#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21802-1	uniprotkb:P22607	intact:EBI-15489960|ensembl:ENSP00000351276	intact:EBI-348399|ensembl:ENSP00000414914|uniprotkb:Q14308|uniprotkb:Q16294|uniprotkb:Q16608|uniprotkb:D3DVP9|uniprotkb:D3DVQ0|uniprotkb:Q59FL9	psi-mi:p21802-1(display_long)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:FGFR2IIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)	psi-mi:fgfr3_human(display_long)|uniprotkb:FGFR3(gene name)|psi-mi:FGFR3(display_short)|uniprotkb:JTK4(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Huang et al. (2013)	pubmed:23972473|doi:10.1016/j.str.2013.07.017|imex:IM-21907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16071547|imex:IM-21907-1|dip:DIP-192478E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|intact:EBI-1028658(isoform-parent)	refseq:NP_000133.1|refseq:NP_001156685.1|refseq:NP_075254.1|ensembl:ENSG00000068078(gene)|ensembl:ENST00000440486(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030282"(bone mineralization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070977"(bone maturation)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|rcsb pdb:1RY7|rcsb pdb:2LZL|rcsb pdb:4K33|rcsb pdb:6LVM|rcsb pdb:6PNX|rcsb pdb:7DHL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839130|reactome:R-HSA-2033514|reactome:R-HSA-2033515|reactome:R-HSA-2219530|reactome:R-HSA-5654227|reactome:R-HSA-5654704|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654732|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|dip:DIP-4016N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rogid:5yOR7/EmXO7Wff9yKMSdZuWjIKU9606	rigid:aJSjsQHFbUASq22lGbG3fYAlZsM	false	sufficient binding region:761-821|phosphorylated residue:?-?	sufficient binding region:429-768	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22607	uniprotkb:P22607	intact:EBI-348399|ensembl:ENSP00000414914|uniprotkb:Q14308|uniprotkb:Q16294|uniprotkb:Q16608|uniprotkb:D3DVP9|uniprotkb:D3DVQ0|uniprotkb:Q59FL9	intact:EBI-348399|ensembl:ENSP00000414914|uniprotkb:Q14308|uniprotkb:Q16294|uniprotkb:Q16608|uniprotkb:D3DVP9|uniprotkb:D3DVQ0|uniprotkb:Q59FL9	psi-mi:fgfr3_human(display_long)|uniprotkb:FGFR3(gene name)|psi-mi:FGFR3(display_short)|uniprotkb:JTK4(gene name synonym)	psi-mi:fgfr3_human(display_long)|uniprotkb:FGFR3(gene name)|psi-mi:FGFR3(display_short)|uniprotkb:JTK4(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Huang et al. (2013)	pubmed:23972473|doi:10.1016/j.str.2013.07.017|imex:IM-21907	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16071571|imex:IM-21907-2|dip:DIP-192479E	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000133.1|refseq:NP_001156685.1|refseq:NP_075254.1|ensembl:ENSG00000068078(gene)|ensembl:ENST00000440486(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030282"(bone mineralization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070977"(bone maturation)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|rcsb pdb:1RY7|rcsb pdb:2LZL|rcsb pdb:4K33|rcsb pdb:6LVM|rcsb pdb:6PNX|rcsb pdb:7DHL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839130|reactome:R-HSA-2033514|reactome:R-HSA-2033515|reactome:R-HSA-2219530|reactome:R-HSA-5654227|reactome:R-HSA-5654704|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654732|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|dip:DIP-4016N	refseq:NP_000133.1|refseq:NP_001156685.1|refseq:NP_075254.1|ensembl:ENSG00000068078(gene)|ensembl:ENST00000440486(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030282"(bone mineralization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070977"(bone maturation)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|rcsb pdb:1RY7|rcsb pdb:2LZL|rcsb pdb:4K33|rcsb pdb:6LVM|rcsb pdb:6PNX|rcsb pdb:7DHL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839130|reactome:R-HSA-2033514|reactome:R-HSA-2033515|reactome:R-HSA-2219530|reactome:R-HSA-5654227|reactome:R-HSA-5654704|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654732|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|dip:DIP-4016N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:5yOR7/EmXO7Wff9yKMSdZuWjIKU9606	rogid:5yOR7/EmXO7Wff9yKMSdZuWjIKU9606	rigid:ITSPdbpV8uyYtGFQSdLGjWoUpEg	false	sufficient binding region:440-778|O4'-phospho-L-tyrosine:760-760,577-577|mutation decreasing interaction:761-761|mutation decreasing interaction strength:571-571	sufficient binding region:440-778|O4'-phospho-L-tyrosine:760-760,577-577|mutation decreasing interaction:761-761|mutation decreasing interaction strength:571-571	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)