#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9WTK7 uniprotkb:Q9CSB4 intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8 intact:EBI-16107395|ensembl:ENSMUSP00000074837|uniprotkb:Q5SV53 psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym) psi-mi:par3l_mouse(display_long)|uniprotkb:Pard3b(gene name)|psi-mi:Pard3b(display_short)|uniprotkb:Als2cr19(gene name synonym)|uniprotkb:Par3l(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog(gene name synonym)|uniprotkb:PAR3-beta(gene name synonym)|uniprotkb:Partitioning defective 3-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Huo et al. (2014) pubmed:24859006|doi:10.1038/ncb2969|imex:IM-22709 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16107421|imex:IM-22709-1|dip:DIP-196602E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N ensembl:ENSMUSG00000052062(gene)|ensembl:ENSMUST00000075374(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:1WG6|refseq:NP_001074519.2|dip:DIP-60855N psi-mi:"MI:0465"(dip) comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090 rogid:gmfj7hj5rRG/BQDvpARXslFfi/w10090 rigid:48AzP50COVYfPzR1C9ADWK9G1+0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WTK7 uniprotkb:Q9CSB4 intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8 intact:EBI-16107395|ensembl:ENSMUSP00000074837|uniprotkb:Q5SV53 psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym) psi-mi:par3l_mouse(display_long)|uniprotkb:Pard3b(gene name)|psi-mi:Pard3b(display_short)|uniprotkb:Als2cr19(gene name synonym)|uniprotkb:Par3l(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein homolog(gene name synonym)|uniprotkb:PAR3-beta(gene name synonym)|uniprotkb:Partitioning defective 3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Huo et al. (2014) pubmed:24859006|doi:10.1038/ncb2969|imex:IM-22709 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16107438|imex:IM-22709-2|dip:DIP-196602E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N ensembl:ENSMUSG00000052062(gene)|ensembl:ENSMUST00000075374(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008104"(protein localization)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021922|interpro:IPR036034|rcsb pdb:1WG6|refseq:NP_001074519.2|dip:DIP-60855N psi-mi:"MI:0465"(dip) comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090 rogid:gmfj7hj5rRG/BQDvpARXslFfi/w10090 rigid:48AzP50COVYfPzR1C9ADWK9G1+0 false - green fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WTK7 uniprotkb:Q8TEW8-1 intact:EBI-8627450|ensembl:ENSMUSP00000003152|uniprotkb:B3VBP0|intact:UNK-5558899|uniprotkb:Q3TAE0|uniprotkb:A0A2L1DGD8 intact:EBI-16107457|ensembl:ENSP00000385848 psi-mi:stk11_mouse(display_long)|uniprotkb:Liver kinase B1 homolog(gene name synonym)|uniprotkb:Stk11(gene name)|psi-mi:Stk11(display_short)|uniprotkb:Lkb1(gene name synonym) psi-mi:q8tew8-1(display_long)|uniprotkb:PARD3B(gene name)|psi-mi:PARD3B(display_short)|uniprotkb:ALS2CR19(gene name synonym)|uniprotkb:PAR3B(gene name synonym)|uniprotkb:PAR3L(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein(gene name synonym)|uniprotkb:PAR3-beta(gene name synonym)|uniprotkb:Partitioning defective 3-like protein(gene name synonym)|uniprotkb:Par3La(isoform synonym)|uniprotkb:a(isoform synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Huo et al. (2014) pubmed:24859006|doi:10.1038/ncb2969|imex:IM-22709 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16107471|imex:IM-22709-3|dip:DIP-196603E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000003068(gene)|ensembl:ENSMUST00000003152(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0010508"(positive regulation of autophagy)|refseq:NP_001288782.1|refseq:NP_001288783.1|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1904262"(negative regulation of TORC1 signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|reactome:R-MMU-380972|reactome:R-MMU-6804756|refseq:NP_035622.1|dip:DIP-60722N intact:EBI-2861929(isoform-parent)|ensembl:ENSG00000116117(gene)|ensembl:ENST00000406610(transcript) psi-mi:"MI:0465"(dip) comment:mint|function:"Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases (By similarity). Tumor suppressor" - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:nVr/eHdzmWH70LDqeSsLv5W7V4A10090 rogid:68iR8w+iTdxuwBYs+HGumldBFQs9606 rigid:Hmb2qvaDC2IHnD6TvpJIPU7eutA false - sufficient binding region:477-1205|sufficient binding region:321-597|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)