#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17427	uniprotkb:O08839	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	intact:EBI-80095	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:bin1_rat(display_long)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amph2(gene name synonym)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078815|imex:IM-21954-1|dip:DIP-192593E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005768"(endosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|rcsb pdb:1BB9|reactome:R-RNO-8856828|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|rgd:621786|refseq:NP_446411.1|mint:O08839|dip:DIP-30979N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rogid:xqcXQWo+FXHjCGGI0Q9agaz9LMk10116	rigid:D30Memzel8BOJ0lwVk1HmfE/ABg	false	sufficient binding region:695-938|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17427	uniprotkb:O08838	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	intact:EBI-80080	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:amph_rat(display_long)|uniprotkb:Amph(gene name)|psi-mi:Amph(display_short)|uniprotkb:Amph1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078815|imex:IM-21954-1|dip:DIP-192593E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|rcsb pdb:2VJ0|rcsb pdb:5M5T|reactome:R-RNO-8856828|rgd:620274|refseq:NP_071553.1|mint:O08838|dip:DIP-30977N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rogid:wTANhsy4BxCZYbSIhwlrr+m9Tt810116	rigid:D30Memzel8BOJ0lwVk1HmfE/ABg	false	sufficient binding region:695-938|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9CR95	uniprotkb:O08839	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-80095	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:bin1_rat(display_long)|uniprotkb:Bin1(gene name)|psi-mi:Bin1(display_short)|uniprotkb:Amph2(gene name synonym)|uniprotkb:Amphl(gene name synonym)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078837|imex:IM-21954-2|dip:DIP-74736E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005768"(endosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0043196"(varicosity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048156"(tau protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060987"(lipid tube)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|rcsb pdb:1BB9|reactome:R-RNO-8856828|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|rgd:621786|refseq:NP_446411.1|mint:O08839|dip:DIP-30979N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:xqcXQWo+FXHjCGGI0Q9agaz9LMk10116	rigid:KacOaEevugConr7OXVcDgoYDE7o	false	sufficient binding region:1-133|mutation disrupting interaction strength:95-95|mutation disrupting interaction strength:102-102|mutation disrupting interaction strength:102-102|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9CR95	uniprotkb:O08838	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-80080	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:amph_rat(display_long)|uniprotkb:Amph(gene name)|psi-mi:Amph(display_short)|uniprotkb:Amph1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078837|imex:IM-21954-2|dip:DIP-74736E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003017(Amphiphysin, isoform 1)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035470|interpro:IPR036028|rcsb pdb:2VJ0|rcsb pdb:5M5T|reactome:R-RNO-8856828|rgd:620274|refseq:NP_071553.1|mint:O08838|dip:DIP-30977N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:wTANhsy4BxCZYbSIhwlrr+m9Tt810116	rigid:KacOaEevugConr7OXVcDgoYDE7o	false	sufficient binding region:1-133|mutation disrupting interaction strength:95-95|mutation disrupting interaction strength:102-102|mutation disrupting interaction strength:102-102|glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9CR95	uniprotkb:Q8K285	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-16078916|ensembl:ENSMUSP00000091151|ensembl:ENSMUSP00000117606|uniprotkb:D3Z3Q5	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:fcho1_mouse(display_long)|uniprotkb:Fcho1(gene name)|psi-mi:Fcho1(display_short)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078947|imex:IM-21954-5|dip:DIP-192595E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	ensembl:ENSMUSG00000070000(gene)|ensembl:ENSMUST00000093444(transcript)|ensembl:ENSMUST00000146100(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030121|interpro:IPR031160|interpro:IPR042735|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_082991.3|refseq:XP_006509828.1|refseq:XP_006509829.1|refseq:XP_006509830.1|dip:DIP-60611N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:4m2nv9xHV8fOMoMKQh/lb4df4l410090	rigid:X3lSGEyEvUCBJK4pcthRJX3iCTE	false	glutathione s tranferase tag:n-n|sufficient binding region:1-133	flag tag:n-n|sufficient binding region:1-610	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9CR95	uniprotkb:P63010	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078972|imex:IM-21954-6|dip:DIP-192592E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	rigid:kvlKh5bRHCWjy9vI45/KBBvoxpE	false	sufficient binding region:1-133	sufficient binding region:622-641	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9CR95	uniprotkb:P17427	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078993|imex:IM-21954-7|dip:DIP-192590E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	rigid:GKNCpDU5rvaaq4z+eLP355Zkbuo	false	flag tag:n-n	sufficient binding region:695-938|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P69682	uniprotkb:P63010	intact:EBI-7592718|intact:MINT-5260811|uniprotkb:Q4QR67|ensembl:ENSRNOP00000013272	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:necp1_rat(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078895|imex:IM-21954-4|dip:DIP-192591E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025090.1|rgd:1306053|ensembl:ENSRNOG00000009236(gene)|ensembl:ENSRNOT00000013272(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:P69682|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|dip:DIP-44064N	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KwuJp3lG7BL4q4Fzy7YtThmdCso10116	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	rigid:Gb3iDjKZMZBi0tgU6z2zNmEhzrc	false	-	sufficient binding region:592-668|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9CR95	uniprotkb:P63010	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16078868|imex:IM-21954-3|dip:DIP-192592E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606	rigid:kvlKh5bRHCWjy9vI45/KBBvoxpE	false	sufficient binding region:1-133|glutathione s tranferase tag:n-n	sufficient binding region:1-640|sufficient binding region:592-937|flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9CR95	uniprotkb:Q0JRZ9-1	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-15640469|ensembl:ENSP00000393776	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:q0jrz9-1(display_long)|uniprotkb:FCHO2(gene name)|psi-mi:FCHO2(display_short)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16079016|imex:IM-21954-8|dip:DIP-192594E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	intact:EBI-2609756(isoform-parent)|ensembl:ENSG00000157107(gene)|ensembl:ENST00000430046(transcript)	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:JYPt0L04ZvoacrpUFy49uFWxD489606	rigid:w9BDksdYKIkoulfF5lC5892qWBI	false	glutathione s tranferase tag:n-n|sufficient binding region:1-133|mutation decreasing interaction strength:95-95	mcherry fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9CR95	uniprotkb:Q8K285	intact:EBI-7592476|uniprotkb:Q3TH13|uniprotkb:Q78JW3|uniprotkb:Q8C4P1|intact:MINT-4125077|ensembl:ENSMUSP00000032477	intact:EBI-16078916|ensembl:ENSMUSP00000091151|ensembl:ENSMUSP00000117606|uniprotkb:D3Z3Q5	psi-mi:necp1_mouse(display_long)|uniprotkb:Necap1(gene name)|psi-mi:Necap1(display_short)|uniprotkb:NECAP endocytosis-associated protein 1(gene name synonym)	psi-mi:fcho1_mouse(display_long)|uniprotkb:Fcho1(gene name)|psi-mi:Fcho1(display_short)	psi-mi:"MI:0096"(pull down)	Ritter et al. (2013)	pubmed:24130457|doi:10.1371/journal.pbio.1001670|imex:IM-21954	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16079016|imex:IM-21954-8|dip:DIP-192594E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080543.2|ensembl:ENSMUSG00000030327(gene)|ensembl:ENSMUST00000032477(transcript)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030125"(clathrin vesicle coat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR012466(Adaptin ear-binding coat-associated protein 1 NECAP-1)|mint:Q9CR95|rcsb pdb:1TQZ|reactome:R-MMU-432722|reactome:R-MMU-8856825|reactome:R-MMU-8856828|dip:DIP-44062N	ensembl:ENSMUSG00000070000(gene)|ensembl:ENSMUST00000093444(transcript)|ensembl:ENSMUST00000146100(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030121|interpro:IPR031160|interpro:IPR042735|reactome:R-MMU-8856825|reactome:R-MMU-8856828|refseq:NP_082991.3|refseq:XP_006509828.1|refseq:XP_006509829.1|refseq:XP_006509830.1|dip:DIP-60611N	psi-mi:"MI:0465"(dip)	comment:mint|function:Involved in endocytosis	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:K6TGVkeAIMEFvb9sM1SS5bSdvjU10090	rogid:4m2nv9xHV8fOMoMKQh/lb4df4l410090	rigid:w9BDksdYKIkoulfF5lC5892qWBI	false	glutathione s tranferase tag:n-n|sufficient binding region:1-133|mutation decreasing interaction strength:95-95	mcherry fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)