#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0AE88 uniprotkb:P0AE82 intact:EBI-550918|uniprotkb:P16244|uniprotkb:P76777|uniprotkb:Q2M8K9|ensemblbacteria:AAC76894|ensemblbacteria:BAE77397 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 psi-mi:cpxr_ecoli(display_long)|uniprotkb:cpxR(gene name)|psi-mi:cpxR(display_short)|uniprotkb:b3912(locus name)|uniprotkb:JW3883(locus name)|uniprotkb:yiiA(gene name synonym) psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:"MI:0424"(protein kinase assay) Mechaly et al. (2014) pubmed:24492262|doi:10.1371/journal.pbio.1001776|imex:IM-22347 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092087|imex:IM-22347-1|dip:DIP-102626E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_418348.1|refseq:WP_001033722.1|dip:DIP-47991N|ensemblbacteria:AAC76894(transcript)|ensemblbacteria:b3912(gene)|ensemblbacteria:BAE77397(gene)|ensemblbacteria:BAE77397(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0007155"(cell adhesion)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|rcsb pdb:4UHJ|rcsb pdb:4UHK|rcsb pdb:4UHS|rcsb pdb:4UHT refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:u3h2TvzCoHYIIFj0quTYacwG6XA83333 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rigid:V97a8cU46a6Ly8df1fDx2/AFkIg false sufficient binding region:1-115 mutation disrupting interaction rate:228-228 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P0AE82 uniprotkb:P0AE82 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:"MI:0114"(x-ray crystallography) Mechaly et al. (2014) pubmed:24492262|doi:10.1371/journal.pbio.1001776|imex:IM-22347 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092133|imex:IM-22347-3|dip:DIP-195867E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rigid:+QmlP7I0AdJtZIJlKLGbIDOQRkk false sufficient binding region:188-457 sufficient binding region:188-457 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0AE82 uniprotkb:P0AE82 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:"MI:0826"(x ray scattering) Mechaly et al. (2014) pubmed:24492262|doi:10.1371/journal.pbio.1001776|imex:IM-22347 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092109|imex:IM-22347-2|dip:DIP-195867E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rigid:+QmlP7I0AdJtZIJlKLGbIDOQRkk false sufficient binding region:188-457 sufficient binding region:188-457 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0AE82 uniprotkb:P0AE82 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 intact:EBI-9141330|uniprotkb:P08336|uniprotkb:Q2M8K8|ensemblbacteria:AAC76893|ensemblbacteria:BAE77398 psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:cpxa_ecoli(display_long)|uniprotkb:ecfB(gene name synonym)|uniprotkb:eup(gene name synonym)|uniprotkb:ssd(gene name synonym)|uniprotkb:JW3882(locus name)|uniprotkb:b3911(locus name)|uniprotkb:cpxA(gene name)|psi-mi:cpxA(display_short) psi-mi:"MI:0424"(protein kinase assay) Mechaly et al. (2014) pubmed:24492262|doi:10.1371/journal.pbio.1001776|imex:IM-22347 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16092151|imex:IM-22347-4|dip:DIP-195867E - - psi-mi:"MI:0898"(putative self) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK refseq:NP_418347.1|refseq:WP_000580417.1|dip:DIP-48358N|ensemblbacteria:AAC76893(transcript)|ensemblbacteria:b3911(gene)|ensemblbacteria:BAE77398(gene)|ensemblbacteria:BAE77398(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0036460"(cellular response to cell envelope stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0043708"(cell adhesion involved in biofilm formation)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR032404|interpro:IPR036097|interpro:IPR036890|interpro:IPR038515|rcsb pdb:4BIU|rcsb pdb:4BIV|rcsb pdb:4BIW|rcsb pdb:4BIX|rcsb pdb:4BIY|rcsb pdb:4BIZ|rcsb pdb:4CB0|rcsb pdb:5LFK psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rogid:nDNOrWUaSHtaAtgUKUfIIq5+EIg83333 rigid:+QmlP7I0AdJtZIJlKLGbIDOQRkk false sufficient binding region:188-457|mutation decreasing interaction rate:228-228 sufficient binding region:188-457|mutation decreasing interaction rate:228-228 - 0 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)