#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15628	uniprotkb:B7UI21	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-16070376|ensemblbacteria:CAS10779	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:nleb1_eco27(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:nleB(gene name synonym)|uniprotkb:E2348C_3231(locus name)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070384|imex:IM-21832-2|dip:DIP-192228E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	ensemblbacteria:CAS10779(transcript)|ensemblbacteria:E2348C_3231(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034054"(suppression by symbiont of host defense-related programmed cell death)|go:"GO:0085034"(suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)|rcsb pdb:6ACI|rcsb pdb:6E66|refseq:WP_012578998.1|dip:DIP-60511N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:xbfOIuSfSXVHLS0Pvfcy1zeoxA8574521	rigid:h8gI1MgXbpl6MJuwFXU28N1njI4	false	sufficient binding region:195-312	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12933	uniprotkb:Q15628	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070357|imex:IM-21832-1|dip:DIP-44961E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:KaakIa6PJLwcwzH3ZPICUpQx+sg	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:P19438	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q96EP0	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-948111|uniprotkb:Q9H5F1|uniprotkb:Q9NWD2|uniprotkb:Q86VI2|uniprotkb:Q8TEI0|uniprotkb:Q96GB4|uniprotkb:Q96NF1|ensembl:ENSP00000315112|ensembl:ENSP00000496609|uniprotkb:A0A962	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:rnf31_human(display_long)|uniprotkb:Zinc in-between-RING-finger ubiquitin-associated domain protein(gene name synonym)|uniprotkb:RNF31(gene name)|psi-mi:RNF31(display_short)|uniprotkb:ZIBRA(gene name synonym)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	ensembl:ENSG00000092098(gene)|ensembl:ENSG00000285152(gene)|ensembl:ENST00000324103(transcript)|ensembl:ENST00000647495(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|refseq:NP_060469.4|refseq:NP_001297261.1|ensembl:ENSP00000315112|ensembl:ENST00000559275|ensembl:ENSP00000453574|ensembl:ENST00000642631|ensembl:ENSP00000494011|ensembl:ENSP00000496609|dip:DIP-44034N|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066|mint:Q96EP0|rcsb pdb:2CT7|rcsb pdb:4DBG|rcsb pdb:4JUY|rcsb pdb:4LJO|rcsb pdb:4LJP|rcsb pdb:4LJQ|rcsb pdb:4OWF|rcsb pdb:4OYJ|rcsb pdb:4OYK|rcsb pdb:4P09|rcsb pdb:4P0A|rcsb pdb:4P0B|rcsb pdb:5EDV|rcsb pdb:5X0W|rcsb pdb:6GZY|rcsb pdb:6KC5|rcsb pdb:6KC6|rcsb pdb:6SC5|rcsb pdb:6SC6|rcsb pdb:6SC7|rcsb pdb:6SC8|rcsb pdb:6SC9|reactome:R-HSA-5357905|reactome:R-HSA-5357956|rcsb pdb:5LJN	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:5QylozByg2G8/5LnkorkdY5fPec9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q9H0F6	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-3942966|uniprotkb:D3DWL3|uniprotkb:Q8IXF5|uniprotkb:Q8IXF6|uniprotkb:A6NEG3|uniprotkb:Q8TB25|uniprotkb:Q9BUE4|uniprotkb:Q8N2E7|uniprotkb:C0L3L2|ensembl:ENSP00000381698	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:shrpn_human(display_long)|uniprotkb:SHARPIN(gene name)|psi-mi:SHARPIN(display_short)|uniprotkb:SIPL1(gene name synonym)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:PSEC0216(orf name)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	ensembl:ENSG00000179526(gene)|ensembl:ENST00000398712(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|reactome:R-HSA-6794361|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|mint:Q9H0F6|rcsb pdb:4EMO|rcsb pdb:5X0W|reactome:R-HSA-5357905|reactome:R-HSA-5357956|refseq:NP_112236.3|refseq:XP_016869377.1|dip:DIP-57842N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:+RGl3JO1zsGCdaInDn20yhNZs0E9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q9BYM8	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q13546	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q12933	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q15628	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070403|imex:IM-21832-3|dip:DIP-192229E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:8uAjZ+PmnKM4T2ngIN613lmximc	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:Q13158	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070428|imex:IM-21832-4|dip:DIP-188716E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	rigid:p+gIZHsIPmj1wQvWPZPzvAVZntc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14790	uniprotkb:Q13546	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070428|imex:IM-21832-4|dip:DIP-188716E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rigid:p+gIZHsIPmj1wQvWPZPzvAVZntc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15628	uniprotkb:B7UI21	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-16070376|ensemblbacteria:CAS10779	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:nleb1_eco27(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:nleB(gene name synonym)|uniprotkb:E2348C_3231(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070446|imex:IM-21832-5|dip:DIP-192228E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	ensemblbacteria:CAS10779(transcript)|ensemblbacteria:E2348C_3231(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034054"(suppression by symbiont of host defense-related programmed cell death)|go:"GO:0085034"(suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)|rcsb pdb:6ACI|rcsb pdb:6E66|refseq:WP_012578998.1|dip:DIP-60511N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:xbfOIuSfSXVHLS0Pvfcy1zeoxA8574521	rigid:h8gI1MgXbpl6MJuwFXU28N1njI4	false	flag tag:n-n|ha tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13158	uniprotkb:Q15628	intact:EBI-494804|uniprotkb:Q14866|uniprotkb:Q6IBR4|ensembl:ENSP00000301838	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:fadd_human(display_long)|uniprotkb:FAS-associating death domain-containing protein(gene name synonym)|uniprotkb:Mediator of receptor induced toxicity(gene name synonym)|uniprotkb:FADD(gene name)|psi-mi:FADD(display_short)|uniprotkb:MORT1(gene name synonym)|uniprotkb:GIG3(orf name)|uniprotkb:Growth-inhibiting gene 3 protein(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070470|imex:IM-21832-6|dip:DIP-302E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003815.1|dip:DIP-286N|ensembl:ENSG00000168040(gene)|ensembl:ENST00000301838(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002020"(protease binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070236"(negative regulation of activation-induced cell death of T cells)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0089720"(caspase binding)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097342"(ripoptosome)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2000454"(positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR016729(FADD)|mint:Q13158|rcsb pdb:1A1W|rcsb pdb:1A1Z|rcsb pdb:1E3Y|rcsb pdb:1E41|rcsb pdb:2GF5|rcsb pdb:3EZQ|rcsb pdb:3OQ9|rcsb pdb:6ACI|reactome:R-HSA-140534|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9693928	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:DzaWyJjHDsNt8nMWLbv6GYa0Ri49606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:9X2bEkYKbJtIz4suWYI2vAsYZyw	false	ha tag:n-n	flag tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P01375	uniprotkb:P19438	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070494|imex:IM-21832-7|dip:DIP-192230E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rigid:0eiDg+fe7puzksVSd0HvfW6gYgM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q12933	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070494|imex:IM-21832-7|dip:DIP-192230E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rigid:0eiDg+fe7puzksVSd0HvfW6gYgM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01375	uniprotkb:Q15628	intact:EBI-359977|uniprotkb:O43647|uniprotkb:Q9P1Q2|uniprotkb:Q9UIV3|ensembl:ENSP00000365290|ensembl:ENSP00000372988|ensembl:ENSP00000389490|ensembl:ENSP00000389492|ensembl:ENSP00000392858|ensembl:ENSP00000398698|ensembl:ENSP00000410668	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnfa_human(display_long)|uniprotkb:TNF(gene name)|psi-mi:TNF(display_short)|uniprotkb:TNFA(gene name synonym)|uniprotkb:TNFSF2(gene name synonym)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070494|imex:IM-21832-7|dip:DIP-192230E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204490(gene)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0002020"(protease binding)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009615"(response to virus)|go:"GO:0009651"(response to salt stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|ensembl:ENSG00000206439(gene)|ensembl:ENSG00000223952(gene)|ensembl:ENSG00000228321(gene)|ensembl:ENSG00000228849(gene)|ensembl:ENSG00000230108(gene)|ensembl:ENSG00000232810(gene)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|ensembl:ENST00000376122(transcript)|ensembl:ENST00000383496(transcript)|ensembl:ENST00000412275(transcript)|ensembl:ENST00000420425(transcript)|ensembl:ENST00000443707(transcript)|ensembl:ENST00000448781(transcript)|ensembl:ENST00000449264(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-HSA-75893|reactome:R-HSA-6785807|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|mint:P01375|rcsb pdb:1A8M|rcsb pdb:1TNF|rcsb pdb:2AZ5|rcsb pdb:2E7A|rcsb pdb:2TUN|rcsb pdb:2ZJC|rcsb pdb:2ZPX|rcsb pdb:3ALQ|rcsb pdb:3IT8|rcsb pdb:3L9J|rcsb pdb:3WD5|rcsb pdb:4G3Y|rcsb pdb:4TSV|rcsb pdb:4TWT|rcsb pdb:4Y6O|rcsb pdb:5M2I|rcsb pdb:5M2J|rcsb pdb:5M2M|rcsb pdb:5MU8|rcsb pdb:5TSW|rcsb pdb:5WUX|rcsb pdb:5YOY|rcsb pdb:6OOY|rcsb pdb:6OOZ|rcsb pdb:6OP0|rcsb pdb:6RMJ|rcsb pdb:6X81|rcsb pdb:6X82|rcsb pdb:6X83|rcsb pdb:6X85|rcsb pdb:6X86|rcsb pdb:7ASY|rcsb pdb:7AT7|rcsb pdb:7ATB|rcsb pdb:7JRA|rcsb pdb:7KP9|rcsb pdb:7KPA|rcsb pdb:7KPB|reactome:R-HSA-381340|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:5UUI|reactome:R-HSA-5668541|reactome:R-HSA-6783783|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071230"(cellular response to amino acid stimulus)|refseq:NP_000585.2|dip:DIP-2895N	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:27bbNim4bHFyBJscZC+/v9o96+g9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:0eiDg+fe7puzksVSd0HvfW6gYgM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15628	uniprotkb:B7UI21	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-16070376|ensemblbacteria:CAS10779	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:nleb1_eco27(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:nleB(gene name synonym)|uniprotkb:E2348C_3231(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070562|imex:IM-21832-10|dip:DIP-192228E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	ensemblbacteria:CAS10779(transcript)|ensemblbacteria:E2348C_3231(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034054"(suppression by symbiont of host defense-related programmed cell death)|go:"GO:0085034"(suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)|rcsb pdb:6ACI|rcsb pdb:6E66|refseq:WP_012578998.1|dip:DIP-60511N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:xbfOIuSfSXVHLS0Pvfcy1zeoxA8574521	rigid:h8gI1MgXbpl6MJuwFXU28N1njI4	false	-	flag tag:n-n|mutation disrupting interaction strength:223-223,221-221	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15628	uniprotkb:Q12933	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070540|imex:IM-21832-9|dip:DIP-192231E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rigid:q1D6U2jwpjhp0lcY4WCR5QvO62I	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15628	uniprotkb:B7UI21	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-16070376|ensemblbacteria:CAS10779	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:nleb1_eco27(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:nleB(gene name synonym)|uniprotkb:E2348C_3231(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070540|imex:IM-21832-9|dip:DIP-192231E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	ensemblbacteria:CAS10779(transcript)|ensemblbacteria:E2348C_3231(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034054"(suppression by symbiont of host defense-related programmed cell death)|go:"GO:0085034"(suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)|rcsb pdb:6ACI|rcsb pdb:6E66|refseq:WP_012578998.1|dip:DIP-60511N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:xbfOIuSfSXVHLS0Pvfcy1zeoxA8574521	rigid:q1D6U2jwpjhp0lcY4WCR5QvO62I	false	flag tag:n-n	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15628	uniprotkb:B7UI21	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	intact:EBI-16070376|ensemblbacteria:CAS10779	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:nleb1_eco27(display_long)|uniprotkb:nleB1(gene name)|psi-mi:nleB1(display_short)|uniprotkb:Non-LEE-encoded type III effector B1(gene name synonym)|uniprotkb:nleB(gene name synonym)|uniprotkb:E2348C_3231(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:574521(eco27)|taxid:574521("Escherichia coli O127:H6 (strain E2348/69 / EPEC)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070515|imex:IM-21832-8|dip:DIP-192228E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	ensemblbacteria:CAS10779(transcript)|ensemblbacteria:E2348C_3231(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034054"(suppression by symbiont of host defense-related programmed cell death)|go:"GO:0085034"(suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:0090729"(toxin activity)|go:"GO:0106362"(protein-arginine N-acetylglucosaminyltransferase activity)|rcsb pdb:6ACI|rcsb pdb:6E66|refseq:WP_012578998.1|dip:DIP-60511N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rogid:xbfOIuSfSXVHLS0Pvfcy1zeoxA8574521	rigid:h8gI1MgXbpl6MJuwFXU28N1njI4	false	sufficient binding region:195-312|flag tag:n-n|necessary binding region:195-312	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P19438	uniprotkb:Q15628	intact:EBI-299451|ensembl:ENSP00000162749|uniprotkb:A8K4X3|uniprotkb:B2RDE4|uniprotkb:B3KPQ1|uniprotkb:B4DQB7|uniprotkb:B4E309|uniprotkb:Q9UCA4|uniprotkb:D3DUR1|uniprotkb:B5M0B5	intact:EBI-359215|uniprotkb:Q52NZ1|uniprotkb:B2RDS3|uniprotkb:B3KQZ9|ensembl:ENSP00000341268	psi-mi:tnr1a_human(display_long)|uniprotkb:TNFRSF1A(gene name)|psi-mi:TNFRSF1A(display_short)|uniprotkb:TNFAR(gene name synonym)|uniprotkb:TNFR1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:tradd_human(display_long)|uniprotkb:TRADD(gene name)|psi-mi:TRADD(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2013)	pubmed:23955153|doi:10.1038/nature12436|imex:IM-21832	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070585|imex:IM-21832-11|dip:DIP-78E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000067182(gene)|ensembl:ENST00000162749(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P19438|rcsb pdb:1EXT|rcsb pdb:1FT4|rcsb pdb:1ICH|rcsb pdb:1NCF|rcsb pdb:1TNR|rcsb pdb:7K7A|rcsb pdb:7KP7|rcsb pdb:7KP8|rcsb pdb:7KPB|go:"GO:1903140"(regulation of establishment of endothelial barrier)|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|reactome:R-HSA-5669034|reactome:R-HSA-6783783|reactome:R-HSA-75893|refseq:NP_001056.1|dip:DIP-407N|refseq:NP_001333020.1|refseq:NP_001333021.1	refseq:NP_003780.1|refseq:XP_005256270.1|refseq:NP_001310481.1|refseq:XP_016879304.1|dip:DIP-285N|ensembl:ENSG00000102871(gene)|ensembl:ENST00000345057(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|mint:Q15628|rcsb pdb:1F2H|rcsb pdb:1F3V|rcsb pdb:5XME|rcsb pdb:6AC0|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9693928	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:A9Ga60ipENjSsgt59TfNchYqXtw9606	rogid:waTMnn0uXSbf7bracJUScX9ckEc9606	rigid:FObu64Od4q9pD1jAVDz5znyJdEU	false	sufficient binding region:350-445|ha tag:n-n	flag tag:n-n|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)