#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9GT24	uniprotkb:Q9GT24	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110861|imex:IM-23115-2|dip:DIP-197146E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:7a/qN2tgp6RDCawIDAj+XmGAPBc	false	sufficient binding region:338-564	sufficient binding region:338-564	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VNE4	uniprotkb:O97143	intact:EBI-108604|uniprotkb:Q7YTY4|ensemblmetazoa:FBpp0078392	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:q9vne4_drome(display_long)|uniprotkb:DmAsl(gene name synonym)|uniprotkb:asl(gene name)|psi-mi:asl(display_short)|uniprotkb:CG2919(orf name)|uniprotkb:ASL(gene name synonym)|uniprotkb:Asl(gene name synonym)|uniprotkb:Dmel\CG2919(gene name synonym)|uniprotkb:mecD(gene name synonym)|uniprotkb:sdu(gene name synonym)|uniprotkb:Dmel_CG2919(orf name)|uniprotkb:Cep152(gene name synonym)|uniprotkb:MecD(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110840|imex:IM-23115-1|dip:DIP-188230E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649557.2|flybase:FBgn0261004|dip:DIP-59503N|ensemblmetazoa:FBgn0261004(gene)|ensemblmetazoa:FBtr0078743(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007338"(single fertilization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0036064"(ciliary basal body)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1905515"(non-motile cilium assembly)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6PZMMJBBhXtp8MaXHx9klNTsnig7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:5dVig8qkRcvsqdw4fxmsKsiWovA	false	sufficient binding region:21-60	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GT24	uniprotkb:Q9GT24	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110879|imex:IM-23115-3|dip:DIP-197146E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:7a/qN2tgp6RDCawIDAj+XmGAPBc	false	sufficient binding region:338-564	sufficient binding region:338-564	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110897|imex:IM-23115-4|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	sufficient binding region:1-147	sufficient binding region:338-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:E9Q4Y4	uniprotkb:Q9GT24	intact:EBI-16110918|ensembl:ENSMUSP00000025425	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:e9q4y4_mouse(display_long)|uniprotkb:Cep192(gene name)|psi-mi:Cep192(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110950|imex:IM-23115-5|dip:DIP-197149E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000024542(gene)|ensembl:ENSMUST00000025425(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_081832.1|dip:DIP-61008N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:xunbTiymnpjmUcri1DATiSH61XY10090	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:NE8FUmBNfYjfgniR7N8UDQ7jbBE	false	sufficient binding region:168-256	sufficient binding region:338-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:E9Q4Y4	uniprotkb:Q64702-1	intact:EBI-16110918|ensembl:ENSMUSP00000025425	intact:EBI-16110971|ensembl:ENSMUSP00000026858	psi-mi:e9q4y4_mouse(display_long)|uniprotkb:Cep192(gene name)|psi-mi:Cep192(display_short)	psi-mi:q64702-1(display_long)|uniprotkb:Plk4(gene name)|psi-mi:Plk4(display_short)|uniprotkb:Sak(gene name synonym)|uniprotkb:Stk18(gene name synonym)|uniprotkb:Sak-a(isoform synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Polo-like kinase 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16110982|imex:IM-23115-6|dip:DIP-197154E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000024542(gene)|ensembl:ENSMUST00000025425(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_081832.1|dip:DIP-61008N	intact:EBI-2552433(isoform-parent)|ensembl:ENSMUSG00000025758(gene)|ensembl:ENSMUST00000026858(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:xunbTiymnpjmUcri1DATiSH61XY10090	rogid:L1/nN7/3X379zeA2OE3rfje+Cvc10090	rigid:Z7u3xT0OyaRZXu9B8nHyvQII0zs	false	sufficient binding region:168-256|glutathione s tranferase tag:n-n	maltose binding protein tag:?-?|sufficient binding region:557-770|mutation increasing interaction strength:566-566,564-564|mutation increasing interaction strength:660-660|mutation decreasing interaction strength:672-672|mutation decreasing interaction strength:693-693|mutation decreasing interaction strength:767-767,766-766	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GT24	uniprotkb:Q9GT24	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111026|imex:IM-23115-7|dip:DIP-197146E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:7a/qN2tgp6RDCawIDAj+XmGAPBc	false	sufficient binding region:338-564	sufficient binding region:338-564	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O97143	uniprotkb:O97143	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111044|imex:IM-23115-8|dip:DIP-190052E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:yf3vxL4FBHd9SHB4v6h+pvw7K/0	false	sufficient binding region:383-601	sufficient binding region:383-601	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GT24	uniprotkb:Q9GT24	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111102|imex:IM-23115-11|dip:DIP-197146E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:7a/qN2tgp6RDCawIDAj+XmGAPBc	false	sufficient binding region:338-564	sufficient binding region:338-564	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O97143	uniprotkb:O97143	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111083|imex:IM-23115-10|dip:DIP-190052E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:yf3vxL4FBHd9SHB4v6h+pvw7K/0	false	sufficient binding region:383-601	sufficient binding region:383-601	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2AUM9	uniprotkb:O97143	intact:EBI-2554268|ensembl:ENSMUSP00000087208|uniprotkb:Q69ZV8|uniprotkb:Q8R0X1	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:ce152_mouse(display_long)|uniprotkb:Cep152(gene name)|psi-mi:Cep152(display_short)|uniprotkb:Kiaa0912(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111062|imex:IM-23115-9|dip:DIP-197151E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074560.1|ensembl:ENSMUSG00000068394(gene)|ensembl:ENSMUST00000089776(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0030030"(cell projection organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0019901"(protein kinase binding)|interpro:IPR029598|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|dip:DIP-56915N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:CDwAjK9qYpqP38Hfg/Z7ZlbeMqA10090	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:VGy75odVlHsNVpjt964KumUvczk	false	sufficient binding region:1-60	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111120|imex:IM-23115-12|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	sufficient binding region:11-44	sufficient binding region:338-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O97143	uniprotkb:O97143	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111141|imex:IM-23115-13|dip:DIP-190052E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:yf3vxL4FBHd9SHB4v6h+pvw7K/0	false	sufficient binding region:383-601	sufficient binding region:383-601	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:O97143	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111159|imex:IM-23115-14|dip:DIP-197150E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:Kg7NHve7ks7epM6uxMBNC5H07ek	false	sufficient binding region:11-44	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111180|imex:IM-23115-15|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	sufficient binding region:1-424|mutation disrupting interaction strength:19-19,18-18,16-16,15-15,12-12|mutation disrupting interaction strength:43-43,42-42,41-41,40-40,38-38	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111213|imex:IM-23115-16|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	sufficient binding region:1-46|maltose binding protein tag:n-n|mutation disrupting interaction strength:19-19,18-18,16-16,15-15,12-12|mutation decreasing interaction strength:36-36,34-34,28-28,26-26|mutation decreasing interaction strength:43-43,42-42,41-41,40-40,38-38	sufficient binding region:338-564|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O97143	uniprotkb:O97143	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111259|imex:IM-23115-17|dip:DIP-190052E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:yf3vxL4FBHd9SHB4v6h+pvw7K/0	false	sufficient binding region:383-601	sufficient binding region:383-601	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VNE4	uniprotkb:O97143	intact:EBI-108604|uniprotkb:Q7YTY4|ensemblmetazoa:FBpp0078392	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:q9vne4_drome(display_long)|uniprotkb:DmAsl(gene name synonym)|uniprotkb:asl(gene name)|psi-mi:asl(display_short)|uniprotkb:CG2919(orf name)|uniprotkb:ASL(gene name synonym)|uniprotkb:Asl(gene name synonym)|uniprotkb:Dmel\CG2919(gene name synonym)|uniprotkb:mecD(gene name synonym)|uniprotkb:sdu(gene name synonym)|uniprotkb:Dmel_CG2919(orf name)|uniprotkb:Cep152(gene name synonym)|uniprotkb:MecD(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111277|imex:IM-23115-18|dip:DIP-188230E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649557.2|flybase:FBgn0261004|dip:DIP-59503N|ensemblmetazoa:FBgn0261004(gene)|ensemblmetazoa:FBtr0078743(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007338"(single fertilization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0036064"(ciliary basal body)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1905515"(non-motile cilium assembly)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6PZMMJBBhXtp8MaXHx9klNTsnig7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:5dVig8qkRcvsqdw4fxmsKsiWovA	false	sufficient binding region:21-60|maltose binding protein tag:n-n	sufficient binding region:383-601|his tag:n-n|mutation disrupting interaction strength:490-490|mutation decreasing interaction strength:498-498|mutation decreasing interaction strength:510-510|mutation decreasing interaction strength:523-523|mutation decreasing interaction strength:595-595,594-594	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111318|imex:IM-23115-19|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	maltose binding protein tag:n-n|sufficient binding region:1-46	sufficient binding region:338-564|his tag:n-n|mutation disrupting interaction strength:500-500|mutation disrupting interaction strength:491-491,489-489|mutation decreasing interaction strength:470-470|mutation disrupting interaction strength:471-471,470-470|mutation decreasing interaction strength:471-471|mutation disrupting interaction strength:463-463|mutation decreasing interaction strength:454-454	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:E9Q4Y4	uniprotkb:O97143	intact:EBI-16110918|ensembl:ENSMUSP00000025425	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:e9q4y4_mouse(display_long)|uniprotkb:Cep192(gene name)|psi-mi:Cep192(display_short)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111365|imex:IM-23115-20|dip:DIP-197152E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000024542(gene)|ensembl:ENSMUST00000025425(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_081832.1|dip:DIP-61008N	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:xunbTiymnpjmUcri1DATiSH61XY10090	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:GUuYcY4EW8c73B4AGSsjrHRK3Vs	false	sufficient binding region:168-256	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VNE4	uniprotkb:O97143	intact:EBI-108604|uniprotkb:Q7YTY4|ensemblmetazoa:FBpp0078392	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:q9vne4_drome(display_long)|uniprotkb:DmAsl(gene name synonym)|uniprotkb:asl(gene name)|psi-mi:asl(display_short)|uniprotkb:CG2919(orf name)|uniprotkb:ASL(gene name synonym)|uniprotkb:Asl(gene name synonym)|uniprotkb:Dmel\CG2919(gene name synonym)|uniprotkb:mecD(gene name synonym)|uniprotkb:sdu(gene name synonym)|uniprotkb:Dmel_CG2919(orf name)|uniprotkb:Cep152(gene name synonym)|uniprotkb:MecD(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111386|imex:IM-23115-21|dip:DIP-188230E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649557.2|flybase:FBgn0261004|dip:DIP-59503N|ensemblmetazoa:FBgn0261004(gene)|ensemblmetazoa:FBtr0078743(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007338"(single fertilization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0036064"(ciliary basal body)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1905515"(non-motile cilium assembly)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6PZMMJBBhXtp8MaXHx9klNTsnig7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:5dVig8qkRcvsqdw4fxmsKsiWovA	false	sufficient binding region:21-60	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VNE4	uniprotkb:O97143	intact:EBI-108604|uniprotkb:Q7YTY4|ensemblmetazoa:FBpp0078392	intact:EBI-162366|uniprotkb:Q86NL8|ensemblmetazoa:FBpp0078042	psi-mi:q9vne4_drome(display_long)|uniprotkb:DmAsl(gene name synonym)|uniprotkb:asl(gene name)|psi-mi:asl(display_short)|uniprotkb:CG2919(orf name)|uniprotkb:ASL(gene name synonym)|uniprotkb:Asl(gene name synonym)|uniprotkb:Dmel\CG2919(gene name synonym)|uniprotkb:mecD(gene name synonym)|uniprotkb:sdu(gene name synonym)|uniprotkb:Dmel_CG2919(orf name)|uniprotkb:Cep152(gene name synonym)|uniprotkb:MecD(gene name synonym)	psi-mi:plk4_drome(display_long)|uniprotkb:SAK(gene name)|psi-mi:SAK(display_short)|uniprotkb:CG7186(orf name)|uniprotkb:Polo-like kinase 4(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAK(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111407|imex:IM-23115-22|dip:DIP-188230E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649557.2|flybase:FBgn0261004|dip:DIP-59503N|ensemblmetazoa:FBgn0261004(gene)|ensemblmetazoa:FBtr0078743(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007338"(single fertilization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0036064"(ciliary basal body)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1905515"(non-motile cilium assembly)	refseq:NP_649324.1|flybase:FBgn0026371|ensemblmetazoa:FBgn0026371(gene)|ensemblmetazoa:FBtr0078387(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035186"(syncytial blastoderm mitotic cell cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033696|interpro:IPR033698|interpro:IPR033699|interpro:IPR033700|rcsb pdb:4G7N|rcsb pdb:4NK7|rcsb pdb:5LHX|dip:DIP-49071N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6PZMMJBBhXtp8MaXHx9klNTsnig7227	rogid:79lsmHI1AKypIeTYWs23Z5ICJpA7227	rigid:5dVig8qkRcvsqdw4fxmsKsiWovA	false	sufficient binding region:21-60	sufficient binding region:383-601	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91870	uniprotkb:Q9GT24	intact:EBI-320962|ensemblmetazoa:F32H2.3.1|ensemblmetazoa:F32H2.3.2	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:spd2_caeel(display_long)|uniprotkb:F32H2.3(orf name)|uniprotkb:spd-2(gene name)|psi-mi:spd-2(display_short)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111428|imex:IM-23115-23|dip:DIP-197147E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_492414.1|wormbase:F32H2.3|ensemblmetazoa:F32H2.3.1(transcript)|ensemblmetazoa:F32H2.3.2(transcript)|ensemblmetazoa:WBGene00004953(gene)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0019901"(protein kinase binding)|go:"GO:0040025"(vulval development)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|dip:DIP-25500N	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:GBGtZRHVbrFLFhWQy/m9+L17Etk6239	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:ptCWpcDZ9cFoR3PWP0JVGX1gUFw	false	sufficient binding region:1-147	sufficient binding region:338-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64702-1	uniprotkb:A2AUM9	intact:EBI-16110971|ensembl:ENSMUSP00000026858	intact:EBI-2554268|ensembl:ENSMUSP00000087208|uniprotkb:Q69ZV8|uniprotkb:Q8R0X1	psi-mi:q64702-1(display_long)|uniprotkb:Plk4(gene name)|psi-mi:Plk4(display_short)|uniprotkb:Sak(gene name synonym)|uniprotkb:Stk18(gene name synonym)|uniprotkb:Sak-a(isoform synonym)|uniprotkb:Serine/threonine-protein kinase 18(gene name synonym)|uniprotkb:Serine/threonine-protein kinase Sak(gene name synonym)|uniprotkb:Polo-like kinase 4(gene name synonym)	psi-mi:ce152_mouse(display_long)|uniprotkb:Cep152(gene name)|psi-mi:Cep152(display_short)|uniprotkb:Kiaa0912(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111449|imex:IM-23115-24|dip:DIP-197153E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2552433(isoform-parent)|ensembl:ENSMUSG00000025758(gene)|ensembl:ENSMUST00000026858(transcript)	refseq:NP_001074560.1|ensembl:ENSMUSG00000068394(gene)|ensembl:ENSMUST00000089776(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0030030"(cell projection organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|go:"GO:0019901"(protein kinase binding)|interpro:IPR029598|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|dip:DIP-56915N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:L1/nN7/3X379zeA2OE3rfje+Cvc10090	rogid:CDwAjK9qYpqP38Hfg/Z7ZlbeMqA10090	rigid:27LRP83uFfZ5SKDzGqwMgOwVV7Y	false	sufficient binding region:557-770|maltose binding protein tag:?-?|mutation decreasing interaction strength:652-652|mutation increasing interaction strength:569-569,568-568|mutation decreasing interaction strength:660-660|mutation decreasing interaction strength:672-672|mutation decreasing interaction strength:693-693|mutation decreasing interaction strength:767-767,766-766	sufficient binding region:1-60|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VNE4	uniprotkb:Q9GT24	intact:EBI-108604|uniprotkb:Q7YTY4|ensemblmetazoa:FBpp0078392	intact:EBI-323555|uniprotkb:O01903|ensemblmetazoa:F59E12.2.1|ensemblmetazoa:F59E12.2.2	psi-mi:q9vne4_drome(display_long)|uniprotkb:DmAsl(gene name synonym)|uniprotkb:asl(gene name)|psi-mi:asl(display_short)|uniprotkb:CG2919(orf name)|uniprotkb:ASL(gene name synonym)|uniprotkb:Asl(gene name synonym)|uniprotkb:Dmel\CG2919(gene name synonym)|uniprotkb:mecD(gene name synonym)|uniprotkb:sdu(gene name synonym)|uniprotkb:Dmel_CG2919(orf name)|uniprotkb:Cep152(gene name synonym)|uniprotkb:MecD(gene name synonym)	psi-mi:zyg1_caeel(display_long)|uniprotkb:zyg-1(gene name)|psi-mi:zyg-1(display_short)|uniprotkb:F59E12.2(orf name)|uniprotkb:Zygote defective protein 1(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Shimanovskaya et al. (2014)	pubmed:24980795|doi:"https://doi.org/10.1016/j.str.2014.05.009"|imex:IM-23115	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16111496|imex:IM-23115-25|dip:DIP-197148E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_649557.2|flybase:FBgn0261004|dip:DIP-59503N|ensemblmetazoa:FBgn0261004(gene)|ensemblmetazoa:FBtr0078743(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007099"(centriole replication)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007338"(single fertilization)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0036064"(ciliary basal body)|go:"GO:1903723"(negative regulation of centriole elongation)|go:"GO:1905515"(non-motile cilium assembly)	refseq:NP_495103.1|wormbase:F59E12.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008104"(protein localization)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009794"(regulation of mitotic cell cycle, embryonic)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010825"(positive regulation of centrosome duplication)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045977"(positive regulation of mitotic cell cycle, embryonic)|go:"GO:0051225"(spindle assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090268"(activation of mitotic cell cycle spindle assembly checkpoint)|ensemblmetazoa:F59E12.2.1(transcript)|ensemblmetazoa:F59E12.2.2(transcript)|ensemblmetazoa:WBGene00006988(gene)|go:"GO:0000003"(reproduction)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0106311"|go:"GO:1903436"(regulation of mitotic cytokinetic process)|go:"GO:1904779"(regulation of protein localization to centrosome)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR040733|interpro:IPR040734|rcsb pdb:4NKB|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-24892N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:6PZMMJBBhXtp8MaXHx9klNTsnig7227	rogid:bW56U+tOCdP8UXKTudspR9Oi4/Q6239	rigid:TVw+hgTIKZQaCXVPsu054Meu1X0	false	sufficient binding region:21-60	sufficient binding region:338-564	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)