#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17861	uniprotkb:Q16665	intact:EBI-6942961|ensembl:ENSP00000216037|uniprotkb:Q969P1|intact:MINT-268152|uniprotkb:Q96BD7|uniprotkb:Q8WYK6	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:xbp1_human(display_long)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2014)	pubmed:24670641|doi:10.1038/nature13119|imex:IM-22367	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16097851|imex:IM-22367-1|dip:DIP-195915E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|rcsb pdb:6R5Q|rcsb pdb:6R6G|rcsb pdb:6R6P|rcsb pdb:6R7Q|reactome:R-HSA-381038|reactome:R-HSA-381070|reactome:R-HSA-381183|go:"GO:0071499"(cellular response to laminar fluid shear stress)|refseq:NP_001073007.1|refseq:NP_005071.2|dip:DIP-41692N	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	psi-mi:"MI:0465"(dip)	function:"Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rigid:iisewjsW/zFbeSo2Bq5oojvNX6E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861	uniprotkb:Q16665	intact:EBI-6942961|ensembl:ENSP00000216037|uniprotkb:Q969P1|intact:MINT-268152|uniprotkb:Q96BD7|uniprotkb:Q8WYK6	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:xbp1_human(display_long)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2014)	pubmed:24670641|doi:10.1038/nature13119|imex:IM-22367	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16097868|imex:IM-22367-2|dip:DIP-195915E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|rcsb pdb:6R5Q|rcsb pdb:6R6G|rcsb pdb:6R6P|rcsb pdb:6R7Q|reactome:R-HSA-381038|reactome:R-HSA-381070|reactome:R-HSA-381183|go:"GO:0071499"(cellular response to laminar fluid shear stress)|refseq:NP_001073007.1|refseq:NP_005071.2|dip:DIP-41692N	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	psi-mi:"MI:0465"(dip)	function:"Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rigid:iisewjsW/zFbeSo2Bq5oojvNX6E	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17861	uniprotkb:Q16665	intact:EBI-6942961|ensembl:ENSP00000216037|uniprotkb:Q969P1|intact:MINT-268152|uniprotkb:Q96BD7|uniprotkb:Q8WYK6	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:xbp1_human(display_long)|uniprotkb:XBP1(gene name)|psi-mi:XBP1(display_short)|uniprotkb:TREB5(gene name synonym)|uniprotkb:XBP2(gene name synonym)|uniprotkb:Tax-responsive element-binding protein 5(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chen et al. (2014)	pubmed:24670641|doi:10.1038/nature13119|imex:IM-22367	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16097887|imex:IM-22367-3|dip:DIP-195915E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100219(gene)|ensembl:ENST00000216037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903489"(positive regulation of lactation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|rcsb pdb:6R5Q|rcsb pdb:6R6G|rcsb pdb:6R6P|rcsb pdb:6R7Q|reactome:R-HSA-381038|reactome:R-HSA-381070|reactome:R-HSA-381183|go:"GO:0071499"(cellular response to laminar fluid shear stress)|refseq:NP_001073007.1|refseq:NP_005071.2|dip:DIP-41692N	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	psi-mi:"MI:0465"(dip)	function:"Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6QLd4DW85tnOCNFdL+hFZOPniEo9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rigid:iisewjsW/zFbeSo2Bq5oojvNX6E	false	sufficient binding region:1-133|glutathione s tranferase tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)