#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IZD2-8	uniprotkb:O95944	intact:EBI-15014150	intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181	psi-mi:q8izd2-8(display_long)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 5(gene name synonym)|uniprotkb:KMT2E(gene name)|psi-mi:KMT2E(display_short)|uniprotkb:MLL5(gene name synonym)	psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym)	psi-mi:"MI:0727"(lexa b52 complementation)	Baychelier et al. (2013)	imex:IM-25776|pubmed:23958951	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15014145|imex:IM-25776-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2689959(isoform-parent)	refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127	-	-	-	figure legend:Supp Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/05/08	2017/06/08	rogid:CsxPwcgVY8tIdkdkxciajuYVSEc9606	rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606	rigid:5HBfbuKVTdmNizrrq9JxNr4mW2A	false	-	sufficient binding region:22..22-192..192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8IZD2-8	uniprotkb:O95944	intact:EBI-15014150	intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181	psi-mi:q8izd2-8(display_long)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 5(gene name synonym)|uniprotkb:KMT2E(gene name)|psi-mi:KMT2E(display_short)|uniprotkb:MLL5(gene name synonym)	psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Baychelier et al. (2013)	imex:IM-25776|pubmed:23958951	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15014167|imex:IM-25776-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2689959(isoform-parent)	refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127	-	-	-	figure legend:Fig 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-wm1361)|taxid:9606(human-wm1361 melanoma cell line)	-	2017/05/08	2017/05/31	rogid:CsxPwcgVY8tIdkdkxciajuYVSEc9606	rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606	rigid:5HBfbuKVTdmNizrrq9JxNr4mW2A	false	-	sufficient binding region:22-190|fc-igg tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IZD2-8	uniprotkb:O95944	intact:EBI-15014150	intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181	psi-mi:q8izd2-8(display_long)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 5(gene name synonym)|uniprotkb:KMT2E(gene name)|psi-mi:KMT2E(display_short)|uniprotkb:MLL5(gene name synonym)	psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Baychelier et al. (2013)	imex:IM-25776|pubmed:23958951	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15037724|imex:IM-25776-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2689959(isoform-parent)	refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127	-	-	-	figure legend:Fig 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/08	2017/05/31	rogid:CsxPwcgVY8tIdkdkxciajuYVSEc9606	rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606	rigid:5HBfbuKVTdmNizrrq9JxNr4mW2A	false	-	sufficient binding region:22-190|fc-igg tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q8IZD2	uniprotkb:O95944	intact:EBI-2689959|uniprotkb:Q86TI3|uniprotkb:B6ZDM3|uniprotkb:Q8IWR5|uniprotkb:B6ZDE4|uniprotkb:Q6P5Y2|uniprotkb:Q86WG0|uniprotkb:Q86W12|uniprotkb:Q8NFF8|uniprotkb:Q8IV78|uniprotkb:Q86WL2|uniprotkb:Q6T316|uniprotkb:Q9NWE7|uniprotkb:Q6PKG4|intact:EBI-2815322|uniprotkb:M4K8J3|intact:EBI-28975207|ensembl:ENSP00000257745|ensembl:ENSP00000312379	intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181	psi-mi:kmt2e_human(display_long)|uniprotkb:KMT2E(gene name)|psi-mi:KMT2E(display_short)|uniprotkb:MLL5(gene name synonym)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 5(gene name synonym)	psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Baychelier et al. (2013)	imex:IM-25776|pubmed:23958951	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096590|imex:IM-25776-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000312379|ensembl:ENST00000334884|ensembl:ENSP00000335398|ensembl:ENST00000476671|ensembl:ENSP00000417888|ensembl:ENSP00000257745|refseq:XP_011514702.1|refseq:NP_061152.3|refseq:NP_891847.1|refseq:XP_005250550.1|ensembl:ENSG00000005483(gene)|ensembl:ENST00000257745(transcript)|ensembl:ENST00000311117(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0006306"(DNA methylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035327"|go:"GO:0042119"(neutrophil activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1905437"(positive regulation of histone H3-K4 trimethylation)|interpro:IPR001214(SET)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR037955|interpro:IPR044434|rcsb pdb:2LV9|rcsb pdb:4L58|rcsb pdb:5HT6|reactome:R-HSA-3214841|reactome:R-HSA-8936459	refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127	-	-	-	figure legend:Fig 2D|comment:The antibody to MLL5 used was targetted  to the N-terminal domain, common to all MLL5 isoforms.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/08	2017/06/01	rogid:R88sB8694YH12wYZLv4PLcpqegU9606	rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606	rigid:wvmjzjSEgM+A+D+SRSq6W0MM+bY	false	-	sufficient binding region:22-190|fc-igg tag:c-c	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:O95944	uniprotkb:Q8IZD2-8	intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181	intact:EBI-15014150	psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym)	psi-mi:q8izd2-8(display_long)|uniprotkb:Myeloid/lymphoid or mixed-lineage leukemia protein 5(gene name synonym)|uniprotkb:KMT2E(gene name)|psi-mi:KMT2E(display_short)|uniprotkb:MLL5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Baychelier et al. (2013)	imex:IM-25776|pubmed:23958951	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15096609|imex:IM-25776-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127	intact:EBI-2689959(isoform-parent)	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig 4B, Supp 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2017/05/08	2017/06/01	rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606	rogid:CsxPwcgVY8tIdkdkxciajuYVSEc9606	rigid:5HBfbuKVTdmNizrrq9JxNr4mW2A	false	sufficient binding region:22-190|fc-igg tag:c-c	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)