#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P05024 uniprotkb:P05027 intact:EBI-9014019|uniprotkb:P18874 intact:EBI-9014008|ensembl:ENSSSCP00000006713|ensembl:ENSSSCP00025031098|ensembl:ENSSSCP00035036104|ensembl:ENSSSCP00045047697|ensembl:ENSSSCP00055016922|ensembl:ENSSSCP00070035369|ensembl:ENSSSCP00070035513|ensembl:ENSSSCP00070035557 psi-mi:at1a1_pig(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym) psi-mi:at1b1_pig(display_long)|uniprotkb:ATP1B1(gene name)|psi-mi:ATP1B1(display_short)|uniprotkb:Sodium/potassium-dependent ATPase subunit beta-1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Kanai et al. (2013) pubmed:24089211|doi:10.1038/nature12578|imex:IM-21942 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16077356|imex:IM-21942-1|dip:DIP-191509E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042470"(melanosome)|go:"GO:0051117"(ATPase binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:3B8E|rcsb pdb:3KDP|rcsb pdb:3N23|rcsb pdb:3WGU|go:"GO:0042383"(sarcolemma)|rcsb pdb:3WGV|rcsb pdb:4HYT|rcsb pdb:4RES|rcsb pdb:4RET|rcsb pdb:7D91|rcsb pdb:7D92|rcsb pdb:7D93|rcsb pdb:7D94|rcsb pdb:7DDF|rcsb pdb:7DDH|rcsb pdb:7DDI|rcsb pdb:7DDJ|rcsb pdb:7DDK|rcsb pdb:7DDL|rcsb pdb:7EVX|rcsb pdb:4HQJ|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0036376"(sodium ion export across plasma membrane)|refseq:NP_999414.1|dip:DIP-60365N ensembl:ENSSSCG00000006296(gene)|ensembl:ENSSSCG00025052482(gene)|ensembl:ENSSSCG00035064350(gene)|ensembl:ENSSSCG00045038671(gene)|ensembl:ENSSSCG00055010846(gene)|ensembl:ENSSSCG00070021088(gene)|ensembl:ENSSSCT00000006901(transcript)|ensembl:ENSSSCT00025071802(transcript)|ensembl:ENSSSCT00035086630(transcript)|refseq:XP_013852243.1|ensembl:ENSSSCT00045067159(transcript)|ensembl:ENSSSCT00055021364(transcript)|ensembl:ENSSSCT00070042092(transcript)|ensembl:ENSSSCT00070042253(transcript)|ensembl:ENSSSCT00070042300(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007155"(cell adhesion)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0051117"(ATPase binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:1903278"(positive regulation of sodium ion export across plasma membrane)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000402(ATPase, P-type cation exchange, beta subunit)|interpro:IPR015565(Sodium/Potassium-Dependent ATPase Beta-1 Subunit)|interpro:IPR038702|rcsb pdb:3B8E|rcsb pdb:3KDP|rcsb pdb:3N23|rcsb pdb:3WGU|rcsb pdb:3WGV|rcsb pdb:4HQJ|rcsb pdb:4HYT|rcsb pdb:4RES|rcsb pdb:4RET|rcsb pdb:7D91|rcsb pdb:7D92|rcsb pdb:7D93|rcsb pdb:7D94|rcsb pdb:7DDF|rcsb pdb:7DDH|rcsb pdb:7DDI|rcsb pdb:7DDJ|rcsb pdb:7DDK|rcsb pdb:7DDL|rcsb pdb:7EVX|refseq:NP_001001542.1|dip:DIP-60366N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") - 2017/08/07 2017/08/10 rogid:Q6TeLPrf7dQWeymBgfwFeiAJXjQ9823 rogid:RmJENGxmNigP0aQIKanuT/HSz8M9823 rigid:4YysPni1zkAgnoQqlUXbXxKBERg false sufficient binding region:20-1016 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P05024 uniprotkb:Q58K79 intact:EBI-9014019|uniprotkb:P18874 intact:EBI-9014004 psi-mi:at1a1_pig(display_long)|uniprotkb:ATP1A1(gene name)|psi-mi:ATP1A1(display_short)|uniprotkb:Sodium pump subunit alpha-1(gene name synonym) psi-mi:q58k79_pig(display_long)|uniprotkb:FXYD2(gene name)|psi-mi:FXYD2(display_short) psi-mi:"MI:0114"(x-ray crystallography) Kanai et al. (2013) pubmed:24089211|doi:10.1038/nature12578|imex:IM-21942 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16077356|imex:IM-21942-1|dip:DIP-191509E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0042470"(melanosome)|go:"GO:0051117"(ATPase binding)|go:"GO:0055085"(transmembrane transport)|go:"GO:0086009"(membrane repolarization)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:3B8E|rcsb pdb:3KDP|rcsb pdb:3N23|rcsb pdb:3WGU|go:"GO:0042383"(sarcolemma)|rcsb pdb:3WGV|rcsb pdb:4HYT|rcsb pdb:4RES|rcsb pdb:4RET|rcsb pdb:7D91|rcsb pdb:7D92|rcsb pdb:7D93|rcsb pdb:7D94|rcsb pdb:7DDF|rcsb pdb:7DDH|rcsb pdb:7DDI|rcsb pdb:7DDJ|rcsb pdb:7DDK|rcsb pdb:7DDL|rcsb pdb:7EVX|rcsb pdb:4HQJ|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030424"(axon)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031402"(sodium ion binding)|go:"GO:0036376"(sodium ion export across plasma membrane)|refseq:NP_999414.1|dip:DIP-60365N go:"GO:0001671"(ATPase activator activity)|go:"GO:0005890"("sodium:potassium-exchanging ATPase complex")|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0055085"(transmembrane transport)|go:"GO:0099106"(ion channel regulator activity)|go:"GO:1903408"("positive regulation of P-type sodium:potassium-exchanging transporter activity")|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR000272(Ion-transport regulator, FXYD region)|rcsb pdb:3B8E|rcsb pdb:3KDP|rcsb pdb:3N23|rcsb pdb:3WGU|rcsb pdb:3WGV|rcsb pdb:4HQJ|rcsb pdb:4HYT|rcsb pdb:4RES|rcsb pdb:4RET|rcsb pdb:7D91|rcsb pdb:7D92|rcsb pdb:7D93|rcsb pdb:7D94|rcsb pdb:7DDF|rcsb pdb:7DDG|rcsb pdb:7DDH|rcsb pdb:7DDI|rcsb pdb:7DDJ|rcsb pdb:7DDK|rcsb pdb:7DDL|go:"GO:0036376"(sodium ion export across plasma membrane)|refseq:NP_001014427.1|dip:DIP-60367N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") - 2017/08/07 2017/08/10 rogid:Q6TeLPrf7dQWeymBgfwFeiAJXjQ9823 rogid:K0HQ2MgTi9xA6ShQZW+rZ6gaY8k9823 rigid:4YysPni1zkAgnoQqlUXbXxKBERg false sufficient binding region:20-1016 sufficient binding region:15-49 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)