#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63098 uniprotkb:Q08209-1 intact:EBI-915984|uniprotkb:B5MDU4|uniprotkb:P06705|uniprotkb:P15117|uniprotkb:Q08044|uniprotkb:Q53SL0|uniprotkb:B2RC10|ensembl:ENSP00000234310 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:canb1_human(display_long)|uniprotkb:PPP3R1(gene name)|psi-mi:PPP3R1(display_short)|uniprotkb:CNA2(gene name synonym)|uniprotkb:CNB(gene name synonym)|uniprotkb:Protein phosphatase 2B regulatory subunit 1(gene name synonym)|uniprotkb:Protein phosphatase 3 regulatory subunit B alpha isoform 1(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110452|imex:IM-23114-1|dip:DIP-10973E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000936.1|dip:DIP-6096N|ensembl:ENSG00000221823(gene)|ensembl:ENST00000234310(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007507"(heart development)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042383"(sarcolemma)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015757(Calcineurin B protein)|interpro:IPR018247|mint:P63098|rcsb pdb:1AUI|rcsb pdb:1M63|rcsb pdb:1MF8|rcsb pdb:2P6B|rcsb pdb:3LL8|rcsb pdb:4F0Z|rcsb pdb:4OR9|rcsb pdb:4ORA|rcsb pdb:4ORC|rcsb pdb:5SVE|rcsb pdb:6NUC|rcsb pdb:6NUF|rcsb pdb:6NUU|reactome:R-HSA-111447|reactome:R-HSA-180024|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763 ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:RqM4Q9x8EiLx7CyoF2Rvjl5RddM9606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:TBMBRaQOIBs3sHBRkxKucLjJI8U false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95644 uniprotkb:Q08209-1 intact:EBI-6907210|uniprotkb:Q12865|uniprotkb:Q15793|uniprotkb:B5B2M4|uniprotkb:B5B2M5|uniprotkb:B5B2M6|uniprotkb:B5B2M7|uniprotkb:B5B2M8|uniprotkb:B5B2M9|uniprotkb:B5B2N1|uniprotkb:Q2M1S3|ensembl:ENSP00000389377 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:nfac1_human(display_long)|uniprotkb:NFATC1(gene name)|psi-mi:NFATC1(display_short)|uniprotkb:NFAT2(gene name synonym)|uniprotkb:NFATC(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110469|imex:IM-23114-2|dip:DIP-190429E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006153.2|refseq:NP_765975.1|refseq:NP_765976.1|refseq:NP_765977.1|refseq:NP_765978.1|refseq:NP_001265598.1|refseq:NP_001265599.1|refseq:NP_001265601.1|refseq:NP_001265602.1|refseq:NP_001265604.1|dip:DIP-44311N|ensembl:ENSG00000131196(gene)|ensembl:ENST00000427363(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR032397|interpro:IPR037059|mint:O95644|rcsb pdb:1A66|rcsb pdb:1NFA|rcsb pdb:5SVE|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763 ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:ighU5P59Gv8yTk6lwwm/Ohy3FdY9606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:WlFid2J8qaCRsk8chKLrGhKD+wI false sufficient binding region:384-398 sufficient binding region:2-347 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95644 uniprotkb:Q08209-1 intact:EBI-6907210|uniprotkb:Q12865|uniprotkb:Q15793|uniprotkb:B5B2M4|uniprotkb:B5B2M5|uniprotkb:B5B2M6|uniprotkb:B5B2M7|uniprotkb:B5B2M8|uniprotkb:B5B2M9|uniprotkb:B5B2N1|uniprotkb:Q2M1S3|ensembl:ENSP00000389377 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:nfac1_human(display_long)|uniprotkb:NFATC1(gene name)|psi-mi:NFATC1(display_short)|uniprotkb:NFAT2(gene name synonym)|uniprotkb:NFATC(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110490|imex:IM-23114-3|dip:DIP-190429E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006153.2|refseq:NP_765975.1|refseq:NP_765976.1|refseq:NP_765977.1|refseq:NP_765978.1|refseq:NP_001265598.1|refseq:NP_001265599.1|refseq:NP_001265601.1|refseq:NP_001265602.1|refseq:NP_001265604.1|dip:DIP-44311N|ensembl:ENSG00000131196(gene)|ensembl:ENST00000427363(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR032397|interpro:IPR037059|mint:O95644|rcsb pdb:1A66|rcsb pdb:1NFA|rcsb pdb:5SVE|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763 ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:ighU5P59Gv8yTk6lwwm/Ohy3FdY9606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:WlFid2J8qaCRsk8chKLrGhKD+wI false sufficient binding region:384-398 sufficient binding region:2-347 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13469 uniprotkb:Q08209-1 intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110511|imex:IM-23114-4|dip:DIP-197145E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:mE8wRSmNb/6Qqg2m0aYksabbJLk false sufficient binding region:100-130|fluorescein isothiocyanate label:c-c sufficient binding region:2-347 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13469 uniprotkb:Q08209-1 intact:EBI-716258|uniprotkb:B5B2N9|uniprotkb:Q13468|uniprotkb:Q5TFW7|uniprotkb:Q5TFW8|uniprotkb:Q9NPX6|uniprotkb:Q9NQH3|uniprotkb:Q9UJR2|uniprotkb:B5B2P0|uniprotkb:B5B2N8|ensembl:ENSP00000379330|uniprotkb:B5B2P2|uniprotkb:B5B2P3 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:nfac2_human(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:NFATC2(gene name)|psi-mi:NFATC2(display_short)|uniprotkb:NFAT1(gene name synonym)|uniprotkb:NFATP(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110534|imex:IM-23114-5|dip:DIP-197145E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001245221.1|refseq:NP_036472.2|refseq:NP_775114.1|refseq:NP_001245223.1|refseq:NP_001245225.1|refseq:NP_001129493.1|ensembl:ENSG00000101096(gene)|ensembl:ENST00000396009(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042493"|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR037059|rcsb pdb:1A02|rcsb pdb:1OWR|rcsb pdb:1P7H|go:"GO:1990904"(ribonucleoprotein complex)|rcsb pdb:1PZU|rcsb pdb:1S9K|rcsb pdb:2AS5|rcsb pdb:2O93|interpro:IPR002909(Cell surface receptor IPT/TIG)|rcsb pdb:3QRF|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-5607763|reactome:R-HSA-8877330|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|dip:DIP-27630N ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:SNvCfCooUb7MH1xO0prmM4jv+o49606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:mE8wRSmNb/6Qqg2m0aYksabbJLk false sufficient binding region:100-130 sufficient binding region:2-347 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95644 uniprotkb:Q08209-1 intact:EBI-6907210|uniprotkb:Q12865|uniprotkb:Q15793|uniprotkb:B5B2M4|uniprotkb:B5B2M5|uniprotkb:B5B2M6|uniprotkb:B5B2M7|uniprotkb:B5B2M8|uniprotkb:B5B2M9|uniprotkb:B5B2N1|uniprotkb:Q2M1S3|ensembl:ENSP00000389377 intact:EBI-15637215|ensembl:ENSP00000378323 psi-mi:nfac1_human(display_long)|uniprotkb:NFATC1(gene name)|psi-mi:NFATC1(display_short)|uniprotkb:NFAT2(gene name synonym)|uniprotkb:NFATC(gene name synonym)|uniprotkb:NFAT transcription complex cytosolic component(gene name synonym) psi-mi:q08209-1(display_long)|uniprotkb:PPP3CA(gene name)|psi-mi:PPP3CA(display_short)|uniprotkb:CALNA(gene name synonym)|uniprotkb:CNA(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Gal et al. (2014) pubmed:24954618|doi:10.1016/j.str.2014.05.006|imex:IM-23114 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110555|imex:IM-23114-6|dip:DIP-190429E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006153.2|refseq:NP_765975.1|refseq:NP_765976.1|refseq:NP_765977.1|refseq:NP_765978.1|refseq:NP_001265598.1|refseq:NP_001265599.1|refseq:NP_001265601.1|refseq:NP_001265602.1|refseq:NP_001265604.1|dip:DIP-44311N|ensembl:ENSG00000131196(gene)|ensembl:ENST00000427363(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015647(Nuclear factor of activated T-cells 1)|interpro:IPR032397|interpro:IPR037059|mint:O95644|rcsb pdb:1A66|rcsb pdb:1NFA|rcsb pdb:5SVE|reactome:R-HSA-2025928|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-5607763 ensembl:ENSG00000138814(gene)|ensembl:ENST00000394854(transcript)|intact:EBI-352922(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:ighU5P59Gv8yTk6lwwm/Ohy3FdY9606 rogid:kYtl+Yk39rbcDp5vIjH8WLsZysU9606 rigid:WlFid2J8qaCRsk8chKLrGhKD+wI false sufficient binding region:384-398|fluorescein isothiocyanate label:c-c sufficient binding region:2-347 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)