#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y3Q4	uniprotkb:Q9Y3Q4	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	intact:EBI-1753521|uniprotkb:Q9UMQ7|ensembl:ENSP00000261917	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:hcn4_human(display_long)|uniprotkb:HCN4(gene name)|psi-mi:HCN4(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Lolicato et al. (2014)	pubmed:24776929|doi:10.1038/nchembio.1521|imex:IM-22713	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16104479|imex:IM-22713-1|dip:DIP-196605E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	refseq:NP_005468.1|dip:DIP-52325N|ensembl:ENSG00000138622(gene)|ensembl:ENST00000261917(transcript)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0005222"(intracellular cAMP-activated cation channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0008015"(blood circulation)|go:"GO:0030552"(cAMP binding)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086015"(SA node cell action potential)|go:"GO:0086041"(voltage-gated potassium channel activity involved in SA node cell action potential depolarization)|go:"GO:0086046"(membrane depolarization during SA node cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098855"(HCN channel complex)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003938(Potassium channel, voltage-dependent, EAG/ELK/ERG)|interpro:IPR005821(Ion transport)|interpro:IPR013621(Ion transport N-terminal)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:2MNG|rcsb pdb:3OTF|rcsb pdb:3U11|rcsb pdb:4HBN|rcsb pdb:4KL1|rcsb pdb:4NVP|rcsb pdb:6GYN|rcsb pdb:6GYO|reactome:R-HSA-1296061	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	rogid:fmQO9MoGFEcs2VgwSsbosD7Uv1g9606	rigid:E2C1hyV9tum0SU9BpwbE9XC+Nrs	false	sufficient binding region:521-723	sufficient binding region:521-723	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)