#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12923 uniprotkb:Q13501 intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gump et al. (2014) pubmed:24316673|doi:10.1038/ncb2886|imex:IM-22403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16084892|imex:IM-22403-1|dip:DIP-196042E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 rigid:n3HycupgzQXptrzcg44PJa37RqQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q12923 uniprotkb:Q13501 intact:EBI-355227|uniprotkb:Q9UDA8|uniprotkb:Q15159|uniprotkb:Q15263|uniprotkb:Q15264|uniprotkb:Q15265|uniprotkb:Q15674|uniprotkb:Q16826|uniprotkb:Q8IWH7|uniprotkb:Q9NYN9|uniprotkb:B2RTR0|ensembl:ENSP00000407249 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:ptn13_human(display_long)|uniprotkb:PTPN13(gene name)|psi-mi:PTPN13(display_short)|uniprotkb:PNP1(gene name synonym)|uniprotkb:PTP1E(gene name synonym)|uniprotkb:PTPL1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase 1E(gene name synonym)|uniprotkb:PTP-BAS(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase PTPL1(gene name synonym)|uniprotkb:Fas-associated protein-tyrosine phosphatase 1(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Gump et al. (2014) pubmed:24316673|doi:10.1038/ncb2886|imex:IM-22403 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16084909|imex:IM-22403-2|dip:DIP-196042E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006255.1|refseq:NP_542414.1|refseq:NP_542415.1|refseq:NP_542416.1|ensembl:ENST00000316707|ensembl:ENSP00000322675|ensembl:ENSP00000407249|ensembl:ENST00000427191|ensembl:ENSP00000408368|ensembl:ENST00000436978|ensembl:ENSP00000394794|ensembl:ENST00000511467|ensembl:ENSP00000426626|dip:DIP-40449N|ensembl:ENSG00000163629(gene)|ensembl:ENST00000411767(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR011019(KIND)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012153(Protein-tyrosine phosphatase, non-receptor type-13)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029021|interpro:IPR029071|interpro:IPR035963|interpro:IPR036034|mint:Q12923|rcsb pdb:1D5G|rcsb pdb:1Q7X|go:"GO:0001933"(negative regulation of protein phosphorylation)|rcsb pdb:1WCH|rcsb pdb:2M0Z|rcsb pdb:2M10|rcsb pdb:3LNX|rcsb pdb:3LNY|rcsb pdb:3PDZ|rcsb pdb:5GLJ|reactome:R-HSA-1660499|reactome:R-HSA-9008059|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273 ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:PU9d6x+mLnjomT1yfPSVBg0i2Bk9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 rigid:n3HycupgzQXptrzcg44PJa37RqQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)