#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9VCY3 uniprotkb:Q9XZ58 intact:EBI-183494|ensemblmetazoa:FBpp0083658 intact:EBI-97187|uniprotkb:Q7KN57|uniprotkb:Q9UB04|ensemblmetazoa:FBpp0082743 psi-mi:csn6_drome(display_long)|uniprotkb:CSN6(gene name)|psi-mi:CSN6(display_short)|uniprotkb:CG6932(orf name) psi-mi:csn5_drome(display_long)|uniprotkb:CSN5(gene name)|psi-mi:CSN5(display_short)|uniprotkb:CG14884(orf name)|uniprotkb:quo(gene name synonym)|uniprotkb:JAB1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117193|imex:IM-23364-1|dip:DIP-28981E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524451.1|flybase:FBgn0028837|ensemblmetazoa:FBgn0028837(gene)|ensemblmetazoa:FBtr0084265(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033859|interpro:IPR037518|rcsb pdb:4E0Q|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664 refseq:NP_477442.1|flybase:FBgn0027053|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-6781823|ensemblmetazoa:FBgn0027053(gene)|ensemblmetazoa:FBtr0083292(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007281"(germ cell development)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0035207"(negative regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|reactome:R-DME-5696394|dip:DIP-22022N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:l+cqdzhih02kxZCFNNMTsGlb3DQ7227 rogid:bvwuY3mncpz5R3dfJ+O9jMp9PhQ7227 rigid:76M5fFmk0QX7hLAl4LUqdiRtNqc false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9W1I2 uniprotkb:P22745 intact:EBI-142483|uniprotkb:Q9W1I3|ensemblmetazoa:FBpp0072141 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:bgcn_drome(display_long)|uniprotkb:bgcn(gene name)|psi-mi:bgcn(display_short)|uniprotkb:"b(2)gcn"(gene name synonym)|uniprotkb:CG30170(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0018"(two hybrid) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117280|imex:IM-23364-5|dip:DIP-103854E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_523832.2|flybase:FBgn0004581|dip:DIP-48890N|ensemblmetazoa:FBgn0004581(gene)|ensemblmetazoa:FBtr0072232(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0048477"(oogenesis)|go:"GO:0098730"(male germline stem cell symmetric division)|interpro:IPR002110(Ankyrin)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|interpro:IPR036770 ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:9FSjffCDwFNl3/5tWrHGdqohIr07227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:ZpZs0Od4hSbPe6jo+S1HtvcHM3c false - sufficient binding region:101-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9VCY3 uniprotkb:Q9V345 intact:EBI-183494|ensemblmetazoa:FBpp0083658 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:csn6_drome(display_long)|uniprotkb:CSN6(gene name)|psi-mi:CSN6(display_short)|uniprotkb:CG6932(orf name) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117259|imex:IM-23364-4|dip:DIP-197353E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_524451.1|flybase:FBgn0028837|ensemblmetazoa:FBgn0028837(gene)|ensemblmetazoa:FBtr0084265(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033859|interpro:IPR037518|rcsb pdb:4E0Q|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664 ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:l+cqdzhih02kxZCFNNMTsGlb3DQ7227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rigid:5ytBNaPICkGHkRaz/ODSzCxUxiE false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P22745 uniprotkb:Q9W1I2 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 intact:EBI-142483|uniprotkb:Q9W1I3|ensemblmetazoa:FBpp0072141 psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:bgcn_drome(display_long)|uniprotkb:bgcn(gene name)|psi-mi:bgcn(display_short)|uniprotkb:"b(2)gcn"(gene name synonym)|uniprotkb:CG30170(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16117235|imex:IM-23364-3|dip:DIP-197351E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N refseq:NP_523832.2|flybase:FBgn0004581|dip:DIP-48890N|ensemblmetazoa:FBgn0004581(gene)|ensemblmetazoa:FBtr0072232(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0048477"(oogenesis)|go:"GO:0098730"(male germline stem cell symmetric division)|interpro:IPR002110(Ankyrin)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|interpro:IPR036770 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rogid:9FSjffCDwFNl3/5tWrHGdqohIr07227 rigid:SRfH5qsYGULH249a8LR0JS5cH+M false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P22745 uniprotkb:Q9V345 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16117235|imex:IM-23364-3|dip:DIP-197351E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rigid:SRfH5qsYGULH249a8LR0JS5cH+M false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V345 uniprotkb:P22745 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0018"(two hybrid) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117214|imex:IM-23364-2|dip:DIP-197350E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/08 2017/08/10 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:JddrH+oMcDSgD3tA4uYRg5nMg+c false - sufficient binding region:151-300|sufficient binding region:201-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9XZ58 uniprotkb:Q9V345 intact:EBI-97187|uniprotkb:Q7KN57|uniprotkb:Q9UB04|ensemblmetazoa:FBpp0082743 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:csn5_drome(display_long)|uniprotkb:CSN5(gene name)|psi-mi:CSN5(display_short)|uniprotkb:CG14884(orf name)|uniprotkb:quo(gene name synonym)|uniprotkb:JAB1 homolog(gene name synonym) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117406|imex:IM-23364-11|dip:DIP-197352E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_477442.1|flybase:FBgn0027053|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-6781823|ensemblmetazoa:FBgn0027053(gene)|ensemblmetazoa:FBtr0083292(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007281"(germ cell development)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007314"(oocyte anterior/posterior axis specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008347"(glial cell migration)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035204"(negative regulation of lamellocyte differentiation)|go:"GO:0035207"(negative regulation of hemocyte proliferation)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|reactome:R-DME-5696394|dip:DIP-22022N ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:bvwuY3mncpz5R3dfJ+O9jMp9PhQ7227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rigid:qn7yU0FHvlJbcLRbjDN8sP8mZSc false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9W1I2 uniprotkb:P22745 intact:EBI-142483|uniprotkb:Q9W1I3|ensemblmetazoa:FBpp0072141 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:bgcn_drome(display_long)|uniprotkb:bgcn(gene name)|psi-mi:bgcn(display_short)|uniprotkb:"b(2)gcn"(gene name synonym)|uniprotkb:CG30170(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117383|imex:IM-23364-10|dip:DIP-103854E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_523832.2|flybase:FBgn0004581|dip:DIP-48890N|ensemblmetazoa:FBgn0004581(gene)|ensemblmetazoa:FBtr0072232(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007281"(germ cell development)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0048477"(oogenesis)|go:"GO:0098730"(male germline stem cell symmetric division)|interpro:IPR002110(Ankyrin)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|interpro:IPR036770 ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:9FSjffCDwFNl3/5tWrHGdqohIr07227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:ZpZs0Od4hSbPe6jo+S1HtvcHM3c false myc tag:n-n flag tag:n-n|sufficient binding region:101-400 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V4S8 uniprotkb:Q9V345 intact:EBI-155199|uniprotkb:Q6NLA1|ensemblmetazoa:FBpp0087821 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 psi-mi:csn7_drome(display_long)|uniprotkb:CSN7(gene name)|psi-mi:CSN7(display_short)|uniprotkb:CG2038(orf name) psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117362|imex:IM-23364-9|dip:DIP-197354E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610379.2|flybase:FBgn0028836|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027530|interpro:IPR041481|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|ensemblmetazoa:FBgn0028836(gene)|ensemblmetazoa:FBtr0088742(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0034399"(nuclear periphery)|go:"GO:0036099"(female germ-line stem cell population maintenance)|dip:DIP-22982N ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:4DB2dArl0aEGtX7tjPBMyESATF07227 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rigid:a1i1VCMTNKovTRmc3rc5Orf9a/8 false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V345 uniprotkb:P22745 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117343|imex:IM-23364-8|dip:DIP-197350E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:JddrH+oMcDSgD3tA4uYRg5nMg+c false ha tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V4S8 uniprotkb:Q9VCY3 intact:EBI-155199|uniprotkb:Q6NLA1|ensemblmetazoa:FBpp0087821 intact:EBI-183494|ensemblmetazoa:FBpp0083658 psi-mi:csn7_drome(display_long)|uniprotkb:CSN7(gene name)|psi-mi:CSN7(display_short)|uniprotkb:CG2038(orf name) psi-mi:csn6_drome(display_long)|uniprotkb:CSN6(gene name)|psi-mi:CSN6(display_short)|uniprotkb:CG6932(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117322|imex:IM-23364-7|dip:DIP-197355E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_610379.2|flybase:FBgn0028836|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048142"(germarium-derived cystoblast division)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027530|interpro:IPR041481|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|ensemblmetazoa:FBgn0028836(gene)|ensemblmetazoa:FBtr0088742(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0034399"(nuclear periphery)|go:"GO:0036099"(female germ-line stem cell population maintenance)|dip:DIP-22982N refseq:NP_524451.1|flybase:FBgn0028837|ensemblmetazoa:FBgn0028837(gene)|ensemblmetazoa:FBtr0084265(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033859|interpro:IPR037518|rcsb pdb:4E0Q|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:4DB2dArl0aEGtX7tjPBMyESATF07227 rogid:l+cqdzhih02kxZCFNNMTsGlb3DQ7227 rigid:amiyesJ1wnqEhlDTlW9TJtIXfhw false myc tag:n-n flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V345 uniprotkb:P22745 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117299|imex:IM-23364-6|dip:DIP-197350E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:JddrH+oMcDSgD3tA4uYRg5nMg+c false myc tag:n-n flag tag:n-n|sufficient binding region:101-300 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9V345 uniprotkb:P22745 intact:EBI-141466|ensemblmetazoa:FBpp0087935|ensemblmetazoa:FBpp0290448|uniprotkb:Q9XYW5 intact:EBI-88504|uniprotkb:Q2PNQ8|uniprotkb:Q2PNQ9|uniprotkb:Q2PNR5|uniprotkb:Q2PNR8|uniprotkb:Q2PNR9|uniprotkb:Q2PNS3|uniprotkb:Q2PNS6|uniprotkb:Q2PNS8|uniprotkb:Q2PNT1|uniprotkb:Q8MRX8|uniprotkb:Q9VBV0|ensemblmetazoa:FBpp0084243 psi-mi:csn4_drome(display_long)|uniprotkb:CSN4(gene name)|psi-mi:CSN4(display_short)|uniprotkb:CG8725(orf name) psi-mi:bam_drome(display_long)|uniprotkb:bam(gene name)|psi-mi:bam(display_short)|uniprotkb:CG10422(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pan et al. (2014) pubmed:25119050|doi:10.1038/nature13562|imex:IM-23364 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16117427|imex:IM-23364-12|dip:DIP-197350E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBtr0088859(transcript)|ensemblmetazoa:FBtr0301230(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005829"(cytosol)|ensemblmetazoa:FBgn0027054(gene)|go:"GO:0007281"(germ cell development)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0048140"(male germ-line cyst encapsulation)|go:"GO:0048477"(oogenesis)|go:"GO:0050821"(protein stabilization)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|reactome:R-DME-5696394|reactome:R-DME-6781823|reactome:R-DME-8856825|reactome:R-DME-8951664|reactome:R-DME-9013422|refseq:NP_001163080.1|refseq:NP_477444.1|flybase:FBgn0027054|dip:DIP-52178N ensemblmetazoa:FBgn0000158(gene)|ensemblmetazoa:FBtr0084869(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007276"(gamete generation)|go:"GO:0007282"(cystoblast division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045169"(fusome)|go:"GO:0045170"(spectrosome)|go:"GO:0045478"(fusome organization)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048132"(female germ-line stem cell asymmetric division)|go:"GO:0048477"(oogenesis)|go:"GO:0061060"(negative regulation of peptidoglycan recognition protein signaling pathway)|go:"GO:0098730"(male germline stem cell symmetric division)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:2000738"(positive regulation of stem cell differentiation)|rcsb pdb:5ONA|rcsb pdb:5ONB|go:"GO:0042078"(germ-line stem cell division)|refseq:NP_476800.1|flybase:FBgn0000158|dip:DIP-48889N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/08 2017/08/10 rogid:Q2daroWgqO7i1NRPR9REIsEOtvo7227 rogid:+yKbVZi2wU21FCl18d28yxs8xsQ7227 rigid:JddrH+oMcDSgD3tA4uYRg5nMg+c false myc tag:n-n|necessary binding region:287-407 flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)