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16628261|imex:IM-26315-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:Supplementary Fig. 6a/c|comment:"Truncated proteins with \"de novo\" mutations- A136PfsX80 and S351X, show no binding to self or wild type. The synthetic mutation S568X showed increased homodimerization, but the N394X mutant showed reduced homodimerization."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FFUT5O3nbJkI+6Y1H6jEBEwXzHg false yellow fluorescent protein tag:n-n|necessary binding region:394-568|mutation decreasing interaction strength:228-228|mutation with no effect:374-374|mutation with no effect:178-178|mutation with no effect:356-356|mutation with no effect:418-418|mutation with no effect:542-542 renilla luciferase protein tag:n-n|necessary binding region:394-568|mutation decreasing interaction strength:228-228|mutation with no effect:374-374|mutation with no effect:178-178|mutation with no effect:356-356|mutation with no effect:418-418|mutation with no effect:542-542 - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q9H334 uniprotkb:Q16650 intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16628365|imex:IM-26315-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1 refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:Supplementary figure 8B|comment:Both FOXP1 and FOXP4 were able to interact with TBR1,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:NREo12e1TLPfsul6Ie0l62NqIa89606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:kbWeIeunsj4V3qCQIM323G3D//c false renilla luciferase protein tag:n-n yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:Q8IVH2 uniprotkb:Q16650 intact:EBI-1054619|ensembl:ENSP00000309823|uniprotkb:Q5W098|uniprotkb:Q7Z7F8|uniprotkb:Q8IW55|uniprotkb:Q96E19 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:foxp4_human(display_long)|uniprotkb:FOXP4(gene name)|psi-mi:FOXP4(display_short)|uniprotkb:FKHLA(gene name synonym)|uniprotkb:Fork head-related protein-like A(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16628375|imex:IM-26315-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012426.1|refseq:NP_001012427.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:Q8IVH2|ensembl:ENSG00000137166(gene)|ensembl:ENST00000307972(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|refseq:NP_612466.1|ensembl:ENSP00000362154|ensembl:ENSP00000309823|ensembl:ENST00000373057|ensembl:ENSP00000362148|ensembl:ENST00000373063|dip:DIP-59301N refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 - - - figure legend:Supplementary figure 8B-2|comment:Both FOXP1 and FOXP4 were able to interact with TBR1,|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:8DDWFXo3USEol96m7tKQPHrEc5I9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:q6doZfGoe1nY4R2eSq3Eg7eQE0M false renilla luciferase protein tag:n-n yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:O15409-1 uniprotkb:Q16650 intact:EBI-16595017|ensembl:ENSP00000265436|ensembl:ENSP00000377132 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-1(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:I(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0012"(bioluminescence resonance energy transfer) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-16628385|imex:IM-26315-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0583"(fluorescence donor) psi-mi:"MI:0584"(fluorescence acceptor) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 intact:EBI-16595054(see-also) - - figure legend:Supplementary figure 8E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg false renilla luciferase protein tag:n-n|mutation with no effect:400-400 yellow fluorescent protein tag:n-n - - psi-mi:"MI:0866"(tag visualisation) psi-mi:"MI:0866"(tag visualisation) uniprotkb:O15409-2 uniprotkb:Q16650 intact:EBI-16595037 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-2(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:III(isoform synonym)|uniprotkb:IV(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16595130|imex:IM-26315-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 go:"GO:0005634"(nucleus) - - figure legend:6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/16 rogid:5tgByadk03A90hokSynmkjDPRVs9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FXe7lqjalKuu4Ye7hVDYXsw6Ctc false yellow fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O15409-1 uniprotkb:Q16650 intact:EBI-16595017|ensembl:ENSP00000265436|ensembl:ENSP00000377132 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-1(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:I(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628317|imex:IM-26315-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 intact:EBI-16595150(see-also)|go:"GO:0005634"(nucleus) - - figure legend:6C, 7C, Supplementary figure 8f|comment:Isoform 10+, showed a complete loss of interaction with TBR1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg false yellow fluorescent protein tag:n-n|mutation decreasing interaction strength:553-553|mutation with no effect:400-400 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q8IVH2 uniprotkb:Q16650 intact:EBI-1054619|ensembl:ENSP00000309823|uniprotkb:Q5W098|uniprotkb:Q7Z7F8|uniprotkb:Q8IW55|uniprotkb:Q96E19 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:foxp4_human(display_long)|uniprotkb:FOXP4(gene name)|psi-mi:FOXP4(display_short)|uniprotkb:FKHLA(gene name synonym)|uniprotkb:Fork head-related protein-like A(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628413|imex:IM-26315-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012426.1|refseq:NP_001012427.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|mint:Q8IVH2|ensembl:ENSG00000137166(gene)|ensembl:ENST00000307972(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|refseq:NP_612466.1|ensembl:ENSP00000362154|ensembl:ENSP00000309823|ensembl:ENST00000373057|ensembl:ENSP00000362148|ensembl:ENST00000373063|dip:DIP-59301N refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 go:"GO:0005634"(nucleus) - - figure legend:Supplementary Fig. 8C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:8DDWFXo3USEol96m7tKQPHrEc5I9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:q6doZfGoe1nY4R2eSq3Eg7eQE0M false yellow fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9H334 uniprotkb:Q16650 intact:EBI-983809|uniprotkb:Q9H332|uniprotkb:Q9H333|uniprotkb:Q9P0R1|intact:EBI-28984754|ensembl:ENSP00000318902|ensembl:ENSP00000418102|ensembl:ENSP00000419393|ensembl:ENSP00000496990|ensembl:ENSP00000497344|ensembl:ENSP00000497369|uniprotkb:A3QVP8|uniprotkb:Q9BSG9|uniprotkb:B3KV70|uniprotkb:G5E9V8|uniprotkb:Q8NAN6 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:foxp1_human(display_long)|uniprotkb:FOXP1(gene name)|psi-mi:FOXP1(display_short)|uniprotkb:Mac-1-regulated forkhead(gene name synonym)|uniprotkb:HSPC215(orf name) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628422|imex:IM-26315-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006713165.1|refseq:XP_006713166.1|refseq:XP_006713167.1|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032651"(regulation of interleukin-1 beta production)|go:"GO:0032745"(positive regulation of interleukin-21 production)|go:"GO:0036035"(osteoclast development)|go:"GO:0042116"(macrophage activation)|go:"GO:0042117"(monocyte activation)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045655"(regulation of monocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|ensembl:ENSG00000114861(gene)|ensembl:ENST00000318789(transcript)|ensembl:ENST00000475937(transcript)|ensembl:ENST00000498215(transcript)|ensembl:ENST00000648380(transcript)|ensembl:ENST00000649528(transcript)|ensembl:ENST00000649631(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|rcsb pdb:2KIU|reactome:R-HSA-452723|mint:Q9H334|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061470"(T follicular helper cell differentiation)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1901256"(regulation of macrophage colony-stimulating factor production)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR032354|interpro:IPR036388|interpro:IPR036390|refseq:XP_011531886.1|refseq:XP_011531887.1|refseq:NP_116071.2|refseq:NP_001231743.1|refseq:NP_001231745.1|refseq:NP_001231744.1|refseq:NP_001012523.1|ensembl:ENST00000318779|ensembl:ENSP00000318721|ensembl:ENSP00000318902|ensembl:ENSP00000419393|ensembl:ENST00000484350|ensembl:ENSP00000417857|ensembl:ENST00000493089|ensembl:ENSP00000418524|ensembl:ENSP00000418102|ensembl:ENST00000615603|ensembl:ENSP00000484803|ensembl:ENST00000622151|ensembl:ENSP00000477918|ensembl:ENST00000648107|ensembl:ENSP00000497914|ensembl:ENSP00000497344|ensembl:ENST00000648426|ensembl:ENSP00000498110|ensembl:ENST00000648662|ensembl:ENSP00000496873|ensembl:ENST00000648718|ensembl:ENSP00000496810|ensembl:ENSP00000497369|ensembl:ENSP00000496990|ensembl:ENST00000674446|ensembl:ENSP00000501439|dip:DIP-36585N|refseq:XP_016861654.1|refseq:XP_016861655.1|refseq:XP_016861657.1|refseq:NP_001231741.1|refseq:NP_001231737.1|refseq:NP_001231739.1 refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 go:"GO:0005634"(nucleus) - - figure legend:Supplementary Fig. 8C-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2017/11/17 rogid:NREo12e1TLPfsul6Ie0l62NqIa89606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:kbWeIeunsj4V3qCQIM323G3D//c false yellow fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q16650 uniprotkb:Q16650 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-20584987|imex:IM-26315-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 intact:EBI-16595150(see-also)|go:"GO:0005634"(nucleus) - - figure legend:Supplementary Fig. 6b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/10/16 2018/06/04 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FFUT5O3nbJkI+6Y1H6jEBEwXzHg false yellow fluorescent protein tag:n-n|mutation with no effect:374-374|mutation with no effect:228-228 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O15409-1 uniprotkb:Q16650 intact:EBI-16595017|ensembl:ENSP00000265436|ensembl:ENSP00000377132 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-1(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:I(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16595119|imex:IM-26315-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000128573(gene)|ensembl:ENST00000350908(transcript)|ensembl:ENST00000393494(transcript)|intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 intact:EBI-16628348(see-also)|go:"GO:0005634"(nucleus) - - figure legend:Supplementary Fig. 7|comment:Isoform 10+, showed a complete loss of interaction with TBR1.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2017/10/16 2017/11/16 rogid:XRN9auLs2qtK6W3mjHJHAQPbO9s9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:GKPLo+JA0SpUB7ctOWWE05nT5Vg false yellow fluorescent protein tag:n-n|mutation decreasing interaction strength:553-553 mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:O15409-2 uniprotkb:Q16650 intact:EBI-16595037 intact:EBI-1047158|ensembl:ENSP00000374205|uniprotkb:Q14DC5|uniprotkb:Q53TH0|uniprotkb:B2R6G5|uniprotkb:Q56A81|uniprotkb:B0AZS4 psi-mi:o15409-2(display_long)|uniprotkb:CAG repeat protein 44(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 10 protein(gene name synonym)|uniprotkb:III(isoform synonym)|uniprotkb:IV(isoform synonym)|uniprotkb:FOXP2(gene name)|psi-mi:FOXP2(display_short)|uniprotkb:CAGH44(gene name synonym)|uniprotkb:TNRC10(gene name synonym) psi-mi:tbr1_human(display_long)|uniprotkb:TES-56(gene name synonym)|uniprotkb:TBR1(gene name)|psi-mi:TBR1(display_short) psi-mi:"MI:0663"(confocal microscopy) Deriziotis et al. (2014) imex:IM-26315|pubmed:25232744 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-16628308|imex:IM-26315-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-983612(isoform-parent) refseq:NP_006584.1|ensembl:ENSG00000136535(gene)|ensembl:ENST00000389554(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0010092"(specification of animal organ identity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030902"(hindbrain development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR032385|interpro:IPR036960|mint:Q16650 go:"GO:0005634"(nucleus) - - figure legend:Supplementary Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-sh_sy5y)|taxid:9606(Homo sapiens SH-SY5Y cell line) - 2017/10/16 2017/11/17 rogid:5tgByadk03A90hokSynmkjDPRVs9606 rogid:qD1euHkX/welvC2klFM95IiAiWE9606 rigid:FXe7lqjalKuu4Ye7hVDYXsw6Ctc false yellow fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)