#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H1K1 uniprotkb:P38646 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103714|imex:IM-21965-1|dip:DIP-201543E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:8yUK3RkzVhed6gjqKGerxENyAac false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H1K1 uniprotkb:Q8IWL3 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103714|imex:IM-21965-1|dip:DIP-201543E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:8yUK3RkzVhed6gjqKGerxENyAac false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15103730|imex:IM-21965-2|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false ha tag:c-c|binding-associated region:29-280 flag tag:c-c|binding-associated region:29-235 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75446 uniprotkb:Q8IWL3 intact:EBI-632609|uniprotkb:D3DP38|ensembl:ENSP00000296504 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sap30_human(display_long)|uniprotkb:30 kDa Sin3-associated polypeptide(gene name synonym)|uniprotkb:Sin3 corepressor complex subunit SAP30(gene name synonym)|uniprotkb:SAP30(gene name)|psi-mi:SAP30(display_short)|uniprotkb:Sin3-associated polypeptide p30(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103755|imex:IM-21965-3|dip:DIP-201564E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003855.1|ensembl:ENSG00000164105(gene)|ensembl:ENST00000296504(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0052472"(modulation by host of symbiont transcription)|interpro:IPR024145|interpro:IPR025717|interpro:IPR025718|interpro:IPR038291|mint:O75446|rcsb pdb:2KDP|reactome:R-HSA-3214815|reactome:R-HSA-427413|reactome:R-HSA-9679191|dip:DIP-33328N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:w113AyekZAZr9VOJWcWEFIhqBYA9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:UYDiGEOpYxF1CLc96b0qB6Bi/XI false - sufficient binding region:29-235|sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y5T5 uniprotkb:Q8IWL3 intact:EBI-2513357|uniprotkb:B3KN13|uniprotkb:Q53GP7|uniprotkb:B4DY37|uniprotkb:Q53HA0|uniprotkb:B4DFV8|uniprotkb:A8MU43|uniprotkb:Q8NEL3|uniprotkb:Q9H3E6|uniprotkb:Q5VKN8|uniprotkb:D3DSD9|ensembl:ENSP00000334808|ensembl:ENSP00000382858 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ubp16_human(display_long)|uniprotkb:USP16(gene name)|psi-mi:USP16(display_short)|uniprotkb:Ubiquitin-specific-processing protease 16(gene name synonym)|uniprotkb:Deubiquitinating enzyme 16(gene name synonym)|uniprotkb:Ubiquitin-processing protease UBP-M(gene name synonym)|uniprotkb:MSTP039(orf name)|uniprotkb:Ubiquitin thioesterase 16(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103770|imex:IM-21965-4|dip:DIP-201587E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001992.1|refseq:NP_001027582.1|refseq:NP_006438.1|ensembl:ENSG00000156256(gene)|ensembl:ENST00000334352(transcript)|ensembl:ENST00000399976(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0140014"(mitotic nuclear division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|refseq:XP_016883746.1|refseq:XP_016883747.1|refseq:XP_016883748.1|refseq:XP_016883749.1|refseq:XP_016883750.1|dip:DIP-53761N|interpro:IPR018200|interpro:IPR028889|interpro:IPR030849|interpro:IPR038765|rcsb pdb:2I50|reactome:R-HSA-5689880|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:ParZH3MBA79ds8jMnIFj0tgS0aQ9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:b+iXHoc6FmDxZmVJ3u++wQcX6uw false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P17010 uniprotkb:Q8IWL3 intact:EBI-2818726|uniprotkb:O43668|uniprotkb:Q8WYJ8|uniprotkb:B9EG97|ensembl:ENSP00000304985|ensembl:ENSP00000368475 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:zfx_human(display_long)|uniprotkb:ZFX(gene name)|psi-mi:ZFX(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103785|imex:IM-21965-5|dip:DIP-201565E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011543881.1|refseq:XP_011543883.1|refseq:XP_006724576.1|refseq:NP_001171555.1|refseq:NP_001171556.1|refseq:NP_001171557.1|refseq:NP_003401.2|refseq:XP_005274648.1|refseq:XP_005274649.1|refseq:NP_001317256.1|refseq:XP_016885277.1|refseq:XP_016885278.1|refseq:XP_016885279.1|refseq:XP_016885280.1|refseq:XP_016885281.1|refseq:XP_016885282.1|refseq:XP_016885283.1|refseq:XP_016885284.1|dip:DIP-62116N|ensembl:ENSG00000005889(gene)|ensembl:ENST00000304543(transcript)|ensembl:ENST00000379177(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0009791"(post-embryonic development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060746"(parental behavior)|interpro:IPR006794(Zfx / Zfy transcription activation region)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:msUlErl7IIA07Mtp5C3C3QHf0YM9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:TMoYfjX2pN9RYt25neCUnh8yT3k false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P13804 uniprotkb:Q8IWL3 intact:EBI-1052886|uniprotkb:B4DT43|uniprotkb:Q53XN3|ensembl:ENSP00000452762 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:etfa_human(display_long)|uniprotkb:ETFA(gene name)|psi-mi:ETFA(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103831|imex:IM-21965-8|dip:DIP-201563E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000117.1|refseq:NP_001121188.1|dip:DIP-6161N|ensembl:ENSG00000140374(gene)|ensembl:ENST00000557943(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR001308(Electron transfer flavoprotein, alpha subunit)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014730(Electron transfer flavoprotein, alpha/beta-subunit, N-terminal)|interpro:IPR014731(Electron transfer flavoprotein, alpha subunit, C-terminal)|interpro:IPR018206|interpro:IPR029035|interpro:IPR033947|mint:P13804|rcsb pdb:1EFV|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:2A1U|reactome:R-HSA-611105 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:J2PUTTVN+nd8eHe6TXga+37CiPw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:WYu9rp66QunBdOVF/YH0eHFKa4g false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q93034 uniprotkb:Q8IWL3 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103816|imex:IM-21965-7|dip:DIP-201589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:me/nQEL4KS9UUB9PKVmYpMS3bdM false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:Q9H1K1 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103800|imex:IM-21965-6|dip:DIP-201543E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:8yUK3RkzVhed6gjqKGerxENyAac false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103800|imex:IM-21965-6|dip:DIP-201543E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:8yUK3RkzVhed6gjqKGerxENyAac false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:A6NFY7 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103846|imex:IM-21965-9|dip:DIP-201548E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:zxRgBcUD7RvDYm7vRDG7QkOdj+E false flag tag:c-c|sufficient binding region:160-235 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103846|imex:IM-21965-9|dip:DIP-201548E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:zxRgBcUD7RvDYm7vRDG7QkOdj+E false flag tag:c-c|sufficient binding region:160-235 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H672 uniprotkb:Q8IWL3 intact:EBI-3916346|uniprotkb:Q7Z4S3|uniprotkb:A8K1E5|uniprotkb:Q6GSJ6|ensembl:ENSP00000328327 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:asb7_human(display_long)|uniprotkb:ASB7(gene name)|psi-mi:ASB7(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103881|imex:IM-21965-11|dip:DIP-201588E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078984.2|refseq:NP_937886.1|ensembl:ENSG00000183475(gene)|ensembl:ENST00000332783(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036036|interpro:IPR036770|interpro:IPR037326|reactome:R-HSA-8951664|reactome:R-HSA-983168|dip:DIP-43701N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:oi6qH/JLzTvIaKcFQ+9XWnWkpTo9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:GA56R8DAziW/NRgmrSyLQpAwqcM false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103865|imex:IM-21965-10|dip:DIP-201534E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:HCwVy78NnWSLaKFplWWKPg+g/Ng false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:Q5U5X0 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-13943106|ensembl:ENSP00000368688|uniprotkb:A8MPQ9|uniprotkb:Q86Y68 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:lyrm7_human(display_long)|uniprotkb:LYRM7(gene name)|psi-mi:LYRM7(display_short)|uniprotkb:C5orf31(gene name synonym)|uniprotkb:MZM1L(gene name synonym)|uniprotkb:LYR motif-containing protein 7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103865|imex:IM-21965-10|dip:DIP-201534E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) ensembl:ENSG00000186687(gene)|ensembl:ENST00000379380(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0045333"(cellular respiration)|interpro:IPR008011(Complex 1 LYR protein)|refseq:NP_859056.2|dip:DIP-62113N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:82CB6X9AnoWIaqlhMmowBDrn5SE9606 rigid:HCwVy78NnWSLaKFplWWKPg+g/Ng false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:Q96I99 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103911|imex:IM-21965-13|dip:DIP-201535E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606 rigid:WYI0AYzwv/bnKtV38tgPAdbvseA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P42694 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1210654|uniprotkb:I6L9H4|ensembl:ENSP00000351524 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:helz_human(display_long)|uniprotkb:HELZ(gene name)|psi-mi:HELZ(display_short)|uniprotkb:KIAA0054(gene name synonym)|uniprotkb:DRHC(gene name synonym)|uniprotkb:Down-regulated in human cancers protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103911|imex:IM-21965-13|dip:DIP-201535E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055692.2|ensembl:ENSG00000198265(gene)|ensembl:ENST00000358691(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|dip:DIP-39352N|interpro:IPR027417|interpro:IPR036855|interpro:IPR041677|interpro:IPR041679 psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:q+2P+W7RDRl2CyPhdEsvONGaM0U9606 rigid:WYI0AYzwv/bnKtV38tgPAdbvseA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P16083 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-358466|uniprotkb:B2R492|ensembl:ENSP00000337773|ensembl:ENSP00000369795|ensembl:ENSP00000369822|uniprotkb:Q5TD04 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:nqo2_human(display_long)|uniprotkb:NQO2(gene name)|psi-mi:NQO2(display_short)|uniprotkb:NMOR2(gene name synonym)|uniprotkb:NRH dehydrogenase [quinone] 2(gene name synonym)|uniprotkb:"NRH:quinone oxidoreductase 2"(gene name synonym)|uniprotkb:Quinone reductase 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103911|imex:IM-21965-13|dip:DIP-201535E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) rcsb pdb:1QR2|rcsb pdb:1SG0|go:"GO:0031404"(chloride ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071949"(FAD binding)|go:"GO:1901662"(quinone catabolic process)|go:"GO:1904408"(melatonin binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905594"(resveratrol binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|refseq:NP_000895.2|ensembl:ENSG00000124588(gene)|ensembl:ENST00000338130(transcript)|ensembl:ENST00000380430(transcript)|ensembl:ENST00000380455(transcript)|go:"GO:0001512"(dihydronicotinamide riboside quinone reductase activity)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|refseq:NP_001305869.1|refseq:NP_001277150.1|rcsb pdb:1XI2|rcsb pdb:1ZX1|rcsb pdb:2BZS|rcsb pdb:2QMY|rcsb pdb:2QMZ|rcsb pdb:2QR2|rcsb pdb:2QWX|rcsb pdb:2QX4|rcsb pdb:2QX6|rcsb pdb:2QX8|rcsb pdb:2QX9|rcsb pdb:3FW1|rcsb pdb:3G5M|rcsb pdb:3GAM|rcsb pdb:3NFR|rcsb pdb:3NHF|rcsb pdb:3NHJ|rcsb pdb:3NHK|rcsb pdb:3NHL|rcsb pdb:3NHP|rcsb pdb:3NHR|rcsb pdb:3NHS|rcsb pdb:3NHW|rcsb pdb:3NHY|rcsb pdb:3O2N|rcsb pdb:3O73|rcsb pdb:3OVM|rcsb pdb:3OWH|rcsb pdb:3OWX|rcsb pdb:3OX1|rcsb pdb:3OX2|rcsb pdb:3OX3|rcsb pdb:3TE7|rcsb pdb:3TEM|rcsb pdb:3TZB|rcsb pdb:3UXE|rcsb pdb:3UXH|rcsb pdb:4FGJ|rcsb pdb:4FGK|rcsb pdb:4FGL|rcsb pdb:4GQI|rcsb pdb:4GR9|rcsb pdb:4QOD|rcsb pdb:4QOE|rcsb pdb:4QOF|rcsb pdb:4QOG|rcsb pdb:4QOH|rcsb pdb:4QOI|rcsb pdb:4QOJ|rcsb pdb:4U7F|rcsb pdb:4U7G|rcsb pdb:4U7H|rcsb pdb:4XDG|rcsb pdb:4XDH|rcsb pdb:4ZVK|rcsb pdb:4ZVL|rcsb pdb:4ZVM|rcsb pdb:4ZVN|rcsb pdb:5BUC|rcsb pdb:5LBT|rcsb pdb:5LBU|rcsb pdb:5LBW|rcsb pdb:5LBY|rcsb pdb:5LBZ|reactome:R-HSA-211945|rcsb pdb:3NHU|dip:DIP-39704N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:e23niMWdj6fUH4WR3K6sUCTM0KE9606 rigid:WYI0AYzwv/bnKtV38tgPAdbvseA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8NFA0 uniprotkb:Q8IWL3 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103896|imex:IM-21965-12|dip:DIP-201590E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:Am8fFXYKsLVpltU7KaWYbdGBgWY false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:P42694 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1210654|uniprotkb:I6L9H4|ensembl:ENSP00000351524 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:helz_human(display_long)|uniprotkb:HELZ(gene name)|psi-mi:HELZ(display_short)|uniprotkb:KIAA0054(gene name synonym)|uniprotkb:DRHC(gene name synonym)|uniprotkb:Down-regulated in human cancers protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103973|imex:IM-21965-17|dip:DIP-201536E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055692.2|ensembl:ENSG00000198265(gene)|ensembl:ENST00000358691(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|dip:DIP-39352N|interpro:IPR027417|interpro:IPR036855|interpro:IPR041677|interpro:IPR041679 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:q+2P+W7RDRl2CyPhdEsvONGaM0U9606 rigid:xu5A4V51SWggO1Mf5ngM7qy50F4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P16083 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-358466|uniprotkb:B2R492|ensembl:ENSP00000337773|ensembl:ENSP00000369795|ensembl:ENSP00000369822|uniprotkb:Q5TD04 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:nqo2_human(display_long)|uniprotkb:NQO2(gene name)|psi-mi:NQO2(display_short)|uniprotkb:NMOR2(gene name synonym)|uniprotkb:NRH dehydrogenase [quinone] 2(gene name synonym)|uniprotkb:"NRH:quinone oxidoreductase 2"(gene name synonym)|uniprotkb:Quinone reductase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15103973|imex:IM-21965-17|dip:DIP-201536E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) rcsb pdb:1QR2|rcsb pdb:1SG0|go:"GO:0031404"(chloride ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071949"(FAD binding)|go:"GO:1901662"(quinone catabolic process)|go:"GO:1904408"(melatonin binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905594"(resveratrol binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|refseq:NP_000895.2|ensembl:ENSG00000124588(gene)|ensembl:ENST00000338130(transcript)|ensembl:ENST00000380430(transcript)|ensembl:ENST00000380455(transcript)|go:"GO:0001512"(dihydronicotinamide riboside quinone reductase activity)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|refseq:NP_001305869.1|refseq:NP_001277150.1|rcsb pdb:1XI2|rcsb pdb:1ZX1|rcsb pdb:2BZS|rcsb pdb:2QMY|rcsb pdb:2QMZ|rcsb pdb:2QR2|rcsb pdb:2QWX|rcsb pdb:2QX4|rcsb pdb:2QX6|rcsb pdb:2QX8|rcsb pdb:2QX9|rcsb pdb:3FW1|rcsb pdb:3G5M|rcsb pdb:3GAM|rcsb pdb:3NFR|rcsb pdb:3NHF|rcsb pdb:3NHJ|rcsb pdb:3NHK|rcsb pdb:3NHL|rcsb pdb:3NHP|rcsb pdb:3NHR|rcsb pdb:3NHS|rcsb pdb:3NHW|rcsb pdb:3NHY|rcsb pdb:3O2N|rcsb pdb:3O73|rcsb pdb:3OVM|rcsb pdb:3OWH|rcsb pdb:3OWX|rcsb pdb:3OX1|rcsb pdb:3OX2|rcsb pdb:3OX3|rcsb pdb:3TE7|rcsb pdb:3TEM|rcsb pdb:3TZB|rcsb pdb:3UXE|rcsb pdb:3UXH|rcsb pdb:4FGJ|rcsb pdb:4FGK|rcsb pdb:4FGL|rcsb pdb:4GQI|rcsb pdb:4GR9|rcsb pdb:4QOD|rcsb pdb:4QOE|rcsb pdb:4QOF|rcsb pdb:4QOG|rcsb pdb:4QOH|rcsb pdb:4QOI|rcsb pdb:4QOJ|rcsb pdb:4U7F|rcsb pdb:4U7G|rcsb pdb:4U7H|rcsb pdb:4XDG|rcsb pdb:4XDH|rcsb pdb:4ZVK|rcsb pdb:4ZVL|rcsb pdb:4ZVM|rcsb pdb:4ZVN|rcsb pdb:5BUC|rcsb pdb:5LBT|rcsb pdb:5LBU|rcsb pdb:5LBW|rcsb pdb:5LBY|rcsb pdb:5LBZ|reactome:R-HSA-211945|rcsb pdb:3NHU|dip:DIP-39704N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:e23niMWdj6fUH4WR3K6sUCTM0KE9606 rigid:xu5A4V51SWggO1Mf5ngM7qy50F4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9HBM1 uniprotkb:Q8IWL3 intact:EBI-999909|ensembl:ENSP00000282074|ensembl:ENSP00000481354|ensembl:ENSP00000483050|uniprotkb:D3DPC0|uniprotkb:A8K4X8 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:spc25_human(display_long)|uniprotkb:AD024(orf name)|uniprotkb:SPC25(gene name)|psi-mi:SPC25(display_short)|uniprotkb:SPBC25(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103958|imex:IM-21965-16|dip:DIP-201560E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065726.1|ensembl:ENSG00000277909(gene)|ensembl:ENST00000282074(transcript)|ensembl:ENST00000611144(transcript)|ensembl:ENST00000616584(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0051301"(cell division)|interpro:IPR013255(Kinetochore-Ndc80 subunit Spc25)|mint:Q9HBM1|rcsb pdb:2VE7|rcsb pdb:3IZ0|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSG00000152253(gene)|dip:DIP-35753N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:qR1LJPKAJwXtOdzKs4Zg0PqJrBM9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:pJD4RPuB+MjTPogxbkZk2odz6TI false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H1K1 uniprotkb:P21912 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103943|imex:IM-21965-15|dip:DIP-201544E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:qyCloI2An/QjB2nkRyrYQfN1D+s false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P29084 uniprotkb:Q8IWL3 intact:EBI-2853321|uniprotkb:Q9H2B9|uniprotkb:D3DSV2|ensembl:ENSP00000348168 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:t2eb_human(display_long)|uniprotkb:GTF2E2(gene name)|psi-mi:GTF2E2(display_short)|uniprotkb:TF2E2(gene name synonym)|uniprotkb:General transcription factor IIE subunit 2(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103992|imex:IM-21965-18|dip:DIP-201561E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002086.1|refseq:XP_016868852.1|refseq:XP_016868853.1|dip:DIP-716N|ensembl:ENSG00000197265(gene)|ensembl:ENST00000355904(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005673"(transcription factor TFIIE complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016607"(nuclear speck)|interpro:IPR003166(Transcription factor TFIIE beta subunit, core)|interpro:IPR016656(Transcription initiation factor IIE, beta subunit)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040501|mint:P29084|rcsb pdb:1D8J|rcsb pdb:1D8K|rcsb pdb:5GPY|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6O9L|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:lTDT136qMQVOQf83W7wug9v9hw09606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:LrXAPaMDcg92Lopl6nFsb2Oib+g false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O95825 uniprotkb:Q8IWL3 intact:EBI-11023114|uniprotkb:B3KQ77|uniprotkb:Q9NVY7|uniprotkb:B2RDX1|uniprotkb:Q96DY0|ensembl:ENSP00000370966 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:qorl1_human(display_long)|uniprotkb:CRYZL1(gene name)|psi-mi:CRYZL1(display_short)|uniprotkb:4P11(gene name synonym)|uniprotkb:Protein 4P11(gene name synonym)|uniprotkb:Quinone oxidoreductase homolog 1(gene name synonym)|uniprotkb:Zeta-crystallin homolog(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15103928|imex:IM-21965-14|dip:DIP-201562E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_665857.2|ensembl:ENSG00000205758(gene)|ensembl:ENST00000381554(transcript)|go:"GO:0003960"("NADPH:quinone reductase activity")|go:"GO:0005829"(cytosol)|go:"GO:0050661"(NADP binding)|go:"GO:1901661"(quinone metabolic process)|interpro:IPR011032(GroES-like)|interpro:IPR020843|interpro:IPR036291|interpro:IPR042633|dip:DIP-62115N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:bQA1Rff+FLGMHDCBNWTy6zadqHY9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:qMojvd71tpxORDLaC6mFNFtLr7c false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104045|imex:IM-21965-21|dip:DIP-201545E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:WiFPwSKOCcSxUQ5a3sIV0vtOyZw false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104045|imex:IM-21965-21|dip:DIP-201545E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:WiFPwSKOCcSxUQ5a3sIV0vtOyZw false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104022|imex:IM-21965-20|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6D, 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:6EAiF7eYOaFbq6P/pfIABD+s5OQ false mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104022|imex:IM-21965-20|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6D, 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:6EAiF7eYOaFbq6P/pfIABD+s5OQ false mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104022|imex:IM-21965-20|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6D, 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:6EAiF7eYOaFbq6P/pfIABD+s5OQ false mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104022|imex:IM-21965-20|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6D, 6F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:6EAiF7eYOaFbq6P/pfIABD+s5OQ false mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P61962 uniprotkb:Q8IWL3 intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104007|imex:IM-21965-19|dip:DIP-201591E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:8k6wMAlmX3aoMljJQL5ora26BYg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NRW7 uniprotkb:Q8IWL3 intact:EBI-1782543|uniprotkb:Q15715|uniprotkb:Q9Y4Z6|uniprotkb:Q5T4P6|uniprotkb:F5H8K1|uniprotkb:Q53FR8|uniprotkb:D3DUZ9|ensembl:ENSP00000495563 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:vps45_human(display_long)|uniprotkb:VPS45(gene name)|psi-mi:VPS45(display_short)|uniprotkb:VPS45A(gene name synonym)|uniprotkb:VPS45B(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104063|imex:IM-21965-22|dip:DIP-201582E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-46823N|refseq:NP_009190.2|refseq:NP_001266282.1|refseq:NP_001266283.1|ensembl:ENSG00000136631(gene)|ensembl:ENST00000644510(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|reactome:R-HSA-6811438|reactome:R-HSA-983231 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:EO8eXkh8EW/0AN2p5OqHL4yvXV09606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:Gw4XwLIVPSRuVgSS37xZ4xdilpc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104078|imex:IM-21965-23|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 7A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false sufficient binding region:255-280|mutation disrupting interaction strength:267-268|mutation disrupting interaction:276-277 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104099|imex:IM-21965-24|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104099|imex:IM-21965-24|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false ha tag:?-? mutation disrupting interaction:102-104 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104099|imex:IM-21965-24|dip:DIP-201546E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 3G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false ha tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q04900 uniprotkb:Q8IWL3 intact:EBI-2115896|uniprotkb:Q5JSU6|uniprotkb:E1P5E8|uniprotkb:E1P5E7|uniprotkb:E1P5E9|uniprotkb:B4DQ85|uniprotkb:O95413|uniprotkb:Q9BPV0|uniprotkb:Q9NR26|ensembl:ENSP00000309376 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:muc24_human(display_long)|uniprotkb:Endolyn(gene name synonym)|uniprotkb:CD164(gene name)|psi-mi:CD164(display_short)|uniprotkb:Multi-glycosylated core protein 24(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104121|imex:IM-21965-25|dip:DIP-201604E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135873.1|refseq:NP_001135874.1|refseq:NP_001135875.1|refseq:NP_001135876.1|refseq:NP_006007.2|refseq:NP_001333429.1|dip:DIP-43970N|ensembl:ENSG00000135535(gene)|ensembl:ENST00000310786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0030097"(hemopoiesis)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR007947(CD164 related protein)|mint:Q04900 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:RnECOHDDKJ98oN/MPUzPHIwRePs9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:nW/aVDRTlL78tOsjcDCzn3RlE4I false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:Q8IWL3 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104136|imex:IM-21965-26|dip:DIP-201537E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:URvyGdsK6u+HneeaIGViyUD+XYE false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104136|imex:IM-21965-26|dip:DIP-201537E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:URvyGdsK6u+HneeaIGViyUD+XYE false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P07814 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104136|imex:IM-21965-26|dip:DIP-201537E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 rigid:URvyGdsK6u+HneeaIGViyUD+XYE false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14103 uniprotkb:Q8IWL3 intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104156|imex:IM-21965-27|dip:DIP-201570E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:iJ5YDW6FWmGZYVroTJjq8HBOLVg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96QE3 uniprotkb:Q8IWL3 intact:EBI-10980241|ensembl:ENSP00000313171|uniprotkb:Q05DH0|uniprotkb:Q9H9I1|uniprotkb:Q69YR6 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:atad5_human(display_long)|uniprotkb:ATAD5(gene name)|psi-mi:ATAD5(display_short)|uniprotkb:C17orf41(gene name synonym)|uniprotkb:Chromosome fragility-associated gene 1 protein(gene name synonym)|uniprotkb:FRAG1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104171|imex:IM-21965-28|dip:DIP-201568E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079133.3|ensembl:ENSG00000176208(gene)|ensembl:ENST00000321990(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0061860"(DNA clamp unloader activity)|go:"GO:0090618"(DNA clamp unloading)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|mint:Q96QE3|dip:DIP-62118N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:RykTLq8koh3X5KGZI8THhWttHcE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:+UZPg/8n/IpCUXnSxDTpHZr6Yjs false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P38646 uniprotkb:Q9H1K1 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104186|imex:IM-21965-29|dip:DIP-201545E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:WiFPwSKOCcSxUQ5a3sIV0vtOyZw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:P21912 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0276"(blue native page) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104186|imex:IM-21965-29|dip:DIP-201545E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:WiFPwSKOCcSxUQ5a3sIV0vtOyZw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86SX6 uniprotkb:Q8IWL3 intact:EBI-1049910|uniprotkb:Q3YML0|uniprotkb:Q86WY3|uniprotkb:Q8IZ54|uniprotkb:Q0X088|ensembl:ENSP00000328570 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:glrx5_human(display_long)|uniprotkb:GLRX5(gene name)|psi-mi:GLRX5(display_short)|uniprotkb:C14orf87(gene name synonym)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104202|imex:IM-21965-30|dip:DIP-201551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057501.2|ensembl:ENSG00000182512(gene)|ensembl:ENST00000331334(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|rcsb pdb:2MMZ|rcsb pdb:2WUL|reactome:R-HSA-1362409|dip:DIP-50654N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:+h1VgIFt6kuH/Mc+KUxkB+w9RJI9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:pJHK7BBFct/xnljjirm54qE5t00 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23526 uniprotkb:Q8IWL3 intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104217|imex:IM-21965-31|dip:DIP-201603E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:aG0127CNcSXTpR8NQjEtJtRg7wc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UM13 uniprotkb:Q8IWL3 intact:EBI-1266437|uniprotkb:Q2V500|uniprotkb:Q9UG51|uniprotkb:Q9Y5R0|uniprotkb:D3DNZ7|ensembl:ENSP00000310071|ensembl:ENSP00000403891|ensembl:ENSP00000423995|ensembl:ENSP00000478501 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:apc10_human(display_long)|uniprotkb:ANAPC10(gene name)|psi-mi:ANAPC10(display_short)|uniprotkb:APC10(gene name synonym)|uniprotkb:Cyclosome subunit 10(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104232|imex:IM-21965-32|dip:DIP-201583E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055700.2|refseq:NP_001305296.1|refseq:NP_001243635.1|refseq:NP_001243636.1|refseq:NP_001243637.1|refseq:NP_001243638.1|refseq:NP_001243639.1|refseq:XP_011529826.1|dip:DIP-39885N|ensembl:ENSG00000164162(gene)|ensembl:ENST00000309439(transcript)|ensembl:ENST00000451299(transcript)|ensembl:ENST00000507656(transcript)|ensembl:ENST00000613466(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR016901(Anaphase-promoting complex, subunit 10, subgroup)|mint:Q9UM13|rcsb pdb:1JHJ|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|rcsb pdb:6TLJ refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:kKLo92DrTuOsaeowcNSWKe7xyn49606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:FcNHV4QwnMxXCqdlPqXTpnRbCkg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96QD9 uniprotkb:Q8IWL3 intact:EBI-724553|uniprotkb:Q96SL9|uniprotkb:Q9BQI8|uniprotkb:A8MY74|uniprotkb:B2RCB2|uniprotkb:B7Z3R4|uniprotkb:B7Z7V1|uniprotkb:B7Z8I0|uniprotkb:B7ZAJ3|uniprotkb:C9J7P6|uniprotkb:C9JNG6|uniprotkb:C9JTH3|uniprotkb:C9JY50|ensembl:ENSP00000241502 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:uif_human(display_long)|uniprotkb:UIF(gene name synonym)|uniprotkb:FYTTD1(gene name)|psi-mi:FYTTD1(display_short)|uniprotkb:Forty-two-three domain-containing protein 1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104247|imex:IM-21965-33|dip:DIP-201569E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001011537.2|refseq:NP_115664.2|ensembl:ENSG00000122068(gene)|ensembl:ENST00000241502(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016607"(nuclear speck)|interpro:IPR009782(Protein of unknown function DUF1346)|mint:Q96QD9|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|dip:DIP-62119N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:mMARxli9v/w8ggb5tjd/5hvSxnI9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:kUT19dmO64kLuoXQRYo175EmGP0 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9P2J3 uniprotkb:Q8IWL3 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104262|imex:IM-21965-34|dip:DIP-201585E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:1FZqJtFMm3KWkxivUPDa8E+kDws false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P12004 uniprotkb:Q8IWL3 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104277|imex:IM-21965-35|dip:DIP-201567E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:DwJRp+ynIK32en1Qgamia59TbS8 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P07814 uniprotkb:Q8IWL3 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104292|imex:IM-21965-36|dip:DIP-201538E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:PvC2AMumZTVItbweu4ELNclSoLE false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:A6NFY7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104310|imex:IM-21965-37|dip:DIP-201549E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rigid:ILQ30qMVMKLtfllyrKw4S2ln4aM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104310|imex:IM-21965-37|dip:DIP-201549E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6G|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:ILQ30qMVMKLtfllyrKw4S2ln4aM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P20248 uniprotkb:Q8IWL3 intact:EBI-457097|ensembl:ENSP00000274026|uniprotkb:Q2M3U6|uniprotkb:Q4W5P4|uniprotkb:Q6LER8|uniprotkb:A8K7B6 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ccna2_human(display_long)|uniprotkb:Cyclin A(gene name synonym)|uniprotkb:CCNA2(gene name)|psi-mi:CCNA2(display_short)|uniprotkb:CCN1(gene name synonym)|uniprotkb:CCNA(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104326|imex:IM-21965-38|dip:DIP-201584E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145386(gene)|ensembl:ENST00000274026(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|refseq:NP_001228.1|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|mint:P20248|rcsb pdb:1E9H|rcsb pdb:1FIN|rcsb pdb:1H1P|rcsb pdb:1FVV|rcsb pdb:1GY3|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P5E|rcsb pdb:1PKD|rcsb pdb:1QMZ|rcsb pdb:1URC|rcsb pdb:1VYW|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2C4G|rcsb pdb:6SG4|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7LUO|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:2CJM|rcsb pdb:2WIH|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2UUE|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3F5X|rcsb pdb:4BCK|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2V22|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCP|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:6Q6H|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4FX3|rcsb pdb:5CYI|rcsb pdb:5IF1|rcsb pdb:5LMK|rcsb pdb:5NEV|rcsb pdb:6ATH|rcsb pdb:6RIJ|rcsb pdb:6GVA|rcsb pdb:6P3W|rcsb pdb:6Q6G|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|dip:DIP-638N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:eAkF93loT7w//7jrIC/Nlpy5iVc9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:0Zh7c5NhyUgI4y3MjbdVRRYim5s false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:Q9H1K1 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104341|imex:IM-21965-39|dip:DIP-201540E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:g6LcN5Fe1GbbGZHsdO/BOFLuRts false sufficient binding region:160-235|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P21912 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104341|imex:IM-21965-39|dip:DIP-201540E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:g6LcN5Fe1GbbGZHsdO/BOFLuRts false sufficient binding region:160-235|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N3X1 uniprotkb:Q8IWL3 intact:EBI-310600|uniprotkb:Q9H985|uniprotkb:Q9NT81|uniprotkb:Q9Y2L7|ensembl:ENSP00000263773|ensembl:ENSP00000494562 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:fnbp4_human(display_long)|uniprotkb:KIAA1014(gene name synonym)|uniprotkb:FNBP4(gene name)|psi-mi:FNBP4(display_short)|uniprotkb:Formin-binding protein 30(gene name synonym)|uniprotkb:FBP30(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104362|imex:IM-21965-40|dip:DIP-201586E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001305268.1|refseq:NP_056123.2|ensembl:ENSP00000263773|ensembl:ENSP00000494562|ensembl:ENSG00000109920(gene)|ensembl:ENSG00000285182(gene)|ensembl:ENST00000263773(transcript)|ensembl:ENST00000646180(transcript)|go:"GO:0016607"(nuclear speck)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|dip:DIP-31674N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:+OrXOka8nsdXcudO76FI6qGXGPI9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:CxTygaPEY3ov16yuEaAxTlvbFOY false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A6NFY7 uniprotkb:P21912 intact:EBI-12011488|ensembl:ENSP00000368165|uniprotkb:B2RPM7 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:sdhf1_human(display_long)|uniprotkb:SDHAF1(gene name)|psi-mi:SDHAF1(display_short)|uniprotkb:LYR motif-containing protein 8(gene name synonym)|uniprotkb:LYRM8(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104377|imex:IM-21965-41|dip:DIP-201550E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000205138(gene)|ensembl:ENST00000378887(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0034553"(mitochondrial respiratory chain complex II assembly)|interpro:IPR008011(Complex 1 LYR protein)|dip:DIP-62123N|refseq:NP_001036096.1 refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 5F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:P6MKaJaP6EffNUZtgj4/S9UxuTE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:sDLwmKPtY56NcbnTT8ETRDfyN9E false - sufficient binding region:147-280|flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P42694 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1210654|uniprotkb:I6L9H4|ensembl:ENSP00000351524 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:helz_human(display_long)|uniprotkb:HELZ(gene name)|psi-mi:HELZ(display_short)|uniprotkb:KIAA0054(gene name synonym)|uniprotkb:DRHC(gene name synonym)|uniprotkb:Down-regulated in human cancers protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104397|imex:IM-21965-42|dip:DIP-201536E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055692.2|ensembl:ENSG00000198265(gene)|ensembl:ENST00000358691(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|dip:DIP-39352N|interpro:IPR027417|interpro:IPR036855|interpro:IPR041677|interpro:IPR041679 psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:q+2P+W7RDRl2CyPhdEsvONGaM0U9606 rigid:xu5A4V51SWggO1Mf5ngM7qy50F4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:Q8IWL3 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104397|imex:IM-21965-42|dip:DIP-201536E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xu5A4V51SWggO1Mf5ngM7qy50F4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P16083 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-358466|uniprotkb:B2R492|ensembl:ENSP00000337773|ensembl:ENSP00000369795|ensembl:ENSP00000369822|uniprotkb:Q5TD04 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:nqo2_human(display_long)|uniprotkb:NQO2(gene name)|psi-mi:NQO2(display_short)|uniprotkb:NMOR2(gene name synonym)|uniprotkb:NRH dehydrogenase [quinone] 2(gene name synonym)|uniprotkb:"NRH:quinone oxidoreductase 2"(gene name synonym)|uniprotkb:Quinone reductase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104397|imex:IM-21965-42|dip:DIP-201536E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) rcsb pdb:1QR2|rcsb pdb:1SG0|go:"GO:0031404"(chloride ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071949"(FAD binding)|go:"GO:1901662"(quinone catabolic process)|go:"GO:1904408"(melatonin binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905594"(resveratrol binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|refseq:NP_000895.2|ensembl:ENSG00000124588(gene)|ensembl:ENST00000338130(transcript)|ensembl:ENST00000380430(transcript)|ensembl:ENST00000380455(transcript)|go:"GO:0001512"(dihydronicotinamide riboside quinone reductase activity)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|refseq:NP_001305869.1|refseq:NP_001277150.1|rcsb pdb:1XI2|rcsb pdb:1ZX1|rcsb pdb:2BZS|rcsb pdb:2QMY|rcsb pdb:2QMZ|rcsb pdb:2QR2|rcsb pdb:2QWX|rcsb pdb:2QX4|rcsb pdb:2QX6|rcsb pdb:2QX8|rcsb pdb:2QX9|rcsb pdb:3FW1|rcsb pdb:3G5M|rcsb pdb:3GAM|rcsb pdb:3NFR|rcsb pdb:3NHF|rcsb pdb:3NHJ|rcsb pdb:3NHK|rcsb pdb:3NHL|rcsb pdb:3NHP|rcsb pdb:3NHR|rcsb pdb:3NHS|rcsb pdb:3NHW|rcsb pdb:3NHY|rcsb pdb:3O2N|rcsb pdb:3O73|rcsb pdb:3OVM|rcsb pdb:3OWH|rcsb pdb:3OWX|rcsb pdb:3OX1|rcsb pdb:3OX2|rcsb pdb:3OX3|rcsb pdb:3TE7|rcsb pdb:3TEM|rcsb pdb:3TZB|rcsb pdb:3UXE|rcsb pdb:3UXH|rcsb pdb:4FGJ|rcsb pdb:4FGK|rcsb pdb:4FGL|rcsb pdb:4GQI|rcsb pdb:4GR9|rcsb pdb:4QOD|rcsb pdb:4QOE|rcsb pdb:4QOF|rcsb pdb:4QOG|rcsb pdb:4QOH|rcsb pdb:4QOI|rcsb pdb:4QOJ|rcsb pdb:4U7F|rcsb pdb:4U7G|rcsb pdb:4U7H|rcsb pdb:4XDG|rcsb pdb:4XDH|rcsb pdb:4ZVK|rcsb pdb:4ZVL|rcsb pdb:4ZVM|rcsb pdb:4ZVN|rcsb pdb:5BUC|rcsb pdb:5LBT|rcsb pdb:5LBU|rcsb pdb:5LBW|rcsb pdb:5LBY|rcsb pdb:5LBZ|reactome:R-HSA-211945|rcsb pdb:3NHU|dip:DIP-39704N psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:e23niMWdj6fUH4WR3K6sUCTM0KE9606 rigid:xu5A4V51SWggO1Mf5ngM7qy50F4 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15696 uniprotkb:Q8IWL3 intact:EBI-6657923|ensembl:ENSP00000303015|uniprotkb:Q14D69 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:u2afm_human(display_long)|uniprotkb:ZRSR2(gene name)|psi-mi:ZRSR2(display_short)|uniprotkb:CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-20(gene name synonym)|uniprotkb:"U2(RNU2) small nuclear RNA auxiliary factor 1-like 2"(gene name synonym)|uniprotkb:U2AF1-RS2(gene name synonym)|uniprotkb:U2AF1L2(gene name synonym)|uniprotkb:U2AF1RS2(gene name synonym)|uniprotkb:U2AF35-related protein(gene name synonym)|uniprotkb:URP(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104417|imex:IM-21965-43|dip:DIP-201566E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169249(gene)|ensembl:ENST00000307771(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0030628"(pre-mRNA 3'-splice site binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0089701"(U2AF complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR009145(U2 auxiliary factor small subunit)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|reactome:R-HSA-72165|go:"GO:0042802"(identical protein binding)|dip:DIP-62117N|refseq:NP_005080.1 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:F/pwj2ZqRutuCgfyKmvoVLWwHzo9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:jZJmGd+IlIw2PBT/18a2kLcJF7U false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P38646 uniprotkb:Q8IWL3 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104432|imex:IM-21965-44|dip:DIP-201542E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:sb41B8lQC/utD/Rs1Ttpn4xm6DM false - sufficient binding region:1-159|flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5U5X0 uniprotkb:Q8IWL3 intact:EBI-13943106|ensembl:ENSP00000368688|uniprotkb:A8MPQ9|uniprotkb:Q86Y68 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:lyrm7_human(display_long)|uniprotkb:LYRM7(gene name)|psi-mi:LYRM7(display_short)|uniprotkb:C5orf31(gene name synonym)|uniprotkb:MZM1L(gene name synonym)|uniprotkb:LYR motif-containing protein 7(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104452|imex:IM-21965-45|dip:DIP-201554E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000186687(gene)|ensembl:ENST00000379380(transcript)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034551"(mitochondrial respiratory chain complex III assembly)|go:"GO:0045333"(cellular respiration)|interpro:IPR008011(Complex 1 LYR protein)|refseq:NP_859056.2|dip:DIP-62113N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:82CB6X9AnoWIaqlhMmowBDrn5SE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:jUd0+ZiN3V3fHqWI0gzg05dBWZ4 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00422 uniprotkb:Q8IWL3 intact:EBI-1044156|uniprotkb:Q2TTR4|uniprotkb:Q6IAW9|uniprotkb:Q8N606|uniprotkb:Q9UF14|ensembl:ENSP00000475925|uniprotkb:B2R494|uniprotkb:X6RAL5 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sap18_human(display_long)|uniprotkb:18 kDa Sin3-associated polypeptide(gene name synonym)|uniprotkb:Sin3-associated polypeptide p18(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 38 protein(gene name synonym)|uniprotkb:2HOR0202(gene name synonym)|uniprotkb:SAP18(gene name)|psi-mi:SAP18(display_short)|uniprotkb:GIG38(orf name) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104467|imex:IM-21965-46|dip:DIP-201575E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000150459(gene)|ensembl:ENST00000607003(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR010516(Sin3 associated polypeptide p18)|interpro:IPR017250(Histone deacetylase complex, SAP18 subunit)|interpro:IPR042534|mint:O00422|rcsb pdb:2HDE|reactome:R-HSA-3214815|reactome:R-HSA-427413|reactome:R-HSA-9679191|refseq:NP_005861.2|dip:DIP-33590N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:eJoksFCc7vBoAjJEpnXJvc/yg+Q9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:/Vj4eagujxR+m+7+XUiFZdcPI6U false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104482|imex:IM-21965-47|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false flag tag:c-c|mutation disrupting interaction:166-166|mutation decreasing interaction strength:220-221|mutation disrupting interaction strength:220-220,166-166,162-162|mutation disrupting interaction strength:221-221,166-166,162-162 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:Q9H1K1 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104482|imex:IM-21965-47|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false flag tag:c-c|mutation disrupting interaction:166-166|mutation decreasing interaction strength:220-221|mutation disrupting interaction strength:220-220,166-166,162-162|mutation disrupting interaction strength:221-221,166-166,162-162 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P21912 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104482|imex:IM-21965-47|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false flag tag:c-c|mutation disrupting interaction:166-166|mutation decreasing interaction strength:220-221|mutation disrupting interaction strength:220-220,166-166,162-162|mutation disrupting interaction strength:221-221,166-166,162-162 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104530|imex:IM-21965-49|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false flag tag:c-c - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104515|imex:IM-21965-48|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1, Fig.1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false sufficient binding region:115-280 sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q13873 uniprotkb:Q8IWL3 intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104548|imex:IM-21965-50|dip:DIP-201598E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:YtMiPnsbzDtV2HOA6Tarkr52Q5w false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9H3P7 uniprotkb:Q8IWL3 intact:EBI-1791792|uniprotkb:Q5VTJ0|uniprotkb:Q6P9F1|uniprotkb:Q8IZC5|uniprotkb:Q8N4D6|uniprotkb:Q9H6U3|uniprotkb:B2RB29|ensembl:ENSP00000355777 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:gcp60_human(display_long)|uniprotkb:GOCAP1(gene name synonym)|uniprotkb:GOLPH1(gene name synonym)|uniprotkb:ACBD3(gene name)|psi-mi:ACBD3(display_short)|uniprotkb:GCP60(gene name synonym)|uniprotkb:Acyl-CoA-binding domain-containing protein 3(gene name synonym)|uniprotkb:Golgi phosphoprotein 1(gene name synonym)|uniprotkb:Golgi complex-associated protein 1(gene name synonym)|uniprotkb:PBR- and PKA-associated protein 7(gene name synonym)|uniprotkb:Peripheral benzodiazepine receptor-associated protein PAP7(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104744|imex:IM-21965-51|dip:DIP-201599E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_073572.2|dip:DIP-40673N|ensembl:ENSG00000182827(gene)|ensembl:ENST00000366812(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR009038(GOLD)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR022408|interpro:IPR035984|interpro:IPR036598|mint:Q9H3P7|rcsb pdb:2N72|rcsb pdb:2N73|rcsb pdb:5LZ1|rcsb pdb:5LZ3|rcsb pdb:5LZ6|rcsb pdb:5TDQ|rcsb pdb:6HLN|rcsb pdb:6HLT|rcsb pdb:6HLV|rcsb pdb:6HLW|rcsb pdb:6HM8|rcsb pdb:6HMV|reactome:R-HSA-432722 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:jAaMXnoXG6RGj+lAgIYk1inXA6o9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:G8qwJ885KB1FSm+8Kjvej2g5Q4Q false sufficient binding region:29-235 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P07814 uniprotkb:Q8IWL3 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104759|imex:IM-21965-52|dip:DIP-201538E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:PvC2AMumZTVItbweu4ELNclSoLE false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75376 uniprotkb:Q8IWL3 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104774|imex:IM-21965-53|dip:DIP-201574E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:Mzy1USmiwznnl2PvlrEiHImh8B4 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104837|imex:IM-21965-57|dip:DIP-201539E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:SGnoMq4i7PIFwNFEOTclmlflhl8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104837|imex:IM-21965-57|dip:DIP-201539E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:SGnoMq4i7PIFwNFEOTclmlflhl8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UBT7 uniprotkb:Q8IWL3 intact:EBI-514206|uniprotkb:O76084|uniprotkb:Q53FQ2|uniprotkb:Q5JTQ7|uniprotkb:Q5JTQ8|uniprotkb:Q9Y401|uniprotkb:B5BU47|ensembl:ENSP00000320434 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ctnl1_human(display_long)|uniprotkb:Catenin alpha-like protein 1(gene name synonym)|uniprotkb:Alpha-catenin-related protein(gene name synonym)|uniprotkb:CTNNAL1(gene name)|psi-mi:CTNNAL1(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104822|imex:IM-21965-56|dip:DIP-201600E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003789.1|refseq:NP_001273903.1|dip:DIP-33236N|ensembl:ENSG00000119326(gene)|ensembl:ENST00000325551(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030045|interpro:IPR036723|mint:Q9UBT7 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:4XpDxeBmUk7NAT/aAAhl0c8Sc1w9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:RQ6u0Y1GLEJQRle6io5nadWgPQk false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P78415 uniprotkb:Q8IWL3 intact:EBI-14034782|uniprotkb:Q7Z4A4|uniprotkb:Q7Z4A5|uniprotkb:Q8IVC6|ensembl:ENSP00000331608 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:irx3_human(display_long)|uniprotkb:IRX3(gene name)|psi-mi:IRX3(display_short)|uniprotkb:IRXB1(gene name synonym)|uniprotkb:Homeodomain protein IRXB1(gene name synonym)|uniprotkb:Iroquois homeobox protein 3(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104807|imex:IM-21965-55|dip:DIP-201573E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077312.2|ensembl:ENSG00000177508(gene)|ensembl:ENST00000329734(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0003165"(Purkinje myocyte development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0060932"(His-Purkinje system cell differentiation)|go:"GO:0072086"(specification of loop of Henle identity)|go:"GO:0097009"(energy homeostasis)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR003893(Iroquois-class homeodomain protein)|interpro:IPR008422(Coprinus cinereus mating-type protein)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|dip:DIP-62120N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:XEfMLGov7qqH8NH8Tf5HEScRFyw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:eCswJCB2d2pK6uHytbynhiHgWLc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104789|imex:IM-21965-54|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false flag tag:c-c - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWL3 uniprotkb:Q86SX6 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1049910|uniprotkb:Q3YML0|uniprotkb:Q86WY3|uniprotkb:Q8IZ54|uniprotkb:Q0X088|ensembl:ENSP00000328570 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:glrx5_human(display_long)|uniprotkb:GLRX5(gene name)|psi-mi:GLRX5(display_short)|uniprotkb:C14orf87(gene name synonym)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104853|imex:IM-21965-58|dip:DIP-201552E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_057501.2|ensembl:ENSG00000182512(gene)|ensembl:ENST00000331334(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|rcsb pdb:2MMZ|rcsb pdb:2WUL|reactome:R-HSA-1362409|dip:DIP-50654N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:+h1VgIFt6kuH/Mc+KUxkB+w9RJI9606 rigid:5ttanLA60GY49ZJ3tZRYDKugrTY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P38646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104853|imex:IM-21965-58|dip:DIP-201552E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:5ttanLA60GY49ZJ3tZRYDKugrTY false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q58WW2 uniprotkb:Q8IWL3 intact:EBI-2559044|ensembl:ENSP00000311949|uniprotkb:Q8TB19|uniprotkb:Q8IXH3|uniprotkb:A2A295|uniprotkb:Q7L8I0|uniprotkb:B4DNB8 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:dcaf6_human(display_long)|uniprotkb:DCAF6(gene name)|psi-mi:DCAF6(display_short)|uniprotkb:IQWD1(gene name synonym)|uniprotkb:Nuclear receptor interaction protein(gene name synonym)|uniprotkb:IQ motif and WD repeat-containing protein 1(gene name synonym)|uniprotkb:Androgen receptor complex-associated protein(gene name synonym)|uniprotkb:MSTP055(orf name) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104887|imex:IM-21965-60|dip:DIP-201572E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143164(gene)|ensembl:ENST00000312263(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030374"(nuclear receptor coactivator activity)|refseq:NP_001017977.1|refseq:NP_001185885.1|refseq:NP_001185886.1|refseq:NP_060912.2|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q58WW2|rcsb pdb:3I7O|reactome:R-HSA-8951664|dip:DIP-44678N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:1CtoPWPj6fdryvDlC46pXiUguDc9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:bGe6rSjIH3mmJlbuqcMhfS8LHm4 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P20827 uniprotkb:Q8IWL3 intact:EBI-715194|uniprotkb:Q5SR60|uniprotkb:Q5SR61|uniprotkb:Q6I9T9|uniprotkb:Q8N578|ensembl:ENSP00000357392|uniprotkb:D3DV86 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:efna1_human(display_long)|uniprotkb:EPH-related receptor tyrosine kinase ligand 1(gene name synonym)|uniprotkb:Immediate early response protein B61(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 4(gene name synonym)|uniprotkb:EFNA1(gene name)|psi-mi:EFNA1(display_short)|uniprotkb:EPLG1(gene name synonym)|uniprotkb:LERK1(gene name synonym)|uniprotkb:TNFAIP4(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104872|imex:IM-21965-59|dip:DIP-201601E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004419.2|refseq:NP_872626.1|ensembl:ENSG00000169242(gene)|ensembl:ENST00000368407(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003199"(endocardial cushion to mesenchymal transition involved in heart valve formation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007411"(axon guidance)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014028"(notochord formation)|go:"GO:0016477"(cell migration)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034252|mint:P20827|rcsb pdb:3CZU|rcsb pdb:3HEI|rcsb pdb:3MBW|reactome:R-HSA-2682334|reactome:R-HSA-3928663|reactome:R-HSA-3928665|dip:DIP-98N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:buRAXjFXXzsg7OXYzU5snuQy5w09606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:h8nDocMOmHQvPNdOOMrvFslHGsc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104918|imex:IM-21965-62|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false sufficient binding region:104-280 sufficient binding region:158-177|sufficient binding region:175-235 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWL3 uniprotkb:Q9H1K1 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104902|imex:IM-21965-61|dip:DIP-201540E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:g6LcN5Fe1GbbGZHsdO/BOFLuRts false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:P21912 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15104902|imex:IM-21965-61|dip:DIP-201540E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:g6LcN5Fe1GbbGZHsdO/BOFLuRts false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104939|imex:IM-21965-63|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IWL3 uniprotkb:Q8IWL3 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104969|imex:IM-21965-65|dip:DIP-201553E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:G6Ywypu1R1blGPAR/LI/8H1TxbQ false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q8TCS8 uniprotkb:Q8IWL3 intact:EBI-1052020|uniprotkb:Q53SU0|uniprotkb:Q68CN1|uniprotkb:Q7Z7D1|uniprotkb:Q8IWX1|uniprotkb:Q96T05|uniprotkb:Q9BRU3|uniprotkb:Q9BVX0|ensembl:ENSP00000393953|ensembl:ENSP00000400646 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:pnpt1_human(display_long)|uniprotkb:Polynucleotide phosphorylase 1(gene name synonym)|uniprotkb:Polynucleotide phosphorylase-like protein(gene name synonym)|uniprotkb:PNPase old-35(gene name synonym)|uniprotkb:3'-5' RNA exonuclease OLD35(gene name synonym)|uniprotkb:PNPT1(gene name)|psi-mi:PNPT1(display_short)|uniprotkb:PNPASE(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104954|imex:IM-21965-64|dip:DIP-201571E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_149100.2|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071042"(nuclear polyadenylation-dependent mRNA catabolic process)|go:"GO:0097222"(mitochondrial mRNA polyadenylation)|go:"GO:0097421"(liver regeneration)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR003029(S1, RNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012162(Polyribonucleotide nucleotidyltransferase)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR015848(Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type)|interpro:IPR020568|interpro:IPR022967|interpro:IPR027408|interpro:IPR036345|interpro:IPR036456|interpro:IPR036612|rcsb pdb:3U1K|rcsb pdb:5ZF6|ensembl:ENSG00000138035(gene)|ensembl:ENST00000415374(transcript)|ensembl:ENST00000447944(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000957"(mitochondrial RNA catabolic process)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0000962"(positive regulation of mitochondrial RNA catabolic process)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0000965"(mitochondrial RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0034046"("poly(G) binding")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035927"(RNA import into mitochondrion)|go:"GO:0035928"(rRNA import into mitochondrion)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043631"(RNA polyadenylation)|go:"GO:0045025"(mitochondrial degradosome)|go:"GO:0004654"(polyribonucleotide nucleotidyltransferase activity)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060416"(response to growth hormone)|dip:DIP-50226N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:W9hr1vfWv1b0v4xfMYatfKfOMcg9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:+LLa1vUYcuY8CYN2ARVRi+pN0Rk false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q0VDF9 uniprotkb:Q8IWL3 intact:EBI-8773684|uniprotkb:A8K8F8|uniprotkb:B0YIY9|uniprotkb:Q9P0X2|uniprotkb:Q9UI07|ensembl:ENSP00000367623 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:hsp7e_human(display_long)|uniprotkb:HSPA14(gene name)|psi-mi:HSPA14(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:HSP70L1(gene name synonym)|uniprotkb:HSP70-like protein 1(gene name synonym)|uniprotkb:Heat shock protein HSP60(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104999|imex:IM-21965-67|dip:DIP-201558E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057383.2|ensembl:ENSG00000187522(gene)|ensembl:ENST00000378372(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051083"('de novo' cotranslational protein folding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR042049|interpro:IPR043129|mint:Q0VDF9|reactome:R-HSA-3371453|dip:DIP-62114N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:RNKKz93Uww+GkRXdvnm5QY8h+lM9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:4QWN+k3InUbUofMQ4/fcxsAYnIg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q92905 uniprotkb:Q8IWL3 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15104984|imex:IM-21965-66|dip:DIP-201602E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:ZjTXlGevocux1FhUfoEqB/Zf+rc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P38646 uniprotkb:Q9H1K1 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105014|imex:IM-21965-68|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:P21912 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105014|imex:IM-21965-68|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:Q8IWL3 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105014|imex:IM-21965-68|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) intact:EBI-14034924 uniprotkb:Q8IWL3 - intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:abcab_human(display_short)|psi-mi:EBI-14034924(display_long)|uniprotkb:ABCA11P(gene name)|psi-mi:ABCA11P(display_short)|uniprotkb:ABCA11(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105031|imex:IM-21965-69|dip:DIP-201592E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q4W5N1(uniprot-removed-ac) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:KPXhul/Elb+OaT0LNscI9qFuxJw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:SGQTgc9+yMYKerxCqS/cUqADutI false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P09132 uniprotkb:Q8IWL3 intact:EBI-2680090|uniprotkb:B2R4E9|uniprotkb:Q96FG6|uniprotkb:Q05D77|uniprotkb:D6RCQ5|ensembl:ENSP00000424870 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:srp19_human(display_long)|uniprotkb:SRP19(gene name)|psi-mi:SRP19(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105061|imex:IM-21965-71|dip:DIP-201580E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001191123.1|refseq:NP_003126.1|refseq:NP_001191122.1|refseq:NP_001191125.1|ensembl:ENSG00000153037(gene)|ensembl:ENST00000505459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006617"(SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition)|go:"GO:0008312"(7S RNA binding)|go:"GO:0048500"(signal recognition particle)|interpro:IPR002778(Signal recognition particle, SRP19 subunit)|interpro:IPR036521|mint:P09132|rcsb pdb:1JID|rcsb pdb:1MFQ|rcsb pdb:1RY1|rcsb pdb:2J37|rcsb pdb:3KTV|rcsb pdb:4P3E|rcsb pdb:5M73|rcsb pdb:7NFX|reactome:R-HSA-1799339|dip:DIP-41412N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:yIFmf1q6m2wQt3eaiCc1dlIQXn89606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:qSLRUNY4WV1f0BNLLPTHyMLSfSg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9UNK0 uniprotkb:Q8IWL3 intact:EBI-727240|uniprotkb:O60712|uniprotkb:Q53XT8|ensembl:ENSP00000305255 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:stx8_human(display_long)|uniprotkb:STX8(gene name)|psi-mi:STX8(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105046|imex:IM-21965-70|dip:DIP-201581E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004844.1|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR041875|mint:Q9UNK0|ensembl:ENSG00000170310(gene)|ensembl:ENST00000306357(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|dip:DIP-47274N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:jdsUOdy99aWRb94ndPtawff7z/o9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:vtWQ9SgLiYrX0q8cm1D4Cv8jpyQ false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P54709 uniprotkb:Q8IWL3 intact:EBI-1054481|uniprotkb:B7Z1N7|ensembl:ENSP00000286371 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:at1b3_human(display_long)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-3(gene name synonym)|uniprotkb:ATP1B3(gene name)|psi-mi:ATP1B3(display_short) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105097|imex:IM-21965-73|dip:DIP-201593E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001670.1|ensembl:ENSG00000069849(gene)|ensembl:ENST00000286371(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0005901"(caveola)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042470"(melanosome)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086009"(membrane repolarization)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR038702|mint:P54709|reactome:R-HSA-210991|reactome:R-HSA-5578775|reactome:R-HSA-936837|reactome:R-HSA-9679191|dip:DIP-50717N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:M7gSVe1bjKF7LqCZh/raoHBvp7M9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:st5pdJx/rRdnfninMtYzvx9cxMg false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105076|imex:IM-21965-72|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false sufficient binding region:237-258|mutation disrupting interaction strength:240-240 binding-associated region:29-235 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TDQ7 uniprotkb:Q8IWL3 intact:EBI-10275006|uniprotkb:Q96NC6|uniprotkb:Q59EA7|uniprotkb:Q96BJ4|uniprotkb:Q8NCZ8|uniprotkb:B4DJF3|uniprotkb:Q2VYF1|ensembl:ENSP00000295448 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:gnpi2_human(display_long)|uniprotkb:GNPDA2(gene name)|psi-mi:GNPDA2(display_short)|uniprotkb:GNP2(gene name synonym)|uniprotkb:Glucosamine-6-phosphate deaminase 2(gene name synonym)|uniprotkb:Glucosamine-6-phosphate isomerase SB52(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105112|imex:IM-21965-74|dip:DIP-201594E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001257809.1|refseq:NP_001257810.1|refseq:NP_612208.1|interpro:IPR004547(Glucosamine-6-phosphate isomerase)|interpro:IPR006148(Glucosamine/galactosamine-6-phosphate isomerase)|interpro:IPR018321|interpro:IPR037171|reactome:R-HSA-70171|go:"GO:0042802"(identical protein binding)|ensembl:ENSG00000163281(gene)|ensembl:ENST00000295448(transcript)|go:"GO:0004342"(glucosamine-6-phosphate deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006043"(glucosamine catabolic process)|go:"GO:0006046"(N-acetylglucosamine catabolic process)|go:"GO:0006048"(UDP-N-acetylglucosamine biosynthetic process)|go:"GO:0019262"(N-acetylneuraminate catabolic process)|dip:DIP-62122N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:NwV1EvWzFUt9pxUyR5iYOG/OmZA9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:krG6zWysL7tmZnJ8Cw9GMcTtpw8 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O60884 uniprotkb:Q8IWL3 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105127|imex:IM-21965-75|dip:DIP-201559E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:84eN2FK2GCTwLRnBuVpiHzqiRGo false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105142|imex:IM-21965-76|dip:DIP-201533E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:95zVA3C1ZlfGzhKwQ5pidxj3+VM false sufficient binding region:35-52|mutation disrupting interaction strength:44-44 binding-associated region:29-235 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00425 uniprotkb:Q8IWL3 intact:EBI-1058566|ensembl:ENSP00000258729|uniprotkb:Q63HM0|uniprotkb:A0A4Z5|uniprotkb:Q6MZZ2|uniprotkb:Q86VB1|intact:EBI-2560196 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:if2b3_human(display_long)|uniprotkb:IGF2BP3(gene name)|psi-mi:IGF2BP3(display_short)|uniprotkb:IMP3(gene name synonym)|uniprotkb:KOC1(gene name synonym)|uniprotkb:VICKZ3(gene name synonym)|uniprotkb:IGF-II mRNA-binding protein 3(gene name synonym)|uniprotkb:KH domain-containing protein overexpressed in cancer(gene name synonym)|uniprotkb:VICKZ family member 3(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105163|imex:IM-21965-77|dip:DIP-201579E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136231(gene)|ensembl:ENST00000258729(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|refseq:NP_006538.2|interpro:IPR004087(K Homology)|dip:DIP-44171N|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034844|interpro:IPR035979|interpro:IPR036612|mint:O00425|rcsb pdb:2E44|rcsb pdb:6FQ1|rcsb pdb:6FQR|rcsb pdb:6GQE|rcsb pdb:6GX6|reactome:R-HSA-428359 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:yGEnYHFP+P05J45ZnHUdcPXHlQA9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:++Djq3CSpF4ZtGbaUFnabzw6DNI false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y6M1 uniprotkb:Q8IWL3 intact:EBI-1024419|intact:EBI-1059063|intact:EBI-1237206|uniprotkb:A0A4Z0|uniprotkb:B3FTN2|uniprotkb:B3FTN3|uniprotkb:B3FTN4|ensembl:ENSP00000371634 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:if2b2_human(display_long)|uniprotkb:IGF-II mRNA-binding protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma autoantigen p62(gene name synonym)|uniprotkb:VICKZ family member 2(gene name synonym)|uniprotkb:IGF2BP2(gene name)|psi-mi:IGF2BP2(display_short)|uniprotkb:IMP2(gene name synonym)|uniprotkb:VICKZ2(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105178|imex:IM-21965-78|dip:DIP-201578E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278801.1|refseq:NP_001278802.1|refseq:NP_001278803.1|refseq:NP_001278804.1|refseq:NP_001007226.1|refseq:NP_006539.3|ensembl:ENSG00000073792(gene)|ensembl:ENST00000382199(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007399"(nervous system development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051252"(regulation of RNA metabolic process)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR028743|interpro:IPR034843|interpro:IPR035979|interpro:IPR036612|mint:Q9Y6M1|rcsb pdb:2CQH|rcsb pdb:6ROL|reactome:R-HSA-428359|dip:DIP-35539N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:k45UViReMAxCv2cu7+tx+auevQc9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:ONvMIYApViKXq38pQIZh/5veLdI false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9NTK5 uniprotkb:Q8IWL3 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105217|imex:IM-21965-80|dip:DIP-201595E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:mb00My1j0uO1g+VY8qzz9hVl15M false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P21912 uniprotkb:P31040 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105193|imex:IM-21965-79|dip:DIP-201547E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N psi-mi:"MI:0465"(dip) - - figure legend:Fig 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 rigid:rkavGvI/mAZ2nexVRM4MPkyYlI8 false mutation disrupting interaction:46-46|mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105193|imex:IM-21965-79|dip:DIP-201547E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Fig 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:rkavGvI/mAZ2nexVRM4MPkyYlI8 false mutation disrupting interaction:46-46|mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105193|imex:IM-21965-79|dip:DIP-201547E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig 6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:rkavGvI/mAZ2nexVRM4MPkyYlI8 false mutation disrupting interaction:46-46|mutation disrupting interaction strength:44-46|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:Q8IWL3 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0276"(blue native page) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105232|imex:IM-21965-81|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:Q9H1K1 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0276"(blue native page) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105232|imex:IM-21965-81|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P38646 uniprotkb:P21912 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:"MI:0276"(blue native page) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105232|imex:IM-21965-81|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P16083 uniprotkb:Q8IWL3 intact:EBI-358466|uniprotkb:B2R492|ensembl:ENSP00000337773|ensembl:ENSP00000369795|ensembl:ENSP00000369822|uniprotkb:Q5TD04 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:nqo2_human(display_long)|uniprotkb:NQO2(gene name)|psi-mi:NQO2(display_short)|uniprotkb:NMOR2(gene name synonym)|uniprotkb:NRH dehydrogenase [quinone] 2(gene name synonym)|uniprotkb:"NRH:quinone oxidoreductase 2"(gene name synonym)|uniprotkb:Quinone reductase 2(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105249|imex:IM-21965-82|dip:DIP-201555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1QR2|rcsb pdb:1SG0|go:"GO:0031404"(chloride ion binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071949"(FAD binding)|go:"GO:1901662"(quinone catabolic process)|go:"GO:1904408"(melatonin binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905594"(resveratrol binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003680(Flavodoxin-like fold)|interpro:IPR029039|refseq:NP_000895.2|ensembl:ENSG00000124588(gene)|ensembl:ENST00000338130(transcript)|ensembl:ENST00000380430(transcript)|ensembl:ENST00000380455(transcript)|go:"GO:0001512"(dihydronicotinamide riboside quinone reductase activity)|go:"GO:0003955"("NAD(P)H dehydrogenase (quinone) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016661"(oxidoreductase activity, acting on other nitrogenous compounds as donors)|refseq:NP_001305869.1|refseq:NP_001277150.1|rcsb pdb:1XI2|rcsb pdb:1ZX1|rcsb pdb:2BZS|rcsb pdb:2QMY|rcsb pdb:2QMZ|rcsb pdb:2QR2|rcsb pdb:2QWX|rcsb pdb:2QX4|rcsb pdb:2QX6|rcsb pdb:2QX8|rcsb pdb:2QX9|rcsb pdb:3FW1|rcsb pdb:3G5M|rcsb pdb:3GAM|rcsb pdb:3NFR|rcsb pdb:3NHF|rcsb pdb:3NHJ|rcsb pdb:3NHK|rcsb pdb:3NHL|rcsb pdb:3NHP|rcsb pdb:3NHR|rcsb pdb:3NHS|rcsb pdb:3NHW|rcsb pdb:3NHY|rcsb pdb:3O2N|rcsb pdb:3O73|rcsb pdb:3OVM|rcsb pdb:3OWH|rcsb pdb:3OWX|rcsb pdb:3OX1|rcsb pdb:3OX2|rcsb pdb:3OX3|rcsb pdb:3TE7|rcsb pdb:3TEM|rcsb pdb:3TZB|rcsb pdb:3UXE|rcsb pdb:3UXH|rcsb pdb:4FGJ|rcsb pdb:4FGK|rcsb pdb:4FGL|rcsb pdb:4GQI|rcsb pdb:4GR9|rcsb pdb:4QOD|rcsb pdb:4QOE|rcsb pdb:4QOF|rcsb pdb:4QOG|rcsb pdb:4QOH|rcsb pdb:4QOI|rcsb pdb:4QOJ|rcsb pdb:4U7F|rcsb pdb:4U7G|rcsb pdb:4U7H|rcsb pdb:4XDG|rcsb pdb:4XDH|rcsb pdb:4ZVK|rcsb pdb:4ZVL|rcsb pdb:4ZVM|rcsb pdb:4ZVN|rcsb pdb:5BUC|rcsb pdb:5LBT|rcsb pdb:5LBU|rcsb pdb:5LBW|rcsb pdb:5LBY|rcsb pdb:5LBZ|reactome:R-HSA-211945|rcsb pdb:3NHU|dip:DIP-39704N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:e23niMWdj6fUH4WR3K6sUCTM0KE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:OChdhsjTGU55sRLAYxrvoZRIJJY false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O00330 uniprotkb:Q8IWL3 intact:EBI-751566|uniprotkb:O60221|uniprotkb:Q96FV8|uniprotkb:Q99783|uniprotkb:D3DR11|uniprotkb:E9PB14|uniprotkb:B4DW62|uniprotkb:E9PBP7|ensembl:ENSP00000227868 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:odpx_human(display_long)|uniprotkb:Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:Lipoyl-containing pyruvate dehydrogenase complex component X(gene name synonym)|uniprotkb:E3-binding protein(gene name synonym)|uniprotkb:proX(gene name synonym)|uniprotkb:PDHX(gene name)|psi-mi:PDHX(display_short)|uniprotkb:PDX1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105264|imex:IM-21965-83|dip:DIP-201596E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001128496.1|refseq:NP_001159630.1|refseq:NP_003468.2|dip:DIP-29026N|ensembl:ENSG00000110435(gene)|ensembl:ENST00000227868(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:O00330|rcsb pdb:1ZY8|rcsb pdb:2DNC|rcsb pdb:2F5Z|rcsb pdb:2F60|rcsb pdb:6H60|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:fcQCBKmyySLi0lr+SQKUkPy+rwE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:Hf2gqh6/vmjCdb10umw1iZGJTcc false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q969S9 uniprotkb:Q8IWL3 intact:EBI-2371750|uniprotkb:Q8WYI0|uniprotkb:A0AR28|uniprotkb:Q8N6D8|uniprotkb:Q9H6Z1|intact:EBI-28986334|ensembl:ENSP00000296805|ensembl:ENSP00000427004 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:rrf2m_human(display_long)|uniprotkb:GFM2(gene name)|psi-mi:GFM2(display_short)|uniprotkb:EFG2(gene name synonym)|uniprotkb:Elongation factor G 2, mitochondrial(gene name synonym)|uniprotkb:Elongation factor G2(gene name synonym)|uniprotkb:MSTP027(orf name) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105279|imex:IM-21965-84|dip:DIP-201577E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_115756.2|refseq:NP_733781.1|refseq:NP_733792.1|ensembl:ENST00000345239|ensembl:ENSP00000296804|ensembl:ENST00000427854|ensembl:ENSP00000405808|ensembl:ENSP00000427004|ensembl:ENSP00000296805|refseq:NP_001268231.1|refseq:XP_016865475.1|dip:DIP-53437N|ensembl:ENSG00000164347(gene)|ensembl:ENST00000296805(transcript)|ensembl:ENST00000509430(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006414"(translational elongation)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0070126"(mitochondrial translational termination)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009022(Elongation factor G, III and V)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR030851|interpro:IPR031157|interpro:IPR035647|interpro:IPR035649|interpro:IPR041095|mint:Q969S9|rcsb pdb:7L20|rcsb pdb:7NSH|reactome:R-HSA-5419276 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:tDdVCBcztI95aArJCyypUgUrWOw9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:QpEtOPVW/fWDMGWprZKNZ7RP1O4 false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96I99 uniprotkb:Q8IWL3 intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105294|imex:IM-21965-85|dip:DIP-201557E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:RvehtkHmU04vM0ZmvOZV71EKAlI false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P38646 uniprotkb:Q8IWL3 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105309|imex:IM-21965-86|dip:DIP-201542E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp. Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:sb41B8lQC/utD/Rs1Ttpn4xm6DM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q9H1K1 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1047335|uniprotkb:Q6P713|uniprotkb:Q99617|uniprotkb:Q9H1K2|ensembl:ENSP00000310623 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:iscu_human(display_long)|uniprotkb:NifU-like N-terminal domain-containing protein(gene name synonym)|uniprotkb:ISCU(gene name)|psi-mi:ISCU(display_short)|uniprotkb:NIFUN(gene name synonym)|uniprotkb:NifU-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105324|imex:IM-21965-87|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_055116.1|refseq:NP_998760.1|refseq:NP_001306971.1|dip:DIP-39616N|ensembl:ENSG00000136003(gene)|ensembl:ENST00000311893(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1904439"(negative regulation of iron ion import across plasma membrane)|interpro:IPR002871(NIF system FeS cluster assembly, NifU, N-terminal)|interpro:IPR011339(ISC system FeS cluster assembly, IscU scaffold)|mint:Q9H1K1|rcsb pdb:5KZ5|rcsb pdb:5WKP|rcsb pdb:5WLW|rcsb pdb:6NZU|rcsb pdb:6UXE|rcsb pdb:6W1D|rcsb pdb:6WI2|rcsb pdb:6WIH|reactome:R-HSA-1362409|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1904234"(positive regulation of aconitate hydratase activity) psi-mi:"MI:0465"(dip) - - figure legend:Supp FIg. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:/4n8Oot3LAX0qwANOsPFL8sDtrE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false sufficient binding region:1-147|sufficient binding region:147-280|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:P38646 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-354932|ensembl:ENSP00000297185|uniprotkb:P30036|uniprotkb:P31932|uniprotkb:Q6GU03|uniprotkb:Q9BWB7|uniprotkb:B2RCM1|uniprotkb:Q1HB43|uniprotkb:Q53H23|uniprotkb:Q9UC56 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:grp75_human(display_long)|uniprotkb:HSPA9(gene name)|psi-mi:HSPA9(display_short)|uniprotkb:GRP75(gene name synonym)|uniprotkb:HSPA9B(gene name synonym)|uniprotkb:75 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 9(gene name synonym)|uniprotkb:Peptide-binding protein 74(gene name synonym)|uniprotkb:Mortalin(gene name synonym)|uniprotkb:mt-HSP70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105324|imex:IM-21965-87|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N reactome:R-HSA-8949613|reactome:R-HSA-8950505|ensembl:ENSG00000113013(gene)|ensembl:ENST00000297185(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005925"(focal adhesion)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0140275"(MIB complex)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1903707"(negative regulation of hemopoiesis)|interpro:IPR012725(Chaperone DnaK)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|go:"GO:0070062"(extracellular exosome)|interpro:IPR043129|mint:P38646|rcsb pdb:3N8E|rcsb pdb:4KBO|rcsb pdb:6NHK|rcsb pdb:6P2U|rcsb pdb:6PMT|reactome:R-HSA-1268020|reactome:R-HSA-3371453|refseq:NP_004125.3|dip:DIP-32936N psi-mi:"MI:0465"(dip) - - figure legend:Supp FIg. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:xjSHeTKBb/lH1XNEEiMIjsM+XcE9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false sufficient binding region:1-147|sufficient binding region:147-280|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P21912 uniprotkb:Q8IWL3 intact:EBI-1056481|uniprotkb:Q9NQ12|uniprotkb:Q0QEY7|uniprotkb:B2R545|ensembl:ENSP00000364649 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:sdhb_human(display_long)|uniprotkb:SDHB(gene name)|psi-mi:SDHB(display_short)|uniprotkb:SDH(gene name synonym)|uniprotkb:SDH1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15105324|imex:IM-21965-87|dip:DIP-201541E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002991.2|ensembl:ENSG00000117118(gene)|ensembl:ENST00000375499(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-39666N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp FIg. 5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/06/16 2017/06/19 rogid:7xnswe3IVEFJiXqGhxF0Az3EmvE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:xv3wz8oScvS/Iv+Jdfvo1oUYvSY false sufficient binding region:1-147|sufficient binding region:147-280|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P42694 uniprotkb:Q8IWL3 intact:EBI-1210654|uniprotkb:I6L9H4|ensembl:ENSP00000351524 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:helz_human(display_long)|uniprotkb:HELZ(gene name)|psi-mi:HELZ(display_short)|uniprotkb:KIAA0054(gene name synonym)|uniprotkb:DRHC(gene name synonym)|uniprotkb:Down-regulated in human cancers protein(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105363|imex:IM-21965-89|dip:DIP-201556E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055692.2|ensembl:ENSG00000198265(gene)|ensembl:ENST00000358691(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|dip:DIP-39352N|interpro:IPR027417|interpro:IPR036855|interpro:IPR041677|interpro:IPR041679 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:q+2P+W7RDRl2CyPhdEsvONGaM0U9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:faEhiJWCtvxdKDFCSvpCRyWfA+M false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q96RS0 uniprotkb:Q8IWL3 intact:EBI-949244|ensembl:ENSP00000260129|uniprotkb:A6NJQ5|uniprotkb:Q5GH23|uniprotkb:Q8TDG9|uniprotkb:Q96QU3|uniprotkb:Q9H5V3|intact:EBI-2563555 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:tgs1_human(display_long)|uniprotkb:Cap-specific guanine-N2 methyltransferase(gene name synonym)|uniprotkb:Nuclear receptor coactivator 6-interacting protein(gene name synonym)|uniprotkb:PRIP-interacting protein with methyltransferase motif(gene name synonym)|uniprotkb:CLL-associated antigen KW-2(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 137(gene name synonym)|uniprotkb:TGS1(gene name)|psi-mi:TGS1(display_short)|uniprotkb:PIMT(gene name synonym)|uniprotkb:HCA137(gene name synonym)|uniprotkb:NCOA6IP(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105348|imex:IM-21965-88|dip:DIP-201576E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000137574(gene)|ensembl:ENST00000260129(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0009452"(7-methylguanosine RNA capping)|go:"GO:0015030"(Cajal body)|go:"GO:0022613"(ribonucleoprotein complex biogenesis)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0036261"(7-methylguanosine cap hypermethylation)|go:"GO:0071164"(RNA trimethylguanosine synthase activity)|interpro:IPR019012|interpro:IPR029063|rcsb pdb:3EGI|rcsb pdb:3GDH|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-191859|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:NP_079107.6|refseq:NP_001304831.1|dip:DIP-49970N refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:K72Uc4b54997Kq/gZWB5NMPfLVk9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:KVr+kNi8sJal1T/WzJ5YkFeIU5s false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P36871 uniprotkb:Q8IWL3 intact:EBI-2861475|uniprotkb:Q5BKZ9|uniprotkb:Q96J40|uniprotkb:Q9NTY4|uniprotkb:Q6NW22|uniprotkb:Q86U74|uniprotkb:Q16105|uniprotkb:B2R5N9|uniprotkb:B4DPV0|uniprotkb:Q16106|ensembl:ENSP00000360125 intact:EBI-1805738|uniprotkb:Q9BWS7|ensembl:ENSP00000216027 psi-mi:pgm1_human(display_long)|uniprotkb:PGM1(gene name)|psi-mi:PGM1(display_short)|uniprotkb:Glucose phosphomutase 1(gene name synonym) psi-mi:hsc20_human(display_long)|uniprotkb:HSCB(gene name)|psi-mi:HSCB(display_short)|uniprotkb:DNAJC20(gene name synonym)|uniprotkb:HSC20(gene name synonym)|uniprotkb:DnaJ homolog subfamily C member 20(gene name synonym) psi-mi:"MI:0018"(two hybrid) Maio et al. (2014) pubmed:24606901|doi:10.1016/j.cmet.2014.01.015|imex:IM-21965 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15105378|imex:IM-21965-90|dip:DIP-201597E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166289.1|refseq:NP_001166290.1|refseq:NP_002624.2|dip:DIP-60903N|reactome:R-HSA-5609974|reactome:R-HSA-6798695|reactome:R-HSA-3322077|ensembl:ENSG00000079739(gene)|ensembl:ENST00000371084(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004614"(phosphoglucomutase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005841(Alpha-D-phosphohexomutase, N-terminal)|interpro:IPR005843(Alpha-D-phosphohexomutase, C-terminal)|interpro:IPR005844(Alpha-D-phosphohexomutase, alpha/beta/alpha domain I)|interpro:IPR005845(Alpha-D-phosphohexomutase, alpha/beta/alpha domain II)|interpro:IPR005846(Alpha-D-phosphohexomutase, alpha/beta/alpha domain III)|interpro:IPR016055(Alpha-D-phosphohexomutase, alpha/beta/alpha I, II and III)|interpro:IPR016066(Alpha-D-phosphohexomutase, conserved site)|interpro:IPR036900|rcsb pdb:5EPC|rcsb pdb:5F9C|rcsb pdb:5HSH|rcsb pdb:5JN5|rcsb pdb:5TR2|rcsb pdb:5VBI|rcsb pdb:5VEC|rcsb pdb:5VG7|rcsb pdb:5VIN|rcsb pdb:6SNO|rcsb pdb:6SNP|rcsb pdb:6SNQ|rcsb pdb:6UIQ|rcsb pdb:6UO6 refseq:NP_741999.3|dip:DIP-46570N|go:"GO:0042802"(identical protein binding)|go:"GO:0044571"([2Fe-2S] cluster assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR004640(Co-chaperone Hsc20)|interpro:IPR009073(Heat shock cognate protein B, C-terminal oligomerisation)|go:"GO:0016226"(iron-sulfur cluster assembly)|interpro:IPR036386|interpro:IPR036869|interpro:IPR040682|rcsb pdb:3BVO|reactome:R-HSA-1268020|reactome:R-HSA-1362409|ensembl:ENSG00000100209(gene)|ensembl:ENST00000216027(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol) psi-mi:"MI:0465"(dip) - - figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/06/16 2017/06/19 rogid:K9cGu3lfysJ4hVP0S0jewZsZjSE9606 rogid:7LEm+s/QM9R2FExi4iPC8OMp54Y9606 rigid:gqRk8e/xcjzBKYWV7rL7jY2Oj5Y false - sufficient binding region:29-235 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)