#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UKU9	uniprotkb:Q8N423	intact:EBI-15485893|ensembl:ENSP00000362524|uniprotkb:Q5JT58|uniprotkb:Q8NCH7	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	psi-mi:angl2_human(display_long)|uniprotkb:ANGPTL2(gene name)|psi-mi:ANGPTL2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:UNQ170/PRO196(orf name)|uniprotkb:Angiopoietin-like protein 2(gene name synonym)	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Deng et al. (2014)	pubmed:24899623|imex:IM-25820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485887|imex:IM-25820-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136859(gene)|ensembl:ENST00000373425(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:6Y41|refseq:NP_036230.1|dip:DIP-59886N	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:1C, 3 A-G|comment:Angptl2 binds to LILRB2 with a significantly greater affinity than HLA-G|comment:LILRB2  Ig1 and Ig2 domains displayed about 50%  of the maximal binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/25	rogid:ubcaYrtyccJ2QC57q/uRjpDrZk09606	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rigid:9FE/yebtROHUkP/gzLdhWLP+jTU	false	flag tag:c-c	green fluorescent protein tag:c-c|mutation decreasing interaction strength:92-97,99-100|sufficient binding region:27..27-229..229|mutation with no effect:92-92|mutation increasing interaction strength:93-93|mutation decreasing interaction strength:94-94|mutation decreasing interaction strength:95-95|mutation decreasing interaction strength:96-96|mutation with no effect:97-97|mutation decreasing interaction strength:100-100|mutation with no effect:392-392|mutation with no effect:393-393|mutation decreasing interaction strength:394-394|mutation disrupting interaction strength:96-96,392-392|mutation decreasing interaction strength:96-96,393-393|mutation disrupting interaction strength:96-96,394-394|mutation decreasing interaction strength:59-59,61-61|mutation with no effect:90-90,200-200,202-202,205-205|mutation with no effect:99-99|mutation decreasing interaction strength:59-59,61-61,90-90,200-200,202-202,205-205	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P17693	uniprotkb:Q8N423	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Deng et al. (2014)	pubmed:24899623|imex:IM-25820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15486108|imex:IM-25820-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:1C, 3G|comment:Angptl2 binds to LILRB2 with a significantly greater affinity than HLA-G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/25	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rigid:yT+XLgcf3zp0zEFT9a+PU7aLgkI	false	flag tag:c-c|sufficient binding region:25..25-308..308	green fluorescent protein tag:c-c|mutation disrupting interaction strength:59-59,61-61|mutation decreasing interaction strength:92-92|mutation decreasing interaction strength:93-93|mutation disrupting interaction strength:94-94|mutation decreasing interaction strength:95-95|mutation decreasing interaction strength:96-96|mutation decreasing interaction strength:97-97|mutation decreasing interaction strength:100-100|mutation decreasing interaction strength:392-392|mutation decreasing interaction strength:393-393|mutation decreasing interaction strength:394-394|mutation disrupting interaction strength:96-96,392-392|mutation disrupting interaction strength:96-96,393-393|mutation disrupting interaction strength:96-96,394-394|mutation disrupting interaction strength:59-59,61-61,90-90,200-200,202-202,205-205|mutation with no effect:90-90,200-200,202-202,205-205|mutation decreasing interaction strength:99-99	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q86XS5	uniprotkb:Q8N423	intact:EBI-15485927|ensembl:ENSP00000335255|uniprotkb:A8K658|uniprotkb:Q86VR9	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	psi-mi:angl5_human(display_long)|uniprotkb:ANGPTL5(gene name)|psi-mi:ANGPTL5(display_short)|uniprotkb:UNQ5795/PRO19600(orf name)|uniprotkb:Angiopoietin-like protein 5(gene name synonym)	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Deng et al. (2014)	pubmed:24899623|imex:IM-25820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15486190|imex:IM-25820-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000187151(gene)|ensembl:ENST00000334289(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|refseq:NP_835228.2|dip:DIP-59887N	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	-	-	-	figure legend:Supp fig 1B, 3G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/25	rogid:tJTu5vrDyarClOwuVeesYvc5K+Q9606	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rigid:O+xvLJlbgK5QB1cUAOIot4PWffs	false	flag tag:c-c	green fluorescent protein tag:c-c|mutation with no effect:59-59,61-61|mutation decreasing interaction strength:92-92|mutation decreasing interaction strength:93-93|mutation disrupting interaction strength:94-94|mutation decreasing interaction strength:95-95|mutation decreasing interaction strength:96-96|mutation with no effect:97-97|mutation decreasing interaction strength:100-100|mutation decreasing interaction strength:392-392|mutation decreasing interaction strength:393-393|mutation decreasing interaction strength:394-394|mutation disrupting interaction strength:96-96,392-392|mutation disrupting interaction strength:96-96,393-393|mutation disrupting interaction strength:96-96,394-394|mutation decreasing interaction strength:59-59,61-61,90-90,200-200,202-202,205-205|mutation decreasing interaction strength:90-90,200-200,202-202,205-205|mutation decreasing interaction strength:99-99	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N423	uniprotkb:Q9UKU9	intact:EBI-2816428|uniprotkb:Q8NHJ7|uniprotkb:Q8NHJ8|uniprotkb:O75017|uniprotkb:A8MU67|uniprotkb:C9JF29|ensembl:ENSP00000319960|ensembl:ENSP00000375626|ensembl:ENSP00000375628|ensembl:ENSP00000375629|ensembl:ENSP00000410117|ensembl:ENSP00000480302|ensembl:ENSP00000481208|ensembl:ENSP00000482933|ensembl:ENSP00000483553|ensembl:ENSP00000484373	intact:EBI-15485893|ensembl:ENSP00000362524|uniprotkb:Q5JT58|uniprotkb:Q8NCH7	psi-mi:lirb2_human(display_long)|uniprotkb:LILRB2(gene name)|psi-mi:LILRB2(display_short)|uniprotkb:ILT4(gene name synonym)|uniprotkb:LIR2(gene name synonym)|uniprotkb:MIR10(gene name synonym)|uniprotkb:CD85 antigen-like family member D(gene name synonym)|uniprotkb:Immunoglobulin-like transcript 4(gene name synonym)|uniprotkb:Monocyte/macrophage immunoglobulin-like receptor 10(gene name synonym)	psi-mi:angl2_human(display_long)|uniprotkb:ANGPTL2(gene name)|psi-mi:ANGPTL2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:UNQ170/PRO196(orf name)|uniprotkb:Angiopoietin-like protein 2(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	Deng et al. (2014)	pubmed:24899623|imex:IM-25820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15486249|imex:IM-25820-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59888N|ensembl:ENSG00000131042(gene)|ensembl:ENSG00000274513(gene)|ensembl:ENSG00000275463(gene)|ensembl:ENSG00000276146(gene)|ensembl:ENST00000314446(transcript)|ensembl:ENST00000391746(transcript)|ensembl:ENST00000391748(transcript)|ensembl:ENST00000391749(transcript)|ensembl:ENST00000434421(transcript)|ensembl:ENST00000610886(transcript)|ensembl:ENST00000617341(transcript)|ensembl:ENST00000617886(transcript)|ensembl:ENST00000618392(transcript)|ensembl:ENST00000618705(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002578"(negative regulation of antigen processing and presentation)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007611"(learning or memory)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0023025"(MHC class Ib protein complex binding)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:0032396"(inhibitory MHC class I receptor activity)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0140105"(interleukin-10-mediated signaling pathway)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1905875"(negative regulation of postsynaptic density organization)|go:"GO:2000524"(negative regulation of T cell costimulation)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DYP|rcsb pdb:2GW5|rcsb pdb:4LLA|rcsb pdb:6AED|rcsb pdb:6BCS|reactome:R-HSA-198933|reactome:R-HSA-6798695	ensembl:ENSG00000136859(gene)|ensembl:ENST00000373425(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:6Y41|refseq:NP_036230.1|dip:DIP-59886N	-	-	-	figure legend:supp Fig 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/25	rogid:nFaZ5NEqw5u/3Du7Mi6fJpEQEdo9606	rogid:ubcaYrtyccJ2QC57q/uRjpDrZk09606	rigid:9FE/yebtROHUkP/gzLdhWLP+jTU	false	-	flag tag:c-c|sufficient binding region:76..76-206..206	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9UKU9	uniprotkb:Q9UKU9	intact:EBI-15485893|ensembl:ENSP00000362524|uniprotkb:Q5JT58|uniprotkb:Q8NCH7	intact:EBI-15485893|ensembl:ENSP00000362524|uniprotkb:Q5JT58|uniprotkb:Q8NCH7	psi-mi:angl2_human(display_long)|uniprotkb:ANGPTL2(gene name)|psi-mi:ANGPTL2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:UNQ170/PRO196(orf name)|uniprotkb:Angiopoietin-like protein 2(gene name synonym)	psi-mi:angl2_human(display_long)|uniprotkb:ANGPTL2(gene name)|psi-mi:ANGPTL2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:UNQ170/PRO196(orf name)|uniprotkb:Angiopoietin-like protein 2(gene name synonym)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Deng et al. (2014)	pubmed:24899623|imex:IM-25820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15485978|imex:IM-25820-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136859(gene)|ensembl:ENST00000373425(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:6Y41|refseq:NP_036230.1|dip:DIP-59886N	ensembl:ENSG00000136859(gene)|ensembl:ENST00000373425(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR036056|rcsb pdb:6Y41|refseq:NP_036230.1|dip:DIP-59886N	-	-	-	figure legend:1D|comment:The C terminal FBN domain only ran as a monomer.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/01	2017/07/24	rogid:ubcaYrtyccJ2QC57q/uRjpDrZk09606	rogid:ubcaYrtyccJ2QC57q/uRjpDrZk09606	rigid:BUIiXERDWWnB9kwFudZhVAyWJ8g	false	flag tag:c-c|sufficient binding region:76..76-206..206	flag tag:c-c|sufficient binding region:76..76-206..206	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)