#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P20967 uniprotkb:P19955 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416359|imex:IM-26148-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F - figure legend:Fig.1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P20967 uniprotkb:P19262 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416359|imex:IM-26148-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:C06FEB1DE385AE19 figure legend:Fig.1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P20967 uniprotkb:P09624 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416359|imex:IM-26148-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:986A370F2E079DBC figure legend:Fig.1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P19955 uniprotkb:P20967 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416388|imex:IM-26148-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N go:"GO:0005739"(mitochondrion) - crc64:EF987C4DECE3F09F figure legend:Fig.1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P19262 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416388|imex:IM-26148-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) - crc64:C06FEB1DE385AE19 figure legend:Fig.1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P09624 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416388|imex:IM-26148-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005739"(mitochondrion) - crc64:986A370F2E079DBC figure legend:Fig.1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09624 uniprotkb:P19955 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416401|imex:IM-26148-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 go:"GO:0005739"(mitochondrion) crc64:986A370F2E079DBC - figure legend:Fig.3C|comment:Interaction not observed in YMR31-/- cells although the interaction with Lpd1 still occurs.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09624 uniprotkb:P20967 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416401|imex:IM-26148-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N go:"GO:0005739"(mitochondrion) crc64:986A370F2E079DBC crc64:EF987C4DECE3F09F figure legend:Fig.3C|comment:Interaction not observed in YMR31-/- cells although the interaction with Lpd1 still occurs.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P09624 uniprotkb:P19262 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416401|imex:IM-26148-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) crc64:986A370F2E079DBC crc64:C06FEB1DE385AE19 figure legend:Fig.3C|comment:Interaction not observed in YMR31-/- cells although the interaction with Lpd1 still occurs.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20967 uniprotkb:P19955 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416419|imex:IM-26148-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F - figure legend:Fig.3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20967 uniprotkb:P19262 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416419|imex:IM-26148-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:C06FEB1DE385AE19 figure legend:Fig.3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20967 uniprotkb:P09624 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416419|imex:IM-26148-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:986A370F2E079DBC figure legend:Fig.3D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:FsAEncLeQMvVX4NB7Uy3eQZzDOw false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20967 uniprotkb:P19262 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416429|imex:IM-26148-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:C06FEB1DE385AE19 figure legend:Fig.3D|comment:Interaction observed in YMR31-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/10/27 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:ttq5XrmTYaSI+pKcvUnMmZ1w3wM false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P09624 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416439|imex:IM-26148-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005739"(mitochondrion) - crc64:986A370F2E079DBC figure legend:Fig.3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:7D7LEZeFgGrfxIaVkt+l3odDew8 false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P09624 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416475|imex:IM-26148-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005739"(mitochondrion) - crc64:986A370F2E079DBC figure legend:Fig.7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/11/06 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:hsIeBrqNlt0Do2gJ7UjaUlrFD8s false his tag:c-c|sufficient binding region:1-68|protein a tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P19262 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416475|imex:IM-26148-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) - crc64:C06FEB1DE385AE19 figure legend:Fig.7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/11/06 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:hsIeBrqNlt0Do2gJ7UjaUlrFD8s false his tag:c-c|sufficient binding region:1-68|protein a tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P20967 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416550|imex:IM-26148-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N go:"GO:0005739"(mitochondrion) - crc64:EF987C4DECE3F09F figure legend:Fig.7C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/11/06 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rigid:NX/6eIP+h1J/u7rYYQ6czviopTY false his tag:c-c|sufficient binding region:69-123|protein a tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19955 uniprotkb:P19262 intact:EBI-16295|ensemblfungi:YFR049W|uniprotkb:D6VTT2 intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:rt31_yeast(display_long)|uniprotkb:YFR049W(locus name)|uniprotkb:YMR31(gene name)|psi-mi:YMR31(display_short) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0096"(pull down) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416550|imex:IM-26148-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000001945|ensemblfungi:YFR049W(gene)|ensemblfungi:YFR049W_mRNA(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|interpro:IPR020373|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|refseq:NP_116707.3|dip:DIP-5447N|mint:P19955 ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) - crc64:C06FEB1DE385AE19 figure legend:Fig.7C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/11/06 rogid:6QZyCc2+sOr3rdTswAxjMopU9/A559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:NX/6eIP+h1J/u7rYYQ6czviopTY false his tag:c-c|sufficient binding region:69-123|protein a tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19262 uniprotkb:P09624 intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 intact:EBI-5940|uniprotkb:D6VTL1|ensemblfungi:YFL018C psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:dldh_yeast(display_long)|uniprotkb:YFL018C(locus name)|uniprotkb:LPD1(gene name)|psi-mi:LPD1(display_short)|uniprotkb:DHLP1(gene name synonym)|uniprotkb:Dihydrolipoamide dehydrogenase(gene name synonym)|uniprotkb:Lipoamide dehydrogenase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex E3 component(gene name synonym)|uniprotkb:Glycine decarboxylase complex subunit L(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416452|imex:IM-26148-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N refseq:NP_116635.1|sgd:S000001876|dip:DIP-41N|mint:P09624|ensemblfungi:YFL018C(gene)|ensemblfungi:YFL018C_mRNA(transcript)|go:"GO:0004148"(dihydrolipoyl dehydrogenase activity)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0004738"(pyruvate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006552"(leucine catabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006574"(valine catabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001100(Pyridine nucleotide-disulphide oxidoreductase, class I)|interpro:IPR004099(Pyridine nucleotide-disulphide oxidoreductase, dimerisation)|interpro:IPR006258(Dihydrolipoamide dehydrogenase)|interpro:IPR012999(Pyridine nucleotide-disulphide oxidoreductase, class I, active site)|interpro:IPR016156(FAD/NAD-linked reductase, dimerisation)|interpro:IPR023753|interpro:IPR036188|rcsb pdb:1JEH|rcsb pdb:1V59|reactome:R-SCE-389661|reactome:R-SCE-6783984|reactome:R-SCE-70268|reactome:R-SCE-71064|reactome:R-SCE-71403 go:"GO:0005634"(nucleus) crc64:C06FEB1DE385AE19 crc64:986A370F2E079DBC figure legend:Fig.4B|comment:Interaction decreased in YMR31-/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/09/14 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rogid:R6s8DY/LUg5Bolkdq1Ia1UHUxV4559292 rigid:kY65BLH+P3PZTD1vRpoVqWkXJsk false - his tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20967 uniprotkb:P19262 intact:EBI-12459|uniprotkb:D6VVG2|ensemblfungi:YIL125W intact:EBI-12464|ensemblfungi:YDR148C|uniprotkb:D6VSD1 psi-mi:odo1_yeast(display_long)|uniprotkb:YIL125W(locus name)|uniprotkb:KGD1(gene name)|psi-mi:KGD1(display_short)|uniprotkb:OGD1(gene name synonym)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:odo2_yeast(display_long)|uniprotkb:KGD2(gene name)|psi-mi:KGD2(display_short)|uniprotkb:YDR148C(locus name)|uniprotkb:YD8358.05C(orf name)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Heublein et al. (2014) imex:IM-26148|pubmed:25165143 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-16416465|imex:IM-26148-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YIL125W(gene)|ensemblfungi:YIL125W_mRNA(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|refseq:NP_012141.1|sgd:S000001387|mint:P20967|dip:DIP-365N ensemblfungi:YDR148C(gene)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009353"(mitochondrial oxoglutarate dehydrogenase complex)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|reactome:R-SCE-389661|reactome:R-SCE-71064|reactome:R-SCE-71403|ensemblfungi:YDR148C_mRNA(transcript)|refseq:NP_010432.3|sgd:S000002555|mint:P19262|dip:DIP-1102N go:"GO:0005739"(mitochondrion) crc64:EF987C4DECE3F09F crc64:C06FEB1DE385AE19 figure legend:Fig.4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2017/09/14 2017/10/18 rogid:nV2jgtkIIae4kSwMo4ekDWxVG3s559292 rogid:VvkX3OlSTvsDm/t52o6/bdq807E559292 rigid:ttq5XrmTYaSI+pKcvUnMmZ1w3wM false his tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)