#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9D8B7	uniprotkb:P25774-1	intact:EBI-7580787|uniprotkb:Q8BT59|uniprotkb:Q9EPK4|intact:MINT-1344650|uniprotkb:Q9D1M9|ensembl:ENSMUSP00000034472	intact:EBI-16115607|ensembl:ENSP00000357981|ensembl:ENSP00000475176|ensembl:ENSP00000475557|ensembl:ENSP00000505359	psi-mi:jam3_mouse(display_long)|uniprotkb:Jam3(gene name)|psi-mi:Jam3(display_short)|uniprotkb:Junctional adhesion molecule 3(gene name synonym)|uniprotkb:JAM-2(gene name synonym)	psi-mi:p25774-1(display_long)|uniprotkb:CTSS(gene name)|psi-mi:CTSS(display_short)	psi-mi:"MI:0435"(protease assay)	Sevenich et al. (2014)	pubmed:25086747|doi:10.1038/ncb3011|imex:IM-23369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16115612|imex:IM-23369-1|dip:DIP-197370E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075766.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045176"(apical protein localization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070160"(tight junction)|go:"GO:0042552"(myelination)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:0090138"(regulation of actin cytoskeleton organization by cell-cell adhesion)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905710"(positive regulation of membrane permeability)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042974|rcsb pdb:5GMI|reactome:R-MMU-202733|reactome:R-MMU-216083|ensembl:ENSMUSG00000031990(gene)|ensembl:ENSMUST00000034472(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030057"(desmosome)|go:"GO:0031103"(axon regeneration)|go:"GO:0031941"(filamentous actin)|go:"GO:0033010"(paranodal junction)|go:"GO:0033624"(negative regulation of integrin activation)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|dip:DIP-42154N	intact:EBI-2808345(isoform-parent)|ensembl:ENSG00000163131(gene)|ensembl:ENST00000368985(transcript)|ensembl:ENST00000472977(transcript)|ensembl:ENST00000607427(transcript)|ensembl:ENST00000681444(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|function:May participate in cell-cell adhesion distinct from tight junctions	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:XjbMt5h9YKD4s1831+RNP9cAwjo10090	rogid:/47OYPCznvm6Z1si/zQXey+Nk0U9606	rigid:A69FBgZyM2M0ctg2M2H9o5E+h2M	false	sufficient binding region:32-241	sufficient binding region:109-331	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88792	uniprotkb:P25774-1	intact:EBI-7580837|intact:MINT-247376|uniprotkb:Q8VC39|intact:MINT-4119377|ensembl:ENSMUSP00000041907	intact:EBI-16115607|ensembl:ENSP00000357981|ensembl:ENSP00000475176|ensembl:ENSP00000475557|ensembl:ENSP00000505359	psi-mi:jam1_mouse(display_long)|uniprotkb:F11r(gene name)|psi-mi:F11r(display_short)|uniprotkb:Jam1(gene name synonym)|uniprotkb:Jcam(gene name synonym)|uniprotkb:Jcam1(gene name synonym)|uniprotkb:Junctional adhesion molecule 1(gene name synonym)	psi-mi:p25774-1(display_long)|uniprotkb:CTSS(gene name)|psi-mi:CTSS(display_short)	psi-mi:"MI:0435"(protease assay)	Sevenich et al. (2014)	pubmed:25086747|doi:10.1038/ncb3011|imex:IM-23369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16115633|imex:IM-23369-2|dip:DIP-197368E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766235.1|ensembl:ENSMUSG00000038235(gene)|ensembl:ENSMUST00000043839(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050892"(intestinal absorption)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:1901731"(positive regulation of platelet aggregation)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042456|mint:O88792|rcsb pdb:1F97|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-2173791|reactome:R-MMU-420029|go:"GO:0098609"(cell-cell adhesion)|dip:DIP-41166N	intact:EBI-2808345(isoform-parent)|ensembl:ENSG00000163131(gene)|ensembl:ENST00000368985(transcript)|ensembl:ENST00000472977(transcript)|ensembl:ENST00000607427(transcript)|ensembl:ENST00000681444(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|function:Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:eM6EU7qHKBw4lJ4jpg5388hIza010090	rogid:/47OYPCznvm6Z1si/zQXey+Nk0U9606	rigid:gsOep5OZiCshPqqeyOCY/gIvuic	false	sufficient binding region:27-242	sufficient binding region:109-331	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15551	uniprotkb:P25774-1	intact:EBI-4290490|ensembl:ENSP00000378577	intact:EBI-16115607|ensembl:ENSP00000357981|ensembl:ENSP00000475176|ensembl:ENSP00000475557|ensembl:ENSP00000505359	psi-mi:cld3_human(display_long)|uniprotkb:CLDN3(gene name)|psi-mi:CLDN3(display_short)|uniprotkb:C7orf1(gene name synonym)|uniprotkb:CPETR2(gene name synonym)|uniprotkb:Clostridium perfringens enterotoxin receptor 2(gene name synonym)|uniprotkb:Rat ventral prostate.1 protein homolog(gene name synonym)	psi-mi:p25774-1(display_long)|uniprotkb:CTSS(gene name)|psi-mi:CTSS(display_short)	psi-mi:"MI:0435"(protease assay)	Sevenich et al. (2014)	pubmed:25086747|doi:10.1038/ncb3011|imex:IM-23369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16115654|imex:IM-23369-3|dip:DIP-197372E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-420029|interpro:IPR006187(Claudin)|interpro:IPR017974|ensembl:ENSG00000165215(gene)|ensembl:ENST00000395145(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014045"(establishment of endothelial blood-brain barrier)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034331"(cell junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045471"(response to ethanol)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903348"(positive regulation of bicellular tight junction assembly)|go:"GO:1905050"(positive regulation of metallopeptidase activity)|interpro:IPR003549(Claudin-3)|go:"GO:0030336"(negative regulation of cell migration)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|refseq:NP_001297.1|dip:DIP-61079N	intact:EBI-2808345(isoform-parent)|ensembl:ENSG00000163131(gene)|ensembl:ENST00000368985(transcript)|ensembl:ENST00000472977(transcript)|ensembl:ENST00000607427(transcript)|ensembl:ENST00000681444(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:bbVfW5VlbBiaQCIDRszD40tzFqo9606	rogid:/47OYPCznvm6Z1si/zQXey+Nk0U9606	rigid:KHnBJ9ABEUc0iG7yPJbHwEqjR3k	false	-	sufficient binding region:109-331	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16625-1	uniprotkb:P25774-1	intact:EBI-16115673|ensembl:ENSP00000347379|ensembl:ENSP00000379719|ensembl:ENSP00000505426|ensembl:ENSP00000505541|ensembl:ENSP00000506162	intact:EBI-16115607|ensembl:ENSP00000357981|ensembl:ENSP00000475176|ensembl:ENSP00000475557|ensembl:ENSP00000505359	psi-mi:q16625-1(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short)|uniprotkb:WT-OCLN(isoform synonym)|uniprotkb:"TM4(+)"(isoform synonym)	psi-mi:p25774-1(display_long)|uniprotkb:CTSS(gene name)|psi-mi:CTSS(display_short)	psi-mi:"MI:0435"(protease assay)	Sevenich et al. (2014)	pubmed:25086747|doi:10.1038/ncb3011|imex:IM-23369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16115681|imex:IM-23369-4|dip:DIP-197371E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197822(gene)|ensembl:ENST00000355237(transcript)|ensembl:ENST00000396442(transcript)|ensembl:ENST00000680027(transcript)|ensembl:ENST00000681041(transcript)|ensembl:ENST00000681586(transcript)|intact:EBI-2903088(isoform-parent)	intact:EBI-2808345(isoform-parent)|ensembl:ENSG00000163131(gene)|ensembl:ENST00000368985(transcript)|ensembl:ENST00000472977(transcript)|ensembl:ENST00000607427(transcript)|ensembl:ENST00000681444(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:RyZ9uIVH0TdDwlIFaGJJYbuHvmY9606	rogid:/47OYPCznvm6Z1si/zQXey+Nk0U9606	rigid:nEEHBDXhPZ2g4vXjfB+MKvyFIiQ	false	-	sufficient binding region:109-331	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JI59	uniprotkb:P25774-1	intact:EBI-16115700|ensembl:ENSMUSP00000109833|uniprotkb:A6X955|uniprotkb:Q8C5K9|uniprotkb:Q8CE95	intact:EBI-16115607|ensembl:ENSP00000357981|ensembl:ENSP00000475176|ensembl:ENSP00000475557|ensembl:ENSP00000505359	psi-mi:jam2_mouse(display_long)|uniprotkb:Jam2(gene name)|psi-mi:Jam2(display_short)|uniprotkb:Vejam(gene name synonym)|uniprotkb:Junctional adhesion molecule 2(gene name synonym)|uniprotkb:Vascular endothelial junction-associated molecule(gene name synonym)	psi-mi:p25774-1(display_long)|uniprotkb:CTSS(gene name)|psi-mi:CTSS(display_short)	psi-mi:"MI:0435"(protease assay)	Sevenich et al. (2014)	pubmed:25086747|doi:10.1038/ncb3011|imex:IM-23369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16115728|imex:IM-23369-5|dip:DIP-197369E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000053062(gene)|ensembl:ENSMUST00000114195(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045123"(cellular extravasation)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070160"(tight junction)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:2000403"(positive regulation of lymphocyte migration)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042625|rcsb pdb:5GMJ|reactome:R-MMU-202733|reactome:R-MMU-216083|refseq:NP_076333.3|dip:DIP-61078N	intact:EBI-2808345(isoform-parent)|ensembl:ENSG00000163131(gene)|ensembl:ENST00000368985(transcript)|ensembl:ENST00000472977(transcript)|ensembl:ENST00000607427(transcript)|ensembl:ENST00000681444(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:nWaF7c90ac3ro0jaPbJujd54B9U10090	rogid:/47OYPCznvm6Z1si/zQXey+Nk0U9606	rigid:dDcoPKE3SIcENj6mcvm8PQNIphM	false	sufficient binding region:26-236	sufficient binding region:109-331	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)