#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P97447-2 uniprotkb:P31266 intact:EBI-16082627 intact:EBI-1392666|uniprotkb:Q80UN8|uniprotkb:Q8C4Z3|ensembl:ENSMUSP00000040694 psi-mi:p97447-2(display_long)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)|uniprotkb:KyoT2(isoform synonym)|uniprotkb:KyoT(gene name synonym) psi-mi:suh_mouse(display_long)|uniprotkb:Rbpj(gene name)|psi-mi:Rbpj(display_short)|uniprotkb:Igkjrb1(gene name synonym)|uniprotkb:Igkrsbp(gene name synonym)|uniprotkb:Rbpsuh(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Collins et al. (2014) pubmed:24290140|doi:10.1016/j.str.2013.10.010|imex:IM-22316 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16082636|imex:IM-22316-1|dip:DIP-195799E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643780(isoform-parent) refseq:NP_001074396.1|refseq:NP_033061.3|dip:DIP-171N|ensembl:ENSMUSG00000039191(gene)|ensembl:ENSMUST00000037618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001947"(heart looping)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:3BRG|rcsb pdb:3IAG|rcsb pdb:4J2X|rcsb pdb:5EG6|rcsb pdb:6DKS|rcsb pdb:6WQU|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-8941856 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LwyzJUvjsBiLxjaZgp+hXJmtxXY10090 rogid:6e2XZZX+zWA0UexPo1D0+3Hv08Y10090 rigid:YgTY0neU2w5Tkb+gDGK67EeovL8 false sufficient binding region:168-194 sufficient binding region:53-474 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97447-2 uniprotkb:P31266 intact:EBI-16082627 intact:EBI-1392666|uniprotkb:Q80UN8|uniprotkb:Q8C4Z3|ensembl:ENSMUSP00000040694 psi-mi:p97447-2(display_long)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)|uniprotkb:KyoT2(isoform synonym)|uniprotkb:KyoT(gene name synonym) psi-mi:suh_mouse(display_long)|uniprotkb:Rbpj(gene name)|psi-mi:Rbpj(display_short)|uniprotkb:Igkjrb1(gene name synonym)|uniprotkb:Igkrsbp(gene name synonym)|uniprotkb:Rbpsuh(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Collins et al. (2014) pubmed:24290140|doi:10.1016/j.str.2013.10.010|imex:IM-22316 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16082682|imex:IM-22316-3|dip:DIP-195799E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643780(isoform-parent) refseq:NP_001074396.1|refseq:NP_033061.3|dip:DIP-171N|ensembl:ENSMUSG00000039191(gene)|ensembl:ENSMUST00000037618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001947"(heart looping)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:3BRG|rcsb pdb:3IAG|rcsb pdb:4J2X|rcsb pdb:5EG6|rcsb pdb:6DKS|rcsb pdb:6WQU|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-8941856 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LwyzJUvjsBiLxjaZgp+hXJmtxXY10090 rogid:6e2XZZX+zWA0UexPo1D0+3Hv08Y10090 rigid:YgTY0neU2w5Tkb+gDGK67EeovL8 false sufficient binding region:168-194 sufficient binding region:53-474|mutation decreasing interaction strength:261-261|mutation decreasing interaction strength:284-284 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97447-2 uniprotkb:P31266 intact:EBI-16082627 intact:EBI-1392666|uniprotkb:Q80UN8|uniprotkb:Q8C4Z3|ensembl:ENSMUSP00000040694 psi-mi:p97447-2(display_long)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)|uniprotkb:KyoT2(isoform synonym)|uniprotkb:KyoT(gene name synonym) psi-mi:suh_mouse(display_long)|uniprotkb:Rbpj(gene name)|psi-mi:Rbpj(display_short)|uniprotkb:Igkjrb1(gene name synonym)|uniprotkb:Igkrsbp(gene name synonym)|uniprotkb:Rbpsuh(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Collins et al. (2014) pubmed:24290140|doi:10.1016/j.str.2013.10.010|imex:IM-22316 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16082657|imex:IM-22316-2|dip:DIP-195799E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643780(isoform-parent) refseq:NP_001074396.1|refseq:NP_033061.3|dip:DIP-171N|ensembl:ENSMUSG00000039191(gene)|ensembl:ENSMUST00000037618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001947"(heart looping)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:3BRG|rcsb pdb:3IAG|rcsb pdb:4J2X|rcsb pdb:5EG6|rcsb pdb:6DKS|rcsb pdb:6WQU|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-8941856 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LwyzJUvjsBiLxjaZgp+hXJmtxXY10090 rogid:6e2XZZX+zWA0UexPo1D0+3Hv08Y10090 rigid:YgTY0neU2w5Tkb+gDGK67EeovL8 false sufficient binding region:168-184|mutation disrupting interaction strength:176-176,175-175 sufficient binding region:53-474 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97447-2 uniprotkb:P31266 intact:EBI-16082627 intact:EBI-1392666|uniprotkb:Q80UN8|uniprotkb:Q8C4Z3|ensembl:ENSMUSP00000040694 psi-mi:p97447-2(display_long)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)|uniprotkb:KyoT2(isoform synonym)|uniprotkb:KyoT(gene name synonym) psi-mi:suh_mouse(display_long)|uniprotkb:Rbpj(gene name)|psi-mi:Rbpj(display_short)|uniprotkb:Igkjrb1(gene name synonym)|uniprotkb:Igkrsbp(gene name synonym)|uniprotkb:Rbpsuh(gene name synonym)|uniprotkb:J kappa-recombination signal-binding protein(gene name synonym)|uniprotkb:RBP-J kappa(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Collins et al. (2014) pubmed:24290140|doi:10.1016/j.str.2013.10.010|imex:IM-22316 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16082709|imex:IM-22316-4|dip:DIP-195799E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643780(isoform-parent) refseq:NP_001074396.1|refseq:NP_033061.3|dip:DIP-171N|ensembl:ENSMUSG00000039191(gene)|ensembl:ENSMUST00000037618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001756"(somitogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001947"(heart looping)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035481"(positive regulation of Notch signaling pathway involved in heart induction)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048505"(regulation of timing of cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060486"(club cell differentiation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060844"(arterial endothelial cell fate commitment)|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0097101"(blood vessel endothelial cell fate specification)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901186"(positive regulation of ERBB signaling pathway)|go:"GO:1901189"(positive regulation of ephrin receptor signaling pathway)|go:"GO:1901297"(positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:2000138"(positive regulation of cell proliferation involved in heart morphogenesis)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015350(Beta-trefoil)|interpro:IPR015351(LAG1, DNA binding)|interpro:IPR036358|interpro:IPR037095|interpro:IPR038007|interpro:IPR040159|rcsb pdb:3BRG|rcsb pdb:3IAG|rcsb pdb:4J2X|rcsb pdb:5EG6|rcsb pdb:6DKS|rcsb pdb:6WQU|reactome:R-MMU-2122947|reactome:R-MMU-350054|reactome:R-MMU-8941856 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:LwyzJUvjsBiLxjaZgp+hXJmtxXY10090 rogid:6e2XZZX+zWA0UexPo1D0+3Hv08Y10090 rigid:YgTY0neU2w5Tkb+gDGK67EeovL8 false sufficient binding region:171-180 sufficient binding region:53-474 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)