#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P68400 uniprotkb:P68400 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16073639|imex:IM-21569-1|dip:DIP-191989E - - psi-mi:"MI:0898"(putative self) psi-mi:"MI:0898"(putative self) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 rigid:SG6+a0YMgNFh661LIjoXiUmGqr4 false - - - 0 psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O61735 uniprotkb:P68400 intact:EBI-143834|uniprotkb:A4V1L9|uniprotkb:A4V1M0|uniprotkb:O76342|uniprotkb:O77137|uniprotkb:Q59E25|uniprotkb:Q9VSB0|ensemblmetazoa:FBpp0099478 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:clock_drome(display_long)|uniprotkb:Clk(gene name)|psi-mi:Clk(display_short)|uniprotkb:jrk(gene name synonym)|uniprotkb:CLOCK(gene name synonym)|uniprotkb:PAS1(gene name synonym)|uniprotkb:dCLOCK(gene name synonym)|uniprotkb:dPAS1(gene name synonym)|uniprotkb:CG7391(orf name) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16073677|imex:IM-21569-3|dip:DIP-191990E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0023076|refseq:NP_001014574.1|refseq:NP_001014576.1|refseq:NP_523964.2|dip:DIP-46595N|ensemblmetazoa:FBgn0023076(gene)|ensemblmetazoa:FBtr0100132(transcript)|reactome:R-DME-432524|reactome:R-DME-432560|reactome:R-DME-432620|reactome:R-DME-432626|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR035965|interpro:IPR036638|mint:O61735|reactome:R-DME-432395|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|reactome:R-DME-432408|reactome:R-DME-432501 rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:JUck6V2PVVXQJ0C6ro+ljBXge7E7227 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 rigid:10OEWYcCLHNr3guyBqijvR7UgIQ false - - - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:O61735 uniprotkb:P08181 intact:EBI-143834|uniprotkb:A4V1L9|uniprotkb:A4V1M0|uniprotkb:O76342|uniprotkb:O77137|uniprotkb:Q59E25|uniprotkb:Q9VSB0|ensemblmetazoa:FBpp0099478 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 psi-mi:clock_drome(display_long)|uniprotkb:Clk(gene name)|psi-mi:Clk(display_short)|uniprotkb:jrk(gene name synonym)|uniprotkb:CLOCK(gene name synonym)|uniprotkb:PAS1(gene name synonym)|uniprotkb:dCLOCK(gene name synonym)|uniprotkb:dPAS1(gene name synonym)|uniprotkb:CG7391(orf name) psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16073694|imex:IM-21569-4|dip:DIP-191988E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0023076|refseq:NP_001014574.1|refseq:NP_001014576.1|refseq:NP_523964.2|dip:DIP-46595N|ensemblmetazoa:FBgn0023076(gene)|ensemblmetazoa:FBtr0100132(transcript)|reactome:R-DME-432524|reactome:R-DME-432560|reactome:R-DME-432620|reactome:R-DME-432626|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR035965|interpro:IPR036638|mint:O61735|reactome:R-DME-432395|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|reactome:R-DME-432408|reactome:R-DME-432501 refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:JUck6V2PVVXQJ0C6ro+ljBXge7E7227 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rigid:ye+UNLTgFjzqIau2SAHCaUSMLS0 false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08181 uniprotkb:O61735 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 intact:EBI-143834|uniprotkb:A4V1L9|uniprotkb:A4V1M0|uniprotkb:O76342|uniprotkb:O77137|uniprotkb:Q59E25|uniprotkb:Q9VSB0|ensemblmetazoa:FBpp0099478 psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:clock_drome(display_long)|uniprotkb:Clk(gene name)|psi-mi:Clk(display_short)|uniprotkb:jrk(gene name synonym)|uniprotkb:CLOCK(gene name synonym)|uniprotkb:PAS1(gene name synonym)|uniprotkb:dCLOCK(gene name synonym)|uniprotkb:dPAS1(gene name synonym)|uniprotkb:CG7391(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073655|imex:IM-21569-2|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N flybase:FBgn0023076|refseq:NP_001014574.1|refseq:NP_001014576.1|refseq:NP_523964.2|dip:DIP-46595N|ensemblmetazoa:FBgn0023076(gene)|ensemblmetazoa:FBtr0100132(transcript)|reactome:R-DME-432524|reactome:R-DME-432560|reactome:R-DME-432620|reactome:R-DME-432626|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR035965|interpro:IPR036638|mint:O61735|reactome:R-DME-432395|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|reactome:R-DME-432408|reactome:R-DME-432501 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rogid:JUck6V2PVVXQJ0C6ro+ljBXge7E7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08181 uniprotkb:P49021 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 intact:EBI-266295|uniprotkb:O44380|uniprotkb:Q8I037|uniprotkb:Q95U67|uniprotkb:Q9VQR6|uniprotkb:Q9VQR7|intact:EBI-3407510|uniprotkb:M9MRE9|uniprotkb:A4V040|uniprotkb:B7Z007|uniprotkb:B7Z008|uniprotkb:C9QPB7|uniprotkb:Q1WWF5|uniprotkb:Q59E16|intact:EBI-9944820|ensemblmetazoa:FBpp0077256|ensemblmetazoa:FBpp0305454 psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:tim_drome(display_long)|uniprotkb:tim(gene name)|psi-mi:tim(display_short)|uniprotkb:CG3234(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073655|imex:IM-21569-2|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N refseq:NP_722914.3|flybase:FBgn0014396|refseq:NP_722912.3|refseq:NP_722913.3|refseq:NP_001014463.2|refseq:NP_001033872.2|refseq:NP_001137780.2|refseq:NP_001137781.2|refseq:NP_001188686.2|dip:DIP-29425N|ensemblmetazoa:FBgn0014396(gene)|ensemblmetazoa:FBtr0077567(transcript)|ensemblmetazoa:FBtr0333256(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007617"(mating behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009648"(photoperiodism)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0043111"(replication fork arrest)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0046957"(negative phototaxis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048478"(replication fork protection)|go:"GO:0048512"(circadian behavior)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rogid:wdN/j17nXo6XpfHUGGSo5zYNhog7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08181 uniprotkb:P07663 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 intact:EBI-496170|uniprotkb:O17483|uniprotkb:O76882|uniprotkb:O76883|uniprotkb:O76884|uniprotkb:O76885|uniprotkb:Q24446|uniprotkb:Q24447|uniprotkb:Q24448|uniprotkb:Q24449|uniprotkb:Q6PVA3|uniprotkb:Q8MLY0|uniprotkb:Q9GN20|uniprotkb:Q9GN51|uniprotkb:Q9GQH9|uniprotkb:Q9GV48|uniprotkb:Q9GV53|uniprotkb:Q9GV54|uniprotkb:Q9GV55|uniprotkb:Q9W4X0|ensemblmetazoa:FBpp0070455 psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:per_drome(display_long)|uniprotkb:Protein clock-6(gene name synonym)|uniprotkb:per(gene name)|psi-mi:per(display_short)|uniprotkb:CG2647(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073655|imex:IM-21569-2|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N refseq:NP_525056.2|flybase:FBgn0003068|refseq:NP_001259194.1|dip:DIP-29426N|ensemblmetazoa:FBgn0003068(gene)|ensemblmetazoa:FBtr0070477(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001306"(age-dependent response to oxidative stress)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007616"(long-term memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007619"(courtship behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0044297"(cell body)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045433"(male courtship behavior, veined wing generated song production)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0048512"(circadian behavior)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013767(PAS fold)|interpro:IPR035965|rcsb pdb:1WA9|rcsb pdb:3GEC|rcsb pdb:3RTY|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432524|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rogid:+l/mg+2MJForY5dORYWnWsVAhNI7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08181 uniprotkb:P08182 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 intact:EBI-128120|uniprotkb:Q76NS4|uniprotkb:Q9VYU4|ensemblmetazoa:FBpp0089135 psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:csk2b_drome(display_long)|uniprotkb:CkIIbeta(gene name)|psi-mi:CkIIbeta(display_short)|uniprotkb:Cask-II-b(gene name synonym)|uniprotkb:CG15224(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073655|imex:IM-21569-2|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N flybase:FBgn0000259|refseq:NP_001014731.1|refseq:NP_511131.3|refseq:NP_542940.1|refseq:NP_727561.1|refseq:NP_727562.1|refseq:NP_996415.1|refseq:NP_001245628.1|ensemblmetazoa:FBgn0000259(gene)|ensemblmetazoa:FBtr0073562(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016319"(mushroom body development)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0099523"(presynaptic cytosol)|reactome:R-DME-8934903|interpro:IPR000704(Casein kinase II, regulatory subunit)|reactome:R-DME-8948751|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6798695|reactome:R-DME-6804756|reactome:R-DME-6814122|dip:DIP-17048N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rogid:xiER9RXJ5YAbvII+LPCvwzp3s/47227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08182 uniprotkb:O61735 intact:EBI-128120|uniprotkb:Q76NS4|uniprotkb:Q9VYU4|ensemblmetazoa:FBpp0089135 intact:EBI-143834|uniprotkb:A4V1L9|uniprotkb:A4V1M0|uniprotkb:O76342|uniprotkb:O77137|uniprotkb:Q59E25|uniprotkb:Q9VSB0|ensemblmetazoa:FBpp0099478 psi-mi:csk2b_drome(display_long)|uniprotkb:CkIIbeta(gene name)|psi-mi:CkIIbeta(display_short)|uniprotkb:Cask-II-b(gene name synonym)|uniprotkb:CG15224(orf name) psi-mi:clock_drome(display_long)|uniprotkb:Clk(gene name)|psi-mi:Clk(display_short)|uniprotkb:jrk(gene name synonym)|uniprotkb:CLOCK(gene name synonym)|uniprotkb:PAS1(gene name synonym)|uniprotkb:dCLOCK(gene name synonym)|uniprotkb:dPAS1(gene name synonym)|uniprotkb:CG7391(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073713|imex:IM-21569-5|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000259|refseq:NP_001014731.1|refseq:NP_511131.3|refseq:NP_542940.1|refseq:NP_727561.1|refseq:NP_727562.1|refseq:NP_996415.1|refseq:NP_001245628.1|ensemblmetazoa:FBgn0000259(gene)|ensemblmetazoa:FBtr0073562(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016319"(mushroom body development)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0099523"(presynaptic cytosol)|reactome:R-DME-8934903|interpro:IPR000704(Casein kinase II, regulatory subunit)|reactome:R-DME-8948751|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6798695|reactome:R-DME-6804756|reactome:R-DME-6814122|dip:DIP-17048N flybase:FBgn0023076|refseq:NP_001014574.1|refseq:NP_001014576.1|refseq:NP_523964.2|dip:DIP-46595N|ensemblmetazoa:FBgn0023076(gene)|ensemblmetazoa:FBtr0100132(transcript)|reactome:R-DME-432524|reactome:R-DME-432560|reactome:R-DME-432620|reactome:R-DME-432626|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:1990513"(CLOCK-BMAL transcription complex)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR035965|interpro:IPR036638|mint:O61735|reactome:R-DME-432395|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|reactome:R-DME-432408|reactome:R-DME-432501 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:xiER9RXJ5YAbvII+LPCvwzp3s/47227 rogid:JUck6V2PVVXQJ0C6ro+ljBXge7E7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08182 uniprotkb:P49021 intact:EBI-128120|uniprotkb:Q76NS4|uniprotkb:Q9VYU4|ensemblmetazoa:FBpp0089135 intact:EBI-266295|uniprotkb:O44380|uniprotkb:Q8I037|uniprotkb:Q95U67|uniprotkb:Q9VQR6|uniprotkb:Q9VQR7|intact:EBI-3407510|uniprotkb:M9MRE9|uniprotkb:A4V040|uniprotkb:B7Z007|uniprotkb:B7Z008|uniprotkb:C9QPB7|uniprotkb:Q1WWF5|uniprotkb:Q59E16|intact:EBI-9944820|ensemblmetazoa:FBpp0077256|ensemblmetazoa:FBpp0305454 psi-mi:csk2b_drome(display_long)|uniprotkb:CkIIbeta(gene name)|psi-mi:CkIIbeta(display_short)|uniprotkb:Cask-II-b(gene name synonym)|uniprotkb:CG15224(orf name) psi-mi:tim_drome(display_long)|uniprotkb:tim(gene name)|psi-mi:tim(display_short)|uniprotkb:CG3234(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073713|imex:IM-21569-5|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000259|refseq:NP_001014731.1|refseq:NP_511131.3|refseq:NP_542940.1|refseq:NP_727561.1|refseq:NP_727562.1|refseq:NP_996415.1|refseq:NP_001245628.1|ensemblmetazoa:FBgn0000259(gene)|ensemblmetazoa:FBtr0073562(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016319"(mushroom body development)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0099523"(presynaptic cytosol)|reactome:R-DME-8934903|interpro:IPR000704(Casein kinase II, regulatory subunit)|reactome:R-DME-8948751|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6798695|reactome:R-DME-6804756|reactome:R-DME-6814122|dip:DIP-17048N refseq:NP_722914.3|flybase:FBgn0014396|refseq:NP_722912.3|refseq:NP_722913.3|refseq:NP_001014463.2|refseq:NP_001033872.2|refseq:NP_001137780.2|refseq:NP_001137781.2|refseq:NP_001188686.2|dip:DIP-29425N|ensemblmetazoa:FBgn0014396(gene)|ensemblmetazoa:FBtr0077567(transcript)|ensemblmetazoa:FBtr0333256(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007617"(mating behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009648"(photoperiodism)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0043111"(replication fork arrest)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0046957"(negative phototaxis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048478"(replication fork protection)|go:"GO:0048512"(circadian behavior)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:xiER9RXJ5YAbvII+LPCvwzp3s/47227 rogid:wdN/j17nXo6XpfHUGGSo5zYNhog7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08182 uniprotkb:P07663 intact:EBI-128120|uniprotkb:Q76NS4|uniprotkb:Q9VYU4|ensemblmetazoa:FBpp0089135 intact:EBI-496170|uniprotkb:O17483|uniprotkb:O76882|uniprotkb:O76883|uniprotkb:O76884|uniprotkb:O76885|uniprotkb:Q24446|uniprotkb:Q24447|uniprotkb:Q24448|uniprotkb:Q24449|uniprotkb:Q6PVA3|uniprotkb:Q8MLY0|uniprotkb:Q9GN20|uniprotkb:Q9GN51|uniprotkb:Q9GQH9|uniprotkb:Q9GV48|uniprotkb:Q9GV53|uniprotkb:Q9GV54|uniprotkb:Q9GV55|uniprotkb:Q9W4X0|ensemblmetazoa:FBpp0070455 psi-mi:csk2b_drome(display_long)|uniprotkb:CkIIbeta(gene name)|psi-mi:CkIIbeta(display_short)|uniprotkb:Cask-II-b(gene name synonym)|uniprotkb:CG15224(orf name) psi-mi:per_drome(display_long)|uniprotkb:Protein clock-6(gene name synonym)|uniprotkb:per(gene name)|psi-mi:per(display_short)|uniprotkb:CG2647(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073713|imex:IM-21569-5|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000259|refseq:NP_001014731.1|refseq:NP_511131.3|refseq:NP_542940.1|refseq:NP_727561.1|refseq:NP_727562.1|refseq:NP_996415.1|refseq:NP_001245628.1|ensemblmetazoa:FBgn0000259(gene)|ensemblmetazoa:FBtr0073562(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016319"(mushroom body development)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0099523"(presynaptic cytosol)|reactome:R-DME-8934903|interpro:IPR000704(Casein kinase II, regulatory subunit)|reactome:R-DME-8948751|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6798695|reactome:R-DME-6804756|reactome:R-DME-6814122|dip:DIP-17048N refseq:NP_525056.2|flybase:FBgn0003068|refseq:NP_001259194.1|dip:DIP-29426N|ensemblmetazoa:FBgn0003068(gene)|ensemblmetazoa:FBtr0070477(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001306"(age-dependent response to oxidative stress)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007616"(long-term memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007619"(courtship behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009266"(response to temperature stimulus)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0044297"(cell body)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045433"(male courtship behavior, veined wing generated song production)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0048512"(circadian behavior)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:1904059"(regulation of locomotor rhythm)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013767(PAS fold)|interpro:IPR035965|rcsb pdb:1WA9|rcsb pdb:3GEC|rcsb pdb:3RTY|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432524|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:xiER9RXJ5YAbvII+LPCvwzp3s/47227 rogid:+l/mg+2MJForY5dORYWnWsVAhNI7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08182 uniprotkb:P08181 intact:EBI-128120|uniprotkb:Q76NS4|uniprotkb:Q9VYU4|ensemblmetazoa:FBpp0089135 intact:EBI-93115|uniprotkb:Q0E8B4|uniprotkb:Q9W5T2|ensemblmetazoa:FBpp0070041|ensemblmetazoa:FBpp0070042|ensemblmetazoa:FBpp0070043|ensemblmetazoa:FBpp0110433|ensemblmetazoa:FBpp0311229|ensemblmetazoa:FBpp0311359|ensemblmetazoa:FBpp0311360 psi-mi:csk2b_drome(display_long)|uniprotkb:CkIIbeta(gene name)|psi-mi:CkIIbeta(display_short)|uniprotkb:Cask-II-b(gene name synonym)|uniprotkb:CG15224(orf name) psi-mi:csk2a_drome(display_long)|uniprotkb:CkIIalpha(gene name)|psi-mi:CkIIalpha(display_short)|uniprotkb:Cask-II-a(gene name synonym)|uniprotkb:CG17520(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Szabó et al. (2012) pubmed:24013921|doi:10.1371/journal.pbio.1001645|imex:IM-21569 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16073713|imex:IM-21569-5|dip:DIP-191987E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) flybase:FBgn0000259|refseq:NP_001014731.1|refseq:NP_511131.3|refseq:NP_542940.1|refseq:NP_727561.1|refseq:NP_727562.1|refseq:NP_996415.1|refseq:NP_001245628.1|ensemblmetazoa:FBgn0000259(gene)|ensemblmetazoa:FBtr0073562(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016319"(mushroom body development)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0099523"(presynaptic cytosol)|reactome:R-DME-8934903|interpro:IPR000704(Casein kinase II, regulatory subunit)|reactome:R-DME-8948751|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6798695|reactome:R-DME-6804756|reactome:R-DME-6814122|dip:DIP-17048N refseq:NP_001287151.1|refseq:NP_001287152.1|refseq:NP_001287153.1|refseq:NP_524918.1|refseq:NP_730774.1|refseq:NP_730775.1|ensemblmetazoa:FBgn0264492(gene)|ensemblmetazoa:FBtr0070042(transcript)|ensemblmetazoa:FBtr0070043(transcript)|ensemblmetazoa:FBtr0070044(transcript)|ensemblmetazoa:FBtr0111141(transcript)|ensemblmetazoa:FBtr0344974(transcript)|ensemblmetazoa:FBtr0345138(transcript)|ensemblmetazoa:FBtr0345139(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002118"(aggressive behavior)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007310"(oocyte dorsal/ventral axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0022416"(chaeta development)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048749"(compound eye development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060810"(intracellular mRNA localization involved in pattern specification process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-201688|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-2514853|reactome:R-DME-432553|reactome:R-DME-6804756|reactome:R-DME-6814122|reactome:R-DME-8934903|reactome:R-DME-8948751|refseq:NP_001036624.1|flybase:FBgn0264492|dip:DIP-18339N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/07 2017/08/10 rogid:xiER9RXJ5YAbvII+LPCvwzp3s/47227 rogid:0wrL1LjHFiPEQg3UxDl917ya/qg7227 rigid:0Emf3qsgYoCB0hKIZxneVL/jt7w false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)