#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q5NCS9 uniprotkb:Q8K1M6-3 intact:EBI-16092669|ensembl:ENSMUSP00000018743 intact:EBI-16092613|ensembl:ENSMUSP00000023477 psi-mi:mid49_mouse(display_long)|uniprotkb:Mief2(gene name)|psi-mi:Mief2(display_short)|uniprotkb:Gm11(gene name synonym)|uniprotkb:Mid49(gene name synonym)|uniprotkb:Smcr7(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 49 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 2(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog(gene name synonym) psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:"MI:0419"(gtpase assay) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092694|imex:IM-22332-4|dip:DIP-195826E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000018599(gene)|ensembl:ENSMUST00000018743(transcript)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4WOY|refseq:NP_001009927.1|dip:DIP-60661N intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ZDdmujtvU0LyOTzPl7T0sZ8bWdQ10090 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rigid:Tzv0JTMEKAglhG+4S9uzw5RSt2U false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K1M6-3 uniprotkb:Q8K1M6-3 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092613|ensembl:ENSMUSP00000023477 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092653|imex:IM-22332-3|dip:DIP-195827E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rigid:pb43llO83I3+GYnwytiHwPY89uc false - - - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K1M6-3 uniprotkb:Q8BGV8 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0018"(two hybrid) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16092621|imex:IM-22332-2|dip:DIP-195825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:8BqIG6R2AuslqSPBY+WXY4W8UOA false - mutation disrupting interaction strength:237-237,235-235,234-234|mutation decreasing interaction strength:243-243,240-240,239-239|mutation disrupting interaction strength:255-255,254-254,253-253 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGV8 uniprotkb:Q8BGV8 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092595|imex:IM-22332-1|dip:DIP-195824E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:awfNZvrZ6gjrptDwSEhHdw7HUO8 false sufficient binding region:134-463 sufficient binding region:134-463 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8BGV8 uniprotkb:Q8BGV8 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16092711|imex:IM-22332-5|dip:DIP-195824E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:lbf33WaihpqGduuPAQhx/mfXlm4 false green fluorescent protein tag:c-c myc tag:c-c|mutation decreasing interaction strength:169-169|mutation decreasing interaction strength:183-183,182-182|mutation decreasing interaction strength:182-182|mutation disrupting interaction strength:213-213,212-212,183-183,182-182,169-169 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8K1M6-3 uniprotkb:Q8BGV8 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0419"(gtpase assay) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092800|imex:IM-22332-9|dip:DIP-195825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:8BqIG6R2AuslqSPBY+WXY4W8UOA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5NCS9 uniprotkb:Q8K1M6-3 intact:EBI-16092669|ensembl:ENSMUSP00000018743 intact:EBI-16092613|ensembl:ENSMUSP00000023477 psi-mi:mid49_mouse(display_long)|uniprotkb:Mief2(gene name)|psi-mi:Mief2(display_short)|uniprotkb:Gm11(gene name synonym)|uniprotkb:Mid49(gene name synonym)|uniprotkb:Smcr7(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 49 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 2(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog(gene name synonym) psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092783|imex:IM-22332-8|dip:DIP-195826E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000018599(gene)|ensembl:ENSMUST00000018743(transcript)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4WOY|refseq:NP_001009927.1|dip:DIP-60661N intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ZDdmujtvU0LyOTzPl7T0sZ8bWdQ10090 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rigid:Tzv0JTMEKAglhG+4S9uzw5RSt2U false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8K1M6-3 uniprotkb:Q8BGV8 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0020"(transmission electron microscopy) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092766|imex:IM-22332-7|dip:DIP-195825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:8BqIG6R2AuslqSPBY+WXY4W8UOA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K1M6-3 uniprotkb:Q8BGV8 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092749|imex:IM-22332-6|dip:DIP-195825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:8BqIG6R2AuslqSPBY+WXY4W8UOA false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q8K1M6-3 uniprotkb:Q8BGV8 intact:EBI-16092613|ensembl:ENSMUSP00000023477 intact:EBI-16092561|ensembl:ENSMUSP00000023048|ensembl:ENSMUSP00000129209|ensembl:ENSMUSP00000154875|uniprotkb:Q8C4Y9 psi-mi:q8k1m6-3(display_long)|uniprotkb:Dnm1l(gene name)|psi-mi:Dnm1l(display_short)|uniprotkb:Drp1(gene name synonym)|uniprotkb:Dynamin family member proline-rich carboxyl-terminal domain less(gene name synonym)|uniprotkb:Dynamin-related protein 1(gene name synonym) psi-mi:mid51_mouse(display_long)|uniprotkb:Mief1(gene name)|psi-mi:Mief1(display_short)|uniprotkb:Mid51(gene name synonym)|uniprotkb:Smcr7l(gene name synonym)|uniprotkb:Mitochondrial dynamics protein of 51 kDa homolog(gene name synonym)|uniprotkb:Mitochondrial elongation factor 1(gene name synonym)|uniprotkb:Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Losón et al. (2014) pubmed:24508339|doi:10.1016/j.str.2014.01.001|imex:IM-22332 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16092817|imex:IM-22332-10|dip:DIP-195825E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2365792(isoform-parent)|ensembl:ENSMUSG00000022789(gene)|ensembl:ENSMUST00000023477(transcript) ensembl:ENSMUSG00000022412(gene)|ensembl:ENSMUST00000023048(transcript)|ensembl:ENSMUST00000166030(transcript)|ensembl:ENSMUST00000229138(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR024810|rcsb pdb:4OAF|rcsb pdb:4OAG|rcsb pdb:4OAH|rcsb pdb:4OAI|refseq:NP_848834.2|refseq:XP_006521009.1|refseq:XP_006521010.1|dip:DIP-60660N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ZVS7ZScJZXzokKQo3oAY+qqf3YU10090 rogid:3cQjgT1MkpjNcIRiO6TrgEbCm5Y10090 rigid:8BqIG6R2AuslqSPBY+WXY4W8UOA false - mutation disrupting interaction strength:237-237,235-235,234-234|mutation disrupting interaction strength:243-243,240-240,239-239|myc tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)