#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15516	uniprotkb:Q2VPD4	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-9696862|uniprotkb:Q32MV7|uniprotkb:Q91XJ5|uniprotkb:Q91XJ6|ensembl:ENSMUSP00000079373|ensembl:ENSMUSP00000107266	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:bmal2_mouse(display_long)|uniprotkb:Arntl2(gene name)|psi-mi:Arntl2(display_short)|uniprotkb:Bmal2(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101799|imex:IM-22678-2|dip:DIP-196481E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	dip:DIP-60819N|refseq:NP_001276608.1|refseq:NP_001276609.1|refseq:NP_001276610.1|refseq:NP_758513.1|refseq:XP_006507116.1|ensembl:ENSMUSG00000040187(gene)|ensembl:ENSMUST00000080530(transcript)|ensembl:ENSMUST00000111639(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:sy8qVip2KyixzBAJ+HNuwlQ6rHA10090	rigid:fIOn0yMezPDLx51R+DKMqtDJmf8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:Q9R194	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101782|imex:IM-22678-1|dip:DIP-196488E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090	rigid:6uidpIHgMd0NcwQreExGRlDHGPY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101816|imex:IM-22678-3|dip:DIP-196483E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:mPutGFIGJ7OR+K7ot+rLFf6F2rQ	false	n-venus:c-c	c-venus:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9D103	uniprotkb:P97784	intact:EBI-16101837|ensembl:ENSMUSP00000026564|ensembl:ENSMUSP00000101655|ensembl:ENSMUSP00000101657|uniprotkb:Q8R2S7	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:ifm1_mouse(display_long)|uniprotkb:Ifitm1(gene name)|psi-mi:Ifitm1(display_short)|uniprotkb:Dispanin subfamily A member 2a(gene name synonym)|uniprotkb:Fragilis protein 2(gene name synonym)|uniprotkb:Mouse ifitm-like protein 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101874|imex:IM-22678-4|dip:DIP-196500E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025491(gene)|ensembl:ENSMUST00000026564(transcript)|ensembl:ENSMUST00000106040(transcript)|ensembl:ENSMUST00000106042(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001756"(somitogenesis)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007593(Interferon-induced transmembrane protein)|reactome:R-MMU-198933|refseq:NP_001106186.1|refseq:NP_081096.3|refseq:XP_006536301.1|dip:DIP-60824N	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:/ybJxzYmN7FbtHRG1HJsT8Fkqe810090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:PQId2lVViB4LB6Cjy6Ign+UdIOE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:O54943	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266779|uniprotkb:O54954	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101891|imex:IM-22678-5|dip:DIP-102835E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:wSaRZ4zlIZE1Wk20+gTtTPGf9Sc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q91WT9	uniprotkb:P97784	intact:EBI-8376311|intact:MINT-4121506|intact:MINT-1869837|uniprotkb:Q91WU3|ensembl:ENSMUSP00000066878|ensembl:ENSMUSP00000158269	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:cbs_mouse(display_long)|uniprotkb:Cbs(gene name)|psi-mi:Cbs(display_short)|uniprotkb:Serine sulfhydrase(gene name synonym)|uniprotkb:Beta-thionase(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101908|imex:IM-22678-6|dip:DIP-196499E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258282.1|refseq:NP_835742.1|refseq:NP_659104.1|refseq:XP_006523612.1|refseq:XP_006523613.1|refseq:XP_006523614.1|dip:DIP-60823N|ensembl:ENSMUSG00000024039(gene)|ensembl:ENSMUST00000067801(transcript)|ensembl:ENSMUST00000236853(transcript)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0004122"(cystathionine beta-synthase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006535"(cysteine biosynthetic process from serine)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0019343"(cysteine biosynthetic process via cystathionine)|go:"GO:0019344"(cysteine biosynthetic process)|go:"GO:0019346"(transsulfuration)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050421"("nitrite reductase (NO-forming) activity")|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0051593"(response to folic acid)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0070025"(carbon monoxide binding)|go:"GO:0070026"(nitric oxide binding)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072341"(modified amino acid binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001216(Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site)|interpro:IPR001926(Pyridoxal phosphate-dependent enzyme, beta subunit)|interpro:IPR005857(Cystathionine beta-synthase)|interpro:IPR036052|mint:Q91WT9|reactome:R-MMU-1614603|go:"GO:0019825"(oxygen binding)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:8MpZ6/6To4M47ztgEE6QQ41SYys10090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:FkhIDe02JMhxqoPtgfmfS6/kJVk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99743	uniprotkb:Q2VPD4	intact:EBI-3932727|uniprotkb:Q86V96|uniprotkb:Q4ZFV9|uniprotkb:Q99629|uniprotkb:Q53SQ3|ensembl:ENSP00000338283	intact:EBI-9696862|uniprotkb:Q32MV7|uniprotkb:Q91XJ5|uniprotkb:Q91XJ6|ensembl:ENSMUSP00000079373|ensembl:ENSMUSP00000107266	psi-mi:npas2_human(display_long)|uniprotkb:NPAS2(gene name)|psi-mi:NPAS2(display_short)|uniprotkb:BHLHE9(gene name synonym)|uniprotkb:MOP4(gene name synonym)|uniprotkb:PASD4(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP4(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 9(gene name synonym)|uniprotkb:Member of PAS protein 4(gene name synonym)|uniprotkb:PAS domain-containing protein 4(gene name synonym)	psi-mi:bmal2_mouse(display_long)|uniprotkb:Arntl2(gene name)|psi-mi:Arntl2(display_short)|uniprotkb:Bmal2(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101925|imex:IM-22678-7|dip:DIP-196482E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170485(gene)|ensembl:ENST00000335681(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007417"(central nervous system development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042493"|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616|refseq:NP_002509.2|dip:DIP-60821N	dip:DIP-60819N|refseq:NP_001276608.1|refseq:NP_001276609.1|refseq:NP_001276610.1|refseq:NP_758513.1|refseq:XP_006507116.1|ensembl:ENSMUSG00000040187(gene)|ensembl:ENSMUST00000080530(transcript)|ensembl:ENSMUST00000111639(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:XeKPOy2H9eb+ZoZvP64cuSIxZUg9606	rogid:sy8qVip2KyixzBAJ+HNuwlQ6rHA10090	rigid:8+x3KKVoGIs7+JNwNmeRuuxZEes	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:O54943	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-1266779|uniprotkb:O54954	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101942|imex:IM-22678-8|dip:DIP-196496E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:M/sGO974aNdXUey0EfiO1SSZ6lQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101980|imex:IM-22678-10|dip:DIP-196483E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:mPutGFIGJ7OR+K7ot+rLFf6F2rQ	false	-	sufficient binding region:78-626	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08785	uniprotkb:Q9WTL8	intact:EBI-79859|ensembl:ENSMUSP00000074656|ensembl:ENSMUSP00000143939	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:clock_mouse(display_long)|uniprotkb:Clock(gene name)|psi-mi:Clock(display_short)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101959|imex:IM-22678-9|dip:DIP-74555E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000029238(gene)|ensembl:ENSMUST00000075159(transcript)|ensembl:ENSMUST00000202651(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O08785|rcsb pdb:4F3L|rcsb pdb:5VJI|rcsb pdb:5VJX|refseq:NP_031741.1|dip:DIP-30958N|refseq:NP_001276755.1|refseq:XP_017176137.1|refseq:XP_017176139.1	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:C2KpIAqSKH1V/v/6hnYPYF/FfPY10090	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:rR6pjRMS7ztqZs2acls+5QZ2epA	false	n-venus:c-c	c-venus:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WTL8	uniprotkb:Q9R194	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16101999|imex:IM-22678-11|dip:DIP-196489E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090	rigid:t/KZmg6Gl4PHu/EPGYx0TkxYXNg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102033|imex:IM-22678-13|dip:DIP-196483E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:mPutGFIGJ7OR+K7ot+rLFf6F2rQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:O54943	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1266779|uniprotkb:O54954	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102016|imex:IM-22678-12|dip:DIP-196497E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:QfDYUa9cyf1BNqqrfYa1wg7mIIo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:Q8N365	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102050|imex:IM-22678-14|dip:DIP-196504E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rigid:MlxI2G2JTAP9M+gZpodiLtjCwQg	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9R194	uniprotkb:O54943	intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102071|imex:IM-22678-15|dip:DIP-188164E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:MrCq33ylc8KQ64VYwv538eatPg8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20393	uniprotkb:O54943	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	intact:EBI-1266779|uniprotkb:O54954	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102088|imex:IM-22678-16|dip:DIP-196502E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:14z9qJGO143S27PrdRsW0JNfdH0	false	flag tag:c-c	venus fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O54943	uniprotkb:P97784	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102109|imex:IM-22678-17|dip:DIP-187989E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O35973	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102126|imex:IM-22678-18|dip:DIP-196490E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rigid:6mor/DlpyhtN4XSCBgpkskCYfPc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:O15516	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102160|imex:IM-22678-20|dip:DIP-196487E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rigid:OunB5OQMs0A74+LlvUJCqV9+x9c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15516	uniprotkb:Q9WTL8	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102143|imex:IM-22678-19|dip:DIP-196484E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:4DYtgTI9Lo9D85i0Grkvc4wzqxA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70361	uniprotkb:Q8N365	intact:EBI-9695895|uniprotkb:A2A894|ensembl:ENSMUSP00000099493	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	psi-mi:per3_mouse(display_long)|uniprotkb:Per3(gene name)|psi-mi:Per3(display_short)|uniprotkb:Circadian clock protein PERIOD 3(gene name synonym)	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102177|imex:IM-22678-21|dip:DIP-196505E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60820N|refseq:NP_035197.2|ensembl:ENSMUSG00000028957(gene)|ensembl:ENSMUST00000103204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0050821"(protein stabilization)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR015524(Period circadian protein 3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:4DJ3	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:dQZ1xlPUbVLTNBbhVmhHdFTdZmU10090	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rigid:AtiOtyGAreHYwpJq4gsrypbSrts	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O54943	uniprotkb:Q8N365	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102198|imex:IM-22678-22|dip:DIP-196501E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rigid:7n0C09PQimREa3lwcQD/Waure5U	false	venus fluorescent protein tag:c-c	s tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O54943	uniprotkb:P20393	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102198|imex:IM-22678-22|dip:DIP-196501E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	rigid:7n0C09PQimREa3lwcQD/Waure5U	false	venus fluorescent protein tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O70361	uniprotkb:P97784	intact:EBI-9695895|uniprotkb:A2A894|ensembl:ENSMUSP00000099493	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:per3_mouse(display_long)|uniprotkb:Per3(gene name)|psi-mi:Per3(display_short)|uniprotkb:Circadian clock protein PERIOD 3(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102222|imex:IM-22678-23|dip:DIP-196491E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60820N|refseq:NP_035197.2|ensembl:ENSMUSG00000028957(gene)|ensembl:ENSMUST00000103204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0050821"(protein stabilization)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR015524(Period circadian protein 3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:4DJ3	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:dQZ1xlPUbVLTNBbhVmhHdFTdZmU10090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:EcieBwd5yiMO918dQIV+Z2V1WT4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O54943	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102239|imex:IM-22678-24|dip:DIP-187989E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:yUS3q/I05baQNxfoF5ZNTBL2PKs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99743	uniprotkb:Q2VPD4	intact:EBI-3932727|uniprotkb:Q86V96|uniprotkb:Q4ZFV9|uniprotkb:Q99629|uniprotkb:Q53SQ3|ensembl:ENSP00000338283	intact:EBI-9696862|uniprotkb:Q32MV7|uniprotkb:Q91XJ5|uniprotkb:Q91XJ6|ensembl:ENSMUSP00000079373|ensembl:ENSMUSP00000107266	psi-mi:npas2_human(display_long)|uniprotkb:NPAS2(gene name)|psi-mi:NPAS2(display_short)|uniprotkb:BHLHE9(gene name synonym)|uniprotkb:MOP4(gene name synonym)|uniprotkb:PASD4(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP4(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 9(gene name synonym)|uniprotkb:Member of PAS protein 4(gene name synonym)|uniprotkb:PAS domain-containing protein 4(gene name synonym)	psi-mi:bmal2_mouse(display_long)|uniprotkb:Arntl2(gene name)|psi-mi:Arntl2(display_short)|uniprotkb:Bmal2(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102256|imex:IM-22678-25|dip:DIP-196482E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170485(gene)|ensembl:ENST00000335681(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007417"(central nervous system development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042493"|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616|refseq:NP_002509.2|dip:DIP-60821N	dip:DIP-60819N|refseq:NP_001276608.1|refseq:NP_001276609.1|refseq:NP_001276610.1|refseq:NP_758513.1|refseq:XP_006507116.1|ensembl:ENSMUSG00000040187(gene)|ensembl:ENSMUST00000080530(transcript)|ensembl:ENSMUST00000111639(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:XeKPOy2H9eb+ZoZvP64cuSIxZUg9606	rogid:sy8qVip2KyixzBAJ+HNuwlQ6rHA10090	rigid:8+x3KKVoGIs7+JNwNmeRuuxZEes	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:O54943	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1266779|uniprotkb:O54954	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102273|imex:IM-22678-26|dip:DIP-196497E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:QfDYUa9cyf1BNqqrfYa1wg7mIIo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WTL8	uniprotkb:Q99743	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	intact:EBI-3932727|uniprotkb:Q86V96|uniprotkb:Q4ZFV9|uniprotkb:Q99629|uniprotkb:Q53SQ3|ensembl:ENSP00000338283	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:npas2_human(display_long)|uniprotkb:NPAS2(gene name)|psi-mi:NPAS2(display_short)|uniprotkb:BHLHE9(gene name synonym)|uniprotkb:MOP4(gene name synonym)|uniprotkb:PASD4(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP4(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 9(gene name synonym)|uniprotkb:Member of PAS protein 4(gene name synonym)|uniprotkb:PAS domain-containing protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102290|imex:IM-22678-27|dip:DIP-196485E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	ensembl:ENSG00000170485(gene)|ensembl:ENST00000335681(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007417"(central nervous system development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042493"|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616|refseq:NP_002509.2|dip:DIP-60821N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rogid:XeKPOy2H9eb+ZoZvP64cuSIxZUg9606	rigid:bADjcQDqFZs9BmudOkmXOactSJ0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00327	uniprotkb:Q92793	intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571	intact:EBI-81215|ensembl:ENSP00000262367|uniprotkb:O00147|uniprotkb:Q16376|uniprotkb:D3DUC9|uniprotkb:Q4LE28	psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym)	psi-mi:cbp_human(display_long)|uniprotkb:CREBBP(gene name)|psi-mi:CREBBP(display_short)|uniprotkb:CBP(gene name synonym)|uniprotkb:Histone lysine acetyltransferase CREBBP(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102307|imex:IM-22678-28|dip:DIP-196507E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616	ensembl:ENSG00000005339(gene)|ensembl:ENST00000262367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042592"(homeostatic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043426"(MRF binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|rcsb pdb:1WO7|rcsb pdb:1ZOQ|rcsb pdb:2D82|rcsb pdb:2KJE|rcsb pdb:2KWF|rcsb pdb:2L84|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q92793|rcsb pdb:1JSP|rcsb pdb:1LIQ|rcsb pdb:1RDT|rcsb pdb:1WO3|rcsb pdb:1WO4|rcsb pdb:1WO5|rcsb pdb:1WO6|rcsb pdb:2L85|rcsb pdb:2LXT|rcsb pdb:2LXS|rcsb pdb:3DWY|rcsb pdb:2N1A|rcsb pdb:3P1C|rcsb pdb:3P1D|refseq:NP_001073315.1|refseq:NP_004371.2|rcsb pdb:3P1E|rcsb pdb:3P1F|rcsb pdb:2RNY|rcsb pdb:6AY3|rcsb pdb:6AY5|rcsb pdb:6DMK|rcsb pdb:6ES5|rcsb pdb:6ES6|rcsb pdb:6ES7|rcsb pdb:6SQM|rcsb pdb:6FQO|rcsb pdb:6SXX|rcsb pdb:6YIJ|rcsb pdb:6YIK|rcsb pdb:6YIL|rcsb pdb:6YIM|rcsb pdb:6FQT|rcsb pdb:7CO1|rcsb pdb:7JFL|rcsb pdb:7JFM|reactome:R-HSA-1234158|rcsb pdb:6FQU|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1912408|rcsb pdb:6FR0|rcsb pdb:6FRF|rcsb pdb:6M64|rcsb pdb:6QST|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|rcsb pdb:6SQE|rcsb pdb:6SQF|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-6803204|reactome:R-HSA-8866907|reactome:R-HSA-8939246|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|rcsb pdb:3SVH|rcsb pdb:4A9K|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4NR4|rcsb pdb:4NR5|rcsb pdb:4NR6|rcsb pdb:4NR7|rcsb pdb:4NYV|rcsb pdb:4NYW|rcsb pdb:4NYX|rcsb pdb:4OUF|rcsb pdb:4TQN|rcsb pdb:4TS8|rcsb pdb:4WHU|rcsb pdb:4YK0|rcsb pdb:5CGP|rcsb pdb:5DBM|rcsb pdb:5EIC|rcsb pdb:5ENG|rcsb pdb:5EP7|rcsb pdb:5GH9|rcsb pdb:5H85|rcsb pdb:5I83|rcsb pdb:5I86|rcsb pdb:5I89|rcsb pdb:5I8B|rcsb pdb:5I8G|rcsb pdb:5J0D|rcsb pdb:5JEM|rcsb pdb:5KTU|rcsb pdb:5KTW|rcsb pdb:5KTX|rcsb pdb:5LPJ|rcsb pdb:5LPL|rcsb pdb:5MME|rcsb pdb:5MMG|rcsb pdb:5MPK|rcsb pdb:5MPN|rcsb pdb:5MPZ|rcsb pdb:5MQE|rcsb pdb:5MQG|rcsb pdb:5MQK|rcsb pdb:5NLK|rcsb pdb:5NRW|rcsb pdb:5NU3|rcsb pdb:5OWK|rcsb pdb:5SVH|rcsb pdb:5TB6|rcsb pdb:5W0E|rcsb pdb:5W0F|rcsb pdb:5W0L|rcsb pdb:5W0Q|rcsb pdb:5XXH|rcsb pdb:6ALB|rcsb pdb:6ALC|rcsb pdb:6AXQ|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-9617629|dip:DIP-952N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606	rogid:WWX7TFIpcDwoR5f5Sm1eQ6nma1E9606	rigid:qhtPr4o1xDA2oSCJI0SpYGSrG2Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15516	uniprotkb:Q9WTL8	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102324|imex:IM-22678-29|dip:DIP-196484E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:4DYtgTI9Lo9D85i0Grkvc4wzqxA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WTL8	uniprotkb:P97784	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102341|imex:IM-22678-30|dip:DIP-88915E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:OzB+5bQEj3eCCVPvV4j083Kdu3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99743	uniprotkb:P97784	intact:EBI-3932727|uniprotkb:Q86V96|uniprotkb:Q4ZFV9|uniprotkb:Q99629|uniprotkb:Q53SQ3|ensembl:ENSP00000338283	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:npas2_human(display_long)|uniprotkb:NPAS2(gene name)|psi-mi:NPAS2(display_short)|uniprotkb:BHLHE9(gene name synonym)|uniprotkb:MOP4(gene name synonym)|uniprotkb:PASD4(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP4(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 9(gene name synonym)|uniprotkb:Member of PAS protein 4(gene name synonym)|uniprotkb:PAS domain-containing protein 4(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102358|imex:IM-22678-31|dip:DIP-196493E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000170485(gene)|ensembl:ENST00000335681(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007417"(central nervous system development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042493"|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616|refseq:NP_002509.2|dip:DIP-60821N	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:XeKPOy2H9eb+ZoZvP64cuSIxZUg9606	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:JfUjVKjx/Ziyhf/EoW1JSq1ESOw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:O15516	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102375|imex:IM-22678-32|dip:DIP-196503E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rigid:Gu4pUHycopTPOqJzvlWHl9abDjY	false	s tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102375|imex:IM-22678-32|dip:DIP-196503E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:Gu4pUHycopTPOqJzvlWHl9abDjY	false	s tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15516	uniprotkb:Q2VPD4	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-9696862|uniprotkb:Q32MV7|uniprotkb:Q91XJ5|uniprotkb:Q91XJ6|ensembl:ENSMUSP00000079373|ensembl:ENSMUSP00000107266	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:bmal2_mouse(display_long)|uniprotkb:Arntl2(gene name)|psi-mi:Arntl2(display_short)|uniprotkb:Bmal2(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102399|imex:IM-22678-33|dip:DIP-196481E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	dip:DIP-60819N|refseq:NP_001276608.1|refseq:NP_001276609.1|refseq:NP_001276610.1|refseq:NP_758513.1|refseq:XP_006507116.1|ensembl:ENSMUSG00000040187(gene)|ensembl:ENSMUST00000080530(transcript)|ensembl:ENSMUST00000111639(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007623"(circadian rhythm)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:sy8qVip2KyixzBAJ+HNuwlQ6rHA10090	rigid:fIOn0yMezPDLx51R+DKMqtDJmf8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15516	uniprotkb:P97784	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-1266607|ensembl:ENSMUSP00000020227	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102416|imex:IM-22678-34|dip:DIP-196492E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rigid:e3Dk/g+pCl0h67eeIlMoj5E8C68	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:O35973	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102433|imex:IM-22678-35|dip:DIP-196498E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rigid:mt+rVZOUPOdX8XRl/WFCa5OaDPo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15516	uniprotkb:O15516	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102450|imex:IM-22678-36|dip:DIP-196486E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rigid:WjhDqtivofRIOzUuotmmVG9Fe/Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102467|imex:IM-22678-37|dip:DIP-196483E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:mPutGFIGJ7OR+K7ot+rLFf6F2rQ	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35973	uniprotkb:O70361	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-9695895|uniprotkb:A2A894|ensembl:ENSMUSP00000099493	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:per3_mouse(display_long)|uniprotkb:Per3(gene name)|psi-mi:Per3(display_short)|uniprotkb:Circadian clock protein PERIOD 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102488|imex:IM-22678-38|dip:DIP-196494E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	dip:DIP-60820N|refseq:NP_035197.2|ensembl:ENSMUSG00000028957(gene)|ensembl:ENSMUST00000103204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0050821"(protein stabilization)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR015524(Period circadian protein 3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:4DJ3	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:dQZ1xlPUbVLTNBbhVmhHdFTdZmU10090	rigid:hrVwrkn+tjm4/2w/jL+VMabBmBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:O54943	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-1266779|uniprotkb:O54954	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102505|imex:IM-22678-39|dip:DIP-196496E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:M/sGO974aNdXUey0EfiO1SSZ6lQ	false	flag tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N365	uniprotkb:O54943	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-1266779|uniprotkb:O54954	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102526|imex:IM-22678-40|dip:DIP-196496E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:M/sGO974aNdXUey0EfiO1SSZ6lQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97784	uniprotkb:O35973	intact:EBI-1266607|ensembl:ENSMUSP00000020227	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	psi-mi:cry1_mouse(display_long)|uniprotkb:Cry1(gene name)|psi-mi:Cry1(display_short)	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102543|imex:IM-22678-41|dip:DIP-196490E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031797.1|dip:DIP-38515N|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033762"(response to glucagon)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|go:"GO:0071949"(FAD binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:P97784|rcsb pdb:4CT0|rcsb pdb:4K0R|rcsb pdb:5T5X|rcsb pdb:6KX4|rcsb pdb:6KX5|rcsb pdb:6KX6|rcsb pdb:6KX7|rcsb pdb:6LUE|rcsb pdb:6OF7|rcsb pdb:7D0M|rcsb pdb:7D19|rcsb pdb:7D1C|rcsb pdb:7DLI|ensembl:ENSMUSG00000020038(gene)|ensembl:ENSMUST00000020227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032868"(response to insulin)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:V0etJNAuSn2k4pmE9bZ0UWpv8SM10090	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rigid:6mor/DlpyhtN4XSCBgpkskCYfPc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P45481	uniprotkb:Q9WTL8	intact:EBI-296306|uniprotkb:E9QPH4	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:cbp_mouse(display_long)|uniprotkb:Crebbp(gene name)|psi-mi:Crebbp(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Protein-lysine acetyltransferase CREBBP(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102560|imex:IM-22678-42|dip:DIP-196506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000940"(outer kinetochore)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043426"(MRF binding)|rcsb pdb:1KBH|rcsb pdb:1KDX|rcsb pdb:1JJS|rcsb pdb:1L8C|rcsb pdb:1R8U|rcsb pdb:1SB0|rcsb pdb:1TOT|rcsb pdb:1U2N|rcsb pdb:2AGH|rcsb pdb:2C52|rcsb pdb:2KA4|rcsb pdb:2KA6|rcsb pdb:2KKJ|rcsb pdb:2L14|rcsb pdb:2LQH|rcsb pdb:2LQI|rcsb pdb:2LWW|rcsb pdb:4I9O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5U4K|rcsb pdb:5U7G|rcsb pdb:5W0I|rcsb pdb:6DMX|rcsb pdb:6DNQ|reactome:R-MMU-1234158|reactome:R-MMU-201722|reactome:R-MMU-2122947|reactome:R-MMU-3134973|reactome:R-MMU-3371568|reactome:R-MMU-350054|reactome:R-MMU-400206|reactome:R-MMU-5621575|reactome:R-MMU-8866907|reactome:R-MMU-8939246|reactome:R-MMU-8941856|reactome:R-MMU-9018519|reactome:R-MMU-918233|reactome:R-MMU-933541|reactome:R-MMU-9617629|reactome:R-MMU-9707564|go:"GO:0046332"(SMAD binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990258"(histone glutamine methylation)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|rcsb pdb:1F81|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|mint:P45481|dip:DIP-5974N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:sBMFm6ZE5MtCDEN3UiSiwTbvSqA10090	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:zVR+ZlhpwvCiMMfKu7WLquYNkhs	false	n-venus:c-c	c-venus:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:O15516	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-1794265|uniprotkb:A0AV01|uniprotkb:O14516|uniprotkb:Q9UIT8|uniprotkb:A2I2N9|ensembl:ENSP00000308741|ensembl:ENSP00000370723|ensembl:ENSP00000426983	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:clock_human(display_long)|uniprotkb:CLOCK(gene name)|psi-mi:CLOCK(display_short)|uniprotkb:KIAA0334(gene name synonym)|uniprotkb:BHLHE8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102581|imex:IM-22678-43|dip:DIP-196487E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	refseq:XP_011532711.1|refseq:XP_011532712.1|refseq:XP_011532713.1|refseq:NP_004889.1|refseq:XP_016864343.1|refseq:NP_001254772.1|refseq:XP_005265844.1|dip:DIP-46009N|ensembl:ENSG00000134852(gene)|ensembl:ENST00000309964(transcript)|ensembl:ENST00000381322(transcript)|ensembl:ENST00000513440(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006473"(protein acetylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009648"(photoperiodism)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051775"(response to redox state)|go:"GO:0070888"(E-box binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|mint:O15516|rcsb pdb:4H10|rcsb pdb:6QPJ|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-3214847|reactome:R-HSA-400253|reactome:R-HSA-9707616	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:bnvElV5HCTAAT1rItDfxE6zoY/M9606	rigid:OunB5OQMs0A74+LlvUJCqV9+x9c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35973	uniprotkb:Q9R194	intact:EBI-1266764|uniprotkb:B1ASX0|ensembl:ENSMUSP00000021271|ensembl:ENSMUSP00000132635	intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909	psi-mi:per1_mouse(display_long)|uniprotkb:Per1(gene name)|psi-mi:Per1(display_short)|uniprotkb:Per(gene name synonym)|uniprotkb:Rigui(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)	psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102598|imex:IM-22678-44|dip:DIP-196488E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152839.1|refseq:NP_035195.2|refseq:XP_006532543.1|dip:DIP-38519N|ensembl:ENSMUSG00000020893(gene)|ensembl:ENSMUST00000021271(transcript)|ensembl:ENSMUST00000166748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|mint:O35973|rcsb pdb:4DJ2	refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:r2joaV40f8H8SBm7c+fmZ9fPdC410090	rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090	rigid:6uidpIHgMd0NcwQreExGRlDHGPY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N365	uniprotkb:Q9WTL8	intact:EBI-10265133|uniprotkb:D3DV01|uniprotkb:Q96MG6|uniprotkb:Q8N795|uniprotkb:B2RD43|ensembl:ENSP00000290363|ensembl:ENSP00000358091	intact:EBI-644534|uniprotkb:O88295|uniprotkb:Q921S4|uniprotkb:Q9R0U2|uniprotkb:Q9WTL9	psi-mi:ciart_human(display_long)|uniprotkb:CIART(gene name)|psi-mi:CIART(display_short)|uniprotkb:C1orf51(gene name synonym)|uniprotkb:ChIP-derived repressor of network oscillator(gene name synonym)|uniprotkb:Computationally highlighted repressor of the network oscillator(gene name synonym)	psi-mi:bmal1_mouse(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102615|imex:IM-22678-45|dip:DIP-196483E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287767.1|refseq:NP_001287769.1|refseq:NP_001287770.1|refseq:NP_653298.1|ensembl:ENSG00000159208(gene)|ensembl:ENST00000290363(transcript)|ensembl:ENST00000369095(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0016605"(PML body)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070888"(E-box binding)|interpro:IPR031373|dip:DIP-60822N	refseq:NP_001229977.1|refseq:NP_031515.1|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060137"(maternal process involved in parturition)|go:"GO:0070888"(E-box binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4F3L|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|refseq:XP_006507314.1|refseq:XP_017177438.1|refseq:XP_017177439.1|dip:DIP-43977N|mint:Q9WTL8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:fnzIT9sN76uWA2UbxRmpNn1CVyk9606	rogid:dZsboMuYuWHsdO5D4p4DsYkZ9wY10090	rigid:mPutGFIGJ7OR+K7ot+rLFf6F2rQ	false	s tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9R194	uniprotkb:O54943	intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909	intact:EBI-1266779|uniprotkb:O54954	psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym)	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102636|imex:IM-22678-46|dip:DIP-188164E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rigid:MrCq33ylc8KQ64VYwv538eatPg8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54943	uniprotkb:O70361	intact:EBI-1266779|uniprotkb:O54954	intact:EBI-9695895|uniprotkb:A2A894|ensembl:ENSMUSP00000099493	psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym)	psi-mi:per3_mouse(display_long)|uniprotkb:Per3(gene name)|psi-mi:Per3(display_short)|uniprotkb:Circadian clock protein PERIOD 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Anafi et al. (2014)	pubmed:24737000|doi:10.1371/journal.pbio.1001840|imex:IM-22678	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16102653|imex:IM-22678-47|dip:DIP-196495E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H	dip:DIP-60820N|refseq:NP_035197.2|ensembl:ENSMUSG00000028957(gene)|ensembl:ENSMUST00000103204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007623"(circadian rhythm)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0050821"(protein stabilization)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR015524(Period circadian protein 3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:4DJ3	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090	rogid:dQZ1xlPUbVLTNBbhVmhHdFTdZmU10090	rigid:FsDu3Kgs6tNJtTcpPhPQswcx/Dg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)