#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P03495 uniprotkb:P03495 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Aramini et al. (2014) pubmed:24582435|doi:10.1016/j.str.2014.01.010|imex:IM-22662 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16094705|imex:IM-22662-1|dip:DIP-196440E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rigid:zMwT4KP23kiMb/FJoc3npNMb8cY false sufficient binding region:85-215 sufficient binding region:85-215 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P03495 uniprotkb:P03495 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Aramini et al. (2014) pubmed:24582435|doi:10.1016/j.str.2014.01.010|imex:IM-22662 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16094723|imex:IM-22662-2|dip:DIP-196440E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rigid:zMwT4KP23kiMb/FJoc3npNMb8cY false sufficient binding region:85-215|mutation:183-183,116-116 sufficient binding region:85-215|mutation:183-183,116-116 - 0 psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P03495 uniprotkb:P03495 intact:EBI-2548993|uniprotkb:Q1K9D5 intact:EBI-2548993|uniprotkb:Q1K9D5 psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:ns1_i72a2(display_long)|uniprotkb:NS(gene name)|psi-mi:NS(display_short)|uniprotkb:NS1A(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Aramini et al. (2014) pubmed:24582435|doi:10.1016/j.str.2014.01.010|imex:IM-22662 taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") taxid:381517(i72a2)|taxid:381517("Influenza A virus (strain A/Udorn/307/1972 H3N2)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16094746|imex:IM-22662-3|dip:DIP-196440E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N go:"GO:0052038"(modulation by symbiont of host intracellular transport)|go:"GO:0052170"(suppression by symbiont of host innate immune response)|interpro:IPR000256("Influenza non-structural protein (NS1)")|go:"GO:0046775"(suppression by virus of host cytokine production)|interpro:IPR004208("Influenza B non-structural protein (NS1)")|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR038064|rcsb pdb:1AIL|rcsb pdb:1NS1|rcsb pdb:2KKZ|rcsb pdb:2RHK|rcsb pdb:3EE8|rcsb pdb:3EE9|rcsb pdb:3KWG|rcsb pdb:3KWI|rcsb pdb:4NW2|rcsb pdb:4O45|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0019056"(modulation by virus of host transcription)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039524"(suppression by virus of host mRNA processing)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|dip:DIP-46282N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rogid:VyosjYP0De3Y+BRJoOxL/BcF3NU381517 rigid:zMwT4KP23kiMb/FJoc3npNMb8cY false sufficient binding region:85-215|mutation disrupting interaction strength:110-110|5'-fluoro-L-tryptophan:187-187 sufficient binding region:85-215|mutation disrupting interaction strength:110-110|5'-fluoro-L-tryptophan:187-187 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)