#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13351 intact:EBI-4399559 intact:EBI-8284732|uniprotkb:Q6PIJ5|intact:MINT-1891495|uniprotkb:Q92899|ensembl:ENSP00000264834 dip:DIP-24261N psi-mi:klf1_human(display_long)|uniprotkb:KLF1(gene name)|psi-mi:KLF1(display_short)|uniprotkb:EKLF(gene name synonym)|uniprotkb:Erythroid krueppel-like transcription factor(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Raiola et al. (2013) pubmed:24139988|doi:10.1016/j.str.2013.08.027|imex:IM-21918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16079186|imex:IM-21918-1|dip:DIP-74190E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006554.1|dip:DIP-43776N|ensembl:ENSG00000105610(gene)|ensembl:ENST00000264834(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:1901653"(cellular response to peptide)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR031784|interpro:IPR031785|interpro:IPR031786|interpro:IPR036236|rcsb pdb:2L2I|rcsb pdb:2MBH|rcsb pdb:2N23 uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) comment:mint|function:Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/15 rogid:73OSHhKpaQ3g+e/bj60x3U7Jmz89606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:pkl5FdAoUs0poYPucwUtBR3Glnc false sufficient binding region:1-40 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13351 intact:EBI-4399559 intact:EBI-8284732|uniprotkb:Q6PIJ5|intact:MINT-1891495|uniprotkb:Q92899|ensembl:ENSP00000264834 dip:DIP-24261N psi-mi:klf1_human(display_long)|uniprotkb:KLF1(gene name)|psi-mi:KLF1(display_short)|uniprotkb:EKLF(gene name synonym)|uniprotkb:Erythroid krueppel-like transcription factor(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Raiola et al. (2013) pubmed:24139988|doi:10.1016/j.str.2013.08.027|imex:IM-21918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16079224|imex:IM-21918-3|dip:DIP-74190E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006554.1|dip:DIP-43776N|ensembl:ENSG00000105610(gene)|ensembl:ENST00000264834(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:1901653"(cellular response to peptide)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR031784|interpro:IPR031785|interpro:IPR031786|interpro:IPR036236|rcsb pdb:2L2I|rcsb pdb:2MBH|rcsb pdb:2N23 uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) comment:mint|function:Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/15 rogid:73OSHhKpaQ3g+e/bj60x3U7Jmz89606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:pkl5FdAoUs0poYPucwUtBR3Glnc false sufficient binding region:1-40|sufficient binding region:50-90 mutation disrupting interaction strength:44-44 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 intact:EBI-4399559 intact:EBI-948328|ensembl:ENSP00000261646 dip:DIP-24261N psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Raiola et al. (2013) pubmed:24139988|doi:10.1016/j.str.2013.08.027|imex:IM-21918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16079205|imex:IM-21918-2|dip:DIP-192488E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) - no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/15 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:qGJVIiGzJ0C+q7wkuYnzO63howU false sufficient binding region:1-50 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13351 intact:EBI-4399559 intact:EBI-8284732|uniprotkb:Q6PIJ5|intact:MINT-1891495|uniprotkb:Q92899|ensembl:ENSP00000264834 dip:DIP-24261N psi-mi:klf1_human(display_long)|uniprotkb:KLF1(gene name)|psi-mi:KLF1(display_short)|uniprotkb:EKLF(gene name synonym)|uniprotkb:Erythroid krueppel-like transcription factor(gene name synonym) psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long) psi-mi:"MI:0077"(nuclear magnetic resonance) Raiola et al. (2013) pubmed:24139988|doi:10.1016/j.str.2013.08.027|imex:IM-21918 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16079248|imex:IM-21918-4|dip:DIP-74190E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006554.1|dip:DIP-43776N|ensembl:ENSG00000105610(gene)|ensembl:ENST00000264834(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:1901653"(cellular response to peptide)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR031784|interpro:IPR031785|interpro:IPR031786|interpro:IPR036236|rcsb pdb:2L2I|rcsb pdb:2MBH|rcsb pdb:2N23 uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2 psi-mi:"MI:0465"(dip) comment:mint|function:Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development no-uniprot-update: full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/15 rogid:73OSHhKpaQ3g+e/bj60x3U7Jmz89606 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606 rigid:pkl5FdAoUs0poYPucwUtBR3Glnc false sufficient binding region:1-40|sufficient binding region:50-90|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:28-28|mutation disrupting interaction strength:31-31 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)