#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Itou et al. (2014)	pubmed:25126958|doi:10.1016/j.str.2014.07.001|imex:IM-23122	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16117659|imex:IM-23122-1|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	-	sufficient binding region:148-430|necessary binding region:301-330|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0071"(molecular sieving)	Itou et al. (2014)	pubmed:25126958|doi:10.1016/j.str.2014.07.001|imex:IM-23122	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16117708|imex:IM-23122-3|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	-	sufficient binding region:148-430	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Itou et al. (2014)	pubmed:25126958|doi:10.1016/j.str.2014.07.001|imex:IM-23122	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16117727|imex:IM-23122-4|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	mutation disrupting interaction strength:91-91,124-124,149-150	sufficient binding region:148-430|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Itou et al. (2014)	pubmed:25126958|doi:10.1016/j.str.2014.07.001|imex:IM-23122	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16117682|imex:IM-23122-2|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	mutation disrupting interaction strength:91-91,124-124,149-150	his tag:c-c|sufficient binding region:296-332	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q08032	uniprotkb:P53135	intact:EBI-4292|uniprotkb:Q05908|uniprotkb:D6VYA3|ensemblfungi:YLR103C	intact:EBI-23925|uniprotkb:D6VU34|ensemblfungi:YGL113W	psi-mi:cdc45_yeast(display_long)|uniprotkb:CDC45(gene name)|psi-mi:CDC45(display_short)|uniprotkb:YLR103C(locus name)|uniprotkb:L8004.11(orf name)|uniprotkb:SLD4(gene name synonym)	psi-mi:sld3_yeast(display_long)|uniprotkb:SLD3(gene name)|psi-mi:SLD3(display_short)|uniprotkb:G2980(orf name)|uniprotkb:YGL113W(locus name)	psi-mi:"MI:0096"(pull down)	Itou et al. (2014)	pubmed:25126958|doi:10.1016/j.str.2014.07.001|imex:IM-23122	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16117753|imex:IM-23122-5|dip:DIP-187424E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013204.1|sgd:S000004093|dip:DIP-2405N|mint:Q08032|ensemblfungi:YLR103C(gene)|ensemblfungi:YLR103C_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031938"(obsolete regulation of chromatin silencing at telomere)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0071162"(CMG complex)|go:"GO:1902977"(mitotic DNA replication preinitiation complex assembly)|interpro:IPR003874(CDC45-like protein)|rcsb pdb:3JC5|rcsb pdb:3JC6|rcsb pdb:3JC7|rcsb pdb:5U8S|rcsb pdb:5U8T|rcsb pdb:6HV9|rcsb pdb:6PTJ|rcsb pdb:6PTN|rcsb pdb:6PTO|rcsb pdb:6SKL|rcsb pdb:6U0M|reactome:R-SCE-68962	sgd:S000003081|refseq:NP_011402.3|dip:DIP-5481N|mint:P53135|ensemblfungi:YGL113W(gene)|ensemblfungi:YGL113W_mRNA(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0031261"(DNA replication preinitiation complex)|interpro:IPR013948(DNA replication regulator Sld3)|interpro:IPR041393|interpro:IPR042511|rcsb pdb:3WI3	psi-mi:"MI:0465"(dip)	crc64:6500DDD62EC4E8EE	crc64:6E59D0DB3C082C28	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:ErMEWxRKsJsPBDo5EfTfBL57hAY559292	rogid:1uxenWX3lYYMDUWr0mAE207XsHI559292	rigid:uw4fgpDwG3RC5ozWdAdZjE0hM8g	false	-	sufficient binding region:296-332|necessary binding region:301-330|his tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)