#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99836-1	uniprotkb:Q99836-1	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0071"(molecular sieving)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084416|imex:IM-24793-2|dip:DIP-199724E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:UBAjuE00JGBopnHuMyC24SYir3g	false	sufficient binding region:1-152	sufficient binding region:1-152	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P58753-2	uniprotkb:Q99836-1	intact:EBI-528654|ensembl:ENSP00000376445	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:p58753-2(display_long)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:MyD88 adapter-like protein(gene name synonym)	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0096"(pull down)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084390|imex:IM-24793-1|dip:DIP-63396E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-528644(tirap_human)|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392678(transcript)	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:gcFbrK23U/GvAm2QoMAqQYuo3RM9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:PDO/l7hP+3xT9GG/m/rqG8hvNUQ	false	sufficient binding region:75-235	sufficient binding region:148-296|mutation decreasing interaction strength:196-196|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9NWZ3	uniprotkb:Q99836-1	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084434|imex:IM-24793-3|dip:DIP-82398E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:4iC5GA0fYAwfUiLiCM2nyucIiaI	false	sufficient binding region:1-150|mutation decreasing interaction strength:12-12|mutation decreasing interaction strength:20-20	sufficient binding region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWZ3	uniprotkb:Q9NWZ3	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:"MI:0071"(molecular sieving)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084488|imex:IM-24793-5|dip:DIP-199725E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rigid:Tb/S3ASy/c1Din8ZCnH0+JoK1xo	false	sufficient binding region:1-150	sufficient binding region:1-150	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWZ3	uniprotkb:Q99836-1	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0071"(molecular sieving)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084461|imex:IM-24793-4|dip:DIP-82398E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:4iC5GA0fYAwfUiLiCM2nyucIiaI	false	sufficient binding region:1-150|mutation disrupting interaction strength:12-12|mutation decreasing interaction strength:20-20	sufficient binding region:1-152	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWZ3	uniprotkb:Q99836-1	intact:EBI-448378|uniprotkb:Q69FE1|uniprotkb:Q8TDF7|uniprotkb:Q9Y589|ensembl:ENSP00000446490|ensembl:ENSP00000479889	intact:EBI-15855480|ensembl:ENSP00000379625|ensembl:ENSP00000498360	psi-mi:irak4_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-64(gene name synonym)|uniprotkb:IRAK4(gene name)|psi-mi:IRAK4(display_short)	psi-mi:q99836-1(display_long)|uniprotkb:MYD88(gene name)|psi-mi:MYD88(display_short)	psi-mi:"MI:0071"(molecular sieving)	Yamamoto et al. (2014)	pubmed:24316379|doi:"https://doi.org/10.1016/j.molimm.2013.11.008"|imex:IM-24793	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16084506|imex:IM-24793-6|dip:DIP-82398E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107654.1|refseq:NP_001138728.1|refseq:NP_001138729.1|refseq:NP_001138730.1|refseq:NP_057207.2|refseq:XP_005269000.1|refseq:XP_005269001.1|refseq:XP_005269002.1|refseq:XP_005269004.1|refseq:XP_005269005.1|refseq:XP_005269006.1|refseq:XP_011536733.1|refseq:XP_011536734.1|refseq:XP_011536735.1|refseq:XP_006719501.1|refseq:XP_006719502.1|refseq:XP_016874879.1|refseq:XP_016874880.1|dip:DIP-31351N|rcsb pdb:5K75|rcsb pdb:5K76|rcsb pdb:5K7G|rcsb pdb:5K7I|rcsb pdb:5KX7|rcsb pdb:5KX8|rcsb pdb:5T1S|rcsb pdb:5T1T|rcsb pdb:5UIQ|rcsb pdb:5UIR|rcsb pdb:5UIS|rcsb pdb:5UIT|rcsb pdb:5UIU|rcsb pdb:5W84|rcsb pdb:5W85|rcsb pdb:6EG9|rcsb pdb:6EGA|rcsb pdb:6EGD|rcsb pdb:6EGE|rcsb pdb:6EGF|reactome:R-HSA-166058|rcsb pdb:6F3D|reactome:R-HSA-5603037|reactome:R-HSA-5603041|reactome:R-HSA-6811558|reactome:R-HSA-9020702|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975871|rcsb pdb:6F3E|rcsb pdb:6F3G|rcsb pdb:6F3I|rcsb pdb:6LXY|rcsb pdb:6MOM|rcsb pdb:6N8G|rcsb pdb:6O8U|rcsb pdb:6O94|rcsb pdb:6O95|rcsb pdb:6O9D|rcsb pdb:6RFI|rcsb pdb:6RFJ|rcsb pdb:6THW|rcsb pdb:6THX|rcsb pdb:6THZ|rcsb pdb:6TI8|rcsb pdb:6TIA|rcsb pdb:6UYA|rcsb pdb:6VQL|rcsb pdb:7C2V|rcsb pdb:7C2W|reactome:R-HSA-1257604|ensembl:ENSG00000198001(gene)|ensembl:ENST00000551736(transcript)|ensembl:ENST00000613694(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007254"(JNK cascade)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990266"(neutrophil migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017428(Interleukin-1 receptor-associated kinase 4)|interpro:IPR037970|mint:Q9NWZ3|rcsb pdb:2NRU|rcsb pdb:2NRY|rcsb pdb:2O8Y|rcsb pdb:2OIB|rcsb pdb:2OIC|rcsb pdb:2OID|rcsb pdb:3MOP|rcsb pdb:4RMZ|rcsb pdb:4U97|rcsb pdb:4U9A|rcsb pdb:4XS2|rcsb pdb:4Y73|rcsb pdb:4YO6|rcsb pdb:4YP8|rcsb pdb:4ZTL|rcsb pdb:4ZTM|rcsb pdb:4ZTN|rcsb pdb:5K72	intact:EBI-447677(isoform-parent)|ensembl:ENSG00000172936(gene)|ensembl:ENST00000396334(transcript)|ensembl:ENST00000650905(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:/m8S9iEd9yAaaA7asytw8VKbd5s9606	rogid:B920s5F0eUql/jtwlByyhI7ojGI9606	rigid:4iC5GA0fYAwfUiLiCM2nyucIiaI	false	sufficient binding region:1-150	sufficient binding region:1-152|mutation disrupting interaction strength:98-98	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)