#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O08807 uniprotkb:Q8NBS9-1 intact:EBI-494652|uniprotkb:Q3U8E4|uniprotkb:B1AZS7|ensembl:ENSMUSP00000026328 intact:EBI-16091651|ensembl:ENSP00000369081 psi-mi:prdx4_mouse(display_long)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)|uniprotkb:Prdx4(gene name)|psi-mi:Prdx4(display_short) psi-mi:q8nbs9-1(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name) psi-mi:"MI:0114"(x-ray crystallography) Kojima et al. (2014) pubmed:24462249|doi:10.1016/j.str.2013.12.013|imex:IM-22330 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16091660|imex:IM-22330-1|dip:DIP-195823E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058044.1|refseq:NP_001300640.1|dip:DIP-34137N|ensembl:ENSMUSG00000025289(gene)|ensembl:ENSMUST00000026328(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:O08807|rcsb pdb:3VWU|rcsb pdb:3VWV|rcsb pdb:3W8J|rcsb pdb:3WGX|reactome:R-MMU-6798695 intact:EBI-2510815(isoform-parent)|ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:86EzEedrO6v5Z2dnSB2fSPaV2hc10090 rogid:bz5VVWMPFLTRKwph60UFASjsFN49606 rigid:SDDpZckQVkmUJFqEIamhWCa+BtU false sufficient binding region:244-263 sufficient binding region:190-298 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O08807 uniprotkb:Q8NBS9-1 intact:EBI-494652|uniprotkb:Q3U8E4|uniprotkb:B1AZS7|ensembl:ENSMUSP00000026328 intact:EBI-16091651|ensembl:ENSP00000369081 psi-mi:prdx4_mouse(display_long)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym)|uniprotkb:Prdx4(gene name)|psi-mi:Prdx4(display_short) psi-mi:q8nbs9-1(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name) psi-mi:"MI:0071"(molecular sieving) Kojima et al. (2014) pubmed:24462249|doi:10.1016/j.str.2013.12.013|imex:IM-22330 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16091681|imex:IM-22330-2|dip:DIP-195823E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_058044.1|refseq:NP_001300640.1|dip:DIP-34137N|ensembl:ENSMUSG00000025289(gene)|ensembl:ENSMUST00000026328(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:O08807|rcsb pdb:3VWU|rcsb pdb:3VWV|rcsb pdb:3W8J|rcsb pdb:3WGX|reactome:R-MMU-6798695 intact:EBI-2510815(isoform-parent)|ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:86EzEedrO6v5Z2dnSB2fSPaV2hc10090 rogid:bz5VVWMPFLTRKwph60UFASjsFN49606 rigid:SDDpZckQVkmUJFqEIamhWCa+BtU false sufficient binding region:244-263 sufficient binding region:190-298 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)