#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-4399559 uniprotkb:Q96SW2-2 dip:DIP-24261N intact:EBI-10693561|ensembl:ENSP00000412499 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0096"(pull down) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083528|imex:IM-24257-1|dip:DIP-198811E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) psi-mi:"MI:0465"(dip) no-uniprot-update: isoform-comment:No experimental confirmation available. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rigid:7ujiJRJ/UNGwFcivqzdSsFEXoxw false his tag:0-0 flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) intact:EBI-4399559 uniprotkb:Q13422-7 dip:DIP-24261N intact:EBI-11522367|ensembl:ENSP00000352123|ensembl:ENSP00000413025 psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:q13422-7(display_long)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym) psi-mi:"MI:0096"(pull down) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083528|imex:IM-24257-1|dip:DIP-198811E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 intact:EBI-745305(isoform-parent)|ensembl:ENSG00000185811(gene)|ensembl:ENST00000359197(transcript)|ensembl:ENST00000439701(transcript)|uniprotkb:Q13422-7(isoform-parent) psi-mi:"MI:0465"(dip) no-uniprot-update: - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rogid:ou/ovXYoMneBNVp4pj38VxenfyY9606 rigid:7ujiJRJ/UNGwFcivqzdSsFEXoxw false his tag:0-0 v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13422-7 uniprotkb:Q96SW2 intact:EBI-11522367|ensembl:ENSP00000352123|ensembl:ENSP00000413025 intact:EBI-2510250|ensembl:ENSP00000231948|uniprotkb:B2R6H4|uniprotkb:C9IZA9|uniprotkb:C9JAH6|uniprotkb:Q6NVZ0|uniprotkb:Q6AI62|uniprotkb:Q9UHW4 psi-mi:q13422-7(display_long)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym) psi-mi:crbn_human(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083580|imex:IM-24257-3|dip:DIP-198810E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-745305(isoform-parent)|ensembl:ENSG00000185811(gene)|ensembl:ENST00000359197(transcript)|ensembl:ENST00000439701(transcript)|uniprotkb:Q13422-7(isoform-parent) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1902607"(negative regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR004910(Yippee-like protein)|interpro:IPR034750|mint:Q96SW2|rcsb pdb:4M91|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5V3O|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|interpro:IPR015947(PUA-like)|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7BQU|rcsb pdb:7BQV|rcsb pdb:7LPS|reactome:R-HSA-9679191|ensembl:ENSG00000113851(gene)|ensembl:ENST00000231948(transcript)|refseq:NP_057386.2|refseq:NP_001166953.1|dip:DIP-53521N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ou/ovXYoMneBNVp4pj38VxenfyY9606 rogid:R1sZch07ti/kUKYBByte0xAoCMo9606 rigid:z+t8oS2Xj8+IubpJpxX/QMx5DiU false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q9UKT9 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-747204|uniprotkb:Q8WWQ9|uniprotkb:Q8WWR0|uniprotkb:Q8WWR1|uniprotkb:Q8WWR2|uniprotkb:Q8WWR3|uniprotkb:Q8N574|uniprotkb:B4DVV5|uniprotkb:Q69BL6|uniprotkb:Q69BL7|uniprotkb:Q69BL8|uniprotkb:Q69BL9|uniprotkb:Q69BM0|uniprotkb:Q69BM1|uniprotkb:Q69BM2|uniprotkb:Q69BM3|uniprotkb:Q69BM5|ensembl:ENSP00000344544 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ikzf3_human(display_long)|uniprotkb:ZNFN1A3(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 3(gene name synonym)|uniprotkb:IKZF3(gene name)|psi-mi:IKZF3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083556|imex:IM-24257-2|dip:DIP-198816E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001271443.1|refseq:NP_001271444.1|refseq:NP_036613.2|refseq:NP_899051.1|refseq:NP_899052.1|refseq:NP_899053.1|refseq:NP_899054.1|refseq:NP_899055.1|refseq:NP_001271445.1|refseq:NP_001244337.1|refseq:NP_001244338.1|refseq:NP_001244339.1|refseq:NP_001244340.1|refseq:NP_001244341.1|refseq:NP_001244342.1|refseq:NP_001244343.1|ensembl:ENSG00000161405(gene)|ensembl:ENST00000346872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009617"(response to bacterium)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0046872"(metal ion binding)|dip:DIP-56975N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:2Kp6LefSLfK5VIiE6DmQusFIfMY9606 rigid:PCah5Zlk3cjzC8wDODW15STsxzc false flag tag:?-? ha tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q16531 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083556|imex:IM-24257-2|dip:DIP-198816E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:PCah5Zlk3cjzC8wDODW15STsxzc false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13422-7 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-11522367|ensembl:ENSP00000352123|ensembl:ENSP00000413025 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:q13422-7(display_long)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083670|imex:IM-24257-7|dip:DIP-198810E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) intact:EBI-745305(isoform-parent)|ensembl:ENSG00000185811(gene)|ensembl:ENST00000359197(transcript)|ensembl:ENST00000439701(transcript)|uniprotkb:Q13422-7(isoform-parent) psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:ou/ovXYoMneBNVp4pj38VxenfyY9606 rigid:ZwAEeN9jqenm/W2lggr9vDHEpMc false mutation disrupting interaction strength:385-385,383-383|ha tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q9UKT9 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-747204|uniprotkb:Q8WWQ9|uniprotkb:Q8WWR0|uniprotkb:Q8WWR1|uniprotkb:Q8WWR2|uniprotkb:Q8WWR3|uniprotkb:Q8N574|uniprotkb:B4DVV5|uniprotkb:Q69BL6|uniprotkb:Q69BL7|uniprotkb:Q69BL8|uniprotkb:Q69BL9|uniprotkb:Q69BM0|uniprotkb:Q69BM1|uniprotkb:Q69BM2|uniprotkb:Q69BM3|uniprotkb:Q69BM5|ensembl:ENSP00000344544 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ikzf3_human(display_long)|uniprotkb:ZNFN1A3(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 3(gene name synonym)|uniprotkb:IKZF3(gene name)|psi-mi:IKZF3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083699|imex:IM-24257-8|dip:DIP-198813E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001271443.1|refseq:NP_001271444.1|refseq:NP_036613.2|refseq:NP_899051.1|refseq:NP_899052.1|refseq:NP_899053.1|refseq:NP_899054.1|refseq:NP_899055.1|refseq:NP_001271445.1|refseq:NP_001244337.1|refseq:NP_001244338.1|refseq:NP_001244339.1|refseq:NP_001244340.1|refseq:NP_001244341.1|refseq:NP_001244342.1|refseq:NP_001244343.1|ensembl:ENSG00000161405(gene)|ensembl:ENST00000346872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009617"(response to bacterium)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0046872"(metal ion binding)|dip:DIP-56975N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:2Kp6LefSLfK5VIiE6DmQusFIfMY9606 rigid:AsSaVx+IwApI8ijxT4JrheV+uR8 false flag tag:?-? ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13619 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083699|imex:IM-24257-8|dip:DIP-198813E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 rigid:AsSaVx+IwApI8ijxT4JrheV+uR8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q16531 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083699|imex:IM-24257-8|dip:DIP-198813E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:AsSaVx+IwApI8ijxT4JrheV+uR8 false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q16531 uniprotkb:Q96SW2-2 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 intact:EBI-10693561|ensembl:ENSP00000412499 psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083724|imex:IM-24257-9|dip:DIP-198815E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) psi-mi:"MI:0465"(dip) - isoform-comment:No experimental confirmation available. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rigid:MnzkVE3tABbQgPtmlCdXRLWvxn4 false ha tag:n-n flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13619 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083648|imex:IM-24257-6|dip:DIP-198814E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 rigid:+pUnUnfTSF9ieL8MWbDXXM3hE5Y false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q16531 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083648|imex:IM-24257-6|dip:DIP-198814E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:+pUnUnfTSF9ieL8MWbDXXM3hE5Y false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13422-1 uniprotkb:Q96SW2 intact:EBI-16083747|ensembl:ENSP00000331614 intact:EBI-2510250|ensembl:ENSP00000231948|uniprotkb:B2R6H4|uniprotkb:C9IZA9|uniprotkb:C9JAH6|uniprotkb:Q6NVZ0|uniprotkb:Q6AI62|uniprotkb:Q9UHW4 psi-mi:q13422-1(display_long)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym) psi-mi:crbn_human(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083758|imex:IM-24257-10|dip:DIP-198810E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185811(gene)|ensembl:ENST00000331340(transcript)|intact:EBI-745305(isoform-parent) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1902607"(negative regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR004910(Yippee-like protein)|interpro:IPR034750|mint:Q96SW2|rcsb pdb:4M91|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5V3O|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|interpro:IPR015947(PUA-like)|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7BQU|rcsb pdb:7BQV|rcsb pdb:7LPS|reactome:R-HSA-9679191|ensembl:ENSG00000113851(gene)|ensembl:ENST00000231948(transcript)|refseq:NP_057386.2|refseq:NP_001166953.1|dip:DIP-53521N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:RizH0uz3DbSyFFvmlIhisx+S+DI9606 rogid:R1sZch07ti/kUKYBByte0xAoCMo9606 rigid:Ae6DJm33KZJV2Vl6m/5VEbDEBVM false mutation decreasing interaction strength:146-146|flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q9UKT9 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-747204|uniprotkb:Q8WWQ9|uniprotkb:Q8WWR0|uniprotkb:Q8WWR1|uniprotkb:Q8WWR2|uniprotkb:Q8WWR3|uniprotkb:Q8N574|uniprotkb:B4DVV5|uniprotkb:Q69BL6|uniprotkb:Q69BL7|uniprotkb:Q69BL8|uniprotkb:Q69BL9|uniprotkb:Q69BM0|uniprotkb:Q69BM1|uniprotkb:Q69BM2|uniprotkb:Q69BM3|uniprotkb:Q69BM5|ensembl:ENSP00000344544 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ikzf3_human(display_long)|uniprotkb:ZNFN1A3(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 3(gene name synonym)|uniprotkb:IKZF3(gene name)|psi-mi:IKZF3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083601|imex:IM-24257-4|dip:DIP-198817E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001271443.1|refseq:NP_001271444.1|refseq:NP_036613.2|refseq:NP_899051.1|refseq:NP_899052.1|refseq:NP_899053.1|refseq:NP_899054.1|refseq:NP_899055.1|refseq:NP_001271445.1|refseq:NP_001244337.1|refseq:NP_001244338.1|refseq:NP_001244339.1|refseq:NP_001244340.1|refseq:NP_001244341.1|refseq:NP_001244342.1|refseq:NP_001244343.1|ensembl:ENSG00000161405(gene)|ensembl:ENST00000346872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009617"(response to bacterium)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0046872"(metal ion binding)|dip:DIP-56975N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:2Kp6LefSLfK5VIiE6DmQusFIfMY9606 rigid:f4lenpfAtqOmfSscvg3DoltI+dg false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13422 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-745305|uniprotkb:O00598|uniprotkb:Q8WVA3|uniprotkb:Q53XL2|uniprotkb:B4E0Z1|uniprotkb:A4D260|uniprotkb:D3DVM5|intact:EBI-28969803|ensembl:ENSP00000331614|uniprotkb:Q69BM4 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ikzf1_human(display_long)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083601|imex:IM-24257-4|dip:DIP-198817E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001207694.1|refseq:NP_001207696.1|refseq:NP_001207697.1|refseq:NP_001207699.1|refseq:NP_001207700.1|refseq:NP_006051.1|refseq:NP_001278766.1|refseq:NP_001278767.1|refseq:NP_001278768.1|refseq:NP_001278769.1|refseq:NP_001278770.1|refseq:NP_001278771.1|refseq:NP_001278772.1|refseq:NP_001278773.1|ensembl:ENSP00000331614|ensembl:ENST00000343574|ensembl:ENSP00000342750|ensembl:ENST00000349824|ensembl:ENSP00000342485|ensembl:ENST00000357364|ensembl:ENSP00000349928|ensembl:ENST00000359197|ensembl:ENSP00000352123|ensembl:ENST00000438033|ensembl:ENSP00000396554|ensembl:ENST00000439701|ensembl:ENSP00000413025|ensembl:ENST00000331340(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007498"(mesoderm development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q13422|rcsb pdb:6H0F|reactome:R-HSA-9013508|ensembl:ENSG00000185811(gene)|refseq:XP_011513370.1|refseq:XP_011513371.1|refseq:XP_011513377.1|refseq:XP_011513378.1|refseq:XP_016867157.1|dip:DIP-41110N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:RizH0uz3DbSyFFvmlIhisx+S+DI9606 rigid:f4lenpfAtqOmfSscvg3DoltI+dg false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q16531 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083601|imex:IM-24257-4|dip:DIP-198817E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:f4lenpfAtqOmfSscvg3DoltI+dg false flag tag:?-? ha tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT9 uniprotkb:Q96SW2 intact:EBI-747204|uniprotkb:Q8WWQ9|uniprotkb:Q8WWR0|uniprotkb:Q8WWR1|uniprotkb:Q8WWR2|uniprotkb:Q8WWR3|uniprotkb:Q8N574|uniprotkb:B4DVV5|uniprotkb:Q69BL6|uniprotkb:Q69BL7|uniprotkb:Q69BL8|uniprotkb:Q69BL9|uniprotkb:Q69BM0|uniprotkb:Q69BM1|uniprotkb:Q69BM2|uniprotkb:Q69BM3|uniprotkb:Q69BM5|ensembl:ENSP00000344544 intact:EBI-2510250|ensembl:ENSP00000231948|uniprotkb:B2R6H4|uniprotkb:C9IZA9|uniprotkb:C9JAH6|uniprotkb:Q6NVZ0|uniprotkb:Q6AI62|uniprotkb:Q9UHW4 psi-mi:ikzf3_human(display_long)|uniprotkb:ZNFN1A3(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 3(gene name synonym)|uniprotkb:IKZF3(gene name)|psi-mi:IKZF3(display_short) psi-mi:crbn_human(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083626|imex:IM-24257-5|dip:DIP-198818E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271443.1|refseq:NP_001271444.1|refseq:NP_036613.2|refseq:NP_899051.1|refseq:NP_899052.1|refseq:NP_899053.1|refseq:NP_899054.1|refseq:NP_899055.1|refseq:NP_001271445.1|refseq:NP_001244337.1|refseq:NP_001244338.1|refseq:NP_001244339.1|refseq:NP_001244340.1|refseq:NP_001244341.1|refseq:NP_001244342.1|refseq:NP_001244343.1|ensembl:ENSG00000161405(gene)|ensembl:ENST00000346872(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0009617"(response to bacterium)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0046872"(metal ion binding)|dip:DIP-56975N go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1902607"(negative regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR004910(Yippee-like protein)|interpro:IPR034750|mint:Q96SW2|rcsb pdb:4M91|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5V3O|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|interpro:IPR015947(PUA-like)|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7BQU|rcsb pdb:7BQV|rcsb pdb:7LPS|reactome:R-HSA-9679191|ensembl:ENSG00000113851(gene)|ensembl:ENST00000231948(transcript)|refseq:NP_057386.2|refseq:NP_001166953.1|dip:DIP-53521N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:2Kp6LefSLfK5VIiE6DmQusFIfMY9606 rogid:R1sZch07ti/kUKYBByte0xAoCMo9606 rigid:jvrOmPVfydraDOrZuI8CK78Js/s false flag tag:c-c|mutation decreasing interaction strength:147-147 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13619 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083782|imex:IM-24257-11|dip:DIP-198812E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 rigid:Trz3QnaZwNwxtXlSxBupYM6stOw false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q16531 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083782|imex:IM-24257-11|dip:DIP-198812E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:Trz3QnaZwNwxtXlSxBupYM6stOw false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SW2-2 uniprotkb:Q13422-7 intact:EBI-10693561|ensembl:ENSP00000412499 intact:EBI-11522367|ensembl:ENSP00000352123|ensembl:ENSP00000413025 psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:q13422-7(display_long)|uniprotkb:IKZF1(gene name)|psi-mi:IKZF1(display_short)|uniprotkb:IK1(gene name synonym)|uniprotkb:IKAROS(gene name synonym)|uniprotkb:Ikaros family zinc finger protein 1(gene name synonym)|uniprotkb:LYF1(gene name synonym)|uniprotkb:Lymphoid transcription factor LyF-1(gene name synonym)|uniprotkb:ZNFN1A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16083782|imex:IM-24257-11|dip:DIP-198812E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) intact:EBI-745305(isoform-parent)|ensembl:ENSG00000185811(gene)|ensembl:ENST00000359197(transcript)|ensembl:ENST00000439701(transcript)|uniprotkb:Q13422-7(isoform-parent) psi-mi:"MI:0465"(dip) isoform-comment:No experimental confirmation available. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rogid:ou/ovXYoMneBNVp4pj38VxenfyY9606 rigid:Trz3QnaZwNwxtXlSxBupYM6stOw false flag tag:?-? ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q16531 uniprotkb:Q96SW2-2 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 intact:EBI-10693561|ensembl:ENSP00000412499 psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:q96sw2-2(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lu et al. (2014) pubmed:24292623|doi:10.1126/science.1244917|imex:IM-24257 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16083809|imex:IM-24257-12|dip:DIP-198815E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N ensembl:ENSG00000113851(gene)|ensembl:ENST00000432408(transcript)|intact:EBI-2510250(isoform-parent)|uniprotkb:Q96SW2-2(isoform-parent) psi-mi:"MI:0465"(dip) - isoform-comment:No experimental confirmation available. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rogid:gWwrgG/aX24CQNiDPMV0dxKsmNE9606 rigid:MnzkVE3tABbQgPtmlCdXRLWvxn4 false - flag tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)