#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P05067-PRO_0000000093 uniprotkb:Q5JRX3-1 intact:EBI-2431589|intact:EBI-20772365 intact:EBI-16109799|ensembl:ENSP00000224949 psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:q5jrx3-1(display_long)|uniprotkb:PREP(gene name synonym)|uniprotkb:PITRM1(gene name)|psi-mi:PITRM1(display_short)|uniprotkb:KIAA1104(gene name synonym)|uniprotkb:MP1(gene name synonym)|uniprotkb:Pitrilysin metalloproteinase 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) King et al. (2014) pubmed:24931469|doi:10.1016/j.str.2014.05.003|imex:IM-23113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16109808|imex:IM-23113-1|dip:DIP-197144E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-77613(chain-parent) intact:EBI-2432778(isoform-parent)|ensembl:ENSG00000107959(gene)|ensembl:ENST00000224949(transcript) psi-mi:"MI:0465"(dip) chain-seq-start:672|chain-seq-end:711 - dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2018/09/18 rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606 rogid:1kEY/XJB5fwgNRoM9u9ZGT+VrS09606 rigid:AR6VEEyOYROskQ5HZQB18anCRrY false - sufficient binding region:33-1037 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P05067-PRO_0000000093 uniprotkb:Q5JRX3-1 intact:EBI-2431589|intact:EBI-20772365 intact:EBI-16109799|ensembl:ENSP00000224949 psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:q5jrx3-1(display_long)|uniprotkb:PREP(gene name synonym)|uniprotkb:PITRM1(gene name)|psi-mi:PITRM1(display_short)|uniprotkb:KIAA1104(gene name synonym)|uniprotkb:MP1(gene name synonym)|uniprotkb:Pitrilysin metalloproteinase 1(gene name synonym) psi-mi:"MI:0435"(protease assay) King et al. (2014) pubmed:24931469|doi:10.1016/j.str.2014.05.003|imex:IM-23113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0465"(DIP) intact:EBI-16109827|imex:IM-23113-2|dip:DIP-197144E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-77613(chain-parent) intact:EBI-2432778(isoform-parent)|ensembl:ENSG00000107959(gene)|ensembl:ENST00000224949(transcript) psi-mi:"MI:0465"(dip) chain-seq-start:672|chain-seq-end:711 - dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2018/09/18 rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606 rogid:1kEY/XJB5fwgNRoM9u9ZGT+VrS09606 rigid:AR6VEEyOYROskQ5HZQB18anCRrY false - sufficient binding region:33-1037 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P05067-PRO_0000000093 uniprotkb:Q5JRX3-1 intact:EBI-2431589|intact:EBI-20772365 intact:EBI-16109799|ensembl:ENSP00000224949 psi-mi:p05067-pro_0000000093(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:q5jrx3-1(display_long)|uniprotkb:PREP(gene name synonym)|uniprotkb:PITRM1(gene name)|psi-mi:PITRM1(display_short)|uniprotkb:KIAA1104(gene name synonym)|uniprotkb:MP1(gene name synonym)|uniprotkb:Pitrilysin metalloproteinase 1(gene name synonym) psi-mi:"MI:0826"(x ray scattering) King et al. (2014) pubmed:24931469|doi:10.1016/j.str.2014.05.003|imex:IM-23113 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16109846|imex:IM-23113-3|dip:DIP-197144E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-77613(chain-parent) intact:EBI-2432778(isoform-parent)|ensembl:ENSG00000107959(gene)|ensembl:ENST00000224949(transcript) psi-mi:"MI:0465"(dip) chain-seq-start:672|chain-seq-end:711 - dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2018/09/18 rogid:1Fb4Lc4fYdV85pxpVo7LvPBbD1o9606 rogid:1kEY/XJB5fwgNRoM9u9ZGT+VrS09606 rigid:AR6VEEyOYROskQ5HZQB18anCRrY false - sufficient binding region:33-1037 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)