#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95136	uniprotkb:Q9JK11-1	intact:EBI-10634606|uniprotkb:Q86UN8|ensembl:ENSP00000496438	intact:EBI-919989	psi-mi:s1pr2_human(display_long)|uniprotkb:S1PR2(gene name)|psi-mi:S1PR2(display_short)|uniprotkb:EDG5(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091320|imex:IM-22345-1|dip:DIP-195860E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60682N|refseq:NP_004221.3|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1ZTI|reactome:R-HSA-418594|reactome:R-HSA-419408|ensembl:ENSG00000267534(gene)|ensembl:ENST00000646641(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)	intact:EBI-919972(rtn4_rat)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:ARaavcJykjiU7GQbZhgD1bnjNpI9606	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	rigid:86bx+BGHMSwhoR/7hssBFbnqSQQ	false	-	sufficient binding region:544-725	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O95136	uniprotkb:Q9JK11-1	intact:EBI-10634606|uniprotkb:Q86UN8|ensembl:ENSP00000496438	intact:EBI-919989	psi-mi:s1pr2_human(display_long)|uniprotkb:S1PR2(gene name)|psi-mi:S1PR2(display_short)|uniprotkb:EDG5(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091398|imex:IM-22345-3|dip:DIP-195860E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60682N|refseq:NP_004221.3|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1ZTI|reactome:R-HSA-418594|reactome:R-HSA-419408|ensembl:ENSG00000267534(gene)|ensembl:ENST00000646641(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008528"(G protein-coupled peptide receptor activity)	intact:EBI-919972(rtn4_rat)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ARaavcJykjiU7GQbZhgD1bnjNpI9606	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	rigid:86bx+BGHMSwhoR/7hssBFbnqSQQ	false	-	sufficient binding region:1-979	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52592	uniprotkb:Q9JK11-1	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	intact:EBI-919989	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091375|imex:IM-22345-2|dip:DIP-195862E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	intact:EBI-919972(rtn4_rat)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	rigid:0J3NzOyCM9MOYMEQTgjgQ5eY2Bs	false	-	sufficient binding region:544-725|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52592	uniprotkb:Q9JK11-1	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	intact:EBI-919989	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091476|imex:IM-22345-7|dip:DIP-195862E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	intact:EBI-919972(rtn4_rat)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	rigid:0J3NzOyCM9MOYMEQTgjgQ5eY2Bs	false	-	sufficient binding region:544-725|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52592	uniprotkb:Q9JK11-1	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	intact:EBI-919989	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:q9jk11-1(display_long)|uniprotkb:Nogo-A(isoform synonym)|uniprotkb:NI-220-250(isoform synonym)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Glut4 vesicle 20 kDa protein(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:"MI:1247"(microscale thermophoresis)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091451|imex:IM-22345-6|dip:DIP-195862E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	intact:EBI-919972(rtn4_rat)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rogid:CEWzvhKyKl/Cdz7MmociJDKwNPk10116	rigid:0J3NzOyCM9MOYMEQTgjgQ5eY2Bs	false	sufficient binding region:92-105|sufficient binding region:171-192|sufficient binding region:251-269	sufficient binding region:544-725	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99P72	uniprotkb:P52592	intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091434|imex:IM-22345-5|dip:DIP-195861E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rigid:VkHvHLxaejZeBA9JOtmB6f9L+Gg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62991	uniprotkb:P52592	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091417|imex:IM-22345-4|dip:DIP-195863E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rigid:Ey1tHPly3Cw0bDEFsrvMwt9YLyE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99P72	uniprotkb:P52592	intact:EBI-3869532|uniprotkb:Q8BHF5|uniprotkb:Q78NS1|uniprotkb:Q8BH78|uniprotkb:Q5DTK9|uniprotkb:Q7TNB7|uniprotkb:Q80W95|uniprotkb:Q8BGK7|uniprotkb:Q8BGM9|uniprotkb:Q8K290|uniprotkb:Q8K3G8|uniprotkb:Q9CTE3|ensembl:ENSMUSP00000099907	intact:EBI-16091339|ensembl:ENSMUSP00000053394|uniprotkb:Q8C3Q7|uniprotkb:Q9R236	psi-mi:rtn4_mouse(display_long)|uniprotkb:Rtn4(gene name)|psi-mi:Rtn4(display_short)|uniprotkb:Kiaa0886(gene name synonym)|uniprotkb:Nogo(gene name synonym)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)	psi-mi:s1pr2_mouse(display_long)|uniprotkb:S1pr2(gene name)|psi-mi:S1pr2(display_short)|uniprotkb:Edg5(gene name synonym)|uniprotkb:Gpcr13(gene name synonym)|uniprotkb:Lpb2(gene name synonym)|uniprotkb:Endothelial differentiation G-protein coupled receptor 5(gene name synonym)|uniprotkb:Lysophospholipid receptor B2(gene name synonym)|uniprotkb:Sphingosine 1-phosphate receptor Edg-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kempf et al. (2014)	pubmed:24453941|doi:10.1371/journal.pbio.1001763|imex:IM-22345	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16091499|imex:IM-22345-8|dip:DIP-195861E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077188.1|refseq:NP_918940.1|refseq:NP_918943.1|dip:DIP-41976N|ensembl:ENSMUSG00000020458(gene)|ensembl:ENSMUST00000102843(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051960"(regulation of nervous system development)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q99P72|rcsb pdb:2KO2|reactome:R-MMU-193634|refseq:NP_918941.1|refseq:NP_918942.1	go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0038036"(sphingosine-1-phosphate receptor activity)|ensembl:ENSMUSG00000043895(gene)|ensembl:ENSMUST00000054197(transcript)|go:"GO:0046847"(filopodium assembly)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR004061(Sphingosine 1-phosphate receptor)|interpro:IPR004063(EDG-5 sphingosine 1-phosphate receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-418594|reactome:R-MMU-419408|refseq:NP_034463.2|refseq:XP_006510082.1|dip:DIP-60681N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:+hmGWVeJPIbs6/SavXBsKK22Nqw10090	rogid:lmoNxuEvvFI4stCDI32hEoWB6NQ10090	rigid:VkHvHLxaejZeBA9JOtmB6f9L+Gg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)