#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61093 uniprotkb:Q61462 intact:EBI-6654585|ensembl:ENSMUSP00000015484 intact:EBI-15795776|ensembl:ENSMUSP00000017604|uniprotkb:Q3U820|uniprotkb:Q9CWB9|uniprotkb:Q9D2W2 psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:cy24a_mouse(display_long)|uniprotkb:Cyba(gene name)|psi-mi:Cyba(display_short)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:p22-phox(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16102739|imex:IM-22691-1|dip:DIP-196550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|ensembl:ENSMUSG00000006519(gene)|ensembl:ENSMUST00000017604(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001288213.1|refseq:NP_031832.2|dip:DIP-60456N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rogid:Sqox5aGM2G1TXSpKwI1o/tK103A10090 rigid:Esua5k6Fn5+hJkb7pP0qJVtiYU8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61093 uniprotkb:Q8BMT4 intact:EBI-6654585|ensembl:ENSMUSP00000015484 intact:EBI-16102695|ensembl:ENSMUSP00000097571|ensembl:ENSMUSP00000116388|ensembl:ENSMUSP00000119349|uniprotkb:Q3TIA8|uniprotkb:Q8BTT4|uniprotkb:Q8BUI7|uniprotkb:Q8BY16|uniprotkb:Q8R063 psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:lrc33_mouse(display_long)|uniprotkb:Negative regulator of reactive oxygen species(gene name synonym)|uniprotkb:Nrros(gene name)|psi-mi:Nrros(display_short)|uniprotkb:Lrrc33(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 33(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16102739|imex:IM-22691-1|dip:DIP-196550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N ensembl:ENSMUSG00000052384(gene)|ensembl:ENSMUST00000099991(transcript)|ensembl:ENSMUST00000126869(transcript)|ensembl:ENSMUST00000143682(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0036364"(transforming growth factor beta1 activation)|go:"GO:0050431"(transforming growth factor beta binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_001334110.1|refseq:NP_001334111.1|refseq:NP_666181.2|refseq:XP_006522137.1|refseq:XP_006522138.1|refseq:XP_006522139.1|refseq:XP_006522140.1|refseq:XP_017172451.1|dip:DIP-60840N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rogid:wKD0HBLc0vmoeUBsxhS/K7tMmlg10090 rigid:Esua5k6Fn5+hJkb7pP0qJVtiYU8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61093 uniprotkb:Q61462 intact:EBI-6654585|ensembl:ENSMUSP00000015484 intact:EBI-15795776|ensembl:ENSMUSP00000017604|uniprotkb:Q3U820|uniprotkb:Q9CWB9|uniprotkb:Q9D2W2 psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:cy24a_mouse(display_long)|uniprotkb:Cyba(gene name)|psi-mi:Cyba(display_short)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:p22-phox(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16102757|imex:IM-22691-2|dip:DIP-196550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|ensembl:ENSMUSG00000006519(gene)|ensembl:ENSMUST00000017604(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001288213.1|refseq:NP_031832.2|dip:DIP-60456N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/08 2017/08/10 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rogid:Sqox5aGM2G1TXSpKwI1o/tK103A10090 rigid:Esua5k6Fn5+hJkb7pP0qJVtiYU8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61093 uniprotkb:Q8BMT4 intact:EBI-6654585|ensembl:ENSMUSP00000015484 intact:EBI-16102695|ensembl:ENSMUSP00000097571|ensembl:ENSMUSP00000116388|ensembl:ENSMUSP00000119349|uniprotkb:Q3TIA8|uniprotkb:Q8BTT4|uniprotkb:Q8BUI7|uniprotkb:Q8BY16|uniprotkb:Q8R063 psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:lrc33_mouse(display_long)|uniprotkb:Negative regulator of reactive oxygen species(gene name synonym)|uniprotkb:Nrros(gene name)|psi-mi:Nrros(display_short)|uniprotkb:Lrrc33(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 33(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16102757|imex:IM-22691-2|dip:DIP-196550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N ensembl:ENSMUSG00000052384(gene)|ensembl:ENSMUST00000099991(transcript)|ensembl:ENSMUST00000126869(transcript)|ensembl:ENSMUST00000143682(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0036364"(transforming growth factor beta1 activation)|go:"GO:0050431"(transforming growth factor beta binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_001334110.1|refseq:NP_001334111.1|refseq:NP_666181.2|refseq:XP_006522137.1|refseq:XP_006522138.1|refseq:XP_006522139.1|refseq:XP_006522140.1|refseq:XP_017172451.1|dip:DIP-60840N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/08 2017/08/10 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rogid:wKD0HBLc0vmoeUBsxhS/K7tMmlg10090 rigid:Esua5k6Fn5+hJkb7pP0qJVtiYU8 false - flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BMT4 uniprotkb:Q61093 intact:EBI-16102695|ensembl:ENSMUSP00000097571|ensembl:ENSMUSP00000116388|ensembl:ENSMUSP00000119349|uniprotkb:Q3TIA8|uniprotkb:Q8BTT4|uniprotkb:Q8BUI7|uniprotkb:Q8BY16|uniprotkb:Q8R063 intact:EBI-6654585|ensembl:ENSMUSP00000015484 psi-mi:lrc33_mouse(display_long)|uniprotkb:Negative regulator of reactive oxygen species(gene name synonym)|uniprotkb:Nrros(gene name)|psi-mi:Nrros(display_short)|uniprotkb:Lrrc33(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 33(gene name synonym) psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16102777|imex:IM-22691-3|dip:DIP-196552E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000052384(gene)|ensembl:ENSMUST00000099991(transcript)|ensembl:ENSMUST00000126869(transcript)|ensembl:ENSMUST00000143682(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0036364"(transforming growth factor beta1 activation)|go:"GO:0050431"(transforming growth factor beta binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_001334110.1|refseq:NP_001334111.1|refseq:NP_666181.2|refseq:XP_006522137.1|refseq:XP_006522138.1|refseq:XP_006522139.1|refseq:XP_006522140.1|refseq:XP_017172451.1|dip:DIP-60840N ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/08 2017/08/10 rogid:wKD0HBLc0vmoeUBsxhS/K7tMmlg10090 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rigid:006P++Ge6LWAAiGpBm8P2KmLrrA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61462 uniprotkb:Q61093 intact:EBI-15795776|ensembl:ENSMUSP00000017604|uniprotkb:Q3U820|uniprotkb:Q9CWB9|uniprotkb:Q9D2W2 intact:EBI-6654585|ensembl:ENSMUSP00000015484 psi-mi:cy24a_mouse(display_long)|uniprotkb:Cyba(gene name)|psi-mi:Cyba(display_short)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:p22-phox(gene name synonym) psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16102796|imex:IM-22691-4|dip:DIP-196551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|ensembl:ENSMUSG00000006519(gene)|ensembl:ENSMUST00000017604(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001288213.1|refseq:NP_031832.2|dip:DIP-60456N ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/08 2017/08/10 rogid:Sqox5aGM2G1TXSpKwI1o/tK103A10090 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rigid:VaG2Fiq07fHNV0Bpc63ojU2n9vU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q61462 uniprotkb:Q61093 intact:EBI-15795776|ensembl:ENSMUSP00000017604|uniprotkb:Q3U820|uniprotkb:Q9CWB9|uniprotkb:Q9D2W2 intact:EBI-6654585|ensembl:ENSMUSP00000015484 psi-mi:cy24a_mouse(display_long)|uniprotkb:Cyba(gene name)|psi-mi:Cyba(display_short)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:p22-phox(gene name synonym) psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16102813|imex:IM-22691-5|dip:DIP-196551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|ensembl:ENSMUSG00000006519(gene)|ensembl:ENSMUST00000017604(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_001288213.1|refseq:NP_031832.2|dip:DIP-60456N ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/08 2017/08/10 rogid:Sqox5aGM2G1TXSpKwI1o/tK103A10090 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rigid:VaG2Fiq07fHNV0Bpc63ojU2n9vU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8BMT4 uniprotkb:Q61093 intact:EBI-16102695|ensembl:ENSMUSP00000097571|ensembl:ENSMUSP00000116388|ensembl:ENSMUSP00000119349|uniprotkb:Q3TIA8|uniprotkb:Q8BTT4|uniprotkb:Q8BUI7|uniprotkb:Q8BY16|uniprotkb:Q8R063 intact:EBI-6654585|ensembl:ENSMUSP00000015484 psi-mi:lrc33_mouse(display_long)|uniprotkb:Negative regulator of reactive oxygen species(gene name synonym)|uniprotkb:Nrros(gene name)|psi-mi:Nrros(display_short)|uniprotkb:Lrrc33(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 33(gene name synonym) psi-mi:cy24b_mouse(display_long)|uniprotkb:Cybb(gene name)|psi-mi:Cybb(display_short)|uniprotkb:Cgd(gene name synonym)|uniprotkb:CGD91-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) subunit beta"(gene name synonym)|uniprotkb:Heme-binding membrane glycoprotein gp91phox(gene name synonym)|uniprotkb:Neutrophil cytochrome b 91 kDa polypeptide(gene name synonym)|uniprotkb:gp91-1(gene name synonym)|uniprotkb:gp91-phox(gene name synonym)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Noubade et al. (2014) pubmed:24739962|doi:10.1038/nature13152|imex:IM-22691 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16102830|imex:IM-22691-6|dip:DIP-196552E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000052384(gene)|ensembl:ENSMUST00000099991(transcript)|ensembl:ENSMUST00000126869(transcript)|ensembl:ENSMUST00000143682(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0014005"(microglia development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0036364"(transforming growth factor beta1 activation)|go:"GO:0050431"(transforming growth factor beta binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_001334110.1|refseq:NP_001334111.1|refseq:NP_666181.2|refseq:XP_006522137.1|refseq:XP_006522138.1|refseq:XP_006522139.1|refseq:XP_006522140.1|refseq:XP_017172451.1|dip:DIP-60840N ensembl:ENSMUSG00000015340(gene)|ensembl:ENSMUST00000015484(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007584"(response to nutrient)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0020037"(heme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0030425"(dendrite)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000778(Cytochrome b-245, heavy chain)|interpro:IPR013112(FAD-binding 8)|interpro:IPR013121(Ferric reductase, NAD binding)|interpro:IPR013130(Ferric reductase-like transmembrane component, N-terminal)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045730"(respiratory burst)|go:"GO:0045766"(positive regulation of angiogenesis)|refseq:XP_006527628.1|refseq:NP_031833.3|dip:DIP-60841N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") - 2017/08/08 2017/08/10 rogid:wKD0HBLc0vmoeUBsxhS/K7tMmlg10090 rogid:BHOhGoiuMmOMgV3w9wz1dpla7XU10090 rigid:006P++Ge6LWAAiGpBm8P2KmLrrA false flag tag:c-c - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)