#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13190-1 uniprotkb:O75396 intact:EBI-16099777|ensembl:ENSP00000294179 intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0 psi-mi:q13190-1(display_long)|uniprotkb:STX5(gene name)|psi-mi:STX5(display_short)|uniprotkb:STX5A(gene name synonym) psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:"MI:0018"(two hybrid) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099785|imex:IM-22706-1|dip:DIP-196587E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162236(gene)|ensembl:ENST00000294179(transcript)|intact:EBI-714206(isoform-parent) ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2021/11/30 rogid:cR4cS695ZWQQ5Bkim9HqmCE0hCE9606 rogid:DRKtD169T9eYZ2kFufLapidvcKs9606 rigid:PYqDrJv2vV1lF9+aSoByRdOMw8k false sufficient binding region:130-331 sufficient binding region:1-196 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O08547 uniprotkb:O35526 intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099808|imex:IM-22706-2|dip:DIP-196589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434 refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/07 2017/08/10 rogid:DRKtD169T9eYZ2kFufLapidvcKs10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:rEppIZws+R85l+ahyNyJasuNluM false green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q16623-1 uniprotkb:O75396 intact:EBI-16099865|ensembl:ENSP00000222812 intact:EBI-1058865|ensembl:ENSP00000463393|uniprotkb:A8K1G0 psi-mi:q16623-1(display_long)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:STX1A(gene name)|psi-mi:STX1A(display_short)|uniprotkb:STX1(gene name synonym) psi-mi:sc22b_human(display_long)|uniprotkb:SEC22B(gene name)|psi-mi:SEC22B(display_short)|uniprotkb:SEC22L1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:"MI:0018"(two hybrid) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099873|imex:IM-22706-5|dip:DIP-196588E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106089(gene)|ensembl:ENST00000222812(transcript)|intact:EBI-712466(isoform-parent) ensembl:ENSG00000265808(gene)|ensembl:ENST00000578049(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O75396|rcsb pdb:2NUP|rcsb pdb:2NUT|rcsb pdb:3EGD|rcsb pdb:3EGX|refseq:NP_004883.3|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6811434|reactome:R-HSA-1236974|dip:DIP-50458N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2021/11/30 rogid:2OJ1A7RC63MTlOJmpv/jPx4IvGE9606 rogid:DRKtD169T9eYZ2kFufLapidvcKs9606 rigid:T8QGWH9FWUDrfb9OMqe0OqxUVaU false sufficient binding region:148-264 sufficient binding region:1-196 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P60879 uniprotkb:P63044 intact:EBI-445270|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:A2AIC2|uniprotkb:A2AIC3|ensembl:ENSMUSP00000028727 intact:EBI-521920|uniprotkb:Q64357|ensembl:ENSMUSP00000021273 psi-mi:snp25_mouse(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym) psi-mi:vamp2_mouse(display_long)|uniprotkb:Vamp2(gene name)|psi-mi:Vamp2(display_short)|uniprotkb:Syb2(gene name synonym)|uniprotkb:Synaptobrevin-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099848|imex:IM-22706-4|dip:DIP-185213E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277985.1|refseq:NP_035558.1|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60879|rcsb pdb:2BU0|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|go:"GO:0045121"(membrane raft)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|reactome:R-MMU-6798695|reactome:R-MMU-888590|reactome:R-MMU-449836|refseq:XP_017172247.1|refseq:XP_017172249.1|reactome:R-MMU-264642|ensembl:ENSMUST00000028727(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|ensembl:ENSMUSG00000027273(gene)|go:"GO:0007616"(long-term memory)|dip:DIP-29066N refseq:NP_033523.1|ensembl:ENSMUSG00000020894(gene)|ensembl:ENSMUST00000021273(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045202"(synapse)|go:"GO:0046879"(hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|dip:DIP-29065N|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63044|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-199992|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|reactome:R-MMU-9609523 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10090 rogid:7XvjYTyMU62KV/BKEItoUAtIL5010090 rigid:ht56q9IesbqEKMoKw4QJvtvj/Ro false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P32867 uniprotkb:P22214 intact:EBI-2206525|uniprotkb:D6W3D8|ensemblfungi:YPL232W intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:sso1_yeast(display_long)|uniprotkb:SSO1(gene name)|psi-mi:SSO1(display_short)|uniprotkb:P1405(orf name)|uniprotkb:YPL232W(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099829|imex:IM-22706-3|dip:DIP-196592E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-2494N|reactome:R-SCE-114516|refseq:NP_015092.1|sgd:S000006153|reactome:R-SCE-9609523|reactome:R-SCE-199992|ensemblfungi:YPL232W(gene)|ensemblfungi:YPL232W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030437"(ascospore formation)|go:"GO:0031201"(SNARE complex)|go:"GO:0031321"(ascospore-type prospore assembly)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|rcsb pdb:1FIO|rcsb pdb:3B5N refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N psi-mi:"MI:0465"(dip) crc64:6E4C6D35C3CD9D94 crc64:9FA3E34EAAFB9536 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:jGGWXFONgF8tb8qmlz8GnDfotuI559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:6qD5u21i0AYHpj23CivdRAUc1xA false - green fluorescent protein tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O09044 uniprotkb:P63044 intact:EBI-1812522|uniprotkb:O35620|ensembl:ENSMUSP00000028743|ensembl:ENSMUSP00000106339 intact:EBI-521920|uniprotkb:Q64357|ensembl:ENSMUSP00000021273 psi-mi:snp23_mouse(display_long)|uniprotkb:Snap23(gene name)|psi-mi:Snap23(display_short)|uniprotkb:Sndt(gene name synonym)|uniprotkb:Vesicle-membrane fusion protein SNAP-23(gene name synonym)|uniprotkb:Syndet(gene name synonym) psi-mi:vamp2_mouse(display_long)|uniprotkb:Vamp2(gene name)|psi-mi:Vamp2(display_short)|uniprotkb:Syb2(gene name synonym)|uniprotkb:Synaptobrevin-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099894|imex:IM-22706-6|dip:DIP-196590E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006499120.1|refseq:NP_001171263.1|refseq:NP_001171264.1|refseq:NP_033248.1|dip:DIP-41401N|ensembl:ENSMUSG00000027287(gene)|ensembl:ENSMUST00000028743(transcript)|ensembl:ENSMUST00000110711(transcript)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043005"(neuron projection)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013423|reactome:R-MMU-9035034 refseq:NP_033523.1|ensembl:ENSMUSG00000020894(gene)|ensembl:ENSMUST00000021273(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045202"(synapse)|go:"GO:0046879"(hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|dip:DIP-29065N|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63044|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-199992|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|reactome:R-MMU-9609523 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:x9MAn2ftkIOcj+VDRn8omysTxns10090 rogid:7XvjYTyMU62KV/BKEItoUAtIL5010090 rigid:KvjGQ/YI6DmH151e3H/dHUZ47nQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O09044 uniprotkb:O35526 intact:EBI-1812522|uniprotkb:O35620|ensembl:ENSMUSP00000028743|ensembl:ENSMUSP00000106339 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:snp23_mouse(display_long)|uniprotkb:Snap23(gene name)|psi-mi:Snap23(display_short)|uniprotkb:Sndt(gene name synonym)|uniprotkb:Vesicle-membrane fusion protein SNAP-23(gene name synonym)|uniprotkb:Syndet(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099894|imex:IM-22706-6|dip:DIP-196590E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006499120.1|refseq:NP_001171263.1|refseq:NP_001171264.1|refseq:NP_033248.1|dip:DIP-41401N|ensembl:ENSMUSG00000027287(gene)|ensembl:ENSMUST00000028743(transcript)|ensembl:ENSMUST00000110711(transcript)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043005"(neuron projection)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013423|reactome:R-MMU-9035034 refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:x9MAn2ftkIOcj+VDRn8omysTxns10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:KvjGQ/YI6DmH151e3H/dHUZ47nQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q12451 uniprotkb:P32867 intact:EBI-12621|uniprotkb:P89891|uniprotkb:D6VRX1|ensemblfungi:YDL019C intact:EBI-2206525|uniprotkb:D6W3D8|ensemblfungi:YPL232W psi-mi:osh2_yeast(display_long)|uniprotkb:D2845(orf name)|uniprotkb:YDL019C(locus name)|uniprotkb:OSH2(gene name)|psi-mi:OSH2(display_short) psi-mi:sso1_yeast(display_long)|uniprotkb:SSO1(gene name)|psi-mi:SSO1(display_short)|uniprotkb:P1405(orf name)|uniprotkb:YPL232W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099912|imex:IM-22706-7|dip:DIP-196593E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YDL019C(gene)|ensemblfungi:YDL019C_mRNA(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071944"(cell periphery)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR036770|interpro:IPR037239|reactome:R-SCE-192105|go:"GO:0120015"(sterol transfer activity)|refseq:NP_010265.1|sgd:S000002177|mint:Q12451|dip:DIP-6712N dip:DIP-2494N|reactome:R-SCE-114516|refseq:NP_015092.1|sgd:S000006153|reactome:R-SCE-9609523|reactome:R-SCE-199992|ensemblfungi:YPL232W(gene)|ensemblfungi:YPL232W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030437"(ascospore formation)|go:"GO:0031201"(SNARE complex)|go:"GO:0031321"(ascospore-type prospore assembly)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|rcsb pdb:1FIO|rcsb pdb:3B5N psi-mi:"MI:0465"(dip) crc64:D521957460E7F7C3 crc64:6E4C6D35C3CD9D94 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:75/WAoxCRsenLJMmbyowdFQ8srs559292 rogid:jGGWXFONgF8tb8qmlz8GnDfotuI559292 rigid:sxqqZYtH6wwYdn1vgmV9W52pBdM false green fluorescent protein tag:c-c - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q12451 uniprotkb:P22214 intact:EBI-12621|uniprotkb:P89891|uniprotkb:D6VRX1|ensemblfungi:YDL019C intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:osh2_yeast(display_long)|uniprotkb:D2845(orf name)|uniprotkb:YDL019C(locus name)|uniprotkb:OSH2(gene name)|psi-mi:OSH2(display_short) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099912|imex:IM-22706-7|dip:DIP-196593E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YDL019C(gene)|ensemblfungi:YDL019C_mRNA(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0008289"(lipid binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071944"(cell periphery)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR036770|interpro:IPR037239|reactome:R-SCE-192105|go:"GO:0120015"(sterol transfer activity)|refseq:NP_010265.1|sgd:S000002177|mint:Q12451|dip:DIP-6712N refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N psi-mi:"MI:0465"(dip) crc64:D521957460E7F7C3 crc64:9FA3E34EAAFB9536 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:75/WAoxCRsenLJMmbyowdFQ8srs559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:sxqqZYtH6wwYdn1vgmV9W52pBdM false green fluorescent protein tag:c-c - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O08547 uniprotkb:O35526 intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099932|imex:IM-22706-8|dip:DIP-196589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434 refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:DRKtD169T9eYZ2kFufLapidvcKs10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:rEppIZws+R85l+ahyNyJasuNluM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9ERB0 uniprotkb:P63044 intact:EBI-6556025|ensembl:ENSMUSP00000023449|uniprotkb:Q3UGN0|uniprotkb:Q9DBC5 intact:EBI-521920|uniprotkb:Q64357|ensembl:ENSMUSP00000021273 psi-mi:snp29_mouse(display_long)|uniprotkb:Snap29(gene name)|psi-mi:Snap29(display_short)|uniprotkb:Golgi SNARE of 32 kDa(gene name synonym)|uniprotkb:Soluble 29 kDa NSF attachment protein(gene name synonym)|uniprotkb:Vesicle-membrane fusion protein SNAP-29(gene name synonym) psi-mi:vamp2_mouse(display_long)|uniprotkb:Vamp2(gene name)|psi-mi:Vamp2(display_short)|uniprotkb:Syb2(gene name synonym)|uniprotkb:Synaptobrevin-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099949|imex:IM-22706-9|dip:DIP-196591E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-6811438|reactome:R-MMU-6798695|ensembl:ENSMUSG00000022765(gene)|ensembl:ENSMUST00000023449(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019905"(syntaxin binding)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_075837.3|dip:DIP-60853N refseq:NP_033523.1|ensembl:ENSMUSG00000020894(gene)|ensembl:ENSMUST00000021273(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045202"(synapse)|go:"GO:0046879"(hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|dip:DIP-29065N|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63044|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-199992|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|reactome:R-MMU-9609523 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:WOyDlpEmBYHGhZw4wyy8E9es4qk10090 rogid:7XvjYTyMU62KV/BKEItoUAtIL5010090 rigid:8d5ENidu61l9Pt4JFhDaB4q2A/U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9ERB0 uniprotkb:O35526 intact:EBI-6556025|ensembl:ENSMUSP00000023449|uniprotkb:Q3UGN0|uniprotkb:Q9DBC5 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:snp29_mouse(display_long)|uniprotkb:Snap29(gene name)|psi-mi:Snap29(display_short)|uniprotkb:Golgi SNARE of 32 kDa(gene name synonym)|uniprotkb:Soluble 29 kDa NSF attachment protein(gene name synonym)|uniprotkb:Vesicle-membrane fusion protein SNAP-29(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099949|imex:IM-22706-9|dip:DIP-196591E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-6811438|reactome:R-MMU-6798695|ensembl:ENSMUSG00000022765(gene)|ensembl:ENSMUST00000023449(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0015031"(protein transport)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0019905"(syntaxin binding)|go:"GO:0020018"(ciliary pocket membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR000727(Target SNARE coiled-coil region)|refseq:NP_075837.3|dip:DIP-60853N refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:WOyDlpEmBYHGhZw4wyy8E9es4qk10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:8d5ENidu61l9Pt4JFhDaB4q2A/U false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O08547 uniprotkb:O35526 intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16099967|imex:IM-22706-10|dip:DIP-196589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434 refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:DRKtD169T9eYZ2kFufLapidvcKs10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:rEppIZws+R85l+ahyNyJasuNluM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38713 uniprotkb:P32867 intact:EBI-12630|uniprotkb:D3DL23|ensemblfungi:YHR073W intact:EBI-2206525|uniprotkb:D6W3D8|ensemblfungi:YPL232W psi-mi:osh3_yeast(display_long)|uniprotkb:YHR073W(locus name)|uniprotkb:OSH3(gene name)|psi-mi:OSH3(display_short) psi-mi:sso1_yeast(display_long)|uniprotkb:SSO1(gene name)|psi-mi:SSO1(display_short)|uniprotkb:P1405(orf name)|uniprotkb:YPL232W(locus name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099984|imex:IM-22706-11|dip:DIP-196594E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YHR073W_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008289"(lipid binding)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|ensemblfungi:YHR073W(gene)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR036598|interpro:IPR037239|interpro:IPR041680|rcsb pdb:4IAP|rcsb pdb:4IC4|rcsb pdb:4INQ|reactome:R-SCE-192105|go:"GO:0035621"(ER to Golgi ceramide transport)|refseq:NP_011940.1|sgd:S000001115|mint:P38713|dip:DIP-2148N dip:DIP-2494N|reactome:R-SCE-114516|refseq:NP_015092.1|sgd:S000006153|reactome:R-SCE-9609523|reactome:R-SCE-199992|ensemblfungi:YPL232W(gene)|ensemblfungi:YPL232W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030437"(ascospore formation)|go:"GO:0031201"(SNARE complex)|go:"GO:0031321"(ascospore-type prospore assembly)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|rcsb pdb:1FIO|rcsb pdb:3B5N psi-mi:"MI:0465"(dip) crc64:B1AD1210EFFB9AFE crc64:6E4C6D35C3CD9D94 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:fhlpdXizvjnmxMYAM+Z/6AYPT4Y559292 rogid:jGGWXFONgF8tb8qmlz8GnDfotuI559292 rigid:sy7FtcDF2CpKgAb4Mb3rMjG7ono false green fluorescent protein tag:c-c - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P38713 uniprotkb:P22214 intact:EBI-12630|uniprotkb:D3DL23|ensemblfungi:YHR073W intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:osh3_yeast(display_long)|uniprotkb:YHR073W(locus name)|uniprotkb:OSH3(gene name)|psi-mi:OSH3(display_short) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16099984|imex:IM-22706-11|dip:DIP-196594E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YHR073W_mRNA(transcript)|go:"GO:0000742"(karyogamy involved in conjugation with cellular fusion)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0008289"(lipid binding)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0032934"(sterol binding)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|ensemblfungi:YHR073W(gene)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR036598|interpro:IPR037239|interpro:IPR041680|rcsb pdb:4IAP|rcsb pdb:4IC4|rcsb pdb:4INQ|reactome:R-SCE-192105|go:"GO:0035621"(ER to Golgi ceramide transport)|refseq:NP_011940.1|sgd:S000001115|mint:P38713|dip:DIP-2148N refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N psi-mi:"MI:0465"(dip) crc64:B1AD1210EFFB9AFE crc64:9FA3E34EAAFB9536 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:fhlpdXizvjnmxMYAM+Z/6AYPT4Y559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:sy7FtcDF2CpKgAb4Mb3rMjG7ono false green fluorescent protein tag:c-c - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P32867 uniprotkb:P22214 intact:EBI-2206525|uniprotkb:D6W3D8|ensemblfungi:YPL232W intact:EBI-16577|ensemblfungi:YLR268W|uniprotkb:D6VYR6 psi-mi:sso1_yeast(display_long)|uniprotkb:SSO1(gene name)|psi-mi:SSO1(display_short)|uniprotkb:P1405(orf name)|uniprotkb:YPL232W(locus name) psi-mi:sec22_yeast(display_long)|uniprotkb:SEC22(gene name)|psi-mi:SEC22(display_short)|uniprotkb:SLY2(gene name synonym)|uniprotkb:YLR268W(locus name)|uniprotkb:L8479.3(orf name)|uniprotkb:TSL26(gene name synonym)|uniprotkb:Suppressor of loss of YPT1 protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16100004|imex:IM-22706-12|dip:DIP-196592E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-2494N|reactome:R-SCE-114516|refseq:NP_015092.1|sgd:S000006153|reactome:R-SCE-9609523|reactome:R-SCE-199992|ensemblfungi:YPL232W(gene)|ensemblfungi:YPL232W_mRNA(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000329"(fungal-type vacuole membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005628"(prospore membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030437"(ascospore formation)|go:"GO:0031201"(SNARE complex)|go:"GO:0031321"(ascospore-type prospore assembly)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0071944"(cell periphery)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|rcsb pdb:1FIO|rcsb pdb:3B5N refseq:NP_013370.1|sgd:S000004258|ensemblfungi:YLR268W(gene)|ensemblfungi:YLR268W_mRNA(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0048279"(vesicle fusion with endoplasmic reticulum)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|go:"GO:0000139"(Golgi membrane)|reactome:R-SCE-204005|reactome:R-SCE-5694530|reactome:R-SCE-6811434|dip:DIP-2234N psi-mi:"MI:0465"(dip) crc64:6E4C6D35C3CD9D94 crc64:9FA3E34EAAFB9536 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:jGGWXFONgF8tb8qmlz8GnDfotuI559292 rogid:TjDU0GL+v84S+TwvRpJmF9CqhZ4559292 rigid:6qD5u21i0AYHpj23CivdRAUc1xA false green fluorescent protein tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P60879 uniprotkb:P63044 intact:EBI-445270|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:A2AIC2|uniprotkb:A2AIC3|ensembl:ENSMUSP00000028727 intact:EBI-521920|uniprotkb:Q64357|ensembl:ENSMUSP00000021273 psi-mi:snp25_mouse(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym) psi-mi:vamp2_mouse(display_long)|uniprotkb:Vamp2(gene name)|psi-mi:Vamp2(display_short)|uniprotkb:Syb2(gene name synonym)|uniprotkb:Synaptobrevin-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16100023|imex:IM-22706-13|dip:DIP-144083E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277985.1|refseq:NP_035558.1|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60879|rcsb pdb:2BU0|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|go:"GO:0045121"(membrane raft)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|reactome:R-MMU-6798695|reactome:R-MMU-888590|reactome:R-MMU-449836|refseq:XP_017172247.1|refseq:XP_017172249.1|reactome:R-MMU-264642|ensembl:ENSMUST00000028727(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|ensembl:ENSMUSG00000027273(gene)|go:"GO:0007616"(long-term memory)|dip:DIP-29066N refseq:NP_033523.1|ensembl:ENSMUSG00000020894(gene)|ensembl:ENSMUST00000021273(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009749"(response to glucose)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043229"(intracellular organelle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043308"(eosinophil degranulation)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045202"(synapse)|go:"GO:0046879"(hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1903421"(regulation of synaptic vesicle recycling)|interpro:IPR001388(Synaptobrevin)|dip:DIP-29065N|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR028717|interpro:IPR042855|mint:P63044|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-199992|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-888590|reactome:R-MMU-9609523 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10090 rogid:7XvjYTyMU62KV/BKEItoUAtIL5010090 rigid:vrRoN4jdUJyopojC5IBC5KVmwuM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P60879 uniprotkb:O35526 intact:EBI-445270|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|uniprotkb:A2AIC2|uniprotkb:A2AIC3|ensembl:ENSMUSP00000028727 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:snp25_mouse(display_long)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16100023|imex:IM-22706-13|dip:DIP-144083E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277985.1|refseq:NP_035558.1|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|mint:P60879|rcsb pdb:2BU0|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|go:"GO:0045121"(membrane raft)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|reactome:R-MMU-6798695|reactome:R-MMU-888590|reactome:R-MMU-449836|refseq:XP_017172247.1|refseq:XP_017172249.1|reactome:R-MMU-264642|ensembl:ENSMUST00000028727(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|ensembl:ENSMUSG00000027273(gene)|go:"GO:0007616"(long-term memory)|dip:DIP-29066N refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:vrRoN4jdUJyopojC5IBC5KVmwuM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O08547 uniprotkb:O35526 intact:EBI-8400083|intact:MINT-1865345|uniprotkb:Q91VU3|ensembl:ENSMUSP00000029476 intact:EBI-400878|ensembl:ENSMUSP00000005509 psi-mi:sc22b_mouse(display_long)|uniprotkb:Sec22b(gene name)|psi-mi:Sec22b(display_short)|uniprotkb:Sec22l1(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein homolog B(gene name synonym)|uniprotkb:SEC22 vesicle-trafficking protein-like 1(gene name synonym)|uniprotkb:ER-Golgi SNARE of 24 kDa(gene name synonym) psi-mi:stx1a_mouse(display_long)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Petkovic et al. (2014) pubmed:24705552|doi:10.1038/ncb2937|imex:IM-22706 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16100041|imex:IM-22706-14|dip:DIP-196589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035472.1|dip:DIP-60852N|ensembl:ENSMUSG00000027879(gene)|ensembl:ENSMUST00000029476(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042470"(melanosome)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:1902902"(negative regulation of autophagosome assembly)|interpro:IPR001388(Synaptobrevin)|interpro:IPR010908(Longin)|interpro:IPR011012(Longin-like)|interpro:IPR042855|interpro:IPR044565|mint:O08547|rcsb pdb:1IFQ|rcsb pdb:5VNE|rcsb pdb:5VNF|rcsb pdb:5VNG|rcsb pdb:5VNH|rcsb pdb:5VNI|rcsb pdb:5VNJ|rcsb pdb:5VNK|rcsb pdb:5VNL|rcsb pdb:5VNM|rcsb pdb:5VNN|rcsb pdb:5VNO|reactome:R-MMU-1236974|reactome:R-MMU-204005|reactome:R-MMU-5694530|reactome:R-MMU-6811434 refseq:NP_058081.2|dip:DIP-31950N|ensembl:ENSMUSG00000007207(gene)|ensembl:ENSMUST00000005509(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|reactome:R-MMU-9609523|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|mint:O35526|reactome:R-MMU-181429|reactome:R-MMU-181430|reactome:R-MMU-210500|reactome:R-MMU-212676|reactome:R-MMU-264642|reactome:R-MMU-449836|reactome:R-MMU-5682910|reactome:R-MMU-888590 psi-mi:"MI:0465"(dip) comment:mint|function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/07 2017/08/10 rogid:DRKtD169T9eYZ2kFufLapidvcKs10090 rogid:2lhU/XciJo2iiMvWJQAW7GaAOBs10090 rigid:rEppIZws+R85l+ahyNyJasuNluM false green fluorescent protein tag:n-n mcherry fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)