#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13951 uniprotkb:P69723 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 intact:EBI-15528966|uniprotkb:P03401 psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:vif_hv1h2(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2014) pubmed:24418540|doi:10.1016/j.virol.2013.11.004|imex:IM-24803 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16090048|imex:IM-24803-1|dip:DIP-199748E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180585|reactome:R-HSA-180689|reactome:R-HSA-180910|dip:DIP-61318N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11706 rigid:Q8AHAbvsOo4TKzOBkKGupW2PgEs false - myc tag:c-c|mutation disrupting interaction strength:21-21|mutation disrupting interaction strength:89-89|mutation disrupting interaction strength:89-89,88-88|mutation decreasing interaction strength:38-38|mutation decreasing interaction strength:69-69 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15370-1 uniprotkb:P69723 intact:EBI-15581828|ensembl:ENSP00000386652 intact:EBI-15528966|uniprotkb:P03401 psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:vif_hv1h2(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2014) pubmed:24418540|doi:10.1016/j.virol.2013.11.004|imex:IM-24803 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16090083|imex:IM-24803-2|dip:DIP-199750E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180585|reactome:R-HSA-180689|reactome:R-HSA-180910|dip:DIP-61318N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11706 rigid:j5SXt3zMD+ocBzzOAAYygcdae60 false - myc tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q93034 uniprotkb:P69723 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15528966|uniprotkb:P03401 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1h2(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2014) pubmed:24418540|doi:10.1016/j.virol.2013.11.004|imex:IM-24803 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16090102|imex:IM-24803-3|dip:DIP-199749E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180585|reactome:R-HSA-180689|reactome:R-HSA-180910|dip:DIP-61318N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11706 rigid:SnY8NouoSy4js+p9some14HgJz4 false - myc tag:c-c|mutation disrupting interaction strength:21-21|mutation disrupting interaction strength:89-89|mutation disrupting interaction strength:89-89,88-88|mutation disrupting interaction strength:38-38 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)